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glucoseG6P
G1P
Glycogen
UDP-Glucose
GlycolysisGluconeogenesis
Pyruvate
Lactic acid
Alanine
Ribose-6-P
Pentose phosphatepathway
Uric acid
GBE1
GYS1, 2
G6PC2, 3
GK
PGM1
PYGMUGP2
PHKA2 PKABeta adrenergic Receptors
GCKR
Acetyl CoAACLY
GSK3B
AKT1, 2 INSRIRSPI3K
TCA cycle citrateFatty acid oxidation
respiratory chain
UCP1, 2, 3
Heat
ATP synthases
ATP
H+H+ H+
mitochondria
Glycolysis and Gluconeogenesis in Liver
PKLR
G6PDPGD
OAA
malateME1
SLC2A2(GLUT2)glucose
F6P
F1,6,P
FBP1, 2 PFKL
SREBF112061893 PRKCD
AMPK
LEPR
ADIPOR1, 2
CAMKK1, 2
Ca++
PKA cAMP
PPARGC1A CRTC2
FBXW7
TSC1TSC2
RHEB
MTORC1
PDK1
RPS6KB1EIF4EBP1
LPIN1, 2
NR1H3(LXR)
FOXO1
MLXIPL(CHREBP) MLXIPL(CHREBP)
PPTPA(PPP2R4)PPP2R1A
PPP2CA, B
PKA
PP2A
EP300CREBBPOGT
MLX
phosphoenolpyruvic acid, PEP
PEP
PCK1
NR1H4(FXR)
Bile acid
oxysterols
AGL
ENO1,2,3,4
G6PCLifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
AMPK
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
PI3K
PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R4PIK3R5PIK3R6
PKA
PRKACAPRKACBPRKACGPRKAR1APRKAR1BPRKAR2APRKAR2B
β ARsADRB1ADRB2ADRB3
PP2A PP2Aalpha subunit PPP2CAPP2Abeta subunitPPP2CBPP2Agamma subunit
(Protein phosphatase 2A)
PPP2R1APPP2R1BPPP2R2APPP2R2BPPP2R2CPPP2R2DPPP2R3APPP2R3BPPP2R4PPP2R5APPP2R5BPPP2R5CPPP2R5DPPP2R5ESTRN(PPP2R6A)
STRN3(PPP2R6B)STRN4(PPP2R6C)
Strm(Strn2)
PP2Agamma subunit
IRS
IRS1
IRS2
Irs3
IRS4
MTORC1
AKT1S1(PRAS40)DEPTORRPTOR(RAPTOR)MLST8(mLST8/GβL)MTOR
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
Pyruvate Lactic acidAlanine
SREBF1 PRKCD
Acetyl CoA
FA
Malonyl CoA
Fatty acyl-CoA
Triglycerides(TG)
ACACAACLY
FASN
GPAM
DGATs
PNPLA2(ATGL)LIPE(HSL)
LIPE(HSL)
FA DG
MGFA
MGLLFA
glycerol
AKT1, 2 INSRIRSPI3K
SCD
TCA cycle
citrate
Fatty acid β-oxidation
respiratory chain
UCP1, 2, 3
Heat
ATP synthases
ATP
H+H+ H+
mitochondria
PKLR
OAAmalate
ME1
12061893
F6P
F1,6,P
AMPK
LEPR
ADIPOR1, 2
CAMKK1, 2
Ca++PKA cAMP
PCK2(PEPCK)
PPARGC1ACRTC2
mTORC1
VLDLLPL
IDL LDLtransport
3-Hydroxybutyric acid
BDH1, 2 acetone
HMGCS2
AcAcCoA
HMGCoA
HMGCL
acetoacetate
ACAT1
VLDLR
HMGCR
Lipid metabolism in Liver
MLXIPL(CHREBP) MLXIPL(CHREBP)
PPTPAPPP2R1A
PPP2CA, B
PKA
PP2A
EP300CREBBPOGT
MLX
ACOT1
PDK1
NR0B2(SHP)NR1H4(FXR)
Bile acid
NR1H3(LXR)
oxysterols
Enoyl-CoA
LTB4
HETEs
16:0/18:1-GCP
CPT1A
peroxisome
Fatty acid β-oxidation
ACOX1, 2, 3
THRA, B
PPARD
Artherogenicdyslipidaemia
VLDL-TG↓
LDL↓
HDL-choresterol↑
FA-oxidation↑APOA1, 2
PPARARXRA
MED1
29558390
oxidative stress
FGF21 NFE2L2EIF2AK1
ANGPTL4
ALDH3A2CPT2
19805517
20378851
LPIN2ST3GAL5
29289645ATF4
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
AMPK
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
PI3K
PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R4PIK3R5PIK3R6
PKA
PRKACAPRKACBPRKACGPRKAR1APRKAR1BPRKAR2APRKAR2B
PP2A PP2Aalpha subunit PPP2CAPP2Abeta subunitPPP2CBPP2Agamma subunit
(Protein phosphatase 2A)
PPP2R1APPP2R1BPPP2R2APPP2R2BPPP2R2CPPP2R2DPPP2R3APPP2R3BPPP2R4PPP2R5APPP2R5BPPP2R5CPPP2R5DPPP2R5ESTRN(PPP2R6A)
STRN3(PPP2R6B)STRN4(PPP2R6C)
Strm(Strn2)
PP2Agamma subunit
IRS
IRS1
IRS2
Irs3
IRS4
MTORC1
AKT1S1(PRAS40)DEPTORRPTOR(RAPTOR)MLST8(mLST8/GβL)MTOR
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
Cholesterol / Bile Acid Synthesis and Secretion in Liver
SLC4A2
Bile Duct
Canalicular
ABCG5
ABCG8Cholesterol
ABCB4(MDR2, 3)Phospholipids
ABCB11(BSEP)
ABCC2(MRP2)Bile acid
Bile
SLC10A1(NTCP)
SLCO1B1(OATP2)
Na+
MDM4(MRP1)
ABCC3(MRP3)
ABCC4(MRP4)
SLC51A(OSTA)
SLC51B(OSTB)
Glycocholic acid
Taurocholic acid
Bile acid Bile acid Bile acid
NR0B2(SHP)
NR1I2(PXR)
PPARA
Cholesterol
Cholyl-CoA
CYP7A1
CYP8B1
NR1H4(FXR)
NR1I3
NR3C1(GR)
SLC4A2(AE2)
Acetyl CoA
AcAcCoA
HMGCoA
mevalonic acidHMGCR
ACAT1
HMGCS2
MVK
7α-Hydroxycholesterol
Bile acid
NR1H3(LXR) oxysterols
HNF4A
NR5A2(LRH1)
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
SLC10A1(NTCP)
ABCG5
ABCB11(BSEP)
NR0B2(SHP)
NR1I2(PXR)
NR1I3
PPARA
Cholesterol
7α-Hydroxycholesterol
Cholyl-CoA
CYP7A1
CYP8B1
Na+
Cholesterol
Phospholipids
NR3C1(GR)
Canalicular
Cl-
HCO3-
Bile acid
Bile acid
Bile DuctBile
Bile acid
Regulation of Bile acid synthesis and transportIn Liver
NR1H4(FXR)
MDM4(MRP1)
ABCC3(MRP3)
ABCC4(MRP4)
ABCG8
ABCB4(MDR2, 3)
ABCC2(MRP2)
SLC4A2(AE2)
Taurocholic acid
Glycocholic acid
SLC51A(OSTA)
SLC51B(OSTB)
SLCO1B1(OATP2)
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
αLA(Alpha linolenic acid)
ETA(eicosatetraenoic acid)
EPA(eicosapentaenoic acid)
DHA(docosahexaenoic acid)
PGH2
PGI2 PGE2 TX2 LTB2PGD2
5HPETE
2AG(2-Arachidonoylglycerol )
AEA(arachidonoylethanolamide)
PE(phosphatidylethanolamine)
OEA(Oleoyl ethanolamide)
GPR119
20 HETE (20-hydroxyeicosatetraenoic acid)
8-HETE(8-hydroxyeicosatetraenoic acid)
5-HETE(5-hydroxyeicosatetraenoic acid)
13-OXO-ODA
13-HODE
15-HETE9-OXO-ODA
15d-PGJ3(15-deoxy-δ(12,14)-prostaglandin J3)
15d-PGJ2 (15-deoxy-δ(12,14)-prostaglandin J2)
LA(Linoleic acid)
GLA(gannma-linolenic acid)
DGLA(dihomo-gamma-linolenic acid)
AA(arachidonic acid)
PPARs
DHEA(decosahexaenoylethanolamide)
EPEA(eicosapentanoylethanolamide)
PGE3 TX3 LTB3
(5- Hydroperoxyeicosatetraenoic acid)
(13-(S)- hydroxyoctadecadienoic acid) (13-oxo-9,11-octadecadienoic acid)
CNR1, 2
Resolvin
protectin
lipoxin
FAAHn-acyltransferases
NAPEPLD
NAPEDAGLA, B
PLCs
PLDs
ELOVL5
FADS2FADS1
EVOVL5FADS2
ELOV2, 5 FADS2 ACOX1
Circadian rhythm
Anti-inflammation
obesity
Formation of bioactive lipids
PLA1A
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
PPARs
PPARA
PPARGPPARD
n-acyl transferases
AANAT:aralkylamine N-acetyltransferase
NAA10(ARD1A):N(alpha)-acetyltransferase 10, NatA catalytic subunit
GNPNAT1:glucosamine-phosphate N-acetyltransferase 1
HGSNAT:heparan-alpha-glucosaminide N-acetyltransferase
NAA35(MAK10):N(alpha)-acetyltransferase 35, NatC auxiliary subunit
NAT1: N-acetyltransferase 1
NAT2: N-acetyltransferase 2
NAA20(NAT3, NAT5):N(alpha)-acetyltransferase 20, NatB catalytic subunit
NAT6: N-acetyltransferase 6
NAT8:N-acetyltransferase 8 (putative)
NAT8L: N-acetyltransferase 8 like
NAT9: N-acetyltransferase 9 (putative)
NAT10: N-acetyltransferase 10
NAA40(NAT11): N(alpha)-acetyltransferase 40, NatD catalytic subunit
NAA30(NAT12): N(alpha)-acetyltransferase 30, NatC catalytic subunit
NAA50(NAT13): N(alpha)-acetyltransferase 50, NatE catalytic subunit
NAT14:N-acetyltransferase 14 (putative)
NAA60(NAT15): N(alpha)-acetyltransferase 60, NatF catalytic subunit
NAT16: N-acetyltransferase 16 (putative)
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
PLD1, 2, 3, 4, 5, 6PLDs
PLCs
PLCB1
PLCB2
PLCB3
PLCB4
PLCG1
PLCG2
PLCD1
Plcd2
PLCD3
PLCD4
PLCE1
PLCL2 (PLCE2)
PLCZ1
PLCH1
PLCH2
PLCL1
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
Amino Acidα-ketonic acid
Glu2-oxoglutarate
(Arg, His, Pro)
Gln
Amino acid metabolism in liver
citrate
isocitrate
oxaloacetate
malate
fumarate
succinate
Succinyl-CoA
2-oxoglutarate
cis-aconitate
ACLY
ACO2
ACO1, 2
IDH3A, B, G
OGDHCSUCLG1
SDHA, B, C, D
FH
MCCC1, 2
Acetyl CoA
Pyruvate
PDC
TCA cycle
acetoacetate
GPT
PEP
Fatty acid
gluconeogenesis
Ala
GlyCys
Ser
Try
Glu
ArgHis
Pro
Gln
Leu
ME1, 2PCK1, 2
GlycolysisSHMT1, 2
SDSGCAT
GLUD1, 2
Orn
ARG1
OAT
PRODHPRODH2
UROC1
HAL
AMDHD1
GLS
GLS2
Val
Ile
BCAT1, 2IVD HMGCL
Thr
Lys
AADAT
GCDH
Trp
Phe
PAH TATHPD
HGDGSTZ1
FAH
MAT1A MetMAT2A
CBSCTH
CDO1
GOT1
MDH2
AASSALDH7A1
OGDHDLST
ECHS1EHHADH
ACAT1, 2
BCAT1, 2
BCKDHA, BDBT
DLD
ACADSB
IVDACADM
ACADS
HMGCLHMGCLL1HIBADH
ACAA2HMGCS1
OXCT1OXCT2
AACSACAT1
ACAT2ABAT
ALDH6A1
AGXT2
ALDH2
ALDH1B1ALDH9A1ALDH3A2ALDH7A1AOX1
PCCAPCCB
ACSF3
MCEEMUT
IL4I1
ACAD8
ECHS1
MCCC1MCCC2AUHHIBCH
EHHADH
HSD17B10
HADHA, B ACAA1
HMGCS2
MAT2B
DNMT1
DNMT3ADNMT3B
AHCYL1AHCYL2
AHCYCBSL
GOT2MDH1MDH2
CTH
MPSTTST
PYCR1
PYCR2PYCRLALDH4A1
ARG2
FTCD
Asp
AsnASNS
GOT1, 2
NIT2
IL4I1DDO
GLSGLS2 GLUL
NIT2Leu
GOT1, 2IL4I1 AOX1
FAHD1
OGDHL
HADHA
HMGCLL1AUH
ACADM
DBTBCKDHA, B
SDSL
GPT2AGXT AGXT2
GAD1GAD2ABATALDH5A1 GABA
ACMSDHAAO
KYNUKMO
AFMID
TDO2IDO1, 2
HADH
ALDH4A1
ADSSL1ADSSASS1
ADSLASL
Acetoacetyl-CoA
OXCT1, 2HMGCS1, 2
HMGCLHMGCLL1
ACAT1, 2
Acetyl CoA
β-hydroxybutyrateBDH1, 2
α-oxobutyrate(α-ketobutylate)
Propionyl-CoA
Methylmalonyl-CoAMUT
PCCA, BALDH6A1MCEE
BCKDHA, BDBT
ACSS1, 2, 3
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
PDC
DLATDLDPDHA1PDHA2PDHBPDHXPDP1PDP2PDPR
OGDHC OGDH
DLST
DLDoxoglutarate dehydrogenase complexLifeSeq Co. Ltd.
Molecular Map of Obesity and Diabetes
Mitochondrial Shuttles in liver
citrate
isocitrate
oxaloacetate
malate
fumarate
succinate
Succinyl-CoA
2-oxoglutarate
cis-aconitate
ACLY
ACO2
ACO1, 2
IDH3A, B, G
OGDHC OGDHDLST
DLDSUCLG1
SDHA, B, C, D
FH
Acetyl CoA
Pyruvate
PDC
TCA cycle
PEP
DLD
PDHA1 PDHBDLAT
Fatty acid
Glu
ME1-2
PCK1, 2
GLUD1, 2
Pyruvate
MDH2
SLC25A11
SLC1A3
malate
oxaloacetate
MDH2
aspartate
glutamate
alpha-ketoglutarate
GOT2 GOT2
Malate-aspartate shuttle
oxaloacetate
malate
MDH1
Acetyl CoA
aspartate
GOT1
SLC25A1
Malate-citrate shuttle
Dihydroxyacetonephosphate
glycerol-3-phosphate
GPD1
NADH NAD+
GPD2 FADFADH+
Q QH2
glycerol phosphate shuttle
NADH
NAD+
NADH
NAD+
LifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes
PDC
DLATDLDPDHA1PDHA2PDHBPDHXPDP1PDP2PDPR
OGDHC OGDH
DLST
DLDoxoglutarate dehydrogenase complexLifeSeq Co. Ltd. Molecular Map of Obesity and Diabetes