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Ginkgo Biloba extractsDescriptionEUROMED ginkgo biloba extracts are standardized herbal extracsof Ginkgo biloba L. leaves, a “fossil tree” growing in Oriental Asiaand today widely cultivated as medicinal plat in Korea, the south-east of France and the United States.
ChemistryA multitude of polar and apolar compounds have been isolated inginkgo biloba leaves: aliphatic alcohols and keatones, organicacids, sesquiterpenes (bilobalide) and saccharides. Interestingcompounds from the therapeutic point of view are flavonoidscompounds from the therapeutic point of view are flavonoids andditerpenes.The flavonoids are represented by about twenty flavonol glycosides,quercetin and kaempferol 3-rhamnosides and quercetin andkaempferol, and by biflavonoids (amentoflavone, bilobetol, 5-mehoxybilobetol...). Ginkgo biloba leaves also have flavan-3-olsand proanthocyanidins. Ginkgo biloba diterpenes, known asginkgolides A,B, C, J and M, have and hexacylic structurecharacterized by a spiro- [4,4]-nonanic sequence, a tert-butyl group,and three lactones rings.
IndicationsExtracts of ginkgo biloba leaves are proposed to treat the symptonsof senile cerebral insufficiency, memory loss associated with aging,early stages of Alzheimer’s disease, poor circulation to the extremities,intermittent claudication, tinnitus and hearing loss.Ginkgo biloba extracts have antoxidants activity and ability toinhibit platelet aggregation, wich are critical in the prevention ofcirculatory diseases.
Contraindications, interactions and side-effectsGinkgo biloba extract is generally well tolerated, but it iscontraindicated in patients known to be hypersensitive to ginkgobiloba preparations. In less than 1 percent of patients mildgastrointestinal complaints may occur and patients with poor bloodflow may experience a mild, transient headache for the first andsecond days of use.Due to the inhibitory effect on the platelet-activating factor (PAF)if could interact with antithrombotic therapies. Contraindicationsto the use of ginkgo biloba extracs during pregnancy or lactationhave not been reported.
Selected References
Braquet, P. (ed.) Ginkgolides. Chemistry,Biology Pharmacology and clinicalperspectives, Vol. I and II, JR Prous Science,Barcelona (1989)Hagers Handbuch der Drogen undArzneistoffe Springer-Verlag BerlinHeidelberg(2004)Sticher, O.; Hasler, A.; meier, B. DAZ 131(36)1827-35 (1991)www.euromed.es
Denomination
Used plant drug
Used plant parts
Aspect
Identification
Loss on drying
AssayType 1
Type 2
Microbiology
GINKGO BILOBA DRY EXTRACT
Ginkgo biloba L.
Leaves
Fine powder, brown colour
HPLC fingerprint
Max. 5.0%
Ginkgo flavonglycosides min. 24.0 % (HPLC). Terpene lactones min. 6.0% (HPLC)
Ginkgo flavonglycosides 7.5-7.8% (HPLC)
Acc. Ph. Eur. 5.1.4, cat. 3B
Analytical Specifications
EUROMED S.A.Carrer Rec de Dalt 21-23Polígon Can MagarolaE-08100 Mollet del VallèsBarcelona (Spain)Tel. (34) 93 544 0110Tel. (34) 93 544 0111www.euromed.es
EUROMED U.S.A., Inc.11214 Club House RoadNevillewood, PA 15142Tel. +1-412-279 88 08Fax +1-412-279 88 [email protected]
HPLC fingerprint of EUROMED ginkgo biloba by extract
EUROMED France95 Route du Morgon69 400 GleizeTel. +33(0)4 74 60 53 52Fax +33(0)4 74 60 54 [email protected]
EUROMED Canada17240 26A AvenueSurrey, British Columbia V3S 0E6Tel. +1-604-535 44 03Fax +1-604-535 98 [email protected]
EUROMED GermanyLütticher Str. 553 842 TroisdorfTel. +49-221-8998691Fax [email protected]
AU
Ab
ril 2
006