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Functional Biochemistry Clinical Reference Guide
Chris Astill-Smith, DO, ND, DIBAK Casey Reardon, DC
Credits Contact information Chris Astill-Smith Epigenetics International, Ltd. The Old Coach House 21 Church Street Market Lavington Devizes, Wiltshire SN10 4DU Phone: 01380 800105 Email: info@epigenetics-international.comwww.epigenetics-international.com Casey Reardon Email: [email protected] Copyright 2008-2012 Casey Reardon All Rights Reserved This manual cites information from the following sources: Guyton’s Physiology Harper’s Biochemistry Applied Kinesiology Synopsis 2nd Edition by David Walther, DC, DIBAK A New Earth by Eckart Tolle Water Crystal Healing by Massuro Emoto Power Vs Force by David Hawkins The Linus Pauling Institute (lpi.oregonstate.edu) Common Glandular Dysfunction by Walter Schmitt, DC, DIBAK, DABCN Healing Without Medication by Robert Rister Notes from the following seminars make up this manual: Omega System 1-10 Developing a Total Nutritional Profile Ear, Nose, Throat, Mouth Adrenal Exhaustion Male and Female Hormones Parasites Itchy Patient Menstrual Disorders Toxicity pH Acid Base Balance Children Updates 2007 and 2008 Sugar Metabolism Annual Conference 2008 Arthritis Belgium 2009 Preliminary Procedures Sugar and Arthritis Genito-Urinary System Neurobehavioral Disorders Annual Update 2009 Memory Annual Update 2010 Common Respiratory Ailments Disclaimer The material in this book is for educational purposes only. It is always the treating doctor’s responsibility to determine what treatment a patient needs. The methods covered in this book are not meant to diagnose, treat, prevent, or cure any diseases and should always be used in addition to, not instead of, standard examination procedures. No doctor-patient relationship is established by this book.
Procedure Outline Preliminary Procedures
1. Identify strong and weak muscles 2. TL to GV 20 weakens
a. If no i. Inspiration and expiration open – cranial
ii. Inspiration or expiration open – body structure iii. Identify B+E point that opens GV 20 – Rub 30 secs while patient TLs GV 20
b. If yes i. Inspiration and expiration close – cranial
ii. Inspiration or expiration close – body structure iii. Identify B+E point that closes GV 20 – Rub 30 secs while patient TLs GV 20
3. TL to eyes weakens a. Deep cranial fault
4. Tapping patellar reflex does not weaken opposite Latissmus Dorsi and Rectus Femoris (check both sides) a. Correct body structure superior to inferior
5. TL to now time Alarm Point does not weaken a. Correct Body Clock
6. Identify primary and secondary eye cone colors a. Red, Green, Blue
Hemisphere Dominance 7. Challenge for underfunctioning hemisphere using goggles or hands over eyes
a. If neither side weak – adjust occiput, C1, or other structural fault b. If left or right weakens challenge with brain nuclei
i. midbrain, hindbrain, cerebellum, cortex (parietal, temporal, occipital, frontal) c. Remove goggles – TL brain nuclei reflex points on head bilaterally (TL weak side first) d. Use EID / BID to identify cause(s) of underfunctioning nuclei e. Correct as indicated and repeat until both hemispheres are corrected
Energy 8. Mg-ADP weakens
a. If yes – Test Glycolysis, Ctric Acid Cycle, Electron Transport Chain nutrients b. If no – Does Mg-ADP weaken with TL to umbilicus?
i. If yes – weakness negated by tissue extracts 1. Adrenal Cortex, Adrenal Medulla, Pineal, Thymus 2. Challenge with Snowdrops
a. If weakens – gland is hyper b. If strengthens – gland is hypo
3. Determine key nutrient(s) c. Scale of ATP Energy d. Scale of Vital Energy e. Scale of Metabolism
Genomics 9. Nucleotide base (A, C, T, G, U) weakens
a. Identify SNIP – Test other bases for strengthening b. Composites: Vitamin, Coenzyme, Mineral, Sat Fat, Unsat Fat, Probiotic, Amino Acid, Saccharide
i. Narrow composites to the specific nutrient c. Test Compounds: Multiple Vitamin / Mineral, B Complex, Nutrient Phase 1+2, Homocysteine
Formula, Ostecaps d. Test Spices e. Scale of Health f. Scale of Wobble
Wellness, Methylation 10. Sodium Lauryl Sulfate weakens
a. Scale of Wellness b. Challenge against: Multiple Vitamin / Mineral, Nutrient Phase 1+2, Ostecaps, Homocysteine Formula,
B Complex 11. Test Methionine, SAM, SAH, Homocysteine, and Cystathione for weakening and strengthening
a. Identify effects of methylation defect on adjacent cycles b. Identify nutrient to restore methylation cycles c. Scale of Biochemistry d. Check nutrients against Prospective Age
B+E Point Evaluation, Neurotransmitters 12. Determine Primary Meridian
a. Test corresponding Neurotransmitter i. If positive – Determine nutrients needed to make or break down
Endocrine b. Test corresponding Hormone
i. If positive – Determine nutrients needed to make or break down Diagnostic Entry
c. Determine Optimal Diagnostic Entry (EID vs BID) d. Determine cause of meridian imbalance using Diagnostic Entry
i. Left and Up – Nutritional Deficiency 1. Composites: Vitamin, Coenzyme, Mineral, Probiotic, Sat Fat, Unsat Fat, Amino
Acid, Saccharide 2. Narrow composites to the specific nutrient
ii. Straight Left – Toxicity 1. Chemical, Radiation, Toxic Metal 2. Determine remedy 3. Identify Source – Verbal Challenges
iii. Left and Down – Structure iv. Right and Up – Dehydration
1. Determine amount of water needed v. Straight Right – Exercise
1. Scale of Fitness 2. Verbal Challenge for optimal exercise, times per week, and length per time 3. Aerobic Challenge 4. Anaerobic Challenge
vi. Right and Down – Allergy 1. Identify offending food or drink 2. Rub B+E point that negates weakness with food in mouth or vial on patient 3. Identify chemical mediators (kinin, histamine, PG, LT) and nutrients to metabolize
vii. Side to side – Energy 1. Glucose, Glycolysis, CAC, ETC nutrients 2. Kundalini meridian – cortex, medulla, pineal, thymus
viii. Circumduction – Infection 1. Bacteria, Virus, Post Virus, Parasite, Fungus 2. Determine remedy
ix. Eyes crossed on nose – Sleep 1. Determine optimal length of time to sleep 2. Does patient strengthen to melatonin or weaken to cortisol or adrenaline at nighttime
alarm point (TW, GB, LV, LU)? a. If yes – Identify nutrients to correct
Emotional 13. Eyes closed weakens
a. “The optimal emotional release for me to perform on you is… i. …To release the unconscious emotions” strengthens
1. TL to B+E point strengthens eyes closed 2. Give patient affirmation to release emotion
ii. …The Love Challenge” strengthens 1. Patient weakens to “I am loved”, “I am loving”, or “I am lovable” 2. Repeat the weakening statement 20 times every night
Preliminary Procedures 14. Is gait pattern is intact when standing? If not:
a. Identify and correct structural fault b. Patient jumps on heels 6 times c. Repeat until correct gait pattern is maintained
Energy 15. Scale of Vitality was less than 1000
a. Patient looks at light box with color corresponding to primary meridian for 15 minutes b. Patient listens to music corresponding to primary meridian
Biochemical Flowchart Key Substrate Mineral Cofactor, Vitamin Coenzyme, or other substance that is needed for the conversion Toxin or other substance that blocks the conversion Product Synthase = enzyme to convert substrate to product Product / Substrate 2
Mineral Cofactor, Vitamin Coenzyme, or other substance that is needed for the conversion Toxin or other substance that blocks the conversion
Product 2 Synthase = enzyme to convert substrate 2 to product 2 Product 2 Substrate weakens and product strengthens = underactive enzyme Test substances to enhance conversion of Substrate to Product Substrate strengthens and product weakens = Overactive enzyme Test substances to convert Substrate 2 to Product 2 When substrate is low and product is high, it may be appropriate to test substances to block the conversion of substrate to product, such as herbs in a case of low testosterone. In most cases, these substances are toxins that should not be supplemented and the best remedy is to enhance the conversion of Substrate 2 to Product 2.
GV 20 Located at the highest point on the top of the head Related to the Hypothalamus Traditional Chinese Acupuncture calls it “The Cure of 100 Diseases” Governing Vessel 20 can be used to test anything including supplements, flower remedies, homeopathics, or anything else where a weak muscle is needed. Anything that strengthens GV 20 will benefit the person, though it can’t be said, based on the test, whether it will improve their health by 1% or 100%. If something does not strengthen GV 20, it will not benefit the patient. In a well neurologically organized person, GV 20 will weaken unless the person has no stresses on their body. If GV 20 does not weaken, the patient is either perfect, just took their supplements, or is neurologically disorganized. GV 20 Procedure 1. TL to GV 20 weakens
a. Inspiration and expiration strengthen Superficial Cranial Fault i. Using B+E points
a. TL B+E points until one strengthens GV 20 – indicates primary B+E point b. Rub this point bilaterally for 30 seconds with TL to GV 20
ii. Mechanical Correction a. Respiratory adjust b. TL technique c. All in one technique
b. Inspiration or expiration strengthen Ascending Fault (see next section on Biomechanics) 2. TL to GV 20 does not weaken
a. Inspiration and expiration weaken Superficial Cranial Fault i. Using B+E points
a. TL B+E points until one weakens GV 20 – indicates primary B+E point b. Rub this point bilaterally for 30 seconds with TL to GV 20
ii. Mechanical Correction a. Respiratory adjust b. TL technique c. All in one technique b. Inspiration or expiration weaken Ascending Fault (see next section on Biomechanics)
c. RNA or DNA open GV 20 i. 2-3 capsules a day for 2-3 weeks ii. Cut the dose in half if the patient experiences any bloating (supplement is made from yeast) iii. Open GV 20 from DNA or RNA is negated by DNA or RNA Polymerase, If yes:
a. Test Zinc d. 2 hand TL anywhere on the trunk weakens i. One hand contralateral TL on trunk opens GV 20 ii. Identify B+E point that negates weakness from 2 hand TL iii. Rub bilaterally for 30 seconds while patient maintains TL to GV 20 3. Complementary color opens GV 20 a. Repeat procedure with complementary color on patient and correct as indicated b. Complementary color may also be used to keep GV 20 open during office visit Rubbing the primary B+E point in reference to GV20 will: 1. Clear most cranial faults 2. Reset the body clock 3. Indicate the primary meridian imbalance 4. Prevent muscles from not switching on and off correctly
Biomechanics Verbal Challenge “The optimal therapy for me to perform on your _____ is _____” Types of Adjustments 1. RESIST 6. Percussion 2. Manipulation 7. Drop Adjustment 3. Meridian therapy 8. Instrument assisted 4. Respiratory Adjust 9. Pelvic Blocking 5. Therapy Localization Technique 10. Any other structural correction the doctor is skilled in Treatments RESIST (Reflex Extremity and Spinal Inhibitory and Stimulatory) Technique Doctor immobilizes the segment while patient moves other joints for 60 seconds
a. Spine: Patient moves all 4 limbs for 60 seconds b. AC, SC, Sternum: Patient actively moves upper extremities for 60 seconds
c. Extremity: Patient actively moves all spinal articulations for 60 seconds d. AS ilium: While patient moves all 4 extremities either 1) SOT block under the ASIS and immobilize the SI or 2) Hold the sacrum and ischium e. Coccyx: Find the tip and hold a little superior and lateral on both sides while patient moves all 4 extremities
Resist vs. High Velocity Manipulation Patient in control Doctor in control No force Force Joint is immobilized Joint is moved Every other joint is moved Every other joint is immobile Calibrates to 1000 Calibrates to 250 Systemic fascial release Local joint release Meridian Therapy 1. TL area to be adjusted 2. Find B+E point that negates weakness 3. Rub B+E point for one minute 4. Maintain TL while rub Respiratory Adjust 1. Determine vector of positive challenge to joint 2. Inspiration or expiration negates 3. Correct with light pressure in the direction of weakness on phase of respiration that strengthened TL Technique For spine or extremity: 1. Rub hands together to generate spiral field force (tell patient you are warming your hands). This prevents the patient’s problem from moving into the doctor. 2. Doctor touches patient’s area to be adjusted with one hand and his own same area with the other hand. 3. Doctor moves his joint through a full range of motion for a minute. Doing this puts the condition of the doctor’s joint into the patient. For this technique to be effective, the doctor’s joint must be in better condition than the patient’s. For cranials: 1. Rub hands together to generate spiral field force (tell patient you are warming your hands). This prevents the patient’s problem from moving into the doctor. 2. Doctor touches thumb and finger on the patient’s closed eyes. 3. Doctor touches his own closed eyes with thumb and finger of other hand and clenches and relaxes jaw muscles for one minute.
Meridians Note what time the patient gets their symptoms (when they wake up during the night, when they feel worst, etc) All meridians are functioning always, but they are highest during their 2 hour time Lung (3am-5am) - High Inhibition (Glycine, Taurine, and GABA); High PTH; All aspects of Oxygenation.
Large Intestine (5am-7am) - Low Inhibition; Low PTH; Gut dysbiosis; Often parasitic infestation.
Stomach (7am-9am) - Low Histamine; Low Thymus; Hypochlorhydria; Low immune system; Lack of arousal.
Spleen (9am-11am) - High Histamine; High Thymus; Overactive immune due to infection or allergy.
Heart (11am-1pm) - High Noradrenaline; High Adrenalin; Excess sympathetic activity; Hyperadrenia.
Small intestine (1pm-3pm) - Low Noradrenaline; Low Adrenalin; Inadequate sympathetic activity both in the gut as
food allergy / intolerance and elsewhere; Hypoadrenia.
Bladder (3pm-5pm) - Low Serotonin; Low Cortisol; Depressed mood; Elimination of water soluble toxins (metals).
Kidney (5pm-7pm) - High Serotonin; High Cortisol; Elimination of water soluble toxins (metals).
Circulation / Sex (7pm-9pm) - High Excitation (Nitric Oxide, Glutamate, Aspartate) and both their CNS and peripheral
effects; High T4.
Triple Warmer (9pm-11pm) - Low Excitation; Low T4; Low Metabolism.
Gall Bladder (11pm-1am) - Low Acetylcholine; Low DHEA; Fat Metabolism problems (EFA, Cholesterol).
Liver (1am-3am) - High Acetylcholine; High DHEA; Detoxification.
Conception Vessel (no time) - Low Dopamine; Low Estrogen.
Governing Vessel (no time) - High Dopamine; High Estrogen / Estrogen Derivative.
Body Clock Challenge Procedure 1. TL alarm point for “Now Time” meridian weakens. If not:
a. Office correction: Patient TLs coupled meridian alarm point with dominant hand while doctor taps GV 20 60 times (2 taps per second, 30 seconds) b. Self Correction: With dominant hand, TL coupled meridian alarm point while tapping GV 20 60 times (2 taps per second, 30 seconds) with non dominant hand
Indications for Body Clock Indigestion Sleep difficulties Jet Lag Recent travel across time zones Daylight savings time Patient Self Care During travel across time zones, do self correction at 6:30pm. With dominant hand just above pubic symphysis (BL), tap GV 20 with non dominant hand. Daylight Savings Time Winter time is real time. Summer time (“spring forward”) is Daylight Savings Time. The body’s energy flow does not change but the time on the clock does.
LU LI ST SP HT SI BL KI CX TW GB LV Winter 3-5 5-7 7-9 9-11 11-1 1-3 3-5 5-7 7-9 9-11 11-1 1-3 Summer 4-6 6-8 8-10 10-12 12-2 2-4 4-6 6-8 8-10 10-12 12-2 2-4
Energy
Scale of ATP, Metabolism, Vitality
Energy Production
Sugar Handling
Kundalini Meridian
Scale of Fitness
Sports Nutrition
Weight Loss
Vital Energy Lung Dark Blue
Waves of the Danube by Iosif Ivanovici “I am open hearted and free of suppression”
Large Intestine Yellow
The Villa Medici Fountain at Sunset from The Fountains of Rome by Ottorino Resighi “I am relieved of my stubbornness and pride”
Stomach Red Siegfried Idyll by Richard Wagner “I am full of passion and willingness” Spleen Cyan Jeux de Vagues from La Mer by Claude Debussy “I am free thinking and released from obsession” Heart Yellow / Green
The Swan of Tuonela by Jean Sibelius “I am free from worry and anxiety”
Small intestine Indigo
Prelude of Act 1 Lohengrin by Richard Wagner “I am full of self love”
Bladder Violet
The Trevi Fountain at Noon from the Fountains of Rome by Ottorino Respighi “I am full of good fortune and optimism”
Kidney Green
De l’Aube a midi Sur la Mer from La Mer by Claude Debussy “I create strong bonds with others”
Circulation Sex Blue
The Blue Danube by Johann Strauss 11 “I am revitalized after fatigue and stress”
Triple Warmer Orange
The Moldau by Bedrich Smetana “I have peace of mind and relief from irritability”
Gall Bladder Dark Blue
The Valle Giulia Fountain at Daybreak from the Fountains of Rome by Ottorino Respighi “I strengthen my bonds with others and have relief from stress in relationships”
Liver Yellow
Prelude to the Afternoon of a Faun by Claude Debussy “I have a cleaner heart and body and relief from environmental stress”
Conception Vessel Green
Dialogue du Vent et La Mer from La Mer by Claude Debussy “I have relief from depression and motivation to move forward”
Governing Vessel Violet
Scene from Act 2 Swan Lake by Peter Tchaikovsky “I have relief from my rigidity and obsession”
Energy Production – ATP Energy Production Challenge Procedure 1. ATP weakens a. Free radicals, Inflammation, Oxidation
b. Identify area of focal inflammation (teeth, sinuses, tonsils, gall bladder, ICV, appendix, colon, ovary, any possible area of localized inflammation or localized chronic infection) c. Use therapy localization or organ kit to identify location of focus (TL or organ vial negates weakness from ATP) d. Test for infection (bacteria, virus, post virus, fungus, parasite). See Infection section for remedies. e. Test for toxins (chemicals, metals, radiation). See Toxicity section for remedies. f. Test for inflammation (prostaglandin, leukotriene, histamine, kinin, c reactive protein, nf kappa b, serotonin. See Inflammation section for remedies (Biochemistry, Tab 5).
2. ADP weakens, ATP strengthens a. Strengthen to Glucose Hypoglycemia i. Test: Complex carbohydrates, Cortisol, Adrenaline, Hyperinsulinism (Cr, Mg, Cinnamon, Diet)
ii. Patient should eat often to maintain blood glucose levels; Protein and fat every 2 hours. b. Strengthen to Pyruvate Glycolysis
i. Test: Magnesium, Zinc, Potassium, NAD, Iodine c. Strengthen to Acetyl CoA
i. Test: Thiamin Pyrophosphate, Riboflavin-5-Phosphate, NAD, Alpha Lipoic Acid, Magnesium ii. Test Beta Oxidation : Lipase (T3, T4, Adrenalin), Magnesium, CoA, Carnitine, Lipoic Acid, FAD, NAD, H2O, O2 (Iron, B9, B12)
d. Strengthen to NADH or FADH2 or CO2 Citric Acid Cycle i. Test: Thiamin Pyrophosphate, Riboflavin-5-Phosphate, NAD, Pantethine, Alpha Lipoic Acid, Manganese, Magnesium, AdenosylB12, T3 or T4 (Tyrosine, Iodine, Selenium)
e. Strengthen to ATP (and no other product) Electron Transport Chain i. Test: CoQ10, Iron, Sulfur, Phosphorous
f. Strengthen to Oxygen Hypoxia i. Test: Iron, Magnesium Peroxide, B12, Folic Acid Office Care: Cranials, Manubriosternal Joint, Diaphragm, Intercostal soft tissue release
Home Care: Increase exercise 3. Patient is tired and does not strengthen to ATP or weaken to ADP Toxicity a. Toxic Metals, Food Allergy, Bad Fats, Liver, Digestion, Chemicals, Radiation, Dysbiosis Lactic Acid Challenge Procedure Patient inspires fully and breathes half out. Inability to maintain this for 20 seconds indicates excess lactic acid due to a deficiency of Thiamin Pyrophosphate. OR Patient will weaken to one or more of the lactic acid vials Test: Niacin, Thiamin, Riboflavin, Oxygen (Folic acid, B12, Iron) ATP Structure Adenine + Ribose + 3 Phosphates + Magnesium ATP Use 1/3 – Active process of the cellular Sodium / Potassium pumps 1/3 – Enzymatic activity 1/3 – Energy production for contractile (muscle) and non-contractile (cilia) tissues Symptoms of Low ATP Tired vs Toxic Loss of energy Tired Deficient in nutrients needed to make ATP Pain Tired after exertion Difficulty in memory recall Toxic Overload of internal or external chemicals Always tired, not relieved by rest
Energy Production – ATP ATP Yield Aerobic Anaerobic Glycolysis: Glycolysis from Glucose: Phosphoglycerate Kinase 2 Glucokinase -1 Pyruvate Kinase 2 Phosphofructokinase -1 G-3-P Dehydrogenase 6* Phosphoglycerate Kinase 2 Glucokinase and PFK -2 Pyruvate Kinase 2 Net ATP per Glucose 8 Net ATP per Glucose 2 Citric Acid Cycle: Glycolysis from Glycogen: Succinate Thiokinase 2 Glucokinase bypassed Net ATP per Glucose 2 Phosphofructokinase -1 Phosphoglycerate Kinase 2 Oxidative Phosphorylation in ETC: Pyruvate Kinase 2 8NADH+H+ 24 Net ATP per G-6-P 3 2FADH2 4 Net ATP per Glucose 28 Total ATP made Aerobically 40 Total Net ATP per Glucose 38 * Could be 4 depending how NADH is used Free Radicals and Exercise Exercise demands increased ATP production. Free radicals are produced in the ETC and are neutralized by CoQ10. Statin drugs block CoQ10 production and allow increased free radical damage. Sources of Fuel During ExerciseAerobic Anaerobic Type 1 (Oxidative red) fibers Type 2 (Glycolytic white) fibers 0-4 mins blood glucose 1-5 secs Creatine Phosphate 4-18 mins liver glycogen 5-10 secs Glucose from muscle glycogen 18-70 mins muscle glycogen is metabolized by anaerobic glycolysis 70-4000 mins adipose tissue and triglycerides leading to lactic acid formation. Gradual depletion of muscle glycogen Rapid depletion of muscle glycogen.
Type 1 Slow twitch Type 2 Fast twitch Myosin ATPase Low High Energy utilization Low High Mitochondria Many Few Color Red White Myoglobin Yes No Contraction rate Slow Fast Duration Prolonged Short Marathon (Aerobic) Sprinter (Anaerobic) Type 1 (oxidative) fibers are used predominantly Type 2 (glycolytic) fibres are used predominantly ATP is the major energy source throughout Creatine phosphate is the major energy source
during the first 4-5 seconds Blood glucose and free fatty acids are the Glucose from muscle glycogen metabolized major fuel sources by anaerobic glycolysis is the major fuel source Muscle glycogen is slowly depleted Muscle glycogen is rapidly depleted
Energy Production – Glycolysis and Lactic Acid Production
Glucose
Mg ATP Biotin NADP
Glucose-6-Phosphate Ribulose-5Phosphate Mg Biotin, Mg, ATP
Fructose Fructose-6-Phosphate Ribose-5-Phosphate Mg Mg ATP Thiamin Pyrophosphate
Transketolase Fructose-1,6-phosphate
Dihydroxyacetone Phosphate Mg Glyceraldehyde-3-Phosphate NAD Zinc NAD NADH Zinc NADH Iodoacetate Triglycerides Glycerol-3-Phosphate
1,3-Bisphosphoglycerate Mg ATP Mg ADP ATP Glycerol Electron 3-Phosphoglycerate Transport Chain Mg (Oxygen; Preferred 2-Phosphoglycerate Pathway) Mg Flouride Phosphoenolpyruvate Mg ADP ATP NAD NADH K+ Hypoxia Lactic Acid Pyruvate Zinc, NAD
Citric Acid Cycle
Energy Production – Citric Acid Cycle Hypoxia, NADH, B1 deficiency
Pyruvate Lactic Acid NAD
Urea Cycle B1 NAD NADH+H+
FAD FADH2 Aspartic Acid Mg, Lipoic Acid
P5P Acetyl CoA
Vit C NH3 Mg Oxaloacetic Acid Citric Acid NAD NADH+H+ Zinc Mg Malic Acid Flouroacetate H2O Modulated by T3 and T4 Fumaric Acid Cis-Aconitic Acid FAD FADH2 Sulfur, Iron Malonic Acid (B12 deficiency) Succinic Acid Isocitric Acid NADH+H+ NAD Succinyl CoA Oxalosuccinic Acid B1, Lipoic Acid NAD NADH+H+ Mn FAD Arsenite
Alpha Ketoglutaric Acid
NH3 P5P NAD P5P Excess NH3
GABA Glutamic Acid Glutamine
Poisons That Uncouple the Electron Transport Chain 1. Rotenone prevents the transport of electrons. 2. Malonate is a competitive inhibitor of succinate dehydrogenase. 3. Azide inhibits electron transfer at Complex IV. 4. Oligomycin is an antibiotic given to farm animals. 5. Dicyclohexylcarbodiimide Dinitrophenol (DCCD) is a weak acid. Its base dinitrophenate accepts H+ producing the undissociated acid dinitrophenol and is called an electron uncoupler. 6. TMPD is an artificial electron donor. 7. Carbonylcyanide another electron uncoupler.
Functional Genomics
Scale of Health, Wobble
Functional Genomics Nucleic Acid Mutation Procedure 1. Challenge for weakening with each of the five nucleotides – Adenine, Cytosine, Guanine, Thymine, Uracil 2. Test other 4 bases against weakening base to identify SNIP 3. Cross challenge weakening base against:
a. Composites: Vitamin, Coenzyme, Mineral, Saturated Fat, Unsaturated Fat, Probiotic, Amino Acid b. Compounds: Multi Vitamin/Mineral, B Complex, Nutrient Phase 1+2, Homocysteine Formula, Ostecaps c. Spices
4. Narrow any composites to the specific nutrient 5. Determine dose of nutrient that negates all available markers and symptomatic areas 6. Patient may need nucleotide base cream topically – use the cream with the base that has been replaced DNA is made up of four bases: RNA is made up of four bases: Purines Pyrimidines Purines Pyrimidines Adenine Double bonded to Thymine Adenine Double bonded to Uracil Guanine Triple bonded to Cytosine Guanine Triple bonded to Cytosine Base + Ribose = Nucleoside + Phosphate = RNA Nucleotide Adenine (A) Adenosine Adenosine Monophosphate (AMP; Adenylate) Guanine (G) Guanosine Guanosine Mono Phosphate (GMP; Guanylate) Cytosine (C) Cytidine Cytidine Mono Phosphate (CMP; Cytidylate) Thymine (T) Thymidine Thymidine Mono Phosphate (TMP; Thymidylate) Uracil (U) Uridine Uridine Mono Phosphate (UMP; Uridylate) Base + 2’-Deoxyribose = Nucleoside + Phosphate = DNA Nucleotide Adenine (A) Adenosine Deoxy Adenosine Mon Phosphate (dAMP; Deoxyadenylate) Guanine (G) Guanosine Deoxy Guanosine Mono Phosphate (dGMP; Deoxyguanylate) Cytosine (C) Cytidine Deoxy Cytidine Mono Phosphate (dCMP; Deoxycytidylate) Thymine (T) Thymidine Deoxy Thymidine Mono Phosphate (dTMP; Deoxythymidylate) Uracil (U) Uridine Deoxy Uridine Mono Phosphate (dUMP; Deoxyuridylate) Mutation Coenzyme Infections Food Function A > C *Methylcobalamin Rubella Orange Pepper Methylation A > G Thiamine pyrophosphate Morbillinum Pea Decarboxylation A > T SAM Influenza Kiwi, Papaya Methylation A > U FAD(H) Hepatitis Blueberry Red-Ox C > A *Adenosylcobalamin Poliomyelitis Yellow Pepper Alkylation C > G Thiamine triphosphate Tuberculosis Beans Acetylation C > T Methyl H4 Folate Varicella Broccoli Methylation C > U *Vitamin C Anthrax, Herpes Simplex Rose Hips Red-Ox G > A NAD(H) Candida, Parotitis Blackcurrant Red-Ox G > C *Carboxybiotin Chlamydia Pumpkin Carboxylation G > T *Pyridoxal-5-phosphate Gonorrhea Red Pepper Decarbox, Transamination G > U H4 Biopterin Coxsackie Broad Beans Hydroxylation T > A NADP(H) Candida, Pertussis Blackberry Red-Ox T > C FMN(H2) / R5P Hepatitis Bilberry Red-Ox T > G *Lipoic Acid Herpes Zoster Watermelon Acyl Transfer T > U *CoQ10 Mononucleosis Black Grape Red-Ox U > A Folinic Acid Syphilis Raspberry 1 Carbon transfer U > C Methyl H4 Folate Adeno virus Gooseberry 1 Carbon Transfer U > G CoA Salmonella, Varicella Elderberry Acyl Transfer U > T Methylene H4 Folate Human Papilloma Green Pepper Methylation of Uracil Amino Acids Alanine Glutamate Lysine Serine (Selenium Cysteine) Arginine Glutamine Leucine Threonine Asparagine Glycine Methionine Tryptophan * Are the vitamins that usually need to Aspartate Histidine Phenylalanine Tyrosine be supplemented. The others should be Cysteine Isoleucine Proline Valine made by the body.
Acupuncture Meridian Beginning and End Point Evaluation
Neurotransmitters
Acetylcholine Noradrenaline
Dopamine Tyramine Serotonin Histamine Taurine Glycine GABA
Aspartate Glutamate
Memory / Learning
Prime Meridian Doctor taps or patient TLs each of the B+E points Without TL to umbilicus, if at least 1 Yin point weakens, there will be at least 1 Yang point that weakens There may not be any positive points without TL to umbilicus TL the positive B+E points with simultaneous TL to the umbilicus will weaken on the primary meridian TL to the primary B+E point will close an open GV 20 and open a closed GV 20
Neurotransmitter Challenge Neurotransmitter Challenge Procedure 1. If more than 1 B+E point weakens (without TL to umbilicus)
a. Identify excess and deficient neurotransmitter b. Identify nutrient(s) that balance neurotransmitter levels
2. If only primary meridian tests positive a. Related neurotransmitter negates TL
1. Determine nutrient(s) needed to make or metabolize neurotransmitter Regulatory Neurotransmitters – Sodium Excitatory Neurotransmitters - CalciumAcetylcholine Aspartate Noradrenaline Glutamate Dopamine Serotonin Inhibitory Neurotransmitters - ChlorideHistamine GABA
Glycine Taurine
If a patient does not TL to any Beginning and End Points, either they are in perfect balance or they are not releasing their neurotransmitters due to the presence of bad fats. Too much emotion / neurotransmitter: Anxiety Too little emotion / neurotransmitter: Depression Diseases Parkinson’s Disease: Low Dopamine, High Acetylcholine.
High ACh is the cause, low dopamine is the effect. Pesticides are the root cause. High ACh will make a person rigid from overfiring the muscles.
Alzheimer’s: Low Acetylcholine Myasthenia Gravis: Low Acetylcholine
Common in dentists due to chronic mercury exposure Difficulty Swallowing
Swallowing is a parasympathetic response. Choline and factors may improve difficulties. Asthma: Low noradrenaline, high histamine Shock: High and low noradrenaline Manic Depression / Bipolar Disorder: High and low Dopamine Migraines: High Serotonin, Excess Tyramine Hot flashes: Low Dopamine Stimulation of the Low Neurotransmitter points can be used to increase the chemical. Stimulation of the High Neurotransmitter points can be used to decrease the chemical. Detoxification Dopamine, Noradrenaline, and Serotonin are ultimately detoxified through Phase 2 by Glutathione, Sulfation, Glucuronidation, and Acetylation. These enzymes can be supported by nutrients or foods. Their conjugates are excreted through urine or bile. Nutrients: Glutathione (Cysteine, Glycine, Glutamate): N-Acetyl Cysteine, Zinc, P5P, Selenium Sulfation (PAPs): Sulfur, MSM
Glucuronidation (UDP Glucuronic Acid): Glucuronate Acetylation (Acetyl CoA): Pantethine (B5), Acetyl CoA (B5) Foods: Glutathione: Spinach, Onion, Garlic, Rosemary, Watercress Sulfation: Dill, Parsnip, Horseradish, Cabbage, Stinging Nettle Glucuronidation: Cashew, Soy, Licorice, Flax, Alfalfa, Jerusalem Artichoke Acetylation: Endive, Pea, Cucumber, Watercress, Tomato In the brain, Glutamate is the main excitatory chemical and GABA is the main inhibitory chemical. In the spinal cord, Aspartate is the main excitatory chemical and Glycine is the main inhibitory chemical.
Acetylcholine Choline Acetyl CoA Choline Acetyltransferase Chemicals – Pesticides, Solanine Thiamin Triphosphate Toxic Metals – Aluminum, Cadmium Manganese Radiation – mobile phones CoA Acetylcholine Acetylcholinesterase
Water Riboflavin
Niacin Manganese
Zinc Pesticides Galantamine Toxic Metals Radiation Acetic Acid + Choline Deficiency of Acetylcholine Excess Acetylcholine Guilt and Blame Pride and Scorn Low NK cell activity (NK cells get rid of tumors) High NK cell activity Tachycardia Aggressive behavior Hypertension Panic attacks (fear paralysis) Dry mouth Bradycardia Poor digestion Hypotension leading to vertigo Constipation Excess salivation Urinary retention Fast transit time, nausea, vomiting, diarrhea Long sight (hypermetropia) Involuntary micturition Glaucoma Asthma from excess mucous Myesthenia gravis Resting tremor and rigidity Hypercholesteroleamia Liver toxicity Inhibition of short term memory Parkinson’s Disease Confusion Delirium Hallucinations Alzheimer’s Diseases Parkinson’s Disease: Low Dopamine, High Acetylcholine
High ACh is the cause, low dopamine is the effect. Pesticides are the root cause. High ACh will make a person rigid from overfiring the muscles.
Alzheimer’s: Low Acetylcholine Myasthenia Gravis: Low Acetylcholine – Common in dentists due to chronic mercury exposure Difficulty Swallowing – Swallowing is a parasympathetic response. Choline and factors may improve difficulties.
Acetylcholine Natural sources of Acetylcholine Limonene - Acetylcholinesterase inhibitor Shepherd’s purse Rosemary Fennel Caraway seed Coriander Black walnut Black pepper Oranges Hawthorn Cardamom Spinach Fennel Carrot Tangerine Fenugreek Spearmint Cardamom Lemon Lime Stinging nettle Corn Natural Acetylcholinesterase Inhibitors – Increase Acetylcholine Galantathine (Galanthamine) found in Snowdrops, Lemon balm, Daffodils Galantathine limits the rate of breaking down acetylcholine so it keeps acetylcholine around longer. Useful in Alzheimers and memory problems. Do not eat snowdrops. Anticholinergics – Block Acetylcholine Solanacea family (contain alpha solanine) (Mandragora officinarum, Atropa belladonna, others) Tomatoes Potato Tobacco Jimsonweed (Thorne apple) Receptors 1. Muscarine receptor (antagonized by atropine) stimulation occurs physiologically when the parasympathetic nervous system is active during rest and sleep.
a. Slows the heart rate b. Stimulates the release of NO in blood vessels vasodilates c. Stimulates the secretion of saliva, mucous, HCl, digestive enzymes, and skin sweat glands d. Stimulates intestinal tone and peristalsis e. Stimulates ureter and bladder contraction f. Stimulates ciliary muscle contraction in the eye causing relaxation of the lens, which is then focused for near vision g. Stimulates contraction of the iris circular muscles causing constriction of the pupil h. Stimulates reduction of the intra ocular pressure by better drainage through Canal of Schlemm
2. Nicotinic (antagonized by curare) receptors occur at a. CNS especially in the hippocampus b. The neuromuscular junctions Acetylcholine is possibly the most widely used neurotransmitter in the body and all axons that leave the central nervous system (for example, those running to skeletal muscle, or to sympathetic or parasympathetic ganglia) use acetylcholine as their neurotransmitter.
Receptor Tests Muscarinic – Patient looks at a bright light and pupils don’t constrict or don’t hold their constriction.
– Patient looks at a bright light and a strong muscle weakens Nicotinic – Sustained muscle test weakens – Hold pressure on a muscle but do not increase pressure. If patient
weakens in under 10 seconds, they have an Acetylcholine deficiency. – If a patient is weak to the sustained muscle test, it suggests that they have poor memory recall because
Acetylcholine is needed to recall memory.
Noradrenaline Phenylalanine H4Biopterin, NADPH, O2 (Iron, B12, Folic Acid) Tyrosine Tyrosine Hydroxylase O2 (Iron, Folic Acid, B12) H4 Biopterin (P5P, Folinic Acid, NADPH, Iron) NADH Vitamin C H2 Biopterin L Dopa Dopamine Decarboxylase P5P Thiamin Pyrophosphate Zinc Magnesium Phosphatidylcholine CO2 (due to hypoxia) Dopamine Dopamine Hydroxylase Copper Vitamin C O2 (Iron, Folic Acid, B12) Noradrenaline Dihydroyphenylacetic Acid + NH2 Monoamine Oxidase Catechol-O-Methyl Transferase Copper Zinc FAD Magnesium O2 SAMe Fe++ Fe+++ O2 Fe++ Fe+++ H2O2 OH- + OH+ H2O2 Dihydroxymandelic Acid + NH2 Homovanillic Acid Catechol-O-Methyl Transferase Magnesium Phase 2 Liver Detoxification SAMe Vanillylmandelic Acid Phase 2 Liver Detoxification
Noradrenaline Diseases Asthma: Low noradrenaline, high histamine Shock: High and low noradrenaline Sources of Noradrenaline Banana Orange Plum Sweet potato Potatoes Deficiency of Noradrenaline Excess Noradrenaline Depression Anxiety Apathy (Sloth) Tremor Low Superoxide production Increased Superoxide Production Lack of “get up and go” Aggressive, Violent, and Impulsive Behavior (nothing right) Hypertension Memory impairment Constipation Dementia Underweight Delusions Palpitations and Tachycardia Delirium Heart Arrhythmias Hypotension Nervous Short sighted (Myopia because can’t dilate pupil) Patient who talks forever but doesn’t say Bronchoconstriction – Asthma anything Small intestine problems – food allergy and intolerance
The Endocrine System
Pineal Gland
Hypothalamus
Pituitary
Thyroid
Adrenals
Steroid Hormones
Endocrine All five senses go to the thalamus, which then sends signals to the hypothalamus to create a hormonal response. Any glandular problem will be secondary to the brain. Hormones can bind to cell surface receptors and stimulate second messengers. Hypothalamus Pituitary Other Glands Somatostatin LH Adrenalin TRH ACTH Calcitonin CRH MSH Glucagon GHRH TSH Parathormone GnRH ADH Insulin PRIH FSH PRL Hormones can also bind to intracellular receptors. Hormones and Brain Chemicals are Related T4 and T3 Estrogens Hormones Neurotransmitters Aldosterone Progesterone Adrenaline Noradrenaline Cortisol Testosterone Estrogen Dopamine DHEA Thyroid Excitation B+E Points and Hormones LU11 High Parathormone? BL67 Low Cortisol GB44 Low DHEA? LI1 Low Parathormone? KI1 High Cortisol LV1 High DHEA? ST45 Low Thymus? CX9 High T4 GV1 High Estrogen SP1 High Thymus? TW1 Low T4 CV1 Low Estrogen HT9 High Adrenalin SI1 Low Adrenalin
Pineal Gland Reasons for Dysfunction 1. Magnesium deficiency leading to calcification 2. Cranial faults causing mechanical inhibition The pineal gland does not secrete hormones into the blood. It secretes into the extracellular fluid that bathes the brain, having a calming effect. Pineal Hormones Serotonin – precursor to melatonin Epithalamin – determines to what age a woman menstruates Vasopressin (ADH) – conserves water in the body Somatostatin Dopamine Melatonin – calms the brain TRH Prolactin Noradrenaline GnRH Pinoline – dreaming; has receptors in the eyes; stimulated by violet Dimethyl Tryptamine – dreaming; has receptors in the eyes Indications Jet Lag Nightmares Morning Stiffness Natural Sources of Melatonin Bananas Morello cherries Porridge oats Effects of Melatonin Antioxidant against hydroxyl radical Stimulation of Calmodulin for protein synthesis Modulation of steroid hormones Stimulates MAO reducing levels of dopamine, noradrenaline, serotonin, and histamine Low MAO activity increases dopamine, noradrenaline, serotonin, and histamine leading to migraines MAO depends on Copper and Riboflavin
Melatonin is stimulated by violet colored foods Induces relaxation which leads to sleep Inhibits sexual function Differentiates white cells into mature T, B, and NK cells
Pineal Gland Tryptophan
Tryptophan Hydroxylase O2 (Iron, Folic Acid, B12) H4 Biopterin (P5P, Folinic Acid, NADPH, Iron) NADH Vitamin C H2 Biopterin 5-Hydroxytryptophan Decarboxylase P5P Thiamin Pyrophosphate Zinc Magnesium Serotonin N Acetyltransferase Acetyl CoA N Acetyl Serotonin O-Methyltransferase SAMe (Magnesium, Zinc, MethylB12, Methyl H4 Folate) Melatonin Hydroxylase Iron (Fe+++) NADPH + H+ 5-Hydroxymelatonin Sulfation Glucuronidation If the patient strengthens to Melatonin but no nutrients are found, check magnesium as the gland could be calcified.
Diagnostic Entry
Biochemistry 1. Vitamins
2. Spices and Minerals 3. Minerals and Endocrine Dysfunction
4. Tissue Salts 5. Amino Acids
6. Simple Lipids, Inflammation, Complex Lipids 7. Connective Tissue
8. Ammonia and Urea 9. Cholesterol
10. Cardiovascular 11. pH Balance
Toxicity
Biomechanics
(See Preliminary Procedures)
Exercise (See Energy section)
Food Sensitivity / Allergy
Infection
Reactive Oxygen Species Bacteria and Virus
Parasites Fungi
Hypoxia
(See Energy Section)
Energy (see Energy section)
Sleep
Dehydration
Diagnostic Entry EID and BID can be used to identify the cause of any positive TL or weak muscle. It can be tested from strength or from weakness, in either case observing for a change in muscle function (strength to weakness or weakness to strength). Either change is a positive. To identify whether to use Eyes Into Distortion (EID) or Body Into Distortion (BID), use the verbal challenge: “The optimal diagnostic entry into your health status is by (BID, EID)”. Eyes Into Distortion 1. Positive TL (B+E Point, Brain Nuclei, other) 2. Patient looks eyes in different directions (do not move head) 3. Correct all areas that show up first 4. Tap GV 20 for 1 minute or press GV 20 firmly once and release 5. Recheck primary B+E 6. If B+E still weak, check eye directions again 7. Repeat until GV 20 tap or press does not make weakness return Emergency or Symptomatic Care 1. TL to any problem area weakens 2. Hold eyes in different directions until one direction strengthens 3. This indicates the cause of the problem 4. Correct and repeat until the TL is negated Body Into Distortion Patient can turn their head instead of moving their eyes. BID works better in cases of nystagmus. BID is not recommended in cases of neck symptoms or to test for infection (circumduction), hypoxia (up and down), or energy (side to side). Directions and Indications Left and Up – Biochemistry / Nutritional Deficiency Left Straight– Toxicity (metals, chemical, radiation) Left and Down – Biomechanical Right and Up – Dehydration Right Straight – Exercise Right and Down – Offending food or drink Clockwise or Counterclockwise – Infection (bacteria, virus, post virus, parasite, fungus, yeast) Up-Down several times – Hypoxia Left-Right several times – Energy / ATP Eyes converge on nose – Sleep (too little or too much) It is possible that Nutrient deficiency does not show up but Hypoxia (or something else) does and needs a nutrient to correct. It doesn’t matter, just fix what shows up. Habituation Often, patients will avoid looking towards a direction that will cause a weakness. It can be helpful to accurately identify causes of dysfunction by “training” the patient to look in each direction. Starting from the middle – above the patient’s nose and with their eyes in neutral position, doctor instructs the patient to follow his finger from neutral to direction being tested and back to neutral. On the 3rd time that the patient moves their eyes, instruct them to hold their eyes in that position (which will be the EID being challenged).
Water Soluble Vitamins B Vitamins with a number are essential. They must come from the diet because the body cannot make them. Nonessential B Vitamins can be made in the body and do not have a number. B vitamins are water soluble and so are not stored in the body. Because of this, they must be ingested every day to prevent deficiencies. Thiamin / B1 / Aneurine RDA: 0.2mg 0-6 months, 0.3mg 7-12 months, 0.5mg 1-3 years, 0.6mg 4-8 years, 0.9mg 9-13 years, 1.2mg male 1mg female 14-18 years, 1.2mg male 1.1mg female 19+ years, 1.4mg pregnancy, 1.4mg breastfeeding DV: 1.5mg UL: None Function: Energy production (CAC), Nucleic acid (Pentose Phosphate) Deficiency: Dry Beriberi (peripheral neuropathy, burning feet, increased reflexes, decreased sensation, weakness of extremities, seizures), Wet beriberi (neurological symptoms, rapid heart rate, enlarged heart, edema, difficulty breathing, congestive heart failure), Cerebral Beriberi (Wernicke’s disease (abnormal eye movements, abnormal posture and gait)), Korsakoff's psychosis (amnesia) Toxicity: None Drug Interaction: Diuretics deplete B1. Phenytoin reduces B1. 5-Flourouracil blocks B1 activation. Nutrient Interaction: Coffee and Tea inactivate B1. Alcohol and caffeine increase B1 excretion. Optimal Food: Wheat germ (4.47mg/cup), Lentils (0.34mg/cup) Solubility: Water Active Form: Thiamin Monophosphate (TMP), Thiamin Pyro/Di phosphate (TPP), Thiamin Triphosphate (TTP) ATP, Mg ATP, Mg ATP, Mg Thiamin Diphosphotransferase Thiamin Diphosphotransferase Thiamin ATP Phosphotransferase Thiamin TMP TPP TTP Riboflavin / B2 RDA: 0.3mg 0-6 months, 0.4mg 7-12 months, 0.5mg 1-3 years, 0.6mg 4-8 years, 0.9mg 9-13 years, 1.3mg male 1mg female 14-18 years, 1.3mg male 1.1mg female 19+ years, 1.4mg pregnancy, 1.6mg breast feeding DV: 1.7mg UL: None Function: Oxidation (lose electrons) and Reduction (gain electrons), Energy production, Food metabolism, Detoxification, Antioxidant (Recycles glutathione (GSSG GSH), Metabolizes xanthine to uric acid) Deficiency: Sore throat, Redness and swelling of the lining of the mouth and throat, Cracks or sores on the outside of the lips (cheliosis) and at the corners of the mouth (angular stomatitis), Inflammation and redness of the tongue (magenta tongue), Moist, scaly skin inflammation (seborrheic dermatitis), Formation of blood vessels in the clear covering of the eye (vascularization of the cornea), Normochromic normocytic anemia, May increase risk of pre-eclampsia Toxicity: None Drug Interaction: Phenothiazine derivatives (Chlorpromazine, Tricyclic antidepressants), Quinacrine, Adriamycin inhibit activation of riboflavin. Phenobarbitol destroys riboflavin. Nutrient Interaction: Activates B3, B6, B9. B2 required for iron metabolism. Optimal Food: Cooked Egg (0.27mg), Almonds (0.23mg/oz) Solubility: Water Active Form: Flavin Adenine Dinucleotide (FAD), Flavin Mononucleotide (FMN) Other: 25mg can be absorbed in a single dose, Destroyed by light ATP, Mg, T3, T4 Flavokinase, Chlorpromazine Riboflavin-5-Phosphate ATP, Mg, T3 , T4 Flavin Adenine H2 FADH2 Riboflavin (Flavin Mononucleotide (FMN)) Dinucleotide
Water Soluble Vitamins Niacin / B3 RDA: 2mg 0-6 months, 4mg 7-12 months, 6mg 1-3 years, 8mg 4-8 years, 12mg 9-13 years, 16mg male 14mg female 14+ years, 18mg pregnancy, 17mg breastfeeding DV: 20mg UL: 10mg 0-12 months, 15mg 4-8 years, 20mg 9-13 years, 30mg 14-18 years, 35mg 19+ years Function: Oxidation (lose electrons) and Reduction (gain electrons) Deficiency: Pellagra (dermatitis, diarrhea, dementia, death), Thick, scaly rash where skin is exposed to light, Bright red tongue, Vomiting, Headache, Apathy, Fatigue, Depression, Disorientation, Memory loss Toxicity: Flushing, Itching, Nausea, Vomiting, Liver cell damage (elevated liver enzymes and jaundice; 750mg/day <3 months duration), Transient low blood pressure, Headaches, Decreased insulin sensitivity, Elevated uric acid, Blurred vision (1.5-5g/day) Drug Interaction: Niacin with Lovastatin can cause rhabdomyolysis. Niacin interferes with Sulfinpyrazone. 5-Fluorouracil and Isoniazid can cause Pellagra. Estrogen increases Niacin synthesis from Tryptophan. Nutrient Interaction: Can be made from tryptophan (60mg TRP 1mg Niacin) Optimal Food: Tuna (11.3mg/3oz), Peanuts (3.8mg/oz) Solubility: Water Tryptophan Formylkyenurinine Kynurenine 3-Hydroxykynurenine P5P
PP-Ribose-P Nicotinate Mononucleotide Nicotinic Acid / Niacin 3-Hydroxyanthranate ATP Nicotinamide / Niacinamide
PP-Ribose-P Nicotinamide Mononucleotide NADH Nicotinate Adenine Dinucleotide / ATP Desamido NAD ATP, Glutamine ATP, Mg Nicotinamide Adenine Dinucleotide (NAD) NADP NADPH Pantothenic Acid / B5 RDA: Not established AI: 1.7mg 0-6 months, 1.8mg 7-12 months, 2mg 1-3 years, 3mg 4-8 years, 4mg 9-13 years, 5mg 14+ years, 6mg pregnancy, 7mg breastfeeding DV: 10mg UL: None Function: Generate energy from food, Synthesis of hormones, neurotransmitters, hemoglobin, Detoxification Deficiency: Headache, Fatigue, Insomnia, Intestinal disturbances, Numbness and tingling of hands and feet Toxicity: Diarrhea (10-20g) Drug Interaction: Oral contraceptives increase requirement for B5. B5 with statins or niacin can have additive effects on lipids. Nutrient Interaction: None Optimal Food: Yogurt (1.35mg/8oz), California Avocado (1.99mg/1 whole), Chicken (0.98mg/3oz) Solubility: Water Active Form: Coenzyme A ATP, Mg ATP, Cysteine Pantothenic Acid 4-Phospho Pantothenic Acid 4-Phosphopantothenyl Cysteine P5P Mg, ATP Mg, ATP
Coenzyme A Dephospho Coenzyme A 4-Phospho Pantethine
Water Soluble Vitamins Pyridoxine / B6 RDA: 0.1mg 0-6 months, 0.3mg 7-12 months, 0.5mg 1-3 years, 0.6mg 4-8 years, 1mg 9-13 years, 1.3mg male 1.2mg female 14-18 years, 1.3mg 19+ years, 1.7mg male 1.5mg female 51+ years, 1.9mg pregnancy, 2mg breastfeeding DV: 2mg UL: 30mg 1-3 years, 40mg 4-8 years, 60mg 9-13 years, 80mg 14-18 years, 100mg 19+ years Function: Neurotransmitter production, Blood sugar maintenance, Red blood cell formation, Niacin activation, Hormone function (decreases), Nucleic acid synthesis Deficiency: Depression, Confusion, Inflammation of the tongue, Sores or ulcers of the mouth, Ulcers of the skin at the corners of the mouth, High homocysteine Toxicity: 1000mg+/day. Neuropathy (Pain and numbness of the extremities, Difficulty walking) Drug Interaction: Isoniazid, Cycloserine, Penicillamine, L-dopa bind with vitamin B6. High doses of B6 reduce effectiveness of phenobarbital, phenytoin, L-dopa. Nutrient Interaction: None Optimal Food: Baked potato with skin (0.70mg), Banana (0.43mg) Solubility: Water Active Form: Pyridoxal-5-Phosphate Pyridoxal ATP, Mg, Zinc Mg, Zn, ATP
Isoniazid, Renal Failure FMN Pyridoxine Pyridoxine-5-Phosphate Pyridoxal-5-Phosphate Pyridoxamine Pyridoxamine-5-Phosphate Folic Acid / B9 DFE: 65mcg 0-6 months, 80 mcg 7-12 months, 150 mcg 1-3 years, 200 mcg 4-8 years, 300 mcg 9-13 years, 400 mcg 14+ years, 600 mcg pregnancy, 500 mcg breastfeeding
1 mcg of food folate = 1 mcg of DFE 1 mcg of folic acid taken with meals or as fortified food = 1.7 mcg of DFE 1 mcg of folic acid supplement on an empty stomach = 2 mcg of DFE
DV: 0.4mg UL: 300mcg 1-3 years, 400mcg 4-8 years, 600mcg 9-13 years, 800mcg 14-18 years, 1000mcg 19+ years Function: One carbon transfer (Methyl CH3, Methylene CH2, Formyl CHO, Formimino CHNH, Methenyl CH), DNA synthesis, Amino acid metabolism Deficiency: Elevated homocysteine, Megaloblastic anemia, Hypersegmented neutrophils, Fatigue, Weakness, Shortness of breath Toxicity: None but supplementing with Folate can reduce the symptoms of a B12 deficiency thereby hiding it and leading to B12 deficiency symptoms, the worst being Subacute Combined Degeneration of the Spinal Cord Drug Interaction: NSAIDs (high dose) interfere with folate metabolism. Anticonvulsants (Phenytoin, Phenobarbital, Primidone) and Cholesterol-lowering agents (cholestyramine, colestipol) inhibit folate absorption. Methotrexate blocks folate activation. Trimethoprim (antibiotic), Pyrimethamine (antimalarial), Triamterene (blood pressure), and Sulfasalazine (ulcerative colitis) antagonize folate. Nutrient Interaction: Works with B12. Optimal Food: Spinach (134mcg/0.5cup), Lentils (179mcg/0.5cup), Cabbage is the only food that muscle tests Solubility: Water B12, Homocysteine NADPH, Vit C NADPH, Vit C Toxic Metals Toxic Metals P5P, Lipoic acid, Methotrexate Methotrexate Mn, B12, Serine NADPH, FAD Folic Acid H2 Folate H4Folate Methylene Folate Methyl Glycine Folate Formate NADPH NADP ATP H2O NH4 10Formyl H4 Folate Methenyl H4 Folate 5Formimino H4 Folate H2O Folinic Acid (5-Formyl H4 Folate) Methylene H4 Folate Deoxyuridylate (dUMP) Deoxythymidylate (dTMP) + H2 Folate
Complex Lipids Phospholipids Nutrients for phospholipids Phosphatidic Acid and Phosphatidylglycerols Acetyl CoA (Vit B5) Phosphatidyl Choline NAD, NADPH (Vit B3) Phosphatidyl Ethanolamine Magnesium Phosphatidyl Inositol Zinc Phosphatidyl Serine SAM (Mg, P5P, Folates, B12) Lysophospholipids Choline Plasmalogens Ethanolamine Sphingomyelins Serine Inositol Cytidine Uridine Saturated fatty acids C16-18 Unsaturated fatty acids C18-24 PAPs Myelin Included when mature: Eliminated when mature: Basic protein and proteolipid High molecular weight proteins Phospholipids and Plasmalogens Desmosterol Sphingomyelins Polysialo gangliosides Glycospingolipids (GM1) Deacylation-reacylation becomes active Cholesterol Glycosphingolipids Cerebrosides Kerasin Cerebron Nervon Oxynervon Sulfatides Gangliosides GM1 (highest), GM2, GM3 Ganglioside GM1 1. Restores dopaminergic neurons after damage to nigro-striatal system, enhances uptake of dopamine and activity of tyrosine hydroxylase 2. Restores cholinergic neurons after damage to the hippocampus, enhances activity of choline acetyl transferase and acetylcholinesterase 3. Restores high-affinity uptake of choline in the cortex after injuries of the forebrain 4. Protects serotonin and noradrenergic neurons from neurotoxin-induced degeneration 5. Diminishes cerebral edema and restores ionic balance after cerebral traumas 6. Stimulates regeneration of the optic nerve 7. Possibly restores melatonin uptake Lipoproteins See Cholesterol
Phospholipids Glycerol ATP Mg
Glycerol-3-Phosphate
(Phosphatidyl Glycerol) NADPH O2 Phosphatidate Dihydroxyacetone
Phosphate H2O Acyl CoA CTP Plasmalogens Cardiolipin Glycerol-3-P Diacylglyerol CDP Diacylglycerol CDP Choline Inositol Phosphatidylinositol CDP- Ethanolamine ATP CH3 (SAM) Phosphatidylethanolamine Phosphatidylcholine Phosphatidylinositol-4-Phosphate Serine ATP Phosphatidylserine Phosphatidylinositol-
4,5-Bisphosphate
Sphingomyelins Coenzyme A + Palmitic Acid P5P, Mn NADPH
Palmitoyle CoA + Serine 3-Ketosphinganine Dihydrosphingosine P5P Mg Zn Acyl CoA
Dihydroceramide Palmitic Acid + Sphingosine CDP
Choline Sphingosine
P5P Phosphorylcholine
Acyl CoA Phosphatidylcholine Ceramide Sphingomyelin
Glycosphingolipids (Cerebrosides)
UDP Glucose UDP Galactose
Glucosylceramide Galactosylceramide(1/4 of all myelin) (Galactocerebrosides) Saccharides (UDP Glucose, PAPS
UDP Galactose, UDP Galactosamine, N Acetyl Neuramic Acid) Gangliosides Sulfatides (rich in myelin)
Gangliosides: GM3 – Ceramide + Glucose + Galactose + N Acetyl Neuraminic Acid GM2 – GM3 + N Acetyl Galactosamine GM1 – GM2 + Galactose S-Adenosyl Methionine (SAM) methylates the last step in myelin synthesis.
Toxicity Eyes or head straight left Phase 1 Detoxification Challenge Procedure 1. Positive TL to (Liver) B+E point is negated by Chemical, Toxic Metal, or Radiation 2. Chemical, Toxic Metal, or Radiation weakens 3. If Cytochrome P450 enzymes strengthen
a. Test nutrients: Phosphatidylcholine, B3 (NADPH, NAD) , Magnesium, Iron, B2 (FMN, FAD), Alpha Lipoic Acid, Broccoli (1A2), Brussel Sprouts (1A2), St John’s Wort (3A4, 5, 7), Licorice, Black Walnut, High protein, low carbohydrate, ethanol (2E1), Zinc, Copper, Chromium, Calcium, Molybdenum, Selenium, Vitamin E, Vitamin C, Bioflavonoids, Beta Carotene, Nutrient Phase 1+2
4. Patient weakens to a CYP suggests increased Phase 1, Free radicals, and decreased phase 2 a. Test antioxidants b. Improve phase 2 detoxification to reduce the load on phase 1
Phase 2 Detoxification Challenge Procedure 1. Positive TL to (Liver) B+E point is negated by Chemical, Toxic Metal, Radiation 2. Patient weakens to one or more Cytochrome P450 enzymes 3. Positive TL to (Liver) B+E point or weakness from CYP450 is negated by one or more of
Glutathione-S-Transferase, Glucuronic acid, PAPS, Sulfite Oxidase, Acetyl CoA, SAM, Taurine, Threonine, Glycine, Cysteine
4. Test nutrients related to strengthening substance (chart below) 5. Identify offending chemical and source (radiation, toxic metal, pesticide, alcohol, solanine, other chemical) 6. Identify any additional detoxification substances 7. Supplement appropriately 8. Avoid offending chemical Amalgam Challenge Procedure 1. Caffeine or Acetic Acid causes positive TL to a filled tooth 2. Indicates that tooth is leaking metal Conjugate Challenge Substance Biomarker (tester) Nutrients XOH+Glutathione Acetominophen Glut-S-Transferase Glutathione (NAD, GLU, Lycine, B6, Zn) XOH+Glucuronidation Aspirin Glucuronic Acid Glucuronic Acid XOH+Sulfation Acetone PAPS PAPS, S, MSM, Lipoic Acid, GlucosamineSO4 Sulfite Oxidase Sodium Metabisulfite Sulfite Oxidase Mo, Fe XOH+Acetylation Newsprint, Petrol Acetyl CoA Acetyl CoA (B5, Mg, Acetic Acid) XOH+Methylation RNA, Caffeine SAM Methionine, Mg, B12, Folate, Betaine, DMG XOH+Taurine Pesticides Taurine Taurine, NAD, Vitamin C, Vitamin A XOH+Threonine Threonine Threonine XOH+Glycine Sodium Benzoate Glycine Glycine, B6, B2, Mg, Folate XOH+Cysteine Citric Acid Cysteine Cysteine, NAD, Methionine, B6, Mg, Vit C Endogenous Exogenous Endogenous and exogenous chemicals Neurotransmitters Water soluble xenobiotics are detoxified through the same pathways. Hormones Lipid soluble xenobiotics Eicosanoids Certain fatty acids Retinoids The purpose of detoxification is to make the chemicals water soluble. A dysbiosis will cause conjugated toxins to be deconjugated and reabsorbed, preventing the toxin from leaving the body. Impaired estrogen excretion is a cause of weight gain. The major water soluble toxin that the bladder and kidney pass out is toxic metals. 50% of prescribed medications are metabolized by CYP enzymes. Many CYP enzymes are inhibited by drugs, causing drug interactions.
Detoxification – Phase 1 Hydroxylation by Cytochrone P450 There are 14 families of the Cytochrome P450 enzyme encoding for between 35-60 distinct P450 enzymes. They all use the abbreviated root symbol CYP. This is followed by a number designating the family having similar sequence identity. This is followed by a capital letter indicating the subfamily. Lastly, this is followed by another number indicating the individual P450s in the family. Example: CYP1A1. CYP1A1 2-Estrogens, Polycyclic Aromatic Hydrocarbons (PAHs) (benzopyrene from chargrilling) CYP1A2 16-Estrogens, Uroporphyrinogen (heme)
Induced by smoking, broccoli, sprouts, chargrilling, high insulin, pesticides High in colon cancer
CYP1B1 4-Estrogens, Synthetic estrogens (Hormone Replacement Therapy, Oral Contraceptive Pills) Linked to Glaucoma, malignancy CYP2A6 Nicotine CYP2B4 Phenobarbitol, Induced by Butylated Hydroxytoluene (BHT) CYP2C9 Warfarin, NSAIDs, Fluvastatin, Tamoxifen, Amitryptyline Inhibited by St Johns Wort, Induced by Thiol Pesticides CYP2C19 Antidepressants, Antipsychotics, Diazepan, 30% of drugs with 2D6 Inhibited by St Johns Wort, Induced by Thiol Pesticides CYP2D6 Antidepressants, Antipsychotics, Codeine, Organophosphate Pesticides, 30% of drugs with 2C19 Induced by Thiol Pesticides CYP2E1 Ethanol, Solvents, Acetomenophen, Tobacco smoke CYP3A4 50% of Pharmaceutical Drugs, Lidocaine, Lovastatin, Taxol, Warfarin, Organophosphate Pesticide
Induced by St Johns Wort, Orange Juice, Thiol Pesticides, Inhibited by grapefruit The cytochrome P450 vials can strengthen, indicating a need to upregulat phase 1. They can also weaken, indicating that phase 1 is moving too fast and phase 2 can’t keep up. This produces toxic intermediates and indicates a need to upregulate phase 2 Silymarin Flavonoids extracted from Silybum marianum / Milk Thistle Protects liver from damage and enhances detoxification Antioxidant – more potent than vitamins E or C Increases synthesis of Glutathione by 35% Prevents depletion of glutathione caused by alcohol and other toxic chemicals Increases rate of liver tissue regeneration Protects the liver from damage caused by carbon tetrachloride, amanita toxin, galactosamine, praseodymium nitrate Scale of Toxicity “On a scale of 1 to 1000, with 1000 being no toxicity and 1 being completely toxic, your scale of toxicity right now calibrates at _____.” Scale of Homeostasis “On a scale of 1-1000 with 1000 being perfection (for you) your scale of homeostasis right now calibrates at ___” When Homeostasis is high and toxicity is high (meaning very toxic, low on the scale) this indicates that the patient is doing something beneficial but it is doing a “holding job” and if removed the patient will feel worse. The toxicity must be addressed.
Detoxification – Phase 2 Glutathione (Cysteine, Glutamic acid, Glycine linked by P5P, ATP(Mg)) Detoxifies – Xenobiotics (exogenous chemicals), Naphthalene, Phenanthacin compounds, Aliphatic disulphides Nutrients – Zinc, Selenium-Cysteine, NADPH, Glutathione-S-Transferase, NAC, Vit C 500mg/day, Silymarin, Glycine, Methionine, B2, B6, B12, Magnesium, Copper, Cysteine, Glutamate, EFAs, Indole-3-Carbinol Foods – Spinach, Onion, Garlic, Broccoli, Lemongrass, Celery, Rosemary, Watercress, Turmeric, Pomegranate, Sulfurophanes, Cruciferous Vegetables, Limonene foods (citrus peel, dill seed oil, caraway oil) Glucuronidation Detoxifies – Neurotransmitters, Hormones, Phenol, Benzoic Acid, Vanillin, Alcohol, Enol, Carboxylic Acid, Amines, Hydroxyamines, Carbamides, Sulphamides, Thiols, Phenobarbitol Nutrients – Glucuronic Acid, Magnesium, NAD, EFAs, Foods – Artichokes, Cashew, Soy, Licorice, Flax, Alfalfa, Calcium d-Glucarate foods (Oranges, Apples, Grapefruit, Cruciferous Veg) Sulfation Detoxifies – Neurotransmitters, Hormones (steroid and thyroid), Acetone, DDT/DDE, Ethylene glycol, Fluorine, Toluene, TRIC, Cyanide, Acetomenophen, Aliphatic Alcohols, Aryl Amines, Alicyclic Hydroxysteroids Nutrients –Sulfur (PAPS, MSM, SAM), Alpha Lipoic Acid, Cysteine (Methionine, MethylB12, Folate, Mg, B6), Molybdenum, B2, Manganese Foods – Broccoli, Asparagus, Garlic, Mustard, Dill, Parsnip, Horseradish, Cabbage, Sting Nettle, Cruciferous Veg Sulfoxidation Detoxifies – Sodium Metabisulfite Nutrients – Molybdenum, Iron Acetylation Detoxifies – Isoniazid, Gasoline, Petrochemical byproducts (makeups), Newsprint (arsenic, lead), Hypochlorite, Aromatic amines (histamine, serotonin), Aspirin, PABA, Sulfur amides, Aliphatic amines, Complex hydrazines Nutrients – Pantethine, Acetyl L Carnitine, NAD, FAD, Molybdenum, Iron, Acetyl CoA Factors (P5P, Cysteine, Magnesium, Vitamin C) Foods – Endive, Pea, Cucumber, Watercress, Tomato Symptoms – Long vision (can’t see close up), Poor memory, Low immunity (low T cell), Slow peristalsis, GI symptoms, Weak sustained muscle strength, Low CAC, Fatigue, Weight gain (low B-Ox), Sleep problems (low melatonin), Joint pain, Hypertension, Trigger points (high ADP) Methylation Detoxifies – Estrogens, Caffeine, Amines, Phenols, Thiols, Noradrenaline, Adrenaline, Dopamine, Melatonin, L-Dopa, Histamine, Serotonin, Pyridine, Sulphites, Hypochlorites, Heavy metals Nutrients – SAM, Methionine (Magnesium, Zinc, ATP, 5MTHF, MethylB12), Methyl Donors (Choline, Betaine, DMG), L. acidophilus to make Choline Other – Methionine promotes flow of lipids to and from the liver, SAM must be supplemented in liver damage, SAM prevents estrogen induced cholestasis Amino Acids Taurine – Agricultural chemicals, Carbon Tetrachloride, Cholyl CoA
Locations – Brain (glial cells), Eyes (choroids), Heart (arrhythmias), Bile salt synthesis Nutrients – MET, CYS, B3, Iron, Mg, Zn, Cu, P5P, B9, MethylB12, CH3 donors
Glycine – Detoxifies – Sodium Benzoate, Aspirin, Cholyl CoA, Toluene, Salicylates Nutrients – Glycine (Folate, P5P, Mg, Zn, B2, B3), Mn, FAD, NAD, Arginine, Arginase, CH3 donors People with hepatitis, alcoholic liver, carcinoma, chronic arthritis, hypothyroid, toxemia of pregnancy, excess chemical exposure have poor glycine conjugation
Cysteine (eczema) – Nutrients – Methionine, Folate, B6, MethylB12, CH3 Threonine (for glycine) Glutamine – gut Tryptophan – fungal toxins
Infectious Diseases Eyes in a circle clockwise or counterclockwise Wake up with nausea = parasites Nauseous after eating = allergy Use herbs as medicines when the patient is ill. Use herbal tinctures for systemic illness. Use herbal capsules for a gut infection or gut parasite. Nonspecific Immune System Works all the time; Engulfs foreign objects and kills them with enzymes and free radicals White Blood Cell Neurotransmitter Pathogen Free Radical Granulocytes Neutrophils Noradrenaline Gram + Bacteria, Virus Hypo Cl, Br, I* Eosonophils Inhibitory Parasites, Bacteria H2O2 Basophils / Mast Cells Histamine Allergen Histamine Agranulocytes Monocytes / Macrophages Dopamine Gram - Bacteria Nitric Oxide Cytokines and Interleukins tell the Specific Immune System that the Nonspecific Immune System is having trouble. *Green = Bromide, Red = Iodide, Blue = Chloride Specific Immune System Activates after a couple days of an unresolved infection White Blood Cell Neurotransmitter Function Lymphocytes B Lymphocytes Serotonin Marks with Antibodies (Igs) T Lymphocytes Acetylcholine Kill microorganisms Helper Hold the organisms in place Memory Remember infections Killer Kill microorganisms Suppressor Stop the killing Natural Killers Excitatory B Lymphocytes put a “hat” on the substance that is to be eliminated. The hat is called an Antibody or an Immunoglobulin. The Immunoglobulins are G, A, M, E, and D. The targeted substance could be a virus, bacteria, or a protein from a food. This hat is a marker for the T Lymphocytes to eliminate that substance. Five Chemicals of Inflammation Histamine – vasodilation, reddening, itching Bradykinin – pain Serotonin – systemic vasoconstrictor (except middle meningeal artery) Prostaglandin E2 – blood circulation, some pain Leukotriens – 1000x more inflammatory than histamine, massive tissue destruction, not always pain All five sensitize nociceptors to tell the brain there is tissue damage Defense against virus, bacteria, fungus, toxin: 1st line – neutrophils and macrophages 2nd line – neutrophils 3rd line – macrophages 4th line – neutrophils and macrophages The chemicals that control macrophage and neutrophil response are made by Macrophages and T Cells: TNF, IL 1, GM-CSF, G-CSF, M-CSF Colony Stimulating Factors (CSF) causes marrow to increase production of neutrophils and macrophages for 4th line of defense. See Organ Related Conditions for detailed information on Immune System.
Reactive Oxygen Species Types Reactive Oxygen Species include Superoxide (O2-), Hydrogen Peroxide (H2O2), Hydroxyl (OH-), Hypochlorite (OCl-), Hypobromide (OBr-), Hypoiodide (OI-), Peroxynitrite (ONOO-), Nitric Oxide (NO). OH and ONOO are highly damaging and are not normally made by the body. H2O2 can melt the pancreas and cause Type 1 Diabetes. Production 1. During the Respiratory Burst (increased temperature), membrane bound NAD(P)H Oxidase is activated in both Macrophages and Granulocytes and produces Superoxide Anion radicals from molecular oxygen. 2. Macrophages can also generate NO via the conversion of Arginine mediated by inducible Nitric Oxide Synthase (iNOS). 3. Granulocytes (large amounts in a single shot), and Macrophages (small amounts but more constant), discharge the lysosomal enzyme Myeloperoxidase stimulating halogen anions. Functions: Kill invading pathogens, Promote cell growth, Promote cell division Reactive Oxygen Specie Organism Killed Hydrogen Peroxide Parasites, Gram + Bacteria, Acute Virus Hypo Chlorite, Bromide, Iodide Gram Positive Bacteria, Acute Viruses (Herpes, Hepatitis) Nitric Oxide Fungus, Gram Negative Bacteria, Acute Virus Peroxynitrite Post Viruses, Systemic Fungal infections To test for: Use vials: 1. Superoxide Anion Superoxide + NADPH + Fe 2. Hydrogen Peroxide Hydrogen Peroxide 3. Glutathione Peroxidase Glutathione Peroxidae 4. NADH Peroxidase NADH Peroxidase 5. Peroxidase Peroxidase 6. Catalase Catalase 7. Hypochlorite anion Hydrogen Peroxide + KCl or MgCl2 8. Hypobromite anion Hydrogen Peroxide + KBr or MgBr2 9. Hypoiodite anion Hydrogen Peroxide + KI or MgI2 10. Hydroxyl Radical Superoxide + NADPH + Fe + Hydrogen Peroxide 11. Nitric Oxide Nitric Oxide 12. Peroxynitrite Nitric Oxide + Superoxide + NADH + Fe 13. Singlet Oxygen Hydrogen Peroxide + Hypochlorite Challenge for Excessive Reactive Oxygen Species 1. Patient’s weakening acetate + oxygen together weaken 2. Check for strengthening against Vitamin A, Carotenoids, Lycopene, Alpha Lipoic Acid, Vitamin C, Vitamin E, CoQ10, Evening Primrose Oil, Sesame Seed Oil, Anti Aging Products (AA Capsules, AA Phospholipid complex, AA Cream)
Bacteria Bacterial Infection Challenge Procedure Diagnosis: 1. TL to lymph node, B+E point, sore throat, or other area of inflammation weakens – negated by Bacteria 2. Bacteria weakens in the clear Treatment: 1. Catalase weakens Gram Positive Bacteria
a. Superoxide Anion strengthens (Superoxide+NADPH+Fe) – Heating Spice to increase Respiratory Burst 1. Red – Ginger 2. Green – Turmeric or Cardamom 3. Blue – Mustard or Nutmeg
b. Hydrogen Peroxide strengthens Zinc, Copper, Manganese, Iron
c. Myeloperoxidase strengthens Ionic Silver, Gold, Platinum d. Test Halogen related to weakening color 1. Red – Hypoiodite (H2O2+KI or MgI) a. Black Walnut – MgI b. Non-Stinging Stinging Nettle – KI c. Kelp – Iodine 2. Green – Hypobromite Anion (H2O2+KBr or MgBr) a. Walnuts 3. Blue – Hypochlorite Anion (H2O2+KCl or MgCl) a. Low Sodium Salts 2. Nitric Oxide strengthens Gram Negative Bacteria Arginine, Zinc, Zinc Arginate, NADPH, Iron, Vitamin C, Ionic Molybdenum 3. Peroxynitrite (NO+Superoxide+NADH+Fe) strengthens Gram Negative Bacteria (chronic)
Selenium, Ionic Molybdenum, Iron, Copper 4. Challenge with antibacterial substances
Ionic silver Ionic molybdenum Essiac formula tinc Hoxsey formula tinc Immune formula tinc Echinacea tincture Ginger tincture Turmeric tincture Mustard tincture Mouthwash Red Clover tincture Phytogen caps
SF734 caps (upper gut) Undecyne caps (lower gut) Uristatin caps (GU) Capsicum caps Ginger caps Turmeric caps Mustard caps Mannose Fresh sheep sorrel (Rumex acetosella) Burdock root (Articum lappa)
Turkey rhubarb (Rhuem palmatum) Slippery elm (Ulmus rubra) Watercress Red clover (Trifolium pratense) Black walnut (Juglans nigra) Immune WHY 600 (Gram -) Astragulus (virus) Uva Ursi (GU tract) Waltheria tincture (Strep)
5. Test saccharides for strengthening Fucose, Galactose, Glucosamine, Glucose, Glucuronic Acid, Mannose, Xylose, N Acetyl D Glucosamine, N Acetyl Neuraminic Acid, N Acetyl Galactosamine
6. Test individual probiotics for strengthening 7. Supplement with indicated nutrients Acute Infections – take exact dose every 2 hours Chronic Infection – take exact dose 1-3 times per day Silver Cream is to be applied locally on the skin 3-4 times a day (ex. on the throat in a sore throat) To take heating spice, dilute dose in cup of water and drink all at once. Refill and sip for 2 hours. Keep sipping all day to keep level of spice high. Shock Dose for a beginning infection (won’t work in a Gram Negative infection) 30ml bottle of ionic calcium – drink the whole thing to alkalize the body 20 mins later – mix together and drink 30 ml 300ppm ionic zinc, 30 ml ionic copper, 30 ml ionic silver
Bacteria - Classification Aerobes Gram positive (* Sensitive to ionic silver) Cocci
Micrococcus* M. luteus (skin) M. roseus (skin) M. varians (skin)
Staphylococcus* S. aureus (skin; food poisoning)
Non-aureus S. epidermis (skin) Streptococcus (throat, cystitis)
Group A S. pyogenes (throat) Group B S. agalactiae (GUT) Group C Group D S. faecalis (GUT)
S. faecium (GUT) S. durans S. avium S bovis
Group F Group G
S. pneumoniae (lungs) (Pneumoccus) S. mutans (tooth decay) (Viridans) S. mitis (mouth)
Bacilli Bacillus* B. anthracis (anthrax)
B. cereus (GUT) Lactobacillus L. acidophilus etc (GUT) Listeria* L. monocytogenes (GUT)
L. ivanovii (septeceamia) Erysipothrix E. rhusiopathiae (skin) Corynebacterium* C. diptheriae (diptheria)
Gram negative Cocci
Neisseria* N. gonorrhoeae (genitals) N. meningitides (meningitis)
Enterobacteria Escherichia Coli E. coli (GUT) Shigella S. dysenteriae (GUT)
S. flexneri (GUT) S. boydii (GUT) S. sonnei (GUT)
Edwardsiella E. tarda (GUT) Salmonella S. typhimurium (GUT) (slow food S. enteritiidis (GUT) poisoning) Citrobacter C. freundii (GUT)
C. diversus (GUT) Klebsiella K. pneumoniae (GUT) Enterobacter E. aerogenes (GUT;
Frozen Shoulder) E. cloacae (GUT)
Serratia S. marcescens (GUT) Proteus P. mirabilis (GUT)
P. vulgaris (GUT) Morganella M. morganii (GUT) Providencia P. alcalfaciens (GUT) Yersinia Y. enterocolitica (GUT)
Y. pestis (plague)
Pleomorphic rods Haemophilus H. influenza (meningitis)
H. aegyptius (conjunctivitis) H. ducreyi (genital ulcers)
Bordetella B. pertussis (whooping cough)
B. parapertussis (meningitis) B. bronchiseptica (pneumonia)
Brucella B. arbortus (cattle) (Brucellosis) B. suis (swine)
B. meltensis (goat) B. canis (dog)
Pasteurella* P. multocida (inflammatory arthritis)
Legionella* L. pneumophilia (pneumonia) L. micdadei (influenza)
Miscellaneous Vibrio * V. choleraea (cholera)
V. parahaemolyticus (diarrhea) V. vulnificus (systemic)
Rods Campylorobacter* C. jejuni (GUT; food
poisoning) Helicobacter* H. pylori (ulcers)
Non fermenters (Cystic Fibrosis) Pseudomonas P. aerginosa (lung) (Burkholderia) B. cepacia (lung) (Stenotrophomonas) S. maltophilia (lung) Acinetobacter A. ivvoffii (meningitis)
A. baumannii (skin) Flavobacterium F.meningosepticum
(meningitis) Acaligenes A. faecalis (GUT)
Anaerobes Gram Positive Bacilli
Clostridium C. tetani (tetanus) (fast acting C. difficile (toxic with food poisoning) antibiotics; ulcerative colitis,
crohns disease) C. perfringens (GUT)
C. botulinum (GUT) (botulism)
Actinomyces A. israelii (abcess) Bifidobacterium B. dentium (toxic with
antibiotics) Eubacterium E. lentum (endocarditis) Proprionibacterium* P.acnes (abcess) Lactobacillus (facultative)
Cocci Peptostreptococcus P.magnus (musculoskeletal)
Gram negative Bacilli
Bacteroides* B. fragilis (GUT) Prevotella Porphyromonas Fusobacterium F. nucleatum (gums)
Cocci Veillonella V. parvula (mouth)
Emotional
Unconscious Emotion
Love Challenge
Psychological Reversal
Pain Body
Love Challenge Love embraces all things Love trusts all things Love transcends all things Love is never possessive Love is never fearful Love is simply love Love cannot shine with any specialness on anyone at any time Love can only be welcomed where love truly resides Love resides within you and the Source of your very being If you would know love, know your Self If love flows through you, it must first flow to you Your work is not to seek and find love. It is to merely turn within to discover every obstacle that you have created to its presence. Procedure 1. After correcting all structural and chemical faults as noted in the protocol 2. Patient weakens to closing their eyes 3. “The optimal emotional correction for me to perform on you is the love challenge” strengthens 4. Patient weakens to saying one of the following:
“I am loved” “I am loving” “I am loveable”
5. Correct by repeating the weakening statement 20 times every night The hardest statement to accept is the doorway to the unconscious emotion. Healing will occur when the patient withdraws all valuation placed on the disease. 1 Corinthians 13:1-15 I may have all the faith needed to move mountains – but if I have no love, I am nothing. I may give away everything I have and even give up my body to be burnt – but if I have no love, this does me no good. I may be able to speak the language of human beings and even of angels, but if I have no love, my speech is no more than a noisy gong or a clanging bell. I may have the gift of inspired preaching, I may have all knowledge and understand all secrets, Love is patient and kind, it is not jealous or conceited or proud. Love is not ill mannered or selfish or irritable, love does not keep a record of wrongs. Love is not happy with evil, but is happy with truth. Love never gives up, and its faith, hope and patience never fail. Love is eternal. Love is patient and kind. Love is happy with truth. Love never gives up, and its faith, hope and patience never fail. Love is eternal. 1. Love is not jealous (Craving and desire) 2. Love is not conceited (Fear and anxiety) 3. Love is not proud (Pride and scorn) 4. Love is not ill mannered (Apathy and despair) 5. Love is not selfish (Shame and humiliation) 6. Love is not irritable (Anger and hate) 7. Love does not keep a record of wrongs (Grief and regret) 8. Love is not happy with evil (Guilt and blame) To create a new neural net, something must be said or done 580 times. Saying the affirmations 20 times a night for 30 nights is 600 times and therefore will hardwire the statement into the brain.
Organ Related Conditions
1. Ear, Nose, Throat, Mouth
2. Genito-Urinary System (Kidney, Prostate, Genitals)
3. Gastrointestinal System
4. Immune System
5. Gout
6. Itch
7. Rheumatoid Arthritis
8. Glaucoma
9. Respiratory Conditions
10. Neurobehavioral Disorders, Tests, Exercises
Ear - Tinnitus Causes Prescription Drugs Anxiety and depression drugs, anti-malarial medication, blood pressure controlling medicines, toxins ingested into the body, and heavy metal poisoning Toxic Metal Poisoning Electrical discharge from mercury fillings in teeth can cause tinnitus. Tinnitus From Auditory Nerve Damage Often confused with outer or middle ear damage. Damage to the ear drum does not mean auditory nerve damage. Chronic Tinnitus At least 10 million Americans suffer from tinnitus so chronic that they are unable to function normally. Tinnitus From Eardrum Damage Most of the problems of the outer ear that can cause tinnitus are usually mechanical in nature. Patulous Eustachian Tubes The normal eustachian tube is functionally collapsed at rest, with slight negative pressure present in the middle ear. It opens during swallowing, sneezing, and yawning. Pulsatile Tinnitus Tinnitus which pulsates in time to the heart beat. This type of tinnitus occurs when there is a narrowing or a partial blockage of arteries. Internal Carotid Artery is the most likely. Remedies Cochlear Damage Remedy 1. Thiosinaminum - a natural chemical that is derived from oil of the mustard seed and is excellent for ringing in the ear. It may also be helpful in tinnitus when the cause is from scar tissue. Helpful with otitis media and deafness due to fibrous change in the nerve. 2. Carboneum Sulphuratum - helps with impaired hearing, a sensation of fullness in the ears, and noises in the head. Will help when the hearing is impaired with buzzing and singing noises like a harp. Successfully treats Tinnitus and Meniere's disease. 3. Chininum Sulphuricum - Sulphite of Quinine - Used in homeopathy to help with buzzing, ringing, and roaring sounds that are loud enough to impair the person’s hearing. Particularly helpful with violent ear ringing, buzzing, and roaring in ears with deafness. 4. Pulsatilla Vulgaris - Pulsatilla belongs to the Buttercup family of flowers, native to western, central and southern Europe. When potentized homeopathically Pulsatilla diminishes acuteness of hearing, relieves inflammation of the Eustachian tubes, and relieves ringing noises in the ears. 5. Cinchona Officinalis - China. Peruvian Bark - Excellent in the relief of sensitivity to noise and tinnitus. Helps ringing in the ears, humming, roaring or ticking in the ears, and hearing problems. Sinus Remedy 1. Hydrastis - Hydrastis canadensis. Golden Seal. Orange-root. Yellow Puccoon. N. O. Ranunculaceæ. Tincture of the fresh root. Very effective in relieving blockage of the eustachian tubes. 2. Calcarea Carbonica 3. Kalium Bichromate - Potassæ bichromas. Potassic dichromate. Bichromate of Potash. Red Chromate of Potash. K2Cr2O7. Solution in distilled water. This is one of the most valuable remedies in homeopathy that treats sinusitis. Very effective in treating ulcerations of the nasal mucosa. 4. Silicea
Ear - Tinnitus Stress Remedy 1. Phosphoric Acid - H3P04. Dilution. For the relief of stress, nervous tension, and mild anxiety. (The dilute acid of B. P. forms the homeopathic 1x. In The first solution is made of glacial Phosphoric Acid.) 2. Sulphur 6C - Brimstone. Sublimed Sulphur. S. (A. W. 3l.98). Trituration of "Flowers of Sulphur." A saturated solution of Sulphur in absolute alcohol constitutes the Ø tincture. Used in homeopathy for giddiness and flushing, especially on getting out of bed in morning, suffocating feeling, oppressive, burning sensation in chest, suddenly becoming hot and flushed in the face. 3. Sepia 6C - Sepia officinalis. Cuttle Fish. N. O. Cephalopoda. Trituration of dried liquid contained in the ink-bag. Relieves irritibilty, bottled up anger, despair, fear that something dreadful is about to happen, nervous tension, and anxiety. 4. Calcarea Carbonica 12C - Impure Calcium Carbonate. Ca C03. Including symptoms of Calcarea acetica and Calcarea ostrearum, a trituration of the middle layer of oyster shells. Helps with inflammation of the sinuses and nose. Relieves inflamed sinuses. Often used in homeopathy to treat symptoms of exhaustion, depression, and anxiety. 5. Silicea 12C - Silicea terra. Pure Flint. Silex. Silicic anhydride. Silicon dioxide. SiO2. Trituration of pure, precipitated Silica. Silica is essential for growth and bone development, is present in connective tissue, and helps to keep cartilage flexible and skin permeable. Used extensively to control vertigo with nausea, fainting, and also vertigo creeping up the spine into the head. Effective with chronic headache attended with nausea and vomiting. 6. Kali Phos 3C - Phosphate of Potassium. K2HP04. Trituration. Solution in distilled water. Helps with feeling scared, unhappy, irritable, worried about one's future, sense of failure, forgetfulness, nervousness, feeling overwhelmed when alone, sensation of bed sinking into floor as one falls asleep. Tinnitus & Meniere's Disease Remedies 1. Thiosinaminum 2. Carboneum Sulphuratum 3. Chininum Sulphuricum 4. Pulsatilla Vulgaris 5. Cinchona Officinalis 6. Belladonna - Belladonna, more commonly known as deadly night-shade. Is very helpful in treating giddiness, confusion, excitation, incoherent or violent behaviour, motion sickness, and vertigo associated with Meniere's disease. 7. Calcarea Carbonica 8. Silicea
Ear - General Wax Olive oil and juniper oil – 2 drops in each ear twice a day to soften the wax Hydrogen Peroxide (3%) Wax softening drops Syringe Itch Caused by: Eczema Psoriasis Waterlogged Allergy – dairy products, can be goat, sheep, soy Parasites – nematodes synthesize toluene which comes out in the wax and causes itching Chemical toxicity
Toxic metal – usually mercury Emotional – habitual scratching, emotional reasons to scratch ears, other deeper problems Treatments: Antibiotic drops – H2O2, Ionic Silver Cleaned by specialist
Otitis Externa Otitis Media Swimmers Ear Severe earache Inflammation behind eardrum Tympanosclerosis Calcium deposits on drum Central Perforation of the Drum Need magnesium Secretory Otitis Media / Glue Ear Vertigo Needs Iodine See The 5 Senses
Ear - Deafness Hereditary Congenital Deafness Alport’s Syndrome Associated with blood and albumin in the urine. Can occur during the first week of life. Deafness is sensineural and progressive. Eventually renal failure will occur. Male patients worse affected, usually dying of chronic nephritis before age of 30. Hurler’s Syndrome Associated with 'gargoylism'. Head is enlarged, face flattened, neck short, eyes enlarged and wide apart, teeth widely spaced and abdomen protruding. Is progressive, usually after speech has begun. Results in mental disability and enlarged spleen and liver. Klipell Feil Syndrome Linked with spinal deformity. Usually a missing a vertebrae in the neck. Deafness is usually profound. Pendred's Syndrome Related to a deficiency in the thyroid gland which leads to swelling in the neck. Swelling can usually be treated but the hearing impairment cannot. Cases recorded in which deafness has not started until after age of 4. Treacher Collins Syndrome Results in malformations of the conducting mechanisms of the ear. In an extreme form, the lower jaw and some facial bones to fail develop properly. Deafness is of varying degrees of severity and kinds. Waardenburg's Syndrome Physical characteristics can include a broad nasal bridge, wide spaced eyes, eyes of different colors, a streak of white hair in the middle of the forehead. This type of deafness is always profound. Usher Syndrome Children often born hearing but deafness occurs. It is progressive accompanied by changes in the retina. Many people may believe themselves just to be deaf until they encounter vision difficulties. Can result in complete blindness.
Ear - Deafness Pre-natal Deafness Maternal Rubella 20% of all cases of congenital deafness. The earlier it is contracted in pregnancy, the more damage it will cause. By 4th month neural structures and embryonic cochlea are nearly fully developed. Associated with blindness, heart disease, brain damage, and spasticity. Women need to get Rubella as children so they can pass on their antibodies to their children. Viral Infections Most notably influenza contraction by mother during pregnancy. May account for a small number of cases of congenital deafness. Drugs Thalidomide which has been identified as a cause of deafness as well as limb deformities. Peri-Natal Deafness Kernicturus An incompatibility in the blood groups between mother and baby. Causes damage to the cochlear nerve fibres. Anoxia Lack of oxygen, also associated with brain damage. Other cases include prematurity, birth injury. Post-Natal Deafness Measles Can cause moderate to severe hearing loss. Usually affects both ears. Possible implication in otosclerosis. Mumps Characterised by severe hearing loss in one ear only. Meningitis Controversy over whether deafness is caused as a result of the infection or the drug used to treat it. Drugs (ototoxic deafness) Allergic reaction or toxicity. Cochlea Osteosclerosis Progressive loss usually in both ears. Progression is slow and hearing tends to stay stationary for a long time. Is identified by loss of high tones before low tones. Otosclerosis (hardening) A progressive degenerative condition of the temporal bone which can result in hearing loss. May be fixation of the stapes footplate to the oval window of the cochlea which impairs movement of the stapes and transmission of sound into the inner ear (“ossicular coupling”). The cochlea’s round window can also become sclerotic and in a similar way impair movement of sound pressure waves through the inner ear (“acoustic coupling”). Noise Induced deafness Associated with particular professions where noisy machinery is used. Hearing loss is variable. Head Injuries Deafness can follow injuries to the head such as a skull fracture, concussion, and blast injuries. If hearing loss is due to a 'trauma' it is possible some or all of the hearing may return. Meniere's Disease Associated by severe attacks of vertigo, nausea, and vomiting. Tends to begin between the ages of 33 and 55. Hearing loss affect low frequency tones before high tones. Comes in attacks, hearing appears to improve between attacks of vertigo. Presabyacusis (senile deafness) Due to an atrophy of the tiny hair cells and nerve fibers in the cochlea. Is progressive. Most commonly noticed around the age of 60. The onset can be premature if a person undergoes prolonged exposure to noise in adult life.
Nose Hayfever (Allergic rhinitis) No relation to hay or fever. Histamine release in response to allergen. Histamine causes swelling and itching. Nutrients: Vitamin C (buffered) P5P Magnesium Vitamin E Hesperadin Quercitin MC Zinc Green tea extract Selenium Bromelain Vitamin A EPO (GLA) Saccharide (Galactosamine) – Chestnut extract or Chestnut flour Lutein / Zeaxanthine – rich in skin and nasal passages
Homeopathic: Allium cepa Arsenicum album Euphrasia Ferrum phosphoricum Gelsemium Natrum muriaticum Nux vomica Sabadilla Wyethia
Herbs: Camomile Cayenne pepper – anti inflammatory Devil’s claw Echinacea Elder bark Garlic Goldenrod Goldenseal Eyebright Ground ivy Licorice root Nettle Ribwort
Muscle test for the needed dose and take it all at once. When symptoms come back take the dose again. In a couple of days, the symptoms should stay improved for a longer time. Decrease the dose. When symptoms are gone, continue with one capsule a day for the rest of the time when symptoms are usually present. Next year, start taking the remedy a week before symptoms usually start. In a couple years the symptoms will not come back at all. Sinusitis Chronic Inflammation Vasomotorrhinitis caused by humidity, cold air, alcohol, perfumes, and other environmental conditions, also may be complicated by sinus infections. Headache and sinus problems in the morning are from fungal spores. Nutrients: Ionic zinc Ionic silver Fatty acids C8-14 Echinacea Castor bean oil Horseradish + Garlic tincture Iodine – is secreted into saliva and mucus only if there is enough for the rest of the body. It is there because it is antimicrobial. Lacrimal ducts secrete iodine also. Deficiency causes glue ear and eye. Hands on Treatments Neurolymphatic reflexes for the sinuses (Posterior and Anterior) Cranial manipulation
Frontal Lift Maxillary Spread Zygoma Roll
Gout Gout Challenge Procedure 1. Patient weakens to Uric Acid 2. Test Nutrients: Zinc, Sodium Bicarbonate (a pinch every couple hours), Glucosamine, MSM, Omega 3, Artichoke (cynara), Celery Seed Extract, Chrysin, Garlic, Silymarin, Turmeric, Yucca Metabolic disorder of breaking down purines, which become uric acid. Uric acid can deposit in ankles, knees, big toe, thumbs, ear lobes Uric acid crystals do not show on xray. Symptoms Constant aching, stress, and tenderness in the worst way Inability to bend, loss of flexibility Hardness and swelling at the big toe or fingers, wrists, ankles, and knees Burning sensations and redness around the infected areas Constant pain Lingering joint pain Purine Rich Foods Red meats (cows or sheep) – Steak, Chops, Corned Beef, and larger pieces of meat usually roasted in the oven Game Meat extracts (Oxo, Bovril) Gravy Organ Meats – Brains, Kidneys, liver, Heart (offal) Sweetbreads Shellfish – Mussels, Oysters, Sea Eggs Seafood – Anchovies, Herrings, Mackerel, Sardines Peas and Beans Alcohol (beer and wine) Shiitake Mushrooms Caused by Hypoxia Too much Xanthine Oxidase activity Acid pH Inability to dissolve Uric Acid Pharmaceutical treatment Acute attack NSAID (not aspirin) Maintenance Sulfinpyrazone – Anturan (Promotes renal excretion) Allopurinol, Zyloric (Xanthine oxidase inhibitor) Gout Diet Grapes – Lowers acidity, Antioxidant Bananas – Bromelain, Potassium Cherries – Neutralizes uric acid, Anthocyanidins Pineapples – Rich in potassium (uric acid urates), Bromelain (anti inflammatory), Vitamin C (antioxidant to purines), Folate (tissue repair) Blueberries – Potassium, Anthrocyanidins (5 of the 6), Vitamin C Strawberries – Anthrocyanidin (pellegedenin), Vitamin C, Quercetin (as Quercetin Methyl chalcone (Quercetin MC from Thorne))
Gout Adenosine Guanosine P5P Inosine Hypoxanthine Guanine
Xanthine Oxidase Mo, Fe, Cu, FAD Vanadium, Folate, Tungsten, Quercetin
O2
Xanthine O2-
O2 Xanthine Oxidase FAD Mo, Fe, Cu O2- Vanadium, Folate, Tungsten, Chrysin, Quercetin Uric Acid Zinc pH 7+ (Sodium Bicarbonate (Baking Soda))
Acidic pH Sodium Urate
Neurobehavioral Disorders Areas of the Brain Forebrain Telencephalon (Cortex and Basal ganglia)
Diencephalon (Thalamus) Cerebellum Vermis and Cerebellar hemispheres Hind brain Mesencephalon (Mid brain)
Pons Medulla oblongata
Disorders Causes A lack of stimulation to one side of the brain A lack of communication between the two hemispheres. Communication is through the Corpus Callosum, mediated by Dopamine. Attention Deficit Disorder (ADD) Is considered a name for a spectrum of deficits of cognitive executive functions that may respond to similar treatments and are often combined with a wide variety of psychiatric disorders many of which may also be spectrum disorders. Probably low dopamine. Attention Deficit Hyperactive Disorder (ADHD) An impairment of higher order cognitive processing known as executive function whose function seems to primarily reside in the frontal lobes. Often associated with excess excitatory agonists (MSG, Aspartame). Pervasive Developmental Disorder (PDD) Patients have severe problems with executing appropriate social behavior. Strong overlap with ADHD. Obsessive Compulsive Disorder (OCD) There are varying degrees of overlap between OCD and ADHD. Usually associated with low serotonin. Aspberger’s syndrome Often called semantic-pragmatic disorder, right hemisphere learning disorder, nonverbal learning disability, and schizoid disorder. Autism Has many similar symptoms to ADHD. Many autistics are hyperactive and with executive dysfunction in attention, impulsivity, and distractibility. Probably have cerebellar pathology. Principle brain regions affected in learning disorders: 1. Cerebellum 2. Thalamus 3. Frontal lobes 4. Basal ganglia The CNS has more mitochondria than any other tissue in the body. ATP is needed to pump Na and K in and out of the cells. Therefore it is also the most oxygen hungry tissue of the body. Thalamus Major relay station for all sensory input except olfaction Transmit signals to the control centers for vision, hearing, touch, and somatosensation Information is sent to the parietal, temporal, and frontal lobes Information is sent to the hypothalamus for endocrine or autonomic responses All conscious input (pain, temperature, vibration, touch) crosses in the spinal cord, goes to the contralateral thalamus, and then the cortex
Neurobehavioral Disorders Cerebellum The cerebellum is smaller than the cortex but has more nerve fibers than the cortex does. All unconscious input (proprioception from joints and muscles) enters the spinal cord and ascends to the ipsilateral cerebellum then crosses through the thalamus to the contralateral cortex. 90+% of all neurological input is proprioception and it is all subconscious. The cerebellum is the most oxygen hungry area of the CNS. Low oxygen will cause balance problems. Cerebellar connections to the Frontal Lobe affect: Language Motor function Cortical arousal Alertness Attention Prefrontal Connections affect: Planning Verbal working Memory (along with frontal, parietal, and temporal lobes, the thalamus, the anterior and posterior cingulate gyrus, and the precuneus) Noradrenergic connections to the Locus Coerulus and Serotoninergic connections to the Raphe Nucleus regulate: Emotions Affective behavior Arousal Motivation Global behaviors (sleeping, waking) Basal Ganglia Regulates movements Dysfunction can cause characteristic motor, cognitive, and emotional symptoms that are often seen in children with cognitive and emotional affective disorders. Involved with the sequencing of movements. Dysfunction causes “Floppy Baby Syndrome” (dystonia). GV28 is the meridian point for the basal ganglia. Located in the diencephalon and is made up of 5 subcortical nuclei: 1. Globus pallidus 2. Caudate 3. Putamen 4. Sunstantia nigra 5. Subthalamic nucleus of Luys Cortex Occipital Lobe codes for visual features like color, luminance, spatial frequency, orientation, and movement. Most visual input is from the rods. Rods pick up changes in shades and see dark and peripheral vision, which is important in balance. Temporal Lobes are involved in auditory processing and memory recall. Neocortex is involved with thinking and making decisions. It is large in humans and absent in animals. Parietal Lobes perceive sensory input. Frontal Lobes accomplish goals, make decisions, express creativity, navigate through complex social situations and regulate goal directed behavior, a hierarchy of reflexive movements, cross temporal contingencies, approach and avoidance behavior, response inhibition, and perseveration.
The left frontal cortex advances and is inquisitive. Dysfunction (underfunctioning) leads to withdrawal and introversion. The right frontal cortex withdraws and is quiet. Dysfunction (underfunctioning) leads to uncontrollable advancing, aggression, ADD/ADHD.
By examining the motor function of the frontal lobe, the non motor function of the frontal lobe can likewise be assessed. Improvement in motor function should result in improvement in non-motor function of the frontal lobe. Activities that improve muscle tone, coordination, and timing and the control of skeletal muscle should also improve cognitive functions of the frontal lobe like verbal fluency, attention, and inhibition of eye movements.
Additional Neurological Information Hemisphere Characteristics Left Brain Right Brain Right body Linear Left body Spatial Logical Masculine Non-logical Feminine Mathematical Intellectual Tonal Intuitive Rational Argument Non-sensible Experience Reasonable Negative Unpredictable Positive Practical Time Non practical Timelessness Uses logic Detail oriented Uses feeling "Big picture" oriented Knowing Words and language Believes Symbols and images Acknowledges Math and science Appreciates Philosophy & religion Reality based Present and past Fantasy based Present and future Practical Facts rule Impetuous Imagination rules Safe Can comprehend Risk taking Can "get it" (i.e. meaning) Order/pattern perception Forms strategies Spatial perception Presents possibilities Knows object name Factual and detailed Knows object function Visual and conceptual Identifies words Emotionally negative Identifies patterns Emotionally positive Assigns meaning Classifies and judges Assigns value Plays and responds Interprets Processes sequentially Imagines Processes simultaneously Analyzes Orderly Synthesizes Spontaneous Critical Anxious Dreamy Suspicious Methodical Objectifies Random Animates Linear Meandering Uses symbols & ideas for sensations Values sensation for itself Follows rules and schedules Follows daydreams and impulses Color and Sound Relationships Red stimulates the Left brain and vibrates to Middle C which stimulates the Right brain Orange stimulates the Left brain and vibrates to D which stimulates the Right brain Yellow stimulates the Left brain and vibrates to E which stimulates the Right brain Green stimulates the Left brain and vibrates to F#, which stimulates the Right brain Blue stimulates the Right brain and vibrates to G, which stimulates the Left brain Indigo stimulates the Right brain and vibrates to A, which stimulates the Left brain Violet stimulates the Right brain and vibrates to B, which stimulates the Left brain Right hemisphere stimulated by low frequency sound. Left hemisphere stimulated by high frequency sound. Frequency = Speed of light / Wavelength Frequency is measured in Herz (Hz). Wavelength is measured in a distance (meters, nanometers, etc). “Meridian” Point for Basal Ganglia Basal ganglia problems will cause lack of muscle tone called dystonia. In a baby, they will be described as a “floppy baby”. Rubbing these points will stimulate the basal ganglia and can improve the muscle tone. The points are on the foot between the medial and superior aspects of the proximal phalanx on the big toe. It is not a true meridian point, but is thought to work through the spleen meridian. The point will TL. Treatment is to rub vigorously every day.
The Seven Ages of Man All the world's a stage, And all the men and women merely players; They have their exits and their entrances; And one man in his time plays many parts, His acts being seven ages. At first the infant, Mewling and puking in the nurse's arms; Then the whining school-boy, with his satchel And shining morning face, creeping like snail Unwillingly to school. And then the lover, Sighing like furnace, with a woeful ballad Made to his mistress' eyebrow. Then a soldier, Full of strange oaths, and bearded like the pard, Jealous in honour, sudden and quick in quarrel, Seeking the bubble reputation Even in the cannon's mouth. And then the justice, In fair round belly with good capon lin'd, With eyes severe and beard of formal cut, Full of wise saws and modern instances; And so he plays his part. The sixth age shifts Into the lean and slipper'd pantaloon, With spectacles on nose and pouch on side; His youthful hose, well sav'd, a world too wide For his shrunk shank; and his big manly voice, Turning again toward childish treble, pipes And whistles in his sound. Last scene of all, That ends this strange eventful history, Is second childishness and mere oblivion; Sans teeth, sans eyes, sans taste, sans everything."
– Shakespeare’s As You Like It 1. The Infant: In this stage he is dependent on others and needs to be constantly attended to. Post Partum Depression Lactation Colic 2. The School boy (Childhood): It is in this stage that he begins to go to school. He is reluctant to leave the protected environment of his home as he is still not confident enough to exercise his own discretion. Nutrients for children Nutrients for teens Nutrients for menarche ADHD Exam performance Children seminar 3. The Lover (Adolescence): In this stage, he is always remorseful due to some reason or other, especially the loss of love. He tries to express feelings through song or some other cultural activity. Infertility 4. The Soldier (Young Adult): He thinks less of himself and begins to think more of others. He is very easily aroused and is hot headed. He is always working towards making a reputation for himself and gaining recognition, however short lived it may be, even at the cost of his own life. Pregnancy Labor 5. The Justice (Adult): In this stage, he has acquired wisdom through the many experiences he has had in life. He has reached a stage where he has gained prosperity and social status. He becomes very attentive of his looks and begins to enjoy the finer things of life. Optimal Eating Reactive Oxygen Species Bone Density 6. The Pantaloon (Old age): He begins to lose his charm, both physical and mental. He begins to become the brunt of others' jokes. He loses his firmness and assertiveness and shrinks in stature and personality. Emotional Outlook 7. Second Childhood (Dementia and Death): He loses his status and he becomes a non-entity. He becomes dependent on others like a child and is in need of constant support before finally dying.
The Infant Babies are 100% made from mom, sometimes at the expense of the mother’s nutrient stores. After birth, priority goes to the mom. Breastfeeding while mom is deficient in nutrients will make baby deficient. Post Partum Depression Occurs usually 40-48 hours after birth or when the milk comes in. Magnesium deficiency following massive loss due to smooth muscle contraction through the labor. 15-Hydroxy estrogens are present in pregnancy and are metabolized by Magnesium. Zinc deficiency as there is high zinc loss on expulsion of the placenta. Omega 3 fatty acids can be taken from the mom and given to the baby during pregnancy, which can cause mother’s brain to shrink. Lactation Suckling initiates afferent impulses that travel by sensory neurones from the areola to the hypothalamus. This stimulates magno-cellular neurones that stimulate the posterior pituitary to release oxytocin, which causes contraction of the myo-epithelial cells and release of milk. Increasing Milk Production 1. Increase infant suckling 2. Increase water intake 3. Take herbal galatagogue, such as Anise seed, Blessed thistle, Chaste berry, Fennel Seed, Fenugreek, Hops, Milk Thistle Seed, Nettle Leaf, Raspberry leaf tea 4. Avoid large amounts of sage and parsley which may decrease milk flow Colic – spasm of the smooth muscle of the intestines 1. Mother’s milk – use surrogate to test mother’s milk which can have contaminants from mother’s diet or mobilization of mother’s fat. 2. Allergy to mother’s diet. Brassicas or other pungent foods, wheat, and milk are often involved. 3. High calcium to magnesium ratio from hard or mineral water. Ionic Magnesium works well for babies. 4. Potassium deficiency slows peristalsis 5. Protein deficiency slows peristalsis 6. B vitamin (B1, B5) deficiency slows peristalsis. B5 is needed to make Acetylcholine. 7. Probiotics should be inoculated during birth. C section birth will prevent inoculation and antibiotics during pregnancy, chlorinated water, and food preservatives will kill the bacteria. B. infantalis is the only probiotic for an infant. 8. Infection – bacteria, virus, fungus, parasite 9. Cranial faults will affect digestion. Common after the trauma of birth and from bumps to the head. Correct using All in One Technique.
Childhood The major requirements a for toddlers from one year to three (roughly) Calories 1300 Protein 16 grams Vitamin A 400ug Vitamin C 40mg Thiamin 0.7mg Riboflavin 0.8mg Niacin 9mg Pyridoxine 1mg Folate 50ug Calcium 800mg Important nutrients in infants and children 1. Calcium, Phosphorous, Vitamin D – supplementing will reduce risk of osteoporosis later on 2. Iron – breastfed babies with iron deficient mothers 3. Vitamin K – in hemorrhagic disease 4. Essential fats – for brain and eye development 5. Zinc Important nutrients in teens (ages 12-17) 1. Increased need for protein, calories, and nutrients 2. Calcium 1200-1500mg/day for bone mass. Calcium citrate is about 10% calcium. A 500mg capsule will be 100mg calcium and 400mg citrate. Other forms have less calcium. Phosphorous in soft drinks will flush out calcium. 3. Folic acid for growth 4. Iron – rise in hemoglobin levels 5. Omega 3 fatty acids Nutritional Requirements at Puberty in Females 1. Bone calcium reaches a maximum in females shortly before menarche. At that time bone deposition rate is 5x that of adult. There is a decline in bone calcium deposition rate after menarche. 2. Increased nutrients are required by the pituitary, ovaries, and adrenal glands (Manganese, Niacin, Iron, E). 3. Omega 3 improves dysmenhorea in adolescents when taken for more than 3 months by decreasing PG2. 4. Magnesium improves dysmenorrhea by stopping uterine cramps. Attention Deficit Hyperactivity Disorder in children (ADHD) Symptoms: attention deficit, impulsivity, hyperactivity, mood swings, temper tantrums, disorganization, inability to cope with stress or stay focused Causes: genetic factors, food additives, foods, environmental chemicals, molds and fungi, toxins (heavy metals, organo-chlorine pollutants), thyroid dysfunction Nutritional Deficiencies: P5P, Magnesium, Zinc, Omega 3 and 6 fatty acids, flavonoids, phosphatidylserine Treatment: supplement, dietary changes, detoxification, correction of intestinal dysbiosis, ginseng, ginkgo biloba, cranial and emotional work Exam Support Formula High Omega 3 intake for at least 3 months prior to exams 1 week before exam – start aerobic exercise 15 minutes 1-2 x per day 3 days before exams and during exam period care with diet:
No refined sugars Protein (boiled egg), fruit, and whole-wheat toast for breakfast Fruit juice, nuts, and raisins mid morning Protein, whole-wheat bread, and 1 pint water for lunch Nuts and raisins mid afternoon Nutritious evening meal
Before exam morning or afternoon – cycle, walk, or run to school Take 3x Omega 3, 2x Ginkgo biloba, 2x Nutrient Phase 1&2, 10 squirts XS Ionic Zinc, Phosphatidylcholine or Phospholipid mix
Children Choline Should be taken by the mother during first 16 weeks of pregnancy and by the child for 3 months after birth Take Two 500mg capsules of Choline bitartrate to provide 400mg Choline (Choline Bitartrate is 40% Choline) Improves learning and memory Cranial Faults Indications History of difficult birth Non symmetrical shaped head Excessively quiet or fractious (moans and groans) Altered physiological habits (eat too little, too much) Sleep changes Causes Trauma (birth) Allergy – something the baby is eating, something the mother is eating (if breastfeeding) See Procedure under GV 20 Pyloric Stenosis Mechanism Pyloric sphincter is a valve at the distal end of stomach It is controlled by the Vagus Nerve, which exits through the Jugular Foramen The Vagus Nerve can be impinged by a lateral atlas or by cranial restrictions Compression affects the end organs and the Pyloric Sphincter closes Symptoms Projectile vomiting Glue Eye and Ear (secretory otitis media, otitis media with effusion, or serous otitis media) Mechanism Fluid builds up in the ear, becomes thick, and stops the ossicles from moving, leading to hearing loss Symptoms Loss of hearing Common Causes Cranial Faults Ionic silver for Gram + is safe for newborn children Atlas Ionic Mo or Immune WHY for Gram - Allergy / Intolerance – cow milk Ionic zinc for fungus Infection Bacteria, Virus, Fungus Deficiency Zinc, Iodine, Vit A, Vit C Mucus Composition Water Mucin Saccharide chains Amino acids – serine, threonine, proline, asparagine, aspartate, glutamine, glutamate Others Phospholipids Electrolytes Bonds N-Acetylgalactosamine, N-Acetylglucosamine, Galactose, N-Acetylneuraminic acid, Mannose, Fucose Functions of Mucin Give gel like properties to mucus Lubricate and form a protective barrier on epithelium Mask surface antigens from immune surveillance Modulate oral microflora
Appendix
1. Enzymes Scales
2. Verbal Challenges
3. Gifts, Skills, and Talents
4. Quantum Entanglement Electroencephalography Vestibulo-Ocular Reflex The Three Ages of Man
5. Procedure Checklist
B+E point Chart
6. Neurological Tests Checklist
7. Immune System Chart
8. Quick Reference for Conditions
9. USA Vaccines
10. Test Kits
11. Periodic Table
Gifts, Skills, and Talents Patient Name Date
Gift Definition Potential Current Expression
Wisdom The expression of the Higher Self
Hospitality Service in action
Teaching The ability to inspire others to awareness
Giving Contributing unconditionally
Faith To act with inner knowledge of truth
Healing The ability to restore sick and diseased
people and animals to wholeness
Creative Communication Artistic expression of love
Prediction / Prophecy The ability to access eternity
Knowledge Communication to the Higher Self
Entrepreneurship Demonstrate authority and vision with the ability to start and oversee the development of new ventures
Interpretation The ability to gather together information, process and integrate it into an understandable form
Leadership The ability to guide
Discernment The ability to perceive truth
Encouragement The ability to enable others to express and realize their gifts
Compassion Express love to those facing hardship
Evangelism Clear communication with conviction
Miracles The ability to perform supernatural events
Administration Create order out of chaos
Shepherding The gift of looking after the needs of others
Language The gift of communication
Craftsmanship The gift of expression of creativity
Intercession Intervention to create harmony between people
Service Seeing the needs of others
“Taking into account all your Gifts, Skills, and Talents, your current career (or your current direction in your life) calibrates at ______________ out of 1000 for total suitability in every way.”
Gifts, Skills, and Talents Gifts, Skills, and Talents are the direct expression of the Superconscious. They are everlasting qualities that make a person who they are. Having more or less is not bad, but indicates the level of responsibility a person has in their life. A person’s purpose in life is full expression of their given gifts. A person may have a gift but not be expressing it due to unconscious emotions. Anxiety and Fear is the most common unconscious emotion that interferes with full expression. Indications: Looking for a new career, Looking for a first career, Questioning if your direction in life is right “On a Scale of 1-1000, the Gift, Skill, or Talent of __ right now calibrates at (200, 500, 800, 1000) for you.” 1. Wisdom The expression of the Higher Self
“The relinquishment of judgement” (Wise people listen and guide, they don’t judge and don’t tell you what to do) 2. Hospitality Service in action 3. Teaching The ability to inspire others to awareness 4. Giving Contributing unconditionally 5. Faith To act with inner knowledge of truth
With a guiding light all obstacles can be overcome 6. Healing The ability to restore sick and diseased people and animals to wholeness 7. Creative Communication Artistic expression of love The love of artistic expression 8. Prediction (Prophecy) The ability to access eternity 9. Knowledge Communication to the Higher Self 10. Entrepreneurship Demonstrate authority and vision with the ability to start and oversee the
development of new ventures 11. Interpretation The ability to gather together information, process and integrate it into an
understandable form (To make complicated things easy) 12. Leadership The ability to guide
“A leader is one who knows the way, goes the way, and shows the way" 13. Discernment The ability to perceive truth 14. Encouragement The ability to enable others to express and realize their gifts 15. Compassion Express love to those facing hardship (Unconditional love) 16. Evangelism Clear communication with conviction 17. Miracles The ability to perform supernatural events 18. Administration Create order out of chaos 19. Shepherding The gift of looking after the needs of others 20. Language The gift of communication (Not speaking many languages) 21. Craftsmanship The gift of expression of creativity 22. Intercession Intervention to create harmony between people 23. Service Seeing the needs of others For each Gift, Skill, or Talent that calibrates to 1000, test its current expression in the patient’s life. “The gift of ______ is being expressed in your life at (200, 500, 800, 1000).” “Taking into account all your Gifts, Skills, and Talents, your current career (or your current direction in your life) calibrates at ______ out of 1000 for total suitability in every way.”
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Oil,
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0M
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0M
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10M
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M
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0M
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Car
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10M
Nat
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M
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10M
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10M
K
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10M
Nux
Vom
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10M
Si
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10M
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Ioda
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10M
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0M
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G
else
miu
m 1
0M
Lach
esis
10M
Phyt
olac
ca 1
0M
Thuj
a O
ccid
10M
C
alci
um C
arb
10M
G
raph
ites 1
0M
Lyco
podi
um 1
0MPl
umbu
m M
etal
licum
10M
Zi
ncum
Met
allic
um 1
0M
Cyt
okin
eTu
mor
Nec
rosi
s Fac
tor A
lpha
(TN
F-a)
6x
IL- 4
6x
IL- 1
2 6x
Ig
M 6
x Fi
brob
last
Gro
wth
Fac
tor (
FGF)
6x
Tum
or N
ecro
sis F
acto
r B
eta
(TN
F-b)
6x
IL- 5
6x
IL- 1
3 6x
Ig
E 6
x Pl
atel
et D
eriv
ed g
row
th F
acto
r (PD
GF)
6x
Inte
rfer
on A
lpha
(IFN
-a) 6
x IL
- 6 6
x c
AM
P 6x
Ig D
6x
Tran
sfor
min
g G
row
th F
acto
r a (T
GFa
) 6x
Inte
rfer
on B
eta
(IFN
-b) 6
x IL
- 7 6
x c
GM
P 6x
ICA
M 6
x Tr
ansf
orm
ing
Gro
wth
Fac
tor b
(TG
F b)
6x
Inte
rfer
on G
amm
a (I
FN-g
) 6x
IL- 8
6x
GM
-CSF
6x
SAM
6x
C. R
eact
ive
prot
ein
6x
Inte
rleuk
in 1
(IL-
1) 6
x IL
- 9 6
x G
-CSF
6x
P. A
. Glu
tam
ine
Epid
erm
al G
row
th F
acto
r (EG
F) 6
X
Inte
rleuk
in 2
(IL-
2) 6
x IL
- 10
6x
Ig G
6x
Insu
lin L
ike
Gro
wth
Fac
tor (
IGF
1) 6
x IL
- 3 6
x IL
- 11
6x
Ig A
6x
Orth
opho
spho
tyro
sine
(OPT
) 6x
Det
ox B
ox 1
Det
ox 1
Cra
nial
Kle
bsie
lla 3
0xEp
stei
n B
arr V
irus 3
0xV
aric
ella
30x
D
etox
2B
ody
Clo
ckLi
ster
ia 3
0x
Echo
30x
V
ario
lium
30x
D
etox
3M
ucus
Men
ingo
cocc
30x
H
epat
itis A
30x
A
moe
ba 3
0X
Det
ox 4
Men
ingi
tis C
Vac
cine
30x
Pneu
moc
occ
30x
Hep
atiti
s B 3
0x
Asc
arid
es 3
0X
Det
ox 5
MM
R V
acci
ne 3
0xPs
eudo
mon
us 3
0x
Hep
atiti
s C 3
0x
Bilh
arzi
a 30
X
Viru
sTr
iple
Vac
cine
30x
Pr
oteu
s 30x
H
erpe
s Gen
italia
30x
Bla
sto
Hom
in 3
0X
Post
Viru
sA
nti C
olib
ac 3
0x
Pyog
eniu
m 3
0x
Her
pes S
impl
ex 3
0xB
ruce
llosi
s 30X
B
acte
riaB
acill
inum
30x
Sa
lmon
ella
30x
H
erpe
s Zos
ter 3
0xC
hlam
ydia
30X
Pa
rasi
teC
ampy
loba
ct 3
0x
Stap
hloc
occ
30x
HIV
30x
C
rypt
ospo
rid 3
0X
Fung
usC
. diff
icile
30x
St
aph
Hea
m 3
0x
Hum
an P
apill
oma
30x
Dys
inte
ria 3
0X
Che
mic
alC
hole
ra 3
0x
Stap
hylo
tox
30x
Hum
an W
art 3
0x
E. H
artm
anni
30X
H
ydro
carb
onC
lost
ridiu
m 3
0xSt
rept
ococ
c 30
x In
fluen
za 3
0x
Endo
limax
30X
To
xic
Met
alC
olib
acill
in 3
0x
Syph
ilis 3
0x
Legi
onel
la 3
0x
Enta
moe
ba 3
0X
Alle
rgy
Cor
yneb
acte
r 30x
Te
tanu
s 30x
M
onon
ucle
osis
30x
Ente
r. V
erm
ix 3
0X
Rad
iatio
nD
ipth
eria
30x
Tu
berc
ulin
um 3
0x
Mor
billi
num
30x
Gia
rdia
sis 3
0X
Mal
igna
ncy
E. C
oli 3
0x
Mia
sms
Parp
tidiin
um30
x H
ookw
orm
30X
Ly
mph
Ente
ritis
30x
A
deno
Viru
s 30x
Pertu
ssin
30x
Le
ptos
piro
sis 3
0X
Anx
iety
Ente
roco
cc 3
0x
Cox
sack
ie 3
0x
Polio
mye
litis
30x
Ly
mes
30X
D
epre
ssio
nG
onor
rhea
30x
C
ytom
egal
o V
irus 3
0xR
otav
irus 3
0x
Mal
aria
30X
. St
ruct
ure
Hel
icob
acte
r Pyl
ori 3
0xD
engu
e 30
x R
ubel
la 3
0x
Det
ox B
ox 2
Psitt
acos
is 3
0X
Rho
doto
rula
30X
C
hlor
ofor
m 3
0X
Ars
enic
30X
200
X 1
M
Cad
miu
m 3
0X 2
00X
1M
St
rong
yloi
d 30
X
Spor
otric
hum
30X
D
ioxi
n 30
X
Aur
um 3
0X 2
00X
1M
Ura
nium
30X
200
X 1
M
Toxo
plas
mos
is 3
0X
Tric
hode
rma
30X
D
DT
30X
B
eryl
lium
30X
200
X 1
M
Rad
ium
Bro
mid
e 10
00x
Tric
h.(T
richu
r) 3
0X
Tea
6X
Ethy
lene
Gly
30X
C
easi
um 3
0X 2
00X
1M
Phos
phor
ous 6
0XTr
icho
mon
as 3
0X
Cof
fee
6X
Etha
nol 3
0X
Cob
alt 3
0X 2
00X
1M
Si
licea
60X
C
esto
des
Cow
Milk
6X
Fo
rmal
dehy
de 3
0xC
upriu
m30
X 2
00X
1M
C
hrom
ic P
ulp
Nem
atod
es
Whe
at 6
X
Her
bici
des 3
0xG
allu
ium
30X
200
X 1
M
Fluo
rine
Tox
Prot
ozoa
C
itric
Aci
d 6X
M
etha
nol 3
0X
Irid
ium
30X
200
X 1
M
Gan
gren
. Pul
pSp
oroz
oa
Che
ese
6X
Nap
thal
ene
30X
Ir
on 3
0X 2
00X
1M
G
ingi
vitis
Tr
emat
odes
H
am 6
X
Nitr
ic A
cid
30X
Li
thiu
m 3
0X 2
00X
1M
Impa
ctio
n A
ltern
aria
30X
Eg
g 6X
Pa
raqu
at 3
0X
Mer
c M
et/S
ol 3
0X 2
00X
1M
M
ax S
inus
A
sper
gillu
s 30x
C
hoco
late
6X
Pe
ntac
hlor
ph 3
0xN
icco
llum
30X
200
X 1
M
Occ
lusi
on
Can
dida
Alb
30X
To
mat
o 6X
Pe
stic
ides
30X
Pa
lladi
um 3
0X 2
00X
1M
R
oot C
anal
C
andi
da T
rop
30x
Cor
n 6X
Pe
trole
um 3
0X
Plat
inum
30X
200
X 1
M
Perid
ontit
isC
epha
losp
or 3
0X
Ace
tone
30X
Ph
enol
30X
Pl
umbu
m 3
0X 2
00X
1M
O
stiti
s C
lado
spor
um 3
0X
Asb
esto
sis 3
0X.
Prus
sic
Aci
d 30
X
Rad
ium
30X
200
X 1
M
Polo
nium
30X
200
X 1
M
Epic
occu
m 3
0X
Ben
zene
30X
To
luen
e 30
X
Rad
on 3
0X 2
00X
1M
Rad
icul
. Cys
t Fu
sariu
m 3
0X
Ben
zopy
rene
30X
TR
IC 3
0X
Stan
num
30X
200
X 1
M
Toxi
c A
mal
gam
Glio
clad
ium
30X
B
SE 3
0X
Alu
min
ium
30X
200
X 1
M
Stro
ntiu
m 3
0X 2
00X
1M
Pa
rkin
sons
30X
M
icro
spor
um 3
0X
Car
bolic
Aci
d 30
xA
ntim
ony
30X
200
X 1
M
Thal
ium
30X
200
X 1
M
Hod
gkin
s 30X
Pe
nici
llum
30X
C
hlor
ine
30X
A
rgen
t 30X
200
X 1
M
Thor
ium
30X
200
X 1
M
Mul
tiple
Scl
eros
is 3
0X
Det
ox B
ox 3
M
iddl
e Ea
r 12X
Inne
r Ear
12X
C
onst
itutio
nC
hakr
a 1
+ 7
Cha
kra
1 +
7 +
2 C
hakr
a 1
+ 7
+ 3
Cha
kra
1 +
7 +
4 C
hakr
a 1
+ 7
+ 5
Cha
kra
1 +
7 +
6
Dia
gnos
tic P
ain
Box
1A
cety
lcho
line
6xA
dren
al M
edul
la 6
xPh
osph
oeno
lpyr
uvat
e 6x
TMPD
6c
Alle
rgy
6xA
spar
tate
6x
Live
r 6x
Pyru
vate
6x
Gly
coge
nH
ista
min
e 6x
Hom
ocys
tein
e 6x
Ova
ries 6
xA
cety
l CoA
6x
UD
P G
luco
se 6
xK
inin
6x
Cys
tein
e 6x
Panc
reas
6x
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ate
6xG
luco
se 1
Pho
spha
te 6
xSe
roto
nin
6xC
yste
ine
Sulp
hina
te 6
xPa
rath
yroi
d 6x
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itrat
e 6x
Gly
cera
ldeh
yde
3 Ph
osph
ate
6xPr
osta
glan
dins
6x
Taur
ine
6xPi
neal
6x
Alp
ha K
etog
luta
rate
6x
NA
DPH
6x
Leuk
otrie
nes 6
xL
Dop
a 6x
Pitu
itary
6x
Succ
inyl
CoA
6c
Tran
sket
olas
e 6c
C R
eact
ive
Prot
ein
6xD
opam
ine
6xPr
osta
te 6
xSu
ccin
ate
6xR
ibul
ose
5 Ph
osph
ate
6xN
F K
appa
B 6
xN
orad
rena
line
6xSp
leen
6x
Fum
arat
e 6x
Rib
ose
5 Ph
osph
ate
6xB
acte
ria 6
xG
AB
A 6
xTe
stes
6x
Mal
ate
6xPa
lmiti
c A
cid
Viru
s 6x
Glu
tam
ate
6xTh
ymus
6x
Oxa
loac
etat
e 6x
Stea
ric A
cid
Post
Viru
s 6x
Gly
cine
6x
Thyr
oid
6xN
AD
HA
rach
idic
Aci
dFu
ngus
6x
His
tam
ine
6xU
teru
s 6x
FAD
H2
6xB
ehen
ic A
cid
Prot
ozoa
6x
5HTP
6x
ATP
6x
Din
itrop
heno
l 6x
Trip
alm
itin
6xC
esto
de 6
xSe
roto
nin
6xA
DP
6xA
zide
6x
Palm
itoyl
e C
oATr
emat
ode
6xTy
ram
ine
6xFr
ucto
se 1
Pho
spha
te 6
xD
CC
D 6
xPa
lmito
yle
Car
nitin
e 6x
Nem
atod
e 6x
Asp
arta
me
6xG
luco
seR
oten
one
6xIg
ESp
oroz
oa 6
xM
SG 6
xG
luco
se 6
Pho
spha
te 6
xO
ligom
ycin
6x
IgG
Che
mic
als 6
xC
yber
met
hrin
6x
Fruc
tose
6 P
hosp
hate
6x
Car
bony
lcya
nide
6x
IgM
Toxi
c M
etal
s 6x
Adr
enal
Cor
tex
6xD
ihyd
roxy
acet
one
Phos
phat
e 6x
Mal
onic
Aci
d 6x
IgA
Rad
iatio
n 6x
Dia
gnos
tic P
ain
Box
2Su
pero
xide
NA
DH
Per
oxid
ase
6xC
ytoc
hrom
e P4
50 6
xH
epar
in 6
xTo
luen
eN
AD
PH 6
xPe
roxi
dase
6x
Glu
tath
ione
S T
rans
fera
seH
epar
an S
ulfa
te 6
xPh
enol
H2O
2 (P
erox
ide)
Mye
lope
roxi
dase
6x
Sulfi
te O
xida
seLa
min
in 6
xA
mm
onia
Sodi
um F
luor
ide
4 H
ydro
xyno
nena
lPA
PsK
erat
an S
ulfa
te 6
xU
rea
Mag
nesi
um Io
dide
Xan
thin
e O
xido
redu
ctas
e 6x
Glu
curo
nic
Aci
dPr
osta
te S
peci
fic A
ntig
en (P
SA) 6
xN
Ace
tyl G
luta
mat
eM
agne
isum
Chl
orid
eH
2OSA
MN
erve
Gro
wth
Fac
tor (
NG
F) B
eta
6xC
arba
moy
l Pho
spha
teM
agne
sium
Bro
mid
eH
yalu
roni
c A
cid
6xA
cety
l CoA
cGM
P 6x
Arg
inos
ucci
nate
Pota
ssiu
m Io
dide
Cho
ndro
itin
6 Su
lfate
Gly
cine
cAM
P 6x
Indo
lePo
tass
ium
Chl
orid
eC
hond
roiti
n 4
Sulfa
teTa
urin
ePl
atel
et D
eriv
ed g
row
th F
acto
r (PD
GF)
6x
Fibr
inPo
tass
ium
Bro
mid
eG
luco
seC
yste
ine
Insu
lin L
ike
Gro
wth
Fac
tor (
IGF)
6x
Met
hion
ine
Sulp
hoxi
deTh
iocy
anat
eG
luco
se 6
Pho
spha
teTh
reon
ine
Orth
opho
spho
tyro
sine
(OPT
) 6x
L La
ctic
Aci
dH
ypoc
hlor
iteFr
ucto
se 6
Pho
spha
teH
omoc
yste
ine
6xEp
ider
mal
Gro
wth
Fac
tor (
EGF)
6X
D
Lac
tic A
cid
Nitr
ic O
xide
Glu
cosa
min
e 6
Phos
phat
eH
omoc
yste
ine
Thio
lact
one
6xTr
ansf
orm
ing
Gro
wth
Fac
tor a
(TG
Fa) 6
xD
L La
ctic
Aci
dIn
duci
ble
NO
Syn
thas
e (I
NO
S) 6
xN
Ace
tyl D
Glu
cosa
min
e 1
Phos
phat
eC
olla
gen
1 6x
Tran
sfor
min
g G
row
th F
acto
r b (T
GF
b) 6
x D
Suc
rose
SOD
Cu/
ZnU
DP
N A
cety
l D G
luco
sam
ine
Col
lage
n 2
6xFi
brob
last
Gro
wth
Fac
tor (
FGF)
6x
Cas
ein
SOD
Mn
6xU
DP
N A
cety
l D G
alac
tosa
min
eC
olla
gen
3 6x
Car
cino
embr
yoni
c A
ntig
en (C
EA) 6
xD
Lac
tose
SOD
Fe
6xIn
sulin
6x
Col
lage
n 4
6xEt
hano
lG
lute
nC
atal
ase
6xPr
oins
ulin
6x
Col
lage
n 5
6xA
ceta
ldeh
yde
Oxi
dize
d C
hole
ster
olM
yelo
pero
xida
se 6
xG
luca
gon
6xEl
astin
6x
Ace
tic A
cid
Cho
lest
erol
Glu
tath
ione
Per
oxid
ase
6xPr
oglu
cago
n 6x
Fibr
onec
tin 6
xD
Ara
bini
tol
Uric
Aci
d
Functional Biochemistry Clinical Reference Guide About the Authors
Chris Astill-Smith is a registered Osteopath graduating from the British School of Osteopathy in 1970. He lectured in Nutrition and Dietetics at the British School of Osteopathy from 1973-1980 and in Arthrology and Myology from 1981-1989. He obtained his Diplomate from the International College of Applied Kinesiology in 1988 and lectures internationally on Functional Biochemistry most weekends. He was awarded Assistant Professor status at the Institute for Manual Medicine in Russia in 1992. Chris calls upon 41 years of experience of clinical management and shares his extensive knowledge in the subject as well as a multitude of clinical pearls. In 2011, Chris co-founded Epigenetics International, Ltd.
Epigenetics is mediated by environmental signals through perceptions which in turn can change the read out of our genes. How you see the world selects which genes are going to be activated and modifies the read out to make proteins that best fit the environmental circumstances of the time. Perception runs our genes, but not all perceptions are true. Misperceptions can miss run our genes. Misperceptions are interpretations of the world that are inaccurate. Inaccurate perceptions will inaccurately run our biology which will lead to dysfunctions and disease which is why thought becomes a prominent contributor to the state of health we express. Perception is the primary mechanism that controls our biology.
Casey Reardon is a licensed Chiropractor practicing in Pennsylvania, USA. After graduating from New York Chiropractic College in 2007 with 300 hours of Applied Kinesiology training, he continued his AK education with hundreds of hours of classes, including many of Chris Astill-Smith’s seminars. This book was born from those seminars to help all of Chris’s students to quickly and easily bring his work into their clinics.
www.epigenetics-international.com