Ossein Microcrystalline Hydroxyapatite

(MCHA)

Produces more prolonged calcium balance than soluble calcium salts. Ossein MCHA provides both the inorganic constituents found in human bone AND the organic bone-growth factors that stimulate bone osteoblast cells.*

Vitamin D3 (1000 IU)

Converts to calcitriol, the active form of vitamin D3, in the kidneys. Calcitriol enhances calcium and phosphorous absorption and stimulates the synthesis of osteocalcin, an important structural protein in bone. Vitamin D3 is superior to vitamin D2, as it has been shown to raise blood levels 70% better than D2.*

PotassiumHelps neutralize acidic physiological pH, which can adversely affect bone health. In maintaining the acid–alkaline balance in our bodies, potassium helps avoid unhealthy levels of calcium excretion in the urine.*

MK-7 (Menaquinone-7)

The more bioavailable form of vitamin K2. MK-7 remains in circulation much longer than vitamin K1 and is responsible for the carboxylation of specific bone proteins needed for building bone. MK-7 also discourages unwanted calcium deposition in arteries.*

Boron A trace mineral important in calcium and bone metabolism. Supplemental boron has been shown to reduce excretion of calcium, magnesium and phosphorus*

Manganese, Copper, and Zinc Essential components of several enzymes involved in the formation of bone

How Do the Active Ingredients Function in this Product?

Bone-Up®

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

For more information visit www.jarrow.com

Promotes Bone Density*

Bone-Up® is the most advanced and complete nutritional regimen for maintaining strong, healthy bones.*

Bone-Up® utilizes the finest source of calcium available: Australian bovine bone ossein microcrystalline hydroxyapatite from chemical-free, range-grazed calves less than two years old (bones from veal calves are never used).

Other IngredientsMagnesium stearate (vegetable source) and silicon dioxide. Capsule consists of gelatin.

Mineral amounts are elemental.

Contains: Soy (in trace amounts).

No wheat, no gluten, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Suggested UsageTake 3 capsules twice per day with meals, preferably dividing the number of capsules equally with each meal (for a total of 6) to facilitate maximum absorption or as directed by your qualified health care consultant.

Health ClaimIn conjunction with regular, weight-bearing exercise and a healthy diet, calcium helps teen and young adult women build bone mass and maintain bone health, and may reduce their risk of osteoporosis later in life.* Daily calcium intake above 2,000 mg is not likely to provide additional benefit. Adequate calcium intake is also linked to reduced osteoporosis by slowing bone loss in older men and women.*

ORDERING INFORMATIONORDER CODE: BU120 BOTTLE SIZE: 120 CAPSULESORDER CODE: BU240 BOTTLE SIZE: 240 CAPSULESORDER CODE: BU360 BOTTLE SIZE: 360 CAPSULES

BoneP R O D U C T C A T E G O R Y

Who Can Benefit from this Product?Many Americans are not meeting the current recommendations for adequate calcium intake via diet or with supplement use. This product provides needed calcium, but also includes other essentials for proper calcium utilization by the body.

What Distinguishes this Product?• Complete Multinutrient Bone-health System• Published clinical trial with Bone-Up® • Ossein microcrystalline hydroxyapatite contains active bone-growth factors• #1 Imitated Bone Supplement• Bone-Up is always UP-FORMULATED™ to include the latest breakthroughs in bone health.

h e a l t h y l i v i n g t h r o u g h s c i e n c e & e d u c a t i o nQUICKReference Guide Jarrow

F O R M U L A S®

0111BU

Supplement FactsServing Size 6 Capsules

Amount Per 6 Capsules % DV

Vitamin C (as calcium ascorbate) 200 mg 333%Vitamin D3 (cholecalciferol) 1000 IU 250%MK-7 (vitamin K2 as menaquinone-7) 45 mcg 56% Calcium (elemental) 1000 mg 100%(from microcrystalline hydroxyapatite) Magnesium (as magnesium oxide) 500 mg 125%Zinc (as zinc monomethionate) 10 mg 67%Copper (as copper gluconate) 1 mg 50%Manganese (as manganese citrate) 1 mg 50%Potassium (as potassium citrate) 99 mg 3%Boron (as boron citrate) 3 mg ** Daily Value not established.

VITAMIN K2

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

For more information visit www.jarrow.com

Bone-Up®

Jarrow Formulas® Bone-Up® is an most advanced and complete nutritional regimen for maintaining strong, healthy bones.* Bone-Up has been a featured product of Jarrow Formulas for some time and has been updated through the years to reflect the latest scientific findings regarding skeletal health.

Bone Mass and HydroxyapatiteIn 1982, an important calcium supplementation study was concluded and reported by the Dept. of Medicine and Radiology, Royal Free Hospital in London, England. Fifty-three post-menopausal women diagnosed to have seriously impaired calcium absorption and accelerated bone loss were separated into three groups and studied for over 14 months. At the conclusion of the study, only the women that received 1,000 mg of calcium from hydroxyapatite along with vitamin D showed a significant increase in bone thickness.*

Hydroxyapatite produces more prolonged calcium balance than soluble calcium salts. It also allows the bone osteoblast cells to be more receptive to its components and to build bone tissue. Furthermore, hydroxyapatite provides both the organic and inorganic constituents found in human bone: hydroxyapatite microcrystals consist of calcium, phosphorous, oxygen, and hydrogen; the trace minerals zinc, strontium, silicon and iron; and proteins, amino acids and aminoglycans.*

Bone HealthBone consists of calcium and phosphorous crystals embedded in a framework of interlocking protein fibers. The protein fibers are made primarily of collagen. The mineral crystals give bone hardness, strength, and rigidity. Collagen fibers impart their quality of flexibility. Hydroxyapatite composes 67% of the weight of bone, and the collagenous fibers make up the remaining 33%.*

The average adult has 1,000 -1,200 grams of calcium in the body. Bones are the body’s largest calcium storehouse and will release calcium into the bloodstream in order to ensure correct blood levels of calcium. Thus, blood calcium levels can be normal while bone loss can be considerable.

Between 2 - 4% of a person’s skeleton is remodeled every year. This means that calcium and other minerals leave the bone in a process called resorption and then must be “remodeled” or replaced. Whether due to poor nutrition or reduced hormone levels with the onset of aging, the loss of calcium and other minerals from the bone creates tiny holes that make bones weak and brittle, particularly if collagen is being lost.

It has been estimated that post-menopausal women lose 0.7% to 2% of their bone per year while men lose 0.5%-0.7%. Between 45 and 75 years of age, women lose 30% of their skeletal structure and men lose 15%.

Calcium PlusIt starts with the finest source of calcium available: Australian bovine bone hydroxyapatite from chemical-free, range-grazed calves less than two years old (bones from veal calves are never used). Skeletal health, however, requires more than calcium. Scientific evidence conclusively demonstrates the need for other nutrients like vitamin D3, vitamin K, potassium, magnesium, boron, and trace minerals such as zinc, copper, and manganese.*

Who Needs to Supplement Calcium?Research has indicated that 85% of women over the age of 20 and at least 50% of men from age 35 consume less than the RDI for calcium. Caffeine, alcohol, sugar, chocolate, high protein diets and soda pops – particularly colas that are high in phosphorous can deplete calcium.

In addition, calcium absorption has long been thought to be stomach-acid dependent, but both stomach acid production and calcium absorption decline with age!

Bone-Up Clinical TrialThe results of a recent clinical trial published in the Journal of Nutritional & Environmental Medicine (Disilvestro RA et al. J Nutr Environ Med. 2007; 16(1):26-32) found that exercise and supplementation of calcium, vitamin D3 and other micronutrients from Bone-Up significantly improved bone health in young adult women.*

In an 8-week double-blind placebo-controlled study of 24 female students ages 18 to 24, supplementation with Bone-Up (not placebo) was found to produce statistically significant decreases in markers of bone degradation, while increasing levels of plasma bone specific alkaline phosphatase (an indicator of bone synthesis), plasma 2,5-OH-vitamin D (an indicator of vitamin D nutritional status) and plasma parathyroid hormone.*

ReferencesAvailable upon request

h e a l t h y l i v i n g t h r o u g h s c i e n c e & e d u c a t i o nQUICKReference Guide Jarrow

F O R M U L A S®