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Grow Your Brain at Any Age
Majid Fotuhi, MD PhD
Howard County Office on AgingColumbia, MDMarch 28, 2014
New Discoveries
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“This book may be the most important you’ll ever read. Certainly, what Dr. Fotuhi teaches in this book has
changed my life.”
Michael Roizen, M.D. Chairman of the Wellness Institute- The Cleveland Clinic
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“Dr. Fotuhi has summarized the latest discoveries that show how we can grow our
brains bigger and stronger…”
Mehmet Oz, M.D.
The Dr. Oz Show
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Objectives What happens to our brain
with aging? How to reverse age-related
brain atrophy? Brain Fitness Program
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Memory Lapses
Memory lapses or Alzheimer’s?
Age-Associated Memory
Impairment MCI
Alzheimer’s
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Short-term: HippocampusLong-term: Cortex
Cortex Hippocampus
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Hippocampus
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Beautiful Neurons in Hippocampus
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With Aging, Hippocampus Atrophies Faster
than the Rest of the Brain
Hippocampus shrinks by about 0.5% per year after age 50
That is the reason memory lapses become more frequent after age 50
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Overlapping Causes of Atrophy in Hippocampus
Obesity Stroke
Sleep Apnea
Concussion AD
Diabetes
Hypertension
Stress
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Higher Risk of AD for Those with Midlife Hypertension plus High
Cholesterol Longitudinal Study
(1972, 1977, 1982, 1998) 1449 participants 57 cases of dementia,
48 with AD Mild hypertension:
<140 Severe hypertension:
>160 High cholesterol:
>250
00.5
11.5
22.5
33.5
MildHTN
SevereHTN
HighChol
HTNplusHighCholBMJ 2001; 322:1447–51
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Less Brain Volume in Patients with Sleep Apnea
Am J Respir Crit Care Med 2002; 166:1382–7
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Vascular Risk Factors Shrink the Brain, Especially the Hippocampus
Multiple Vascular
Risk Factors
No Vascular
Risk Factors
HippocampusHippocampus
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Obesity Shrinks the Brain
Associated with reduced brain volume
Ward, et al., 2005
Slows cognitive function
Debette, et al., 2011
Brains of overweight and obese individuals appeared 8 and 16 years older, respectively
Raji, et al., 2010
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Brain Research Volume 1280, 14 July 2009, Pages 186–194
Stress Shrinks Brain Cells in Hippocampus
StressControl
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Alzheimer’s: Plaques and Tangles
Plaques: gum-like collection of a protein called Amyloid
Tangles: abnormal aggregation of a protein called Tau
Inflammation
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Why do we forget names?
Hypertension Diabetes Alcoholism Depression Heart failure Obesity High cholesterol Head trauma Aging
Poor sleep Too much work Information overload Too many
responsibilities Fatigue Poor attention Poor diet “Can’t do it”
mentality
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DiabetesHypertensionObesitySleep ApneaHead TraumaGenesStress
Brain-healthy DietPhysical FitnessCognitive StimulationMeditation
Objectives What happens to our brain
with aging? How to reverse age-related
brain atrophy? Brain Fitness Program
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6 Steps to Grow Your Brain
1. Get Fit
2. Tease Your Memory
3. Eat Well &Take DHA
4. Sleep
5. Relax Your Mind
6. Start Early
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1. Hippocampus Grows Biggerwith Getting Fit
Erikson, PNAS 2011
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Brain is a Highly Vascular Organ
Zlokovic et al. Neurosurgery 43(4), 877–78, 1998
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Arch Gen Psychiatry, 2010
Hippocampus Grows Biggerwith Exercise, Even After 3
Months
After
Before
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Draganski et al. J Neurosci 2006; 26:6314–7
2. Hippocampus Grows Bigger with Memorization Training
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3. Hippocampus Grows Bigger with
Eating Well & Taking DHA
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4. Hippocampus Grows Bigger with Treatment of Sleep Apnea
Canesa, American Journal of Respiratory Medicine, 2011
5. Hippocampus Grows Bigger with Relaxing Your Mind
Holzel , Psychiatric Research, 2011
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6. Hippocampus Grows BiggerWhen You Start Early
Objectives What happens to our brain
with aging? How to reverse age-related
brain atrophy? Brain Fitness Program
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Brain Fitness Program
A multidisciplinary program devoted to: • Improving memory and brain performance
• Enhancing long-term brain health
• Reducing risk for dementia, Alzheimer’s disease and stroke in the future
Each patient receives a comprehensive baseline assessment followed by a personalized treatment plan
This program is based on latest research and has shown remarkable results
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Comprehensive Diagnostics to Evaluate Brain
Health
Customized Treatment Program to Maximize Brain
Performance
NeurExpand’s Unique Integrative Approach
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Remarkable Results
Hippocampus
HC
After
Before
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DiabetesHypertensionObesitySleep ApneaHead TraumaGenesStress
Brain-healthy DietPhysical FitnessCognitive StimulationMeditation
