Galen B · Web viewThe Probiotics Revolution, Huffnagle GB and Wernick S, Thinkingdom Media Group LTD, China (Hardcover, 2008) - Chinese translation The Probiotics Revolution, Huffnagle

Gary B. Huffnagle, Ph. D.Professor of Internal Medicine

Professor of Microbiology and ImmunologyDivision of Pulmonary and Critical Care Medicine

University of Michigan Health System1150 W. Medical Center Drive, 6301 MSRB III

Ann Arbor, MI, 48109-0642(734) 936-7934; fax (734) 764-2655

[email protected]

Title and Contents 1

Education and Training 2

Academic, Administrative, and Clinical Appointments 2

Research Interests 3

Grants 3

Honors and Awards 6

Memberships in Professional Societies 6

Editorial Positions, Boards, and Peer-Review Services 7

Teaching 9

Committee, Organizational, and Volunteer Services 12

Visiting Professorships, Seminars, and Extramural Invited Presentations 13

Bibliography 19

Gary B. Huffnagle, Ph.D. October 2011 1

mailto:[email protected]

Gary B. Huffnagle, Ph. D.Professor of Internal Medicine

Professor of Microbiology and ImmunologyDivision of Pulmonary and Critical Care Medicine

University of Michigan Health System1150 W. Medical Center Drive, 6301 MSRB III

Ann Arbor, MI, 48109-0642(734) 936-7934; fax (734) 764-2655

[email protected]

Education and Training

9/80-5/84 Pennsylvania State University, University Park, PAB. S. (Honors in Microbiology)

9/84-9/90 University of Texas Southwestern Med. Ctr., Dallas, TXPh. D. (Immunology)

Postdoctoral Training10/90-6/92 University of Texas Southwestern Med. Ctr., Dallas, TX;

Department of Pathology, Immunopathology

Academic, Administrative, and Clinical Appointments

Academic Appointments

6/92-8/97 Research Investigator, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center

8/97-8/00 Assistant Research Scientist, Division of Pulmonary and Critical Care Medicine, Dept. of Internal Medicine, University of Michigan

9/99-8/00 Assistant Research Scientist, Department of Microbiology/ Immunology, University of Michigan

9/00-8/02 Senior Associate Research Scientist & Associate Professor (without tenure), Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan

9/00-8/02 Associate Professor (without tenure), Department of Microbiology/ Immunology, University of Michigan

9/02-9/06 Associate Professor (with tenure), Div. of Pulmonary and Critical Care Medicine, Dept. of Internal Medicine, University of Michigan

9/02-9/06 Associate Professor (with tenure), Department of Microbiology/ Immunology, University of Michigan

9/06-current Professor, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan

9/06-current Professor, Department of Microbiology and Imunology, University of Michigan


mailto:[email protected]

Research Interests

1. pulmonary2. mucosal3. gastrointestinal4. immunology5. inflammation6. infection7. allergy8. asthma9. microbiota10. microflora11. fungi12. probiotics

Grants

Present and ActiveNational Institutes of Health (1R01HL114447) "Pulmonary bacterial microbiome-epithelial cell interactions in COPD"Principal Investigator (multi-PI) 6/1/2012-5/31/2016 ($1,000,000 total direct costs)

National Institutes of Health (4UH3DK083993) “The Role of the Microbiota in Ulcerative Colitis” Co-investigator 6/24/09-5/31/13 ($8,500,000 total direct costs)

National Institutes of Health (1U01HL098961) “Understanding the Lung Microbiome in HIV-Infected and HIV-uninfected individuals” Co-investigator 9/23/09-7/31/14 ($2,450,000 total direct costs)

National Institutes of Health (U19AI090871) “Enteric Research Investigational Network (ERIN) – Clostridium difficile Cooperative Research Center” Principal Investigator Project #3: Host Defense 7/1/10-6/30/15 ($5,000,000 total direct costs for all 3 ERIN projects)

National Institutes of Health (1R21AI087869) "The role of the microbiome in the development/prevention of food allergies"Principal Investigator 9/1/2010-8/31/2012 ($275,000 total direct costs)

National Institutes of Health (2 P30 DK034933) “Gastrointestinal Hormone Research Core Center” Microbiome and Inflammation Core Co-director 12/1/2010-11/30/2015 ($500,000 total direct costs for core)


Previous GrantsNational Institutes of Health (R01-AI064479), “Role of Fungal Microflora in Mucosal Tolerance/Immunity.” Principal Investigator; 4/1/05-3/31/11 ($1,250,000 total direct costs)

National Institutes of Health (1R21-AI064479) “Mucosal Mechanisms Linking Pulmonary and Gastrointestinal Inflammation/Immunity” Principal Investigator; 7/26/09-7/25/11 ($275,000 total direct costs)

National Institutes of Health (R01-HL077417), "Regulation of Pulmonary Host Defense by Leptin." Co-Investigator; 1/1/06 - 12/31/10 ($1,000,000 total direct costs)

Abbott Nutrition, "The Use of a Murine Model for Screening Probiotics, Prebiotics and Nutritional Interventions for their Effectiveness in Reducing the Risk of Allergic Airway Disease." Principal Investigator; 6/30/08-12/30/09 ($63,000)

National Institutes of Health (R01-AI059201), “Oxylipins in Cryptococcal Pathogenesis.” Principal Investigator; 2/1/04-1/31/09 ($1,250,000 total direct costs)

National Institutes of Health (R01-HL51082), “Macrophage Recruitment/ Activation in Lung Defense.” Co-Investigator; 6/1/03-5/30/09, ($1,250,000 total direct costs)

National Institutes of Health, (R01-HL65912), “Modulation of Th1/Th2 Responses by Innate Immunity,” Principal Investigator, 9/1/00-8/31/05, ($1,000,000 total direct costs)

Francis Families Foundation, Parker B. Francis Pulmonary Fellowship Mentor (Mairi Noverr, PhD, fellow) 7/1/05-6/31/08 ($132,000)[Transferred on 10/1/05 because Dr. Noverr accepted a faculty position at Wayne State Medical School]

National Institutes of Health, (R01-HL63670), "Chemokine receptors in immunity to C. neoformans."Principal Investigator, 7/1/99-6/30/04, ($875,000 total direct costs)

National Institutes of Health (RO1-HL51082), “Macrophage recruitment/ activation in lung defense.” Co-Investigator; 12/1/97-11/30/02, ($1,365,113 total direct costs)


National Institutes of Health, (P50HL060289, SCOR in Acute Lung Injury), “Effect of sepsis on lung antibacterial host defenses.” Co-Investigator; 12/1/98-11/30/03, ($945,000 total direct costs)

University of Michigan Department of Internal Medicine Pilot Grant Program, “Lactobacillus-Candida Interactions: Biology and Mechanisms.” Principal Investigator 1/01/03-12/31/04, ($40,000)

Francis Families Foundation, Parker B. Francis Pulmonary Fellowship Mentor (Timothy Traynor, PhD, fellow) 7/1/00-6/31/03 $120,000 [Transferred on 6/15/01 because Dr. Traynor accepted a faculty position at Washington State University Veterinary School]

Burroughs-Wellcome Fund, (New Investigator Award in Pathogenic Mycology), “The role of melanin production by Cryptococcus neoformans in evasion of host defenses.” Principal Investigator; 7/1/98-6/30/02, ($195,000 total direct costs)

National Institutes of Health (R29-AI38190), “The role of TNFin T cell immunity to C. neoformans.” Principal Investigator, 9/1/95-8/31/00, ($350,000 total direct costs)

Michigan Memorial Phoenix Project, “The role of macrophage inflammatory protein-1 (MIP-1) in pulmonary inflammation.” Principal Investigator; 12/1/92-11/30/93, ($6,000)

Francis Families Foundation- Parker B. Francis Pulmonary Research Award “The role of macrophage inflammatory protein-1 (MIP-1) in pulmonary inflammation.” Senior Fellow, 7/1/93-6/30/96, ($102,000)

University of Michigan Geriatrics Center Pilot Grant “T cell mediated host defenses in the lungs of aged mice.” Principal Investigator; 1/1/95-12/31/95, ($20,000)

University of Michigan Geriatrics Center Pilot Grant, “Effect of aging on cell-mediated immunity in the lungs.” Principal Investigator; 6/1/97-8/31/98, ($20,000)

Undergraduate Fellowship Sponsor:Biomedical Research Council (Lisa McNeil):5/94-8/94, $2,500Biomedical Research Council (Michael Boyd):5/94-8/94, $2,500Howard Hughes Medical Foundation (Lisa McNeil):


5/95-8/95, $2,500Howard Hughes Medical Foundation (Michael Boyd):5/95-8/95, $2,500Biomedical Research Council (Ryan Fajardo): 7/95-9/95, $2,500Biomedical Research Council (Lori Dargurz):5/96-8/96, $2,500Biomedical Research Council (Lauren Pray):7/96-9/96, $2,500Biomedical Research Council (Andrea Bediako):5/97-8/97, $2,500Biomedical Research Council (Deirdra Williams):5/97-8/97, $2,500Biomedical Research Council (Adam Dumas):5/99-8/99, $3,500Biomedical Research Council (Anne Hartmann):5/99-8/99, $3,500Biomedical Research Council (Elaine Te-Yie Huang):5/01-8/01 $3,500Biomedical Research Council (P. Anne Poole):5/03-8/03 ($3,500)Biomedical Research Council (Jeff Hopcian) 5/06-8/06 ($3,500)

Honors and Awards

1993 Clinical Immunology Society: Young Investigator Award1993 Parker B. Francis Pulmonary Research Award1998 Burroughs-Wellcome Fund, New Investigator Award in Pathogenic

Mycology2008 American Society for Microbiology Division F (Medical Mycology)

Lectureship2010 University of Michigan Faculty Recognition Award

Memberships in Professional Societies

1994-current American Association of Immunologists (AAI)1995-current American Society for Microbiology (ASM)2007-2008 Chair Elect, ASM Div F (Medical Mycology)2008-2009 Chair, ASM Div F (Medical Mycology)2009-2010 Advisor, ASM Div F (Medical Mycology)

Editorial Positions, Boards, and Peer-Review Services

Editorial Boards1998-2002 Associate Editor, the Journal of Immunology2002-2006 Section Editor, the Journal of Immunology


2003-2008 Editorial Board, Infection and Immunity2004 Associate Editor, Medical Mycology

Manuscript Reviewer (approximately 30/year): Journal of Immunology, American Journal of Respiratory Cell and

Molecular Biology, American Journal of Pathology, Journal of Infectious Diseases, Journal of Clinical Investigation, Infection and Immunity, Clinical and Experimental Immunology, FEMS Letters, Biochimica Biophysica Acta, Journal of Bacteriology, Nature Reviews, Cell Host & Microbe, Eukaryotic Cell, American Journal of Gastroenterology, American Journal of Respiratory & Critical Care Medicine, Cell Host & Microbe, Medical Mycology, ISMEJ, PLoS

Study Sections (Permanent member, National Institutes Of Health, Bethesda, Md)2002-2005 NIH, Bacteriology/Mycology Study Section 2 (BM-2) and Pathogenic

Eukaryotic Microbiology (PTHE) {study section re-organized and re-named in 2004} – Review Committee, Center for Scientific Review

2010-current Center for Scientific Review (CSR), College of Reviewers2012-current NIH, Immunology & Host Defense Study Section (IHD)- Review

Committee, Center for Scientific Review (appointment through 2018)

Study Sections (ad hoc, National Institutes of Health, Bethesda, MD)1998 NIH, AIDS Research - Review Committee, National Institute of

Allergy and Infectious Diseases1998 NIH, Mycology Program Projects - Review Committee, National

Institute of Allergy and Infectious Diseases1999 NIH, Models of HIV Infection - Review Committee, National Heart

Lung Blood Institute2000 NIH, Vaccine Immunology - Review Committee, National Institute of

Allergy and Infectious Diseases2000 NIH, Immunology of Orapharyngeal Candidiasis - Review Committee,

National Institute of Dental and Craniofacial Research2000 NIH, Members Conflict Special Emphasis Study Section - Review

Committee, Center for Scientific Review2001 (Mar) NIH, Bacteriology/Mycology Study Section 2 (BM-2) – Review

Committee, Center for Scientific Review2001 (Oct) NIH, Bacteriology/Mycology Study Section 2 (BM-2) – Review

Committee, Center for Scientific Review2002 (Feb) NIH, Bacteriology/Mycology Study Section 2 (BM-2) – Review

Committee, Center for Scientific Review2003 NIH, Conflict Special Emphasis Study Section - Review Committee,

Center for Scientific Review (Chair)2004 NIH, Mycology Program Projects - Review Committee, National

Institute of Allergy and Infectious Diseases


2005, 2007 NIH, Conflict Special Emphasis Study Section - Review Committee, Center for Scientific Review

2006 NIH, Conflict Special Emphasis Study Section - Review Committee, Center for Scientific Review (Chair)

2007, 2008 NIH, Pathogenic Eukaryotic Microbiology (PTHE) – Review Committee, Center for Scientific Review

2007, 2008 NIH, NHLBI P01 review study section2008, 2009 NIH, Special Emphasis Study Section (Microbiome Roadmap / New

Technologies RFA) - Review Committee, Center for Scientific Review 2009 NIH, RC1 Challenge Grant remote review2009, 2010 NIH, AIDS & Opportunistic Diseases Study Section (AOIC) – Review

Committee, Center for Scientific Review2010 NIH, P01 program in Allergic Diseases, Review Committee, National

Institute of Allergy and Infectious Diseases 2010 NIH, Metagenomics of Orapharyngeal Diseases - Review Committee,

National Institute of Dental and Craniofacial Research (Chair)2010 NIH, Conflict Special Emphasis Study Section - Review Committee,

Center for Scientific Review2010 NIH, CSR College of Reviewers2011 NIH, NHLBI P01 Special Emphasis Panel – Review Committee2011 NIH, NIAID Asthma and Allergic Diseases Cooperative Research

Centers (AADCRC) – Review Committee2011 NIH, NIDDK Special Emphasis Panel – Review Committee2011, 2012 NIH, CSR - Ad hoc reviewer, Immunology & Host Defense (IHD)

study section2011 NIH, NIEHS - Dietary Influence on the Human Health Effects of

Environmental Exposures - Review Committee2011 NIH, CSR - Population Sciences and Epidemiology (PSE) Integrated

Review Group - R15 application reviews (Ad hoc)

Grant Reviewer (ad hoc)1992 American Heart Association.1993 British Columbia Lung Association1994-2005 Department of Veterans Affairs1996 British Columbia Health Research Foundation2000 Louisiana State University Board of Regents2001-2006 Alberta Heritage Medical Research Foundation2004 Wellcome Trust, England2007 Singapore National Medical Research Council2009 Ludwig Boltzmann Institutes, Austria: “Role of the Microbiome in

Disease”- Review Committee2010 European Commission’s 7th Framework Programme for Research:

“Infection and dysbiosis as the triggers of the development of inflammatory processes in allergies and autoimmune diseases” - Review Committee

2010 Natural Environmental Research Council – United Kingdom


2010 Biotechnology and Biological Sciences Research Council – United Kingdom

2010 Wellcome Trust, United Kingdom

Government Review Panels and Advisory Committees2004 Department of Defense, Innate Immunity in Biodefenses, Center for

Technology and National Security Policy, National Defense University2007 NIH, National Human Genome Research Institute, the Microbiome in

Health and Disease2007 NIH, NHLBI, the Microbiome in Pulmonary Disease2008 NIH, NIAID, Helicobacter Pylori Workshop2011 NIH, NIHGRI Director’s Advisory and Ideas Meeting: Human

Microbiome Research Initiative2011 NIH, NHLBI Human Lung Microbiome Workshop and Advisory

Panel

Non-government Advisory Committees2008-2010 Ganeden Biotech, Scientific Advisory Board

Teaching

National1986-1988 Teaching Assistant, Medical Microbiology,

UT Southwestern Medical School, Dallas, TX1988-1992 Lecturer, Tumor Immunobiology

UT Southwestern Graduate School, Dallas, TX1998 External Examiner: Doctoral Dissertation Committee (Rachel Syme),

University of Calgary, Alberta, Canada1999 Invited Lecturer, Microbial Pathogenesis Course

Duke University, Durham, NC2004 External Examiner: Doctoral Dissertation (Rosie Santangelo),

University of Sydney, Australia2006 External Examiner: Doctoral Dissertation (Joanna Zhou), University of

Nevada, Reno, NV2009 University of Michigan Retirees Association, "Probiotics, Prebiotics &

Human Health", Ann Arbor, MI

University Of Michigan

Undergraduate Courses 2000-2003 Microbiology 505 “Introduction to Infectious Diseases,”

Course Director and Primary Lecturer (3 cr)2005-2009 Microbiology 460 / Internal Medicine 460

"Eukaryotic Microbology and Microbial Symbiosis," Course Director/Instructor (3 cr)

2010, 2011 Microbiology 460 / Internal Medicine 460


"Eukaryotic Microbology," Lecturer

Graduate Courses2000, 2005-2008, 2010 Immunology 850 “Advanced Immunology”

Course Director and Instructor (2 cr)2001-2004 Immunology 815 “Immunology Student Seminars”

Course Director (1 cr) 2006 Microbiology 512/Pharmacology 502 “Grant Writing"

Faculty group leader/reviewer (2 cr)

Graduate Lectures2002 Immunology 850 “Immunity to Infection” 2004 School of Public Health - "The Epidemiological Links between

Infection and Chronic Disease”2006, 2007 School of Public Health - "The Hygiene Hypothesis”2007 Immunology 851 “Mucosal Immunology”2009 NHLBI T32 Basic science core curriculum: Multi-disciplinary training

program in pulmonary diseases - "Flow Cytometry" & "Cell Culture"

Program Membership1999-current Microbiology Graduate Program1999-2010 Immunology Graduate Program1993-current University of Michigan Undergraduate Research Opportunity Program

(UROP)2004-current Interdepartmental Undergraduate Microbiology Concentration

Steering Committee (Chair, 2005-current)

Undergraduate Mentorship1993-current Michael Boyd (1993-96) Lisa McNeil (1993-96)

Ryan Fajardo (1993-96) Nicola Bolf (1995)Lauren Pray (1995-98) Lori Dargurz (1995-96)Chrystie Dronjseko (1996) David Petrovski (1996)Andrea Bediako (1996-1999) Deirdra Williams (1996-2000)Anne Hartmann (1998-2001) Cara Christman (1998-2000)Elaine Te-Yie Huang (1998-2002) Adam Dumas (1998-1999)Zack Leshen (1999-2000) Danielle Bracy (2000)Stephanie Dionne (2001) Nicole Robson (MS, 2001-2002)P. Anne Poole (2003) Rishi Surana (2002-2006)DeAndrea Fedrick (2003) Mia Lui (2002-2004)David McNamara (2005-2007) James Kozich (2007-2008)Kelly Mason (2008-2010) Ryan Pakula (2009)Lauren Miller (2010-2011) Ryan Muraglia (2012)


Kathryn Higdon (2012) Zachary Britt (2012-2013)Charles Frank (2012-current) Chinmay Pandit (2012-current)

Medical Student MentorshipJeff Hopcian (2006)

Graduate Mentorship1999-2002 Ph. D. Dissertation Mentor for Mairi Noverr (Microbiology/Immunology)2000-2003 Ph. D. Dissertation Mentor for Yadira Hernandez

(Microbiology/Immunology)2000-2004 Ph. D. Dissertation Mentor for Dennis Lindell (Immunology)2000-2005 Ph. D. Dissertation Mentor for John Erb-Downward

(Microbiology/Immunology)2002-2005 Ph. D. Dissertation Mentor for Shikha Arora (Immunology)2002-2007 Ph. D. Dissertation Mentor for Toby Rodriguez

(Microbiology/Immunology)2005-2008 Ph. D. Dissertation Mentor for Andrew Shreiner (MSTP, Immunology)2006-2010 Ph. D. Dissertation Mentor for Katie Mason (Microbiology/Immunology)2007-2010 Ph. D. Dissertation Mentor for Ben Murdock (Immunology)2011-current Ph. D. Dissertation Mentor for Brittan Scales (Microbiology/Immunology)2011-current Ph. D. Dissertation Mentor for Andrew McDermott

(Microbiology/Immunology)

Post-doctoral Fellow Mentorship1997-1999 Research Fellowship Mentor for John Lee, M.D.1998-2003 Research Fellowship Mentor for Michal Olszewski, D.V.M., Ph.D.1998-2001 Research Fellowship Mentor for Tim Traynor, Ph.D.1999-2002 Research Fellowship Mentor for Raj Pandrangi, Ph.D.1999-2003 Research Fellowship Mentor for Amy Herring, Ph.D.2001-2002 Research Fellowship Mentor for Jill Kolodsick, Ph.D.2002-2005 Research Fellowship Mentor for Mairi Noverr, Ph. D.2005-2007 Research Fellowship Mentor for Jami Milam, Ph. D.2005-2008 Research Fellowship Mentor for John Erb-Downward, Ph. D.2008-2009 Research Fellowship Mentor for Mary Pat Craver, Ph. D.2009-2011 Research Fellowship Mentor for Michael Shen, M. D.2009-2012 Research Fellowship Mentor for Merritt Gillilland III, Ph. D.2012-current Research Fellowship Mentor for Robert Dickson, M. D.

Graduate Program Student Committees2000-current Microbiology/Immunology Graduate Program, Preliminary Exam

Committees:Nancy Beck Becky Wiesner Brendan ThomasonJess Siple Nathan Fisher Ari MolofskyRyan Mihalik Lisa Gralinski Miranda Gray


Patrick Virgil Shandee Dixon Will DePas2011 exams (4 students)

2001 Biomedical Engineering Graduate Program, Preliminary Exam Committee:Seema Bajaria

2002-2005 Immunology Graduate Program, Preliminary Exam Committees:Rebecca Henry Katie JohnsonMatt Schaller Kelly SeidlChun-Shu Wong

2001-current Dissertation Committees:Brendan Thomason (PhD, Micro/Imm) - defended 10/2005Steve Cendrowski (PhD, Micro/Immun) - defended 8/2004Sharlene Moore (MS, Epidemiology) – defended 12/2002Gabriel Maine (PhD, Immunology) - defended 12/2004Laura Rozen (PhD, Chemistry) – defended 12/2002Scott Berger (PhD, Biochemistry) - defended 10/2005Ping Ye (PhD, Microbiology/Immunology) – defended 6/2003Seema Bajaria (PhD, Biomed. Engineering) - defended 12/2004Rebecca Henry (PhD, Immunology) - defended 12/2004Ari Molofsky (PhD, Micro/Immun) - defended 6/2005Matt Schaller (PhD, Immunology) - defended 11/2005Andrew Hsu (MS, Nutrition) - defended 4/2005Brian Heffernan (PhD, Micro/Immun) – defended 12/2006Megan Ballinger (PhD, Immunology) – defended 12/2006Helen Lau (PhD, Micro/Immun) - defended 6/2007Christian Ray (PhD, Micro/Immun)- defended 10/2007Bryna Burrell (PhD, Immunology) - defended 12/2007Laura Delbridge (PhD, Microbiology) - defended 1/2009Heather O'Malley (PhD, Pharmacology) - defended 8/2009Adam Hartigan (PhD, Immunology) - defended 6/2009Lindsay Davis (PhD, Microbiology/Immunology) - defended 3/2010Hemanth Ramaprakash (PhD, Immunology) - defended 4/2010Gitanjali Kundu (PhD, Wayne State Med. School, Imm & Micro) – defended 7/2010Tiffany Tsang (PhD, Microbiology/Immunology) – defended 12/2010Marta Hernandez-Gonzalez (PhD, Immunology) - defended 8/2012Angela Hopkinson (PhD, Microbiology/Immunology) - defended 7/2012Kelly Schwartz (PhD, Molec Cell Develop Biol)Joe Zakular (PhD, Microbiology/Immunology)

2001-current Additional Graduate Laboratory Research RotationsRebecca Wiesner Ari MolofskyChristian Ray Eric Komuniecki


Megan Ballinger Brittany ShawZach Dalebroux Tiffany TsangMargarita Hernandez Kelly SchwartzJulia Wu

Committee, Organizational, and Volunteer Services

National1996-1999 American Thoracic Society Program Committee (MTPI)2007 American Society for Microbiology, Division F Program Committee2007-2009 American Society for Microbiology, Division F

Chair-elect/Chair/Advisor

University Of Michigan1993-current Undergraduate Research Opportunity Program (UROP)1998-2001 Advisory Committee on Primary Research Appointments, Promotions and

Titles (APRAPT) - Chair 2000-20012000-2004 Graduate Studies Committee (Microbiology/Immunology)2001 Pulmonary Faculty Search Committee (Internal Medicine Dept)2002-2003 Curriculum Committee (Microbiology/Immunology)2002 Rackham Graduate School Distinguished Dissertation Award Committee2002 Immunology Faculty Search Committee (Microbiology & Immunology

Dept)2003 Microbiology Faculty Search Committee (Dental School)2003 University Committee on the Use and Care of Animals (UCUCA)2004 Graduate Studies and Admissions (Immunology)2005, 2010 Immunology Faculty Search Committee (Microbiology & Immunology

Department)2004-2008 The Committee for Science and Technology Recruiting to Improve

Excellence and Diversity (STRIDE)2008-2009 Microbial Ecology Faculty Search Committee, Department of

Microbiology & Immunology2007-2008 Medical School Dean's Faculty Compensation Committee2004-current Interdepartmental Undergraduate Microbiology Concentration Steering

Committee (Chair, 2008-current)2005-current Undergraduate Advisor, Microbiology Concentration, College of LS&A2012-current Co-Director, Multidisciplinary Training Program in Lung Disease

(Division of Pulmonary and Critical Care Medicine) 2008-current Microbial Ecology University Cluster Hire, Steering Committee2009-current UM Med School-China (Peking University) Joint Institute Lung Group

Visiting Professorships, Seminars, and Extramural Invited Presentations

International


6/1998 “The Role of TNF, Chemokines, and Microbial Virulence Factors in Th1/Th2 Immunity during Pulmonary Infection,” Department of Microbiology and Infectious Diseases, the University of Calgary, Canada

4/1999 “Cells and Cytokines in Pulmonary Cryptococcosis,” VII International Meeting on Paracoccidiomycosis, Sao Palo, Brazil

9/1999 “Cytokines and Leukocyte Recruitment into the Lungs during Cryptococcosis,” Fourth International Conference on Cryptococcus and Cryptococcosis, London, United Kingdom

6/2000 “Cryptococcosis: Knock-out to Knock-out, Mice to Yeast,” International Society for Human and Animal Mycology (ISHAM) Meeting, Buenos Aires, Argentina

9/2005 "The Microflora Hypothesis of Allergic Disease," British Association for the Advancement of Science, Dublin, Ireland

5/2006 "The Response to Fungal Exposure in the Respiratory Tract: Inflammation, Tolerance or Symbiosis?” McGill University, Montreal, Canada

10/2006 “Disruption of the Normal Flora: a Predisposing Factor for the Development of Asthma,” Infectious Diseases Society of America (IDSA) meting, Toronto, Canada

11/2007 "Probiotica," Uitgeverij Thoeris workshop, Amsterdam, Natherlands9/2012 "The consequences of microbiome and pathogen dynamics for chronic

lung diseases," European Respiratory Society, Vienna, Austria

National1/1990 "Cell-Mediated Immunity in the Lungs during Opportunistic

Infections", Department of Microbiology, University of Oklahoma Heath Sciences Center, Oklahoma City, OK

1/1992 “Protective and Non-Protective T Cell Mediated Responses during a Pulmonary Cryptococcus Neoformans Infection,” Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, the University of Michigan, Ann Arbor, MI

6/1993 “Host Defenses during a Cryptococcus Infection: Michigan Update”, Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX

11/1995 “The Role of TNF and MCP-1 in C. neoformans Pneumonia,” Upjohn/University of Michigan Symposium on the Use of Animals in Biological Research involving Adhesion Molecules and Cytokines, the University of Michigan, Ann Arbor, MI

5/1996 “Host Defense in Fungal Pneumonia,” American Thoracic Society Meeting, New Orleans, LA

6/1996 “Adhesion Molecules and Cytokines”, Upjohn/University of Michigan Symposium on the Use of Animals in Biological Research Involving Adhesion Molecules and Cytokines


5/1997 “Experimental Approaches to Pulmonary Host Defense”, ALA/ATS International Conference, San Francisco, CA

6/1997 “Immunity in Pulmonary Cryptococcosis”, Department of Pathology, University of New Mexico Medical School, Albuquerque, NM

8/1997 “Chemokines”, National Institute of Allergy and Infectious Diseases Workshop: ‘Immunology in Medical Mycology: Host Defense,’ Lake Tahoe, CA

6/1998 “Pulmonary Cryptococcosis: TNF, Chemokines, and Microbial Virulence Factors in Th1/Th2 Immunity,” Department of Pathology, University of New Mexico Medical School, Albuquerque, NM.

4/1999 “The Role of Chemokine Receptors in Leukocyte Recruitment and Th1/Th2 Immunity during C. neoformans Infection,” Department of Microbiology, Duke University, Durham, NC

6/1999 “Modulation of Innate and Acquired Immunity by Fungal Virulence Factors,” American Society for Microbiology Meeting, Chicago, IL

10/1999 “Leukocyte Migration in Cryptococcus Infections,” Lovelace Respiratory Research Institute Symposium on Respiratory Immunology, Santa Fe, NM

1/2000 “Role of Innate Immunity, Host Genetics, and Microbial Factors in Modulation of Pulmonary Immunity,” University of Texas Health Science Center at San Antonio, San Antonio, TX

2/2000 “Role of Innate Defenses in Modulation of Cell-Mediated Immunity to C. neoformans,” Louisiana State University Medical School, New Orleans, LA

4/2000 “Host-Microbe Interactions in the Development of Immunity to C. neoformans,” Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD

11/2000 “Microbial-Host ‘Cross Talk’ as a Mechanism for Chronic Infection,” University of Pittsburgh School of Medicine, Pittsburg, PA

7/2001 “Role of Melanin in Evasion of Host Defenses by Cryptococcus neoformans,” Burroughs Welcome Fund New Investigators Award Meeting, San Diego, CA

10/2001 “The Dynamics of Host and Pathogen Responses to Pulmonary Cryptococcus neoformans Infection,” Wayne State University Medical School, Detroit, MI

3/2002 “Immunity to Fungi: The Battle between Host and Parasite,” ASM Conference on Immunity to Bacterial, Viral and Protozoal Pathogens, Savannah, GA

4/2002 “The Dynamics of Host-Pathogen Interactions during Fungal Infection and Immunity,” Seattle Biomedical Research Institute, University of Washington, Seatttle, WA

5/2002. “Role of Innate Immunity and Fungal Virulence Factors in the Development of Adaptive Immunity,” American Society for Microbiology Meeting, Salt Lake City, UT

5/2002 “Fungal Pathogenesis and Immunity,” National Cancer Institute, Frederick, MD


6/2002 “T cell Immunity to Cryptococcus neoformans,” FASEB Summer Research Conference on Lymphocytes and Antibodies, Snowmass, CO

6/2002 “Insights into the Microbiology and Immunology Underlying Chronic Fungal Infections,” University of South Florida, Tampa, FL

1/2003 "Mechanisms of Immune Deviation during Chronic Fungal Infection,” University of North Carolina, Chapel Hill, NC

1/2003 “Role of Virulence Factors in the Pathogenesis of Cryptococcus neoformans,” Duke University, Durham, NC

1/2003 “(Dys)regulation of Immune Responses during Fungal Infection,” Penn State University, University Park, PA

4/2003 "Mechanisms of Immunoregulation during Fungal Infection: Clearance, Chronicity, or Hypersensitivity,” Medical College of Ohio, Toledo, OH

5/2003 “Update on Pulmonary Host Defense,” American Thoracic Society Meeting, Seattle, WA

8/2003 “Host-Fungus Interactions in Cryptococcus Pathogenesis”, Woods Hole Molecular Mycology Course, MA,

10/2003 “Regulation of Immunity to Fungi by Host and Microbial Factors,” University of Oklahoma, OK

11/2003 “Fungal Pathogenesis: Determinants of Clearance vs. Persistance vs. Hypersensitivity,” University of Nevada, NV

11/2003 “The Role of Fungal and Bacterial Microflora in Modulating Pulmonary Immunity to Fungi,” Dartmouth College, NH

12/2003 “Allergies, Antibiotics and the Fungal Connection,” Eastern Michigan University, MI

1/2004 “Chronic Infections and Allergies: The Connection between Antibiotics, Immunoregulation, Fungal Oxylipins and Gastrointestinal Microflora,” St. Louis University, MO

3/2004 “Polymicrobial Interactions and Host-Microbe Dynamics in the Regulation of Pulmonary Immunity,” Harvard University, MA

3/2004 “Recipe for Airway Allergies: Immature Dendritic Cells, Fungal Oxylipins and Antibiotics,” Columbia University, NY

3/2004 “Mechanisms Underlying Chronic Fungal Infections,” Keystone Symposium, CO

5/2004 “Pulmonary Immunity to Fungi,” MBI Workshop on Immunology Models: Cell Signaling and Immune Dynamics, Ohio State University, Columbus, OH

5/2004 “Fungal-Microflora Interactions in the Regulation of Adaptive Immunity to Fungi in the Airways,” American Society for Microbiology Meeting, New Orleans, LA

5/2004 “Fungal Persistence: Immunological Dynamics of the Host-Pathogen Interaction,” American Society for Microbiology Meeting, New Orleas, LA

8/2004 “Role of the Fungal Microbiota in Regulating Immune Responses in the Airways,” FASEB Summer Research Conference on Microbial Pathogenesis: Mechanisms of Infectious Disease, Snowmass, CO


11/2004 "Innate Immunity in Control of the Microbiota," Department of Defense Workshop on the Potential Role of Innate Immunity in Biodefense Strategies, Washington, DC

3/2004 "Regulation of Pulmonary Th2 Responses by the Gastrointestinal Microbiota," University of Texas Southwestern Medical School, Dallas, TX

3/2004 "Adaptive Immune Responses to Fungi," University of Texas Southwestern Medical School, Dallas, TX

6/2005 "The Dynamics of Cell-Mediated Immunity to Cryptococcus neoformans," Sixth International Conference on Cryptococcus and Cryptococcosis, Boston, MA

11/2005 "Development and Regulation of Pulmonary Immune Responses to Fungi,” Autumn Immunology Conference, Chicago, IL

4/2006 "Regulation of Anti-fungal Immunity,” University of Nevada-Reno, Reno, NV

9/2006 “Role of the Endogenous Microbiota in Host Immunity to Fungal Exposure,” the University of Illinois, Chicago, IL

12/2006 “Role of the Microbiota in Regulating Pulmonary Immune Responses,” ULAM, University of Michigan, Ann Arbor, MI

12/2006 “Role of the Microbiota in Pulmonary Immunity to Fungi” Loyola University Medical Center, Chicago, IL

2/2007 “Role of the Endogenous Microbiota in Modulating Pulmonary Fungal Pathogenesis and the Host Response,” Mid-Atlantic Microbial Pathogenesis Meeting, Wintergreen, VA

3/2007 “Regulation of Mucosal Immunity by the Endogenous Microbiota,” University of Wisconsin School of Medicine, Madison, WI

4/2007 "Role of the Endogenous Microbiota in Modulating Host Immunity and Health," National Human Genome Research Institute (NHGRI) workshop on the microbiome, Bethesda, MD

6/2007 "Probiotics," Dannon Institute of Nutrition, Baltimore, MD7/2007 "Role of the Endogenous Microbiota in Modulating Host Pulmonary

Immunity," National Heart, Lung and Blood Institute (NHLBI), Bethesda, MD

10/2007 "Pre-and Probiotic Strategies to Improve Immune Health," Dannisco Probiotics Symposium, Madison, WI

11/2007 "Workshop: Ethical, legal, and social implications (ELSI) of the field of metagenomics and the Human Microbiome Project" Center for Genetic Research Ethics and Law, Case Western Reserve University, Cleveland, OH

12/2007 "Animal Models of Immune System Development and Modulation Throughout Lifespan," Prebiotics and Probiotics Workshop, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

3/2008 "The Role of Probiotics, Candida albicans and the Indigenous Microbiota in Immune System Function," ASM Meeting on Candida and Candidiasis, Jersey City, NJ


4/2008 "Role of the Indigenous Microbiota in Immune Regulation,"Cleveland Clinic, Cleveland, OH

4/2008 "The Health Benefits of Probiotics and Prebiotics," Michigan Dietetic Association, Sterling Hts, MI

4/2008 "'We are only 10% human' - The reliance of the immune system on the indigenous microbiota," 20th Annual Buffalo Conference on Microbial Pathogenesis, Buffalo, NY

5/2008 "Regulation of Immunity by the Indigenous Microbiota'" Microbiology Dept, Wake Forest University, Winston-Salem, NC

6/2008 "Candida albicans as a Commensal: Effects on the Bacterial Microbiota and Immune System," 2008 ASM General Meeting - Division F Lecture

9/2008 "The Microbiota and Immune Regulation during Chronic Pulmonary Aspergillus Exposure," Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT

10/2008 "Probiotics and Human Health," Michigan Branch of the ASM, Eastern Michigan University, Ypsilanti, MI

1/2009 "Fungi, bacterial microbiota and the regulation of mucosal immunity," Department of Pathology and Laboratory Medicine, The Children's Hospital of Pennsylvania/University of Pennsylvania

2/2009 "Regulation of Mucosal Immunity by the Indigenous Microbiota," Division of Gastroenterology, University of Chicago, Chicago, IL

9/2009 “Modulation of Mucosal Immunity by the Microbiome”, Immunopathology of Pulmonary Disease Seminars, Department of Pathology, University of Michigan

12/2009 "Insights into the interplay between the bacterial microbiota, Candida albicans and host mucosal Immunity," Minnesota Craniofacial Research Training Program, University of Minnesota, Minneapolis, MN

1/2010 "Mucosal Immunity and Bacterial-Yeast Interactions in the Microbiota", Microbiology Department, Michigan State University, East Lansing, MI

1/2010 “Setting the stage for a systems biology approach to mucosal biology, immunity, and microbiology”, Center for Computational Medicince & Biology, University of Michigan

5/2010 “Modulation of Mucosal Immunity by the Bacterial and Fungal Microbiota”, ASM General Meeting, San Diego, CA

10/2010 “Probiotics and the Role of the Microbiome in Regulating Mucosal Immunity outside the GI tract”, Keynote Speaker, Proctor & Gamble, Biofusion International Conference, Cincinnati, OH

10/2010 “Regulation of Mucosal Immunity by the Fungal Microbiota”, ASM Benefical Microbes Meeting, Miami, FL

11/2010 “Regulation of Mucosal Immunity by the Indigenous Microbiota”, NIEHS Workshop on the Microbiome and the Environment

1/2011 “Probiotics in Health and Disease”, Washtenaw District Dental Society, Ann Arbor, MI


4/2011 “Microbiome and Respiratory Disease”, National Academy of Sciences Workshop: Interplay of Microbiome, Environmental Stressors, and Human Health, Washington, DC

5/2011 “The Science Behind Probiotics”, Consumer Home Products Association Science and Regulatory Conference, Washington, DC

5/2011 “Role of Fungi in Asthma”, ATS International Meeting, Denver, CO5/2011 “The Gut Microbiota and Extra-Intestinal Disease”, ATS International

Meeting, Denver, CO6/2011 "The Lungs, the Gut and the Microbiome: A Love Story," Department

of Internal Medicine, University of Wisconsin, Madison, WI10/2011 "Microbiome-Host Interactions in Modulating Local and Distal

Mucosal Responses," Department of Embryology, Carnegie Institution for Science, Baltimore, MD (CIS Sympoisum: Microbes- Invisible Partners in Health)

11/2011 "Dissecting Bacterial-Yeast-Host Mucosal Symbiosis," Microbiology Department, Ohio State University, Columbus, OH

12/2011 "The NHLBI, the Gut and the Microbiome," Plenary Lecture, Human Lung Microbiome Workshop and Advisory Panel, National Heart, Lung & Blood Institute, NIH, Bethesda, MD

3/2012 "Innate and Adaptive Immunity in the Gastrointestinal Tract," American Academy of Allergy, Asthma and Immunology Annual Program Meeting, Orlando, FL

3/2012 "Microbiome Disturbances and Its Affect on Mucosal Host Responses," Microbiology Program, Iowa State University, Ames IA

Bibliography

Completed Publications in Scientific Journals: Peer-Reviewed1. Gaffney EV, Tsai S, Lingenfelter SE, Dell'Aquila ML, Huffnagle GB. Biological

response modifiers released by a mezerein-treated human monocytic leukemic cell line. J Biol Resp Med 1985; 4:396-407.

2. Gaffney EV, Dell'Aquila ML, Lingenfelter SE, Huffnagle GB, Wiest DL. Characterization of a colony-stimulating factor produced by the human monocytic leukemic cell line, THP-1. J Leuk Biol 1986; 39:409-421.

3 Huffnagle GB, Ratcliffe MJH, Humphries EH. Bu-2, a novel avian cell surface antigen on B cells and a population of non-lymphoid cells, is expressed homogeneously in germinal centers. Hybridoma 1989; 8(6):589-604.

4. Huffnagle GB, Yates JL, Lipscomb MF. T cell-mediated immunity in the lung: a Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect Immun 1991; 59 (4):1423-1432.

5. Huffnagle GB, Yates JL, Lipscomb MF. Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells. J Exp Med 1991; 173:793-800.

6. Huffnagle GB, Lipscomb MF. Animal model of human disease: pulmonary cryptococcosis. Am J Path 1992; 141(6):1517-1520.


7. Huffnagle GB, Lipscomb MF, Lovchik JA, Hoag KA, Street NE. The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leuk Biol 1994; 55:35-42.

8. Curtis JL, Huffnagle GB, Chen GH, Warnock ML, Gyetko MR, McDonald RA, Scott PJ, Toews GB. Experimental murine pulmonary cryptococcosis: differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of C. neoformans. Lab Invest 1994; 71(1): 113-126.

9. Smith RE, Strieter RM, Phan SH, Lukacs NW, Huffnagle GB, Wilke CA, Burdick MD, Lincoln P, Evanoff H, Kunkel SL. Production and function of murine macrophage inflammatory protein-1 in bleomycin-induced lung injury. J Immunol 1994; 153: 4704-4712.

10. Huffnagle GB, Chen GH, Curtis JL, McDonald RA, Strieter RM, Toews GB. Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans. J Immunol 1995; 155:3507-3516.

11. Hoag KE, Street NE, Huffnagle GB, Lipscomb MF. Early cytokine production in pulmonary C. neoformans and infections distinguishes susceptible and resistant mice. Am J Resp Cell Mol Biol 1995; 13(4): 487-495.

12. Huffnagle GB, Strieter RM, Standiford TJ, McDonald RA, Burdick MD, Kunkel SL, Toews GB. The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection. J Immunol 1995; 155:4790-4797.

13. McCoy RD, Davidson BL, Roessler BJ, Huffnagle GB, Janich SL, Laing TJ, Simon RH. Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. Human Gene Therapy 1995; 6:1653-1660.

14. Gyetko MR, Chen GH, McDonald RA, Goodman RE, Huffnagle GB, Wilkinson CC, Fuller JA, Toews GB. Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. J Clin Invest 1996; 97:1818-1826.

15. McCoy RD, Davidson BL, Roessler BJ, Huffnagle GB, Simon RH. Expression of human interleukin receptor-1 antagonist in mouse lungs using a recombinant adenovirus: effects on vector induced inflammation. Gene Therapy 1996; 2:437-442.

16. Strieter RM, Standiford TJ, Huffnagle GB, Colletti LM, Lukacs NW, Kunkel SL. The good, the bad, and the ugly: the role of chemokines in models of human disease. J Immunol 1996; 156:3583-3586.

17. Huffnagle GB. The role of cytokines in T cell immunity to a pulmonary C. neoformans infection. Biol Signals 1996; 5:215-222.

18. Huffnagle GB, Toews GB, Burdick MD, McAllister KS, McDonald RA, Boyd MB, Kunkel SL, Strieter RM. Afferent phase production of TNF is required for the development of protective T cell immunity to Cryptococcus neoformans. J Immunol 1996; 157:4529-4536.

19. Brieland J, McClain M, Heath L, Chrisp C, Huffnagle G, LeGendre M, Hurley M, Fantone J, Engleberg C. Coinoculation with Hartmannella vermiformis enhances replicative Legionella pneumophila lung infection in a murine model of Legionnaires’ disease. Infect Immun 1996; 64:2449-2456.

20. Brieland JK, Heath LA, Huffnagle GB, Remick DG, McClain MS, Hurley MC, Kunkel RK, Fantone JC, Engleberg C. Humoral immunity and regulation of intrapulmonary


growth of Legionella pneumophila in the immunocompetent host. J Immunol 1996; 157:5002-5008.

21. Heath L, Chrisp C, Huffnagle G, LeGendre M, Osawa Y, Hurley M, Engleberg C, Fantone J, Brieland J. Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 1996; 64:5151-5160.

22. Standiford TJ, Huffnagle GB. The role of cytokines in pneumonia. J Investig Med 1997; 45:335-345.

23. Huffnagle GB, Strieter RM, McDonald RA, NcNeil LK, Burdick MD, Kunkel SL, Toews GB. Macrophage inflammatory protein-1 (MIP-1) is required for a protective pulmonary inflammatory response to Cryptococcus neoformans. J Immunol 1997; 159:318-327.

24. Hogaboam CM, Chensue SW, Steinhauser ML, Huffnagle GB, Lukacs NW, Strieter RM, Kunkel SL. Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. J Immunol 1997; 159:5585-5593.

25. Huffnagle GB, Boyd MB, Street NE, Lipscomb MF. IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically “susceptible” mice (C57BL/6). J Immunol 1998; 160:2393-2400.

26. Laichalk LL, Bucknell KA, Huffnagle GB, Wilkowski JM, Moore TA, Romanelli RJ, Standiford TJ. The intrapulmonary delivery of tumor necrosis factor agonist peptide augments host defense in murine gram negative bacterial pneumonia. Infect Immun 1998; 66:2822-2826.

27. Gharaee-Kermani M, McGarry B, Lukacs N, Huffnagle G, Egan RW, Phan SH. The role of IL-5 in bleomycin-induced pulmonary fibrosis. J Leukoc Biol 1998; 64(5):657-666.

28. Huffnagle GB, Lipscomb MF. Cells and cytokines in pulmonary cryptococcosis. Res Immunol 1998; 149:387-396.

29. Huffnagle GB, McNeil LK. Dissemination of C. neoformans to the central nervous system: role of chemokines, Th1 immunity, and leukocyte recruitment. J Neurovirol 1999; 5:76-81.

30. Coffey MJ, Phare SM, Peters-Golden M, Huffnagle GB. Regulation of 5-lipoxygenase metabolism in monnuclear phagocytes by CD4 T lymphocytes. Exp Lung Res 1999; 25: 617-629.

31. Huffnagle GB, McNeil LK, McDonald RA, Murphy JW, Toews GB, Maeda N, Kuziel WA. Cutting edge: role of CCR5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol 1999; 163:4642-4646.

32. Lovchik JA, Wilder JA, Huffnagle GB, Riblet R, Lyons CR, Lipscomb MF. Development of a protective Th1 immune response in a murine cryptococcal infection is influenced by genes linked to the Igh complex. J Immunol 1999; 163:3907-3913.

33. Traynor TR, Kuziel WA, Toews GB, Huffnagle GB. CCR2 expression determines T1 vs. T2 polarization during pulmonary Cryptococcus neoformans infection. J Immunol 2000; 164(4):2021-2027.

34. Huffnagle GB, Traynor TR, McDonald RA, Olszewski MA, Lindell DM, Toews GB. Leukocyte recruitment during pulmonary C. neoformans infection. Immunopharmacology 2000; 48(3):231-236.


35. Brieland JK, Engleberg NC, Huffnagle GB, Remick DG, Fantone JC. Host pathogen interactions in Legionnaires' disease: lessons learned from a murine animal model. Immunopharmacology 2000; 48(3):249-52.

36. Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle GB, Sher A. CCR5 provides a signal for microbial induced production of IL-12 by CD8+ dendritic cells. Nature Immunol 2000; 1:83-87.

37. Olszewski MA, Huffnagle GB, McDonald RA, Lindell DM, Cook DN, Toews GB. The role of MIP-1/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection. J Immunol 2000; 165(11):6429-36.

38. Fife BT, Huffnagle GB, Kuziel WA, Karpus WJ. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med 2000; 192(6):899-906.

39. Noverr MC, Phare SM, Toews GB, Coffey MJ, Huffnagle GB. Production of immunomodulatory prostaglandins by the pathogenic yeast Cryptococcus neoformans and Candida albicans. Infect Immun 2001; 69(5):2957-63.

40. Olszewski MA, Huffnagle GB, McDonald RA, Traynor, TT, Cook DN, Toews GB. MIP-1/CCL3 regulatory effects on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines. Infect Immun 2001; 69(10): 6256-6263.

41. Lindell DM, Standiford TJ, Leshen Z, Mancuso P, Huffnagle GB. MIP-1/CCL3 is required for clearance of Klebsiella pneumoniae from the lung. Infect Immun 2001; 69(10): 6364-6369.

42. Traynor TR, Herring AC, Dorf ME, Kuziel WA, Toews GB, Huffnagle GB. Differential roles of CCL2/MCP-1 and CCR2 in the development of T1 immunity. J Immunol 2002; 168(9):4659-66.

43. Noverr MC, Toews GB, Huffnagle GB. Production of prostaglandins and leukotrienes by pathogenic fungi. Infect Immun 2002; 70(1):400-402.

44. Herring AC, Lee J, Toews GB, Huffnagle GB. Induction of early IL-12 and IFNrequires TNF for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection. Infect Immun 2002; 70(6):2959-64.

45. Mancuso P, Gotchalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J Immunol 2002; 168(8):4018-4024.

46. Noverr MC, Cox GM, Perfect JR, Huffnagle GB. The role of cryptococcal phospholipase B (CnPLB1) in the pathogenesis of pulmonary Cryptococcus neoformans infection. Infect Immun 2003; 71(3):1538-47.

47. Bauman SK, Huffnagle GB, Murphy JW. Effects of tumor necrosis factor alpha on dendritic cell accumulation in lymph nodes draining the immunization site and the impact on the anticryptococcal cell-mediated immune response. Infect Immun 2003; 71(1):68-74.

48. Moore SI, Huffnagle GB, Chen GH, White E, Mancuso P. Leptin modulates neutrophil phagocytosis of K. pneumoniae. Infect Immun 2003; 71(7):4182-5.

49. Noverr MC, Williamson PR, Fajardo RS, Huffnagle GB. CNLAC1 is required for extra-pulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence. Infect Immun 2004; 72(3):1693-9.


50. Olszewski MA, Noverr MC, Chen GH, Toews GB, Cox GM, Perfect JR, Huffnagle GB. Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing CNS invasion. Am J Pathol 2004; 164(5):1761-71.

51. Noverr MC, Noggle RM, Toews GB, Huffnagle GB. Role of antibiotics and fungal microbiota in driving pulmonary allergic responses. Infect Immun 2004; 72(9):4996-5003.

52. Noverr MC, Huffnagle GB. Regulation of Candida albicans morphogenesis by fatty acid metabolites Infect Immun 2004; 72(11):6206-10.

53. Speyer CL, Gao H, Rancilio NJ, Neff TA, Huffnagle GB, Sarma JV, Ward PA. Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol 2004; 165(6):2187-96.

54. Herring AC, Falkowski NR, Chen GH, McDonald RA, Toews GB, Huffnagle GB. Transient neutralization of TNF can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells. Infect Immun 2005; 73(1):39-49.

55. Noverr MC, Falkowski NR, McDonald RA, McKenzie AN, Huffnagle GB. The development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of genetics, antigen and IL-13. Infect Immun 2005; 73(1):30-8.

56. Hernandez YS, Arora S, McDonald RA, Toews GB, Huffnagle GB. Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J Immunol 2005; 174(2):1027-36.

57. Chen GH, McDonald RA, Wells JC, Huffnagle GB, Toews GB. Interferon gamma receptor is required for the pulmonary inflammatory response to Cryptococcus neoformans. Infect Immun 2005; 73(3):1788-96.

58. Arora S, Hernandez YS, Erb-Downward JR, Toews GB, Huffnagle GB. Role of IFN-in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 2005; 174(10):6346-56.

59. Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB. Generation of anti-fungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection. J Immunol 2005; 174(12):7920-8.

60. Schaller MA, Lundy SK, Huffnagle GB, Lukacs NW. CD8+ T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivity. Eur J Immunol 2005; 35(7):2061-70.

61. Erb-Downward JR, Huffnagle GB. Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase. Eukaryot Cell. 2007 Feb;6(2):346-50. PMCID 1797952

62. Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB. Distinct compartmentalization of CD4+ T cell effector function versus proliferative capacity during pulmonary cryptococcosis. Am J Pathol 2006; 168(3):847-55.

63. Amlie-Lefond C, Paz DA, Connelly MP, Huffnagle GB, Dunn KS, Whelan KS, Whelan HT. Innate immunity for biodefense: a strategy whose time has come. J Allergy Clin Immunol 2005; 116(6):1334-42.

64. Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden M. Leptin restores host defense impairments following acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med 2006; 173(2):212-8.


65. Lindell DM, Ballinger MN, McDonald RA, Toews GB, Huffnagle GB. Immunologic homeostasis during infection: co-existence of strong pulmonary cell-mediated immunity to secondary Cryptococcus neoformans infection while the primary infection still persists at low levels in the lungs. J Immunol 2006; 177(7):4652-61.

66. Lindell DM, Ballinger MN, McDonald RA, Toews GB, Huffnagle GB. Diversity of the T cell Response to Pulmonary Cryptococcus neoformans Infection. Infect Immun 2006; 74(8):4538-48.

67. Arora S, McDonald RA, Toews GB, Huffnagle GB. Effect of a CD4-depleting antibody on the development of C. neoformans-induced allergic bronchopulmonary mycosis in mice. Infect Immun 2006; 74(7):4339-48.

68. Heffernan BJ, Thomason B, Herring-Palmer A, Shaughnessy L, McDonald R, Fisher N, Huffnagle GB, Hanna P. Bacillus anthracis phospholipases C facilitate macrophage-associated growth and contribute to virulence in a murine model of inhalation anthrax. Infect Immun 2006; 74(7):3756-64.

69. Chen GH, Olszewski MA, McDonald RA, Wells JC, Paine R 3rd, Huffnagle GB, Toews GB. Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis. Am J Pathol 2007; 170(3):1028-40.

70. Milam JD, Herring AC, Pandrangi R, McDonald R, Huffnagle GB, Toews GB. Modulation of the pulmonary T2 response to Cryptococcus neoformans by intratracheal delivery of a TNFα-expressing adenoviral vector. Infect Immun 2007;75(10):4951-8.

71. Rodriguez TE, Falkowski NR, Harkema JR, Huffnagle GB. Analysis of the role of neutrophils in preventing and resolving acute fungal sinusitis. Infect Immun 2007;75(12):5663-8

72. Berndt BE, Zang M, Chen GH, Huffnagle GB, Kao JY. The role of dendritic cells in the development of acute dextran sulfate sodium colitis. J Immunol 2007;179(9):6255-62.

73. Olszewski MA, Falkowski NR, Surana R, Sonstein J, Hartman A, Moore BB, Huffnagle GB, Toews GB. Effect of Laparotomy on Clearance and Cytokine Induction in Staphylococcus aureus-infected Lungs. Am J Respir Crit Care Med. 2007;176(9):921-9

74. Erb-Downward JR, Noggle RM, Williamson PR, Huffnagle GB. The role of laccase in prostaglandin production by Cryptococcus neoformans. Mol Microbiol 2008; 68(6):1428-37.

75. Chen GH, McNamara D, Hernandez Y, McDonald RA, Toews GB, Huffnagle GB, Olszewski MA. Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model. Infect Immun 2008; 76(6):2379-91. PMCID: PMC2423067

76. Osterholzer JJ, Polac T, Ames T, Chen GH, McDonald R, Huffnagle GB, Curtis JL, Toews GB. CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans. J Immunol 2008; 181(1):610-20. PMCID: PMC2735104

77. Lau HY, Huffnagle GB, Moore TA. Host and microbiota factors that control Klebsiella pneumoniae mucosal colonization in mice. Microbes Infect 2008; 10(12-13):1283-90. PMCID: PMC2633640

78. O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL. Loss of Na(+) channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci. 2008;40(2):143-55. PMCID: PMC2670461


79. Osterholzer JJ, Surana R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL, Huffnagle GB, Toews GB, Olszewski MA. Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung. Am J Pathol 2009; 174(3):932-43. PMCID: PMC2665753

80. Osterholzer JJ, Milam JE, Chen GH, Toews GB, Huffnagle GB, Olszewski MA. Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans. Infect Immun 2009;77(9):3749-58. PMCID: in progress

81. Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Huffnagle GB, Olszewski, MA. Development of robust Th1 immunity is insufficient for full protection against highly virulent C. neoformans H99 in mouse model of pulmonary infection. Am J Pathol 2009;175(6):2489-500

82. Jain A, Zhang Y, Fields BW, McNamara DA, Choe, MY, Chen GH, Erb-Downward JR, Osterholzer JJ, Toews GB, Huffnagle GB, and Olszewski MA. Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary C. neoformans infection. Infect Immun 2009; ;77(12):5389-99.

83. Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB. Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes. J Immunol 2009;183(12):8044-53.

84. Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski MA. Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99. Am J Pathol 2009 Dec;175(6):2489-500.

85. Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB, Huffnagle GB, and Olszewski MA. CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death. Am J Pathol 2010;176(1):218-26.

86. Shetron-Rama LM, Herring-Palmer AC, Huffnagle GB, Hanna P. Transport of Bacillus anthracis from the lungs to the draining lymph nodes is a rapid process facilitated by CD11c+ cells. Microb Pathog. 2010; 49(1-2):38-46.

87. Reid G, Gaudier E, Guarner F, Huffnagle GB, Macklaim J, Munoz AM, Martini M, Ringel-Kulka T, Sartor B, Unal, RR, Verbeke K, Walter J. Responders and non-responders to probiotic interventions: how can we improve the odds? Gut Microbes 2010; 1(3):200-4

88. Chen GH, Osterholzer JJ, Choe MY, McDonald RA, Olszewski MA, Huffnagle GB, Toews GB. Dual Roles of CD40 on Microbial Containment and the Development of Immunopathology in Response to Persistent Fungal Infection in the Lung. Am J Pathol. 2010; 177(5):2459-71.

89. Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA. TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs. Am J Pathol. 2010 177(2):754-65

90. Osterholzer JJ, Chen GH, Olszewski MA, Zhang YM, Curtis JL, Huffnagle GB, Toews GB. Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection. Am J Pathol. 2011;178(1):198-211.


91. Murdock BJ, Shreiner AB, McDonald RA, Osterholzer JJ, White ES, Toews GB, Huffnagle GB. Co-evolution of TH1, TH2 and TH17 Responses During Repeated Pulmonary Exposure to Aspergillus fumigatus Conidia. Infect Immun. 2011 79(1):125-35.

92. Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Young VB, Toews GB, Curtis JL, Martinez FJ, Huffnagle GB. Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD. PLoS One 2011; 6(2):e16384.

93. Arora S, Olszewski MA, Tsang TM, McDonald RA, Toews GB, Huffnagle GB. Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans. Infect Immun. 2011;79(5):1915-26.

94. Reeves AE, Theriot CM, Bergin IL, Huffnagle GB, Schloss PD, Young VB. The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection. Gut Microbes. 2011;2(3):145-58.

95. Mason KL, Erb Downward JR, Falkowski NR, Young VB, Kao JY, Huffnagle GB. Interplay between the gastric bacterial microbiota and Candida albicans during post-antibiotic recolonization and gastritis. Infect Immun. 2012; 80(1):150-8.

96. Shreiner AB, Murdock BJ, Sadighi Akha AA, Falkowski NR, Christensen PJ, White ES, Hogaboam CM, Huffnagle GB. Repeated exposure to Aspergillus fumigatus conidia results in CD4+ T cell-dependent and-independent pulmonary arterial remodeling in a mixed Th1/Th2/Th17 microenvironment that requires IL-4 and IL-10. Infect Immun 2012; 80(1):388-97.

97. Gillilland III MG, Erb-Downward JR, Shen MC, Bassis CM, Toews GB, Young VB, Huffnagle GB. Ecological succession of bacterial communities during conventionalization of germ-free mice. Applied Environ Micro. 2012; 78(7):2359-66.

98. Murdock BJ, Falkowski NR, Sadighi Akha AA, McDonald RA, White ES, Toews GB, Huffnagle GB. IL-17 drives pulmonary eosinophilia following repeated Aspergillus fumigatus conidia exposure. Infect Immun. 2012 Apr;80(4):1424-36.

99. Mason KL, Erb Downward JR, Mason KD, Falkowski NR, Eaton KA, Kao JY, Young VB, Huffnagle GB. Candida albicans and bacterial microbiota interactions in the cecum during re-colonization following broad spectrum antibiotic therapy. Infect Immun. 2012 80(10):3371-80

100. Sun Y, Chen C-C, Zhang M, Zhang J, Gillilland M, Huffnagle GB, Owyang C, Gumuico DL, Hong S-C, Kao JY. Stress-induced NLRP6 inflammasome inhibition causes intestinal dysbiosis and communicable enteritis. Gastroenterology. (in press 2013)

101. Berndt BE, Zhang M, Owyang SY, Cole TS, Wang T, Luther J, Veniaminova NA, Merchant JL, Chen C-C, Huffnagle GB, Kao JY. Butyrate’s immunoregulatory effect on stimulated dendritic cells and the involvement of IL-23/IL-10 axis. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1384-92

102. Miyasaka EA, Feng Y, Poroyko V, Falkowski NR, Erb-Downward JR, Gillilland M, Mason KL, Huffnagle GB, Teitelbaum DH. Total parenteral nutrition-associated lamina propria inflammation is mediated by a MyD88 dependent mechanism (submitted)

103. Vital M, Penton CR, Wang W, Young VB, Antonopoulos DA, Sogin MM, Morrison HG, Raffals L, Chang FB, Huffnagle GB, Schmidt TM, Cole JR, Tiedje JM. A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community. Microbiome (in press)


104. Sadighi Akha AA, Theriot CM, Erb-Downward JR, McDermott AJ, Falkowski NR, Tyra HM, Rutkowski DT, Young VB and Huffnagle GB. Acute infection of mice with Clostridium difficile leads to an innate immune response, eIF2α phosphorylation and pro-survival signaling. Immunology (in press)

105. Erb-Downward JR, Falkowski NR, Mason KL, Muraglia R and Huffnagle GB. Modulation of post-antibiotic bacterial community reassembly and host response by Candida albicans. (submitted)

Completed Publications in Scientific Journals: Non Peer-Reviewed 1. Lipscomb MF, Huffnagle GB, Lovchik J, Lyons CR, Pollard AM, Yates JL. The role of

T lymphocytes in pulmonary microbial defense mechanisms. Arch Path Lab Med 1993; 117:1225-1232.

2. Deepe GS, Romani L, Calich VLG, Huffnagle G, Arruda C, Molinari-Madlum EEIW, Perfect JR. Knockout mice as experimental models of virulence. Med Mycology 2000; 38 (Suppl 1):87-98.

3. Traynor TR, Huffnagle GB. Role of chemokines in fungal infections. Med Mycology 2001; 39:41-50.

4. Huffnagle GB, Herring AC, Traynor TR. Role of fungal virulence factors in evasion of host defenses. Annu Rev Biomed Sci 2001; 2:77-90.

5. Huffnagle GB. Investigating invasive aspergillosis. Am J Respir Crit Care Med 2002; 166(9):1159-60.

6. Huffnagle GB. Innate Immunity to fungi. EOS – J Immunol Immunopharmacol 2002; 2: 48-51.

7. Huffnagle GB, Deepe GS. Innate and adaptive determinants of host susceptibility to medically important fungi. Curr Opin Microbiol 2003; 6(4):344-50.

8. Noverr MC, Erb-Downward JR, Huffnagle GB. Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin Micro Rev 2003; 16(3):517-33.

9. Herring AC, Hernandez Y, Huffnagle GB, Toews GB. Role and development of Th1/Th2 immune responses in the lungs. Sem Resp Crit Care Med 2004; 25(1):3-10.

10. Hernandez Y, Herring AC, Huffnagle GB. Pulmonary defenses against fungi. Sem Resp Crit Care Med 2004; 25(1):63-71.

11. Arora S, Huffnagle GB. Immune regulation during allergic bronchopulmonary mycoses: lessons taught by two fungi. Immunol Res 2005; 33(1):53-68.

12. Noverr MC, Huffnagle GB. Does the microbiota regulate immune responses outside the gut? Trends Microbiol 2004; 12(12):562-8.

13. Noverr MC, Huffnagle GB. The "Microflora Hypothesis" of allergic diseases. Clin Exp Allergy Immunol 2005; 35(12):1511-20.

14. Erb-Downward J, Huffnagle GB. Role of oxylipins and other lipid mediators in fungal pathogenesis. Future Microbiol 2006; 1(2):219-227

15. Goldman DL, Huffnagle GB. Potential contribution of fungal infection and colonization to the development of allergy. Med Mycol 2009; 22:1-12.

16. Mason KL, Huffnagle, GB. Control of mucosal polymicrobial populations by innate immunity. Cell Microbiol 2009;11(9):1297-305.

17. Huffnagle GB. The Microbiota in Allergies/Asthma. PLoS Pathogens 2010; 6(5):e1000549


18. Olszewski MA, Zhang Y, Huffnagle GB. Mechanisms of cryptococcal virulence and persistence. Future Microbiol. 2010 Aug;5:1269-88.

19. Beck JM, Young VB, Huffnagle GB. The microbiome of the lung. Transl Res. 2012 (in press)

20. Erb-Downward JR, Huffnagle GB, Martinez FJ. The microbiota in respiratory disease. Am J Respir Crit Care Med. 2012 May 15;185(10):1037-8.

21. Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ. Significance of the microbiome in obstructive lung disease. Thorax. 2012 May;67(5):456-63.

22. Scales BS, Huffnagle GB. The Microbiome in Wound Repair and Fibrosis. J Pathol (submitted)

Chapters in Books1. Huffnagle GB, Strieter RM, Kunkel SL, Toews GB, Standiford T. The role of

chemokines in pneumonia. The Role of Chemokines in Disease, A Koch and RM Strieter, eds. R. G. Landes Co., Austin, TX; (1996).

2. Huffnagle GB, Toews GB. Mechanisms of macrophage recruitment to infected lungs. Lung Macrophages and Dendritic Cells, MF Lipscomb and S Russell, eds. Marcel Dekker Inc., NY; (1997).

3. Herring AC, Huffnagle GB. Innate immunity and fungal infections. Immunology of Infectious Diseases, SHE Kaufmann, A Sher, R Ahmed, eds. ASM Press, Wash DC (2001).

4. Lindell DM, Huffnagle GB. Pulmonary cell-mediated immunity to Cryptococcus neoformans. Fungal Immunology from an Organ Perspective, Fidel PL and Huffnagle GB, eds. Kluwer Academic/Plenum Publishers, NY (2005).

5. Rodriguez T, Huffnagle GB. Fungal sinusitis. Fungal Immunology from an Organ Perspective, Fidel PL and Huffnagle GB, eds. Kluwer Academic/Plenum Publishers, NY (2005).

6. Noverr MC, Lindell DM, Toews GB, Huffnagle GB. Fungal interactions with leukocytes. Molecular Principles of Fungal Pathogenesis, Heitman J, Edwards J, Filler S, Mitchell A, eds. ASM Press (2006).

7. Shreiner A, Huffnagle GB, Noverr MC. The “Microflora Hypothesis” of Allergic Disease. Microbiota and Immunology, Landes Bioscience, M. Noverr & G. Huffnagle, eds. (2008)

8. Mason KL, Huffnagle GB, Noverr MN, Kao JY. Gut Immunology. Microbiota and Immunology, Landes Bioscience, M. Noverr & G. Huffnagle, eds. (2008).

9. Williams K, Wormley F, Geunes-Boyer S, Wright JR, Huffnagle GB. Pulmonary innate and adaptive defenses against Cryptococcus in Cryptococcus: from human pathogen to model yeast, ASM Press, Heitman J, Kwon-Chung J, Perfect J, Casadevall A, Kozel TR, eds. (2010).

10. Gillilland MG, Young VB, Huffnagle GB. Gastrointestinal Microbial Ecology With Perspectives on Health and Disease, Physiology of the Gastrointestinal Tract, 5th edition. Johnson L, Ghishan F, Kaunitz J, Merchant J, Said H, Wood J, eds. (in press)

Book Reviews


1. Huffnagle GB. Review of Cryptococcus neoformans by Casadevall and Perfect (ASM Press.) Mycopathologia, 1999; 147:59-60.

Edited Books1. Fungal Immunology from an Organ Perspective, Fidel PL and Huffnagle GB, eds.

Kluwer Academic/Plenum Publishers, NY (2005).2. GI Microbiota and Regulation of the Immune System. Huffnagle GB and Noverr MC,

Landes Bioscience, Austin, TX (2008)

Authored Books1. The Probiotics Revolution, Huffnagle GB and Wernick S, Bantam (division of Random

House Publishers), NY (Hardcover, 2007) De probiotica-revolutie, Huffnagle GB and Wernick S, Thoeris uitgeverij,

Amsterdam, Netherlands (Hardcover, 2007) - Dutch translation The Probiotics Revolution, Huffnagle GB and Wernick S, Vermilion, NY

(Hardcover, 2007) - United Kingdom release The Probiotics Revolution (updated), Huffnagle GB and Wernick S, Bantam, NY

(Trade Paperback, 2008) The Probiotics Revolution, Huffnagle GB and Wernick S, Thinkingdom Media Group

LTD, China (Hardcover, 2008) - Chinese translation The Probiotics Revolution, Huffnagle GB and Wernick S, Matichon Publishing

House (Hardcover, 2010)- Thai translation


Documents

Galen B · Web viewThe Probiotics Revolution, Huffnagle GB and Wernick S, Thinkingdom Media Group LTD, China (Hardcover, 2008) - Chinese translation The Probiotics Revolution, Huffnagle