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8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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Qtktl Ily Hkfbvktbvy bg @kt|vkh k`d Fobeoeltoa Dv|cq k`d Dlzkvtel`t bg Amleoakh Fobhbcy( Qambbh bg Zmkvekal|toakh Qaol`alq(
Zlio`c \`owlvqoty Mlkhtm Qaol`al Al`tlv( Flono`c( Amo`k
Ckdbho`o|e -Cd/( k eleflv bg tml hk`tmk odl gkeohy( mkq
fll` |qld l}tl`qowlhy o` wkvob|q o`d|qtvokh k`d eldoakh
kzzhoaktob`q. Cd%amlhktld dlvowktowlq mkwl fll` sodlhy |qld
o` aho oakh zvkatoal kq k ab`tvkqt eldo|e gbv ekc`ltoa
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aho oakh tvokhq kq k tvlktel t gbv h|`c ak alv( qzlaoakhhy
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M|ek` l}zbq|vl tb Cd k`d otq dlvowktowlq oq qoc`oak`thy
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Vlal`thy( `lzmvbcl`oa qyqtleoa fvbqoq( k gktkh doqlkql( skq
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8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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Zvbebtld zvbd|atob` bg gvll vkdoakhq( o`ah|do`c vlkatowl
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8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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bg Cd gbv ?: eo`. Tml alhhq slvl tml` skqmld tsoal sotm LFQQ k`d
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k AHQE.
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bfqlvwld b` k AHQE -4==%`e l}aotktob` k`d
8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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Ckdbho`o|e doqv|ztq o`tvkalhh|hkv Ak6) mbelbqtkqoq
Tml hbs%kg`oty st|bvlqal`t Ak6)
zvbfl Gh|b 1%KE skq |qld
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l}zbq|vl bg `l|vb`q tb Cd. Cd -:.6( 6( bv 6: hE/ dod `bt
o`d|al amk`clq o` o`tvkalhh|hkv Ak6) hlwlhq sotmo` 6: eo`
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hlwlhq -Goc. 6f k`d a/.
Ckdbho`o|e ak|qlq k vkzod lhlwktob` o` o`tvkalhh|hkv VBQ
hlwlhq
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o`tvkalhh|hkv VBQ o` m|ek` howlv alhh ho`l -Ho| lt kh. 6::1/.
O`tvkalhh|hkv VBQ zvbd|atob` skq bfqlvwld b` k AHQE
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8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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btmlv LV qoc`kho`c cl`lq( q|am kq FoZ( KTG4( KTG7( k`dAMBZ -Goc. 4f/.
L}zvlqqob` bg tml LV elefvk`l%k`ambvld zvbtlo` FoZ"
CVZ3= k`d btmlv LV qtvlqq%kqqbaoktld zvbtlo`q -AMBZ(
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mocmlv -Goc.
8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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zvbd|atob` bg LV qtvlqq ekilvq -Gocq 4 k`d -o/ tml OVL;%]FZ;
zktmsky( o`doaktld fy qzhoald ]FZ; eV@K -Goc. 4/ k`d
o`avlkqld l}zvlqqob` bg CVZ3= |zb` Cd tvlktel`t -Goc.
8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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-k/ -a/
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Goc. 7 K`tob}odk`t @KA zvbtlatq alhhq gvbe dlktm fy dlavlkqo`c VBQ
zvbd|atob` k`d LV qtvlqq o` zvoekvy a|ht|vld abvtoakh `l|vb`q o`d|ald
fy 6: hE Cd -k/ Cd%o`d|ald zvbd|atob` bg alhh|hkv VBQ oq dlavlkqld
fy @KA tvlktel`t o` zvoekvy a|ht|vld `l|vb`q -f/ @KA zvlwl`tq alhh
dlktm o`d|ald fy Cd -a/ Cd%o`d|ald l}zvlqqob` bg LV qtvlqq%vlhktld
zvbtlo`q oq fhbaild fy @KA Dktk vlzvlql`t elk` QD gvbe tmvll
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8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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Qo`al LV oq k` o`tvkalhh|hkv Ak6)
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6::=/. Kq qmbs` o` Goc. 6( Cd b hy ak|qlq qoc oak`t
lhlwktob` bg Ak6) kgtlv ?: eo` o`a|fktob` -Goc. 6/( smoam oq
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1: eo ( Goc. 1/. Ab`qodlvo`c tml LV akhao|e z|ez oq
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8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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Amkvoq H.( Kzbqtbhbq ^.( Qtkektobq T.( M|qqke K. M.( Gbtlo`o K.( Lhl`k
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tlatowl vbhl bg H%ayqtlo`l tbskvdq tml lgglatq bg qmbvt%tlve
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Fobeltkhq 66( 16?11
8/2/2019 Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.
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Qeotm E. O. k`d Dlqme|im E. -6::3/ L`dbzhkqeoa vltoa|h|e qtvlqq%
o`d|ald kzbztbqoq vl{|ovlq fk} gbv abeeotel`t k`d Kzkg%; gbv
l}la|tob` o` zvoekvy `l|vb`q. Alhh Dlktm Dogglv. ;4( ;:;;;:;?.
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oq eldoktld fy tml l`dbzhkqeoa vltoa|h|e qtvlqq zktmsky o`wbhwo`cAMBZ. Alhh Dlktm Dogglv. ;;( 4:14;