G6P

ribulose-5-Pxylulose-

5-P

sedoheptulose-7-P

F6P

Ga3P

F6P Ga3P

erythrose-4-P

6-P- D-gluconate

ribose-5-P

Zwf

GndAGntZ

Tkt

Tkt

ribose-1-P

DeoB

6-P - gluconolactone

YwjH

YkgB

Rpe

YwlF

D-arabino-hex-3-ulose-6P

HxlA

2-dehydro-D-gluconate

D-gluconate

YvcT

xylosexylulose

XylA

deoxyribose-1-P

deoxyribose-5-PDrm

DeoC1 DeoC2

TrxA (ox)

TrxA (red)

NrdE NrdF YumC TrxB

PunADeoD

purinenucleoside purine

Prs ribos

e-5-

P

PurF

glycine

PurD

folic acid

PurN

PurS

dGMP

dAMP

adenine

hypo -

xanthineApt

PurB PurC PurE PurM PurL

PurQPurK

folic acid

PurHPurH

IMP

PurA

âden

ylos

ucci

nate

PurB

GuaB

fumarate

ADPAMP

AdkNdkATP

dADP

RNA

DNA dATP

NrdE NrdF

Ndk

GuaANdk XMP

GD

P

RNA

GM

P

GTP

dGD

P

DNA dGTP

NrdE NrdF

xanthine

Xpt

guanine

Gmk

Ndk

aspartate

HprT

RNA

Pnp

Adk

RNAPnp

Gmk

HprT

Apt

amino imidazolecarboxamide

PbuXPbuG

PbuG

GuaC

GuaD

deoxyadenosine

Dck

RpoARpoBRpoCRpoE

RpoARpoBRpoCRpoE

DnaN HolBDnaX PolAHolA PolC

ADP-ribose

NudFYjhB

Ade

pppGpp

RelA

DnaN HolBDnaX PolAHolA PolC

ribos

e-1-

P

PgcADrm

MurE

glucosamine pyruvate

MurG

UDP-N-acetylmuramate

UDP-N-acetylglucosamine

glucosamine-6-P

F6P

GlmSglutamine > glutamate

Glucosamine-6-PN-Acetyl

GlmU

UDP-N-acetyl

MurAA MurAB

MurB

GlmM

glucosamine-1-P

GlmU

MurC

UDP-MurNAc-L-Ala

UDP-MurNAc-L-Ala-D-Glu

MurD

UDP-MurNAc-L-Ala-γ-D-Glu-meso-2,6-diaminopimelate

UDP-MurNAc-L-Ala-γ-D-Glu-meso-2,6-diaminopimeloyl-

D-Ala-D-Ala

MurF

alanine

D-Ala-D-Ala

Ddl

Und-PP-MurNAc-L-Ala-γ-D-Glu-meso-2,6-diaminopimeloyl-

D-Ala-D-Ala

MraY

undecaprenyl-P

UMP

Und-PP-MurNAc-(glcNAc)-L-Ala-γ-D-Glu-meso-2,6-diaminopimeloyl-D-Ala-D-Ala

UDP-GlcNAc

peptidoglycan

PonA PbpB DacA YodJ

alanineundecaprenyl-PP

UppP1 UppP2

ManNAcMnaA

L-glutamateRacE

D-glutamate

glucosamine-1-PN-acetyl

1-deoxy-D-xylulose-5P

Ga3Ppyruvate

Dxs

2-C-methyl-D-erythritol-4P

Dxr

IspD

IspE

IspF

IspG

IspHIspH

dimethylallyl -PPisopentenyl -PP

IspA

geranyl -PP

farnesyl -PP

undecaprenyl-PPUppS

IspA

geranyl -geranyl-PP

heptaprenyl-PP

IspA

HepTHepS

glycerone-3 -P

glycerol-3 -P

GpsA GlpD

glycerol

GlpK

CDP-glycerol

TagD

1-acyl-sn-glycerol-P

PlsX

acetyl-CoA

glycerone

GldA

acetyl CoA

FabD

malonyl -CoA

acetyl -ACP

acyl-ACP

3- Keto- acyl-ACP

3-hydroxy -acyl -ACP

2,3 -enoyl -ACP

FabF

FabGYoxDYtkKYvaGBLi01605

FabHA

FabI FabL

malonyl -ACP

AccAAccB

AccCAccD

FabHA

acyl- PO4

PlsXvaline, leucine,

isoleucinebranched chain acyl-CoA

BcdIlvKBLi02962

LpdV BkdAABkdABBkdB

FabHA

FabZ

acyl-G3Pphosphatidic acid

YhdO

YhfJYqhM

lipoic acid

YhfJYqhM

lipoyl-AMP

protein-N6-(lipoyl)-lysine

LipA

lipoyl-[acp]

octanoyl-[acp]

LipAprotein-N6-(octanoyl)-lysine

YjbM

UDP

NrdE NrdF

dUTP

PyrG

PyrAAPyrAB

carbamyl- P

glutamine

CarA CarB

aspartate

Car

bam

oyla

spar

tate

CT

P

UT

P

Ndk PyrH PyrF PyrC

dC

MP

Cmk NrdE Ndk

CD

P

NrdF

dC

DP

dC

TP

DNA

RNA RNA

RpoARpoBRpoCRpoE

UD

P

UM

P

uracil

UppPyrR

Ndk

dT

TP

Ndk

dT

DP d

UM

PDNA dUDP

Ndkuridine

PyrD

CMP

Cmk

cytidine

RNA RNA

Pnp Pnp

PyrBPyrE

cytosinePdp

ThyA

dT

MP

PyrP

Udk

Udk

Tmk

Tmk

DnaN HolBDnaX PolAHolA PolC

DnaN HolBDnaX PolAHolA PolC

uridineBLi02252

AckA

acetate

acetyl-PPta

acetyl-CoA

PdhC PdhD

PdhA PdhB

citrate

oxoglutarate

oxalacetate

CitZ

CitB

FumC

fumarateIcd

Mdh

OdhA OdhBPdhDSucC

SucD

SdhA SdhB

CitA

pyruvate

PEP

G2P

G3P

Ga1,3bP

GapATpiA

Pgk

PgmYhfR

Eno

Pyk

UD

P-g

alac

tose

GalEBLi03803

G6P

F6P

Ga3P

Pgi

PfkA

FbaA

G1P

UD

P-g

luco

se

GtaB

PckA

PycA

YtsJMleAMalS

methylglyoxal

MgsA

2-acetolactate

AlsS

GlpD

GlpKglycerol

glycerol-P

glucose (ex)GlcK

fructose

GmuE

UDP-GlcA

TuaD

mannose-6-P

Pmi

YpqE

AcsAYtcI

AlsD

2-acetoin butane-2,3-diol

BLi02066

GlpX

PpsBLi00634

PgcA

acetaldehyde

DhaSYfmT

MmgE

2-methylcitrate2-methyl-cis-aconitate

CoaBC CoaD

deph

osph

o-C

oA

CoA

pantetheine

CoaXCoaX

N-pantotheonyl-cysteine

CoaBC

(R)-

pant

othe

nate

CoaX

(R)-pantoate

PanC

YlbQ

PanBIlvKBLi02962

valine

L-as

parta

teβ

-ala

nine

PanD

HemE HemHHemD

prot

ohem

e

HemB

5-am

ino-

levu

linat

e

urop

orph

yrin

ogen

III

HemC

copr

opor

phyr

inog

en II

Ipr

otop

orph

yrin

ogen

IXpr

otop

orph

yrin

IX

HemL1HemL2

glutamate-1-semialdehyde

L-glutamyl-tRNA

HemYHemZ

prec

orrin

2

SirA SirASirB

siro

hem

e

NA

DP

NadE NadC

NA

D

NA

D

NadA NadB

imin

oasp

arta

te

aspa

rtat

e

PncBnicotinate

PpnK1PpnK2

nicotinamidePncA

biotin

S-adenosylmethionine

carboxyhexanoate

6-carboxyhexanoyl-CoA

alanine

8-amino-7-oxononanoate

S-adenosyl-4-2-methylthio-oxobutanoate

7,8-diamino-nonanoate

dethiobiotin

BioB

BioD

BioA

BioF BioW

biotinyl-5`-AMP

BirA

HisG

histidine

PRPP

R5P

HisD

HisI HisI

HisC

Prs

HisAHisFHisH

HisS HisZ

HisB

cysteine

CysI

CysJ

sulfateadenylsulfate

phosphoadenylsulfate sulfite

CysCSat

serine

CysS

CysKMccAYtkP

SerS

GlyQS

G3P

glycine

GlyA

SerA

SerC

sulfideCysE

pyruvateOAS

CO2

GcvPAGcvPBGcvT

BLi01778

SdaAA SdaABIlvA

pyruvateMetCMccBPatB

sulfonate

SsuD

SsuA, SsuB

Hom

oxalacetate

S-adenosyl

methionine

ThrS

LysS

AspS

lysine

threonine

methionine

ThrZ

FmtformylmethionyltRNA

MetS

AspB

LysC

Asd

ThrC

MetI

MetC MccBPatB

MetE MetHYitJ YxjG

MetK

DapF

DapAMetA

YtjP

DapG

LL-2,6-diaminopimelate

N-succinyl-2, 6-diaminopimelate

N-succinyl-2-amino -6-oxopimelate

tetrahydrodipicolinate

2, 3-dihydrodipicolinate

DapB

pyruvate

AsnS

aspartateAnsAAsnB

asparagine

YclM

YkrV PatA

formylmethinonineYkrB

DapH

DapL

SpeE

dSAM

MTAMtnN

MtnK

MtnA MtnB/XMtnX

MtnW

MtnB/X

MtnD

MtnV

ThrB

fumarate

AspAAnsB

LysA

meso-2,6-diaminopimelate

PdxA

2-ox

o-3-

hydr

oxy-

4-ph

osph

obut

anoa

te

(2S

)-2-a

min

o-3-

oxo-

4-ph

osph

ono-

buty

anoa

te

spontaneous

pyrid

oxin

e-P

PdxSPdxT

o-ph

osph

o-4-

hydr

oxy-

L-threonine

SerC

pyrid

oxal

-5-P

ribulose-5-PGa3P

pyrid

oxal

ThiD

MenFDhbC

chor

ism

ate

isoc

horis

mat

e

DhbB

baci

lliba

ctin

DhbBDhbEDhbF

DhbA

ProS

tryptophane

PEP

erythrose-4-P

AroA AroF

AroAAroHPheBAroE

AspB

AspB

TyrA

TrpATrpBTrpC

AroAAroBAroDAroQ

tyrosine

phenylalanine

TyrS

PheST

TrpS

alanine

pyruvate

oxobutyrate

pyruvate leucine

valine

threonine

isoleucine

AldBLi04275

PdhAB

IlvB IlvH

IlvB IlvH

IlvC

IlvC

IlvD

IlvD

IlvA

AlaS

LeuA

LeuCLeuD LeuB LeuS

IleS

ValS

ThrS

ThrZ

Dat

ArgSoxoglutarate

glutamate

glutamine

ornithine

arginine

GltX

Glu-tRNA(Glu)

Glu-tRNA(Gln)

GatA GatB

GatC

GlnA

GltA

ArgH

ArgG

ArgFArgDArgC

RocFBLi00584

glutamineCarA CarB

ArgJ ArgB

GltB

GltX

Gln-tRNA(Gln)

citrulline

urea

putresc

ine

spermidine

S-adenosylmethyl

thiopropylamine

SpeE

agmatine

SpeB

GudBRocG

BkdAABkdAB

BcdIlvK

LpdV

glutamine

IlvK BcdBLi02962

FadBYhaR

PyrAA PyrAB

HisC

HisC

glutamate-5- semialdehyde

RocD

carb

amoy

l- P

pyrro

line-

5-ca

rbox

ylat

e

prolineglutamate

glutamyl-PProA

AlsS

IlvK BcdBLi02962

IlvK BcdBLi02962

AlsS

RocA

RocA

TrpE

L-alanineAlr

NosA

PheA

ProB

ProI

SpeA

TrpD

TrpF

O-D-alanyl-poly(ribitol-P)

DltA

RibBA

5-am

ino-

6-(5

`-P-

ribity

lam

ino)

urac

il

GT

P

rib

ulo

se-5

-P

RibBA

RibD RibD RibH RibE RibC RibC

3,4-

dihy

drox

y-

2-bu

tano

ne-4

-P

ribof

lavi

n

FMN

FAD

FmnP

5,10

-met

hyle

ne-

THF

Sul

DfrADH

F

TH

F

folate

DfrA

FolE FolE2

FolK

dihy

dron

eopt

erin

FolB

DfrA

GTP

FolE FolE2

FolE FolE2

FolE FolE2

4-aminobenzoate

Sul

PabC

4-amino-4-deoxychorimate

PabAPabB

chorismate

Fhs 10-fo

rmyl

-TH

F

FolD

5,10

-met

heny

l-TH

F

FolD

MoaDMoaE

MoaC

cPM

P

mol

ybdo

pter

in

ThiF

glycine

[Thi

S]-C

OS

H

GoxB

iminoglycine

ThiC

1-(5

`-ph

osph

orib

osyl

)

-am

inoi

mid

azol

[Thi

S]-C

O-A

MP

ThiD ThiD

ThiE

ThiI ThiF

[Thi

S]-C

OS

S-

[Thi

F]

ThiG

thia

min

P

YsnA

thia

min

diph

osph

ate

ThiM

5-(2

-hyd

roxy

ethy

l)-

4-m

ethy

lthia

zole

ThiS

ThiI

[Thi

S]-C

O-A

MP

NifSYvrO Csd

[Thi

I]-S

H

ThiI

[Thi

I]-S

SH

cysteine

ABC transporter

YdbJ, YtrBYhcH, LanHLanT, LanF

YhcILanI

CbiO2, YkoDcobalt/ nickel

peptidesAppAAppAAAppABiron complex FeuA

FhuD

MntAmanganese/ iron

MsmXmultiple sugars

OppA

OppDOppF

OpuAAglycine betaine/ prolin OpuAC

sulfonate/ nitrate/ taurin SsuA SsuB

AdcAzinc

YckI YqzI

polar amino acids

YclQ

YfiY, YvrC, YxeB, YhfQBLi03657

YckB, YckK

antibiotics

D-methionine MetQYhcJ

YlmA, YusVYclP

MetN1 MetN2

molybdate YvgL

AppDAppDA

AppFAppFA

BLi02688

AppBAppBA

AppC

OppB

OppC

OpuAB

osmoprotectants OpuCBOpuCD

phosphate PstS

BLi00973MetP

YkoC

ThiT, ThiVThiX

ArtQarginine

copper CpoA

LysPlysine

cystine TcyCTcyA

thiamin ThiW

ArtR

maltose/ maltodextrin

MalQ

substrate permease ATP binding binding

DppE

OpuCAOpuCC QcrAcytochrome c reductase

NdhNamA

NADH dehydrogenase

F-type ATPase AtpD AtpG

CtaEcytochrome c oxidase

QoxC

AtpA AtpH AtpC AtpB AtpF

QcrB QcrC

CtaD CtaC

QoxB QoxA

YumCYwrOBLi00385

NAD(P)H dehydrogenase

membrane bioenergetics

substrate permease ATP binding binding

AtpE

TagHteichoic acid