Full Spectrum Cell AnalysisTM - LIANKE) BIO...CD125 CD126 FcεR1 IL-33R (ST-2) Pan Markers CD11b CD13 CD15 CD32 CD33 Surface Basophil Marker CD9 CD11a CD13 CD16 CD25 CD33 CD38 CD43

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Table of Contents

Format Abbreviations References UniProt: The Universal Protein Resource http://uniprot.org

Human Cell Differentiation Molecules http://www.hcdm.org

Leukocyte and Stromal Cell Molecules by Zola, H., et al., 2007. John Willey & Sons, Inc.

Alexa Fluor® is a registered trademark of and licensed under patents assigned to Molecular Probes, Inc. for research use only.

eFluor® is a registered trademark of eBioscience, Inc.

All designated trademarks used are the property of their respective owners.

Abbreviations Act Activated ASV Alternative Splice Variants ADCC Antibody-Dependent Cellular Cytotoxicity AML Acute Myeloid Leukemia APC Antigen Presenting Cells BM Bone Marrow CCRSF Complement Component Receptor Superfamily CD Cluster of Differentiation CHO Carbohydrate Moiety CNS Central Nervous System CRSF Cytokine Receptor Superfamily CTL Cytotoxic T Lymphocytes DC Dendritic Cells ECM Extracellular Matrix Endoth Endothelial Cells Epith Epithelial Cells ESC Embryonic Stem Cells FDC Follicular Dendritic Cells GPI Glycophosphatidylinositol Gran Granulocytes HEV High Endothelial Venule HUVEC Human Umbilical Vein Endothelial Cells HSC Hematopoietic Stem Cells IgSF Immunoglobulin Superfamily Intra/Txn Intracellular/Transcription Factors

kD KiloDalton KO Knock-out LAK Lymphokine Activated Killer Leuk Leukocytes LPS Lipopolysaccharide LRRF Leucine Rich Repeat Family Lymph Lymphocytes Mac Macrophages MHC Major Histocompatibility Complex Mono Monocytes NK Natural Killer Cells PBMC Peripheral Blood Mononuclear Cell pDC Plasmacytoid Dendritic Cell PNS Peripheral Nervous System RBC Red Blood Cells RTK Receptor Tyrosine Kinase Th T Helper Cells TF Transcription Factor TM Transmembrane TM12SF 12-Transmembrane Spanning Protein Superfamily TM4SF 4-Transmembrane Spanning Protein Superfamily TM7SF 7-Transmembrane Spanning Protein Superfamily TNFRSF TNF Receptor Superfamily TNFSF TNF Superfamily w/ Associates With

FG Purified Functional Grade Purified (sterile & azide-free)

FG Biotin Functional Grade Biotin (sterile & azide-free)

FITC Fluorescein Isothiocyanate

PE Phycoerythrin

PE-eFluor® 610 Phycoerythrin-eFluor® 610 Tandem

PE-Cyanine5 Phycoerythrin-Cyanine5 Tandem

PerCP-Cyanine5.5 Peridinin Chlorophyll Protein-Cyanine5.5 Tandem

PerCP-eFluor® 710 Peridinin Chlorophyll Protein-eFluor® 710 Tandem

PE-Cyanine7 Phycoerythrin-Cyanine7 Tandem

APC Allophycocyanin

APC-eFluor® 780 Allophycocyanin-eFluor® 780

B Cell Markers . . . . . . . . . . . . . . 4

CD4 T Cell Markers . . . . . . . . . . . . 6

CD8 T Cell Markers . . . . . . . . . . . . 8

Dendritic Cell Markers. . . . . . . . . . 10

Endothelial Cell Markers . . . . . . . . 12

Granulocyte Markers . . . . . . . . . . 14

Macrophage/Monocyte Markers . . . . . 16

Megakaryocyte/Platelet Markers . . . . 18

NK/ILC Markers . . . . . . . . . . . . . 20

NKT/γδ T Cell Markers . . . . . . . . . 22Stem Cell Markers. . . . . . . . . . . . 24

Other Cell Type Markers. . . . . . . . . 26

Human CD Antigens . . . . . . . . . . 28

Human Non-CD Antigens . . . . . . . . 48

Mouse CD Antigens . . . . . . . . . . 52

Mouse Non-CD Antigens . . . . . . . . 68

B Cell MarkersHuman

Intra/TxnAIDBach2Bcl-6IRF8Pax5

Memory

Follicular

SurfaceCD45R (B220)CD81

SurfaceCD9CD19low/neg

CD20low/neg

CD27CD31CD38CD81

CD133 CD138 CD184 (CXCR4)CD252 (OX40 Ligand)CD269 (BCMA)

SurfaceCD27IgG

SurfaceCD1dCD9CD21/35high

CD45R (B220)CD81CD103CD180 (RP105)CD268 (BAFF Receptor)CD307d (FcRL4)IgM

SurfaceCD20CD21CD22CD23hCD24CD40hCD45R (B220)CD69hCD80h

CD81CD86hCD137 (4-1BB)hCD275 (B7-H2)CD279 (PD-1)CD360 (IL-21 Receptor)HLA-DRIgDhigh

IgMlow/int

Intra/TxnBlimp1IRF4XBP-1

SecretedIgAIgEIgG

SecretedIgAIgEIgG Plasma

Cell

Germinal Center

MarginalZone

Intra/TxnBcl-6EBF1FoxO1IkarosPax5

Intra/TxnEBF1Notch2Pax5

Intra/TxnCBF1Pax5Spi-B

Pan MarkersCD19 CD20 CD22CD70hCD79α/β Igκ/λ

4

B Cell Markers

SurfaceCD1dCD5low CD9CD21/CD35high

CD23low/neg

CD24 (HAS)low

CD36CD81CD180 (RP105)FcRL3IgDlow/neg

IgMhigh SurfaceCD9CD16/32CD19low

CD81CD138IgG

SurfaceCD45R (B220)low

CD267 (TACI)CD269 (BCMA)IgG

Memory

SurfaceCD19CD81CD95GL7IgG

SurfaceCD20CD21/CD35low/neg

CD22CD23CD24 (HSA)low

CD25hCD36hCD40hCD69h

CD80hCD81CD86hCD180 (RP105)CD252 (OX40 Ligand)hIgDhigh

IgMlow/int

Follicular

Germinal Center

MarginalZone

Mouse

Pan MarkersCD20CD21/CD35low/neg

CD22CD23CD24 (HSA)low

CD25hCD36hCD40hCD69hCD80hCD81CD86hCD180 (RP105)CD252 (OX40 Ligand)h IgDhigh

IgMlow/int

Intra/TxnAIDBach2Bcl-6IRF8Pax5

Intra/TxnBlimp1IRF4XBP-1 Intra/Txn

CBF1Spi-B

Intra/TxnEBF1Notch2

Intra/TxnBcl-6EBF1FoxO1IkarosPax5

PlasmaCell

5 h = Up-regulated i = Down-regulated = Subset

SecretedIFNγIL-2 TNFαTNFβ (LTα)

SecretedIL-21

SurfaceCD183 (CXCR3) CD185 (CXCR5) CD278 (ICOS) CD279 (PD-1)

Intra/Txn BATFBcl-6c-MafIRF4STAT3

SecretedAmphiregulin IL-4IL-5 IL-13

SecretedIL-10TGFβ

SurfaceCD25CD39CD73CD101CD121aCD121b

CD137 (4-1BB)CD152 (CTLA-4)CD357 (GITR/AITR)GARPhLAPhTIGIT

SurfaceCD184 (CXCR4)CD194 (CCR4)CD198 (CCR8)CD294 (CRTH2)CD365 (TIM1)IL-25R (IL-17RB)IL-33R (ST2)

SurfaceCD121aCD161CD194 (CCR4)CD196 (CCR6) CD360 (IL-21R)CD212 (IL-12β1)IL-23R

Intra/TxnBATF GATA-3IRF4STAT6

SurfaceCD94CD119 (IFNγR1)CD183 (CXCR3)CD186 (CXCR6)CD191 (CCR1)CD195 (CCR5)CD212 (IL-12Rβ1)CD218a (IL-18Rα)CD254 (RANKL)CD366 (TIM3)

SecretedGM-CSFIL-17AIL-17AFIL-17FIL-21IL-22

Th1

Th2

Th17

Treg

Tfh

Intra/Txn STAT1STAT4T-bet

Intra/TxnAHRBATFc-MafIκBζ IRF4RORαRORγtSTAT3

Intra/Txnc-RelEosFoxp3HeliosSTAT5

CD4 T Cell MarkersHuman

6

Pan MarkersCD2CD3CD4CD5CD7CD25hCD27CD28CD45RA (naïve)CD45RO (memory)CD62L (naïve:high, effector:low, memory:high)CD69hCD127 (IL7Rα)CD134 (OX40)hCD137 (4-1BB)hCD152 (CTLA-4)hCD154 (CD40L)hCD272 (BTLA)hCD279 (PD-1)h

CD4 T Cell Markers

7

Intra/Txn BATF Bcl-6c-MafIRF4STAT3

SecretedAmphiregulinIL-4IL-5IL-13

SecretedIFNγIL-2TNFαTNFβ (LTα)

Intra/TxnSTAT1STAT4T-bet

SurfaceCD184 (CXCR4)CD194 (CCR4)CD198 (CCR8)CD294 (CRTH2)CD365 (TIM1)IL-25R (IL-17RB)IL-33R (ST2)

SurfaceCD94CD119 (IFNγR1)CD183 (CXCR3)CD186 (CXCR6)CD191 (CCR1)

SecretedIL-21

SecretedIL-10TGFβ

Intra/Txnc-RelEosFoxp3HeliosSTAT5

SecretedGM-CSFIL-17AIL-17AFIL-17FIL-21IL-22

Intra/TxnAHRBATFc-MafIκBζIRF4RORαRORγtSTAT3

Intra/TxnBATF GATA-3IRF4STAT6

Tfh

Treg

Th17

Th2

Th1

SurfaceCD194 (CCR4)CD196 (CCR6)CD121aCD212 (IL12β1)CD360 (IL-21R)IL-23R

SurfaceCD185 (CXCR5)CD278 (ICOS)CD279 (PD-1)

Mouse

SurfaceCD25 CD137 (4-1BB)CD39CD73CD101CD121aCD121bCD152 (CTLA-4)CD304 (Neuropilin-1)CD357 (GITR)FR4GARPhLAPhTIGIT

Pan MarkersCD3CD4CD5CD7CD25hCD27CD28CD44hCD62L (naïve:high, effector:low, memory:high)CD69hCD127 (IL7Rα)CD134 (OX40)hCD137 (4-1BB)hCD152 (CTLA-4)hCD154 (CD40L)hCD272 (BTLA)hCD278 (ICOS)hCD279 (PD-1)h

CD195 (CCR5)CD212 (IL-12Rβ1)CD218a (IL-18Rα)CD254 (RANKL)CD366 (TIM3)

h = Up-regulated i = Down-regulated = Subset

CD8 T Cell MarkersHuman

SurfaceCD197 (CCR7)CD127 (IL7Rα)CD27CD45RACD62L

SurfaceCD25hCD69hCD30CD122hCD137 (4-1BB)CD134 (OX40)

CD223 (LAG-3)CD272 (BTLA)CD278 (ICOS)CD279 (PD-1)CD366 (TIM3)KLRG1

SurfaceCD45ROKLRG1

SurfaceCD27CD28CD45ROCD62LCD127 (IL7Rα)CD197 (CCR7)

Intra/TxnEomesint

T-betint

SecretedGranzyme BIFNγIL-2PerforinTNFα

SecretedCCL3 (MIP-1α)CCL4 (MIP-1β)CCL5 (RANTES)Granzyme BIFNγIL-2PerforinTNFα

Intra/TxnT-bet

Intra/TxnEomesint

T-betint

Naïve

Effector

Effector Memory

Pan MarkersCD2CD3CD5CD7CD8CD25hCD27CD28

CentralMemory

8

CD8 T Cell Markers

Mouse Intra/TxnEomesint

T-betint

SecretedGranzyme BIFNγIL-2PerforinTNFα

SecretedCCL3 (MIP-1α)CCL4 (MIP-1β)CCL5 (RANTES)Granzyme B

IFNγIL-2PerforinTNFα

SurfaceCD25hCD30CD44CD69hCD122h

CD134 (OX40)CD137 (4-1BB)CD223 (LAG-3)CD272 (BTLA-4)CD278 (ICOS)CD279 (PD-1)CD366 (TIM3)KLRG1

Intra/TxnBlimp1Id2T-bet

Intra/TxnEomesint

T-betint

Naïve

Effector

CentralMemory

Pan MarkersCD3CD5CD8CD27CD28

SurfaceCD62LCD127 (IL-7Rα)CD197 (CCR7)CD183 (CXCR3)

SurfaceCD44CD57KLRG1Effector

Memory

SurfaceCD44CD62LCD127 (IL-7Rα) CD197 (CCR7)


Dendritic Cell MarkersHuman

PlasmacytoidDendritic Cell

Conventional Dendritic Cell

SecretedIDOIL-1βIL-6IL-8IL-12IL-15IL-23

SecretedIFNαIFNβ

Intra/TxnCD287 (TLR7)CD289 (TLR9)E2-2IRF8Intra/Txn

CD289 (TLR9)

SurfaceCD85g (ILT7)CD123CD303 (BDCA-2)CD304 (BDCA-4)

SurfaceCD1aCD1bCD1c (BDCA-1)CD11cCD14iCD40hCD49dCD141 (BDCA-3) CD197 (CCR7)CD205 (DEC-205)CD207 (Langerin)CD209 (DC-SIGN)CD273 (B7-DC)CD282 (TLR2)CD284 (TLR4)CD304 (BDCA-4)CD369 (Dectin-1)

10

Pan MarkersCD80hCD83CD86hMHCIIh

Dendritic Cell Markers

Mouse

PlasmacytoidDendritic Cell

SecretedIDOIL-1βIL-6IL-8IL-12IL-15IL-23

SecretedIFNαIFNβ

Intra/TxnCD287 (TLR7)CD289 (TLR9)E2-2IRF8

Intra/TxnCD289 (TLR9)

Pan MarkersCD11c CD80h CD86h MHCIIh

SurfaceCD45R (B220)CD317 (BST2,PDCA-1)Siglec-H

Surface33D1CD4CD8 CD11blow CD40hCD83CD197 (CCR7)CD205 (DEC-205)CD207 (Langerin) CD209 (DC-SIGN)CD273 (B7-DC)CD369 (Dectin-1)

Conventional Dendritic Cell


SurfaceCD31CD34CD54 (ICAM-1)CD61 (Integrinβ3)CD62E (E-Selectin)CD105 (Endoglin)CD106 (VCAM-1)hCD144 (VE-Cadherin)CD146CD202b (Tie2)CD309 (FLK1)Podoplanin

Endothelial Cell MarkersHuman

12

Mouse

Endothelial Cell Markers

SurfaceCD31 (PECAM-1)CD34CD54 (ICAM-1)CD61 (Integrinβ3)CD62E (E-Selectin)CD105 (Endoglin)CD106 (VCAM-1)hCD144 (VE-Cadherin)CD146CD202b (Tie2)CD309 (FLK1)PodoplaninVEGF Receptor 3


Human

Granulocyte Markers

Intra/TxnCD281 (TLR1)CD289 (TLR9)

SurfaceCD9CD15CD24CD35CD43CD64

CD116CD123CD125CD126CD244FcεR1

Eosinophil

Neutrophil

Mast

Intra/TxnC/EBPαCD281 (TLR1)CD289 (TLR9)GATA2

SurfaceCD10CD15CD17CD24CD35CD43CD66aCD66bCD66cCD66dCD89CD93

CD112 CD114CD116CD157CD177CD181 (CXCR1)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)

SurfaceCD9CD15CD24CD35CD43CD64CD116

CD117 (c-kit)CD123CD125CD126FcεR1IL-33R (ST-2)

Pan MarkersCD11bCD13CD15CD32CD33

SurfaceBasophil MarkerCD9CD11aCD13CD16CD25CD33CD38CD43CD88CD123CD125

CD154CD192CD203cCD218 (IL-18R)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)CD294FcεR1

Basophil

SecretedMPO

Human

14

Granulocyte Markers


Mouse

SurfaceCD10CD15CD17CD24CD35CD43CD66aCD66bCD66d

CD89CD93 CD112 (Nectin-2)CD114 (G-CSFR)CD116CD157CD177CD181 (CXCR1)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)

SurfaceCD9CD15CD24CD35CD43CD64CD116CD117 (c-kit)CD123CD125CD126FcεR1IL-33R (ST2)

SurfaceCD9CD11aCD13CD25CD33CD38CD43CD88 (C5a Receptor)

CD123CD125CD154 (CD40 Ligand)CD192 (CCR2)CD218 (IL-18 Receptor)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)CD294 (CRTH2)FcεR1

Intra/TxnCD281 (TLR1)CD289 (TLR9)

SurfaceCD9CD15CD24CD35 CD43 CD64

CD116CD123CD125CD126CD170CD244FcεR1

Mast

Neutrophil

Pan MarkersCD11bCD16/CD32Gr-1 (Ly6G)

Eosinophil

Basophil

Intra/TxnCD281 (TLR1)CD289 (TLR9)C/EBPαGATA-2

SecretedMPO

Macrophage/Monocyte MarkersHuman

Monocyte

M1 Macrophage

M2 Macrophage

SurfaceCD11c CD14CD33

SurfaceCD163CD206 (MMR)CD209 (DC-SIGN)FcεR1

Intra/Txn IRF5STAT1

Intra/TxnIRF4STAT6

SecretedIFNγIL-1αIL-1βIL-6IL-12IL-23TNFα

SecretedIDOIL-10TGFβ

SurfaceCD16CD16/CD32CD32CD64CD80CD86CD369 (Dectin-1) Mer (MerTK)MHCII

Pan MarkersCD11bCD15CD33CD40CD63CD68 (mature)CD80hCD85CD86hCD105hCD115CD169CD195 (CCR5)CD282 (TLR2)CD284 (TLR4)CD354 (Trem-1)CXCL10CXCL11CXCL9Mature Macrophage MarkerMIP-2α (CXCL2)

16

Macrophage/Monocyte Markers


Mouse

Pan MarkersCD11bCD16/CD32CD40CD64CD68CD107 (Mac3)CD115CD282 (TLR2)CD284 (TLR4)F4/80Galectin-3 (Mac2)GITRLLy6G (Gr-1)MHC Class IIh

SecretedArginaseIDOIL-10TGFβ

Intra/TxnIRF4 STAT6

Intra/TxnIRF5NOS2STAT1

SecretedIFNγIL-1IL-6IL-12IL-23TNFα

M2 Macrophage

M1 Macrophage

Monocyte

SurfaceCD14 CD16/CD32CD32CD64CD80

CD86CD204CD369 (Dectin-1)Mer (MerTK)MHCII

SurfaceCD14CD163CD204CD206 (MMR)CD209 (DC-SIGN)FcεR1

SurfaceLy6c

SurfaceCD9CD23CD31CD36CD41CD42aCD42bCD42cCD42dCD49fCD51

CD60aCD61CD84CD92CD110CD147CD151CD173CD226GARPLAP

Megakaryocyte/Platelet MarkersHuman Megakaryocyte

Platelet

SurfaceCD41CD42aCD42bCD42cCD42dCD49fCD51CD61CD110CD112CD123

18


Megakaryocyte/Platelet Markers

Mouse

SurfaceCD9 CD31 CD41 CD42b CD51 CD61 CD62PhLAP

SurfaceCD9 CD41 CD61 CD62Ph

Platelet

Megakaryocyte

HumanNK

ILC2

ILC1

ILC3

LTi

SecretedGranulysinGranzyme AGranzyme BGranzyme KIFNγIL-10PerforinTNFα

SurfaceCD11bCD16CD56CD69 hCD94CD122CD161CD244CD226 (TIGIT) CD314 (NKG2D)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)CD158 family (KIRs)

SurfaceCD56CD103CD183 (CXCR3)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)Linneg

SecretedCCL3 (MIP-1α)IFNγ

SecretedIL-4IL-5IL-9IL-13Amphiregulin

SecretedIL-17AIL-17AFIL-17FIL-22

SecretedIL-17LTβTNFβ (LTα)

Intra/TxnE4BP4EomesGATA-3Id2Runx1T-betTOX

Intra/TxnId2Tbet

Intra/TxnArginase-1GATA-3Gfi1Id2RORαTCF1

Intra/TxnAHRId2RORγtT-betTCF1

Intra/TxnAHRId2RORγtRunx1TOX

SurfaceCD25CD45CD117CD127 (IL-7Rα)CD161CD184 (CXCR4)CD186 (CXCR6)CD199 (CCR9)

CD278 (ICOS) CD294 (CRTH2)IL-25R (IL-17RB)IL-33R (ST2)Linneg

TSLP Receptor

SurfaceCD56CD117CD127 (IL-7Rα)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)IL-23R Linneg

SurfaceCD7CD25CD117CD127 (IL-7Rα)CD161CD196 (CCR6)IL-23RMHCII

NK/ILC Markers

20

NK/ILC Markers

Mouse

ILC3

ILC2

LTi

NK

SecretedIL-17AIL-17AFIL-17FIL-22

SecretedAmphiregulinIL-4IL-5IL-9IL-13

SecretedIL-17LTβTNFβ (LTα)

SecretedIFNγCCL3 (MIP-1α) Secreted

Granzyme A Granzyme BGranzyme KIFNγ

IL-10PerforinTNFα

Intra/TxnAHRId2RORγtT-betTCF1

Intra/TxnAHRId2RORγtRunx1TOX

Intra/TxnArginase-1GATA-3Gfi1Id2RORαTCF1

Intra/TxnId2Tbet

Intra/TxnE4BP4EomesGATA-3Id2Runx1T-betTOX

SurfaceCD103CD183 (CXCR3)CD335 (NKp46)Linneg

Ly-6A/E (Sca-1)

SurfaceCD117CD127 (IL-7Rα)CD196 (CCR6) CD335 (NKp46)IL-23RLinneg

SurfaceCD11bCD16CD25hCD49b (DX5)CD94CD122

CD161c (NK1.1)CD226CD314 (NKG2D)CD335 (NKp46)Ly-49 FamilyTIGIT

SurfaceCD4CD25CD117CD127 (IL-7Rα)CD185 (CXCR5)CD186 (CXCR6)CD196 (CCR6)IL-23RMHCII

SurfaceCD25CD117CD127 (IL-7Rα)CD184 (CXCR4)CD186 (CXCR6)CD199 (CCR9)CD278 (ICOS)CD294 (CRTH2)IL-25R (IL-17RB)Linneg

Ly-6A/E (Sca-1)IL-33R (ST2)TSLP Receptor

ILC1


Pan MarkersCD3

NKT

γδ T Cell

SecretedIL-4hIL-10hIL-13hIFNγhTNFαh

SecretedGM-CSFGranzyme BIFNγIL-4IL-5IL-17APerforinTNFα

Intra/TxnPLZFId2

SurfaceCD4 CD8 CD16CD56CD69CD160TCR Vα24

SurfaceCD5CD16CD27CD28CD45RACD56CD57CD62L

CD69CD70hCD107aCD314 (NKG2D)γδ TCRTCR Vδ1TCR Vδ2TCR Vδ3

NKT/γδ T Cell MarkersHuman

22

NKT/γδ T Cell Markers


Mouse

NKT

Intra/TxnPLZFEgr2HEBHobit

SurfaceCD4CD8CD44hCD49bCD94CD160CD183 (CXCR3)CD184 (CXCR4)CD186 (CXCR6)CD314 (NKG2D)DX5Ly-49 NK1.1 (on C57BL/6)TCR Vα14

SecretedIFNγhIL-4hIL-10hIL-13hIL-17hIL-21hIL-22hTNFαh

Pan MarkersCD3

γδ T

Cell

SecretedGranzyme BIFNγIL-4IL-5IL-17APerforinTNFα

Intra/TxnEomes RORγtT-bet

SurfaceCD25hCD27CD28CD44CD45R (B220)hCD45RBCD62LCD69hCD71hCD103CD122CD127 (IL-7Rα) CD150CD196 (CCR6)γδ TCRIL-1R1NK1.1 (on C57BL/6)TCR Vγ1TCR Vγ4TCR Vγ5TCR Vγ6TCR Vγ7

Stem Cell MarkersHuman

HSC

CMP

CLP

Intra/TxnIkarosPU.1

Intra/TxnGATA-2TdT

Intra/TxnAiolosc-mybGATA-3PU.1TdT

SurfaceCD38low/neg

CD59CD133CD135 (Flt3)CD338Linneg

SurfaceCD33CD45RACD123low

CD131CD135 (Flt3)CD173CD174Linneg

SurfaceCD7CD38CD45RACD90low

CD110CD117 (c-kit)low

CD127 (IL-7Rα)HLA-DRLinneg

Pan MarkersCD34CD117 (c-kit)CD164

24

Stem Cell Markers

Mouse

HSC

CMP

CLP

Intra/TxnIkarosPU.1

Intra/TxnAiolosc-mybGATA-3PU.1TdT

SurfaceCD34CD123 (IL-3R)Linneg

SurfaceCD34CD43CD135 (Flt3)CD127 (IL-7Rα)Linneg

Intra/TxnGATA-2TdT

SurfaceCD38low/neg

CD59CD117 (c-kit)CD133 (Prominin-1)CD135 (Flt3)CD150 (SLAM)Linneg

Ly-6A/E (Sca-1)


Other Cell Type MarkersHuman

26

CD24 CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) Cytokeratin

CD45neg CD51 CD61 CD235a/Glycophorin

CD10 CD29 CD47 CD81 CD91 CD121a CD140a/PDGFRa CD140b/PDGFRb Vimentin

CD6 CD24 CD90 CD143CD166 CD171 CD200 CD230 (Prion Protein) CD271 (NGFR) CD304 (Neuropilin) Nestin

CD10 CD34 CD157 Podoplanin/p38 Stro-1

Erythrocytes Fibroblasts NeuronsEpithelialCells

StromalCells

+

Erythrocytes Fibroblasts NeuronsEpithelialCells

StromalCells

Other Cell Type Markers

Mouse

CD24 CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) Cytokeratin

CD24 CD45neg CD51 CD61 Ter119

CD10 CD29 CD47 CD81 CD91 CD121a CD140a/PDGFRa CD140b/PDGFRb Vimentin

CD6 CD24 CD90 CD143 CD166 CD171 CD200 CD230 (Prion Protein) CD271 (NGFR) CD304 (Neuropilin) Nestin

CD10 CD34 CD157 Podoplanin/p38 Stro-1


6

Human CD Antigens

6

Antigen Name Alternative Name MW Distribution Function

CD1a T6, Leu-6, R4, HTA1 49kD cortical thymocytes, Langerhans cells, DC antigen presentation, w/ β2m

CD1b R1, T6 45kD cortical thymocytes, Langerhans cells, DC antigen presentation, w/ β2m

CD1c BDCA-1, R7, T6, M241 43kD cortical thymocytes, Langerhans cells, DC, B subset antigen presentation, w/ β2m

CD1d R3 49kD intestinal epith, B subset, monolow, DC antigen presentation, w/ β2m

CD1e R4 28kD DC antigen presentation, w/ β2m

CD2 T11, LFA-2, SRBC-R 50kD thymocytes, T, NK CD58 ligand, adhesion, T cell activation

CD2R T11-3 50kD Tact activation-dependent form of CD2

CD3γ, CD3δ T3 20, 25kD T, thymocyte subsetw/ TCR, TCR surface expression/signal transduction

CD3ε T3 20kD T, thymocyte subsetw/ TCR, TCR surface expression/signal transduction

CD4 T4, Leu3a 55kD thymocyte subset, T subset, mono, macMHC class receptor, HIV receptor, T cell differentiation/activation

CD5 T1, Tp67, Leu1, Ly-1 67kD thymocytes, T, B subset, B-CLLCD72 receptor, TCR or BCR signaling, T-B interaction

CD6 T12 100-130kD thymocytes, T, B subsetCD166 receptor, T cell differentiation/ costimulation

CD7 Leu9, gp40 40kD hematopoietic progenitors, thymocytes, T, NK T costimulation

CD8a T8, Leu-2, Ly-2 32-34kD thymocyte subset, T subset, NKMHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation/activation

CD8b Lyt-3 30-32kD thymocyte subset, T subset

CD9 p24, MRP-1, DRAP-27 22-27kDpre-B, eosinophils, basophils, platelets, Tact, and neurons and glial cells in the peripheral nervous system

cellular adhesion and migration

CD10 CALLA, NEP, gp100 100kD B precursors, T precursors, neutrophilszinc-binding metalloproteinase, B cell development

CD11a LFA-1, integrin αL 180kD lymph, gran, mono, macCD11a/CD18 receptor for ICAM-1,-2,-3, intercellular adhesion, T costimulation

CD11b Mac-1, integrin αM 170kD myeloid cells, NK binds CD54, ECM, iC3b

CD11cp150, 95, CR4, integrin αX, LeuM5

150kDB cells, dendritic cells, granulocytes, leukemia cells, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, T cells

binds CD54, fibrinogen and iC3b

CD12 90-120kD mono, gran, platelets

CD13 Aminopeptidase N, APN, GP150 150-170kDmono, gran, some macrophages, and connective tissue

zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains

28

Human CD Antigens

29


CD14 LPS-R 53-55kD mono, mac, Langerhans cells, granlow receptor for LPS/LBP, LPS recognition

CD153-FAL, X-hapten, LeX antigen, SSEA-1

gran, neutrophils, eosinophils, mono adhesion

CD15s Sialyl Lewis Xneutrophils, eosinophils, mono, memory helper T, Tact

and B, NK, HEVCD62L and CD62P ligand, adhesion

CD15u Sulfated Lewis X myeloid subset adhesion

CD16a FcγRIIIA 50-65kD neutrophils, mac, NKcomponent of low affinity Fc receptor, phagocytosis and ADCC

CD16b FcγRIIIB 48kD neutrophilscomponent of low affinity Fc receptor, phagocytosis and ADCC

CD17 lactosylceramide neutrophils, mono, platelets lactosyl ceramide

CD18 Integrin β2, ITGB2 95kD broad, all leukocytes w/ CD11a, b & c, adhesion

CD19 B4 95kD B, FDCcomplex w/ CD21and CD81, BCR coreceptor, B cell activation/ differentiation

CD20 B1, Bp35, Ly-44 33-37kD B, T subset B cell activation

CD21 C3DR, CR2, EBV-R110, 145kD

B, FDC, T subsetcomplement C3d and EBV receptor, complex w/ CD19 and CD81, BCR coreceptor

CD22 BL-CAM, Siglec-2, Leu-14 150kD B adhesion, B-mono, B-T interactions

CD23 FcεRII, BLAST-2 45kD B, activated mac, eosinophils, FDC, plateletsCD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction

CD24 BA-1, HSA, Heat-Stable Antigen 35-45kDthymocytes, erythrocytes, peripheral lymph, myeloid, B-lineage cells

binds P-selectin

CD25 Tac, p55 55kD Tact, Bact, lymph progenitorsIL-2Rα, w/ IL-2Rβ and γ to form high affinity complex

CD26 DPP IV, Ta1 110kD thymocyte subset, Tact, soluble form dipeptidyl peptidase, T costimulation, HIV entry

CD27S152, S152. LPFS2, T14, TNFRSF7, Tp55

50-55kD medullary thymocytes, T, B subset, NK subset CD70 receptor, T costimulation

CD28 Tp44, T44 44kD most T, thymocytes, plasma cells CD80, CD86 receptor, T costimulation

CD29Integrin β1, platelet GPIIa, MSK12, VLAB

130kDlymph, mono, granlow, platelets, mast cells, fibroblasts, endoth, nerve, connective tissue

w/ CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM

CD30 Ki-1, Ber-H2, TNFRSF8105-120kD

Bact, T and NK, Reed-Sternberg cells, anaplastic large cell lymphoma

CD153 receptor, lymph proliferation/ apoptosis

CD31 PECAM-1, endocam 130-140kD mono, platelets, gran, endoth, lymph subset CD38 receptor, adhesion, signal transduction

Human CD AntigensAntigen Name Alternative Name MW Distribution Function

CD32 FcγRII 40kD mono, gran, B, plateletslow affinity Fc receptor for aggregated Ig and immune complexes

CD33 p67, Siglec-3 67kD myeloid progenitors, mono, gran, DC, mast cells, Tact adhesion

CD34 MY10, Mucosialin, gp 105-120105-120kD

hematopoietic precursors, capillary endoth, embryonic fibroblasts

stem cell marker, adhesion, CD62L receptor

CD35 CR1 250kDerythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset

complement receptor 1, binds C3b and C4b, adhesion, phagocytosis

CD36GPIV, GPIIIb, fatty acid translocase, SCARB3, GP88

88kD platelets, mono, mac, endoth, early erythrocytes ECM receptor, adhesion, phagocytosis

CD37 gp40-52 40-52kD B, Tlow, granlow, mono, DC signal transduction

CD38 T10, cyclic ADP ribose hydrolase 45kDvariable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact

ecto-ADP-ribosyl cyclase, cell activation, cyclase & hydrolase activity

CD39 ENTPD-1, Gp80, EC3.6.1.5 78kD NK, mac, Langerhans cells, DC, Bact, TregB cell adhesion, protects activated cells from lysis, ecto-apyrase

CD40 Bp50, TNFRSF5 48kD B, mono, mac, FDC, endoth, T subsetCD154 receptor, B differentiation/ costimulation, isotype-switching, rescues B cells from apoptosis

CD41 gpIIb, αIIβ integrin, ITGA2B 22, 125kD platelets, megakaryocytesw/ CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation

CD42a Glycoprotein IX, GP9 22kD platelets, megakaryocytescomplex w/ CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices

CD42b GPIba 145kD platelets, megakaryocytescomplex w/ CD42a, c and d, binds to vWF and thrombin, platelet adhesion/activation

CD42c GPIbb 24kD platelets, megakaryocytes complex w/ CD42a, b, d

CD42d gpV 82kD platelets, megakaryocytes complex w/ CD42a-c

CD43 Leukosialin, sialophorin 115-135kD leukocytes, except resting B, plateletslow inhibition of T cell interaction, CD54R, adhesion

CD44

H-CAM, Pgp-1, Hermes Ag, lymphocyte homing receptor, ECM-III, Hyaluronate receptor, HUTCH-1

80-95kDhematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis

binds hyaluronic acid, adhesion

CD44std (SFF-2) CD44 variant 1-10CD44 variants heterogeneous expression, constitutively on epith, mono, up-regulated on activated leukocytes

adhesion, metastasis

30


CD44std (SFF-304)

CD44var (v4)

CD44var (var10)

CD44var (v7-v8)

CD44 (v6)

CD44 (v3)

CD44 (v6)

CD44 (v5)

CD44 (v7)

CD45LCA, PTPRC, Protein tyrosine phosphatase receptor type C

180-240kD

hematopoietic cells, multiple isoforms from alternative splicing

tyrosine phosphatase, enhanced TCR & BCR signals

CD45R B220

CD45RA T200, gp220205-220kD

B, T subsetnaive, mono exon A isoforms of CD45

CD45RB LCA190-220kD

B, T subset, mono, mac, gran exon B isoforms of CD45

CD45RC190-220kD

B, T subset, NK exon C isoforms of CD45

CD45RO T200, gp180, UCHL1 180kD Tact, memory T, B subset, mono, mac, granisoform of CD45 lacking A, B, C exons, ligand for CD22

CD46MCP, Membrane Cofactor Protein

56, 66kD nucleated cellsmembrane cofactor protein, binds C3b & C4b allowing degradation by Factor I, measles virus receptor

CD47 IAP, integrin associated protein 47-52kDhematopoietic cells, epith, endoth, fibroblasts, other tissues

leukocyte adhesion, migration, activation, thrombospondin receptor

CD47R MEM-133 120kDnew designation for CDw149, similar distribution as CD47 but dimmer

CD48 Blast-1, BCM1, Sgp-60, SLAMF2 45kD broad, all leukocytes cell adhesion

CD49a VLA-1, Integrin α1 210kD Tact, monointegrin α1, adhesion, CD49a/CD29 binds collagen and laminin

CD49b VLA-2, Integrin α2 165kD B, mono, platelets, Tact, megakaryocytesintegrin α2, adhesion, CD49b/CD29 binds collagen and laminin

31

Human CD Antigens


CD49c VLA-3, Integrin α3 125kD B and Tlow, most adhesive cell linesintegrin α3, adhesion, CD49c/CD29 binds laminin, fibronectin and collagen

CD49d VLA-4, Integrin α4 150kD T, B, NK, thymocytes, mono, eosinophils, mast, DCintegrin α4, adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1

CD49e VLA-5, Integrin α5 25, 135kD thymocytes, T, mono, platelets, early and Bactintegrin α5, adhesion, CD49e/CD29 binds fibronectin

CD49f VLA-6, Integrin α6 125kDmemory T, thymocytes, mono, platelets, megakaryocytes, epith

integrin α6, adhesion, CD49f/CD29 binds laminin

CD50 ICAM-3 110-120kD hematopoietic, endoth, epidermal Langerhans cells adhesion, costimulation

CD51 Vitronectin receptor, integrin αV 24, 125kD plateletslow, endoth, osteoblasts, melanomasintegrin αv, adhesion, CD51/CD61 binds vitronectin, vWF, fibrinogen and thrombospondin

CD52 CAMPATH-1, HE5 21-28kD thymocytes, T, B (not plasma cells), mono, mac unknown

CD53 OX-44 35-42kD leukocytes, DC, osteoblasts, osteoclasts signal transduction

CD54 ICAM-1 90-110kD endoth, mono, lymph (high upon activation)receptor for CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1) and rhinovirus

CD55 DAF, Decay accelerating factor 60-70kD hematopoietic, endoth, soluble in plasma binds C3b, complement regulation

CD56 NCAM, Leu-19, NKH-1 175-185kDNK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias

adhesion

CD57 HNK-1, Leu-7 110kD NK subset, T subset

CD58 LFA-3 55-70kD hematopoietic, non-hematopoietic cells CD2 receptor, adhesion

CD59

Protectin, H19, 1F-5Ag, HRF, MAC-inhibitor protein, MAC-IP, membrane inhibitor of reactive lysis, MIRL

19kD hematopoietic, non-hematopoietic cellsbinds complement C8 and C9, blocks assembly of membrane attack complex

CD60a GD3 90-120kD T subset, platelets, thymic epith, astrocytes costimulation

CD60b 9-O-sialyl GD3 T subset, Bact

CD60c 7-O-sialyl GD3 T subset

CD61 GPIIIa, Integrin β3 105kD platelets, megakaryocytes, mac, endothintegrin β3, adhesion, CD41/CD61 or CD51/CD61 mediate adhesion to ECM

CD62E E-selectin, ELAM-1, LECAM-297, 107-115kD

endoth binds CD15s, cell rolling, metastasis

CD62L L-selectin, LECAM-1, LAM-1 74, 95kD B, naïve and memory T, mono, gran, NK, thymocytesCD34, GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling

Human CD Antigens

32


CD62P P-selectin, GMP-140, PADGEM 140kD activated platelets, endothCD162, CD15s receptor, adhesion, neutrophil rolling, platelet-neutrophil and platelet-mono interactions

CD63 LIMP, MLA1, LAMP-3 53kD activated platelets, mono, maclysosomal membrane protein, moves to cell surface after activation

CD64 FcγRI 72kD mono, mac, DC, Interferon or G-CSF activated granhigh affinity receptor for IgG, phagocytosis and ADCC

CD65VIM2, Ceramide-dodecasaccharide

gran, mono subset, myeloid leukemias CHO

CD65s VIM2 gran, mono, myeloid leukemias phagocytosis, CHO

CD66a BGP-1, NCA-160160-180kD

neutrophils, epith cell adhesion

CD66b CD67, CGM6, NCA-95 95-100kD gran cell adhesion, neutrophil activation

CD66c NCA 90kD neutrophils, colon carcinoma cell adhesion

CD66d CGM1 35kD neutrophils, gran putative role in cell adhesion and signaling

CD66e CEA180-200kD

colon epith, colon cancer cell adhesion

CD66f PSG, Sp-1 54-72kDpregnancy specific glycoprotein, placental syncytiotrophoblasts, fetal liver

immune regulation, protects fetus from maternal immune system

CD68 Macrosialin, gp110 110kDintracellularly in mono, mac, neutrophils, basophils, large lymph, mast cells, DC, myeloid progenitors, liver

scavenger receptor

CD69 AIM, VEA 28, 32kDTact, B, NK and gran, thymocytes, platelets, Langerhans cells

signal transduction

CD70 Ki-24, CD27L, TNFSF750, 70, 90, 160kD

Bact and Tact CD27 ligand, T and B cell costimulation

CD71 TfR, T9 95kD proliferating cells, reticulocytes, erythroid precursors transferrin receptor, iron uptake

CD72 Lyb-2 42kD B, FDC CD5, CD100 receptor, B proliferation

CD73 NT5E, Ecto-5'-nucleotidase 69kD B subset, T subset, FDC, epithecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion

CD74

Ii, invariant chain, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain

33, 35, 41, 43kD

B, mac, mono, Langerhans cells, DC, TactMHC class II traffic and function, binds MIF, maturation of follicular B cells

CD75 lactosamines 67, 85kD B subset, epith lactosamines, CHO

33

Human CD Antigens


CD75s siliated lactosamines B subset, T subseta-2,6-sialylated lactosamines (previously CDw75 and CDw76)

CD77 Gb3, Pk blood group 1kDgerminal center B, Burkitt’s lymphomashigh, follicular lymphomaslow

apoptosis, CHO

CD79a Iga, MB-1 33, 45kD B component of BCR, BCR surface expression and signal transduction

CD79b Igb, B29 37kD B component of BCR, BCR surface expression and signal transduction

CD80 B7, B7-1, BB1 60kD Bact and Tact, mac, DC binds to CD28, CD152, T costimulation

CD81 TAPA-1 26kDT, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas

complex w/ CD19 & CD21, signaling, T costimulation

CD82 R2, 4F9, C33, Kai1 50-53kD leukocytes, fibroblast, epith, endoth signal transduction

CD83 HB15 43kD Bact and Tact, DC, Langerhans cells dendritic cell marker

CD84 GR6, SLAMF5 73kD mono, platelets, B, T subset, mac subset putative role in adhesion, costim

CD85a LIR-3, ILT-5, HL-9, LILRB3 110kD mono signaling through FCg

CD85d LIR-2, ILT-4, MIR10, ILT8 110kD NK, mono, mac suppression of NK cell-mediated cytotoxicity

CD85g LIR4, ILT-7 55kD pDC signaling for cytokine production

CD85h LIR-7, ILT-1, LILRA2 53kD mono receptor for MHC class I antigens

CD85j LIR-1, ILT-2, MIR-7 110kD NK, DC, mono, T cells inhibitory receptor for MHC class I antigens

CD85k LIR-5, ILT-3, HM18, LILRB4 60kD DC, mac, mono, pDC thought to be an inhibitory receptor

CD86 B70, B7-2 80kD mono, DC, Bact and Tact binds to CD28, CD152, T costimulation

CD87 UPA-R 39-66kD gran, mono, NK, Tact, endoth, fibroblastsurokinase plasminogen activator receptor, inflammatory cell invasion, metastasis

CD88 C5aR 40kD gran, mono, DC C5a receptor, granulocyte activation

CD89 FcαR 55-75kD mono, mac, gran, neutrophils, B subset, T subsetIgA receptor, phagocytosis, degranulation, respiratory burst

CD90 Thy-1 25-35kD CD34+ hematopoietic subset, neuronshematopoietic stem cell and neuron differentiation, adhesion, signal transduction

CD91 α2MR 600kD mono, mac, neurons, fibroblasts receptor for α-2-macroglobulin

CD92 p70, CHTL1 70kD neutrophils, mono, platelets, endoth, fibroblasts putative ligand transporter

CD93 C1qRp 120kD neutrophils, mono, endoth clearance of apoptotic cells

CD94 KP43, KLRD1 43kD NK, T subset complex w/ NKG2, inhibits NK function

Human CD Antigens

34


CD95 Apo-1, Fas, TNFRSF6 45kD lymph (high upon activation), mono, neutrophils FasL (CD178) receptor, apoptosis

CD96 TACTILE 160kD NK, Tact adhesion of activated T and NK

CD97 BL-KDD/F1274, 80, 90kD

Bact and Tact, mono, gran

CD98 4F2, CD98hc 40, 80kD T, B, NK, gran, all human cell lines cellular activation

CD99 MIC2, E2 32kD leukocytes T cell activation, adhesion

CD99R E2 32kD T, NK, myeloid cells isoform of CD99

CD100 Sema4D 150kDhematopoietic cells except immature bone marrow cells, RBC and platelets

cell adhesion, cellular activation

CD101 V7, p126 120kD mono, gran, DC, Tact T cell activation

CD102 ICAM-2 55-65kD leuk, endoth binds CD11a/CD18, costimulation

CD103 HML-1, α6, integrin αE 25, 150kD intraepithelial lymph, lymph subset, activated lymphw/ integrin β7, binds E-cadherin, lymph homing/retention

CD104 β4 integrin 220kD epith, Schwann cells, keratinocytes, some tumor cellsw/ integrin α6 (CD49f), cell adhesion, differentiation, metastasis

CD105 Endoglin 95kD endoth, bone marrow subset, activated maccellular response to TGF-β1, adhesion, embryonic angiogenesis

CD106 VCAM-1 110kD activated endoth, FDCVLA-4 (CD49d/CD29) receptor, leukocyte adhesion, migration, costimulation

CD107a LAMP-1 110kD activated platelets, T, endoth, metastatic tumors a lysosomal membrane protein

CD107b LAMP-2 120kD activated platelets, T, endoth, metastatic tumors a lysosomal membrane protein

CD108 SEMA7A 80kD erythrocytes, lymphoblasts, resting lymphlow putative role in inflammation

CD109 Platelet specific Gov antigen 170kD Tact and platelets, CD34+ subset, endoth negative regulator of TGF-β in keratinocytes

CD110 TPO-R, C-mpl 82-84kD megakaryocytes, platelets, some CD34+ stem cellslowthrombopoietin receptor, megakaryocyte progenitor cell growth/differentiation

CD111 PRR1, Nectin-1 64-72kD stem cell subset, mac, neutrophils intercellular adhesion

CD112 PRR2, Nectin-2 64-72kDmono, neutrophils, CD34+ subset, megakaryocytes, endoth, epith

intercellular adhesion

CD113 PVRL3, Nectin3 83kD testis, placenta adhesion molecule that interacts with afadin

CD114 G-CSFR 95, 139kD myeloid progenitors, endoth myeloid differentiation/proliferation

CD115 M-CSFR, c-fms 150kD mono, mac, monocytic progenitors CSF-1R, monocytic differentiation/ proliferation

CD116 GM-CSFRa 70-85kD mono, gran, DC, endothw/ common b, myeloid differentiation/proliferation

35

Human CD Antigens


CD117 c-kit, SCFR 145kD hematopoietic progenitors, mast cellsSCF receptor, hematopoietic progenitor development/differentiation

CD118 LIFR, gp190 190kD epithelial cells in adult and embryomembrane-bound involved in signal transduction, soluble form inhibits activity of LIF

CD119 IFN-γRα 90-100kD mac, mono, B, T, NK, neutrophils, endoth IFN-γRα, w/ IFN-γ AF-1, host defense

CD120a TNFR-I, p55 50-60kD hematopoietic, non-hematopoietic cells receptor for both TNF-α and TNF-β

CD120b TNFR-II, p75 75-85kD hematopoietic, non-hematopoietic cells receptor for both TNF-α and TNF-β

CD121a IL-1R, type I 80kD dimly expressed on many cells binds IL-1α and IL-1β, IL-1 signaling

CD121b IL-1R, type II 60-70kD B, mac, mono, T subset binds IL-1α and IL-1β, negative signals

CD122 IL-2Rβ 75kD NK, T, B, mono IL-2Rβ and IL-15Rβ, signal transduction

CD123 IL-3R 70kDlymph subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes

IL-3Rα, w/ CDw131

CD124 IL-4R 140kDlymphlow, mono, hematopoietic precursors, fibrobroblast, epith

IL-4Rα, w/ CD132 or IL-13Rα, T cell growth/differentiation

CD125 IL-5R 60kD eosinophils, basophils IL-5Rα, w/ CDw131

CD126 IL-6R 80kD Bact and plasma cells, Leuk (maj)low, fibroblasts IL-6Rα, w/ CD130

CD127 IL-7R 65-75kD T, pro-B, down-regulated on Treg IL-7Rα, w/ CD132, B and T cell development

CD128 see CD181 & CD182

CD130 IL-6Rβ, gp130 130kD Bact and plasma cells, Leuk (maj)low, endoth IL-6Rβ, IL-6, IL-11, LIF, CNF signals

CD131 IL-3R common β 95-120kD mono, gran, early Bw/ a subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction

CD132 Common γ 64kD T, B, NK, mono, gransubunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction

CD133 AC133, prominin-like 1 120kDhematopoietic stem cell subset, epith, endoth, leukemias

unknown

CD134 OX-40 48-50kD Tact T cell activation, differentiation, apoptosis

CD135 Flt3/Flk2130-150kD

myelomonocytic, primitive B progenitorstyrosine kinase, binds FLT3 ligand, early lymph development

CD136 MSP-R, RON 180kD epith, CNS, PNS, hematopoietic subsetmigration, morphological change and proliferation of different target cells

CD137 4-1BB 30kD Tact T costimulation

CD138 Syndecan-1 80-150kDplasma cells, pre-B, basolateral surface of epith, neurons

receptor for ECM, cell morphology

CD139 228kD B, mono, gran, erythrocyteslow, FDC

Human CD Antigens

36


CD140a PDGFRa 180kD fibroblasts, smooth muscle & glial cells, chondrocytes binds PDGF A and B, tyrosine kinase receptor

CD140b PDGFRb 180kD fibroblasts, smooth muscle & glial cells, chondrocytes binds PDGF B, tyrosine kinase receptor

CD141 Thrombomodulin 100kD mono, neutrophils, endoth, smooth muscle cells initiation of protein C anticoagulant signal

CD142 Tissue Factor 45kD mono, endoth, keratinocytes, epith binds clotting factor VIIa, initiator of clotting

CD143 ACE 170kD endoth, epith, neurons, fibroblasts, activated macangiotensin converting enzyme, angiotensin II & bradykinin metabolism

CD144 VE-Cadherin, Cadherin-5 130kD endoth, stem cells adhesion, endothelium biology

CD145 90, 110kD endoth, some stromal cells

CD146 MUC18, S-endo 113-118kD endoth, melanomas, FDC, Tact adhesion

CD147Neurothelin, basoglin, EMMPRIN

28kD leukocytes, erythrocytes, platelets, endoth adhesion, T cell activation, thymocyte cycling

CD148 HPTP-eta240-260kD

gran, mono, DC, T (high upon activation) tyrosine phosphatase R Type III

CD150 SLAM 75-95kD T subset (high upon activation), B, DC, endothcostimulation, proliferation, Ig production, measles virus receptor, T & B cell activation

CD151 PETA-3 32kD endoth, megakaryocytes, platelets, epith cell adhesion

CD152 CTLA-4 33kD Tact and BCD80 and CD86 receptor, negative regulation of T cell costimulation

CD153 CD30L 40kD neutrophils, B, Tact and mac CD30 ligand, T costimulation

CD154 CD40L, gp39, TRAP 32-39kD Tact CD40 ligand, B and DC costimulation

CD155 PVR 80-90kD mono, mac, CD34+ thymocytes Polio virus receptor (PVR)

CD156a ADAM8 69kD neutrophils, mono leukocyte extravasation

CD156b TACE/ADAM 17 100kD broadcleaves membrane proteins (TNF, TGF-α) to generate soluble forms

CD156c ADAM10 98kDlymphoid organs, peripheral blood leukocyte, cartilage, chondrocytes and fetal liver

proteolytic cleavage of cell-surface molecules including Notch, TNF-α, APP and ephrin-A2

CD157 BST-1 42-45kD gran, mono, B progenitors, endothADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell growth

CD158a p58.1 50-58kD NK subset, T subsetinhibition of NK cell cytolytic activity, MHC class-I specific NK receptor

CD158b p58.2 50-58kD NK subset, T subsetinhibition of NK cell cytolytic activity, MHC class-I specific NK receptor

CD158f KIR2DL5 50-58kD NK subset, T subsetinhibition of NK cell cytolytic activity, MHC class-I specific NK receptor

37

Human CD Antigens


CD159a NKG2A 43kD T subset, NK w/ CD94, NK cell receptor

CD159c NKG2C 40kD NKw/ MHC class I HLA-E molecules, forms heterodimer with CD94

CD160 BY55 27kD NK subset, T subset costimulation

CD161 NKR-P1A 40kD T subset, NK NK cell-mediated cytotoxicity

CD162 PSGL-1 120kD mono, gran, most lymph CD62P, CD62L ligand, adhesion, rolling

CD162R PEN-5 110-140kD NK subset homing receptor for NK cells

CD163hemoglobin scavenger receptor, macrophage marker

130kD mono, mac, poss HSC clearance of hemoglobin

CD164 MGC-24 80kD hematopoietic progenitor cell-stromal cell interaction putative role in intracellular adhesion

CD165 AD2, gp37 42kD adhesion, thymocyte-thymic epith interaction putative role in intracellular adhesion

CD166 ALCAM 105kD neurons, mono, epith, fibroblasts, Tact CD6 ligand, adhesion

CD167a DDR1 120kD epith, myoblasts tyrosine kinase, adhesion to collagen

CD168 RHAMM 84-88kDmono, T subset, thymocyte subset, intracellularly in breast cancer cells

adhesion, tumor migration, metastasis

CD169 sialoadhesin, Siglec-1 185kD tissue mac subsetadhesion, cell-cell and cell-matrix interactions, binds CD227 on breast cancer cells and CD43 on T cells

CD170 Siglec-5, CD33-like2 140kD mac subset, neutrophils adhesion

CD171 L1200-210kD

CNS, PNS, glial cells, mono, T subset, B, DC, several human tumor cells

kidney morphogenesis, lymph node architecture, T costimulation, neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56, CD142, CD166, integrins

CD172a SIRPg 110kD mono, T subset, stem cells adhesion, complex w/ CD47

CD172b SIRPb, SIRB1 50kD mono and DC negative regulation of RTK-coupled signaling

CD172g SIRPg, SIRPB2 45-50kD mRNA: liver and at lower levels in many tissues binds CD47

CD173 Blood group H type 2 erythrocytes, stem cell subset, plateletsputative role in homing immature stem cells to bone marrow

CD174 Lewis Y stem cells subset, epith putative role as co-factor to pro-coagulant y

CD175 Tn stem cells subset CD175 precursor for ABO antigen

CD175s Sialyl-Tn erythroblasts, myeloid leukemias, carcinoma cells putative role in tumor metastasis

CD176 Thomson Friedrenreich Ag stem cell subset, carcinoma cells putative role in tumor metastasis

CD177 NB1 56-62kD neutrophil subset

Human CD Antigens

38


CD178 FasL, CD95L 38-42kD Tact, testis, neutrophil, mono, NK CD95 ligand, apoptosis, immune privilege, soluble form in serum

CD179a V pre B 16-18kD pro- and pre-B B cell differentiation/signaling, w/ IgM

CD179b Lambda 5 22kD pro- and pre-B B cell differentiation/signaling, w/ IgM

CD180 RP-105 95-105kD B subset, mono, DC B cell activation, LPS signaling, w/ MD-1

CD181 CXCR1, IL-8RA 39kD neutrophils, basophils, NK, T subset, monobinding of IL-8 induces chemotaxis of neutrophils, phospholipase D activation, repiratory burst

CD182 CXCR2, IL-8RB 40kD neutrophils, basophils, NK, T subset, mono binding of IL-8 induces chemotaxis of neutrophils

CD183 CXCR3 40kDeosinophils, Tact and NK, GM-CSF activated CD34+ progenitors

IP-10, Mig and I-TAC receptor, T cell recruitment to inflammatory sites, enhancement of Th1 response

CD184 CXCR4, fusin 45kD B, DC, T subset, mono, endothSDF-1 receptor, X4 HIV-1 coreceptor, inhibits chemotaxis & Ca flux induced by SDF1

CD185 CXCR5, BLR1 45kD mature B and Burkitt Lymphoma cellsw/ chemokine BLC, possible regulatory function in Burkitt Lymphomagenesis and/or B differentiation, activation of mature B

CD186 CXCR6, BONZO 40kD Tactreceptor for CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1

CD191 CCR1, MIP-1aR, RANTES-R 39kD T, mono, stem cell subsetbinds C-C type chemokines and transduces signal by increasing intracellular calcium ion levels

CD192 CCR2, MCP-1-R 40kDactivated NK and mononuclear phagocytes, T subset, B, endoth

binds MCP-1, MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection

CD193 CCR3, CKR3 45kDeosinophils, lower expression in neutrophils and mono, T subset

binds eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1d, alternative coreceptor w/ CD4 for HIV-1 infectiongg

CD195 CCR5 45kD mono, T subsetMIP-1a, MIP-1b and RANTES receptor, R5 HIV-1 coreceptor

CD196 CCR6, LARC receptor, DRY6 45kD T subset, B, DC subset binds MIP-3a/LARC

CD197 CCR7, EBI-1 45kD T subset, DC subset6Ckine and MIP-2b receptor, CCL19 & CCL21 receptor, T cell migration

CD198 CCR8, GPRCY6, TER1 50kD T, high expression in Th2, NK, monoallergic inflammation, alternative coreceptor with CD4 for HIV-1 infection

CD199 CCR9, GPR-9-6 43kD subset of memory T, lamina propria mononuclear cellsbinds SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection

CD200 OX-2 45-50kD thymocytes, endoth, B, Tact inhibition of immune response

39

Human CD Antigens


CD200R 48kD hematopoietic inhibitory receptor, inhibits TNFα secretion

CD201 EPC-R 50kD endoth subset activated protein C receptor

CD202b Tie2, Tek 150kD stem cells, endoth angiopoietin-1 receptor

CD203c NPP3/PDNP3, ENpp1, PD-1b130-150kD

basophils, mast cells, glioma cells, megakaryocytesectoenzyme, binding to and clearance of extracellular nucleotides

CD204 Macrophage scavenger-R 220kD mac endocytosis of macromolecules

CD205 DEC-205 205kD DC, thymic epith DC, thymic epith

CD206 macrophage mannose-R 180kD DC subset, mac, monophagocytosis and pinocytosis of mannose containing molecules

CD207 Langerin 40kD Langerhans cells endocytic receptor

CD208 DC-LAMP 70-90kD DCact, interdigitating DC putative role in sorting MHC Class II

CD209 DC-SIGN 44kD DC subset ICAM-3 receptor, HIV-1 binding protein

CD210 IL-10-R 90-110kD T, B, NK, mono, mac IL-10 receptor, signal transduction

CD212 IL-12Rβ1 100kD Tact and NKbinds IL-12 w/ high affinity, associates w/ IL-12 receptor β2

CD213a1 IL-13Rα1 65kD B, mono, fibroblasts, endoth binds IL-13 w/ low affinity, w/ CD124

CD213a2 IL-13Rα2 65kD B, mono binds IL-13 w/ high affinity

CD215 IL15RA, interleukin 15 receptor, α 28kD brain tissue high affinity receptor for IL-15

CD217 IL-17R 120kD broad IL-17 receptor

CD218a IL-18Rα, IL-1Rrp 70kD T, NK, DCs binds IL-18, activation of NF-κB

CD218b IL-18Rβ, IL18RAP 70kD T, NK and DCsheterodimeric receptor with IL-18Ra to enhance IL-18 binding

CD220 Insulin-R 140, 70kD broad insulin receptor

CD221 IGF-1 R 70, 140kD broadbinds IGF w/ high affinity, signaling, cell proliferation/ differentiation

CD222 IGF-II R, mannose-6 phosphate-R 250kD broad, 90-95% intracellularadhesion, tumor growth, a receptor for TGFβ-LAP, plasminogen, proliferin, truncated form (220kD) found in serum

CD223 LAG-3 70kD Tact and NK MHC class II ligand

CD224 GGT 27, 68kD leukocytes, stem cells maintain cellular redox

CD225 Leu-13 17kD broad B cell activation

CD226 DNAM-1, PTA-1, TLiSA1 65kD T, NK, mono, platelets, activated HUVECactivation of cell-mediated cytotoxicity, soluble form (50kD) found in normal serum

Human CD Antigens

40


CD227 MUC1, EMA 300kDepith, stem cell subset, FDC, mono, B subset, some myelomas

adhesion, signaling, binds CD169, CD54, & selectins

CD228 Melanotransferrin 80-95kD stem cells, melanomas iron transport, migration of endoth

CD229 Ly-9 95, 110kD T, B adhesion

CD230 Prion protein 35kD lymphocytes, monos w/ TSE

CD231 TALLA-1, A15 30-45kD T leukemias, neuroblastomas, brain neurons marker for T cell acute lymphoblastic leukemia

CD232 VESP-R 200kD broad

CD233 Band 3, SLC4A1 90kD erythrocytesanion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton

CD234 Duffy, DARC 35-45kD erythrocytes Duffy antigen chemokine receptor

CD235a Glycophorin A 36kD erythrocytes major glycoprotein of erythrocyte cell membrane

CD235b Glycophorin B 20kD erythrocytesmajor sialoglycoprotein of erythrocyte membrane maintain erythrocyte structure

CD236 Glycophorin C/D 32, 23kD erythrocytes, stem cell subset

CD236R Glycophorin C 32kD erythrocytes, stem cell subset

CD238 Kell 93kD erythrocytes, stem cell subset zinc endopeptidase

CD239 B-CAM 78-85kD erythrocytes, stem cell subset

CD240CE Rh30CE 30-32kD erythrocytes

CD240D Rh30D 30-32kD erythrocytes

CD241 RhAg, Rh50 50kD erythrocytes complex w/ CD47, LW, glycophorin B

CD242 ICAM-4 42kD erythrocytes adhesion, Landsteiner-Wiener blood group

CD243 MDR-1, p170, P-gp 180kDstem cells, small intestine, kidneystem cells, small intestine, kidney

ion pump

CD244 2B4, p38 70kD T subset, mono, basophils, NK, mast, eosinophils NK activation, CD48 ligand

CD245 p220/240220-240kD

gran, resting PBLs, platelets, mono, NK signal transduction, costim T & NK cells

CD246 ALK 80kDanaplastic T cell leukemias, small intestine, testis, brain, not on normal lymph

brain development, implicated in ALK lymphomas

CD247 TCRζ 16kD T, NK TCR complex subunit, coupling of antigen recognition to signalingCD248 TEM1, Endosialin 175kD endothelial tissue, stromal fibroblasts tumor progression and angiogenesis

CD249 Aminopeptidase A 160kD epith, endoth renin-angiotensin system

CD252 OX-40Ligand, gp34 34kD Bact, cardiac myocytes T costimulation

41

Human CD Antigens


CD253 TRAIL, Apo-2L, TL2, TNFSF10 32kD Tact, many tissues, B, NK death, binds Apo-2

CD254 TRANCE, RANKL, OPGL 35kD lymph node & BM stroma Tactbinds OPG and RANK, osteoclast differentiation, enhances DC to stimulate naïve-T proliferation, regulates Bcl-XL expression

CD256 APRIL, TALL-2 16kD mono, macbinds TACI & BCMA, B proliferation, induces cell death

CD257 BLyS, BAFF, TALL-1 31kD monoact, soluble formB cell growth factor & costimulator of Ig production, binds TACI & BCMA

CD258 LIGHT, HVEM-L 28kD Tact, immature DC binds LTBR, T proliferation, receptor for HVEM

CD261 TRAIL-R1, DR4 57kD Tact, peripheral blood leukocytescontains death domain, apoptosis via FADD & caspase-8, binds TRAIL

CD262 TRAIL-R2, DR5 60kD widely expressed, peripheral blood lymphocytescontains death domain, apoptosis via FADD and caspase-8, binds TRAIL

CD263 TRAIL-R3, DcR1, LIT 65kD peripheral blood lymphocytes receptor for TRAIL but lacks death domain

CD264 TRAIL-R4, TRUNDD, DcR2 35kD peripheral blood leukocytes binds TRAIL but contains truncated death domain

CD265 RANK, TRANCE-R, ODFR 97kD broad expression, DC binds TRANCE, osteoclastogenesis, T-DC interactions

CD266 TWEAK-R, FGF-inducible 14 14kD heart, placenta and kidney, HUVECTWEAK receptor, cell-matrix interactions and endoth growth and migration

CD267 TACI, TNFR SF13B 32kD B, Tact binds BAFF & APRIL

CD268 BAFFR, TR13C 25kD B binds BLyS, mature B survival

CD269 BCMA, TNFRSF13B 20kD mature B (membrane and perinuclear) APRIL & BAFF receptor, B survival & proliferation

CD270

TNFRSF14, tumor necrosis factor receptor superfamily, member 14 (herpes virus entry mediator), TR2, ATAR, HVEA, HVEM, LIGHTR

30kD lung, spleen, thymus receptor for BTLA, LIGHT and LT-α

CD271 NGFR, p75 (NTR) 45kDneurons (schwann cells, growing neurites), BM mesencymal cells

NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor, cell survival and death

CD272 BTLA 33kD Tact, B, remains on Th1 HVEM receptor, inhibitory response

CD273 B7DC, PD-L2, PDCD1L2 25kD DC subset, mono, macPD-1 receptor, costimulation or suppression of T proliferation

CD274 B7-H1, PD-L1 33kD leukocytes, broad PD-1 receptor, costimulation of lymphocytes

CD275 B7-H2, ICOSL, B7-RP1, GL50 60kD B, DC, mono costimulation, cytokine production

42

Human CD Antigens


CD276 B7-H3 40-45kD in vitro cultured DC and mono, Tact, mammary tissue costimulation, T activation

CD277 BT3.1, butyrophilin SF3 A1, BTF5 56kDT, B, NK, mono, DC, endoth, CD34+ cells, tumor cell lines, CD14+ cells

T activation

CD278 ICOS, AILIM 55-60kD Tact, Th2 binds ICOS-L, T costimulation

CD279 PD1, SLEB2 55kD Tact and BactB7-H1 & B7-DC receptor, autoimmune disease and peripheral tolerance

CD280 ENDO180, UPARAP 180kD chondrocytes, fibroblasts, endothelial, macmannose receptor, collagen matrix remodeling and endocytic recycling

CD281 TLR1 90kD low levels in PBMC, mono and possibly DC innate immunity, w/ TLR2

CD282 TLR2 90kD mono, neutrophil, up-regulated in macbinds dsRNA, response to bacterial lipoproteins, innate immunity

CD283 TLR3 100kD derived moDC (may be intracellular) binds dsRNA, innate immunity

CD284 TLR4 100kD PBMC (weak in mono, immature DC & neutro)binds LPS, innate immunity, associates with MD2 & CD14

CD289 TLR9 120kD pDC (intracellular) binds CpG-DNA, innate immunity

CD292 BMPR1A, ALK3 57kD bone progenitor BMP 2 & 4 receptor, bone development

CD293 BMPR1B, ALK6 57kD bone progenitor BMP receptor, bone development

CD294 CRTH2, GPR44 55-70kD Th2, eosinophils, basophilsbinds prostaglandin D2, stimulatory effects on Th2, allergic inflammation

CD295 LeptinR, LEPR 132kD broadadipose metabolism, immune dysfunction in obesity

CD296 ART1, RT6, ART2 37kD heart and skeletal muscle, peripheral T, NK subsetmodifies integrins during differentiation, ADP ribosylation of target proteins

CD297 ART4, dombrock blood group 38kD erythroid, monoact ADP ribosylation of target proteins

CD298 Na+/K+-ATPase b3 subunit 52kD broadtransport sodium & potassium ions across membrane

CD299DC-SIGN-related, LSIGN, DC-SIGN2

45kD endothelial subsetbinds ICAM3, HIV-1 gp120, coreceptor w/ DC-SIGN, HIV infection

CD300aCMRF35H, IRC1, IRp60 CLM-8, MAIR-1, LMIR-1

60kDNK, mono, neutrophils, T and B subset and lymphocytic cell lines, AML

unknown

CD300c CMRF35A, LIR 23kD mono, neutrophils, monocytic cell lines, B & T subsets unknown

CD300e CMRF35L 45kD mono, mac, DC unknown

CD300f IREM1, MAIR-V 60kD myeloid inhibitory receptor

43

Human CD Antigens


CD301MGL, HML2 DCASGPR, CLECSF13, CLECSF14, GalNAc

38kD immature DC binds Tn antigen, uptake of glycosylated antigens

CD303 BDCA2, HECL CLEC4C 38kD plasmacytoid dendritic cells inhibit IFN-α production

CD304 BDCA4, neuropilin 1 VEGF165R 130kDneurons, CD4+/CD25+ Treg, pDC, endothelial and tumor cells

interacts w/ VEGF165 & semaphorins, co-receptor with plexin, axonal guidance, angiogenesis, cell survival, migration

CD305 LAIR1 32-40kD NK, B, T, mono DCs, eosinophils, basophils mast cells inhibitory receptor on NK and T cells

CD307 IRTA2 FcRL5 CD307e BXMAS1 55-105kD B subset, B lymphomaB cell development, translocation in some lymphomas

CD309 VEGFR2, KDR 230kD endothelial, angiogenic precursor cells, hemangioblastbinds VEGF, regulates adhesion and cell signaling (ANNEXIN A5 and SHC1 binding also published)

CD302 DCL1, BIMLEC 19-28kD some myeloid and Hodgkin’s cell linesa fusion protein in Hodgkin’s lymphoma w/ DEC-205

CD306 LAIR2 16kD mono soluble, mucosal tolerance

CD307aFCRL1, Fc receptor-like 1, FCRH1, IFGP1, IRTA5, FCRL1

50kD mature B cellmay have role in B cell activation and differentiation

CD307bFCRL2, Fc receptor-like 2, FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C

55kD memory B cell may have role in B cell development

CD307cFCRL3, Fc receptor-like 3, FCRH3, IFGP3, IRTA3, SPAP2

89kD B cell, NK

CD307dFCRL4, Fc receptor-like 4, FCRH4, IGFP2, IRTA1

57kD memory B cell may inhibit B cell receptor

CD307eFCRL5, Fc receptor-like 5, CD307, FCRH5, IRTA2, BXMAS1, PRO820

106kD B cellmay have role in B cell development and differentiation

CD312 EMR2 90kD mono, mac, moDC, granslow cell adhesion and migration for phagocytosis

CD314 NKG2D, KLR 42kD NK, CD8+ activated, NK1.1+ T, some myeloid cellsbinds MHC class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine production, costimulation

CD315 CD9P1, SMAP6, FPRP, PTGFRN 135kD B subset, monoact w/ CD81 and CD9

CD316 EWI2, PGRL, CD81P3, KASP 63-75kD B, T cells, low on NK cells w/ CD81 & CD9, involved in cell migration

CD317 BST2, HM1.24 30-36kD B, T, NK, mono, DC, fibroblast cell line, myelomapre-B cell growth, overexpressed in multiple myeloma

CD318 CDCP1, SIMA135 135kD HSC (subset of CD34+), tumors cell adhesion with ECM

44

Human CD Antigens


CD319 CRACC, SLAMF7 66kD T, B and DC subset, NK, up-regulated in DC regulate T and NK cells

CD320 8D6A, 8D6 30kD follicular DC, germinal centers B proliferation, tumor formation

CD321 JAM1, F11 receptor 35kD platelet receptor, epithelia and endothelial, plateletstight junctions, involved in retrovirus entry into cells

CD322 JAM2, VE-JAM 43kD HEV, other endothcell adhesion, lymphocyte homing to secondary lymphoid organs

CD324 E-Cadherin, Uvomorulin 120kD non-neural epithcell adhesion, homotypic interaction & binds αE/β7

CD325 N-Cadherin, NCAD 140kD brain, skeletal and cardiac muscle cell adhesion, neuronal recognition

CD326Ep-CAM, Ly74 Tumor-associated calcium signal transducer 1 (TACSTD1)

35-40kD most epith cell membranes some tumors cell adhesion, metastatic carcinoma cell marker

CD327 SIGLEC6 49kD placenta, spleen, B . sialic-acid dependentadhesion, membrane- bound & secreted forms sialic-acid dependent

CD328 SIGLEC7, AIRM-1 75kDresting and activated NK, placenta, liver, spleen, lower in gran & mono

sialic-acid dependent adhesion, inhibit NK activation, hemopoiesis

CD329 SIGLEC9 50kD neutrophils and mono sialic-acid dependent adhesion molecule

CD331FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM

30kD fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors

CD332 FGFR2, BEK, KGFR115-135kD

fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors

CD333 FGFR3, ACH, CEK2 115kD fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors

CD334 FGFR4, JTK2, TKF 110kD fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors

CD335 NKp46, Ly-94 homolog 46kD NK activates NK cells upon non-MHC ligand binding

CD336 NKp44, Ly-95 homolog 44kD NK activates NK cells upon non-MHC ligand binding

CD337 NKp30, Ly117 30kD NK activates NK cells upon non-MHC ligand binding

CD338 ABCG2, BCRP, Bcrp1, MXR 73kD stem cell subset (side population) multi-drug resistance transporter

CD339 Jagged-1, JAG1, JAGL1, hJ1 135kD stromal cells, epithelial, AML binds Notch, hematopoiesis

CD340 HER2/neu, ERBB2, p185HER2 185kD BM, mesenchymal stem cellsmember of the ERBB family of receptor tyrosines, involved in a wide range of cellular responses

CD344 frizzled-4, Fz-4, hFz-4, FzE4 59kDadult kidney, lung, brain, liver, fetal neuronal intestinal cells

act of the Wntb-catenin pathway, regulation of tissue and cell polarity

45

Human CD Antigens


CD349 frizzled-9, Fz-9, hFz-9 65kDadult and fetal brain, testis, eye, skeletal muscle, and kindey, BM mesenchymal stem cells

act of the Wntb-catenin pathway, regulation of tissue and cell polarity

CD350 frizzled-10, Fz-10, hFz-10 65kD placenta and kidney, fetal lung and brainact of the Wntb-catenin pathway, regulation of tissue and cell polarity

CD351FCAMR, Fc receptor, IgA, IgM, high affinity, FCA/MR, FKSG87

57kD mesangial cell Fc receptor for IgA and IgM

CD352SLAMF6, SLAM family member 6, KALI, NTBA, KALIb, Ly108, NTB-A, SF2000

37kD NK, T, B triggers cytolyic activity of NK cells

CD353SLAMF8, SLAM family member 8, BLAME, SBBI42

32kD lymph node, spleen, thymus and bone marrowmay have role in B cell signalling and differentiation

CD354TREM1, triggering receptor expressed on myeloid cells 1, TREM-1

26kD liver, lung, spleen stimulates neutrophils and monos

CD355CRTAM, cytotoxic and regulatory T cell molecule

45kD MHC-I-restricted cells cytoxicity, tumor rejection

CD357TNFRSF18, tumor necrosis factor receptor superfamily, member 18, AITR, GITR, GITR-D

26kD lymph node, peripheral blood leukocytes, spleen receptor for TNSF18

CD358TNFRSF21, tumor necrosis factor receptor superfamily, member 21, DR6, BM-018

72kD fetal spinal cord, brian promotes apotosis, elevated in Alzheimer patients

CD360IL21R, interleukin 21 receptor, NILR

59kD thymus, spleen receptor for IL-21

CD361EVI2B, ecotropic viral integration site 2B, EVDB, D17S376

47kD bone marrow, PBMC, fibroblast

CD362SDC2, syndecan 2, HSPG, HSPG1, SYND2

22kDcell surface proteogylcan that bears heparan sulfate

CD363S1PR1, sphingosine-1-phosphate receptor 1, EDG1, S1P1, ECGF1, EDG-1, CHEDG1

42kD endotheial receptor for S1P, T cell migration

CD364PI16, peptidase inhibitor 16, dJ90K10.5, MGC45378, MSMBBP

49kD prostate, testis, ovary, intestine putative serine protease inhibitor

46

Human CD Antigens


CD365HAVCR1, TIM-1, HAVCR-1, TIMD1

38kD activated CD4 T cellrole in T-helper development, involved in hepititis A virus entry into cells

CD366 HAVCR2, TIM-3, TIMD3 33kD Th1 inhibitory receptor on Th1 cells

CD367CLEC4A, DCIR, DDB27, CLECSF6

27kD DC, myeloid cells, B-cell inhibitory receptor on DCs and B-cells

CD368CLEC4D, MCL, CLECSF8, CLEC-6, MPCL

24kD mono, macro endocytic receptor

CD369 CLEC7A, DECTIN-1, CLECSF12, 27kD peripheral blood leukocytes, DClectin, necessary for TLR2-mediated inflammatory response

CD370CLEC9A, HEEE9341, UNQ9341, DNGR1

27kD DC subset, mono subset endocytic receptor

CD371 CLEC12A, CLL-1, MICL, DCAL-2 30kD neutrophil, eosinophil, mono, DC signal transduction

47

Human CD Antigens


4-1BB Ligand CD137L Bact, DC, carcinoma cell lines T costimulation

Act1 CIKS 62kD B, Tnegative regulator of BAFFR and CD40 signaling, regulates IL-17RA signaling

AID Bact, Germinal Center BActivation-Induced Deaminase, Ig class switch recombination

AITR TNFRSF18, GITR Treg, Tact costimulation

AITRL TNFSF18, TL6, GITRL APC, endoth., peripheral mono

B7 family see CD273-276

B7-H4 B7-S1, B7x may interact with BTLA (?), inhibition

BAMBI TGFBR 29kD carcinoma cellpseudoreceptor for TGF-β (short cytoplasmic domain), growth inhibition

β-catenin 83kD broad, B, T development positively regulates Wnt-signaling

BCMA see CD269

BLIMP-1 90kD B, T B, Th1 differentiation

BLyS see CD257

BR3 see CD268

BTLA see CD272

CCR5 see CD195

CCR7 see CD197

c-Met HGFR/SFR 145kD epith, hematopoietic progenitors, early thymocytestumor growth/metastasis, Hepatocyte Growth Factor/Scatter Factor receptor, T development, hematopoiesis

CMKLR1 chemokine-like receptor 1 42kD pDC (CD123+), in vitro derived moDC binds chemerin, pDC recruitment, bone development

Cytokeratin 52-67kD epithelial intermediate filament protein, cytoskeletal formation

DcR3 TR6, TNFRSF6B 24kD tumorsFas decoy receptor, tumor evasion, secreted extracellularly

DEC-205 see CD205

DR3 TRAMP, Apo-3, WSL-1, LARD, TR3 45kD Tact, leukocytes, mono, granulocytes lymphocyte homeostasis, activates NF-κB

DR6 TR7 72kD lymph node, thymus death, Th2 response, interacts with TRADD

Eomes TBR2 70kD broad trophoblast development, CD8+ T & NK development

FcεRIa high-affinity IgE receptor mast cells, basophils triggers IgE-mediated allergic reactions

Foxp3 SCURFIN 50kD T subsets (CD4+/CD25+ subset and CD8+ subset) transcription factor, up-regulated in Tregs

48

Human Non-CD Antigens

49



GATA-3 GATA binding protein 3 48 kDavarious tissues, including CNS, inner ear, and mesodermal- and endodermal-derived tissues

TF that acts as a regulatorin the following: Th2 differentiation, sympathetic neuron development, and the maintenance of the differentiated state in epithelial cells

GILZ 14kD mast cells, mono, mac, DC, T transcriptional modulator, inhibits IL-2 production

gp130 see CD130

Granulysin 9, 15kD NK, Tact kills bacteria, induces apoptosis

Granzyme B Granzyme-2, CTLA-1 30kD cytotoxic T, NKtargets cell apoptotic lysis, cell-mediated immune responses

HLA-ABC11-12, 45kD

nucleated cells cell-mediated immune response & tumor surveillance

HLA-DR APC, Tact presentation of peptides to CD4+ T lymphocytes

HVEM TNFRSF14, TR2 60kD broad expressionreceptor for LIGHT, LT-α, BTLA, Herpes Simplex Virus, lymphocyte activation

ICOS see CD278

ICOSL see CD275

IGF-1R see CD221

IL-15Rα see CD215 monoactbinds to IL-15, w/ IL-2Rβ and common γ, IL-15 trans-presentation

ILT family see CD85

Integrin β1 see CD29



Integrin β5 100kD carcinoma cell lines, fibroblast lines w/ av subunit, vitronectin receptor

Integrin β7 130kD Leuk (maj)w/ CD49d or CD103, adhesion of leukocytes to endothelial cells

LAP 65-75kD non-covalently associates with TGFβ

MD-2 30KD w/ TLR4 distribution and LPS recognition

MICA/MICB 70kD intestinal epith, some tumors unregulated on epith after shock, NKG2D receptors

mTOR 289kD broad involved in cell metabolism, survival, protein synthesis

Nanog 34kD ES cells transcription factor, self renewal of ES cells

Nestin 220-240 neural stem cells

NKG2D see CD314

50

Human Non-CD AntigensAntigen Name Alternative Name MW Distribution Function

NOD2 CARD-15, IBD1 115kD monocytes, intracellular

Notch-1 Lin-12, Tan 1 290kD developing embryo, variety of adult tissues cell-cell interaction, cell fate determination

OPG osteoprotegerin, TNFRSF11B 46kD lymphnode, bone marrow bone resorption

OX-40 see CD134

OX-40 Ligand see CD252

Pax5 BSAP 50kD B B cell differentiation

PD-1 see CD279

PD-L1 see CD274

PD-L2 see CD273

Perforin 70-75kD CTL, NK cytolytic protein

Podoplanin 40kD lymphatic endothelial, follicular DC platelet aggregation, cancer metastasis

RP105 see CD180

RANK see CD181

RANKL see CD182

RORγ(t) see CD183 58kD colon, muscle, lymph node, and kidney TF that plays roles in mulltiple physiological processes

SAP SLAM-associated protein 14kD T, NK negatively regulates SLAM- family receptors

Siglec-7 AIRM1, QA79 see CD328

SLP-76 LCP2, pp76 76kD T, Blow T cell receptor mediated signaling

SSEA-1 stage-specific embryonic antigen-1 ES cells, embryonic carcinomas, germ cells down-regulated by differentiation



Stro-1 BM stroma, erythroid progenitors surface marker for immature mesenchymal cells

TACI see CD267

T-bet T-box protein 21 58kD Th1 cells transcription factor, T development/differentiation

TCL1 T cell leukemia/lymphomal 13kDB cell tumors, lymphoid lineages in a developmentally controlled manner, pDC

intracellular, lymphoid proto-oncogene

TCRαβ peripheral T subset antigen recognition

TCRγδ T subset antigen recognition

Tdtterminal deoxynucleotidyl transferase

60kD immature B, Ttemplate-independent addition of nucleotides at VDJ breakpoints

TLR1-TLR4 see CD281 - CD284

51



TLR5 TIL3 103kD mRNA: leukocytes, prostate, ovary, liver, lunginteracts w/ microbial lipoproteins, NF-κB, responds to Salmonella

TLR6 100kD mRNA: leukocytes, ovary, lunginteracts w/ microbial lipoproteins, protein sequence similar to hTLR1; regulates TLR2 response

TLR7 116kD mRNA: spleen, placenta, lung; up-regulated on mac innate immunity

TLR8 119kD mRNA: leukocytes, lung, neurons innate immunity

TLR9 see CD289 115kD lung, spleen innate immunity

TLR10 94kD mRNA: lymphoid tissues most closely related to TLR1 and TLR6

TNFRI see CD120a

TRA-1-60 Podocalyxin200-250kD

ES cells, embryonic carcinomas, germ cells, podocytes down-regulated by differentiation

TRA-1-81 Podocalyxin200-250kD

ES cells, embryonic carcinomas, germ cells, podocytes down-regulated by differentiation

TRAIL see CD253

TSLPR 50kD monocytes, DC, Bbinds TSLP (Thymic Stromal Lymphopoietin) to activate DC

TWEAK TNFSF12, APO3L activated monodeath, promotes IL-8 secretion, endothelial cell proliferation, and apoptosis

TWEAK Receptor see CD266

52

Mouse CD AntigensAntigen Name Alternative Name MW Distribution Function

CD1d CD1.1/1.2, Ly-38 43-49kD leukocytes, intestinal epith Ag presentation, mucosal immunity, w/ β2m, ligand for NKT cells

CD2 LFA-2, Ly-37, SRBC-R 45-58kD lymphocytes, pre-B, erythrocytes, myeloid, DC adhesion, T activation, CD48 receptor

CD3δ T3d 20kD T, thymocyte subset, NKT TCR subunit, TCR expression & signaling

CD3ε T3e 20kD T, thymocyte subset, NKT TCR subunit, TCR expression & signaling

CD3γ T3g 25kD T, thymocyte subset, NKT TCR subunit, TCR expression & signaling

CD4 Ly-4, L3T4 55kD thymocyte subset, T subset, DC TCR coreceptor, thymic differentiation, T activation, MHC class II receptor

CD5 Ly-1 67kD thymocytes, T, B subset (B1) T activation, T-B interaction, CD72 receptor

CD6 T12 100-130kD

thymocytes, T, neurons, not on B T differentiation & costimulation, CD166 receptor

CD7 40kD human early T marker, CD7KO has normal phenotype

CD8α Ly-2 32-34kD thymocyte subset, T subset, DC subset, not fresh NK TCR coreceptor, MHC class I receptor, T differentiation, homodimer or heterodimer w/ CD8β

CD8β Ly-3 30kD thymocyte subset, T subset, not fresh NK TCR coreceptor, MHC class I receptor, T differentiation, heterodimer w/ CD8α

CD9 p24 24-27kD myeloid, platelets, Tact, B subset, stromal cells, mesenchymal stem cells

cell adhesion, migration, T costimulation

CD10 CALLA, NEP, Mme 100kD fibroblasts, BM stromal cells non-lympoid tissuezinc-binding metalloproteinase, neutral endopeptidase ectoenzyme,

CD11a integrin aL, Ly-15, Itgal

80kD T, B, NK, gran, mono, mac, DC, thymocytes CD11a/CD18 (LFA-1) receptor for ICAM-1 and ICAM-2, adhesion, T costimulation

CD11b Mac-1, integrin αM, Itgam, CR3

170kD myeloid, NK, Tact, B subset CD11b/CD18 receptor for CD54 and CD102, adhesion to ECM, fibrinogen, & complement iC3b

CD11c p150, integrin αX, Itgax, CR4

150kD DC, myeloid, NK, T subset CD11c/CD18 receptor for fibrinogen & iC3b, adhesion

CD13 Aminopeptidase N, Lap1

150kD myeloid, endoth, DC zinc-binding metalloproteinase, antigen processing

CD14 LPS-R, Mo2 53-55kD mac, granlow receptor for LPS/LBP, LPS recognition

CD15 Lewis-X transient in brain fucosyl transferase (Fut4)

CD16 FcγRIII, Ly-17, Fcγr3 50-60kD NK, neutrophils, mast cells, mac Fcγ low affinity receptor, phagocytosis, ADCC, NK activation

CD18 Integrin β2, Itgb2 90-95kD leukocytes w/ CD11a, b and c, adhesion

CD19 B4 95kD B, FDC, good B lineage marker, not plasma cells w/ CD21 & CD81, BCR coreceptor, B activation/differentiation

53

Mouse CD Antigens


CD20 Ly-44, B1, Ms4a2 33-37kD B, T subset B differentiation/activation

CD21 CR2, CR1 150kD B, DC CD21/CD35 variant of CR2 gene, complement C3dR, w/ CD19 & CD81, BCR coreceptor

CD22 Lyb-8, Siglec-2 140-160kD

B adhesion, B-mono & B-T interactions, B activation, BM homing receptor for IgD+ B cells, CD75 counter-receptor

CD23 FcεRII, Ly-42, Fcεr1a 45-49kD B, mono, mac, gran, platelets, FDC, not B1 cells CD19/CD21/CD81 receptor, low affinity IgER, signaling

CD24a HSA, Ly-52, Nectadrin 35-52kD B, gran, mono, mac, Tact, erythrocytes, neurons several isoforms, B differentiation & adhesion, T costim, CD62P receptor

CD25 Ly-43, p55, IL2Rα 55kD pre-B, pre-T, Tact, Bact, DC subset, mono, mac low affinity IL-2 binding, w/ IL-2Rβ & γ forms IL-2 receptor high affinity, also soluble form

CD26 DPP4, THAM 110kD thymocyte subset, Tact, B, NK, epith dipeptidyl peptidase ectoenzyme, activation, adhesion

CD27 T14, Tnfrsf7 45kD medullary thymocytes, T, NK, B subset CD70 receptor, T costimulation

CD28 Tp44 45kD T, thymocytes, NK CD80 (B7-1) & B7-2 (CD86) receptor, T costimulation

CD29 Integrin β1, gpIIa, Itgb1

130kD leukocytes, fibroblasts, endoth, epith w/ CD49a-f (VLA-1-6), receptor for VCAM-1, MAdCAM-1 & ECM, VLAb, adhesion, embryonic development

CD30 Ki-1, Tnfrsf8 105-120kD

Tact CD153 receptor, lymphocyte proliferation, apoptosis, peripheral tolerance

CD31 PECAM-1, pgIIa 130-140kD

leukocytes, endothmultiple isoforms, CD38 receptor, signaling, platelet-endoth adhesion

CD32 FcγRII, Ly-17, Fcγr2b 40-60kD mono, mac, gran, B, Tact, not NK low affinity Fc receptor for aggregated Ig/immune complexes, ADCC

CD33 Siglec-3, gp67 67kD myeloid progenitors; gran possible role in hematopoiesis, binds sialic-acid

CD34 Mucosialin 90-120kD hematopoietic precursors, capillary endoth, BM stroma, mast cells CD62L receptor, adhesion

CD35 Cr1, Cr2 190kD B, granact, FDC CD21 & CD35 alternative splice variants of Cr2 gene, binds C3b & C4b, adhesion, phagocytosis

CD36 FAT, fatty acid translocase

88kD platelets, adipocytes, mono, mac, endoth, erythrocyte, B cells oxidized LDL receptor

CD37 mRNA: lymphoid, myeloid T-B interaction

CD38 Cd38-rs1, T10 42kD B, marginal zone B high, Tact, thymocyte subset, subsets in yolk sac, in fetal liver, in BM

Bact, CD31 receptor, ectoenzyme, ADP-ribosyl cyclase/hydrolase

CD39 Entpd1 70-100kD lymphocyteact, microglia, endoth, Treg subset ecto-nucleoside trisphosphate diphosphohydrolase

54


CD40 gp39 receptor, Tnfrsf5

45-50kD B, mono, mac, T subset, DC, endoth, thymic epith, induced on cardiac myocytes

CD154 receptor, T-B interaction, B costimulation, isotype-switching, & survival,

CD41 gpIIb, Itga2b, CD41b 110-125kD

platelets, megakaryocytes w/ CD61 forms GPIIb/IIIa, binds fibrinogen, fibronectin, vWF & thrombospondin

CD42 Gp9, GPIX 20kD platelets, megakaryocytes platelet activation, aggregation

CD43 Leukosialin, Ly-48, Spn, sialophorin

115 & 135kD

T, Tact, early B, B subset, plateletslow, not resting B, not DC isoforms, signaling, CD54R, B survival, adhesion

CD44H-CAM, Pgp-1, Hermes Ag

80-95kDhematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis

binds hyaluronic acid, adhesion

CD45 LCA, Ly-5, Ptprc 180-240kD

leukocytes, not mature erythrocytes tyrosine phosphatase, leukocyte differentiation/activation, pan-leukocyte marker

CD45.1 Ly5.1180-240kD

Ly-5.1 strains: SJL, DA, STS/A, RIII tyrosine phosphatase, signal transduction

CD45.2 Ly5.2 180-240kD

Ly-5.2 strains: BALB/c, C3H, C57BL/6, DBA/1, DBA/2, AKR, A, 129 tyrosine phosphatase, signal transduction

CD45R/CT1 cytotoxic Tact

CD45R B220 220kD B, NK progenitors, LAK, Tact, T cells with lpr/lpr mutant allele tyrosine phosphatase

CD45RA exon A isoform, tyrosine phosphatase

CD45RB 200-240kD

T subset, B, mono, mac, DC tyrosine phosphatase, signal transduction

CD45RC 200-240kD

T subset, B tyrosine phosphatase, signal transduction

CD45RO UCHL-1 180kD Tact, Bact, DC subset tyrosine phosphatase, signal transduction

CD46 MCP, membrane cofactor protein

41kD broad complement regulation, role in fertilization

CD47 IAP, Itgp, neurophilin 50kD hematopoietic cells, epith, endoth, fibroblasts, platelets w/ β3 integrins, adhesion, binds SIRP, thrombospondin receptor

CD48Blast-1, BCM-1, Sgp-60

45kD broad on lymphocytes, not fibroblasts adhesion, T costimulation, CD2 and Ly-9 receptor

CD49a VLA-1, Integrin α1, Itga1

180kD Tact, endoth adhesion, CD49a/CD29 binds collagen & laminin

CD49bVLA-2, Integrin α2, Itga2

165kD platelets, T subset, megakaryocytes, NK cells adhesion, CD49b/CD29 binds collagen & laminin

CD49cVLA-3, Integrin α3, Itga3

125kD B subset, Tlow CD49c/CD29 binds laminin, fibronectin, collagen

55

Mouse CD Antigens


CD49d VLA-4, Integrin α4, Itga4

150kD T, B, mono CD49d/CD29 binds fibronectin, VCAM-1, w/ b7 forms LPAM-1 & binds to MAdCAM-1, homing receptor

CD49e VLA-5, Integrin α5, Itga5

135kD thymocytes, Tact, splenic B cells adhesion, CD49e/CD29 binds fibronectin

CD49f VLA-6, Integrin α6, Itga6

120kD memory T, thymocytes, platelets adhesion, CD49f/CD29 binds laminin

CD50 Icam5, Ticn, Telencephalin

130kD brain, dopaminergic neurons adhesion

CD51 VitronectinR, Integrin αv, Itgav

125, 24kD platelets, megakaryocytes, endoth, osteoblasts, melanoma adhesion, CD51/CD61 binds vitronectin, von Willebrand factor, fibrinogen & thrombospondin

CD52 CAMPATH-1, MB7, CLS1

12kD mature lymphocytes, Treg subset

CD53 OX-44 35-42kD leukocytes, DC, osteoblasts, osteoclasts signaling

CD54 ICAM-1, Ly-47 85-110kD endoth, mono, resting lymph (high on activation) CD11a/CD18(LFA-1), CD11b/CD18(Mac-1) & CD43 receptor, adhesion, T costimulation

CD55 Decay Accelerating Factor

60-70kD broad, induced in uterus by estrogen similar to Crry, protection from autologous complement attack

CD56 NCAM 20-185kD neural tissue, multiple isoforms adhesion, neuron development, skeletal myogenesis

CD57 B3gat1, HNK-1 38kD GlucuronsyltransferaseP cell adhesion molecule; memory

CD58 (H) LFA-3 not defined in mouse

CD59 Protectin, MAC-inhibitor

19kD broad binds complement C8 & C9, blocks membrane attack complex assembly

CD60 (H) not defined in mouse

CD61 GPIIIa, Integrin β3, Itgb3

105kD platelets, megakaryocytes, mac, endoth CD41/CD61 or CD51/CD61 complexes adhere to ECM

CD62E E-selectin, ELAM-1, Sele 97

107-115kD

endoth sialyl-Lewis x receptor, leukocyte rolling & migration, tumor metastasis

CD62L L-selectin, LECAM-1, sell

74 & 95kD B, T, mono, gran, NK, thymocytes CD34, GlyCAM, & MAdCAM-1 receptor, lymphocyte homing, leukocyte tethering & rolling

CD62P P-selectin, Selp 140kD plateletsact, endoth CD162 & sialyl LewisX receptor, adhesion, neutrophil rolling, platelet-neutrophil, binds to CD24

CD63 MLA1 53kD plateletsact, mono, mac activated platelets marker, lysosomal membrane protein, translocates to surface upon activation, melanoma associated antigen

56


CD64 FcγRI 72kD mono, mac, DC, granact high affinity IgG receptor, phagocytosis, trypsin-sensitive, ADCC


CD66a Ceacam1, C-Cam 140-180kD

colon, liver, hematopoietic tissues cell-cell interaction, hepatitis virus receptor

CD68 Macrosialin, gp110 87-115kD predominantly intracellular, tissue mac, DClow lysosomal associated protein

CD69 Activation Inducer Molecule, VEA

35-39kD Tact, Bact, NKact, granact, thymocytes, platelets early activation marker, thymocyte development

CD70 Ki-24, Tnfsf7 50, 70, 90, 160kD

Bact, Tact, cardiac myocytes CD27 receptor, T & B costimulation

CD71 T9, Trfr 95kD proliferating cells, reticulocytes, erythroid precursors transferrin receptor, iron uptake, cell activation

CD72 Lyb-2 40-45kD B, FDC, T subset, polymorphic extracellular portion CD5 & CD100 receptor, B costimulation

CD73 Nt5e 69kD Treg, myeloid BM, CD4+ T cells ecto-5’-nucleotidase, T costimulation, adhesion

CD74 Ii, Ia-invariant chain 33-43kD B, mac, mono MHC class II traffic & function, antigen presentation

CD75 st6Gal I 44kD BM homing of recirculating B cells, CD22 counter-receptor putative role in tumor progression


CD79a Igα, mb-1, Ly-54 33 & 45kD B BCR subunit, BCR expression & signaling

CD79b Igβ, B29 37kD B BCR subunit, BCR expression & signaling

CD80 B7, B7-1, Ly-53 60kD Bact, Tact, mono, mac, DC, pancreatic β cells CD28 & CD152 receptor, costimulation, T-B interaction

CD81 TAPA-1 26kD T (double POS), B, NK, thymocytes, DC, endoth, fibroblast, melanomas, neuroblastomas, mac

w/ CD19 & CD21, signaling, T costimulation

CD82 KAI1, C33 50-53kD Tact, mRNA: spleen, kidney inhibits tumor cell mobility

CD83 H315 43kD DC, Tact, mRNA: spleen & brain regulation of T response, binds to a ligand on B cells

CD84 SLAMF5, GR6 70-85kD B, mac, mRNA: hematopoietic tissue homophilic adhesion

CD85K Gp49b, Lilrb4 37kD mast cells inflammation

CD86 B70, B7-2, Ly-58 80kD mono, Bact, Tact, DC CD28/CD152 receptor, T costimulation, T-B interaction

CD87 UPA-R, Plaur muPAR1 luminal epith of gastric mucosa PAR2 secreted uPA binding protein

CD88 C5aR, C5r1 40kD gran, neurons, astrocytes, microglia C5a receptor, neurodegeneration

CD89 FcαR, IgA receptor 55-75kD mono, mac, neutrophils, B subset, T subset phagocytosis, degranulation,

CD90 Thy-1 18kD thymocytes, T, hematopoietic subset, neuronshematopoietic stem cell & neuron differentiation, T activation

CD90.1 Thy-1.1 18kD thy1a (thy1.1) strains: AKR & RF & PL

57

Mouse CD Antigens


CD90.2 Thy-1.2 18kD thy1b (thy1.2) all other strains

CD91 lrp1, A2mr 600kD mono, mac, neurons, liver, fibroblasts receptor for a-2- macroglobulin, LDL, lipoprotein metabolism


CD93 AA4.1 antigen, C1qRp, early B lineage marker, Ly68

130-140kD

progenitor marker for early B cells, endo, megakaryoblasts, platelets

phagocytic complement C1q receptor

CD94 KP43, klrd1 43kD NK, T subset w/ NKG2, inhibits NK function

CD95 Apo-1, Fas 35kD thymocytes, lymphocytesact, fibroblast, mono, neutrophilCD95L(CD178) receptor, apoptosis induction, immune system regulation,

CD96 TACTILE, T cell Activation Increased Late Expression

160kD mRNA: spleen, mammary gland adhesion of activated T & NK

CD97 TM7LN1 TM7S lymphoid, myeloid CD55 receptor

CD98 4F2, Ly-10 80, 40kD thymocytes, lymphocytes, mono, BM cell activation, calcium flux

CD99 Pilr-1, D4 19kD endoth neutrophil migration

CD100Sema4d, semaphorinH

150kD mRNA: lymphoid & nervous tissues CD72 receptor, role in immune & nervous systems

CD101 IgSF3 131kD meyloid, DC, T subset, Treg subset role in susceptibility to type I diabetes

CD102 ICAM-2, Ly-60 55-65kD lymphocytes, mono, platelets, endoth binds CD11a/CD18 (LFA-1), costimulation

CD

Documents

Full Spectrum Cell AnalysisTM - LIANKE) BIO...CD125 CD126 FcεR1 IL-33R (ST-2) Pan Markers CD11b CD13 CD15 CD32 CD33 Surface Basophil Marker CD9 CD11a CD13 CD16 CD25 CD33 CD38 CD43