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GENES, ENVIRONMENT AND DIET…. Do these really matter?. Living with autism…. Autism Yesterday. October, 6 th 2009 - USA. Oct. 6 th , 2009 Continued. EARLY DIAGNOSIS - 1. Alarmed by dramatic and baffling rise in the prevalence of autism: - PowerPoint PPT Presentation
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GENES, ENVIRONMENT AND GENES, ENVIRONMENT AND DIET…DIET…
Do these really matter?Do these really matter?
Living with autism….Living with autism….
October, 6October, 6thth 2009 - USA 2009 - USA
Oct. 6Oct. 6thth, 2009 Continued, 2009 Continued
EARLY EARLY DIAGNOSIS - 1DIAGNOSIS - 1
Alarmed by dramatic and baffling rise in the Alarmed by dramatic and baffling rise in the prevalence of autism:prevalence of autism:
Now affects as many as 1 in every 91 (1:57 Now affects as many as 1 in every 91 (1:57 boys) children (3 – 17 yrs of age)!boys) children (3 – 17 yrs of age)!
Though a brain disorder,Though a brain disorder, Current diagnosis is via behavioural Current diagnosis is via behavioural
observations,observations, Which are not reliable until child is 2 to 3 Which are not reliable until child is 2 to 3
yrs old.yrs old.
Early Diagnosis Early Diagnosis - 2- 2
““Finding a sensitive and accurate Finding a sensitive and accurate biological marker for autism that can biological marker for autism that can be revealed by a simple blood test be revealed by a simple blood test would have enormous implications would have enormous implications for diagnosing, treating and for diagnosing, treating and understanding more about the understanding more about the underlying causes of autism,” said underlying causes of autism,” said David G. AmaralDavid G. Amaral,, research director at research director at the UC Davis M.I.N.D. Institutethe UC Davis M.I.N.D. Institute..
Early Early Diagnosis - 3Diagnosis - 3
“ “Not being able to detect autism Not being able to detect autism
until a child is close to 3-years-until a child is close to 3-years-old eliminates a valuable old eliminates a valuable window of treatment opportunity window of treatment opportunity during the first few years of life during the first few years of life when the brain is undergoing when the brain is undergoing tremendous development.”tremendous development.”
EARLY DIAGNOSIS – EARLY DIAGNOSIS – THE GOAL ITHE GOAL I
Discovering an early diagnostic Discovering an early diagnostic test.test.
Imperative of research.Imperative of research. Growing view: Growing view: “Not all children with “Not all children with
autism are ‘doomed to autism’ at birth”.autism are ‘doomed to autism’ at birth”. Vulnerability.Vulnerability. Encounter after being born.Encounter after being born.
Genetic abnormality?Genetic abnormality? Environmental factor?Environmental factor? Dietary issue?Dietary issue?
Triggers the disorder.Triggers the disorder.
EARLY DIAGNOSIS – EARLY DIAGNOSIS –
THE GOAL IITHE GOAL II Studying the biological signs of autism.Studying the biological signs of autism. Could lead to new ways to prevent the Could lead to new ways to prevent the
disorder from ever occurring.disorder from ever occurring. And even if it can’t be prevented,And even if it can’t be prevented, Intervening early in life—ideally shortly Intervening early in life—ideally shortly
after birth—,after birth—, Could Could greatly improvegreatly improve the lifetime the lifetime
outlook for children with autism,outlook for children with autism, Particularly those who now respond Particularly those who now respond
poorly to therapy initiated when they poorly to therapy initiated when they are three or older.”are three or older.”
GENESGENES, , ENVIRONMENT & ENVIRONMENT & DIET - 1DIET - 1 Genes: Genes: May, 2005 –May, 2005 –
chromosomal areas chromosomal areas implicated in Autismimplicated in Autism
5 – 20 genes involved5 – 20 genes involved Location on chromosome Location on chromosome
11 & 1711 & 17 Traits are both biological Traits are both biological
and behaviouraland behavioural Language delayLanguage delay Large head in family Large head in family
membersmembers Abnormal parental Abnormal parental
brain processing of brain processing of facesfaces
Degree to which Degree to which relatives can “read” relatives can “read” person’s mental stateperson’s mental state
GENESGENES, , ENVIRONMENT & ENVIRONMENT & DIET - 2DIET - 2 Genes:Genes: Other – Other –
Left HandednessLeft Handedness Allergies & Immune System Allergies & Immune System
IssuesIssues History of early ear infectionsHistory of early ear infections Food IntolerancesFood Intolerances
Migraine sufferingMigraine suffering Testosterone-link?Testosterone-link?
Combination of Neuro-Combination of Neuro-toxicants & genes account toxicants & genes account for near 25% of for near 25% of Developmental problemsDevelopmental problems National Academy of Sciences - National Academy of Sciences -
20002000
GENES, GENES, ENVIRONMENTENVIRONMENT & & DIET - 3DIET - 3 Environment:Environment:
Children diagnosed with Children diagnosed with autism - increased autism - increased astronomicallyastronomically
Leading scientists Leading scientists concluding - non-genetic concluding - non-genetic factors in the environment factors in the environment may be at least partially may be at least partially responsible for the rise of responsible for the rise of epidemic proportions epidemic proportions world-wideworld-wide
EVIDENCE OF HARMEVIDENCE OF HARM – – [email protected]@yahoogroups.com
Potentially hazardous Potentially hazardous chemicals should be judged chemicals should be judged
“guilty until proven innocent. …“guilty until proven innocent. …But the EPA doesn’t work that But the EPA doesn’t work that
way…”way…”EPA Advisor, Prof. John Wargo, Yale UniversityEPA Advisor, Prof. John Wargo, Yale University
GENES, GENES, ENVIRONMENTENVIRONMENT & & DIET - 4DIET - 4 Environment:Environment:
PCB’s and Language PCB’s and Language Development Development
Environmental factors may Environmental factors may combine with genetic combine with genetic predispositions – 51 over-predispositions – 51 over-lapping geneslapping genes
““Kids at Risk”Kids at Risk” - US News and - US News and World Report, June 19th, 2000 – World Report, June 19th, 2000 – linking chemicals in the linking chemicals in the environment to the rising environment to the rising numbers of children with numbers of children with learning problemslearning problems
1/6 of children in USA suffer 1/6 of children in USA suffer from Autism, ADD/H, Dyslexia or from Autism, ADD/H, Dyslexia or other Learning Disabilitiesother Learning Disabilities
The Normally Developing BrainThe Normally Developing Brain
From uterus throughout adolescenceFrom uterus throughout adolescence
series of complex processes in a series of complex processes in a carefully timed sequencecarefully timed sequence
Cells proliferate, move to correct spot, Cells proliferate, move to correct spot, synapses form, neural circuits are synapses form, neural circuits are refined, neurotransmitters and refined, neurotransmitters and receptors growreceptors grow
Neuro-toxicants may slow, accelerate, Neuro-toxicants may slow, accelerate, or otherwise modify any of these or otherwise modify any of these processes!processes!
GENES, GENES, ENVIRONMENENVIRONMENTT & & DIET - 5DIET - 5 ENVIRONMENTAL ENVIRONMENTAL ISSUE? ISSUE?
AutismAutism in California: 1987 – in California: 1987 – 1998: 210 % increase from 3,164 1998: 210 % increase from 3,164 – 11,995!– 11,995!
Learning ProblemsLearning Problems – New York: – New York: jumped 55% from 132,000 to jumped 55% from 132,000 to 204,000 - 1983 and 1996.204,000 - 1983 and 1996.
The Lead Factor: The Lead Factor: significantly significantly higher bone-lead levels in juvenile higher bone-lead levels in juvenile court convicts – May 2000.court convicts – May 2000.
Breath-taking Pesticides:Breath-taking Pesticides: New New York: pregnant women breath in York: pregnant women breath in at least 3 neuro-toxic pesticides at least 3 neuro-toxic pesticides able to cause disorders in able to cause disorders in foetuses – March, 2000.foetuses – March, 2000.
GENES, GENES, ENVIRONMENTENVIRONMENT & DIET & DIET – 6– 6
““heavy metals”heavy metals”Aluminium Aluminium ToxicityToxicity
Speech disturbanceSpeech disturbanceHesitancyHesitancyStutteringStutteringDisarthriaDisarthriaDyspraxiaDyspraxiaDysphasiaDysphasiaMyoclonic movementsMyoclonic movementsPossible dementiaPossible dementiaDirectional disorientaitonDirectional disorientaitonEpileptic seizuresEpileptic seizuresSenile DementiaSenile DementiaAlzheimersAlzheimersConstipation, colic & nauseaConstipation, colic & nauseaGastric irritationGastric irritationLoss of appetiteLoss of appetiteLocal numbnessLocal numbnessLoss of energyLoss of energyExcessive perspirationExcessive perspiration
Aluminium cooking Aluminium cooking utencilsutencilsSaltsSaltsFood additivesFood additivesAntacidsAntacidsAnti-diarrhoea medsAnti-diarrhoea medsCosmeticsCosmeticsBaking powderBaking powderPharmaceutical and Pharmaceutical and personal hygiene personal hygiene preparationspreparationsSoya baby formulasSoya baby formulasAluminium rich Aluminium rich drinking waterdrinking waterDental fillingsDental fillings
GENES, GENES, ENVIRONMENTENVIRONMENT & &
DIET – 7DIET – 7““heavy metals”heavy metals”CadmiumCadmium Toxic to every human systemToxic to every human system
Biological half-life = 20 – 30 Biological half-life = 20 – 30 years!years!Renal disease Prostatic carcinomaRenal disease Prostatic carcinomaHypertension AnaemiaHypertension AnaemiaSevere pulmonary NauseaSevere pulmonary Nausea and bronchial irritation Sodium retentionand bronchial irritation Sodium retentionNausea VomitingNausea VomitingEmphysema Gastric tract Emphysema Gastric tract irritationirritationImpaired acid secretion Joint pains Impaired acid secretion Joint pains Proteinuria GlycosuriaProteinuria GlycosuriaAminoaciduria Reduced body Aminoaciduria Reduced body temptempElevated erythrocyte clearanceElevated erythrocyte clearanceLoss of taste and touch due to zinc Loss of taste and touch due to zinc deficiencydeficiencyLoss of appetite – zinc deficiencyLoss of appetite – zinc deficiencyLoss of teeth and damage to oral cavityLoss of teeth and damage to oral cavityImpaired adrenal functionImpaired adrenal functionHyperactivity in childrenHyperactivity in children
SMOKING!SMOKING!Saltwater fishSaltwater fishShellfishShellfishBlack teaBlack teaPigments Pigments PaintsPaintsBatteriesBatteriesGalvanised Galvanised pipespipesSolderSolderCar exhaustsCar exhaustsIndustrial Industrial fumes (oil / fumes (oil / coal industry)coal industry)Polluted Polluted waterwater
CARIN S. SMIT – C/CLINICAL METAL CARIN S. SMIT – C/CLINICAL METAL TOXICOLOGIST - SYNAPSE AFRICA NEURO-TOXICOLOGIST - SYNAPSE AFRICA NEURO-
NUTRITIONAL CLINICNUTRITIONAL CLINIC
UraniumUranium Toxic to every human systemToxic to every human systemBiological half-life = 4.5 billion Biological half-life = 4.5 billion years!years!Renal disease Prostatic carcinomaRenal disease Prostatic carcinomaHypertension AnaemiaHypertension AnaemiaSevere pulmonary NauseaSevere pulmonary Nausea and bronchial irritation Sodium retentionand bronchial irritation Sodium retentionNausea VomitingNausea VomitingEmphysema Gastric tract Emphysema Gastric tract irritationirritationImpaired acid secretion Joint pains Impaired acid secretion Joint pains Proteinuria GlycosuriaProteinuria GlycosuriaAminoaciduria Reduced body Aminoaciduria Reduced body temptempElevated erythrocyte clearanceElevated erythrocyte clearanceLoss of taste and touch due to zinc Loss of taste and touch due to zinc deficiency Cancerdeficiency CancerLoss of appetite – zinc deficiencyLoss of appetite – zinc deficiencyLoss of teeth and damage to oral cavityLoss of teeth and damage to oral cavityImpaired adrenal function DeformityImpaired adrenal function DeformityHyperactivity in children Brain injuryHyperactivity in children Brain injury
Thermal Thermal Coal-fired Coal-fired power power plantsplantsNuclear Nuclear reactorsreactorsDepleted Depleted Uranium in Uranium in Ammunition Ammunition and and warheadswarheads
GENES, GENES, ENVIRONMENTENVIRONMENT & DIET & DIET
– 8– 8““heavy metals”heavy metals”
CARIN S. SMIT – C/CLINICAL METAL CARIN S. SMIT – C/CLINICAL METAL TOXICOLOGIST - SYNAPSE AFRICA NEURO-TOXICOLOGIST - SYNAPSE AFRICA NEURO-
NUTRITIONAL CLINICNUTRITIONAL CLINIC
Courtesy: Gethin Chamberlain – UK Guardian
GENES, GENES, ENVIRONMENTENVIRONMENT & &
DIET – 8DIET – 8““heavy metals”heavy metals”MercuryMercury HIGHLY TOXIC TO HUMANS HIGHLY TOXIC TO HUMANS
– Inhibits enzyme activity– Inhibits enzyme activity!!Worldwide production – Worldwide production – exceeds 10,000 tons p/aexceeds 10,000 tons p/aCNS disorders and paralysis CNS disorders and paralysis Destroys red blood cells Destroys red blood cells Birth defectsBirth defectsCauses chromosomal damage Metallic taste Causes chromosomal damage Metallic taste Loss of appetite and weight Loss of appetite and weight Inflamed gums and loose teeth and Inflamed gums and loose teeth and Skin irritationsSkin irritationsIncreased salivation IrritabilityIncreased salivation IrritabilityHyperactivity Blushing Hyperactivity Blushing Increased blood pressure PsychosesIncreased blood pressure PsychosesDepression Loss of energy AllergiesDepression Loss of energy AllergiesHallucinations Ataxia Hallucinations Ataxia Asthma Asthma Convulsions Convulsions Extreme tremorExtreme tremorAcute mental and emotional Kidney failureAcute mental and emotional Kidney failureDisordersDisorders
Frequent Frequent consumption of consumption of large fish – e.g. large fish – e.g. tunatunaPlasticPlasticPrinter’s inkPrinter’s inkPigmentsPigmentsCosmeticsCosmeticsPesticidesPesticidesDental Dental amalgamsamalgamsFabric Fabric softenerssoftenersChlorine bleachChlorine bleachGrains treated Grains treated with fungicideswith fungicidesVaccinationsVaccinations
GENES, GENES, ENVIRONMENTENVIRONMENT & &
DIET – 9DIET – 9““heavy metals”heavy metals”LeadLead HIGHLY TOXIC – Inactivates HIGHLY TOXIC – Inactivates
enzymesenzymes!!Renal, CNS Renal, CNS (AFFECTS EMOTIONAL (AFFECTS EMOTIONAL AND PHYSICAL HEALTH – REDUCES AND PHYSICAL HEALTH – REDUCES INTELLECTUAL CAPACITY)INTELLECTUAL CAPACITY), , endocrine, immune and endocrine, immune and hemopoietic damagehemopoietic damage: : Fatigue Fatigue (anaemia), Constipation, Abdominal pain, (anaemia), Constipation, Abdominal pain, Anorexia, Altered sleep patterns, Irritability, Anorexia, Altered sleep patterns, Irritability, DiarrhoeaDiarrhoeaNausea, Headaches,Nausea, Headaches,Vertigo, Tremor, Vertigo, Tremor, Joint pain, Psychoneuroses, Colic, Loss of Joint pain, Psychoneuroses, Colic, Loss of muscle strength, muscle strength, Paresthesia, Paresthesia, Neuropathy and encephalopathy, Aggression Neuropathy and encephalopathy, Aggression during adolescence,during adolescence,Mental retardation, learning disabilities, Mental retardation, learning disabilities, speech disturbance, speech disturbance, Intermittent fever, DehydrationIntermittent fever, DehydrationADVANCED STAGE: LETHAL!ADVANCED STAGE: LETHAL!
Leaded petrol Leaded petrol (gasoline) – (gasoline) – 600,000 tons p/a 600,000 tons p/a into atmosphere!into atmosphere!Lead paint – bitter Lead paint – bitter legacy of legacy of governmental governmental failure to act!failure to act!Burning coalBurning coalSmelting worksSmelting worksBatteries Batteries PigmentsPigmentsPotteryPotteryCrystalCrystal
GENES, GENES, ENVIRONMENT & ENVIRONMENT & DIETDIET - 1- 1 WHY DIET?WHY DIET?
Genetic Genetic predisposition to predisposition to weak digestionweak digestion
Enzyme Enzyme suppressing suppressing environmental environmental insultsinsults
Foods which Foods which suppress suppress enzymatic functionenzymatic function
GENES, GENES, ENVIRONMENT & ENVIRONMENT & DIETDIET - 2- 2 Family history of Family history of
digestive problemsdigestive problems Heavy metals Heavy metals
suppress enzyme suppress enzyme functionfunction
Certain foods Certain foods contain chemicals contain chemicals which suppress which suppress pancreatic pancreatic enzymesenzymes
GrainsGrains DairyDairyLegumes, Legumes,
Nuts, Seeds Nuts, Seeds & Pulses& Pulses
Gluten(60)/Gluten(60)/Gliadin(40)Gliadin(40)
CaseinCasein Gliadin(100)Gliadin(100)
Gluta-Gluta-morphinemorphine / / Gliadino-Gliadino-morphinemorphine
Caso-Caso-morphinemorphine
Gliadino-Gliadino-morphinemorphine
Amino AcidsAmino Acids Amino AcidsAmino Acids Amino AcidsAmino Acids
HOW PROTEINS BREAK DOWN…
GENES, GENES, ENVIRONMENT & ENVIRONMENT & DIET DIET - 3- 3
GF/CF GF/CF versusversus HistoricallyHistorically – milk – milk
& wheat& wheat ThenThen all gluten- all gluten-
containing containing products and products and dairydairy
ThenThen lists of lists of gluten and gluten and casein-containing casein-containing foodsfoods
GF/C/F/GF/C/F/G/FG/F THE PROBLEM:THE PROBLEM:
All grains contain All grains contain gluten & most gluten & most contain gliadin toocontain gliadin too
Gliadin is the Gliadin is the toxic toxic protein that protein that causes coeliacs causes coeliacs to lose endothelial to lose endothelial cells!cells!
100% of protein in 100% of protein in legumes, nuts, legumes, nuts, seeds and pulses seeds and pulses is is GLIADINGLIADIN!!
“There are three kinds of lies: lies, damn lies and statistics…”Benjamin Disraeli, 1804 - 1881
GENES, GENES, ENVIRONMENT & ENVIRONMENT & DIETDIET - 5 - 5
““Lies, damn lies Lies, damn lies and statistics…” and statistics…” – – Pinnochio Pinnochio syndrome!syndrome!
Soya, Nuts, Soya, Nuts, Seeds, Milk, Seeds, Milk, Grains – are Grains – are they good for they good for you?you?
What is there What is there to loseto lose?!?!
GENES, GENES, ENVIRONMENT & ENVIRONMENT & DIETDIET - 4- 4 LEGUMESLEGUMES – –
Soya i.s.o. Milk!Soya i.s.o. Milk! Nuts, Seeds Nuts, Seeds
and pulsesand pulses - - as alternative as alternative protein protein sources???sources???
““NO! No! NO! No! No!”No!”
GENES, GENES, ENVIRONMENT &ENVIRONMENT & DIETDIET - 5- 5 Nutrients LostNutrients LostCalciumCalciumMagnesiumMagnesiumZincZincB-ComplexB-ComplexEssential aminoEssential aminoacidsacidsEssential fatty acidsEssential fatty acidsTrace elementsTrace elementsVitamin CVitamin C
WHY DIET?WHY DIET? Clears brain of opiates (morphines)Clears brain of opiates (morphines) Improves appetite for other foods – wider Improves appetite for other foods – wider
food choicesfood choices StopsStops neural pruning whilst heavy metals neural pruning whilst heavy metals
issues are being addressedissues are being addressed StopsStops insults to immune system (WBC’s & insults to immune system (WBC’s &
DPPIV)DPPIV) StopsStops mineral-leeching (Ca, Mg, Zn…) mineral-leeching (Ca, Mg, Zn…) Makes body feel better – health benefitsMakes body feel better – health benefits Heals gastro-intestinal systemHeals gastro-intestinal system Improves mood, focus and memoryImproves mood, focus and memory StopsStops mal-digestion, malabsorption and mal-digestion, malabsorption and
malnutritionmalnutrition
METALLOTHIONEIN – METALLOTHIONEIN – WHAT IT IS AND WHAT IT WHAT IT IS AND WHAT IT
DOES?DOES? Body’s control mechanism for
copper and zinc Development of neurons Detoxifies heavy metals Matures the GI tract Anti-oxidation Boosting immune function Delivers zinc to cells
METALLOTHIONEIN-METALLOTHIONEIN-RELATED ISSUES IN RELATED ISSUES IN
AUTISMAUTISM Incomplete breakdown of Incomplete breakdown of
casein/gluten/gliadin protein by zinc casein/gluten/gliadin protein by zinc dependent enzymesdependent enzymes
Disrupted ability to combat yeastDisrupted ability to combat yeast Reduced production of stomach acidReduced production of stomach acid Impaired stimulation of pancreas by Impaired stimulation of pancreas by
secretinsecretin Leaky gut syndromeLeaky gut syndrome Inability to clear body of Inability to clear body of heavy metalsheavy metals Disordered immune systemDisordered immune system Neurological changes we ultimately see in Neurological changes we ultimately see in
AutismAutism
11 HELPFUL BIO-MECIDAL SCREENING – HELPFUL BIO-MECIDAL SCREENING – Checking metabolism Mineral Hair Analysis – Micro Trace Minerals Lab - Germany Urinary Chelation Tests – Micro Trace Minerals Lab - Germany Advanced Metallothionein Profile – Great Plains - USA Organic Acid Testing – Great Plains USA Urinary Peptide Analysis – University of Oslo – Norway (Other: Porphyrin Testing / Comprehensive Allergy Test, etc)
22 INITITAL CONSULTATION – INITITAL CONSULTATION – Recommendations given to commence appropriate sensory-motor integration therapies and employ methods to advance general detoxification: Auditory Integration Training Magnesium-Sulphate baths Jogging, bouncing which enhance cardio-vascular function Neuro-Cognitive Mobilisation – brain-stem activation Have water tested for toxicity – switch to “good” water i.s.o. other drinks
33 FOLLOW-UP CONSULTATION REGARDING FOLLOW-UP CONSULTATION REGARDING FINDINGS: FINDINGS: Plan a follow-up consultation within 8 weeks of initial bio-medical screening tests (personal or tele-conferencing) Discuss yeast & fungal eradication, Diet & Super-nutrition; Methylcobalamin- injections, MT Promoter (?), chelation. Management plan for further therapeutic interventions.
44 COMMENCE YEAST / FUNGAL ERADICTION & COMMENCE YEAST / FUNGAL ERADICTION & ENSURE OPTIMAL MINERAL AND TRACE ELEMENT ENSURE OPTIMAL MINERAL AND TRACE ELEMENT STATUS STATUS
55 COMMENCE CHELATION – COMMENCE CHELATION – Oral or Intravenous – liver Oral or Intravenous – liver and kidney function tests.and kidney function tests.
66 IMPERATIVE: IMPERATIVE: Follow-up tests EVERY 3 – 6 MONTHSFollow-up tests EVERY 3 – 6 MONTHS Mineral Hair Analysis, Urinary chelation, AMP, Organic Mineral Hair Analysis, Urinary chelation, AMP, Organic Acids, Iron StoresAcids, Iron Stores