Org Chart Grupo Azevedos

Thegest SGPS, SA

AlfrarentThegest Imobiliária

Sodiz

Training Grupo Azevedos

Portugal Brasil Moçambique / Angola

1984 Lab. Azevedos

1989 Quimedical

1992 Laifarma

1994 Sofarimex

1997 DLA Medis

1998 Farmoz + Farmobraz1998 Farmoz + Farmobraz

1999 Medifarm

2001 Laboris Ltda

2003 Laboris SA + Ferrer Azevedos

2004 Laboris SGPS

2006 Thegest SGPS + Alfrarent Sodiz

2007 Thegest Imobiliaria Medinfar

2008 Analytics

2009Orbispharma

2010 Thegest S.A. Sogefarm

Sales evolution GRUPO AZEVEDOS

100.000

120.000

140.000

160.000

EVOLUÇÃO VENDAS AZEVEDOS

0

20.000

40.000

60.000

80.000

K€u

ros

ANO

Grupo Azevedos

Technical Operations �Azevedos Group leads the production of medicines in

Portugal

� Trough our Sofarimex plant :

� Focused in Small and Medium series� Focused in Small and Medium series

� High technological capacity

� Continuous Investments supports technological

innovation

�Sofarimex capacity supports Azevedos Group

abroad

<1.000 2

1.000-2.500 4

2.500-5.000 8

5.000-10.000 5

15.000-20.000 1

>30.000 3

Total 23

A Portuguese Manufacturing of

small and medium European

series of pharmaceuticals

To be a reference among the Pharmaceutical To be a reference among the Pharmaceutical

Industry.

To earn our partners trust trough the competence

and rigor of our work and sharing the values

which we believe.

High Quality Standards

Customer Service

insourcinginsourcing vs outsourcingvs outsourcing

Customer Service

Market driven cost of goods

SpecialisationProcess development

Validation

�Quality

�Flexibility

�Competitiveness

�Grow & Development

�Pharmaceutical forms

�Batch size

�Quick Set-up

�Standardisation

�Quality

�Flexibility

�Focus

�Capacity

20022002 20032003 20042004 20052005 20062006 20072007

InvestmentInvestment 3.329.1533.329.153 1.380.5721.380.572 908.071908.071 1.671.7821.671.782 1.868.8231.868.823 3.508.2923.508.292

Net AssetsNet Assets

2002 2003 2004 2005 2006 2007

Investment 3.329.153 1.380.572 908.071 1.671.782 1.868.823 3.508.292

Net Assets

2008

4.639.116

Net AssetsNet Assets 25.481.76125.481.761 22.269.42522.269.425 20.006.27520.006.275 19.411.81419.411.814 17.838.79417.838.794 20.561.37720.561.377

VABVAB 9.519.9939.519.993 11.683.07611.683.076 10.069.56010.069.560 9.884.2519.884.251 9.771.8499.771.849 8.363.4258.363.425

Net Assets 25.481.761 22.269.425 20.006.275 19.411.814 17.838.794 20.561.377

VAB 9.519.993 11.683.076 10.069.560 9.884.251 9.771.849 8.363.425 11.085.690

24.784.310

�Contract manufacturing

�Development

�New Freeze Dyring plant

�New R&D plant

�New Freeze Dyring plant

�3rd Freeze dryer

�9.000.000 vials /year�9.000.000 vials /year

�Up to 9.000.000 € /year

�6.000.000 € investment

�New R&D GMP plant

�Lab, pilot & scale-up batches

�1.000.000 € investment�1.000.000 € investment

�CRO and Co-development

�8 products in progress

�23 products to start

IP & Supply

Tablets 2.000.000.000Capsules 350.000.000

Blister 110.000.000Bottles 7.000.000

Liquids 12.000.000Liquids 12.000.000Ointments 5.000.000

Lyophilised vials 9.000.000

TotalTotal 76.000.00076.000.000

Syringe Vet 3.000.000

Definition:

Quality Control

Solids

Liquids

Steriles

Semi-Solids

Development Area

6

10

Área Expansão

Definition:

Solids

Liquids

Semi-Solids

Dispensing

Expansion Area

Linha 1 Linha 2

Linha 4

Linha 3

Definition:

Reception

Expedition

SamplingSampling

Manual

Warehouse

Automatic

Warehouse

LyophilizedLyophilized areaarea Peopleaccess

Materials access

Clean corridor

Asseptic Areaaccess

Technical area

Packing room

access

Asseptic corridor

275 formulations

650 products

39,0 MU

30,5 M€650 products

50 direct customers

30,5 M€

217 employees

34 countries

•Finished product 1400 batchs•Raw materials 800 lots•Packaging materials 2630 lots

•Active ingredients 250 items•Excipients 500 items•Packaging materials 2200 items

24,8%

5,4%

39.120.000 39.120.000 unitsunits

69,8%

solids liquids steriles

ProductionMUnits

30.000

35.000

40.000

45.000

SalesM€

20.000

25.000

30.000

0

5.000

10.000

15.000

20.000

25.000

96979899'00'01'02'03'04'05'06'07080910

5.000

10.000

15.000

20.000

96979899'00'01'02'03'04'05'06'07080910

Sanofi Aventis

Mepha

AET

Tecnimede

Virbac

Azevedos

GES

GSK

OthersOthers

CPH

Novartis

Midas

Farmaprojects

Menarini

Betapharm

Tecnifar

CCD

Rotapharm

Chefaro

Pharmascience

SIT

Germed

23%

1%1%2%1%2% 6%

63%

Portugal Europe Africa CanadaSouth America Central America Russia Japan

Asia Middle East

34%

7%

3%3%

2%2%

2%2%

2% 2% 2% 2% 2% 1% 1% 1%

12%9%

7%

PORTUGAL FRANCE SPAIN UNITED KINGDOM POLAND PERSIAN GULF

ITALY GERMANY HOLLAND BELGIUM UKRANY BALTIC STATES

SWITZERLAND ECUADOR ENGLAND RUSSIA CANADA CZECH REPUBLIC

GREECE HUNGARY CENTRAL AMERICA SLOVENIA LIBYA NOT APPLY

AFRICA MALAYSIA BRASIL IRAQ CAPE VERDE IRELAND

SERBIA JAPAN SWEDEN DENMARK SOUTH AFRICA FINLAND

MOZAMBIQUE LITHUANIA MOROCCO

Units

200002500030000350004000045000

71%77%

Export

Local

Total

05000

100001500020000

00 01 02 03 04 05 06 07 08 09 10

57 %

15 %

30 %37 %

49 % 49 % 53 %

65 %62 %

CustomersCustomers

SofarimexSofarimex

SupliersSupliers CustomersCustomers

SupliersSupliers AreaArea

DemandsDemands

CustomersCustomers AreaArea for Materiaisfor Materiais

CustomersCustomers AreaArea ProductionProduction PlanPlan

ProductionProduction ControlControl

DeliveriesDeliveries

� Formulations� Manufacturing Process� Analytical Methods� Analytical Methods� Stability studies�GMP environment

cGMPcGMPISO 9001ISO 9001ISO 14001ISO 14001

217

ISO 14001ISO 14001OHSAS 18001OHSAS 18001

29 %

General Manager

Manuel J. Oliveira

1321484414 6

Q. Assurance Quality Cont. Solid Engineering DevelopmentLogisticsLiquid

52

HSDHSD 5050 10 %10 %

IndirectsIndirects 92 44%92 44%

Direct labor 125Direct labor 125 56%56%

Q. Assurance

G. Lourenço Mª José

Quality Cont. SolidForms

Engineering

V. Daniel

Development

E.Correia

Logistics

V. Angelo

LiquidForms

Mª CarmoR. Marques

217217

217217

Quality

Eng & Maintenance

Production

Logistics

D&M

Others

It’sIt’s a a mattermatter ofof skillskill, , desiredesire andand absolutelyabsolutely

focusedfocused concentrationconcentration !!