fields.scripps.edufields.scripps.edu/published/foxo1_Tabas_… · XLS file · Web view · 2012-01-05Tax_Id=10090 Gene_Symbol=Glul 12 kDa protein FOXO_KO.36700.36700.3 K.CVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFR.D

DTASelect v2.0.49/ip2_data/catclw/Ira/FOXO_KO_2011_05_17_21_4647/search/projects2012_01_04_16_21071/data/2/rpark/ip2_data/taoxu/database//EBI-IPI_mouse_3.71_03-24-2010_reversed.fastaProLuCID 1.3.1 in SQT format. -p 1 -y 0 --trypstat --fp 0.005 --extra --pI -DM 10 --DB --dm -in -m 1 --quiet

1 Use criteria0 Minimum peptide probability

0.005 Peptide global false discovery rate0 Minimum protein probability1 Protein false discovery rate1 Minimum charge state

50 Maximum charge state-1 Minimum ion proportion

10000 Maximum Sp rank-1 Minimum Sp score10 Maximum mass deviation (ppm)

1 Define delta mass with respect to nearest isotopeInclude Modified peptide inclusionAny Tryptic status requirement

0 Multiple, ambiguous IDs allowedIgnore Peptide validation handlingXCorr Purge duplicate peptides by protein

0 Include only loci with unique peptide0 Remove subset proteins

Ignore Locus validation handling0 Minimum modified peptides per locus1 Minimum peptides per locus

Locus Sequence Spectrum Sequence Length MolWt pI Validation Descriptive NameUnique FileName XCorr DeltCN Conf% M+H+ CalcM+H+ PPM TotalIntensIPI:IPI00 11 13 79.10% 115 11651 4.5 U Tax_Id=10090 Gene_Symbol=Rplp2 60S acidic ribosomal protein P2 * FOXO_KO.1 4.4662 0.4118 100 1545.773 1545.775 -1.5 281313.5* FOXO_KO.1 5.4332 0.5553 100 1901.003 1900.997 3 145244.6* FOXO_KO.1 4.0017 0.4055 100 1901.997 1900.997 -1.8 256635.3* FOXO_KO.1 4.2124 0.573 100 1417.682 1417.681 0.7 571260.7* FOXO_KO.1 5.5592 0.3878 100 1773.904 1772.903 -1.2 332110.5* FOXO_KO.3 5.2252 0.3429 99.9 3839.035 3837.024 1.1 16986.2

FOXO_KO.2 3.42 0.4502 100 1242.67 1242.669 1 37465FOXO_KO.2 4.315 0.4502 100 1242.668 1242.669 -0.8 232096.5FOXO_KO.1 3.4748 0.2429 99.5 3275.69 3274.691 -1.4 43193.1FOXO_KO.2 5.541 0.4457 100 1951.763 1949.759 -1.3 150481.6FOXO_KO.3 4.3836 0.4594 100 2109.691 2109.692 -0.2 90987.6

IPI:IPI00 7 27 70.10% 77 8594 4.5 U Tax_Id=10090 Gene_Symbol=Actb Beta-actin (Fragment) FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1

FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2

IPI:IPI00 99 187 61.80% 652 69518 6.9 U Tax_Id=10090 Gene_Symbol=Foxo1 forkhead box O1 FOXO_KO.3 6.5565 0.5555 100 2362.096 2361.092 0.5 1703343FOXO_KO.1 3.849 0.4227 100 1342.689 1342.69 -0.8 578617.4FOXO_KO.2 5.7754 0.4884 100 1722.9 1721.897 -0.5 175220FOXO_KO.2 4.379 0.4616 100 1803.87 1801.863 -0.1 235785.1FOXO_KO.2 4.2667 0.4576 100 1565.796 1565.796 0.4 141601.3FOXO_KO.3 4.127 0.3501 100 1646.767 1645.762 0.6 274076.3FOXO_KO.3 5.5713 0.4686 100 2382.202 2381.198 0.2 95608.7FOXO_KO.3 5.8 0.5151 100 2483.302 2482.301 -1 44661.6FOXO_KO.3 4.1355 0.3852 100 1666.9 1666.898 0.9 190782FOXO_KO.3 3.7576 0.3609 99.9 1667.905 1666.898 2 138576.9FOXO_KO.3 4.3859 0.3872 100 1747.878 1746.865 5.9 195357.6FOXO_KO.3 4.291 0.4014 100 1747.869 1746.865 0.4 160672.7FOXO_KO.4 5.0641 0.3484 100 1747.871 1746.865 1.6 208054.4FOXO_KO.4 4.2394 0.4021 100 1510.799 1510.797 1.1 196705FOXO_KO.3 3.8895 0.2746 99.9 1591.769 1590.764 1.1 222276.8FOXO_KO.4 3.9542 0.2775 99.9 1591.765 1590.764 -1 259262.1FOXO_KO.1 6.0437 0.5087 100 1974.943 1972.94 -1.7 195926.8FOXO_KO.1 3.0161 0.3618 100 1251.558 1251.56 -1.6 87628.9FOXO_KO.1 3.8266 0.3195 100 1251.558 1251.56 -1.6 2042793FOXO_KO_w 5.1297 0.3394 100 1721.82 1721.82 -0.4 34864.6FOXO_KO_w 4.1223 0.2673 99.9 1801.79 1801.786 2.2 17309.1FOXO_KO.2 5.7697 0.4974 100 2205.038 2205.039 -0.8 51281.9FOXO_KO.2 2.4459 0.393 100 1391.639 1391.641 -1.5 36196.2FOXO_KO.2 3.033 0.4257 100 1391.644 1391.641 2 218721.7FOXO_KO.3 2.6589 0.2916 99.8 1471.605 1471.608 -1.6 376224.7FOXO_KO.2 3.8107 0.4194 100 2083.944 2083.942 0.9 73697.9FOXO_KO.2 3.0147 0.3241 99.9 2083.943 2083.942 0.7 145956.2FOXO_KO.5 4.6972 0.4355 100 2221.085 2220.089 -3.6 103143.5FOXO_KO.8 4.0073 0.4426 100 2300.049 2300.055 -2.8 275023.3FOXO_KO.8 3.7162 0.29 99.9 2300.041 2300.055 -6.4 205800.1FOXO_KO.8 6.577 0.6241 100 2091.985 2091.994 -4.3 131898FOXO_KO.9 5.8093 0.5799 100 2172.961 2171.96 -1.3 441850.4FOXO_KO.9 6.7078 0.5282 100 2172.958 2171.96 -2.8 98574.9FOXO_KO.9 5.4663 0.4337 100 2171.956 2171.96 -2 322260.9FOXO_KO.1 4.7626 0.5515 100 2043.866 2043.866 0.2 167846.8FOXO_KO.1 4.8313 0.5319 100 2043.867 2043.866 0.5 208505.4FOXO_KO.2 3.8862 0.4287 100 2403.951 2402.946 0.6 43568.1FOXO_KO.3 4.1711 0.3731 100 2483.918 2482.913 0.7 24133.9FOXO_KO.3 3.3017 0.4941 100 2482.909 2482.913 -1.5 24730.8FOXO_KO.3 4.066 0.3432 99.9 2484.921 2482.913 0.5 177486.2FOXO_KO.2 4.8072 0.4009 100 2578.143 2576.134 1.1 54457.8FOXO_KO.2 5.4772 0.4175 100 2578.115 2576.134 -9.8 1321646FOXO_KO.2 3.053 0.279 99.8 2657.104 2656.1 0 313119.5FOXO_KO.2 4.323 0.1953 99.5 2658.084 2656.1 -8.8 289242.5FOXO_KO.2 4.6664 0.2695 99.9 2658.11 2656.1 1.3 111442

FOXO_KO.2 4.0108 0.3331 99.9 2737.072 2736.066 0.8 121289.9FOXO_KO.2 3.3197 0.2376 99.5 2737.072 2736.066 0.6 1293430FOXO_KO.1 2.9188 0.4095 100 1160.494 1160.494 -0.1 574524.2FOXO_KO.2 5.8277 0.5164 100 2984.297 2983.299 -1.7 161593.2FOXO_KO.2 6.1944 0.5584 100 3185.418 3183.415 -1.2 354553.1FOXO_KO.2 3.9095 0.36 99.9 3998.852 3996.853 -2 26434.9FOXO_KO.3 3.5445 0.3645 99.9 3998.852 3996.853 -2 17163.5FOXO_KO.3 3.8372 0.259 99.7 3997.851 3996.853 -1.4 19759FOXO_KO.3 3.7558 0.372 99.9 3998.867 3996.853 1.9 16667.9FOXO_KO.3 4.2529 0.3343 99.9 3998.865 3996.853 1.3 19858.2FOXO_KO.3 4.1274 0.3322 99.9 3997.857 3996.853 0.2 11663.6FOXO_KO.4 4.7431 0.3935 100 3998.854 3996.853 -1.6 14767.9FOXO_KO.6 3.9276 0.2202 99.5 3998.858 3996.853 -0.5 12719.8FOXO_KO.3 5.6043 0.3501 100 3998.859 3996.853 -0.2 52306.2FOXO_KO.2 3.3521 0.3399 99.9 4078.82 4076.82 -1.6 9111.1FOXO_KO.2 5.9937 0.4897 100 3607.698 3607.699 -0.2 165184.9FOXO_KO.1 2.689 0.4303 100 1433.647 1433.646 0.4 45262.4FOXO_KO.2 6.6874 0.5329 100 2042.945 2041.938 1.8 262701.6FOXO_KO.2 5.581 0.4982 100 2856.379 2855.377 -0.2 21431.6FOXO_KO.2 5.3399 0.4978 100 2856.377 2855.377 -1 63427.8FOXO_KO.2 4.1225 0.4004 100 2936.35 2935.343 1.4 53563.1FOXO_KO.2 4.1415 0.3363 99.9 2936.34 2935.343 -2.1 127282FOXO_KO.2 5.5569 0.479 100 2619.2 2618.194 1.1 102045.4FOXO_KO.2 5.0109 0.2939 99.9 2619.2 2618.194 1.2 135994.5FOXO_KO.2 3.6783 0.2715 99.9 2700.149 2698.16 -6.6 17271.6FOXO_KO.2 2.7741 0.3529 99.9 2700.15 2698.16 -6.1 12420.1FOXO_KO.1 5.2747 0.5129 100 1842.896 1841.885 4.3 106481.7FOXO_KO.2 4.0932 0.36 100 2874.378 2873.373 0.4 28020.6FOXO_KO.2 4.8751 0.3452 99.9 2875.359 2873.373 -7.3 459831.7FOXO_KO.2 3.0152 0.2385 99.6 2955.344 2953.34 -0.8 23277.7FOXO_KO.2 2.6601 0.3527 99.8 2955.328 2953.34 -6.2 18379.2FOXO_KO.2 3.9205 0.2896 99.9 2954.324 2953.34 -6.3 114236.1FOXO_KO.2 4.8122 0.4173 100 2955.327 2953.34 -6.4 777958FOXO_KO.2 4.7445 0.4677 100 2955.327 2953.34 -6.4 62565.4FOXO_KO.2 2.8398 0.3165 99.8 3034.306 3033.306 -1.2 17195.8FOXO_KO.2 3.6909 0.3515 99.9 3034.285 3033.306 -8 71776.3FOXO_KO.2 5.718 0.5425 100 2619.235 2617.232 -1.5 74218FOXO_KO.2 4.3017 0.4467 100 2617.23 2617.232 -0.7 268161.6FOXO_KO.2 4.3834 0.2386 99.8 2699.198 2697.198 -2.8 116120.1FOXO_KO.2 5.1777 0.3849 100 2698.203 2697.198 0.5 215370.4FOXO_KO.1 3.0206 0.3557 99.9 1905.943 1905.942 0.3 110888.9FOXO_KO.1 3.805 0.2775 99.9 2525.258 2524.256 -0.7 29515FOXO_KO.1 3.2193 0.2744 99.6 2526.263 2524.256 -0.1 132975.7FOXO_KO.2 4.2477 0.3644 99.9 3831.817 3829.811 -0.3 15469.1FOXO_KO.2 4.3674 0.4493 100 3213.503 3211.497 -0.3 116569FOXO_KO.2 6.1473 0.4376 100 2316.156 2315.152 0 75407.8FOXO_KO.2 3.7186 0.3353 100 2396.121 2395.118 -0.2 81893.4FOXO_KO.2 3.9302 0.254 99.8 2396.12 2395.118 -0.6 210596.5

FOXO_KO.4 4.4419 0.1962 99.5 3547.727 3547.705 6.2 130835.8FOXO_KO.4 4.1322 0.2764 99.9 3548.712 3547.705 1 201631.6FOXO_KO.2 4.3135 0.2624 100 1394.689 1392.683 -0.3 357333.7FOXO_KO.1 3.5519 0.2249 99.9 1251.566 1251.571 -4.1 4.79E+07FOXO_KO.2 3.1934 0.264 99.9 1331.537 1331.537 0.2 159418.1

* FOXO_KO.3 3.4481 0.2758 99.7 4313.935 4311.963 -8 18217.8IPI:IPI00 105 295 61.80% 652 69502 6.9 U Tax_Id=10090 Gene_Symbol=Foxo1 Forkhead box protein O1

FOXO_KO.3 6.5565 0.5555 100 2362.096 2361.092 0.5 1703343FOXO_KO.1 3.849 0.4227 100 1342.689 1342.69 -0.8 578617.4FOXO_KO.2 5.7754 0.4884 100 1722.9 1721.897 -0.5 175220FOXO_KO.2 4.379 0.4616 100 1803.87 1801.863 -0.1 235785.1FOXO_KO.2 4.2667 0.4576 100 1565.796 1565.796 0.4 141601.3FOXO_KO.3 4.127 0.3501 100 1646.767 1645.762 0.6 274076.3FOXO_KO.3 5.5713 0.4686 100 2382.202 2381.198 0.2 95608.7FOXO_KO.3 5.8 0.5151 100 2483.302 2482.301 -1 44661.6FOXO_KO.3 4.1355 0.3852 100 1666.9 1666.898 0.9 190782FOXO_KO.3 3.7576 0.3609 99.9 1667.905 1666.898 2 138576.9FOXO_KO.3 4.3859 0.3872 100 1747.878 1746.865 5.9 195357.6FOXO_KO.3 4.291 0.4014 100 1747.869 1746.865 0.4 160672.7FOXO_KO.4 5.0641 0.3484 100 1747.871 1746.865 1.6 208054.4FOXO_KO.4 4.2394 0.4021 100 1510.799 1510.797 1.1 196705FOXO_KO.3 3.8895 0.2746 99.9 1591.769 1590.764 1.1 222276.8FOXO_KO.4 3.9542 0.2775 99.9 1591.765 1590.764 -1 259262.1FOXO_KO.1 6.0437 0.5087 100 1974.943 1972.94 -1.7 195926.8FOXO_KO.1 3.0161 0.3618 100 1251.558 1251.56 -1.6 87628.9FOXO_KO.1 3.8266 0.3195 100 1251.558 1251.56 -1.6 2042793FOXO_KO_w 5.1297 0.3394 100 1721.82 1721.82 -0.4 34864.6FOXO_KO_w 4.1223 0.2673 99.9 1801.79 1801.786 2.2 17309.1FOXO_KO.2 5.7697 0.4974 100 2205.038 2205.039 -0.8 51281.9FOXO_KO.2 2.4459 0.393 100 1391.639 1391.641 -1.5 36196.2FOXO_KO.2 3.033 0.4257 100 1391.644 1391.641 2 218721.7FOXO_KO.3 2.6589 0.2916 99.8 1471.605 1471.608 -1.6 376224.7FOXO_KO.2 3.8107 0.4194 100 2083.944 2083.942 0.9 73697.9FOXO_KO.2 3.0147 0.3241 99.9 2083.943 2083.942 0.7 145956.2FOXO_KO.5 4.6972 0.4355 100 2221.085 2220.089 -3.6 103143.5FOXO_KO.8 4.0073 0.4426 100 2300.049 2300.055 -2.8 275023.3FOXO_KO.8 3.7162 0.29 99.9 2300.041 2300.055 -6.4 205800.1FOXO_KO.8 6.577 0.6241 100 2091.985 2091.994 -4.3 131898FOXO_KO.9 5.8093 0.5799 100 2172.961 2171.96 -1.3 441850.4FOXO_KO.9 6.7078 0.5282 100 2172.958 2171.96 -2.8 98574.9FOXO_KO.9 5.4663 0.4337 100 2171.956 2171.96 -2 322260.9FOXO_KO.1 4.7626 0.5515 100 2043.866 2043.866 0.2 167846.8FOXO_KO.1 4.8313 0.5319 100 2043.867 2043.866 0.5 208505.4FOXO_KO.2 3.8862 0.4287 100 2403.951 2402.946 0.6 43568.1FOXO_KO.3 4.1711 0.3731 100 2483.918 2482.913 0.7 24133.9FOXO_KO.3 3.3017 0.4941 100 2482.909 2482.913 -1.5 24730.8FOXO_KO.3 4.066 0.3432 99.9 2484.921 2482.913 0.5 177486.2FOXO_KO.2 4.8072 0.4009 100 2578.143 2576.134 1.1 54457.8

FOXO_KO.2 5.4772 0.4175 100 2578.115 2576.134 -9.8 1321646FOXO_KO.2 3.053 0.279 99.8 2657.104 2656.1 0 313119.5FOXO_KO.2 4.323 0.1953 99.5 2658.084 2656.1 -8.8 289242.5FOXO_KO.2 4.6664 0.2695 99.9 2658.11 2656.1 1.3 111442FOXO_KO.2 4.0108 0.3331 99.9 2737.072 2736.066 0.8 121289.9FOXO_KO.2 3.3197 0.2376 99.5 2737.072 2736.066 0.6 1293430FOXO_KO.1 2.9188 0.4095 100 1160.494 1160.494 -0.1 574524.2FOXO_KO.2 5.8277 0.5164 100 2984.297 2983.299 -1.7 161593.2FOXO_KO.2 6.1944 0.5584 100 3185.418 3183.415 -1.2 354553.1FOXO_KO.2 3.9095 0.36 99.9 3998.852 3996.853 -2 26434.9FOXO_KO.3 3.5445 0.3645 99.9 3998.852 3996.853 -2 17163.5FOXO_KO.3 3.8372 0.259 99.7 3997.851 3996.853 -1.4 19759FOXO_KO.3 3.7558 0.372 99.9 3998.867 3996.853 1.9 16667.9FOXO_KO.3 4.2529 0.3343 99.9 3998.865 3996.853 1.3 19858.2FOXO_KO.3 4.1274 0.3322 99.9 3997.857 3996.853 0.2 11663.6FOXO_KO.4 4.7431 0.3935 100 3998.854 3996.853 -1.6 14767.9FOXO_KO.6 3.9276 0.2202 99.5 3998.858 3996.853 -0.5 12719.8FOXO_KO.3 5.6043 0.3501 100 3998.859 3996.853 -0.2 52306.2FOXO_KO.2 3.3521 0.3399 99.9 4078.82 4076.82 -1.6 9111.1FOXO_KO.2 5.9937 0.4897 100 3607.698 3607.699 -0.2 165184.9FOXO_KO.1 2.689 0.4303 100 1433.647 1433.646 0.4 45262.4FOXO_KO.2 6.6874 0.5329 100 2042.945 2041.938 1.8 262701.6FOXO_KO.2 5.581 0.4982 100 2856.379 2855.377 -0.2 21431.6FOXO_KO.2 5.3399 0.4978 100 2856.377 2855.377 -1 63427.8FOXO_KO.2 4.1225 0.4004 100 2936.35 2935.343 1.4 53563.1FOXO_KO.2 4.1415 0.3363 99.9 2936.34 2935.343 -2.1 127282FOXO_KO.2 5.5569 0.479 100 2619.2 2618.194 1.1 102045.4FOXO_KO.2 5.0109 0.2939 99.9 2619.2 2618.194 1.2 135994.5FOXO_KO.2 3.6783 0.2715 99.9 2700.149 2698.16 -6.6 17271.6FOXO_KO.2 2.7741 0.3529 99.9 2700.15 2698.16 -6.1 12420.1FOXO_KO.1 5.2747 0.5129 100 1842.896 1841.885 4.3 106481.7FOXO_KO.2 4.0932 0.36 100 2874.378 2873.373 0.4 28020.6FOXO_KO.2 4.8751 0.3452 99.9 2875.359 2873.373 -7.3 459831.7FOXO_KO.2 3.0152 0.2385 99.6 2955.344 2953.34 -0.8 23277.7FOXO_KO.2 2.6601 0.3527 99.8 2955.328 2953.34 -6.2 18379.2FOXO_KO.2 3.9205 0.2896 99.9 2954.324 2953.34 -6.3 114236.1FOXO_KO.2 4.8122 0.4173 100 2955.327 2953.34 -6.4 777958FOXO_KO.2 4.7445 0.4677 100 2955.327 2953.34 -6.4 62565.4FOXO_KO.2 2.8398 0.3165 99.8 3034.306 3033.306 -1.2 17195.8FOXO_KO.2 3.6909 0.3515 99.9 3034.285 3033.306 -8 71776.3FOXO_KO.2 5.718 0.5425 100 2619.235 2617.232 -1.5 74218FOXO_KO.2 4.3017 0.4467 100 2617.23 2617.232 -0.7 268161.6FOXO_KO.2 4.3834 0.2386 99.8 2699.198 2697.198 -2.8 116120.1FOXO_KO.2 5.1777 0.3849 100 2698.203 2697.198 0.5 215370.4FOXO_KO.1 3.0206 0.3557 99.9 1905.943 1905.942 0.3 110888.9FOXO_KO.1 3.805 0.2775 99.9 2525.258 2524.256 -0.7 29515FOXO_KO.1 3.2193 0.2744 99.6 2526.263 2524.256 -0.1 132975.7FOXO_KO.2 4.2477 0.3644 99.9 3831.817 3829.811 -0.3 15469.1

FOXO_KO.2 4.3674 0.4493 100 3213.503 3211.497 -0.3 116569FOXO_KO.2 6.1473 0.4376 100 2316.156 2315.152 0 75407.8FOXO_KO.2 3.7186 0.3353 100 2396.121 2395.118 -0.2 81893.4FOXO_KO.2 3.9302 0.254 99.8 2396.12 2395.118 -0.6 210596.5FOXO_KO.4 4.4419 0.1962 99.5 3547.727 3547.705 6.2 130835.8FOXO_KO.4 4.1322 0.2764 99.9 3548.712 3547.705 1 201631.6FOXO_KO.2 4.3135 0.2624 100 1394.689 1392.683 -0.3 357333.7

* FOXO_KO.5 4.02 0.2603 99.8 5669.605 5669.597 1.4 218680FOXO_KO.1 3.5519 0.2249 99.9 1251.566 1251.571 -4.1 4.79E+07FOXO_KO.2 3.1934 0.264 99.9 1331.537 1331.537 0.2 159418.1

* FOXO_KO.3 4.7675 0.3636 100 3065.384 3063.379 -0.7 67282.7* FOXO_KO.3 6.0652 0.3734 100 3064.387 3063.379 1.5 1.40E+07* FOXO_KO.3 5.2437 0.3499 99.9 3064.38 3063.379 -0.6 2320132* FOXO_KO.3 3.2533 0.2085 99.5 3144.354 3143.345 1.8 16383.9* FOXO_KO.3 5.5807 0.3284 99.9 3144.348 3143.345 -0.2 92864.3* FOXO_KO.3 7.3849 0.4522 100 2835.314 2834.309 0.5 565784.2IPI:IPI00 22 50 61.00% 246 28212 4.9 U Tax_Id=10090 Gene_Symbol=Ywhah 14-3-3 protein eta

FOXO_KO.1 5.1642 0.4823 100 1828.82 1828.82 -0.1 134824.6FOXO_KO.1 4.2392 0.4499 100 1829.823 1828.82 -0.6 347394.8

* FOXO_KO.1 4.6274 0.4083 100 1587.771 1586.766 1.3 777115* FOXO_KO.1 3.4469 0.1916 99.5 1586.764 1586.766 -0.8 134668.8* FOXO_KO.2 5.2739 0.4673 100 2476.274 2475.273 -0.9 54864.3* FOXO_KO.2 2.9886 0.3871 99.9 2475.267 2475.273 -2.4 113327.6* FOXO_KO.4 4.0747 0.3498 99.9 2359.244 2359.242 0.6 104803.1* FOXO_KO.4 6.1008 0.3877 100 2104.095 2102.105 -8.1 119232.1* FOXO_KO.4 4.9335 0.4349 100 2103.11 2102.105 0.8 292329.3* FOXO_KO.5 5.9108 0.5343 100 2603.438 2603.436 0.8 90673.7* FOXO_KO.3 5.933 0.3809 100 1733.889 1731.883 -0.5 499712.8* FOXO_KO.3 3.6208 0.2271 99.7 1733.889 1731.883 -0.7 282625.8* FOXO_KO.5 5.3108 0.47 100 2235.218 2233.215 -1.8 117190.8* FOXO_KO_w 2.6926 0.3519 100 1304.521 1304.521 -0.3 9118.4* FOXO_KO_w 3.5039 0.363 100 1305.522 1304.521 -2.1 185412.2* FOXO_KO.3 3.2203 0.3233 99.9 1066.543 1066.542 1.4 78391.4* FOXO_KO_w 2.8724 0.3359 99.9 1194.633 1194.637 -2.7 55597.5* FOXO_KO.2 4.6519 0.447 100 2201.115 2200.113 -0.9 157457.9* FOXO_KO.2 7.7561 0.577 100 2073.022 2072.018 0.3 264876.8* FOXO_KO.3 6.1625 0.5004 100 2158.981 2157.982 -2.3 202206.9* FOXO_KO.5 6.0482 0.4667 100 3329.635 3328.625 2 3199482* FOXO_KO.2 5.3348 0.5279 100 2122.879 2121.884 -3.9 50987.2IPI:IPI00 27 95 60.80% 255 29174 4.7 U Tax_Id=10090 Gene_Symbol=Ywhae 14-3-3 protein epsilon

FOXO_KO.1 5.3462 0.4783 100 1929.873 1928.873 -1.7 213910.8FOXO_KO.1 4.4263 0.4253 100 1928.869 1928.873 -2 400663.7FOXO_KO.1 5.7305 0.4088 100 2057.968 2056.968 -1.4 160002.3FOXO_KO.1 4.9425 0.3339 99.9 2057.968 2056.968 -1.5 203854.8FOXO_KO.1 3.8955 0.2528 99.9 2056.966 2056.968 -1.1 442426.4FOXO_KO.1 2.9151 0.3442 99.9 1131.471 1131.47 1.1 335581.5FOXO_KO.6 3.2331 0.3766 100 1259.564 1259.565 -0.5 109419.7FOXO_KO.7 3.3318 0.3378 99.9 1259.563 1259.565 -1.6 103207.8

FOXO_KO.2 4.5277 0.5066 100 1448.714 1447.71 0.4 259793.1FOXO_KO_w 4.7001 0.2943 100 1417.753 1417.753 0 61318.8FOXO_KO_w 6.2583 0.5306 100 1904.964 1903.961 0.2 22287.2FOXO_KO.7 6.6441 0.4735 100 2145.135 2145.14 -2.3 90433.3FOXO_KO.3 4.724 0.303 100 1477.745 1476.744 -1.4 308520.5FOXO_KO.3 5.6939 0.3605 100 2696.388 2695.379 1.9 198471.2FOXO_KO_w 3.3096 0.2763 99.9 1237.653 1237.654 -0.6 108695.1FOXO_KO.1 2.6176 0.335 100 1257.592 1256.591 -1.5 145706.1FOXO_KO.1 3.5244 0.3695 100 1384.684 1384.686 -1.3 249750.2

* FOXO_KO.1 3.8807 0.47 100 2561.269 2560.268 -1 181104.4* FOXO_KO.1 2.3746 0.3541 100 1194.599 1194.6 -1.1 121149.4* FOXO_KO.3 7.476 0.5247 100 2089.974 2087.966 0.6 522984.6* FOXO_KO.5 6.6564 0.575 100 3260.619 3258.609 1.2 108020.4* FOXO_KO.5 4.6873 0.5426 100 3258.614 3258.609 1.7 410381.8* FOXO_KO.5 4.8888 0.4403 100 3340.579 3338.575 -0.9 269059.7

FOXO_KO.5 7.1273 0.543 100 2244.124 2242.127 -4.5 356032.7* FOXO_KO.2 6.1823 0.5688 100 2180.942 2180.94 0.9 219063* FOXO_KO.2 3.7293 0.2835 99.8 3453.471 3451.471 -2.2 59052.9* FOXO_KO.2 4.2424 0.204 99.5 3452.475 3451.471 -0.1 99032.7IPI:IPI00 19 55 59.90% 247 28303 4.9 U Tax_Id=10090 Gene_Symbol=Ywhag 14-3-3 protein gamma

FOXO_KO.1 5.4088 0.4142 100 1813.826 1812.825 -1.6 340456.8FOXO_KO.1 4.3536 0.4607 100 1813.827 1812.825 -1.1 292589.1

* FOXO_KO.2 6.3279 0.4832 100 3438.596 3437.595 -0.5 100730.9* FOXO_KO.1 4.7459 0.326 100 1644.796 1643.787 3.2 116722.6* FOXO_KO.1 3.632 0.3745 99.9 1643.786 1643.787 -0.5 119026.6* FOXO_KO.5 6.7813 0.562 100 2606.384 2605.379 0.6 113176.9* FOXO_KO.5 5.1541 0.3776 100 2606.385 2605.379 0.9 206318.1* FOXO_KO.5 7.2713 0.5034 100 2236.163 2235.158 0.7 228722.7* FOXO_KO.5 4.2759 0.1961 99.7 2237.144 2235.158 -9.1 91369.5* FOXO_KO.4 4.5412 0.262 99.9 3463.641 3461.645 -3.2 66963* FOXO_KO_w 3.3053 0.3455 100 1236.657 1236.658 -1.1 70018.9* FOXO_KO.3 4.6708 0.5272 100 3012.503 3012.492 3.4 86381.2* FOXO_KO.3 6.8617 0.5845 100 2131.981 2130.971 2.8 192169.4* FOXO_KO.3 4.4865 0.441 100 2130.975 2130.971 1.6 259556.1* FOXO_KO.5 6.2186 0.5176 100 3303.623 3301.614 0.7 104512.6* FOXO_KO.5 3.583 0.3526 99.9 3302.621 3301.614 0.9 658692.4* FOXO_KO.4 3.9478 0.2554 99.7 3382.578 3381.581 -1.6 43837.8* FOXO_KO.5 4.9894 0.2439 99.9 3383.601 3381.581 4.1 184192.1* FOXO_KO.2 5.8438 0.4974 100 2194.882 2193.88 -1 46340.7IPI:IPI00 23 38 59.20% 245 27771 4.8 U Tax_Id=10090 Gene_Symbol=Ywhaz 14-3-3 protein zeta/delta

FOXO_KO.1 4.2795 0.3248 100 1901.823 1901.819 2.1 176995.6FOXO_KO.1 3.5285 0.4099 99.9 1901.82 1901.819 0.3 374715.6FOXO_KO.8 5.4052 0.4367 100 1548.708 1548.714 -3.4 4614811FOXO_KO.4 5.1837 0.4143 100 2418.263 2417.259 0.1 55981.2FOXO_KO.4 4.5521 0.3475 99.9 2418.266 2417.259 1.3 165720FOXO_KO.4 5.5231 0.3776 100 2160.121 2160.122 -0.1 118965.9FOXO_KO.5 5.7211 0.3963 100 3473.813 3471.804 0.7 78179.6FOXO_KO.3 3.8006 0.2525 99.9 1418.721 1418.72 1.4 199385.8

FOXO_KO.1 2.8198 0.2839 99.8 1330.7 1330.7 -0.2 210256.5FOXO_KO_w 4.1162 0.2625 99.9 1279.65 1279.653 -2.1 90539.7FOXO_KO_w 3.308 0.375 99.9 1279.653 1279.653 0.5 143481.4FOXO_KO.2 5.1779 0.2824 99.9 3302.624 3301.622 -0.6 64159.3FOXO_KO.2 3.2859 0.2896 99.7 3302.63 3301.622 1.3 190819.2FOXO_KO.2 4.4805 0.2502 99.9 3431.728 3429.717 1.1 104193.9FOXO_KO.2 8.1633 0.579 100 2170.082 2169.082 -1.8 81276.9FOXO_KO.2 3.9198 0.3055 99.9 2169.074 2169.082 -3.8 151934.8FOXO_KO.2 4.5317 0.429 100 2041.99 2040.987 -0.5 231072

* FOXO_KO.4 4.1691 0.4263 100 2132.993 2131.992 -0.9 82450.8* FOXO_KO.4 5.2153 0.5661 100 2132.996 2131.992 0.5 7454743* FOXO_KO.5 6.0337 0.5594 100 3303.635 3302.635 -1.1 137823.6* FOXO_KO.5 5.4296 0.4301 100 3303.639 3302.635 0.2 733813.7

FOXO_KO.5 7.1273 0.543 100 2244.124 2242.127 -4.5 356032.7* FOXO_KO.2 6.8148 0.6333 100 2410.001 2408.996 0.5 39252.9IPI:IPI008 20 51 57.40% 390 42795 5.2 U Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-1 of Protein phosphatase 1B

FOXO_KO.3 6.4972 0.471 100 3586.668 3584.665 -1.2 49191.8FOXO_KO.2 5.9736 0.5242 100 2420.129 2420.13 -0.2 61093.2FOXO_KO.2 3.7235 0.426 99.9 2420.125 2420.13 -2.2 240523.4FOXO_KO.1 3.071 0.2356 99.7 1289.657 1289.658 -0.9 421639.1FOXO_KO.9 4.3817 0.3175 100 2246.999 2245.013 -9.2 100579.2FOXO_KO.9 3.6046 0.3226 99.9 2532.143 2530.156 -7.8 197115.8FOXO_KO.2 5.3857 0.3883 100 2043.039 2042.044 -3.9 314812.9FOXO_KO.5 4.2512 0.3196 99.9 3335.473 3333.464 0.8 104922.7FOXO_KO.3 5.3356 0.4534 100 2303.991 2301.982 0.9 201676.8FOXO_KO.3 5.6769 0.4225 100 2789.312 2788.303 2.2 110522.5FOXO_KO.3 5.1104 0.3713 100 2546.174 2545.17 0.5 100030.5FOXO_KO.3 5.914 0.4446 100 2545.172 2545.17 1 1085752FOXO_KO.2 5.2477 0.446 100 1681.813 1680.808 1 226111.1FOXO_KO_w 3.5663 0.4519 100 1328.644 1328.644 -0.4 90453.1FOXO_KO_w 2.9163 0.2344 99.5 1328.645 1328.644 0.6 154302.4FOXO_KO.2 4.6949 0.4163 100 2186.077 2186.076 0.4 264645.9FOXO_KO.1 4.3732 0.5108 100 1528.686 1528.688 -1.7 236299.9FOXO_KO.1 2.4529 0.3332 99.7 1528.687 1528.688 -1.1 278680.8

* FOXO_KO.2 5.3989 0.503 100 2151.029 2150.036 -4.6 160646.8* FOXO_KO.2 3.0977 0.2795 99.6 2152.039 2150.036 -1.6 2331866IPI:IPI007 5 5 57.40% 115 11593 4.6 U Tax_Id=10090 Gene_Symbol=LOC100048062 similar to LOC665931 protein isoform 1

FOXO_KO.2 3.42 0.4502 100 1242.67 1242.669 1 37465FOXO_KO.2 4.315 0.4502 100 1242.668 1242.669 -0.8 232096.5FOXO_KO.1 3.4748 0.2429 99.5 3275.69 3274.691 -1.4 43193.1FOXO_KO.2 5.541 0.4457 100 1951.763 1949.759 -1.3 150481.6FOXO_KO.3 4.3836 0.4594 100 2109.691 2109.692 -0.2 90987.6

IPI:IPI00 4 8 57.30% 89 10435 4.9 U Tax_Id=10090 Gene_Symbol=Uqcrh Cytochrome b-c1 complex subunit 6, mitochondrial * FOXO_KO.2 4.1793 0.3468 99.9 2675.272 2674.276 -3 137133.2* FOXO_KO_w 3.3141 0.2464 99.9 1205.576 1204.574 -1.4 224202.3* FOXO_KO.3 5.1917 0.4673 100 2227.947 2226.961 -7.5 75884.6* FOXO_KO.3 4.1993 0.3907 99.9 2227.962 2226.961 -1 205677.2IPI:IPI003 19 49 56.20% 390 42888 5.3 U Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-4 of Protein phosphatase 1B


* FOXO_KO.1 4.3016 0.4369 100 1711.735 1710.731 0.1 88663IPI:IPI00 22 55 56.00% 477 52111 5.1 U Tax_Id=10090 Gene_Symbol=Ppm1b protein phosphatase 1B isoform 1


* FOXO_KO.1 6.5593 0.5464 100 2255.985 2254.981 0.6 29577.2* FOXO_KO.1 4.7467 0.3124 99.9 2255.984 2254.981 0.1 47843* FOXO_KO.1 6.1157 0.4456 100 2915.278 2914.276 -0.2 17826.6* FOXO_KO_w 3.7649 0.4402 100 1174.535 1174.533 1 23833.2IPI:IPI004 12 40 55.90% 245 27778 4.8 U Tax_Id=10090 Gene_Symbol=Ywhaq Isoform 1 of 14-3-3 protein theta IPI:IPI00 12 40 45.20% 303 34349 6.4 U Tax_Id=10090 Gene_Symbol=Ywhaq 34 kDa protein

FOXO_KO.1 2.8386 0.2568 99.6 1931.826 1931.83 -1.9 137479.2FOXO_KO_w 5.6897 0.4948 100 1532.718 1532.719 -0.6 69930.7FOXO_KO.3 3.1087 0.3647 100 1391.746 1391.745 0.4 125250.2FOXO_KO.4 4.0301 0.25 99.7 2694.415 2693.407 1.8 76539.4

FOXO_KO.9 3.6169 0.324 100 1268.555 1268.558 -1.7 750942.8FOXO_KO_w 4.3571 0.4352 100 1396.651 1396.653 -1.1 54880FOXO_KO.1 7.7977 0.5474 100 2158.047 2157.046 -0.9 118500.4FOXO_KO.1 5.437 0.4251 100 2286.144 2285.141 -0.1 198856.9FOXO_KO.1 5.7757 0.1958 100 2028.95 2028.951 -0.7 122135FOXO_KO.3 4.0415 0.4686 100 2145.97 2144.987 -9.6 71839.9FOXO_KO.5 5.5598 0.4901 100 3316.639 3315.63 1.6 211462.2FOXO_KO.2 2.8534 0.4805 100 2454.977 2454.984 -2.9 10709.6

IPI:IPI00 11 14 54.50% 279 31025 4.9 U Tax_Id=10090 Gene_Symbol=C1qbp complement component 1, q subcomponent binding protein FOXO_KO.3 8.1483 0.5304 100 2479.239 2478.24 -1.6 46421.2FOXO_KO.3 6.4609 0.507 100 2479.24 2478.24 -1.5 243674.4FOXO_KO.2 4.9226 0.4778 100 1697.865 1697.863 1.1 202723.1FOXO_KO.1 4.8799 0.4672 100 1665.743 1665.742 0.2 225761.2

* FOXO_KO.2 5.2904 0.4856 100 2248.106 2247.103 0 86774* FOXO_KO.2 3.6159 0.4142 99.9 2249.109 2247.103 -0.2 109185

FOXO_KO.2 6.8003 0.5145 100 3161.422 3161.426 -1.1 112053.6FOXO_KO.1 2.9378 0.3653 99.9 1511.675 1511.676 -0.6 165243.4FOXO_KO.5 4.4885 0.5364 100 3119.419 3118.41 1.7 29931.6FOXO_KO.5 4.3307 0.414 100 3120.421 3118.41 1.4 104493.8FOXO_KO.5 4.4216 0.2833 99.9 3440.69 3439.679 2.3 27071.4

IPI:IPI002 18 47 50.50% 402 44271 5.1 U Tax_Id=10090 Gene_Symbol=Ppm1b;LOC100048520 Isoform Beta-5 of Protein phosphatase 1B IPI:IPI008 18 48 52.20% 389 42980 5.6 U Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-2 of Protein phosphatase 1B IPI:IPI004 18 48 51.70% 393 43413 5.3 U Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-3 of Protein phosphatase 1B


IPI:IPI00 14 34 50.40% 246 28086 4.8 U Tax_Id=10090 Gene_Symbol=Ywhab Isoform Long of 14-3-3 protein beta/alpha IPI:IPI00 14 34 50.80% 244 27854 4.8 U Tax_Id=10090 Gene_Symbol=Ywhab Isoform Short of 14-3-3 protein beta/alpha

FOXO_KO.1 5.4088 0.4142 100 1813.826 1812.825 -1.6 340456.8FOXO_KO.1 4.3536 0.4607 100 1813.827 1812.825 -1.1 292589.1FOXO_KO.4 4.6294 0.456 100 1598.738 1598.741 -1.6 63013FOXO_KO.4 2.7176 0.2922 99.7 1598.74 1598.741 -0.1 246720.9FOXO_KO.5 7.4777 0.4776 100 2388.205 2387.201 0.2 118836.7

FOXO_KO.5 5.2819 0.3849 100 2388.206 2387.201 0.7 140762FOXO_KO.5 7.6702 0.5876 100 3720.918 3718.909 0.4 60869.4FOXO_KO.4 6.4865 0.3995 100 2131.05 2130.064 -7.8 78427FOXO_KO.4 5.8225 0.4659 100 2131.073 2130.064 3 160493.9FOXO_KO.5 4.7919 0.4672 100 3462.782 3461.772 1.8 52006.1FOXO_KO_w 3.5066 0.3523 100 1196.579 1196.579 -0.3 85774.4FOXO_KO.3 6.5757 0.4606 100 2161.01 2159.003 0.1 189942.9FOXO_KO.5 5.1985 0.5687 100 3331.637 3329.646 -4.6 79822.3FOXO_KO.2 5.9832 0.5005 100 2351.958 2350.954 0.2 53353.8

IPI:IPI00 37 105 48.30% 611 68840 5.7 U Tax_Id=10090 Gene_Symbol=Eif4b Eukaryotic translation initiation factor 4B * FOXO_KO.3 5.0695 0.5638 100 2287.118 2286.114 0.5 61882* FOXO_KO.3 5.9317 0.4621 100 3224.352 3224.356 -1.4 86400.9* FOXO_KO.3 4.3787 0.3567 99.9 3226.358 3224.356 -1.5 221813.6* FOXO_KO.3 4.8719 0.3429 99.9 2990.486 2988.475 1.3 81290.8* FOXO_KO.3 4.9162 0.4431 100 2990.477 2988.475 -1.6 118560.8* FOXO_KO.3 4.235 0.4877 100 2408.119 2407.11 2.3 53117.1* FOXO_KO.3 4.8739 0.5118 100 2408.114 2407.11 0 48847* FOXO_KO.4 5.0354 0.5143 100 2893.419 2892.409 2.5 33148.1* FOXO_KO.4 6.2073 0.5132 100 2893.415 2892.409 0.9 329595.4* FOXO_KO.4 5.0773 0.3667 99.9 3344.683 3343.68 -0.3 90485.5* FOXO_KO.4 4.3074 0.2164 99.7 3344.687 3343.68 0.8 254654.5* FOXO_KO.5 5.8219 0.4203 100 2948.4 2946.4 -2.4 22211* FOXO_KO.5 6.1725 0.4569 100 2948.396 2946.4 -3.8 98306* FOXO_KO.4 5.0895 0.4617 100 3103.506 3102.502 0.3 79614.6* FOXO_KO.4 4.807 0.3491 100 2015.991 2014.99 -1 101267.3* FOXO_KO.2 3.3682 0.2646 99.7 2014.993 2014.99 1.5 528840.8* FOXO_KO.3 4.2972 0.388 100 2014.989 2014.99 -0.7 1539572* FOXO_KO.2 3.1775 0.3869 100 1508.674 1508.672 0.8 40892.7* FOXO_KO.1 2.2928 0.3807 100 1238.528 1238.528 0 29401.9* FOXO_KO.1 3.1729 0.2941 99.9 1238.527 1238.528 -1 1379481* FOXO_KO.1 2.8593 0.4355 99.9 1238.529 1238.528 0.5 168396.7* FOXO_KO.1 3.5638 0.4358 100 1638.759 1637.755 0.3 174426.9* FOXO_KO.1 2.6414 0.2659 99.5 1637.756 1637.755 0.2 165027.3* FOXO_KO.1 2.9839 0.301 99.8 1717.726 1717.722 2.6 44152.5* FOXO_KO.1 3.0214 0.4237 100 1717.722 1717.722 0.3 81832.3* FOXO_KO.1 3.1651 0.523 100 1717.707 1717.722 -8.5 78279.5* FOXO_KO.1 5.5663 0.5491 100 1723.773 1723.773 0.1 336230* FOXO_KO.1 3.9535 0.5177 100 1806.76 1806.761 -0.5 81754.7* FOXO_KO.1 2.7745 0.3931 99.9 1563.625 1563.628 -1.8 241725.2* FOXO_KO.1 2.6515 0.3557 99.8 1563.627 1563.628 -0.9 280514.4* FOXO_KO.1 4.6097 0.3985 100 3220.551 3218.563 -6 57903.3* FOXO_KO.1 4.0627 0.4889 100 1729.69 1729.691 -0.6 147803.2* FOXO_KO.2 4.6921 0.5092 100 1729.688 1729.691 -1.7 137596.8* FOXO_KO.9 3.8903 0.3143 99.9 3176.458 3175.454 0.3 48307.2* FOXO_KO.8 7.0525 0.5724 100 2006.932 2005.936 -3.3 756303.3* FOXO_KO_w 2.5684 0.2856 99.8 1084.517 1084.517 -0.2 157225.8* FOXO_KO.1 3.9002 0.5017 100 2089.768 2089.766 0.9 33436.4IPI:IPI00 2 4 48.30% 60 6759 9.4 U Tax_Id=10090 Gene_Symbol=Wdr77 7 kDa protein

FOXO_KO.1 3.1937 0.2537 99.8 1725.884 1725.887 -1.6 86063.7FOXO_KO.1 3.5532 0.3309 99.9 1685.759 1684.757 -0.9 139681.6

IPI:IPI007 9 10 47.50% 278 31013 4.9 U Tax_Id=10090 Gene_Symbol=C1qbp Complement component 1 Q subcomponent-binding protein, mitochondrial FOXO_KO.3 8.1483 0.5304 100 2479.239 2478.24 -1.6 46421.2FOXO_KO.3 6.4609 0.507 100 2479.24 2478.24 -1.5 243674.4FOXO_KO.2 4.9226 0.4778 100 1697.865 1697.863 1.1 202723.1FOXO_KO.1 4.8799 0.4672 100 1665.743 1665.742 0.2 225761.2FOXO_KO.2 6.8003 0.5145 100 3161.422 3161.426 -1.1 112053.6FOXO_KO.1 2.9378 0.3653 99.9 1511.675 1511.676 -0.6 165243.4FOXO_KO.5 4.4885 0.5364 100 3119.419 3118.41 1.7 29931.6FOXO_KO.5 4.3307 0.414 100 3120.421 3118.41 1.4 104493.8FOXO_KO.5 4.4216 0.2833 99.9 3440.69 3439.679 2.3 27071.4

IPI:IPI006 11 38 46.90% 243 27701 4.9 U Tax_Id=10090 Gene_Symbol=Ywhaq Isoform 2 of 14-3-3 protein theta FOXO_KO.1 2.8386 0.2568 99.6 1931.826 1931.83 -1.9 137479.2FOXO_KO_w 5.6897 0.4948 100 1532.718 1532.719 -0.6 69930.7FOXO_KO.3 3.1087 0.3647 100 1391.746 1391.745 0.4 125250.2FOXO_KO.4 4.0301 0.25 99.7 2694.415 2693.407 1.8 76539.4FOXO_KO.9 3.6169 0.324 100 1268.555 1268.558 -1.7 750942.8FOXO_KO_w 4.3571 0.4352 100 1396.651 1396.653 -1.1 54880FOXO_KO.1 7.7977 0.5474 100 2158.047 2157.046 -0.9 118500.4FOXO_KO.1 5.437 0.4251 100 2286.144 2285.141 -0.1 198856.9FOXO_KO.1 5.7757 0.1958 100 2028.95 2028.951 -0.7 122135FOXO_KO.3 4.0415 0.4686 100 2145.97 2144.987 -9.6 71839.9FOXO_KO.5 5.5598 0.4901 100 3316.639 3315.63 1.6 211462.2

IPI:IPI00 13 68 46.90% 130 15220 5.2 U Tax_Id=10090 Gene_Symbol=Ywhae 15 kDa protein FOXO_KO.1 5.3462 0.4783 100 1929.873 1928.873 -1.7 213910.8FOXO_KO.1 4.4263 0.4253 100 1928.869 1928.873 -2 400663.7FOXO_KO.1 5.7305 0.4088 100 2057.968 2056.968 -1.4 160002.3FOXO_KO.1 4.9425 0.3339 99.9 2057.968 2056.968 -1.5 203854.8FOXO_KO.1 3.8955 0.2528 99.9 2056.966 2056.968 -1.1 442426.4FOXO_KO.1 2.9151 0.3442 99.9 1131.471 1131.47 1.1 335581.5FOXO_KO.6 3.2331 0.3766 100 1259.564 1259.565 -0.5 109419.7FOXO_KO.7 3.3318 0.3378 99.9 1259.563 1259.565 -1.6 103207.8FOXO_KO.2 4.5277 0.5066 100 1448.714 1447.71 0.4 259793.1FOXO_KO_w 4.7001 0.2943 100 1417.753 1417.753 0 61318.8FOXO_KO_w 6.2583 0.5306 100 1904.964 1903.961 0.2 22287.2FOXO_KO.7 6.6441 0.4735 100 2145.135 2145.14 -2.3 90433.3FOXO_KO.3 4.724 0.303 100 1477.745 1476.744 -1.4 308520.5

IPI:IPI00 6 34 46.70% 214 24741 10.1 U Tax_Id=10090 Gene_Symbol=Ybx1 Y box protein 1 FOXO_KO.8 5.8959 0.5841 100 3258.393 3257.396 -1.9 170959.7FOXO_KO.1 6.1157 0.4254 100 2872.312 2871.307 0.3 79844.5FOXO_KO.1 5.0619 0.5361 100 2629.101 2628.104 -2.4 24150.7FOXO_KO.1 4.1766 0.3771 99.9 2630.089 2628.104 -8.1 116408.8FOXO_KO.1 3.8922 0.237 99.7 2785.208 2784.205 -0.1 55205.6FOXO_KO_w 2.7488 0.3706 99.9 1897.801 1897.805 -1.9 5747

IPI:IPI00 11 26 45.90% 159 18349 5.5 U Tax_Id=10090 Gene_Symbol=Ywhab Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta FOXO_KO.1 5.4088 0.4142 100 1813.826 1812.825 -1.6 340456.8FOXO_KO.1 4.3536 0.4607 100 1813.827 1812.825 -1.1 292589.1

FOXO_KO.4 4.6294 0.456 100 1598.738 1598.741 -1.6 63013FOXO_KO.4 2.7176 0.2922 99.7 1598.74 1598.741 -0.1 246720.9FOXO_KO.5 7.4777 0.4776 100 2388.205 2387.201 0.2 118836.7FOXO_KO.5 5.2819 0.3849 100 2388.206 2387.201 0.7 140762FOXO_KO.5 7.6702 0.5876 100 3720.918 3718.909 0.4 60869.4FOXO_KO.4 6.4865 0.3995 100 2131.05 2130.064 -7.8 78427FOXO_KO.4 5.8225 0.4659 100 2131.073 2130.064 3 160493.9FOXO_KO.5 4.7919 0.4672 100 3462.782 3461.772 1.8 52006.1FOXO_KO_w 3.5066 0.3523 100 1196.579 1196.579 -0.3 85774.4

IPI:IPI00 8 45 44.70% 342 36943 5.3 U Tax_Id=10090 Gene_Symbol=Wdr77 Methylosome protein 50 FOXO_KO.1 3.1937 0.2537 99.8 1725.884 1725.887 -1.6 86063.7FOXO_KO.1 3.5532 0.3309 99.9 1685.759 1684.757 -0.9 139681.6

* FOXO_KO.3 6.2674 0.4221 100 3051.391 3049.384 -0.1 23597.6* FOXO_KO.3 4.7691 0.3957 100 3051.391 3049.384 0 60711.7* FOXO_KO.3 4.9985 0.3367 100 2789.442 2787.43 1.9 12311.8

FOXO_KO.2 3.9131 0.5053 100 2480.207 2480.215 -3.2 109271.3FOXO_KO.1 3.0859 0.383 100 1401.596 1401.595 0.4 174795.5

* FOXO_KO.5 3.2403 0.267 99.5 3505.796 3504.793 -0.1 56471.4IPI:IPI00 9 53 44.20% 154 17365 9.2 U Tax_Id=10090 Gene_Symbol=Ywhae Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

FOXO_KO.2 4.5277 0.5066 100 1448.714 1447.71 0.4 259793.1FOXO_KO_w 4.7001 0.2943 100 1417.753 1417.753 0 61318.8FOXO_KO_w 6.2583 0.5306 100 1904.964 1903.961 0.2 22287.2FOXO_KO.7 6.6441 0.4735 100 2145.135 2145.14 -2.3 90433.3FOXO_KO.3 4.724 0.303 100 1477.745 1476.744 -1.4 308520.5FOXO_KO.3 5.6939 0.3605 100 2696.388 2695.379 1.9 198471.2FOXO_KO_w 3.3096 0.2763 99.9 1237.653 1237.654 -0.6 108695.1FOXO_KO.1 2.6176 0.335 100 1257.592 1256.591 -1.5 145706.1FOXO_KO.1 3.5244 0.3695 100 1384.684 1384.686 -1.3 249750.2

IPI:IPI00 17 27 44.10% 211 24158 6.8 U Tax_Id=10090 Gene_Symbol=LOC100047236 similar to 14-3-3 zeta FOXO_KO.1 4.2795 0.3248 100 1901.823 1901.819 2.1 176995.6FOXO_KO.1 3.5285 0.4099 99.9 1901.82 1901.819 0.3 374715.6FOXO_KO.8 5.4052 0.4367 100 1548.708 1548.714 -3.4 4614811FOXO_KO.4 5.1837 0.4143 100 2418.263 2417.259 0.1 55981.2FOXO_KO.4 4.5521 0.3475 99.9 2418.266 2417.259 1.3 165720FOXO_KO.4 5.5231 0.3776 100 2160.121 2160.122 -0.1 118965.9FOXO_KO.5 5.7211 0.3963 100 3473.813 3471.804 0.7 78179.6FOXO_KO.3 3.8006 0.2525 99.9 1418.721 1418.72 1.4 199385.8FOXO_KO.1 2.8198 0.2839 99.8 1330.7 1330.7 -0.2 210256.5FOXO_KO_w 4.1162 0.2625 99.9 1279.65 1279.653 -2.1 90539.7FOXO_KO_w 3.308 0.375 99.9 1279.653 1279.653 0.5 143481.4FOXO_KO.2 5.1779 0.2824 99.9 3302.624 3301.622 -0.6 64159.3FOXO_KO.2 3.2859 0.2896 99.7 3302.63 3301.622 1.3 190819.2FOXO_KO.2 4.4805 0.2502 99.9 3431.728 3429.717 1.1 104193.9FOXO_KO.2 8.1633 0.579 100 2170.082 2169.082 -1.8 81276.9FOXO_KO.2 3.9198 0.3055 99.9 2169.074 2169.082 -3.8 151934.8FOXO_KO.2 4.5317 0.429 100 2041.99 2040.987 -0.5 231072

IPI:IPI00 10 34 43.90% 287 32250 4.9 U Tax_Id=10090 Gene_Symbol=Gm2423 similar to Ywhaq protein FOXO_KO.1 2.8386 0.2568 99.6 1931.826 1931.83 -1.9 137479.2

FOXO_KO_w 5.6897 0.4948 100 1532.718 1532.719 -0.6 69930.7FOXO_KO.3 3.1087 0.3647 100 1391.746 1391.745 0.4 125250.2FOXO_KO.4 4.0301 0.25 99.7 2694.415 2693.407 1.8 76539.4FOXO_KO.1 7.7977 0.5474 100 2158.047 2157.046 -0.9 118500.4FOXO_KO.1 5.437 0.4251 100 2286.144 2285.141 -0.1 198856.9FOXO_KO.1 5.7757 0.1958 100 2028.95 2028.951 -0.7 122135FOXO_KO.3 4.0415 0.4686 100 2145.97 2144.987 -9.6 71839.9FOXO_KO.5 5.5598 0.4901 100 3316.639 3315.63 1.6 211462.2FOXO_KO.2 2.8534 0.4805 100 2454.977 2454.984 -2.9 10709.6

IPI:IPI00 4 7 43.90% 82 9768 10.3 U Tax_Id=10090 Gene_Symbol=Uqcrq Cytochrome b-c1 complex subunit 8 * FOXO_KO.5 4.7341 0.4638 100 3098.665 3096.656 0.7 30978.8* FOXO_KO.5 3.6765 0.3025 99.9 2715.392 2714.387 0.7 2821.5* FOXO_KO.5 3.9788 0.3009 99.9 2716.399 2714.387 2.3 39476.4

FOXO_KO.2 3.4482 0.3739 100 1209.556 1209.557 -0.4 28178IPI:IPI00 3 3 43.70% 71 8386 4.6 U Tax_Id=10090 Gene_Symbol=Tpm3 8 kDa protein

FOXO_KO.1 5.8194 0.4341 100 1945.03 1945.031 -0.4 187997.5FOXO_KO.1 3.5628 0.2809 99.9 1284.75 1284.752 -1.6 249361.9FOXO_KO.1 4.4374 0.4257 100 1799.984 1799.986 -1.4 74303.1

IPI:IPI00 14 26 43.30% 423 47538 5.3 U Tax_Id=10090 Gene_Symbol=Krt18 Keratin, type I cytoskeletal 18 * FOXO_KO.9 6.0789 0.1516 99.9 1888.87 1887.871 -2 230926.1* FOXO_KO.2 3.5136 0.2318 99.5 3152.478 3151.478 -1.2 50646.3* FOXO_KO.1 2.665 0.3324 99.9 1121.489 1121.489 -0.2 355594.4

FOXO_KO.4 7.5587 0.5408 100 2178.183 2177.177 0.9 164479.5* FOXO_KO.2 7.4246 0.0952 99.9 2751.346 2750.348 -1.8 18123.1* FOXO_KO.2 5.0816 0.1598 99.5 2751.35 2750.348 -0.4 151321.7* FOXO_KO.3 5.1419 0.4017 100 3273.629 3273.627 0.8 85551* FOXO_KO.1 5.2624 0.3861 100 1785.869 1785.873 -2.3 169201.3* FOXO_KO.3 4.6926 0.374 100 2382.219 2380.229 -6.9 91816.9* FOXO_KO.3 3.2427 0.2394 99.5 2380.231 2380.229 0.8 232078.5

FOXO_KO.2 4.3751 0.3321 100 1420.753 1419.748 1.6 252901.8* FOXO_KO.2 4.6963 0.332 100 2913.359 2912.358 -0.8 37734* FOXO_KO.2 5.4448 0.4538 100 2914.345 2912.358 -6.7 155902.4* FOXO_KO.2 5.6685 0.528 100 2758.249 2756.257 -5.2 20415.5IPI:IPI00 12 17 42.80% 292 32560 4.8 U Tax_Id=10090 Gene_Symbol=Npm1 Nucleophosmin IPI:IPI00 12 17 42.80% 292 32666 4.8 U Tax_Id=10090 Gene_Symbol=LOC100046628 similar to Nucleophosmin IPI:IPI00 12 17 43.90% 285 31723 4.8 U Tax_Id=10090 Gene_Symbol=Npm1 Nucleophosmin 1 IPI:IPI00 12 17 48.60% 257 28385 4.7 U Tax_Id=10090 Gene_Symbol=Npm1 Putative uncharacterized protein IPI:IPI00 12 17 47.30% 264 29525 4.6 U Tax_Id=10090 Gene_Symbol=Npm1 Nucleophosmin 1

FOXO_KO.1 7.2234 0.4881 100 2575.186 2573.201 -8.8 104707.5FOXO_KO.7 3.2443 0.399 99.9 1568.728 1568.73 -1.3 539482.4FOXO_KO.3 4.8739 0.3409 99.9 2930.463 2929.461 -0.6 82699.4FOXO_KO.2 6.3012 0.4 100 2145.014 2145.017 -1.5 219432.7FOXO_KO.1 4.5381 0.3566 99.9 3447.421 3446.421 -1 65217FOXO_KO.2 6.0613 0.4127 100 4133.799 4132.8 -0.9 74879.8FOXO_KO.1 4.2833 0.4915 100 4406.661 4404.645 2.1 16173.2FOXO_KO.1 5.3722 0.3914 100 4406.647 4404.645 -1 52472.8FOXO_KO.1 2.8739 0.3293 99.7 4533.74 4532.74 -0.6 12777.6FOXO_KO.1 4.7959 0.4354 100 4534.748 4532.74 0.4 100301.8

FOXO_KO.1 4.2935 0.4377 100 4534.74 4532.74 -1.4 494286.3FOXO_KO.1 4.4926 0.2423 99.8 4306.581 4305.576 0.4 67908

IPI:IPI00 1 1 42.60% 61 6875 6 U Tax_Id=10090 Gene_Symbol=Thrap3 Thrap3 protein FOXO_KO.1 5.2974 0.4165 100 3184.208 3183.21 -1.7 44842.9

IPI:IPI00 8 37 42.20% 322 35730 9.9 U Tax_Id=10090 Gene_Symbol=Ybx1 Nuclease-sensitive element-binding protein 1 IPI:IPI00 8 37 41.80% 325 36637 9.8 U Tax_Id=10090 Gene_Symbol=LOC100045189 similar to transcription factor EF1

FOXO_KO.2 6.2205 0.4505 100 1796.825 1795.823 -1 263572.8FOXO_KO.2 4.4214 0.4577 100 3473.676 3472.671 0.2 118173.7FOXO_KO.8 5.8959 0.5841 100 3258.393 3257.396 -1.9 170959.7FOXO_KO.1 6.1157 0.4254 100 2872.312 2871.307 0.3 79844.5FOXO_KO.1 5.0619 0.5361 100 2629.101 2628.104 -2.4 24150.7FOXO_KO.1 4.1766 0.3771 99.9 2630.089 2628.104 -8.1 116408.8FOXO_KO.1 3.8922 0.237 99.7 2785.208 2784.205 -0.1 55205.6FOXO_KO_w 2.7488 0.3706 99.9 1897.801 1897.805 -1.9 5747

IPI:IPI00 3 3 41.90% 86 10071 8.7 U Tax_Id=10090 Gene_Symbol=Cox6b1 Cytochrome c oxidase subunit 6B1 * FOXO_KO.2 3.5001 0.2811 99.9 1552.675 1552.675 -0.2 188758.6* FOXO_KO.1 2.9288 0.3244 99.9 1327.573 1327.574 -0.6 237483.9* FOXO_KO.3 4.8767 0.4623 100 1677.766 1677.769 -2 240200.9IPI:IPI00 8 11 40.50% 264 29885 9.7 U Tax_Id=10090 Gene_Symbol=Rps3a 40S ribosomal protein S3a IPI:IPI00 8 11 40.50% 264 29825 9.7 U Tax_Id=10090 Gene_Symbol=Gm10119 similar to ribosomal protein S3a

FOXO_KO.1 2.3221 0.2914 99.8 825.3773 825.3778 -0.6 323035.7FOXO_KO.3 5.5092 0.5279 100 1952.978 1951.976 -0.6 97560.1FOXO_KO_w 3.2437 0.2951 99.9 1002.546 1002.547 -0.8 69215.3FOXO_KO.1 4.3162 0.2724 100 1579.714 1578.715 -2.7 343276.2FOXO_KO.3 4.4005 0.441 100 2824.532 2824.53 0.5 136584.5FOXO_KO_w 3.7794 0.405 100 1302.618 1301.615 -0.8 116257.7FOXO_KO.1 4.8327 0.4743 100 2475.161 2475.163 -1.1 41769.8FOXO_KO.1 2.9334 0.31 99.9 1290.584 1290.585 -0.4 208173.1

IPI:IPI00 7 15 40.00% 145 17040 10.4 U Tax_Id=10090 Gene_Symbol=Rps15 40S ribosomal protein S15 IPI:IPI00 7 15 46.80% 124 14701 10.5 U Tax_Id=10090 Gene_Symbol=Rps15 Putative uncharacterized protein

FOXO_KO.5 4.1472 0.4202 99.9 3157.523 3155.518 -0.5 43512.8FOXO_KO.5 6.0963 0.5634 100 2275.066 2274.067 -2 41134.2FOXO_KO.5 6.0848 0.5359 100 2589.237 2588.237 -1.4 24386.2FOXO_KO.5 6.6786 0.4309 100 2590.241 2588.237 -1.3 65976.6FOXO_KO_w 4.0933 0.4277 100 1481.801 1481.803 -1.3 52404.4FOXO_KO.8 3.4335 0.3056 99.9 1353.704 1353.708 -3 284062FOXO_KO.4 4.7739 0.4423 100 2054.003 2053.017 -8.4 71482.1

IPI:IPI00 7 23 39.70% 234 26164 5.9 U Tax_Id=10090 Gene_Symbol=Kctd5 BTB/POZ domain-containing protein KCTD5 * FOXO_KO.1 5.8962 0.5621 100 2511.137 2510.135 -0.6 54739.3* FOXO_KO.1 5.4021 0.3968 100 2511.137 2510.135 -0.7 189166* FOXO_KO.3 3.5714 0.4122 99.9 4047.918 4045.912 -0.3 15560.6* FOXO_KO.3 3.9873 0.3858 99.9 4047.92 4045.912 0.3 1394155* FOXO_KO.4 7.5372 0.5573 100 2385.199 2383.191 0.4 71886.7

FOXO_KO.3 6.1133 0.5431 100 2500.127 2499.12 1.4 29153.9* FOXO_KO_w 5.3857 0.5082 100 1789.822 1789.824 -0.8 85133.4IPI:IPI00 5 19 39.50% 195 21694 4.7 U Tax_Id=10090 Gene_Symbol=Pgrmc1 Membrane-associated progesterone receptor component 1 * FOXO_KO.1 4.9591 0.2948 100 2418.134 2417.133 -0.8 42752.6* FOXO_KO.1 6.2119 0.5526 100 2049.881 2048.879 -0.7 76039.7

* FOXO_KO.3 5.0759 0.4251 100 3635.651 3635.655 -1.1 62806.6* FOXO_KO.1 4.879 0.3009 99.9 2730.201 2730.203 -0.6 92904.4* FOXO_KO.1 3.9864 0.3799 100 2376.94 2375.94 -1.4 43762IPI:IPI00 6 6 39.50% 172 19779 4.8 U Tax_Id=10090 Gene_Symbol=Myl12b Myosin regulatory light chain 12B

FOXO_KO.1 2.9561 0.3844 100 1237.56 1237.563 -2.5 232629.8FOXO_KO.3 3.2954 0.2835 99.7 2003.971 2003.974 -1.4 269817.1

* FOXO_KO.3 6.4373 0.5272 100 2351.034 2350.029 0.5 117413.3FOXO_KO.2 4.8978 0.2517 100 2433.131 2432.128 -0.2 94538.5FOXO_KO.2 3.8695 0.3953 99.9 2433.129 2432.128 -1.1 169231FOXO_KO.1 4.0631 0.3864 100 1415.632 1415.632 -0.3 300836.3

IPI:IPI00 14 20 39.20% 352 39503 5.1 U Tax_Id=10090 Gene_Symbol=Tmod3 Tropomodulin-3 * FOXO_KO.1 6.4159 0.478 100 1966.966 1965.965 -1.1 155793.8* FOXO_KO.2 3.8913 0.3054 99.9 1837.87 1837.87 0.1 626589.6* FOXO_KO.3 6.1628 0.4461 100 2625.284 2624.283 -0.8 75223.6* FOXO_KO.2 4.7611 0.2902 99.9 2705.246 2704.249 -2.3 145824.7* FOXO_KO.4 5.5654 0.5248 100 2326.195 2326.192 1.3 2371989* FOXO_KO.8 4.2688 0.4471 100 2165.025 2164.031 -4.3 68257.5* FOXO_KO.1 4.1856 0.4425 100 1457.654 1457.654 0.1 182846.2* FOXO_KO.3 5.362 0.4848 100 2139.104 2138.102 -0.3 106824.8* FOXO_KO.2 4.201 0.4603 100 2294.208 2294.203 2.1 78965.4* FOXO_KO.1 3.3271 0.3352 100 1156.676 1155.673 -0.9 591385.5* FOXO_KO.3 3.8453 0.492 100 1477.737 1477.736 0.8 150339.1* FOXO_KO.5 4.6466 0.4561 100 3380.728 3378.728 -2 61190.2* FOXO_KO.5 5.8452 0.4964 100 3380.743 3378.728 2.3 104802.2* FOXO_KO.1 2.8998 0.2399 99.8 1092.524 1092.524 -0.3 178838.9IPI:IPI00 9 15 39.00% 218 26169 5.4 U Tax_Id=10090 Gene_Symbol=Myh9 Myh9 protein (Fragment)

FOXO_KO.2 4.6915 0.3902 100 1769.814 1769.812 1.1 120547.4FOXO_KO.3 5.276 0.462 100 2503.206 2501.219 -7.8 58461.1FOXO_KO.1 5.1653 0.4103 100 1769.847 1769.849 -0.9 164171.1FOXO_KO.2 6.5668 0.5031 100 2462.156 2461.151 0.6 51749.1FOXO_KO.2 4.0384 0.3274 99.9 2462.156 2461.151 0.7 162920.1FOXO_KO.2 4.5224 0.3708 99.9 2334.061 2333.056 0.8 180765.8FOXO_KO.1 6.6611 0.5576 100 1892.874 1892.873 0.4 107355.6FOXO_KO.1 4.3193 0.284 99.9 1894.884 1892.873 2.1 309522.2FOXO_KO.1 5.6316 0.4712 100 1764.779 1764.778 0.6 157325.2

IPI:IPI00 16 20 37.70% 284 32820 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 5 IPI:IPI00 16 20 37.70% 284 32848 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 4

FOXO_KO.1 5.2443 0.403 100 2410.194 2410.198 -1.7 225002.4FOXO_KO.1 4.4004 0.3978 100 1597.758 1597.759 -0.8 184975.1FOXO_KO.1 5.3613 0.4842 100 2169.019 2169.019 0 50497.7FOXO_KO.3 5.3341 0.452 100 2853.407 2852.405 -0.3 129960.5FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9FOXO_KO.1 3.8103 0.3227 99.9 1960.006 1960.006 0.1 332255.9FOXO_KO.1 4.0147 0.3765 100 1315.767 1314.763 0.3 257598

FOXO_KO.1 4.389 0.2889 100 1800.986 1799.986 -2.2 139234.9FOXO_KO.1 3.8697 0.3464 99.9 1799.984 1799.986 -1.2 369849FOXO_KO.1 3.5517 0.2115 99.8 1673.895 1671.891 -1.8 211568.5FOXO_KO.1 6.1221 0.473 100 2520.204 2518.202 -1.9 23991.6FOXO_KO.1 5.2574 0.367 100 2519.202 2518.202 -1.3 203517.6

IPI:IPI00 4 6 37.20% 145 17054 10.4 U Tax_Id=10090 Gene_Symbol=Rps15 Putative uncharacterized protein * FOXO_KO.5 2.9533 0.2515 99.6 2604.235 2602.253 -9.4 19762.8

FOXO_KO_w 4.0933 0.4277 100 1481.801 1481.803 -1.3 52404.4FOXO_KO.8 3.4335 0.3056 99.9 1353.704 1353.708 -3 284062FOXO_KO.4 4.7739 0.4423 100 2054.003 2053.017 -8.4 71482.1

IPI:IPI00 7 8 37.10% 264 29859 9.7 U Tax_Id=10090 Gene_Symbol=Gm9000 similar to ribosomal protein S3a FOXO_KO.1 2.3221 0.2914 99.8 825.3773 825.3778 -0.6 323035.7FOXO_KO.3 5.5092 0.5279 100 1952.978 1951.976 -0.6 97560.1FOXO_KO.1 4.3162 0.2724 100 1579.714 1578.715 -2.7 343276.2FOXO_KO.3 4.4005 0.441 100 2824.532 2824.53 0.5 136584.5FOXO_KO_w 3.7794 0.405 100 1302.618 1301.615 -0.8 116257.7FOXO_KO.1 4.8327 0.4743 100 2475.161 2475.163 -1.1 41769.8FOXO_KO.1 2.9334 0.31 99.9 1290.584 1290.585 -0.4 208173.1

contamina 25 68 36.90% 607 69271 6.1 U BSA * FOXO_KO.2 3.4005 0.3407 100 1419.695 1419.694 1.2 177991.9* FOXO_KO.2 4.1664 0.3199 99.9 1420.695 1419.694 -1.4 269679.4* FOXO_KO_w 3.9446 0.506 100 1479.526 1478.523 -0.3 90606.5* FOXO_KO.1 3.583 0.2479 99.8 2542.171 2541.168 -0.1 35531.5* FOXO_KO.1 4.7291 0.2993 99.9 2542.165 2541.168 -2.4 174506.6* FOXO_KO.1 5.2428 0.4763 100 1901.872 1901.87 1.3 89295.8* FOXO_KO.1 3.792 0.2739 99.9 1901.869 1901.87 -0.4 223911.3* FOXO_KO.1 5.1966 0.4586 100 2020.968 2019.969 -2.4 81291.7* FOXO_KO.1 6.4415 0.4828 100 2614.158 2612.165 -5.5 117577.9

FOXO_KO.9 4.7074 0.3699 100 1750.661 1749.663 -3 176832.2* FOXO_KO.1 6.6119 0.4973 100 2248.943 2247.943 -1.2 143681.1* FOXO_KO.1 4.0405 0.3585 99.9 2248.942 2247.943 -1.7 321511.3* FOXO_KO.3 3.5195 0.2309 99.8 1443.641 1443.642 -0.8 62961.4* FOXO_KO.2 4.6779 0.4416 100 3511.674 3511.672 0.7 113620.9* FOXO_KO.2 3.827 0.3949 100 1956.962 1955.96 -0.3 117026.4* FOXO_KO.2 4.5989 0.4804 100 2459.181 2458.181 -1.1 74995.4* FOXO_KO.3 5.0735 0.4849 100 1568.745 1567.743 -0.9 190256.7* FOXO_KO.1 4.3993 0.4367 100 1556.656 1554.653 -2.3 386207.6* FOXO_KO.1 2.9818 0.2782 99.7 1554.652 1554.653 -0.7 221135.4* FOXO_KO.1 3.1586 0.4413 100 1639.938 1639.938 -0.1 183854.9* FOXO_KO.3 5.297 0.4829 100 1724.837 1724.835 1.3 203282.9* FOXO_KO_w 2.9665 0.4254 100 1138.497 1138.498 -0.5 91736.3* FOXO_KO.1 4.2505 0.3727 100 1881.924 1880.921 -0.4 103987.8* FOXO_KO.1 5.9888 0.5187 100 1927.799 1927.798 0.2 159735.4* FOXO_KO.1 4.8801 0.5814 100 1928.8 1927.798 -0.8 379437.4IPI:IPI00 13 36 36.50% 375 41737 5.5 U Tax_Id=10090 Gene_Symbol=Actb Actin, cytoplasmic 1 IPI:IPI00 13 36 36.50% 375 41793 5.5 U Tax_Id=10090 Gene_Symbol=Actg1 Actin, cytoplasmic 2

FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6

FOXO_KO.1 5.0386 0.3143 100 1955.065 1954.064 -1.3 111873.8FOXO_KO.2 5.4972 0.4231 100 3185.618 3183.614 -1 138736.3FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2FOXO_KO.8 3.4566 0.4039 100 1516.694 1516.703 -5.9 462543.8FOXO_KO.8 2.8206 0.2602 99.5 1516.696 1516.703 -4.3 692797

contamina 22 36 36.30% 622 61987 5.2 U no description* FOXO_KO.3 3.4305 0.471 100 1235.528 1235.529 -0.9 67366.4* FOXO_KO.2 7.6794 0.4341 100 2378.194 2377.188 0.8 68575.8* FOXO_KO.2 4.5869 0.4191 100 2378.192 2377.188 0.1 214278.6* FOXO_KO.3 6.6181 0.5033 100 3326.63 3325.622 1.2 71870.2* FOXO_KO.1 5.52 0.4471 100 1586.764 1586.766 -0.8 301068* FOXO_KO.2 3.4778 0.3078 99.9 2537.202 2535.2 -1.8 188224.1* FOXO_KO.3 4.4187 0.4231 100 2904.4 2902.41 -6 32278* FOXO_KO.3 3.9131 0.3612 99.9 2903.408 2902.41 -1.8 583023.4* FOXO_KO.4 4.9538 0.3797 100 3945.957 3943.956 -1.5 20971.8* FOXO_KO.1 3.5656 0.3826 100 1315.682 1315.685 -2.5 226234.9* FOXO_KO.1 2.8767 0.1905 99.6 1060.562 1060.563 -1.3 390610.4* FOXO_KO.3 6.1757 0.4398 100 2301.127 2299.12 0.3 54203.3* FOXO_KO.2 3.0211 0.2922 99.7 1851.926 1851.927 -0.6 101446.3* FOXO_KO.3 5.0538 0.4067 100 4391.16 4389.155 -0.5 138455.2* FOXO_KO.2 6.9004 0.4449 100 3394.619 3392.609 1 117822* FOXO_KO.3 5.1191 0.3925 100 3266.526 3264.514 1.5 490645.9* FOXO_KO.2 6.7042 0.524 100 1837.966 1837.965 0.3 151781.4* FOXO_KO.2 4.0364 0.2377 99.9 1838.967 1837.965 -0.7 197681.1* FOXO_KO.2 5.5861 0.4424 100 2096.039 2095.038 -0.8 110232.9* FOXO_KO.2 6.6526 0.4188 100 2511.132 2510.132 -1.3 236207.5* FOXO_KO.2 5.9935 0.4092 100 2511.138 2510.132 1 262411* FOXO_KO.2 6.127 0.352 100 1792.729 1791.728 -1.3 54435.5IPI:IPI00 11 31 36.30% 295 32620 5.3 U Tax_Id=10090 Gene_Symbol=Actg1 Actin, gamma, cytoplasmic 1

FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.2 5.4972 0.4231 100 3185.618 3183.614 -1 138736.3FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2FOXO_KO.8 3.4566 0.4039 100 1516.694 1516.703 -5.9 462543.8FOXO_KO.8 2.8206 0.2602 99.5 1516.696 1516.703 -4.3 692797

IPI:IPI00 7 10 36.30% 135 15524 9.8 U Tax_Id=10090 Gene_Symbol=Rps17 40S ribosomal protein S17 IPI:IPI00 7 10 35.50% 138 15832 9.5 U Tax_Id=10090 Gene_Symbol=Gm12034 similar to ribosomal protein S17

IPI:IPI007 7 10 31.80% 154 17640 9.4 U Tax_Id=10090 Gene_Symbol=Gm12034 similar to ribosomal protein S17 FOXO_KO.3 6.2336 0.3711 100 2646.295 2645.294 -0.8 45481.7FOXO_KO.3 3.534 0.2719 99.7 2646.292 2645.294 -2.1 144506FOXO_KO.3 6.1533 0.392 100 3148.559 3146.556 -1.4 234945.6FOXO_KO.3 5.1968 0.4982 100 2491.181 2489.193 -7.5 20634.2FOXO_KO.3 4.0735 0.4218 100 2490.191 2489.193 -1.9 165634.7FOXO_KO.3 4.0552 0.3308 100 2991.463 2990.455 1.5 29259.8FOXO_KO.3 5.1918 0.4112 100 2490.222 2489.215 1.8 42436.1

contamina 21 38 36.10% 593 59519 5.2 U no description* FOXO_KO.1 6.0973 0.5659 100 1708.774 1707.772 -0.7 207493

FOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9FOXO_KO.1 4.4947 0.4664 100 1381.648 1381.648 0.2 1963621

* FOXO_KO.4 5.2435 0.4267 100 3053.634 3052.627 1.1 113594* FOXO_KO.3 7.9817 0.5063 100 2368.268 2367.263 1 117288.1* FOXO_KO.1 3.1157 0.2764 99.9 1234.679 1234.679 -0.1 198016.1* FOXO_KO.4 5.5847 0.474 100 2097.053 2096.047 1.3 89078.9

FOXO_KO.3 5.6327 0.5315 100 2874.398 2872.393 -0.6 22109.1FOXO_KO.3 4.7046 0.3619 99.9 2873.401 2872.393 1.6 70284.9

* FOXO_KO_w 3.7945 0.3662 100 1493.735 1493.734 0.2 155518.3* FOXO_KO_w 2.1674 0.3135 99.5 1494.735 1493.734 -1.6 78873.5* FOXO_KO.2 5.4326 0.4834 100 2584.208 2584.206 0.7 107333.7* FOXO_KO.1 3.0565 0.3181 99.9 1237.582 1237.585 -2.6 252645.4* FOXO_KO.1 5.9292 0.5419 100 2214.103 2212.098 -0.6 71133.9* FOXO_KO.1 3.6335 0.2125 99.5 2212.092 2212.098 -2.6 184433* FOXO_KO.2 5.6478 0.4598 100 1997.976 1996.971 0.8 1219086* FOXO_KO.2 3.2816 0.4067 99.9 1996.972 1996.971 0.6 98228.9* FOXO_KO.3 3.1296 0.2593 99.5 2982.507 2981.506 -0.7 106665.7

FOXO_KO.1 3.4083 0.4884 100 1390.68 1390.681 -0.7 150393.8* FOXO_KO.2 5.7832 0.4286 100 2082.966 2082.965 0.6 270486.4* FOXO_KO_w 3.9616 0.4376 100 1262.598 1262.597 0.6 33245.2IPI:IPI00 10 13 36.10% 465 54174 7.3 U Tax_Id=10090 Gene_Symbol=Stk38 Serine/threonine-protein kinase 38

FOXO_KO.3 4.5282 0.3322 100 2064.025 2063.019 1.1 135024FOXO_KO_w 3.2599 0.2929 99.9 1591.762 1591.763 -0.8 60121.5FOXO_KO.4 6.803 0.3729 100 3619.853 3617.849 -0.6 68778.7FOXO_KO.1 2.8553 0.3483 99.9 1370.752 1370.753 -0.6 215299.8

* FOXO_KO.3 3.912 0.2136 99.5 3014.429 3013.417 3 80369* FOXO_KO.3 4.3374 0.3362 99.9 2857.316 2857.315 0.3 80544.4* FOXO_KO.3 6.2707 0.4256 100 2771.383 2769.399 -8.4 139693.9* FOXO_KO.3 4.6887 0.4423 100 1776.853 1775.85 -0.3 228064.4* FOXO_KO.2 5.0557 0.3842 100 3616.647 3615.65 -1.7 62438.2* FOXO_KO.2 4.1429 0.3703 100 1827.867 1826.863 0.4 144894.9IPI:IPI00 5 7 36.00% 197 21560 4.3 U Tax_Id=10090 Gene_Symbol=Calm1;Calm3;Calm2 Putative uncharacterized protein IPI:IPI00 5 7 47.70% 149 16838 4.2 U Tax_Id=10090 Gene_Symbol=Calm1;Calm3;Calm2 Calmodulin

FOXO_KO.2 4.7118 0.3689 100 1846.9 1844.891 0.9 295499FOXO_KO.1 3.8534 0.195 99.5 1984.945 1983.944 -1 130037.3FOXO_KO.1 4.976 0.4717 100 1755.873 1754.871 -0.8 184818FOXO_KO.3 5.9563 0.1312 99.9 2491.067 2490.08 -6.6 40847.5FOXO_KO.3 5.5556 0.4434 100 2492.068 2490.08 -7.3 149998

IPI:IPI00 1 1 35.50% 76 8512 4.3 U Tax_Id=10090 Gene_Symbol=Rbbp7 Retinoblastoma binding protein 7 FOXO_KO.2 3.3899 0.2492 99.5 2847.341 2847.343 -0.6 84370.9

IPI:IPI00 11 12 35.00% 331 38092 5.8 U Tax_Id=10090 Gene_Symbol=Eif2s2 Eukaryotic translation initiation factor 2 subunit 2 FOXO_KO.1 4.9372 0.411 100 2639.218 2638.219 -1.5 104950.7FOXO_KO.2 5.3522 0.3006 100 2012.946 2012.956 -4.9 143168.5FOXO_KO.2 4.8696 0.4774 100 2012.954 2012.956 -1.2 198966FOXO_KO.3 5.7783 0.4732 100 1757.768 1756.766 -0.7 313725.2FOXO_KO.2 6.6678 0.3746 100 1863.982 1862.975 2.5 169119.4FOXO_KO.2 5.5167 0.2334 99.9 1862.972 1862.975 -1.2 209028.4FOXO_KO.3 4.9963 0.3625 100 1734.88 1734.88 0 189801.2FOXO_KO.3 3.1742 0.2604 99.7 1734.878 1734.88 -1.2 458949.7

* FOXO_KO.2 5.3269 0.2485 100 2430.104 2429.102 -0.8 58211* FOXO_KO.2 3.4876 0.2795 99.7 2430.107 2429.102 0.6 171522.9

FOXO_KO.2 4.7532 0.3263 99.9 4302.93 4302.932 -0.5 130198IPI:IPI00 2 9 34.80% 66 7594 11.2 U Tax_Id=10090 Gene_Symbol=Gcdh 8 kDa protein

FOXO_KO.3 5.6439 0.4828 100 2717.384 2716.383 -0.7 155100.1FOXO_KO.2 4.306 0.3521 100 1613.829 1613.827 1.1 247361.9

IPI:IPI00 4 7 34.50% 194 22127 10.1 U Tax_Id=10090 Gene_Symbol=Rps7 40S ribosomal protein S7 * FOXO_KO.3 5.1299 0.3916 100 3330.682 3330.677 1.5 181383.9* FOXO_KO.3 3.7402 0.2392 99.5 3332.662 3330.677 -6.6 136756.4

FOXO_KO.3 7.0584 0.5906 100 2368.281 2367.281 -1.1 140947.3FOXO_KO.3 2.7297 0.3174 99.8 1783.89 1783.89 -0.2 148761.4

IPI:IPI00 22 39 34.10% 490 54565 5.8 U Tax_Id=10090 Gene_Symbol=Krt8 Keratin, type II cytoskeletal 8 FOXO_KO.3 4.6683 0.5496 100 1847.806 1847.805 0.5 107672.2FOXO_KO.3 7.2824 0.5712 100 2035.062 2034.058 0.4 177045.2FOXO_KO.3 4.2492 0.4418 100 2035.073 2034.058 6.1 115152.5FOXO_KO.3 5.7888 0.4651 100 3324.697 3323.694 -0.1 133010.9FOXO_KO.3 6.2574 0.4042 100 3325.699 3323.694 -0.5 335599.8FOXO_KO.3 3.499 0.2971 99.9 1793.9 1792.879 9.8 162155.7FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715FOXO_KO.2 3.8624 0.4035 100 1352.677 1352.677 -0.1 244658.3FOXO_KO.1 3.7357 0.2457 99.9 1480.77 1480.772 -1 323037.5FOXO_KO.1 3.9141 0.4453 100 1926.928 1925.927 -1.4 285097.9FOXO_KO.1 2.3294 0.4073 100 1084.461 1084.462 -0.8 62485.5FOXO_KO.1 2.6716 0.33 99.9 1084.462 1084.462 0.1 260885.7FOXO_KO.1 5.2435 0.4477 100 1798.834 1797.832 -0.8 319330.1FOXO_KO.3 4.3494 0.4666 100 1419.747 1419.748 -0.7 725049.9FOXO_KO.2 5.1816 0.4705 100 2109.016 2109.013 1.5 81687.8

* FOXO_KO.2 4.0857 0.4469 100 1318.666 1318.667 -0.9 225259.5FOXO_KO_w 2.3764 0.3478 100 1079.513 1079.512 1.5 20194.2FOXO_KO.2 4.654 0.379 100 1345.679 1344.675 -0.1 336361.8

* FOXO_KO.3 5.2191 0.4447 100 2517.257 2517.261 -1.8 315659.2* FOXO_KO.5 5.1057 0.401 100 3612.88 3611.87 2 77421.8* FOXO_KO_w 2.7911 0.3933 100 1150.606 1149.6 2.5 87088IPI:IPI00 12 35 34.00% 374 41800 6.3 U Tax_Id=10090 Gene_Symbol=Actb Putative uncharacterized protein

FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6FOXO_KO.1 5.0386 0.3143 100 1955.065 1954.064 -1.3 111873.8

FOXO_KO.2 5.4972 0.4231 100 3185.618 3183.614 -1 138736.3FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2FOXO_KO.8 3.4566 0.4039 100 1516.694 1516.703 -5.9 462543.8FOXO_KO.8 2.8206 0.2602 99.5 1516.696 1516.703 -4.3 692797

IPI:IPI00 12 32 33.30% 375 41738 5.4 U Tax_Id=10090 Gene_Symbol=Actg1 Putative uncharacterized protein FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.1 5.0386 0.3143 100 1955.065 1954.064 -1.3 111873.8FOXO_KO.2 5.4972 0.4231 100 3185.618 3183.614 -1 138736.3FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2FOXO_KO.8 3.4566 0.4039 100 1516.694 1516.703 -5.9 462543.8FOXO_KO.8 2.8206 0.2602 99.5 1516.696 1516.703 -4.3 692797

IPI:IPI00 3 6 33.10% 121 13539 6.4 U Tax_Id=10090 Gene_Symbol=Actb Beta-actin (Fragment) FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6FOXO_KO.1 5.0386 0.3143 100 1955.065 1954.064 -1.3 111873.8

IPI:IPI00 6 11 32.80% 317 34216 6.2 U Tax_Id=10090 Gene_Symbol=Rplp0 60S acidic ribosomal protein P0 FOXO_KO.2 4.6822 0.2805 100 1660.856 1660.857 -0.7 159848.7FOXO_KO.1 3.8377 0.3264 100 2180.099 2180.102 -1.3 54730.3FOXO_KO.4 6.4739 0.4647 100 3504.777 3503.781 -1.9 39109

* FOXO_KO.3 5.4239 0.5574 100 1941.026 1940.026 -1.9 125287.7FOXO_KO.2 6.0549 0.5342 100 2235.897 2234.892 0.6 76151.1FOXO_KO.3 4.3226 0.4589 100 2395.828 2394.824 0 70870

IPI:IPI00 3 4 32.80% 128 13553 10.6 U Tax_Id=10090 Gene_Symbol=H2afz Histone H2A.Z IPI:IPI00 3 4 32.80% 128 13509 10.6 U Tax_Id=10090 Gene_Symbol=H2afv Histone H2A.V IPI:IPI00 3 4 32.60% 129 13608 10.6 U Tax_Id=10090 Gene_Symbol=H2afv 14 kDa protein

FOXO_KO.6 5.4505 0.5213 100 2896.539 2895.535 0.2 62993FOXO_KO.6 5.9102 0.4682 100 3253.749 3251.741 0.3 76701.7FOXO_KO.1 2.4789 0.3595 99.9 1118.558 1118.558 0.2 228206.7

IPI:IPI00 2 4 32.20% 121 13584 4.8 U Tax_Id=10090 Gene_Symbol=Rpa3 Replication protein A 14 kDa subunit * FOXO_KO.4 5.8233 0.4161 100 2472.263 2471.259 0.3 56025.7* FOXO_KO.2 5.5547 0.3662 100 1956.94 1955.934 1.3 133151.1IPI:IPI00 1 1 32.00% 97 10885 5.9 U Tax_Id=10090 Gene_Symbol=Eif4a2 11 kDa protein IPI:IPI00 1 1 32.30% 96 10798 5.9 U Tax_Id=10090 Gene_Symbol=Eif4a2 11 kDa protein

FOXO_KO.4 5.363 0.5407 100 3475.493 3473.49 -0.8 56742.1IPI:IPI00 4 5 32.00% 97 10766 4.7 U Tax_Id=10090 Gene_Symbol=Hnrnpk Putative uncharacterized protein IPI:IPI00 4 5 7.10% 439 48467 6.3 U Tax_Id=10090 Gene_Symbol=- 48 kDa protein

FOXO_KO.9 5.3147 0.4099 100 1579.703 1579.706 -1.8 225521.2FOXO_KO.8 4.7697 0.4788 100 1735.801 1735.807 -3.4 139915FOXO_KO.8 4.1325 0.2851 99.9 1735.801 1735.807 -3.4 1996603FOXO_KO.1 4.9431 0.4986 100 1781.802 1780.798 0 325850.2

IPI:IPI00 3 5 31.60% 136 15388 11.3 U Tax_Id=10090 Gene_Symbol=Hist2h3c1;Hist1h3e;Hist1h3f;Hist2h3c2;Hist2h3b;Hist1h3b;Hist1h3d;Hist1h3c Histone H3.2 IPI:IPI00 3 5 23.80% 181 20247 11.4 U Tax_Id=10090 Gene_Symbol=Hist2h3c1;Hist1h3e;Hist1h3f;Hist2h3c2;Hist2h3b;Hist1h3b;Hist1h3d;Hist1h3c histone cluster 2, H3c1

FOXO_KO.1 3.2285 0.3275 99.9 1336.694 1335.69 0.4 280263.7FOXO_KO.5 6.8578 0.5371 100 3515.713 3513.703 0.9 73307FOXO_KO.5 3.8597 0.3119 99.9 3514.713 3513.703 1.8 52849.5

IPI:IPI005 2 3 31.60% 136 15324 11.3 U Tax_Id=10090 Gene_Symbol=Gm6421 hypothetical protein isoform 1 IPI:IPI00 2 3 36.10% 119 13322 11 U Tax_Id=10090 Gene_Symbol=- 13 kDa protein IPI:IPI00 2 3 31.60% 136 15328 11.3 U Tax_Id=10090 Gene_Symbol=LOC100045490;H3f3a;H3f3b Histone H3.3 IPI:IPI007 2 3 31.60% 136 15312 11.3 U Tax_Id=10090 Gene_Symbol=- hypothetical protein isoform 1 IPI:IPI006 2 3 31.60% 136 15204 10.8 U Tax_Id=10090 Gene_Symbol=Gm10257 hypothetical protein isoform 1

FOXO_KO.1 3.2285 0.3275 99.9 1336.694 1335.69 0.4 280263.7FOXO_KO.4 6.4687 0.4819 100 3439.713 3437.705 0.5 53406.3

IPI:IPI00 2 2 31.50% 127 14246 8.5 U Tax_Id=10090 Gene_Symbol=Fabp1 Fatty acid-binding protein, liver * FOXO_KO.2 5.8887 0.5025 100 2116.907 2116.905 1 74573.6* FOXO_KO.3 5.9932 0.5209 100 2387.17 2385.185 -9 101097.2IPI:IPI00 1 1 31.20% 109 12444 7.2 U Tax_Id=10090 Gene_Symbol=Glul 12 kDa protein

FOXO_KO.3 3.7369 0.252 99.7 3968.711 3966.704 -0.1 29026.9IPI:IPI002 12 15 31.00% 248 29021 4.8 U Tax_Id=10090 Gene_Symbol=Tpm3 Isoform 2 of Tropomyosin alpha-3 chain IPI:IPI00 12 15 31.00% 248 28734 4.7 U Tax_Id=10090 Gene_Symbol=Tpm3 29 kDa protein IPI:IPI00 12 15 31.20% 247 28723 4.8 U Tax_Id=10090 Gene_Symbol=Tpm3 29 kDa protein IPI:IPI00 12 15 31.00% 248 28992 4.8 U Tax_Id=10090 Gene_Symbol=- 29 kDa protein IPI:IPI00 12 15 31.00% 248 28896 4.8 U Tax_Id=10090 Gene_Symbol=Tpm3 Putative uncharacterized protein

FOXO_KO.9 6.3079 0.5295 100 1770.895 1770.898 -1.8 259588.4FOXO_KO.1 4.9157 0.3455 99.9 2127.08 2127.079 0.6 243835.8FOXO_KO.1 4.8163 0.4034 100 1642.8 1642.803 -1.7 224241.3FOXO_KO.1 5.289 0.3362 100 1999.982 1998.984 -2.5 130597.8FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9FOXO_KO.1 5.8194 0.4341 100 1945.03 1945.031 -0.4 187997.5FOXO_KO.1 3.5628 0.2809 99.9 1284.75 1284.752 -1.6 249361.9FOXO_KO.1 4.4374 0.4257 100 1799.984 1799.986 -1.4 74303.1

IPI:IPI004 4 9 31.00% 158 17276 5 U Tax_Id=10090 Gene_Symbol=LOC633387 similar to Npm1 protein FOXO_KO.1 7.2234 0.4881 100 2575.186 2573.201 -8.8 104707.5FOXO_KO.7 3.2443 0.399 99.9 1568.728 1568.73 -1.3 539482.4FOXO_KO.3 4.8739 0.3409 99.9 2930.463 2929.461 -0.6 82699.4FOXO_KO.2 6.3012 0.4 100 2145.014 2145.017 -1.5 219432.7

IPI:IPI00 3 4 31.00% 129 13988 10.9 U Tax_Id=10090 Gene_Symbol=Hist2h2ab;Hist2h2ac Histone H2A type 2-C IPI:IPI00 3 4 30.80% 130 14095 10.9 U Tax_Id=10090 Gene_Symbol=Hist2h2aa1;Hist2h2aa2 Histone H2A type 2-A

FOXO_KO.6 5.0228 0.4946 100 2934.548 2933.544 0.1 23636.3FOXO_KO.6 4.4444 0.5543 100 2933.546 2933.544 0.7 59417.4FOXO_KO.1 3.5161 0.2557 99.9 1272.678 1272.679 -1.1 375019.8

IPI:IPI00 6 6 30.80% 156 17951 9.6 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc;Gm6111 ribosomal protein S27a FOXO_KO.2 5.5921 0.3943 100 1788.93 1787.927 -0.2 625230.5FOXO_KO.1 6.0569 0.5383 100 2158.843 2157.842 -1.3 131944.5FOXO_KO.1 4.6764 0.452 100 1869.773 1868.769 0.1 73724.9FOXO_KO.1 2.7883 0.2672 99.5 1869.773 1868.769 0.4 848001.3FOXO_KO.1 4.7916 0.3189 100 1735.729 1734.728 -1.4 210784.1FOXO_KO.1 3.3115 0.2928 99.9 1734.727 1734.728 -0.6 447011.1

IPI:IPI00 3 3 30.80% 104 11438 11.4 U Tax_Id=10090 Gene_Symbol=- 11 kDa protein IPI:IPI00 3 3 30.80% 104 11481 11.4 U Tax_Id=10090 Gene_Symbol=- 11 kDa protein IPI:IPI00 3 3 30.80% 104 11482 11.2 U Tax_Id=10090 Gene_Symbol=- 11 kDa protein IPI:IPI00 3 3 30.50% 105 11614 11.4 U Tax_Id=10090 Gene_Symbol=- 12 kDa protein IPI:IPI00 3 3 30.50% 105 11632 11.2 U Tax_Id=10090 Gene_Symbol=- 12 kDa protein IPI:IPI00 3 3 30.50% 105 11628 11.4 U Tax_Id=10090 Gene_Symbol=- 12 kDa protein IPI:IPI006 3 3 20.30% 158 17239 10.6 U Tax_Id=10090 Gene_Symbol=LOC674678 similar to histone H4 IPI:IPI00 3 3 30.80% 104 11466 11.4 U Tax_Id=10090 Gene_Symbol=- 11 kDa protein IPI:IPI00 3 3 30.80% 104 11468 11.4 U Tax_Id=10090 Gene_Symbol=- 11 kDa protein IPI:IPI00 3 3 31.10% 103 11367 11.4 U Tax_Id=10090 Gene_Symbol=Hist1h4c;Hist1h4m;Hist1h4j;Hist1h4i;Gm11275;Hist1h4a;Hist1h4f;Hist2h4;Hist1h4h;Hist4h4;Hist1h4k;4930558J22Rik;Hist1h4d;Hist1h4b Histone H4

FOXO_KO.1 3.7186 0.3885 100 1325.754 1325.754 0 406797.4FOXO_KO.1 3.2304 0.2571 99.9 1180.618 1180.621 -2.2 489715.3FOXO_KO.3 3.1272 0.3584 100 1136.55 1134.543 0.6 106280.2

IPI:IPI008 1 1 30.80% 52 6192 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 Tpm1 protein FOXO_KO.1 3.8103 0.3227 99.9 1960.006 1960.006 0.1 332255.9

IPI:IPI00 3 3 30.60% 108 12496 9.4 U Tax_Id=10090 Gene_Symbol=Atp5j;LOC674583 ATP synthase-coupling factor 6, mitochondrial FOXO_KO.1 4.2758 0.4415 100 2044.952 2044.957 -2.3 70766.7

* FOXO_KO.1 3.7892 0.3429 100 1664.814 1664.817 -1.8 272852.5* FOXO_KO.1 3.4882 0.3215 99.9 1665.818 1664.817 -1.1 366506.4IPI:IPI001 14 17 30.30% 284 32681 4.7 U Tax_Id=10090 Gene_Symbol=Tpm1 Isoform 1 of Tropomyosin alpha-1 chain IPI:IPI00 14 17 26.40% 326 37413 4.7 U Tax_Id=10090 Gene_Symbol=Tpm1 37 kDa protein IPI:IPI00 14 17 30.00% 287 32900 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 33 kDa protein IPI:IPI00 14 17 30.60% 281 32495 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 9 IPI:IPI00 14 17 30.30% 284 32699 4.7 U Tax_Id=10090 Gene_Symbol=Tpm1 Putative uncharacterized protein IPI:IPI002 14 17 30.30% 284 32709 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 Isoform 2 of Tropomyosin alpha-1 chain

FOXO_KO.1 5.2443 0.403 100 2410.194 2410.198 -1.7 225002.4FOXO_KO.1 4.4004 0.3978 100 1597.758 1597.759 -0.8 184975.1FOXO_KO.1 5.3613 0.4842 100 2169.019 2169.019 0 50497.7FOXO_KO.3 5.3341 0.452 100 2853.407 2852.405 -0.3 129960.5FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9FOXO_KO.1 3.8103 0.3227 99.9 1960.006 1960.006 0.1 332255.9FOXO_KO.1 4.0147 0.3765 100 1315.767 1314.763 0.3 257598FOXO_KO.1 4.389 0.2889 100 1800.986 1799.986 -2.2 139234.9FOXO_KO.1 3.8697 0.3464 99.9 1799.984 1799.986 -1.2 369849FOXO_KO.1 3.5517 0.2115 99.8 1673.895 1671.891 -1.8 211568.5

IPI:IPI00 2 2 30.30% 155 17552 9.7 U Tax_Id=10090 Gene_Symbol=Mgst1 Microsomal glutathione S-transferase 1 IPI:IPI00 2 2 20.50% 229 25793 9.9 U Tax_Id=10090 Gene_Symbol=Mgst1 26 kDa protein

FOXO_KO.1 3.573 0.4441 100 1411.632 1411.631 0.3 207628.7FOXO_KO.5 5.6961 0.4764 100 3725.971 3723.957 2 32870.2

IPI:IPI00 12 14 30.20% 285 33281 4.8 U Tax_Id=10090 Gene_Symbol=Tpm3 Tropomyosin 3, gamma IPI:IPI002 12 14 30.30% 284 32863 4.7 U Tax_Id=10090 Gene_Symbol=Tpm3 Isoform 1 of Tropomyosin alpha-3 chain

FOXO_KO.1 5.2443 0.403 100 2410.194 2410.198 -1.7 225002.4FOXO_KO.1 4.4004 0.3978 100 1597.758 1597.759 -0.8 184975.1FOXO_KO.1 5.3613 0.4842 100 2169.019 2169.019 0 50497.7FOXO_KO.3 5.3341 0.452 100 2853.407 2852.405 -0.3 129960.5FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9FOXO_KO.1 5.8194 0.4341 100 1945.03 1945.031 -0.4 187997.5FOXO_KO.1 3.5628 0.2809 99.9 1284.75 1284.752 -1.6 249361.9FOXO_KO.1 4.4374 0.4257 100 1799.984 1799.986 -1.4 74303.1

IPI:IPI00 13 18 29.80% 732 83057 5.2 U Tax_Id=10090 Gene_Symbol=Xrcc5 ATP-dependent DNA helicase 2 subunit 2 * FOXO_KO.3 4.7996 0.4443 100 1869.942 1869.942 0.2 104165.6* FOXO_KO.3 3.9681 0.333 99.9 1870.945 1869.942 0.1 174763.5* FOXO_KO.1 4.3235 0.2607 99.9 2594.265 2593.264 -1.1 179235.4* FOXO_KO.4 4.3998 0.4674 100 2490.203 2489.175 9.7 16295.8* FOXO_KO.1 3.9443 0.3454 100 2880.252 2879.252 -1.1 25903.8* FOXO_KO.5 6.4346 0.5076 100 2723.418 2722.408 2.5 21061.7* FOXO_KO.5 4.7067 0.4592 100 2723.416 2722.408 1.5 33645.1* FOXO_KO.4 4.7004 0.4815 100 2262.064 2261.062 -0.5 117600.7* FOXO_KO.2 6.3056 0.5485 100 1893.921 1892.912 2.7 94684.3* FOXO_KO.2 3.2458 0.2534 99.7 1893.914 1892.912 -0.7 195461.8* FOXO_KO.1 7.1685 0.5039 100 2199.013 2198.011 -0.6 123254.6* FOXO_KO.5 4.4206 0.3597 99.9 3419.701 3417.692 0.5 90787.2* FOXO_KO.3 6.0335 0.4729 100 2478.123 2477.124 -1.6 30468.1IPI:IPI00 19 84 29.30% 646 70871 5.5 U Tax_Id=10090 Gene_Symbol=Hspa8 Heat shock cognate 71 kDa protein IPI:IPI00 19 84 30.10% 627 68779 5.5 U Tax_Id=10090 Gene_Symbol=Hspa8 Hspa8 protein

FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.1 5.2545 0.4539 100 1650.796 1649.795 -1.8 214685.6FOXO_KO.1 3.1871 0.3056 99.9 1410.667 1410.668 -1 235341.9FOXO_KO.2 4.0681 0.4993 100 1618.793 1616.788 -0.8 225950.2FOXO_KO.1 3.2851 0.3098 99.9 1252.66 1252.661 -0.5 194761.1FOXO_KO.2 3.4794 0.3266 100 1480.751 1480.754 -2.5 196915.1FOXO_KO.2 3.0387 0.2225 99.5 1480.755 1480.754 0.5 102785.9FOXO_KO.2 3.1533 0.3932 100 1253.616 1253.616 0.2 319502.1FOXO_KO.3 7.1018 0.6143 100 2261.15 2260.146 0.7 102609.9FOXO_KO.3 3.9984 0.4844 100 2261.152 2260.146 1.4 102527.8FOXO_KO.2 4.6041 0.4777 100 2775.328 2774.327 -0.9 24134.5FOXO_KO.6 4.375 0.4398 100 3773.936 3772.92 3.4 19698.3FOXO_KO.6 6.5954 0.4503 100 2516.306 2514.309 -3.8 18120.2FOXO_KO.2 4.6094 0.3004 99.9 3974.966 3972.965 -1.3 87844.9FOXO_KO.2 3.7135 0.2595 99.9 1277.62 1277.619 0.1 184476FOXO_KO.2 7.4347 0.3569 100 3005.415 3004.41 0.3 243308.8

FOXO_KO.1 5.5673 0.4878 100 1745.809 1745.809 -0.1 36310.4FOXO_KO.8 6.496 0.3136 100 2246.069 2245.073 -3.1 79248.9FOXO_KO.8 4.4007 0.3547 99.9 2246.063 2245.073 -6 274205.8

IPI:IPI00 1 2 29.30% 58 6881 4.8 U Tax_Id=10090 Gene_Symbol=Sgpl1 7 kDa protein IPI:IPI00 1 2 8.50% 199 22977 8.8 U Tax_Id=10090 Gene_Symbol=Sgpl1 23 kDa protein IPI:IPI00 1 2 16.30% 104 12427 9.7 U Tax_Id=10090 Gene_Symbol=Sgpl1 12 kDa protein

FOXO_KO.3 4.3065 0.3153 99.9 2077.068 2075.058 1.6 343942.8IPI:IPI00 4 6 29.20% 212 23730 8.9 U Tax_Id=10090 Gene_Symbol=Bhmt Putative uncharacterized protein

FOXO_KO.1 5.8809 0.5255 100 1817.903 1816.898 1 193570.5FOXO_KO.2 5.8761 0.5324 100 2410.129 2408.119 1.6 86062.1FOXO_KO.2 6.5921 0.5558 100 2453.169 2452.166 -0.3 51264.6FOXO_KO.2 5.2472 0.353 99.9 2453.169 2452.166 -0.3 158392.4

IPI:IPI00 10 33 29.00% 393 43601 5.2 U Tax_Id=10090 Gene_Symbol=Actg1 Gamma actin-like protein FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6FOXO_KO.1 5.0386 0.3143 100 1955.065 1954.064 -1.3 111873.8FOXO_KO.2 5.4972 0.4231 100 3185.618 3183.614 -1 138736.3FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2

IPI:IPI00 3 6 28.60% 241 26523 4.1 U Tax_Id=10090 Gene_Symbol=Clns1a Chloride channel, nucleotide-sensitive, 1A, isoform CRA_b FOXO_KO.1 3.0422 0.3218 99.9 1989.965 1988.954 4.2 97306.1

* FOXO_KO.2 5.5417 0.5062 100 3204.309 3202.311 -2.7 131048.4FOXO_KO.2 4.2776 0.5161 100 2770.148 2769.147 -0.6 41642.5

IPI:IPI00 9 9 28.40% 331 38120 5.9 U Tax_Id=10090 Gene_Symbol=Gm9892 similar to Eif2s2 protein FOXO_KO.1 4.9372 0.411 100 2639.218 2638.219 -1.5 104950.7FOXO_KO.2 5.3522 0.3006 100 2012.946 2012.956 -4.9 143168.5FOXO_KO.2 4.8696 0.4774 100 2012.954 2012.956 -1.2 198966FOXO_KO.3 5.7783 0.4732 100 1757.768 1756.766 -0.7 313725.2FOXO_KO.2 6.6678 0.3746 100 1863.982 1862.975 2.5 169119.4FOXO_KO.2 5.5167 0.2334 99.9 1862.972 1862.975 -1.2 209028.4FOXO_KO.3 4.9963 0.3625 100 1734.88 1734.88 0 189801.2FOXO_KO.3 3.1742 0.2604 99.7 1734.878 1734.88 -1.2 458949.7FOXO_KO.2 4.7532 0.3263 99.9 4302.93 4302.932 -0.5 130198

IPI:IPI00 7 14 28.30% 152 17719 11 U Tax_Id=10090 Gene_Symbol=Rps18 40S ribosomal protein S18 IPI:IPI00 7 14 28.30% 152 17691 10.9 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein IPI:IPI00 7 14 28.30% 152 17672 10.7 U Tax_Id=10090 Gene_Symbol=Gm10260 similar to ribosomal protein IPI:IPI00 7 14 28.30% 152 17749 10.9 U Tax_Id=10090 Gene_Symbol=Gm11361;LOC100047329 MCG116671

FOXO_KO_w 3.9668 0.4067 100 1403.675 1403.676 -1 52628.2FOXO_KO_w 3.0781 0.3279 99.9 1403.672 1403.676 -2.9 77587.5FOXO_KO.3 4.3234 0.2871 99.9 2458.261 2456.256 -0.7 204156.6FOXO_KO.2 3.8452 0.2817 99.9 2534.3 2533.301 -1.4 177906.9FOXO_KO.1 3.6644 0.3632 100 1321.674 1321.675 -0.6 167963.7FOXO_KO.2 4.2011 0.3516 100 2235.142 2233.157 -9.6 156217.9FOXO_KO.2 3.6373 0.3544 99.9 2234.162 2233.157 0.9 313309.9

IPI:IPI00 12 16 28.20% 284 32777 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 33 kDa protein IPI:IPI00 12 16 32.30% 248 28696 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 7 IPI:IPI00 12 16 32.70% 245 28483 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 28 kDa protein IPI:IPI00 12 16 32.30% 248 28668 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 29 kDa protein

FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9FOXO_KO.1 3.8103 0.3227 99.9 1960.006 1960.006 0.1 332255.9FOXO_KO.1 4.0147 0.3765 100 1315.767 1314.763 0.3 257598FOXO_KO.1 4.389 0.2889 100 1800.986 1799.986 -2.2 139234.9FOXO_KO.1 3.8697 0.3464 99.9 1799.984 1799.986 -1.2 369849FOXO_KO.1 3.5517 0.2115 99.8 1673.895 1671.891 -1.8 211568.5FOXO_KO.1 6.1221 0.473 100 2520.204 2518.202 -1.9 23991.6FOXO_KO.1 5.2574 0.367 100 2519.202 2518.202 -1.3 203517.6

IPI:IPI00 5 8 28.00% 321 34884 6.4 U Tax_Id=10090 Gene_Symbol=Pura;LOC100045958 Transcriptional activator protein Pur-alpha IPI:IPI00 5 8 29.70% 303 33476 6.3 U Tax_Id=10090 Gene_Symbol=LOC100045958 similar to hCG45299 isoform 3 IPI:IPI00 5 8 30.50% 295 33018 6.6 U Tax_Id=10090 Gene_Symbol=LOC100045958 similar to hCG45299 isoform 2

FOXO_KO.3 6.1125 0.3171 99.9 3428.645 3426.635 1 56352.4FOXO_KO.2 4.7551 0.3671 100 2734.309 2733.299 2.3 30216FOXO_KO.2 4.8737 0.39 100 2891.4 2889.4 -2.2 35872.7FOXO_KO.2 5.7303 0.5194 100 2890.401 2889.4 -0.7 399723.2FOXO_KO.2 5.1777 0.4463 100 3927.777 3925.774 -0.9 35883.6

IPI:IPI00 4 8 28.00% 125 14463 10.5 U Tax_Id=10090 Gene_Symbol=Gm8759;Gm10191;Rpl31 60S ribosomal protein L31 IPI:IPI006 4 8 28.20% 124 14335 10.5 U Tax_Id=10090 Gene_Symbol=LOC638399 hypothetical protein isoform 1

FOXO_KO.2 4.5807 0.4446 100 2958.523 2957.525 -2 119338.6FOXO_KO.3 6.4022 0.512 100 2674.336 2673.329 1.4 32914.4FOXO_KO.3 3.7468 0.4091 99.9 2674.332 2673.329 -0.3 87960.9FOXO_KO.9 2.6796 0.4224 100 1145.542 1145.543 -1.3 72184.1

IPI:IPI00 10 15 27.90% 509 57059 4.9 U Tax_Id=10090 Gene_Symbol=P4hb Putative uncharacterized protein IPI:IPI001 10 15 27.90% 509 57144 4.9 U Tax_Id=10090 Gene_Symbol=P4hb Protein disulfide-isomerase

FOXO_KO.1 6.1151 0.4714 100 1782.839 1780.835 -1.2 323074.9FOXO_KO.1 3.6533 0.3649 99.9 1781.834 1780.835 -2.6 326804.6FOXO_KO.2 2.7109 0.4137 100 1202.603 1202.605 -1.4 146168.2FOXO_KO.4 5.3314 0.2829 99.9 2987.495 2985.494 -2 47895.9FOXO_KO.5 4.2835 0.3787 99.9 3818.868 3816.855 1.8 19997.6FOXO_KO_w 2.9682 0.2889 99.8 1410.68 1409.679 -1.9 254734.4FOXO_KO.2 4.5973 0.4226 100 1666.836 1666.832 2.2 184894.6FOXO_KO.9 4.3215 0.3876 100 1293.6 1293.599 0.5 309839FOXO_KO.2 3.4551 0.2641 99.6 3628.464 3626.46 -0.8 74954.1FOXO_KO.3 3.88 0.3146 99.9 4283.818 4281.815 -0.8 5939

IPI:IPI00 6 9 27.90% 308 33331 10.3 U Tax_Id=10090 Gene_Symbol=Csda DbpA murine homologue IPI:IPI00 6 9 28.80% 299 31822 10.3 U Tax_Id=10090 Gene_Symbol=Csda Csda protein IPI:IPI002 6 9 29.50% 292 30765 9.6 U Tax_Id=10090 Gene_Symbol=Csda Isoform 2 of DNA-binding protein A

FOXO_KO.2 6.2205 0.4505 100 1796.825 1795.823 -1 263572.8FOXO_KO.2 5.0578 0.4115 100 3561.68 3559.667 1.7 50205.9FOXO_KO.1 5.7631 0.4831 100 1782.86 1782.862 -0.8 114277.8

FOXO_KO.1 6.7074 0.5231 100 2338.125 2337.125 -1.4 120402.5FOXO_KO.8 4.5118 0.5386 100 2914.396 2913.42 -9.4 40163.2FOXO_KO.9 5.3901 0.4649 100 2662.247 2660.266 -9.7 194787.4

IPI:IPI00 6 8 27.90% 201 22282 7.2 U Tax_Id=10090 Gene_Symbol=Gpx1 Glutathione peroxidase 1 * FOXO_KO.1 3.0242 0.2071 99.7 1256.545 1256.546 -1.1 213875.3* FOXO_KO.2 4.0152 0.4437 100 1884.911 1883.906 0.9 103086.8* FOXO_KO.1 2.3076 0.3617 100 1136.535 1136.537 -1.5 111661.9* FOXO_KO.1 2.7006 0.2901 99.8 1136.539 1136.537 2 268505.3* FOXO_KO.3 3.3817 0.3468 99.9 2060.004 2060.003 0.5 83002.8* FOXO_KO.3 5.9285 0.4632 100 2062.012 2060.003 0.9 434518.1IPI:IPI00 7 7 27.90% 172 19895 4.8 U Tax_Id=10090 Gene_Symbol=2900073G15Rik myosin light chain, regulatory B-like IPI:IPI00 7 7 27.90% 172 19874 4.9 U Tax_Id=10090 Gene_Symbol=2900073G15Rik Putative uncharacterized protein

FOXO_KO.1 2.9561 0.3844 100 1237.56 1237.563 -2.5 232629.8FOXO_KO.2 5.9589 0.5379 100 2021.932 2021.931 0.5 133458.5FOXO_KO.2 3.955 0.4821 100 2021.931 2021.931 -0.1 280987.1FOXO_KO.2 3.2987 0.4178 99.9 2022.932 2021.931 -1 183959FOXO_KO.2 4.8978 0.2517 100 2433.131 2432.128 -0.2 94538.5FOXO_KO.2 3.8695 0.3953 99.9 2433.129 2432.128 -1.1 169231FOXO_KO.1 4.0631 0.3864 100 1415.632 1415.632 -0.3 300836.3

IPI:IPI00 6 25 27.90% 136 15209 4.6 U Tax_Id=10090 Gene_Symbol=Actb Cytoskeletal beta-actin (Fragment) FOXO_KO.9 2.8773 0.5604 100 1132.528 1132.527 0.5 228621.5FOXO_KO.4 4.4782 0.2856 99.9 3164.53 3163.517 2.9 87064.3FOXO_KO.3 6.0909 0.5136 100 2808.316 2807.311 0.6 19991.1FOXO_KO.3 4.0841 0.3687 99.9 2808.319 2807.311 1.6 93123.5FOXO_KO.3 7.681 0.5495 100 2552.18 2550.174 0 64964.1FOXO_KO.3 5.1871 0.499 100 2550.174 2550.174 -0.1 192111.6

IPI:IPI003 4 6 27.80% 151 16961 4.6 U Tax_Id=10090 Gene_Symbol=Myl6 Isoform Smooth muscle of Myosin light polypeptide 6 FOXO_KO.1 5.8376 0.4254 100 1788.836 1786.824 2.9 298172.6FOXO_KO.1 4.2331 0.3625 99.9 1786.821 1786.824 -2 3115178FOXO_KO.2 4.0296 0.4129 100 1544.687 1544.686 0.3 299451.2

* FOXO_KO.3 6.2246 0.0945 99.5 3154.379 3153.381 -1.5 80702IPI:IPI00 1 2 27.60% 58 6834 10.2 U Tax_Id=10090 Gene_Symbol=Rpl10a 7 kDa protein

FOXO_KO.3 3.4929 0.3214 99.9 1900.969 1899.967 -0.7 141350.8IPI:IPI00 3 4 27.50% 204 23310 5.3 U Tax_Id=10090 Gene_Symbol=Prmt5 Protein

FOXO_KO.5 3.7584 0.3508 99.9 3690.743 3689.757 -4.5 28983.7FOXO_KO.3 5.2445 0.4225 100 2856.479 2855.475 0 144385.9FOXO_KO.2 3.5974 0.2161 99.6 2198.147 2198.148 -0.7 145758.3

IPI:IPI006 5 10 27.40% 317 34216 6.2 U Tax_Id=10090 Gene_Symbol=Gm8730 similar to Acidic ribosomal phosphoprotein P0 FOXO_KO.2 4.6822 0.2805 100 1660.856 1660.857 -0.7 159848.7FOXO_KO.1 3.8377 0.3264 100 2180.099 2180.102 -1.3 54730.3FOXO_KO.4 6.4739 0.4647 100 3504.777 3503.781 -1.9 39109FOXO_KO.2 6.0549 0.5342 100 2235.897 2234.892 0.6 76151.1FOXO_KO.3 4.3226 0.4589 100 2395.828 2394.824 0 70870

IPI:IPI00 5 6 27.40% 106 12291 4.9 U Tax_Id=10090 Gene_Symbol=Tpm2 Tropomyosin 2 beta FOXO_KO.1 2.8718 0.294 99.8 1599.736 1599.738 -1.6 159082.8FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6

FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965IPI:IPI00 4 5 27.20% 268 30943 7.5 U Tax_Id=10090 Gene_Symbol=Stk38 Putative uncharacterized protein

FOXO_KO.3 4.5282 0.3322 100 2064.025 2063.019 1.1 135024FOXO_KO_w 3.2599 0.2929 99.9 1591.762 1591.763 -0.8 60121.5FOXO_KO.4 6.803 0.3729 100 3619.853 3617.849 -0.6 68778.7FOXO_KO.1 2.8553 0.3483 99.9 1370.752 1370.753 -0.6 215299.8

IPI:IPI00 1 1 27.20% 125 14141 5.3 U Tax_Id=10090 Gene_Symbol=Gm13072;Trmt112 tRNA methyltransferase 112 homolog IPI:IPI00 1 1 27.20% 125 14185 5.3 U Tax_Id=10090 Gene_Symbol=- hypothetical protein IPI:IPI00 1 1 31.50% 108 12208 7.7 U Tax_Id=10090 Gene_Symbol=Trmt112 MCG130245, isoform CRA_b

FOXO_KO.3 4.5499 0.3612 99.9 3842.891 3841.892 -1.1 14985.4IPI:IPI001 1 2 27.20% 92 10804 9.4 U Tax_Id=10090 Gene_Symbol=Snrpe Small nuclear ribonucleoprotein E * FOXO_KO.4 5.971 0.3844 100 2912.356 2910.354 -1.3 86810.8IPI:IPI00 5 9 27.00% 115 13313 7.2 U Tax_Id=10090 Gene_Symbol=LOC100044912 similar to 14-3-3 protein theta-subtype

FOXO_KO.9 3.6169 0.324 100 1268.555 1268.558 -1.7 750942.8FOXO_KO_w 4.3571 0.4352 100 1396.651 1396.653 -1.1 54880FOXO_KO.1 7.7977 0.5474 100 2158.047 2157.046 -0.9 118500.4FOXO_KO.1 5.437 0.4251 100 2286.144 2285.141 -0.1 198856.9FOXO_KO.1 5.7757 0.1958 100 2028.95 2028.951 -0.7 122135

IPI:IPI00 2 2 27.00% 89 10103 6.1 U Tax_Id=10090 Gene_Symbol=Banf1 Barrier-to-autointegration factor * FOXO_KO.3 6.0153 0.5458 100 2417.243 2416.243 -1.3 59070.6* FOXO_KO.3 3.7628 0.4219 99.9 2417.243 2416.243 -1.2 202449.9IPI:IPI00 1 1 27.00% 37 4485 8.5 U Tax_Id=10090 Gene_Symbol=Uqcrq 4 kDa protein

FOXO_KO.2 3.4482 0.3739 100 1209.556 1209.557 -0.4 28178IPI:IPI008 6 12 26.90% 145 17072 10.4 U Tax_Id=10090 Gene_Symbol=LOC100046223 similar to insulinoma protein (rig) isoform 1

FOXO_KO.5 4.1472 0.4202 99.9 3157.523 3155.518 -0.5 43512.8FOXO_KO.5 6.0963 0.5634 100 2275.066 2274.067 -2 41134.2FOXO_KO.5 6.0848 0.5359 100 2589.237 2588.237 -1.4 24386.2FOXO_KO.5 6.6786 0.4309 100 2590.241 2588.237 -1.3 65976.6FOXO_KO_w 4.0933 0.4277 100 1481.801 1481.803 -1.3 52404.4FOXO_KO.8 3.4335 0.3056 99.9 1353.704 1353.708 -3 284062

IPI:IPI00 57 92 26.70% 1960 226370 5.7 U Tax_Id=10090 Gene_Symbol=Myh9 Myosin-9 FOXO_KO.2 5.5851 0.4271 100 2288.117 2286.11 0.2 60350.5FOXO_KO.3 4.7338 0.4814 100 1728.86 1727.856 0.5 138900.4FOXO_KO.1 6.1563 0.4136 100 2300.998 2299.995 -0.2 59219.3FOXO_KO.1 3.8968 0.2869 99.9 2299.994 2299.995 -0.5 147665.5

* FOXO_KO.2 5.3823 0.4801 100 2126.018 2126.018 -0.1 79212.6FOXO_KO.1 3.5795 0.3309 100 1223.636 1223.638 -1.6 244010FOXO_KO.2 4.6915 0.3902 100 1769.814 1769.812 1.1 120547.4FOXO_KO.3 5.276 0.462 100 2503.206 2501.219 -7.8 58461.1FOXO_KO.1 5.1653 0.4103 100 1769.847 1769.849 -0.9 164171.1FOXO_KO.2 6.5668 0.5031 100 2462.156 2461.151 0.6 51749.1FOXO_KO.2 4.0384 0.3274 99.9 2462.156 2461.151 0.7 162920.1FOXO_KO.2 4.5224 0.3708 99.9 2334.061 2333.056 0.8 180765.8FOXO_KO.1 6.6611 0.5576 100 1892.874 1892.873 0.4 107355.6FOXO_KO.1 4.3193 0.284 99.9 1894.884 1892.873 2.1 309522.2FOXO_KO.1 5.6316 0.4712 100 1764.779 1764.778 0.6 157325.2

* FOXO_KO.3 4.9151 0.3784 100 2512.231 2511.228 -0.2 239605.1* FOXO_KO.1 4.866 0.4463 100 1669.758 1669.763 -2.5 191368.9

* FOXO_KO.1 5.3448 0.5521 100 1884.89 1884.89 0.5 118835.9* FOXO_KO.1 4.5067 0.524 100 1585.761 1585.764 -1.7 208309.1* FOXO_KO.1 3.4625 0.3847 99.9 1585.762 1585.764 -0.9 230593.9* FOXO_KO.3 5.4156 0.4815 100 2772.443 2771.442 -0.9 30117.6* FOXO_KO.3 5.8319 0.4902 100 2771.443 2771.442 0.4 137493.2* FOXO_KO.3 7.226 0.5353 100 2615.342 2615.341 0.2 112401.2* FOXO_KO.3 4.3893 0.2999 99.9 2616.346 2615.341 0.4 159593.3* FOXO_KO.4 7.5963 0.5062 100 2488.251 2487.246 0.6 74710.8* FOXO_KO.4 5.7446 0.3874 100 2488.252 2487.246 0.9 214671.4* FOXO_KO.3 6.4043 0.5261 100 2318.152 2317.152 -1.1 103480.4* FOXO_KO.3 3.311 0.2851 99.8 2047.974 2047.967 3.8 71845.4* FOXO_KO.5 5.868 0.4711 100 3018.485 3017.48 0.5 30677* FOXO_KO.5 3.2031 0.3637 99.9 3018.49 3017.48 2.1 48709.1* FOXO_KO.5 4.4562 0.4247 100 3018.486 3017.48 1.1 118335* FOXO_KO.1 5.3034 0.4747 100 2028.962 2028.966 -1.6 77705.7* FOXO_KO.1 3.5007 0.3236 99.9 2028.964 2028.966 -0.9 159070.1* FOXO_KO.2 3.7184 0.2641 99.9 1826.894 1825.893 -1.3 168282* FOXO_KO.1 6.9517 0.551 100 1982.993 1981.994 -1.9 158466.3* FOXO_KO.1 4.4664 0.2806 100 1729.87 1729.872 -0.8 98573.7* FOXO_KO.3 6.4758 0.4643 100 2494.175 2493.174 -1 199151.2* FOXO_KO.4 3.701 0.3094 99.9 2495.167 2493.174 -5.3 160057.7* FOXO_KO.3 3.2662 0.2492 99.5 2751.331 2749.327 -1.3 62107.9* FOXO_KO.1 6.0814 0.4729 100 1767.794 1766.794 -1.8 117742* FOXO_KO.1 4.2334 0.3941 100 1922.893 1922.895 -0.6 197563* FOXO_KO.1 5.6397 0.5341 100 1638.695 1638.699 -1.9 269992.6* FOXO_KO.3 7.3307 0.4863 100 1951.999 1949.993 -0.4 384554.3* FOXO_KO.1 5.1787 0.4135 100 1685.744 1684.74 0 258332.3

FOXO_KO.2 6.6273 0.4815 100 1962.925 1961.919 1.7 105101* FOXO_KO.4 4.2605 0.3744 100 1226.597 1226.601 -3.3 143537.6* FOXO_KO.3 3.4794 0.3261 99.9 2049.949 2048.963 -8.2 65718.1* FOXO_KO.1 3.9681 0.3494 100 2246.081 2245.08 -1.2 45400.8* FOXO_KO.1 5.7008 0.4978 100 2088.981 2088.979 0.7 85090.6* FOXO_KO.1 3.6039 0.4094 99.9 2089.983 2088.979 0.1 175007.2* FOXO_KO.1 3.0495 0.4125 100 1348.624 1348.623 0.7 169455.1* FOXO_KO.2 7.4063 0.4074 100 2474.177 2472.174 -1.3 29750.4* FOXO_KO.2 4.2345 0.3424 99.9 2473.177 2472.174 0.1 183930.5* FOXO_KO.2 4.7197 0.2729 99.9 2713.351 2713.353 -0.6 224774.6* FOXO_KO.1 5.2698 0.4202 100 1815.907 1815.908 -0.7 165168.6* FOXO_KO.2 4.3021 0.3339 100 1293.605 1293.607 -1.5 56281.7* FOXO_KO.1 4.0882 0.5094 100 1565.672 1565.675 -1.9 365140.5IPI:IPI00 6 10 26.40% 208 24205 10.3 U Tax_Id=10090 Gene_Symbol=Gm15501;Rps8 40S ribosomal protein S8 IPI:IPI00 6 10 27.10% 203 23532 10.3 U Tax_Id=10090 Gene_Symbol=- 24 kDa protein

FOXO_KO.2 4.9554 0.4491 100 1788.748 1787.748 -1.4 548899FOXO_KO.1 3.3225 0.2386 99.8 1316.686 1314.679 0.7 307943.8FOXO_KO.1 4.4379 0.4429 100 1507.782 1506.78 -1 275448.3FOXO_KO.2 3.1759 0.3679 100 951.4775 951.4782 -0.7 50659FOXO_KO.2 5.2134 0.452 100 1902.967 1901.964 -0.2 200691.8FOXO_KO.2 4.5106 0.417 100 1901.965 1901.964 0.1 261497

IPI:IPI00 23 44 26.30% 707 76723 4.8 U Tax_Id=10090 Gene_Symbol=Ncl Nucleolin * FOXO_KO.3 4.8715 0.3628 100 2289.147 2288.156 -5.2 70305.4* FOXO_KO.1 2.7037 0.2193 99.6 1000.542 1000.542 -0.2 349210.3* FOXO_KO.2 6.1481 0.47 100 1776.831 1776.833 -0.7 135353.3* FOXO_KO.2 3.211 0.266 99.7 1777.831 1776.833 -2.6 233666* FOXO_KO.3 6.9652 0.4461 100 2603.334 2602.329 0.7 142943.1* FOXO_KO.2 5.5882 0.5616 100 1650.742 1648.738 -1.6 513690.7* FOXO_KO.2 2.85 0.3893 99.9 1422.711 1422.711 0 201652.5* FOXO_KO.4 5.8495 0.4627 100 2643.27 2642.265 0.4 49604.2* FOXO_KO.4 4.8698 0.4408 100 2643.271 2642.265 0.9 99148.6* FOXO_KO.4 6.3261 0.576 100 2182.041 2181.038 -0.2 92501.3* FOXO_KO.2 3.1377 0.3785 100 1238.571 1238.572 -1.1 363936.1* FOXO_KO.1 4.1953 0.3627 99.9 2286.151 2284.134 4.4 186577.7* FOXO_KO.3 5.9584 0.5299 100 2502.304 2501.302 -0.6 66564.9* FOXO_KO.2 1.9906 0.3556 99.8 1123.555 1123.552 2.7 127266* FOXO_KO.3 5.0443 0.4671 100 1594.739 1594.742 -2.1 305987.9* FOXO_KO.9 3.5488 0.3867 100 1322.63 1322.632 -1.9 308671.4* FOXO_KO.2 6.4706 0.5215 100 2215.042 2214.041 -1 142689.3* FOXO_KO.2 3.4735 0.5042 100 2214.039 2214.041 -1 362597.4* FOXO_KO.2 3.1145 0.4532 100 1561.682 1561.681 0.9 23932.6* FOXO_KO.2 4.9201 0.4555 100 1562.685 1561.681 0.9 386393.4* FOXO_KO.2 6.1419 0.5049 100 2120.981 2120.981 0.1 142211.1* FOXO_KO.1 5.99 0.4213 100 2348.127 2346.128 -3.2 75867.3* FOXO_KO.1 3.1179 0.2487 99.5 2347.131 2346.128 -0.4 286924.8IPI:IPI00 12 83 26.30% 655 72422 5.2 U Tax_Id=10090 Gene_Symbol=Hspa5 78 kDa glucose-regulated protein contamina 12 83 26.30% 654 72347 5.2 U owl|P06761| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN... contamin 12 83 26.30% 655 72421 5.2 U owl|P20029| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN...

FOXO_KO.2 5.7379 0.4723 100 3076.489 3074.487 -1.5 93245.3FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.1 3.1757 0.3987 100 1566.778 1566.78 -0.9 273199.2FOXO_KO.1 5.3256 0.3394 100 1677.808 1677.808 -0.1 160962.8FOXO_KO.3 6.8992 0.5651 100 2150.004 2148.997 1.7 2067927FOXO_KO.2 3.8378 0.3699 100 1512.751 1512.752 -0.4 150874.8FOXO_KO.2 6.5779 0.3968 100 2489.321 2488.314 1.5 55541FOXO_KO.2 3.4612 0.3777 99.9 1974.908 1974.908 0.1 285365.9FOXO_KO.2 8.4716 0.5582 100 2175.044 2174.04 0.3 208279.7FOXO_KO.2 3.9334 0.3146 99.9 2174.036 2174.04 -1.7 739911FOXO_KO.2 3.1931 0.3072 99.9 1397.789 1397.789 -0.1 165801.8FOXO_KO.1 7.2547 0.556 100 2179.977 2177.972 -0.6 130672.3

IPI:IPI00 4 4 26.10% 161 18749 5.7 U Tax_Id=10090 Gene_Symbol=Atp5h ATP synthase subunit d, mitochondrial IPI:IPI00 4 4 26.20% 160 18621 5.4 U Tax_Id=10090 Gene_Symbol=LOC100044492;Gm10250 hypothetical protein

FOXO_KO.1 4.5086 0.1686 99.8 2446.243 2445.24 0 39593.9FOXO_KO.1 4.2027 0.3882 99.9 2445.238 2445.24 -0.5 219119.9FOXO_KO.9 4.2715 0.374 100 1667.818 1666.817 -1.4 470893.4FOXO_KO.4 3.9894 0.3489 100 2493.222 2493.222 0.1 40864.3

IPI:IPI00 4 4 26.10% 115 13397 9.8 U Tax_Id=10090 Gene_Symbol=- 13 kDa protein FOXO_KO.1 4.6764 0.452 100 1869.773 1868.769 0.1 73724.9FOXO_KO.1 2.7883 0.2672 99.5 1869.773 1868.769 0.4 848001.3

FOXO_KO.1 4.7916 0.3189 100 1735.729 1734.728 -1.4 210784.1FOXO_KO.1 3.3115 0.2928 99.9 1734.727 1734.728 -0.6 447011.1

IPI:IPI00 5 5 25.60% 129 14045 11.1 U Tax_Id=10090 Gene_Symbol=H2afj Histone H2A.J IPI:IPI00 5 5 25.40% 130 14135 11.1 U Tax_Id=10090 Gene_Symbol=Hist1h2an;Hist1h2ao;Hist1h2ad;Hist1h2ac;Hist1h2ae;Hist1h2ag;Hist1h2ai;RP23-480B19.10;Hist1h2ab Histone H2A type 1 IPI:IPI00 5 5 23.10% 143 15143 10.7 U Tax_Id=10090 Gene_Symbol=H2afx Histone H2A.x IPI:IPI00 5 5 25.40% 130 14150 11.1 U Tax_Id=10090 Gene_Symbol=Hist1h2ak Histone H2A type 1-K IPI:IPI00 5 5 25.80% 128 13950 11 U Tax_Id=10090 Gene_Symbol=Hist1h2ah Histone H2A type 1-H IPI:IPI00 5 5 25.40% 130 14162 11.1 U Tax_Id=10090 Gene_Symbol=Hist1h2af Histone H2A type 1-F IPI:IPI00 5 5 25.40% 130 14121 11.1 U Tax_Id=10090 Gene_Symbol=Hist3h2a Histone H2A type 3

FOXO_KO.6 4.8747 0.4595 100 2916.591 2915.588 -0.1 11345.1FOXO_KO.6 5.5739 0.4862 100 2916.591 2915.588 0 76905FOXO_KO.6 4.256 0.2341 99.7 3274.757 3272.752 -0.6 34254.6FOXO_KO.6 4.5578 0.4539 100 3402.85 3400.847 -1.1 44576.5FOXO_KO.6 4.9354 0.3773 99.9 3400.847 3400.847 -0.1 240780.6

IPI:IPI00 3 4 25.60% 117 13336 5.1 U Tax_Id=10090 Gene_Symbol=Ywhaz Putative uncharacterized protein IPI:IPI00 3 4 66.70% 45 5089 4.6 U Tax_Id=10090 Gene_Symbol=Ywhaz 5 kDa protein

FOXO_KO.1 4.2795 0.3248 100 1901.823 1901.819 2.1 176995.6FOXO_KO.1 3.5285 0.4099 99.9 1901.82 1901.819 0.3 374715.6FOXO_KO.8 5.4052 0.4367 100 1548.708 1548.714 -3.4 4614811

contamina 18 34 25.50% 483 53748 5.4 U no descriptionFOXO_KO.3 4.6683 0.5496 100 1847.806 1847.805 0.5 107672.2FOXO_KO.3 7.2824 0.5712 100 2035.062 2034.058 0.4 177045.2FOXO_KO.3 4.2492 0.4418 100 2035.073 2034.058 6.1 115152.5FOXO_KO.3 5.7888 0.4651 100 3324.697 3323.694 -0.1 133010.9FOXO_KO.3 6.2574 0.4042 100 3325.699 3323.694 -0.5 335599.8FOXO_KO.3 3.499 0.2971 99.9 1793.9 1792.879 9.8 162155.7FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715FOXO_KO.2 3.8624 0.4035 100 1352.677 1352.677 -0.1 244658.3FOXO_KO.1 3.7357 0.2457 99.9 1480.77 1480.772 -1 323037.5FOXO_KO.1 3.9141 0.4453 100 1926.928 1925.927 -1.4 285097.9FOXO_KO.1 2.3294 0.4073 100 1084.461 1084.462 -0.8 62485.5FOXO_KO.1 2.6716 0.33 99.9 1084.462 1084.462 0.1 260885.7FOXO_KO.1 5.2435 0.4477 100 1798.834 1797.832 -0.8 319330.1FOXO_KO.3 4.3494 0.4666 100 1419.747 1419.748 -0.7 725049.9FOXO_KO.2 5.1816 0.4705 100 2109.016 2109.013 1.5 81687.8FOXO_KO_w 2.3764 0.3478 100 1079.513 1079.512 1.5 20194.2FOXO_KO.2 4.654 0.379 100 1345.679 1344.675 -0.1 336361.8

IPI:IPI00 17 79 25.40% 646 70745 5.3 U Tax_Id=10090 Gene_Symbol=- 71 kDa protein FOXO_KO.1 5.2545 0.4539 100 1650.796 1649.795 -1.8 214685.6FOXO_KO.1 3.1871 0.3056 99.9 1410.667 1410.668 -1 235341.9FOXO_KO.1 3.2851 0.3098 99.9 1252.66 1252.661 -0.5 194761.1FOXO_KO.2 3.4794 0.3266 100 1480.751 1480.754 -2.5 196915.1FOXO_KO.2 3.0387 0.2225 99.5 1480.755 1480.754 0.5 102785.9FOXO_KO.2 3.1533 0.3932 100 1253.616 1253.616 0.2 319502.1FOXO_KO.3 7.1018 0.6143 100 2261.15 2260.146 0.7 102609.9FOXO_KO.3 3.9984 0.4844 100 2261.152 2260.146 1.4 102527.8FOXO_KO.2 4.6041 0.4777 100 2775.328 2774.327 -0.9 24134.5

FOXO_KO.6 4.375 0.4398 100 3773.936 3772.92 3.4 19698.3FOXO_KO.6 6.5954 0.4503 100 2516.306 2514.309 -3.8 18120.2FOXO_KO.2 4.6094 0.3004 99.9 3974.966 3972.965 -1.3 87844.9FOXO_KO.2 3.7135 0.2595 99.9 1277.62 1277.619 0.1 184476FOXO_KO.2 7.4347 0.3569 100 3005.415 3004.41 0.3 243308.8FOXO_KO.1 5.5673 0.4878 100 1745.809 1745.809 -0.1 36310.4FOXO_KO.8 6.496 0.3136 100 2246.069 2245.073 -3.1 79248.9FOXO_KO.8 4.4007 0.3547 99.9 2246.063 2245.073 -6 274205.8

IPI:IPI00 20 29 25.40% 623 69633 8.6 U Tax_Id=10090 Gene_Symbol=Syncrip Isoform 1 of Heterogeneous nuclear ribonucleoprotein Q IPI:IPI00 20 29 28.10% 562 62672 7.6 U Tax_Id=10090 Gene_Symbol=Syncrip Isoform 2 of Heterogeneous nuclear ribonucleoprotein Q

FOXO_KO.2 6.4546 0.5262 100 2442.249 2442.251 -0.7 219569.4FOXO_KO.2 3.3528 0.3466 99.9 2443.258 2442.251 1.4 142636.1FOXO_KO.2 6.3109 0.4766 100 2016.01 2015.008 -0.7 137071FOXO_KO.2 3.9697 0.4296 100 2015.006 2015.008 -1.1 152973.9FOXO_KO.3 7.5095 0.5316 100 2335.239 2334.234 0.5 154646.8FOXO_KO.3 4.6475 0.2304 99.9 2334.236 2334.234 0.9 162982.5FOXO_KO.3 5.1889 0.45 100 3458.762 3457.76 -0.3 99755.6FOXO_KO.3 4.6772 0.3571 99.9 3459.767 3457.76 0.1 172244.8FOXO_KO.3 4.7491 0.4158 100 1709.86 1708.854 1.6 239748.8FOXO_KO.4 3.407 0.2798 99.9 1594.809 1593.805 0.7 200332.8FOXO_KO.2 4.9566 0.4301 100 1943.974 1942.976 -2.6 342012.1FOXO_KO.3 5.4042 0.3051 99.9 2883.409 2881.408 -1.8 233202.4FOXO_KO.3 6.2722 0.3987 100 2655.246 2654.244 -0.8 125991.5FOXO_KO.3 4.431 0.4491 100 2655.247 2654.244 -0.3 198916.4FOXO_KO.2 3.5692 0.4782 100 1473.78 1473.78 0.1 177980FOXO_KO.2 3.4146 0.4075 100 1313.597 1312.596 -1.7 159508.8FOXO_KO.2 5.1616 0.3539 99.9 2933.401 2932.407 -3.2 278294.4FOXO_KO.2 4.5117 0.3723 99.9 2934.403 2932.407 -3.6 413355.5FOXO_KO.2 5.808 0.4859 100 2043.048 2042.044 0.4 141092.1FOXO_KO.2 3.7365 0.4454 100 2043.044 2042.044 -1.7 187016.3

IPI:IPI00 5 6 25.40% 248 27745 10.4 U Tax_Id=10090 Gene_Symbol=Sfrs1;LOC100048559 Isoform 1 of Splicing factor, arginine/serine-rich 1 IPI:IPI00 5 6 32.10% 196 21807 8.7 U Tax_Id=10090 Gene_Symbol=Sfrs1 Isoform 3 of Splicing factor, arginine/serine-rich 1 IPI:IPI00 5 6 31.30% 201 22320 8 U Tax_Id=10090 Gene_Symbol=Sfrs1 Isoform 2 of Splicing factor, arginine/serine-rich 1

FOXO_KO.1 3.5887 0.2069 99.9 1257.636 1257.636 -0.1 388214.8FOXO_KO.3 4.2939 0.4286 100 2542.164 2541.168 -2.9 47855.7FOXO_KO.1 2.8407 0.3818 100 1123.435 1123.433 1.7 227392FOXO_KO.1 3.3144 0.4582 100 1417.605 1417.605 -0.4 275590.1FOXO_KO_w 2.8061 0.3396 99.9 1112.544 1112.54 3 33756.9

IPI:IPI00 4 8 25.40% 185 20160 6 U Tax_Id=10090 Gene_Symbol=Mccc2 Putative uncharacterized protein FOXO_KO.1 6.1774 0.549 100 2057.919 2057.919 -0.4 118537FOXO_KO.1 3.7935 0.3793 99.9 2057.918 2057.919 -0.7 286133.2FOXO_KO.4 3.8003 0.4763 100 2948.473 2947.464 1.8 16367.8FOXO_KO.4 3.0087 0.2964 99.6 2948.467 2947.464 -0.1 67651.6

IPI:IPI002 9 23 25.30% 463 50976 5.5 U Tax_Id=10090 Gene_Symbol=Hnrnpk Isoform 1 of Heterogeneous nuclear ribonucleoprotein K IPI:IPI002 9 23 25.20% 464 51028 5.3 U Tax_Id=10090 Gene_Symbol=Hnrnpk Isoform 2 of Heterogeneous nuclear ribonucleoprotein K

FOXO_KO.9 5.3147 0.4099 100 1579.703 1579.706 -1.8 225521.2FOXO_KO.8 4.7697 0.4788 100 1735.801 1735.807 -3.4 139915FOXO_KO.8 4.1325 0.2851 99.9 1735.801 1735.807 -3.4 1996603

FOXO_KO.1 4.9431 0.4986 100 1781.802 1780.798 0 325850.2FOXO_KO.3 2.7025 0.3196 99.5 4137.006 4134.998 0.4 10758.7FOXO_KO_w 2.3743 0.2836 99.8 998.386 998.3884 -2.4 72628.7FOXO_KO.1 6.3971 0.5799 100 2068.976 2068.978 -0.8 63290.2FOXO_KO.1 3.8455 0.3934 100 1259.573 1259.575 -1.4 309421.7FOXO_KO.3 4.6939 0.4545 100 3830.95 3829.945 0.4 66726.4

IPI:IPI00 8 14 25.30% 407 45021 7.9 U Tax_Id=10090 Gene_Symbol=Bhmt Betaine--homocysteine S-methyltransferase 1 IPI:IPI00 8 14 25.30% 407 44964 8.1 U Tax_Id=10090 Gene_Symbol=Bhmt-ps1 Betaine-homocysteine methyltransferase, pseudogene 1

FOXO_KO.1 5.8809 0.5255 100 1817.903 1816.898 1 193570.5FOXO_KO.2 5.8761 0.5324 100 2410.129 2408.119 1.6 86062.1FOXO_KO.2 6.5921 0.5558 100 2453.169 2452.166 -0.3 51264.6FOXO_KO.2 5.2472 0.353 99.9 2453.169 2452.166 -0.3 158392.4FOXO_KO.5 4.0027 0.2072 99.5 2950.503 2949.503 -1.1 93307.8FOXO_KO.5 6.5364 0.5613 100 2822.412 2821.408 0.1 23734.9FOXO_KO.5 4.6517 0.3981 100 2822.412 2821.408 0.3 32260.8FOXO_KO.4 4.0038 0.3337 100 1863.956 1861.948 0.6 133977.3

IPI:IPI00 4 5 24.90% 217 24831 9.9 U Tax_Id=10090 Gene_Symbol=Rpl10a;Gm15451 ribosomal protein L10A FOXO_KO.3 3.4929 0.3214 99.9 1900.969 1899.967 -0.7 141350.8

* FOXO_KO.1 5.0896 0.5017 100 1892.823 1892.827 -1.9 108593.5* FOXO_KO.1 3.3141 0.2915 99.9 1893.826 1892.827 -2.3 265993.4

FOXO_KO.6 5.3958 0.5076 100 2548.356 2547.353 -0.1 125017.7IPI:IPI00 2 2 24.80% 145 16057 9.7 U Tax_Id=10090 Gene_Symbol=Rplp0 16 kDa protein

FOXO_KO.2 4.6822 0.2805 100 1660.856 1660.857 -0.7 159848.7FOXO_KO.1 3.8377 0.3264 100 2180.099 2180.102 -1.3 54730.3

IPI:IPI00 1 1 24.70% 89 10366 7.4 U Tax_Id=10090 Gene_Symbol=Dynll1 Dynein light chain 1, cytoplasmic * FOXO_KO.2 6.8846 0.1616 100 2515.048 2514.043 0.8 105065.5IPI:IPI00 2 2 24.70% 89 10350 7.4 U Tax_Id=10090 Gene_Symbol=Dynll2 Dynein light chain 2, cytoplasmic IPI:IPI00 2 2 41.50% 53 6109 8.1 U Tax_Id=10090 Gene_Symbol=Dynll2 6 kDa protein

FOXO_KO.2 6.5408 0.5849 100 2488.979 2487.973 0.9 97536.5FOXO_KO.2 5.3118 0.5423 100 2488.978 2487.973 0.6 305173.2

IPI:IPI00 2 2 24.60% 276 30634 5 U Tax_Id=10090 Gene_Symbol=Eef1d MCG22130, isoform CRA_b IPI:IPI00 2 2 35.80% 190 21763 4.9 U Tax_Id=10090 Gene_Symbol=Eef1d 22 kDa protein IPI:IPI00 2 2 12.30% 552 61392 7.4 U Tax_Id=10090 Gene_Symbol=Eef1d 61 kDa protein IPI:IPI00 2 2 24.20% 281 31292 5.1 U Tax_Id=10090 Gene_Symbol=Eef1d eukaryotic translation elongation factor 1 delta isoform b

FOXO_KO.1 4.6007 0.435 100 3277.322 3276.322 -1.2 42789.3FOXO_KO.4 4.1606 0.2211 99.6 4519.276 4517.275 -1.3 106642.7

IPI:IPI00 3 6 24.50% 184 21413 9 U Tax_Id=10090 Gene_Symbol=Ssb Sjogren syndrome antigen B IPI:IPI00 3 6 28.30% 159 18640 9.3 U Tax_Id=10090 Gene_Symbol=Ssb 19 kDa protein

FOXO_KO.1 5.3341 0.4309 100 2075.047 2074.045 -0.8 54881.1FOXO_KO.3 6.1201 0.4829 100 2081.008 2078.992 4.5 96574.6FOXO_KO.4 5.7128 0.4729 100 3134.563 3132.567 -3.4 58719.7

IPI:IPI00 10 13 24.10% 245 28343 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 10 IPI:IPI00 10 13 23.80% 248 28529 4.7 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 8 IPI:IPI00 10 13 23.80% 248 28557 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 6 IPI:IPI00 10 13 20.80% 284 32637 4.7 U Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 2 IPI:IPI00 10 13 23.50% 251 28748 4.8 U Tax_Id=10090 Gene_Symbol=Tpm1 29 kDa protein

FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4

FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9FOXO_KO.1 3.8103 0.3227 99.9 1960.006 1960.006 0.1 332255.9FOXO_KO.1 4.0147 0.3765 100 1315.767 1314.763 0.3 257598FOXO_KO.1 4.389 0.2889 100 1800.986 1799.986 -2.2 139234.9FOXO_KO.1 3.8697 0.3464 99.9 1799.984 1799.986 -1.2 369849FOXO_KO.1 3.5517 0.2115 99.8 1673.895 1671.891 -1.8 211568.5

IPI:IPI00 3 7 24.10% 158 17443 8.3 U Tax_Id=10090 Gene_Symbol=Hspa8 17 kDa protein IPI:IPI00 3 7 32.80% 116 12814 8.1 U Tax_Id=10090 Gene_Symbol=Hspa8 13 kDa protein

FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.1 5.2545 0.4539 100 1650.796 1649.795 -1.8 214685.6FOXO_KO.1 3.1871 0.3056 99.9 1410.667 1410.668 -1 235341.9

IPI:IPI00 8 13 24.00% 563 61379 8 U Tax_Id=10090 Gene_Symbol=Mccc2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial * FOXO_KO.1 6.2492 0.4025 100 2277.999 2276.998 -1 69813.5* FOXO_KO.4 3.3891 0.4188 99.9 4429.196 4427.183 1.4 12184.7

FOXO_KO.1 6.1774 0.549 100 2057.919 2057.919 -0.4 118537FOXO_KO.1 3.7935 0.3793 99.9 2057.918 2057.919 -0.7 286133.2FOXO_KO.4 3.8003 0.4763 100 2948.473 2947.464 1.8 16367.8FOXO_KO.4 3.0087 0.2964 99.6 2948.467 2947.464 -0.1 67651.6FOXO_KO.9 5.9939 0.3276 100 1705.76 1704.761 -2.8 155360FOXO_KO.2 4.1833 0.387 100 1515.752 1514.749 0.3 238446.1

IPI:IPI00 2 2 23.60% 182 20414 9.5 U Tax_Id=10090 Gene_Symbol=Rps5 20 kDa protein IPI:IPI00 2 2 21.10% 204 22876 9.7 U Tax_Id=10090 Gene_Symbol=Rps5 ribosomal protein S5

FOXO_KO.5 4.5847 0.3321 99.9 3066.695 3065.69 0.6 64851.5FOXO_KO.3 6.0252 0.4998 100 1632.836 1631.831 0.9 222952

IPI:IPI00 2 3 23.50% 183 20811 5.3 U Tax_Id=10090 Gene_Symbol=Cbx3 Chromobox homolog 3 IPI:IPI00 2 3 39.10% 110 12557 8 U Tax_Id=10090 Gene_Symbol=Cbx3 13 kDa protein

FOXO_KO.1 5.2168 0.4346 100 1661.826 1661.827 -0.6 180524.3FOXO_KO.4 4.8961 0.3198 99.9 3382.515 3382.506 2.7 104980.4

IPI:IPI00 1 1 23.50% 153 16494 8.8 U Tax_Id=10090 Gene_Symbol=Echs1 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, isoform CRA_c FOXO_KO.5 4.1627 0.3597 99.9 3785.917 3783.911 -0.2 11941.8

IPI:IPI00 2 2 23.50% 68 7387 11.7 U Tax_Id=10090 Gene_Symbol=Fam82a2 Novel protein IPI:IPI00 2 2 22.20% 72 7784 11.5 U Tax_Id=10090 Gene_Symbol=Fam82a2 Novel protein IPI:IPI00 2 2 19.50% 82 8693 11.2 U Tax_Id=10090 Gene_Symbol=Fam82a2 Novel protein

FOXO_KO.1 4.3271 0.5581 100 1854.803 1854.802 0.9 108065.1FOXO_KO.1 3.572 0.3546 99.9 1855.804 1854.802 -0.8 211135.8

IPI:IPI00 6 6 23.40% 218 25970 8 U Tax_Id=10090 Gene_Symbol=Gstm1 Glutathione S-transferase Mu 1 FOXO_KO.1 3.3644 0.2152 99.8 1594.717 1593.699 9.5 416145.4FOXO_KO.1 5.2026 0.4242 100 1750.803 1749.8 -0.1 261194.2FOXO_KO.1 2.6738 0.3064 99.8 1444.632 1443.632 -2.2 462928FOXO_KO.1 2.6907 0.4523 100 1287.529 1287.531 -1.8 342630.5FOXO_KO.1 3.5502 0.4729 100 1390.663 1390.663 -0.1 237705.5

* FOXO_KO.3 4.9831 0.0757 99.6 1803.839 1801.832 0.1 200329.5IPI:IPI00 4 11 23.40% 235 25104 10.3 U Tax_Id=10090 Gene_Symbol=Rps2 Putative uncharacterized protein IPI:IPI00 4 11 18.80% 293 31231 10.2 U Tax_Id=10090 Gene_Symbol=Rps2;Gm14583;Gm8553 40S ribosomal protein S2 IPI:IPI006 4 11 18.80% 293 31215 10.3 U Tax_Id=10090 Gene_Symbol=Gm5786 hypothetical protein IPI:IPI00 4 11 19.30% 285 30372 10 U Tax_Id=10090 Gene_Symbol=Gm16408 hypothetical protein

FOXO_KO.1 3.8773 0.2957 100 1315.688 1315.689 -0.6 234571.9FOXO_KO.5 6.1524 0.4522 100 3687.998 3685.987 1.2 28799.6FOXO_KO.4 6.6858 0.5034 100 2154.142 2153.138 0.5 257113.6FOXO_KO.1 3.2075 0.3515 100 1463.715 1463.717 -1.3 210517.6

IPI:IPI00 1 1 23.30% 146 16318 4.9 U Tax_Id=10090 Gene_Symbol=Cyb5b Cytochrome b5 type B * FOXO_KO.3 6.2347 0.4586 100 3596.635 3596.641 -1.8 102403.9contamina 11 76 23.10% 654 72379 5.2 U owl|P07823| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN...

FOXO_KO.2 5.7379 0.4723 100 3076.489 3074.487 -1.5 93245.3FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.1 3.1757 0.3987 100 1566.778 1566.78 -0.9 273199.2FOXO_KO.1 5.3256 0.3394 100 1677.808 1677.808 -0.1 160962.8FOXO_KO.3 6.8992 0.5651 100 2150.004 2148.997 1.7 2067927FOXO_KO.2 3.8378 0.3699 100 1512.751 1512.752 -0.4 150874.8FOXO_KO.2 6.5779 0.3968 100 2489.321 2488.314 1.5 55541FOXO_KO.2 3.4612 0.3777 99.9 1974.908 1974.908 0.1 285365.9FOXO_KO.2 8.4716 0.5582 100 2175.044 2174.04 0.3 208279.7FOXO_KO.2 3.9334 0.3146 99.9 2174.036 2174.04 -1.7 739911FOXO_KO.2 3.1931 0.3072 99.9 1397.789 1397.789 -0.1 165801.8

IPI:IPI00 8 12 23.10% 412 46585 8.2 U Tax_Id=10090 Gene_Symbol=Ass1 Argininosuccinate synthase FOXO_KO.3 5.8473 0.549 100 2659.273 2658.268 0.6 77937.7FOXO_KO.3 3.4512 0.4589 99.9 2658.269 2658.268 0.2 181683FOXO_KO.4 4.2195 0.3817 99.9 3461.731 3460.731 -0.8 90324.7FOXO_KO.3 5.4006 0.5112 100 2416.15 2415.15 -1.7 86668.6FOXO_KO.3 4.24 0.4625 100 2416.16 2415.15 2.8 153058.4FOXO_KO.3 4.4394 0.3407 99.9 2661.242 2661.232 3.8 121055.7

* FOXO_KO.2 3.8528 0.4076 99.9 2099.064 2099.065 -0.9 95429.9* FOXO_KO.1 4.9788 0.4389 100 2228.159 2227.16 -2.1 214640.1IPI:IPI00 4 8 23.10% 208 24152 10.2 U Tax_Id=10090 Gene_Symbol=Gm6998 similar to ribosomal protein S8 isoform 2 IPI:IPI008 4 8 21.70% 221 25736 10.3 U Tax_Id=10090 Gene_Symbol=Gm14289;Gm14438 similar to ribosomal protein S8

FOXO_KO.2 4.9554 0.4491 100 1788.748 1787.748 -1.4 548899FOXO_KO.1 3.3225 0.2386 99.8 1316.686 1314.679 0.7 307943.8FOXO_KO.1 4.4379 0.4429 100 1507.782 1506.78 -1 275448.3FOXO_KO.2 3.1759 0.3679 100 951.4775 951.4782 -0.7 50659

IPI:IPI00 6 6 22.90% 266 29990 10.5 U Tax_Id=10090 Gene_Symbol=Gm5044 hypothetical protein isoform 2 IPI:IPI00 6 6 22.90% 266 29965 10.6 U Tax_Id=10090 Gene_Symbol=Gm16477 hypothetical protein IPI:IPI00 6 6 22.90% 266 30083 10.4 U Tax_Id=10090 Gene_Symbol=Gm4970 hypothetical protein IPI:IPI00 6 6 21.20% 288 32625 10.6 U Tax_Id=10090 Gene_Symbol=Gm5619 hypothetical protein IPI:IPI00 6 6 23.10% 264 29896 10.5 U Tax_Id=10090 Gene_Symbol=Gm16375 hypothetical protein IPI:IPI00 6 6 22.90% 266 30038 10.5 U Tax_Id=10090 Gene_Symbol=Gm6347 hypothetical protein isoform 1 IPI:IPI00 6 6 22.90% 266 29977 10.6 U Tax_Id=10090 Gene_Symbol=Rpl7a;Gm8226 60S ribosomal protein L7a

FOXO_KO.1 2.8801 0.2496 99.8 1216.631 1216.632 -1.2 437177.4FOXO_KO.2 3.4099 0.3996 100 1811.018 1811.017 0.2 159626.6FOXO_KO.1 3.9327 0.4417 100 1345.731 1345.732 -0.7 236899.1FOXO_KO.1 4.595 0.3416 99.9 2270.148 2269.149 -1.8 170991FOXO_KO.1 3.9658 0.3856 100 1700.776 1700.78 -1.9 354713.2FOXO_KO.1 5.6731 0.6061 100 2141.05 2141.054 -2.1 62213.7

IPI:IPI00 3 4 22.70% 211 23863 6.3 U Tax_Id=10090 Gene_Symbol=Farp1 Putative uncharacterized protein FOXO_KO.1 3.2766 0.3916 100 1523.707 1523.71 -2.3 224674.3

FOXO_KO.5 4.3171 0.3298 99.9 3204.557 3203.553 0.3 43758.2FOXO_KO.4 3.7986 0.3388 99.9 3783.881 3781.87 1.2 107135

IPI:IPI00 4 4 22.40% 192 22279 6.4 U Tax_Id=10090 Gene_Symbol=LOC100046735 similar to Serine/arginine repetitive matrix protein 2 FOXO_KO.2 6.5049 0.3722 100 2674.136 2673.137 -1.6 59702.1FOXO_KO.2 6.1346 0.4616 100 2674.137 2673.137 -1.1 229087.7FOXO_KO.1 6.4949 0.4869 100 2506.259 2505.258 -0.9 48679.2FOXO_KO.1 4.0731 0.2917 99.9 2505.254 2505.258 -1.7 171995.1

IPI:IPI00 2 3 22.30% 130 14013 10.9 U Tax_Id=10090 Gene_Symbol=Hist2h2ab;Hist2h2ac Histone H2A type 2-B FOXO_KO.6 5.0228 0.4946 100 2934.548 2933.544 0.1 23636.3FOXO_KO.6 4.4444 0.5543 100 2933.546 2933.544 0.7 59417.4

IPI:IPI00 3 3 22.20% 180 20648 5 U Tax_Id=10090 Gene_Symbol=Mup2;Mup7 major urinary protein 2 precursor IPI:IPI00 3 3 22.20% 180 20648 5.1 U Tax_Id=10090 Gene_Symbol=Mup1;Mup13;Mup14;CU041261.1 Major urinary protein 1 IPI:IPI00 3 3 22.10% 181 20763 4.9 U Tax_Id=10090 Gene_Symbol=Mup11;Mup1;Mup2;Mup7 major urinary protein 11 IPI:IPI00 3 3 22.20% 180 20668 4.9 U Tax_Id=10090 Gene_Symbol=Mup13;Mup14 Novel member of the major urinary protein (Mup) gene family IPI:IPI00 3 3 22.10% 181 20761 5.3 U Tax_Id=10090 Gene_Symbol=Mup11 Putative uncharacterized protein IPI:IPI00 3 3 17.00% 235 26833 5.2 U Tax_Id=10090 Gene_Symbol=Mup1 major urinary protein 1 isoform a IPI:IPI00 3 3 22.20% 180 20681 5 U Tax_Id=10090 Gene_Symbol=Mup10 major urinary protein 10 IPI:IPI00 3 3 26.50% 151 17561 4.8 U Tax_Id=10090 Gene_Symbol=Mup2;Mup7 18 kDa protein IPI:IPI00 3 3 26.50% 151 17560 4.9 U Tax_Id=10090 Gene_Symbol=CU041261.1 18 kDa protein IPI:IPI00 3 3 21.40% 187 21396 4.9 U Tax_Id=10090 Gene_Symbol=Mup9 Major urinary protein 2 IPI:IPI00 3 3 17.00% 235 26847 5.2 U Tax_Id=10090 Gene_Symbol=Mup15 similar to major urinary protein 1 IPI:IPI00 3 3 17.00% 235 26848 5 U Tax_Id=10090 Gene_Symbol=Mup19;Mup1;Mup9;Mup16 Major urinary protein 2 IPI:IPI00 3 3 16.90% 236 26962 5 U Tax_Id=10090 Gene_Symbol=Mup18 similar to major urinary protein 1 IPI:IPI008 3 3 26.50% 151 17560 4.9 U Tax_Id=10090 Gene_Symbol=- Major urinary proteins 11 and 8 (Fragment) IPI:IPI00 3 3 22.20% 180 20649 4.9 U Tax_Id=10090 Gene_Symbol=Mup9;CU104690.1;LOC100189605 Major urinary protein 6 IPI:IPI00 3 3 17.00% 235 26847 5.2 U Tax_Id=10090 Gene_Symbol=Mup12 similar to major urinary protein 1 IPI:IPI00 3 3 17.00% 235 26867 5 U Tax_Id=10090 Gene_Symbol=Mup14 similar to major urinary protein 1 IPI:IPI00 3 3 22.20% 180 20634 5.1 U Tax_Id=10090 Gene_Symbol=Mup1 major urinary protein 1 isoform b IPI:IPI00 3 3 22.20% 180 20647 5.2 U Tax_Id=10090 Gene_Symbol=CU041261.1 Novel member of the major urinary protein (Mup) gene family

FOXO_KO.1 3.1845 0.4392 99.9 2153.963 2152.964 -1.7 163637.5FOXO_KO.3 4.5157 0.424 100 2471.174 2471.176 -0.6 30200.9FOXO_KO.3 4.4789 0.4434 100 2472.181 2471.176 0.8 164469.9

IPI:IPI006 3 17 22.20% 108 12059 5.3 U Tax_Id=10090 Gene_Symbol=LOC641192 similar to heat shock protein 70 cognate FOXO_KO.2 3.7135 0.2595 99.9 1277.62 1277.619 0.1 184476FOXO_KO.2 7.4347 0.3569 100 3005.415 3004.41 0.3 243308.8FOXO_KO.1 5.5673 0.4878 100 1745.809 1745.809 -0.1 36310.4

IPI:IPI00 10 11 22.10% 637 72680 6.4 U Tax_Id=10090 Gene_Symbol=Prmt5 Protein arginine N-methyltransferase 5 * FOXO_KO.3 4.8196 0.4653 100 1786.908 1785.905 -0.2 209816.8

FOXO_KO.5 3.7584 0.3508 99.9 3690.743 3689.757 -4.5 28983.7FOXO_KO.3 5.2445 0.4225 100 2856.479 2855.475 0 144385.9FOXO_KO.2 3.5974 0.2161 99.6 2198.147 2198.148 -0.7 145758.3

* FOXO_KO.4 5.0088 0.3431 99.9 3289.613 3288.609 0.1 90955.4* FOXO_KO.3 5.838 0.5663 100 2171.051 2170.055 -3.5 174533* FOXO_KO.1 5.0089 0.4391 100 2110.009 2109.007 -0.4 102328.4* FOXO_KO.2 3.2978 0.2865 99.8 2109.008 2109.007 0.7 532754* FOXO_KO.2 5.4459 0.3864 100 1852.871 1851.869 -0.9 223831.9* FOXO_KO.2 4.4003 0.2986 99.9 1852.869 1851.869 -1.9 311738.8IPI:IPI003 8 26 22.10% 403 46124 10.2 U Tax_Id=10090 Gene_Symbol=Rpl3 60S ribosomal protein L3

IPI:IPI00 8 26 22.10% 403 46110 10.2 U Tax_Id=10090 Gene_Symbol=Rpl3;Gm16468 ribosomal protein L3 IPI:IPI00 8 26 22.10% 403 46102 10.2 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 1 IPI:IPI00 8 26 25.10% 354 40132 10.2 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 3 IPI:IPI007 8 26 23.10% 385 44102 10.3 U Tax_Id=10090 Gene_Symbol=LOC674810 similar to Ribosomal protein L3 IPI:IPI00 8 26 25.10% 354 40140 10.2 U Tax_Id=10090 Gene_Symbol=Gm16468 similar to ribosomal protein L3 isoform 3

FOXO_KO.2 5.4225 0.5099 100 1763.922 1761.917 -0.8 418329.8FOXO_KO.2 3.5993 0.3585 99.9 1761.915 1761.917 -1.4 549226.4FOXO_KO.8 4.2119 0.4213 100 1592.751 1591.753 -3.4 108081FOXO_KO.3 4.7221 0.4499 100 2972.523 2971.519 0.1 34723.6FOXO_KO.3 3.6762 0.4546 100 2973.503 2971.519 -7.8 96087FOXO_KO_w 2.8484 0.3534 100 1342.574 1342.576 -1 10932.4FOXO_KO_w 4.0559 0.4968 100 1342.575 1342.576 -0.9 293345.8FOXO_KO.3 4.4614 0.3649 99.9 3776.813 3774.796 2.7 17939.6

IPI:IPI00 6 6 22.10% 172 19861 4.8 U Tax_Id=10090 Gene_Symbol=2900073G15Rik Putative uncharacterized protein FOXO_KO.2 5.9589 0.5379 100 2021.932 2021.931 0.5 133458.5FOXO_KO.2 3.955 0.4821 100 2021.931 2021.931 -0.1 280987.1FOXO_KO.2 3.2987 0.4178 99.9 2022.932 2021.931 -1 183959FOXO_KO.2 4.8978 0.2517 100 2433.131 2432.128 -0.2 94538.5FOXO_KO.2 3.8695 0.3953 99.9 2433.129 2432.128 -1.1 169231FOXO_KO.1 4.0631 0.3864 100 1415.632 1415.632 -0.3 300836.3

IPI:IPI007 3 5 22.10% 145 17037 10.3 U Tax_Id=10090 Gene_Symbol=Gm7121 similar to insulinoma protein FOXO_KO_w 4.0933 0.4277 100 1481.801 1481.803 -1.3 52404.4FOXO_KO.8 3.4335 0.3056 99.9 1353.704 1353.708 -3 284062FOXO_KO.4 4.7739 0.4423 100 2054.003 2053.017 -8.4 71482.1

IPI:IPI00 3 4 22.10% 136 15798 10.6 U Tax_Id=10090 Gene_Symbol=Rpl27;Gm6199;Gm11518 60S ribosomal protein L27 * FOXO_KO.1 3.6765 0.2699 99.9 2273.094 2272.095 -2.1 52049.8* FOXO_KO.1 4.7539 0.4505 100 2273.097 2272.095 -0.8 113871.6

FOXO_KO.1 2.4157 0.4789 100 1049.552 1049.551 0.3 462737IPI:IPI00 1 2 21.90% 128 14174 8.5 U Tax_Id=10090 Gene_Symbol=Nhp2l1;Gm5616 NHP2-like protein 1 * FOXO_KO.5 5.5486 0.547 100 3137.642 3136.631 2.5 59791.3IPI:IPI00 6 8 21.80% 325 35328 9.2 U Tax_Id=10090 Gene_Symbol=Cyc1 Isoform 1 of Cytochrome c1, heme protein, mitochondrial IPI:IPI00 6 8 26.70% 266 29498 7 U Tax_Id=10090 Gene_Symbol=Cyc1 Isoform 2 of Cytochrome c1, heme protein, mitochondrial

FOXO_KO.9 4.3272 0.4064 100 1534.718 1534.721 -1.9 180266.5FOXO_KO.2 7.138 0.502 100 2353.007 2352.012 -3.5 138269.3FOXO_KO.2 5.7025 0.3873 100 2635.183 2634.181 -0.3 123138.8FOXO_KO.2 5.7505 0.4165 100 2635.182 2634.181 -0.9 171909.9FOXO_KO.3 4.7462 0.3159 99.9 2655.26 2654.256 0.5 165743.3FOXO_KO.1 2.7724 0.2738 99.8 1263.549 1263.55 -1.3 38468.7

IPI:IPI00 2 3 21.70% 157 16959 6.2 U Tax_Id=10090 Gene_Symbol=Plin2 Adipose differentiation related protein FOXO_KO.1 3.9712 0.2327 99.9 1263.641 1263.643 -1.4 277906.1FOXO_KO.3 5.578 0.4668 100 2514.227 2512.216 1.5 37421.8

IPI:IPI00 2 4 21.60% 167 18128 5.1 U Tax_Id=10090 Gene_Symbol=Wdr77 18 kDa protein FOXO_KO.2 3.9131 0.5053 100 2480.207 2480.215 -3.2 109271.3FOXO_KO.1 3.0859 0.383 100 1401.596 1401.595 0.4 174795.5

IPI:IPI00 7 25 21.50% 354 39964 10.1 U Tax_Id=10090 Gene_Symbol=Gm12816 similar to ribosomal protein L3 FOXO_KO.2 5.4225 0.5099 100 1763.922 1761.917 -0.8 418329.8FOXO_KO.2 3.5993 0.3585 99.9 1761.915 1761.917 -1.4 549226.4FOXO_KO.3 4.7221 0.4499 100 2972.523 2971.519 0.1 34723.6

FOXO_KO.3 3.6762 0.4546 100 2973.503 2971.519 -7.8 96087FOXO_KO_w 2.8484 0.3534 100 1342.574 1342.576 -1 10932.4FOXO_KO_w 4.0559 0.4968 100 1342.575 1342.576 -0.9 293345.8FOXO_KO.3 4.4614 0.3649 99.9 3776.813 3774.796 2.7 17939.6

IPI:IPI00 6 8 21.40% 406 46154 5.5 U Tax_Id=10090 Gene_Symbol=Eif4a1 Eukaryotic initiation factor 4A-I FOXO_KO.5 4.9107 0.4904 100 4167.862 4166.856 0.8 10920.2FOXO_KO.3 5.1986 0.4433 100 1556.713 1555.713 -2.4 332300.8FOXO_KO.1 4.8724 0.5316 100 1582.668 1581.667 -1.4 248796.6FOXO_KO.1 5.2475 0.4951 100 1868.815 1866.811 -1.6 155545.1FOXO_KO.1 3.6787 0.4374 100 1866.808 1866.811 -1.4 376317.9

* FOXO_KO.5 3.9314 0.328 100 2428.167 2427.164 -0.1 28208.1IPI:IPI00 4 16 21.40% 145 17258 10.6 U Tax_Id=10090 Gene_Symbol=Rpl26 60S ribosomal protein L26

FOXO_KO.1 2.6118 0.239 99.6 1082.525 1082.527 -1.1 327202.9FOXO_KO.1 2.9512 0.2233 99.8 1087.573 1087.574 -1.6 215080.4FOXO_KO_w 4.9906 0.2555 100 1613.79 1612.789 -1.4 66281.1FOXO_KO_w 3.541 0.2257 99.7 1613.793 1612.789 0.5 95148.8

IPI:IPI00 2 2 21.20% 165 17805 9.4 U Tax_Id=10090 Gene_Symbol=Rpl12 60S ribosomal protein L12 * FOXO_KO.1 4.5896 0.5691 100 1675.804 1675.807 -1.6 203303.7

FOXO_KO.1 4.3463 0.4458 100 2047.919 2046.919 -1.3 204660.3IPI:IPI00 3 3 21.10% 228 26779 5 U Tax_Id=10090 Gene_Symbol=2310003C23Rik Protein C20orf11 homolog * FOXO_KO.2 5.3869 0.4799 100 1920.889 1919.89 -2.6 269619.8* FOXO_KO.2 5.7284 0.4674 100 2622.243 2621.244 -1.7 118863* FOXO_KO.3 3.6288 0.2961 99.9 3386.515 3385.516 -1.2 48327.8IPI:IPI00 2 4 21.10% 199 22466 6.8 U Tax_Id=10090 Gene_Symbol=Glul 22 kDa protein

FOXO_KO.3 3.7369 0.252 99.7 3968.711 3966.704 -0.1 29026.9FOXO_KO_w 2.7103 0.261 99.8 1002.499 1002.5 -1.2 125998

IPI:IPI00 13 27 21.00% 951 108178 10.2 U Tax_Id=10090 Gene_Symbol=Thrap3 Thyroid hormone receptor-associated protein 3 FOXO_KO.9 5.3438 0.4361 100 3126.404 3124.405 -2.4 117083.4FOXO_KO_w 2.7762 0.2753 99.8 1011.45 1011.451 -1.1 42060.4FOXO_KO.9 4.7123 0.4829 100 3095.406 3094.4 0.7 81398.2FOXO_KO.1 3.9639 0.2881 99.9 1967.956 1966.972 -9.7 57769FOXO_KO_w 6.4794 0.4312 100 1987.893 1986.886 1.5 30426.2FOXO_KO_w 7.8936 0.4718 100 1986.887 1986.886 0.2 139568.6FOXO_KO.1 3.2287 0.2668 99.8 1446.682 1446.686 -2.5 238733.9FOXO_KO.1 3.325 0.349 99.9 1447.69 1446.686 0.1 278260FOXO_KO.1 5.2195 0.4599 100 1610.698 1610.7 -1.2 202007.6FOXO_KO.2 5.0151 0.3202 100 2150.011 2150.018 -3.3 232814.2

* FOXO_KO.1 3.8782 0.3107 100 1666.742 1665.739 0 257444.8* FOXO_KO.4 5.2138 0.4909 100 1683.722 1683.725 -1.7 31337.4

FOXO_KO.1 5.2974 0.4165 100 3184.208 3183.21 -1.7 44842.9IPI:IPI00 4 8 20.90% 206 23309 8 U Tax_Id=10090 Gene_Symbol=Actn4 23 kDa protein

FOXO_KO.1 3.2523 0.2534 99.9 1300.674 1299.669 1.1 28397.5FOXO_KO.2 5.3648 0.485 100 1903.943 1903.94 1.7 153546.3FOXO_KO.2 4.0242 0.273 99.9 1903.939 1903.94 -0.2 231426.3FOXO_KO.1 5.8741 0.438 100 1817.875 1816.875 -1.5 212571.5

IPI:IPI00 10 24 20.70% 709 80111 10.3 U Tax_Id=10090 Gene_Symbol=Thrap3 Thyroid hormone receptor associated protein 3 FOXO_KO.9 5.3438 0.4361 100 3126.404 3124.405 -2.4 117083.4FOXO_KO_w 2.7762 0.2753 99.8 1011.45 1011.451 -1.1 42060.4

FOXO_KO.9 4.7123 0.4829 100 3095.406 3094.4 0.7 81398.2FOXO_KO.1 3.9639 0.2881 99.9 1967.956 1966.972 -9.7 57769FOXO_KO_w 6.4794 0.4312 100 1987.893 1986.886 1.5 30426.2FOXO_KO_w 7.8936 0.4718 100 1986.887 1986.886 0.2 139568.6FOXO_KO.1 3.2287 0.2668 99.8 1446.682 1446.686 -2.5 238733.9FOXO_KO.1 3.325 0.349 99.9 1447.69 1446.686 0.1 278260FOXO_KO.1 5.2195 0.4599 100 1610.698 1610.7 -1.2 202007.6FOXO_KO.2 5.0151 0.3202 100 2150.011 2150.018 -3.3 232814.2

IPI:IPI00 1 1 20.70% 92 10574 9.6 U Tax_Id=10090 Gene_Symbol=Atp5j ATP synthase coupling factor VI FOXO_KO.1 4.2758 0.4415 100 2044.952 2044.957 -2.3 70766.7

IPI:IPI00 5 5 20.60% 155 17751 9.7 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc similar to ubiquitin/40S ribosomal protein S27a fusion protein isoform 2 IPI:IPI00 5 5 20.50% 156 17879 9.7 U Tax_Id=10090 Gene_Symbol=Gm8430 similar to fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a

FOXO_KO.1 6.0569 0.5383 100 2158.843 2157.842 -1.3 131944.5FOXO_KO.1 4.6764 0.452 100 1869.773 1868.769 0.1 73724.9FOXO_KO.1 2.7883 0.2672 99.5 1869.773 1868.769 0.4 848001.3FOXO_KO.1 4.7916 0.3189 100 1735.729 1734.728 -1.4 210784.1FOXO_KO.1 3.3115 0.2928 99.9 1734.727 1734.728 -0.6 447011.1

IPI:IPI00 12 16 20.40% 763 82670 9.1 U Tax_Id=10090 Gene_Symbol=Hadha Trifunctional enzyme subunit alpha, mitochondrial * FOXO_KO.4 4.2043 0.3842 99.9 3119.546 3119.547 -0.2 90857.9* FOXO_KO.4 6.714 0.5512 100 2451.167 2450.166 -0.8 108783.4* FOXO_KO.4 4.0706 0.2449 99.8 2451.151 2450.166 -7.1 121294.4* FOXO_KO.3 4.7773 0.5187 100 1626.846 1625.842 0.6 232068.4* FOXO_KO.1 6.4338 0.535 100 1724.814 1723.813 -1.4 191371.6* FOXO_KO.3 5.0367 0.3614 100 1613.828 1612.822 1.6 205117.6* FOXO_KO.3 5.2874 0.5091 100 2075.052 2074.049 -0.4 107371.4* FOXO_KO.4 4.4745 0.2724 100 1635.825 1635.83 -2.7 178756.1* FOXO_KO.5 6.5002 0.4895 100 3612.86 3611.859 -0.7 57042.8* FOXO_KO.3 5.1347 0.4633 100 3405.688 3403.68 0.4 98754.6* FOXO_KO.1 5.5578 0.4994 100 1833.905 1832.903 -0.4 157403.6* FOXO_KO.1 3.745 0.4175 100 1832.901 1832.903 -0.7 391789.2contamin 10 15 20.40% 653 72116 5.1 U owl|P11021| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN...

FOXO_KO.2 5.7379 0.4723 100 3076.489 3074.487 -1.5 93245.3FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.1 3.1757 0.3987 100 1566.778 1566.78 -0.9 273199.2FOXO_KO.1 5.3256 0.3394 100 1677.808 1677.808 -0.1 160962.8FOXO_KO.2 3.8378 0.3699 100 1512.751 1512.752 -0.4 150874.8FOXO_KO.2 6.5779 0.3968 100 2489.321 2488.314 1.5 55541FOXO_KO.2 3.4612 0.3777 99.9 1974.908 1974.908 0.1 285365.9FOXO_KO.2 8.4716 0.5582 100 2175.044 2174.04 0.3 208279.7FOXO_KO.2 3.9334 0.3146 99.9 2174.036 2174.04 -1.7 739911FOXO_KO.2 3.1931 0.3072 99.9 1397.789 1397.789 -0.1 165801.8

IPI:IPI00 2 4 20.30% 128 14759 9.2 U Tax_Id=10090 Gene_Symbol=Rpl22;mCG_130059 60S ribosomal protein L22 IPI:IPI006 2 5 18.60% 140 15990 10 U Tax_Id=10090 Gene_Symbol=Gm6784;LOC632026 similar to ribosomal protein L22

FOXO_KO.4 6.2481 0.4413 100 3085.395 3083.388 0.3 61132.3FOXO_KO.4 5.9924 0.501 100 3085.387 3083.388 -2.3 139847.4

IPI:IPI00 4 5 20.20% 243 26674 9.7 U Tax_Id=10090 Gene_Symbol=Rps3 40S ribosomal protein S3 FOXO_KO.1 2.3075 0.2913 99.7 1092.568 1092.568 -0.3 302582.8FOXO_KO.2 3.8121 0.5128 100 1572.755 1572.758 -2.3 156609.7

* FOXO_KO.2 3.6202 0.3729 99.9 2992.557 2990.549 0.5 155203.1* FOXO_KO.1 3.4279 0.3336 99.9 1470.766 1470.769 -1.5 2116742contamina 13 19 20.10% 643 65494 6.6 U no description

FOXO_KO.1 4.5895 0.3602 100 1475.782 1475.785 -2.1 241573.9* FOXO_KO.3 5.1788 0.4469 100 1994.978 1993.977 -1.2 116897.8* FOXO_KO.2 4.1092 0.3998 99.9 2591.168 2590.166 -0.4 140211.9

FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715FOXO_KO.1 3.3925 0.407 100 1265.638 1265.637 0.2 206086.8FOXO_KO.9 3.9854 0.4248 100 1393.729 1393.732 -2.2 150652.6

* FOXO_KO_w 2.5932 0.4501 100 999.4431 999.4451 -2 111851.2* FOXO_KO.1 6.3922 0.4303 100 2502.254 2501.252 -0.4 195473.1* FOXO_KO.1 5.626 0.4822 100 1717.852 1716.851 -1.7 316887.7* FOXO_KO.2 4.3379 0.389 100 1600.838 1599.834 0.4 206539.6* FOXO_KO.1 4.7111 0.3738 100 1357.694 1357.696 -1.4 247890.1

FOXO_KO.1 3.1193 0.3414 100 1142.524 1141.519 0.9 524535.2IPI:IPI00 7 9 20.10% 214 24604 10.1 U Tax_Id=10090 Gene_Symbol=Rpl10;LOC100048223;LOC100048462;Gm10041;Gm13891 60S ribosomal protein L10 IPI:IPI00 7 9 20.10% 214 24633 10 U Tax_Id=10090 Gene_Symbol=Rpl10 Putative uncharacterized protein IPI:IPI008 7 9 20.10% 214 24622 10 U Tax_Id=10090 Gene_Symbol=Gm3405 similar to QM protein IPI:IPI00 7 9 21.40% 201 23072 10 U Tax_Id=10090 Gene_Symbol=Rpl10 23 kDa protein

FOXO_KO.3 6.4864 0.4383 100 3281.533 3281.509 7.5 151646.7FOXO_KO.3 5.6295 0.3993 100 3083.379 3082.377 -0.5 52707.7FOXO_KO.3 5.0166 0.431 100 3084.378 3082.377 -1.8 134063.1FOXO_KO.3 3.3446 0.3291 99.9 3083.376 3082.377 -1.3 136302.4FOXO_KO.2 4.4751 0.3232 100 1544.658 1544.657 0.2 313072.4FOXO_KO.2 4.7291 0.5106 100 1700.757 1700.758 -1 520834.8FOXO_KO.2 3.5385 0.3471 99.9 1700.758 1700.758 -0.3 420597

IPI:IPI004 4 4 20.00% 275 30924 7.4 U Tax_Id=10090 Gene_Symbol=Myh9 Putative uncharacterized protein FOXO_KO.2 5.5851 0.4271 100 2288.117 2286.11 0.2 60350.5FOXO_KO.3 4.7338 0.4814 100 1728.86 1727.856 0.5 138900.4FOXO_KO.1 6.1563 0.4136 100 2300.998 2299.995 -0.2 59219.3FOXO_KO.1 3.8968 0.2869 99.9 2299.994 2299.995 -0.5 147665.5

IPI:IPI00 13 25 19.90% 800 87918 6.2 U Tax_Id=10090 Gene_Symbol=Hnrnpu Heterogeneous nuclear ribonucleoprotein U * FOXO_KO_w 3.2058 0.1918 99.8 1074.604 1074.604 -0.5 77295.2* FOXO_KO.1 5.1039 0.4316 100 2981.413 2980.418 -2.8 84142.9* FOXO_KO.1 3.6285 0.3968 100 1292.587 1291.584 -0.6 478302.9* FOXO_KO.1 4.5016 0.4206 100 1698.782 1697.781 -1 326278.9* FOXO_KO.1 3.5627 0.2949 99.9 1698.785 1697.781 0.6 229152* FOXO_KO.2 4.2024 0.4194 100 3916.659 3914.656 -1 23109.4* FOXO_KO.3 3.3141 0.2877 99.9 2708.31 2707.307 -0.3 27433.1* FOXO_KO.3 4.906 0.4225 100 2708.316 2707.307 2.2 222040* FOXO_KO.1 4.5831 0.3459 100 1647.841 1647.845 -2.5 213782.2* FOXO_KO.4 5.8494 0.5224 100 2603.244 2602.238 1 28211.9* FOXO_KO.4 3.7227 0.392 99.9 2602.242 2602.238 1.7 67799.8* FOXO_KO.4 4.7261 0.3387 100 3189.522 3187.514 0.3 36500.1* FOXO_KO_w 3.4435 0.2614 99.9 1266.656 1266.658 -1.3 75578.5IPI:IPI00 11 18 19.90% 662 73102 7.2 U Tax_Id=10090 Gene_Symbol=Ddx3x ATP-dependent RNA helicase DDX3X

FOXO_KO_w 3.2496 0.3302 99.9 1232.553 1232.554 -1.3 66452.2

* FOXO_KO.1 5.8305 0.4565 100 2349.032 2347.03 -2 109620.1FOXO_KO.1 4.0965 0.4435 100 1757.795 1757.798 -1.6 130057.5FOXO_KO.2 5.7021 0.5006 100 1882.918 1882.918 -0.2 85362.2FOXO_KO.1 3.3208 0.3056 99.9 1320.677 1320.679 -1.8 245487.9FOXO_KO.4 4.73 0.4418 100 1558.8 1557.795 1.2 162630.1FOXO_KO.2 6.8476 0.5182 100 2743.229 2741.226 -1.4 116040.4FOXO_KO.2 4.0987 0.3399 99.9 2742.226 2741.226 -1.3 144754.4FOXO_KO_w 3.4602 0.2204 99.9 1300.638 1300.639 -0.8 56139.4FOXO_KO.3 5.4304 0.5091 100 2084.028 2083.024 -0.1 146678.2FOXO_KO.3 3.3332 0.3399 100 1129.658 1128.651 2.9 337630.5

IPI:IPI00 5 6 19.90% 579 63846 9.3 U Tax_Id=10090 Gene_Symbol=Mtdh Protein LYRIC FOXO_KO.2 5.9659 0.5049 100 1804.808 1804.81 -1.1 129145.9

* FOXO_KO.1 5.0581 0.3366 99.9 2537.132 2535.149 -9.4 158401.2* FOXO_KO.9 3.9405 0.3032 99.9 2954.345 2952.347 -2.9 83344.6* FOXO_KO.1 4.0396 0.2929 99.9 3217.465 3215.457 0.3 48549.5* FOXO_KO.1 4.6413 0.3638 100 2246.023 2246.024 -0.8 69947IPI:IPI00 7 8 19.80% 620 70423 8.9 U Tax_Id=10090 Gene_Symbol=Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 * FOXO_KO.4 6.5434 0.5617 100 2165.214 2164.211 -0.4 128012.4

FOXO_KO.1 3.0114 0.2798 99.9 1142.585 1142.584 0.4 168602.8FOXO_KO.2 3.3681 0.252 99.5 2889.389 2888.391 -1.8 107912.1FOXO_KO.1 5.5336 0.5053 100 2171.005 2171.007 -1 53366.6FOXO_KO.5 4.5683 0.3937 99.9 3982.012 3981.003 1.3 21497.3FOXO_KO.5 4.9334 0.4591 100 3668.834 3666.829 -0.4 33345.3FOXO_KO.2 3.481 0.3986 100 1347.577 1347.577 -0.4 433511.6

IPI:IPI00 5 6 19.80% 248 28468 4.7 U Tax_Id=10090 Gene_Symbol=Tpm4 Tropomyosin alpha-4 chain * FOXO_KO.8 5.4217 0.4779 100 1728.848 1728.851 -2 104644.7* FOXO_KO.9 4.4328 0.3468 100 1600.758 1600.756 0.9 220950.4* FOXO_KO.2 3.6367 0.2208 99.9 1257.669 1257.669 0 224832.5* FOXO_KO.5 5.7862 0.3601 100 3126.608 3124.601 0.2 68612.3

FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9IPI:IPI00 1 1 19.70% 122 14467 9.4 U Tax_Id=10090 Gene_Symbol=Rpl22l1 Isoform 1 of 60S ribosomal protein L22-like 1 IPI:IPI007 1 1 19.80% 121 14339 9.4 U Tax_Id=10090 Gene_Symbol=Rpl22l1 Isoform 2 of 60S ribosomal protein L22-like 1

FOXO_KO.3 5.3652 0.2869 99.9 2834.353 2833.358 -2.8 61048.4IPI:IPI00 1 2 19.40% 129 15081 9.9 U Tax_Id=10090 Gene_Symbol=Ndufb4;Gm3244;Gm3873 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 IPI:IPI00 1 2 21.00% 119 13108 9.8 U Tax_Id=10090 Gene_Symbol=Ndufb4 Putative uncharacterized protein

FOXO_KO.2 4.4384 0.3977 99.9 2732.393 2731.383 2.6 143277.7IPI:IPI00 1 1 19.40% 103 11956 5.9 U Tax_Id=10090 Gene_Symbol=Mycbp C-Myc-binding protein IPI:IPI00 1 1 19.40% 103 11970 5.9 U Tax_Id=10090 Gene_Symbol=Mycbp Putative uncharacterized protein IPI:IPI00 1 1 13.70% 146 16614 9.1 U Tax_Id=10090 Gene_Symbol=Mycbp C-myc binding protein

FOXO_KO.3 3.8844 0.4351 100 2263.227 2262.227 -1.5 190562.5IPI:IPI00 11 21 19.30% 379 39652 9 U Tax_Id=10090 Gene_Symbol=Hnrnpa3 Isoform 1 of Heterogeneous nuclear ribonucleoprotein A3 IPI:IPI00 11 21 23.30% 313 33200 8.7 U Tax_Id=10090 Gene_Symbol=- similar to heterogeneous nuclear ribonucleoprotein A3 IPI:IPI00 11 21 22.90% 319 33723 7.5 U Tax_Id=10090 Gene_Symbol=Gm5469 similar to heterogeneous nuclear ribonucleoprotein A3 IPI:IPI00 11 21 23.50% 310 32957 8.5 U Tax_Id=10090 Gene_Symbol=Gm9242 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1 IPI:IPI007 11 21 26.10% 280 30451 8.7 U Tax_Id=10090 Gene_Symbol=Gm11847 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 13 IPI:IPI00 11 21 21.90% 333 34991 8.7 U Tax_Id=10090 Gene_Symbol=Gm9242 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 3 IPI:IPI00 11 21 20.40% 357 37140 8.3 U Tax_Id=10090 Gene_Symbol=Gm9242 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 4 IPI:IPI006 11 21 23.90% 306 33215 5.9 U Tax_Id=10090 Gene_Symbol=- similar to heterogeneous nuclear ribonucleoprotein A3, isoform 2

IPI:IPI00 11 21 23.00% 317 34226 8.8 U Tax_Id=10090 Gene_Symbol=Gm11847 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 12 IPI:IPI006 11 21 24.70% 296 31882 8.1 U Tax_Id=10090 Gene_Symbol=Gm6793 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1 IPI:IPI006 11 21 22.70% 322 34176 8.5 U Tax_Id=10090 Gene_Symbol=Gm5469 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 7 IPI:IPI00 11 21 20.80% 351 36610 8.1 U Tax_Id=10090 Gene_Symbol=Gm6793 EG627828 protein IPI:IPI006 11 21 20.90% 350 36540 8.3 U Tax_Id=10090 Gene_Symbol=Gm11847 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 16 IPI:IPI00 11 21 24.00% 304 32912 9.2 U Tax_Id=10090 Gene_Symbol=- 33 kDa protein IPI:IPI004 11 21 20.40% 357 37242 8.6 U Tax_Id=10090 Gene_Symbol=Gm5469 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1 IPI:IPI00 11 21 23.00% 318 34476 9.1 U Tax_Id=10090 Gene_Symbol=Hnrnpa3 Heterogeneous nuclear ribonucleoprotein A3 IPI:IPI00 11 21 20.40% 357 37086 8.3 U Tax_Id=10090 Gene_Symbol=Hnrnpa3 Isoform 2 of Heterogeneous nuclear ribonucleoprotein A3

FOXO_KO.2 5.0963 0.312 99.9 2570.292 2569.293 -1.8 77274FOXO_KO.3 6.337 0.49 100 2441.196 2441.198 -1 116799.3FOXO_KO.1 4.1594 0.4475 100 2011.045 2011.049 -2.2 158715FOXO_KO.1 6.4666 0.4741 100 1883.959 1882.955 0.4 125362.6FOXO_KO.2 5.5295 0.3827 100 2565.255 2565.251 1.6 267661.5FOXO_KO.1 4.1873 0.4477 100 1582.777 1582.778 -0.8 226391.8FOXO_KO.1 3.393 0.3538 100 1234.596 1234.598 -1.9 299622.8FOXO_KO.2 3.7799 0.3821 100 1869.875 1869.877 -0.7 125442.9FOXO_KO.2 4.3631 0.3994 100 1869.874 1869.877 -1.3 298207.1FOXO_KO.2 5.5601 0.4986 100 1713.773 1713.776 -1.8 660872.2FOXO_KO.2 2.8561 0.3168 99.8 1713.774 1713.776 -0.9 248223.5

IPI:IPI00 1 1 19.30% 145 16017 10.4 U Tax_Id=10090 Gene_Symbol=Rps23 Putative uncharacterized protein IPI:IPI00 1 1 19.60% 143 15808 10.5 U Tax_Id=10090 Gene_Symbol=LOC100046668;Rps23;Gm15450 40S ribosomal protein S23

FOXO_KO.3 4.3917 0.2577 99.9 3125.546 3124.541 0.6 109625.4IPI:IPI006 5 9 19.20% 208 24225 10.3 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein S8 isoform 1

FOXO_KO.1 3.3225 0.2386 99.8 1316.686 1314.679 0.7 307943.8FOXO_KO.1 4.4379 0.4429 100 1507.782 1506.78 -1 275448.3FOXO_KO.2 3.1759 0.3679 100 951.4775 951.4782 -0.7 50659FOXO_KO.2 5.2134 0.452 100 1902.967 1901.964 -0.2 200691.8FOXO_KO.2 4.5106 0.417 100 1901.965 1901.964 0.1 261497

IPI:IPI00 5 9 19.20% 208 24171 10.3 U Tax_Id=10090 Gene_Symbol=Gm5121 similar to ribosomal protein S8 isoform 1 FOXO_KO.1 3.3225 0.2386 99.8 1316.686 1314.679 0.7 307943.8FOXO_KO.1 4.4379 0.4429 100 1507.782 1506.78 -1 275448.3FOXO_KO.2 3.1759 0.3679 100 951.4775 951.4782 -0.7 50659FOXO_KO.2 5.2134 0.452 100 1902.967 1901.964 -0.2 200691.8FOXO_KO.2 4.5106 0.417 100 1901.965 1901.964 0.1 261497

IPI:IPI00 1 1 19.20% 172 19796 5 U Tax_Id=10090 Gene_Symbol=Cetn2 Centrin-2 IPI:IPI00 1 1 20.20% 163 18787 4.9 U Tax_Id=10090 Gene_Symbol=Cetn2 19 kDa protein

FOXO_KO.3 4.1906 0.3715 99.9 3838.694 3837.688 0.7 25747.4IPI:IPI00 2 3 19.10% 194 22085 10.1 U Tax_Id=10090 Gene_Symbol=Gm6472;LOC634044 similar to ribosomal protein S7 isoform 1 IPI:IPI00 2 3 22.70% 163 18735 10.4 U Tax_Id=10090 Gene_Symbol=Gm9493 similar to ribosomal protein S7

FOXO_KO.3 7.0584 0.5906 100 2368.281 2367.281 -1.1 140947.3FOXO_KO.3 2.7297 0.3174 99.8 1783.89 1783.89 -0.2 148761.4

IPI:IPI00 5 17 19.10% 152 17363 7.5 U Tax_Id=10090 Gene_Symbol=Nme2 Nucleoside diphosphate kinase B FOXO_KO_w 4.4515 0.2587 99.9 1485.716 1485.718 -1.3 41140.6FOXO_KO_w 3.1136 0.38 99.9 1485.721 1485.718 1.9 49955.6

* FOXO_KO.3 5.807 0.4324 100 3428.729 3426.721 0.3 69931.5* FOXO_KO.3 4.0884 0.4402 100 3427.725 3426.721 0 114102.1* FOXO_KO.3 2.8355 0.264 99.5 1960.024 1960.022 1.1 322665.1

IPI:IPI00 2 3 19.10% 115 12230 4.9 U Tax_Id=10090 Gene_Symbol=Zc3hav1 Putative uncharacterized protein FOXO_KO.5 4.081 0.2846 99.9 2534.36 2532.352 0.7 26596.9FOXO_KO.5 3.8985 0.2742 99.9 2533.351 2532.352 -1.6 60093.9

IPI:IPI00 3 5 19.00% 315 37064 4.7 U Tax_Id=10090 Gene_Symbol=Calu Calumenin FOXO_KO.1 3.7733 0.4242 99.9 2507.086 2506.091 -3.1 152285.7

* FOXO_KO.1 5.0927 0.4563 100 1708.825 1708.828 -1.4 203020.7FOXO_KO.1 4.948 0.3156 99.9 2751.249 2749.241 0.5 83129.5

IPI:IPI00 3 4 18.80% 208 24235 10.3 U Tax_Id=10090 Gene_Symbol=Gm11353 Ribosomal protein S8 IPI:IPI00 3 4 18.80% 208 24263 10.3 U Tax_Id=10090 Gene_Symbol=Rps8 Ribosomal protein S8

FOXO_KO.2 4.9554 0.4491 100 1788.748 1787.748 -1.4 548899FOXO_KO.1 3.3225 0.2386 99.8 1316.686 1314.679 0.7 307943.8FOXO_KO.1 4.4379 0.4429 100 1507.782 1506.78 -1 275448.3

IPI:IPI00 7 10 18.70% 434 47141 6.8 U Tax_Id=10090 Gene_Symbol=Eno1;LOC100044223;Gm5506 Alpha-enolase IPI:IPI00 7 10 22.10% 366 39782 6.2 U Tax_Id=10090 Gene_Symbol=Eno1 Enolase

FOXO_KO.1 3.7412 0.4086 100 1280.584 1280.586 -2 228053.6FOXO_KO.3 5.3816 0.527 100 3106.583 3105.574 1.9 109406.4FOXO_KO.2 5.8971 0.4147 100 1962.927 1960.925 -2.3 185038.2FOXO_KO.1 5.608 0.4777 100 1827.857 1826.856 -1.2 91196.8FOXO_KO.1 3.3198 0.3396 99.9 1827.857 1826.856 -1 309743.2FOXO_KO.3 4.764 0.3637 100 2971.364 2970.358 0.9 26005.3FOXO_KO.3 3.9999 0.278 99.9 2971.364 2970.358 0.7 53113.8

IPI:IPI00 1 1 18.60% 156 18267 9.1 U Tax_Id=10090 Gene_Symbol=Mina Putative uncharacterized protein IPI:IPI00 1 1 7.80% 373 42730 6.8 U Tax_Id=10090 Gene_Symbol=Mina 43 kDa protein IPI:IPI00 1 1 39.20% 74 8511 4.7 U Tax_Id=10090 Gene_Symbol=Mina 9 kDa protein

FOXO_KO.4 6.4115 0.4526 100 3254.701 3252.693 0.6 86528.6IPI:IPI008 8 22 18.50% 439 48511 5.9 U Tax_Id=10090 Gene_Symbol=Hnrnpk Isoform 3 of Heterogeneous nuclear ribonucleoprotein K

FOXO_KO.9 5.3147 0.4099 100 1579.703 1579.706 -1.8 225521.2FOXO_KO.8 4.7697 0.4788 100 1735.801 1735.807 -3.4 139915FOXO_KO.8 4.1325 0.2851 99.9 1735.801 1735.807 -3.4 1996603FOXO_KO.1 4.9431 0.4986 100 1781.802 1780.798 0 325850.2FOXO_KO_w 2.3743 0.2836 99.8 998.386 998.3884 -2.4 72628.7FOXO_KO.1 6.3971 0.5799 100 2068.976 2068.978 -0.8 63290.2FOXO_KO.1 3.8455 0.3934 100 1259.573 1259.575 -1.4 309421.7FOXO_KO.3 4.6939 0.4545 100 3830.95 3829.945 0.4 66726.4

IPI:IPI00 5 5 18.50% 259 30022 5.5 U Tax_Id=10090 Gene_Symbol=Cltc Clathrin, heavy polypeptide FOXO_KO.3 5.5726 0.4328 100 2356.15 2355.146 0.2 90431.6FOXO_KO.4 5.519 0.4182 100 3389.613 3387.605 0.3 66911.9FOXO_KO.5 4.9122 0.4203 100 2121.039 2121.039 0.3 98810.4FOXO_KO.5 5.3997 0.4896 100 2122.047 2121.039 2.3 106149.7FOXO_KO.4 3.944 0.4115 100 2277.145 2277.14 2.5 74223.4

IPI:IPI00 3 3 18.40% 152 17319 9.9 U Tax_Id=10090 Gene_Symbol=Ssbp1 Single-stranded DNA-binding protein, mitochondrial IPI:IPI00 3 3 18.90% 148 17157 9.8 U Tax_Id=10090 Gene_Symbol=Ssbp1 single-stranded DNA binding protein 1 isoform 1

FOXO_KO.1 4.9754 0.4779 100 1629.704 1629.706 -1.6 185370.6FOXO_KO.1 2.297 0.3131 99.8 1119.468 1119.466 1.6 202084.8FOXO_KO.1 4.0064 0.4408 100 1604.725 1602.722 -1.9 514198.4

IPI:IPI00 7 11 18.30% 529 56301 5.3 U Tax_Id=10090 Gene_Symbol=Atp5b ATP synthase subunit beta, mitochondrial * FOXO_KO.1 3.3326 0.2811 99.9 1385.708 1385.709 -1.1 247469.6* FOXO_KO.4 3.6868 0.3581 99.9 3026.556 3026.554 0.5 67694.2

* FOXO_KO.3 4.823 0.3811 100 2060.996 2060.996 0.4 91927.1* FOXO_KO.5 6.2792 0.5055 100 1921.966 1921.966 0.1 514359.8* FOXO_KO.5 4.6731 0.462 100 1921.967 1921.966 0.6 110052.9* FOXO_KO.4 5.9748 0.4723 100 2676.384 2675.381 -0.1 81352.8* FOXO_KO.4 5.0389 0.3477 99.9 2677.392 2675.381 1.7 134380.2IPI:IPI00 2 4 18.30% 268 30603 7.3 U Tax_Id=10090 Gene_Symbol=Mettl1 tRNA (guanine-N(7)-)-methyltransferase

FOXO_KO.4 4.4686 0.3184 99.9 3072.492 3070.491 -1.6 88587.2* FOXO_KO.2 5.4241 0.4707 100 2623.312 2622.315 -2.2 288550.6IPI:IPI00 6 10 18.20% 412 46585 8.2 U Tax_Id=10090 Gene_Symbol=- 47 kDa protein

FOXO_KO.3 5.8473 0.549 100 2659.273 2658.268 0.6 77937.7FOXO_KO.3 3.4512 0.4589 99.9 2658.269 2658.268 0.2 181683FOXO_KO.4 4.2195 0.3817 99.9 3461.731 3460.731 -0.8 90324.7FOXO_KO.3 5.4006 0.5112 100 2416.15 2415.15 -1.7 86668.6FOXO_KO.3 4.24 0.4625 100 2416.16 2415.15 2.8 153058.4FOXO_KO.3 4.4394 0.3407 99.9 2661.242 2661.232 3.8 121055.7

IPI:IPI00 2 3 18.20% 181 20478 6 U Tax_Id=10090 Gene_Symbol=Arf4 Putative uncharacterized protein IPI:IPI00 2 3 18.20% 181 20466 7.2 U Tax_Id=10090 Gene_Symbol=Arf4 20 kDa protein

FOXO_KO.5 6.4238 0.4914 100 2076.114 2075.109 0.6 91089.5FOXO_KO.2 4.6854 0.3236 100 1664.77 1663.767 -0.2 162473.4

IPI:IPI004 8 11 18.10% 464 53786 7 U Tax_Id=10090 Gene_Symbol=Stk38l Isoform 1 of Serine/threonine-protein kinase 38-like IPI:IPI00 8 11 17.80% 471 54610 7 U Tax_Id=10090 Gene_Symbol=Stk38l Serine/threonine kinase 38 like IPI:IPI00 8 11 18.10% 464 53772 7 U Tax_Id=10090 Gene_Symbol=Stk38l MCG15023 IPI:IPI005 8 11 17.80% 471 54624 7 U Tax_Id=10090 Gene_Symbol=Stk38l Isoform 2 of Serine/threonine-protein kinase 38-like

FOXO_KO.1 6.9438 0.4886 100 1820.864 1819.863 -1 211223.6FOXO_KO.1 4.8137 0.3184 99.9 1949.963 1947.958 -0.8 732171.6FOXO_KO.1 5.7958 0.4343 100 1691.766 1691.768 -1.2 237784.4FOXO_KO.2 3.4678 0.3525 100 1136.584 1136.583 0.6 137864.8FOXO_KO.4 7.256 0.4075 100 3618.849 3617.849 -0.9 46339.4FOXO_KO.5 3.9145 0.228 99.5 3491.759 3489.754 -0.4 148707.2FOXO_KO.3 5.0147 0.4784 100 3030.419 3029.411 1.4 138081.3FOXO_KO.3 3.0302 0.2693 99.8 2874.315 2873.31 0.3 7646

IPI:IPI009 5 6 18.10% 364 41491 5.5 U Tax_Id=10090 Gene_Symbol=Eif4a1 eukaryotic translation initiation factor 4A1 isoform 2 FOXO_KO.5 4.9107 0.4904 100 4167.862 4166.856 0.8 10920.2FOXO_KO.3 5.1986 0.4433 100 1556.713 1555.713 -2.4 332300.8FOXO_KO.1 4.8724 0.5316 100 1582.668 1581.667 -1.4 248796.6FOXO_KO.1 5.2475 0.4951 100 1868.815 1866.811 -1.6 155545.1FOXO_KO.1 3.6787 0.4374 100 1866.808 1866.811 -1.4 376317.9

IPI:IPI00 3 3 18.10% 260 29366 7.4 U Tax_Id=10090 Gene_Symbol=Car3 Carbonic anhydrase 3 * FOXO_KO.2 2.9292 0.2992 99.8 1338.665 1338.665 0.5 24812.3* FOXO_KO.1 3.4659 0.3731 99.9 2299.096 2299.099 -1.3 163149.1* FOXO_KO.3 4.3227 0.3719 100 1618.866 1618.869 -1.6 242642.4contamina 7 11 17.90% 357 39219 5.2 U no description* FOXO_KO.2 3.3358 0.3153 99.9 2471.187 2471.187 -0.2 167371.6

FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715FOXO_KO.4 7.2782 0.5489 100 2419.256 2418.251 0.5 125973.8FOXO_KO.4 5.169 0.4402 100 2420.264 2418.251 2.7 168871.3FOXO_KO_w 3.5977 0.3299 100 1315.697 1315.696 0.6 55449.6

FOXO_KO.1 3.5055 0.2416 99.8 1357.732 1357.732 -0.4 213307.3IPI:IPI00 1 2 17.90% 179 20110 8.4 U Tax_Id=10090 Gene_Symbol=Opa3 Optic atrophy 3 protein homolog * FOXO_KO.4 4.4452 0.4338 100 3520.867 3520.868 -0.3 70841.7IPI:IPI001 2 2 17.80% 236 26021 4.1 U Tax_Id=10090 Gene_Symbol=Clns1a Methylosome subunit pICln

FOXO_KO.1 3.0422 0.3218 99.9 1989.965 1988.954 4.2 97306.1FOXO_KO.2 4.2776 0.5161 100 2770.148 2769.147 -0.6 41642.5

IPI:IPI00 1 1 17.80% 152 15485 4.9 U Tax_Id=10090 Gene_Symbol=Eif2ak3 15 kDa protein FOXO_KO.2 4.2404 0.2584 99.9 2651.328 2650.321 1.7 93012.7

IPI:IPI00 4 4 17.70% 412 45746 6.5 U Tax_Id=10090 Gene_Symbol=Dnaja2 DnaJ homolog subfamily A member 2 * FOXO_KO.3 4.5069 0.4627 100 2640.377 2640.377 0.3 39318* FOXO_KO.3 4.497 0.3952 99.9 2641.379 2640.377 -0.3 177247.2* FOXO_KO.3 3.6182 0.3252 99.9 1862.868 1862.871 -1.4 126005.8* FOXO_KO.4 5.2404 0.4549 100 3770.874 3769.866 1.4 41344.5IPI:IPI00 3 4 17.70% 390 43232 8.2 U Tax_Id=10090 Gene_Symbol=Pdha1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial * FOXO_KO.9 3.0632 0.3231 99.9 1753.624 1752.624 -1.7 167950.9* FOXO_KO.2 6.3882 0.4905 100 2275.167 2274.165 -0.4 118050.4* FOXO_KO.3 4.028 0.3561 99.9 3962.887 3960.881 -0.4 22872.4IPI:IPI00 6 23 17.70% 355 40520 10.3 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 2 IPI:IPI00 6 23 17.70% 355 40528 10.3 U Tax_Id=10090 Gene_Symbol=Gm16468 similar to ribosomal protein L3 isoform 2

FOXO_KO.2 5.4225 0.5099 100 1763.922 1761.917 -0.8 418329.8FOXO_KO.2 3.5993 0.3585 99.9 1761.915 1761.917 -1.4 549226.4FOXO_KO.8 4.2119 0.4213 100 1592.751 1591.753 -3.4 108081FOXO_KO_w 2.8484 0.3534 100 1342.574 1342.576 -1 10932.4FOXO_KO_w 4.0559 0.4968 100 1342.575 1342.576 -0.9 293345.8FOXO_KO.3 4.4614 0.3649 99.9 3776.813 3774.796 2.7 17939.6

IPI:IPI003 5 8 17.70% 361 38814 9.7 U Tax_Id=10090 Gene_Symbol=Csda Isoform 1 of DNA-binding protein A IPI:IPI00 5 8 23.40% 274 29314 10.1 U Tax_Id=10090 Gene_Symbol=Csda Y-box binding protein (Fragment)

FOXO_KO.2 6.2205 0.4505 100 1796.825 1795.823 -1 263572.8FOXO_KO.2 5.0578 0.4115 100 3561.68 3559.667 1.7 50205.9FOXO_KO.1 5.7631 0.4831 100 1782.86 1782.862 -0.8 114277.8FOXO_KO.8 4.5118 0.5386 100 2914.396 2913.42 -9.4 40163.2FOXO_KO.9 5.3901 0.4649 100 2662.247 2660.266 -9.7 194787.4

IPI:IPI00 8 22 17.60% 459 51063 5.9 U Tax_Id=10090 Gene_Symbol=Hnrnpk Putative uncharacterized protein FOXO_KO.9 5.3147 0.4099 100 1579.703 1579.706 -1.8 225521.2FOXO_KO.8 4.7697 0.4788 100 1735.801 1735.807 -3.4 139915FOXO_KO.8 4.1325 0.2851 99.9 1735.801 1735.807 -3.4 1996603FOXO_KO.1 4.9431 0.4986 100 1781.802 1780.798 0 325850.2FOXO_KO_w 2.3743 0.2836 99.8 998.386 998.3884 -2.4 72628.7FOXO_KO.1 6.3971 0.5799 100 2068.976 2068.978 -0.8 63290.2FOXO_KO.1 3.8455 0.3934 100 1259.573 1259.575 -1.4 309421.7FOXO_KO.3 4.6939 0.4545 100 3830.95 3829.945 0.4 66726.4

IPI:IPI00 6 11 17.60% 210 23609 7.8 U Tax_Id=10090 Gene_Symbol=Gstp1 Glutathione S-transferase P 1 FOXO_KO.2 5.2709 0.4857 100 1854.921 1854.923 -1 73481.5FOXO_KO.2 5.3116 0.3368 100 1855.929 1854.923 1.1 158306.3

* FOXO_KO.1 5.1328 0.3987 100 2378.108 2376.103 -0.8 196827.3* FOXO_KO.2 5.595 0.447 100 1794.791 1792.784 -0.1 454111.6* FOXO_KO.2 5.1805 0.3075 99.9 1793.785 1792.784 -1.1 303527.1* FOXO_KO.1 5.3117 0.4508 100 1978.903 1977.9 -0.3 159703

IPI:IPI00 1 33 17.60% 188 20612 9.7 U Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 IPI:IPI00 1 33 19.30% 171 18704 9.7 U Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 IPI:IPI00 1 33 11.10% 297 32771 9.1 U Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase gamma chain

FOXO_KO.5 6.2445 0.369 100 3648.839 3646.832 0.3 29439IPI:IPI001 2 3 17.50% 217 24916 10 U Tax_Id=10090 Gene_Symbol=Rpl10a 60S ribosomal protein L10a

FOXO_KO.3 3.4929 0.3214 99.9 1900.969 1899.967 -0.7 141350.8FOXO_KO.6 5.3958 0.5076 100 2548.356 2547.353 -0.1 125017.7

IPI:IPI00 1 1 17.50% 63 7422 8.5 U Tax_Id=10090 Gene_Symbol=D10Wsu52e 7 kDa protein FOXO_KO.2 3.4856 0.3486 100 1399.657 1398.654 -0.2 130925.4

IPI:IPI00 6 7 17.40% 339 38676 7.7 U Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2 IPI:IPI00 6 7 21.70% 272 31263 8.3 U Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2

FOXO_KO.2 5.1619 0.3489 100 1812.869 1811.866 0.1 286947.7FOXO_KO.2 3.2203 0.386 99.9 1811.867 1811.866 0.8 156617.8FOXO_KO.2 3.41 0.2378 99.8 1939.954 1939.961 -3.6 118465.2FOXO_KO.2 5.5544 0.389 100 2065.986 2064.983 -0.3 118008.7FOXO_KO.2 5.0381 0.3067 99.9 2065.985 2064.983 -0.6 562348.2FOXO_KO.4 3.7436 0.2669 99.7 2838.427 2838.424 1 118792.6

IPI:IPI00 4 6 17.40% 247 27510 8.2 U Tax_Id=10090 Gene_Symbol=Psma2 Proteasome subunit alpha type IPI:IPI008 4 6 18.40% 234 25926 8.3 U Tax_Id=10090 Gene_Symbol=Psma2 Proteasome subunit alpha type-2

FOXO_KO.3 6.2241 0.4672 100 2358.238 2357.235 0.1 149875FOXO_KO.4 7.4595 0.5678 100 2202.132 2201.134 -2.1 149460.8FOXO_KO.4 5.1359 0.3952 100 2202.137 2201.134 0.1 246738.9FOXO_KO.2 5.9751 0.4452 100 2634.137 2632.129 0.3 33987.8

IPI:IPI00 6 13 17.30% 249 28566 10.7 U Tax_Id=10090 Gene_Symbol=- 29 kDa protein IPI:IPI00 6 13 17.30% 249 28681 10.8 U Tax_Id=10090 Gene_Symbol=Rps6;Gm13654 40S ribosomal protein S6

FOXO_KO.7 3.1571 0.1819 99.8 988.4929 988.4945 -1.6 106240.6FOXO_KO_w 2.1223 0.4616 99.9 1116.589 1116.59 -0.1 111205.1FOXO_KO.1 3.3956 0.2582 99.9 1463.782 1463.785 -2.2 196750.6FOXO_KO.1 3.32 0.2436 99.8 1335.691 1335.69 0.5 344081.9FOXO_KO.1 4.1138 0.3652 100 1280.647 1280.648 -0.6 33738FOXO_KO_w 2.5574 0.3274 99.8 1365.627 1365.629 -1.5 68875.6

IPI:IPI00 1 1 17.30% 81 8972 7.2 U Tax_Id=10090 Gene_Symbol=Nedd8 NEDD8 * FOXO_KO.1 3.5959 0.292 99.9 1685.857 1685.859 -1.4 234976.7IPI:IPI00 1 1 17.20% 163 18672 4.5 U Tax_Id=10090 Gene_Symbol=Skp1a S-phase kinase-associated protein 1 * FOXO_KO.3 3.0313 0.3454 99.9 2998.415 2997.407 1.5 14709IPI:IPI00 1 1 17.20% 58 6855 9.2 U Tax_Id=10090 Gene_Symbol=2900073G15Rik 7 kDa protein

FOXO_KO.1 2.9561 0.3844 100 1237.56 1237.563 -2.5 232629.8IPI:IPI00 9 16 17.10% 660 73141 7.2 U Tax_Id=10090 Gene_Symbol=D1Pas1 Putative ATP-dependent RNA helicase Pl10

FOXO_KO_w 3.2496 0.3302 99.9 1232.553 1232.554 -1.3 66452.2FOXO_KO.2 5.7021 0.5006 100 1882.918 1882.918 -0.2 85362.2FOXO_KO.1 3.3208 0.3056 99.9 1320.677 1320.679 -1.8 245487.9FOXO_KO.4 4.73 0.4418 100 1558.8 1557.795 1.2 162630.1FOXO_KO.2 6.8476 0.5182 100 2743.229 2741.226 -1.4 116040.4FOXO_KO.2 4.0987 0.3399 99.9 2742.226 2741.226 -1.3 144754.4FOXO_KO_w 3.4602 0.2204 99.9 1300.638 1300.639 -0.8 56139.4FOXO_KO.3 5.4304 0.5091 100 2084.028 2083.024 -0.1 146678.2FOXO_KO.3 3.3332 0.3399 100 1129.658 1128.651 2.9 337630.5

IPI:IPI00 1 1 17.10% 76 8469 10.1 U Tax_Id=10090 Gene_Symbol=Cox6c Cytochrome c oxidase subunit 6C

IPI:IPI00 1 1 17.10% 76 8684 10 U Tax_Id=10090 Gene_Symbol=Gm6265 hypothetical protein FOXO_KO.1 3.6676 0.1624 99.6 1693.736 1692.736 -2.1 166904.1

IPI:IPI003 4 5 17.00% 530 60699 8.2 U Tax_Id=10090 Gene_Symbol=Psmd3 26S proteasome non-ATPase regulatory subunit 3 IPI:IPI00 4 5 17.00% 530 60718 8.4 U Tax_Id=10090 Gene_Symbol=Psmd3 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3, isoform CRA_b

FOXO_KO.1 4.8743 0.4462 100 3700.709 3699.708 -0.6 21573.7FOXO_KO.2 4.7004 0.4203 100 1797.938 1796.939 -2.1 421261FOXO_KO.4 3.0975 0.3098 99.9 2679.315 2679.312 1 38046.1FOXO_KO.2 5.1337 0.4706 100 1674.859 1674.859 0.5 108818.7

IPI:IPI001 5 7 17.00% 418 47281 5.3 U Tax_Id=10090 Gene_Symbol=Psmc4 26S protease regulatory subunit 6B IPI:IPI00 5 7 17.00% 418 47408 5.2 U Tax_Id=10090 Gene_Symbol=Psmc4 proteasome 26S ATPase subunit 4

FOXO_KO.3 6.2012 0.4474 100 3673.847 3671.844 -1 64567.6FOXO_KO.3 6.2554 0.4162 100 2539.263 2538.261 -0.7 104502.5FOXO_KO.3 4.3528 0.3921 99.9 2538.259 2538.261 -0.9 215180FOXO_KO.2 5.015 0.4338 100 2123.001 2122.996 2.1 106733.7FOXO_KO.2 3.3106 0.3241 99.9 2122.998 2122.996 1 117198.6

IPI:IPI00 2 2 17.00% 200 22324 7 U Tax_Id=10090 Gene_Symbol=Myh9 Putative uncharacterized protein IPI:IPI00 2 2 14.50% 235 26347 5.6 U Tax_Id=10090 Gene_Symbol=Myh9 Myh9 protein

FOXO_KO.2 5.5851 0.4271 100 2288.117 2286.11 0.2 60350.5FOXO_KO.3 4.7338 0.4814 100 1728.86 1727.856 0.5 138900.4

IPI:IPI00 2 2 17.00% 112 12742 10.3 U Tax_Id=10090 Gene_Symbol=Prdx4 Putative uncharacterized protein FOXO_KO.1 6.0537 0.4473 100 2171.926 2170.925 -0.8 98177.2FOXO_KO.1 3.4648 0.3405 99.9 2170.919 2170.925 -2.5 208555.3

IPI:IPI00 4 7 16.90% 415 47756 9.8 U Tax_Id=10090 Gene_Symbol=Ssb Lupus La protein homolog IPI:IPI00 4 7 18.40% 381 43870 9.8 U Tax_Id=10090 Gene_Symbol=Ssb 44 kDa protein IPI:IPI00 4 7 18.40% 381 43891 9.8 U Tax_Id=10090 Gene_Symbol=Ssb Putative uncharacterized protein

FOXO_KO.1 5.3341 0.4309 100 2075.047 2074.045 -0.8 54881.1FOXO_KO.3 6.1201 0.4829 100 2081.008 2078.992 4.5 96574.6FOXO_KO.4 5.7128 0.4729 100 3134.563 3132.567 -3.4 58719.7FOXO_KO.2 5.0419 0.4459 100 2981.356 2980.353 -0.3 78735.9

IPI:IPI00 1 2 16.90% 160 18721 4.5 U Tax_Id=10090 Gene_Symbol=Ptges3;Gm9769;LOC100048119 Prostaglandin E synthase 3 * FOXO_KO.4 6.6989 0.5265 100 3474.377 3472.374 -0.8 75366IPI:IPI00 1 1 16.90% 83 9141 8.5 U Tax_Id=10090 Gene_Symbol=Rps21 40S ribosomal protein S21 * FOXO_KO.1 4.7341 0.4343 100 1584.74 1584.744 -2 327190.2IPI:IPI00 8 14 16.80% 518 59898 6 U Tax_Id=10090 Gene_Symbol=Actn4 Alpha-actinin

FOXO_KO.2 3.1976 0.2807 99.7 1921.929 1920.93 -2.2 135718FOXO_KO.1 3.2523 0.2534 99.9 1300.674 1299.669 1.1 28397.5FOXO_KO.2 5.3648 0.485 100 1903.943 1903.94 1.7 153546.3FOXO_KO.2 4.0242 0.273 99.9 1903.939 1903.94 -0.2 231426.3FOXO_KO.1 6.9508 0.535 100 2089.968 2088.966 -0.6 133572.6FOXO_KO.1 3.1331 0.248 99.5 2089.968 2088.966 -0.6 153705.8FOXO_KO.1 2.8954 0.2981 99.9 1255.605 1255.605 -0.4 325987.6FOXO_KO_w 6.4706 0.575 100 1754.827 1753.825 -0.7 24820.2

IPI:IPI00 5 6 16.80% 482 55075 5.5 U Tax_Id=10090 Gene_Symbol=Hdac1 Histone deacetylase 1 IPI:IPI00 5 6 17.90% 453 51312 5.1 U Tax_Id=10090 Gene_Symbol=LOC100046039 similar to histone deacetylase HD1

FOXO_KO.6 6.7864 0.5791 100 2355.238 2354.231 1.6 45425FOXO_KO.3 4.8936 0.4291 100 3184.534 3183.534 -1.1 85518.4FOXO_KO.2 5.7268 0.4282 100 2044.961 2043.958 0 149787FOXO_KO.2 3.4873 0.3279 99.9 2044.963 2043.958 0.7 102145.6

FOXO_KO.2 4.7077 0.4216 100 3727.594 3725.598 -3 32301IPI:IPI00 4 7 16.80% 475 52867 6.3 U Tax_Id=10090 Gene_Symbol=Psmc2 Putative uncharacterized protein * FOXO_KO.3 3.0208 0.3592 99.9 1869.919 1869.923 -1.8 105400.6* FOXO_KO.2 5.9835 0.4717 100 2123.024 2121.017 0.2 214708.5* FOXO_KO.2 4.8514 0.3939 100 3427.606 3426.611 -2.6 38560.6* FOXO_KO_w 3.7928 0.2813 99.9 1379.581 1379.582 -1.1 34516.2contamina 5 6 16.80% 469 50499 5 U no description

FOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9FOXO_KO.1 4.3926 0.3543 100 1301.656 1301.658 -2 249696.4

* FOXO_KO.3 7.0457 0.4579 100 2153.107 2151.1 0.2 206589.5FOXO_KO.1 5.4099 0.4586 100 2088.97 2087.966 0.1 86286.4

* FOXO_KO.1 7.3319 0.5344 100 2121.046 2120.047 -1.7 110556.8IPI:IPI00 1 1 16.80% 131 15604 7.1 U Tax_Id=10090 Gene_Symbol=Csnk2a1 Casein kinase 2, alpha 1 polypeptide IPI:IPI00 1 1 28.60% 77 9091 9.6 U Tax_Id=10090 Gene_Symbol=Csnk2a1 Csnk2a1 protein

FOXO_KO.2 4.7482 0.3552 99.9 2831.24 2830.238 -0.7 69788.7IPI:IPI00 1 1 16.80% 119 13282 11.6 U Tax_Id=10090 Gene_Symbol=Snrpd1 Small nuclear ribonucleoprotein Sm D1 IPI:IPI008 1 1 16.80% 119 13263 11.5 U Tax_Id=10090 Gene_Symbol=Gm14277 similar to small nuclear riboprotein Sm-D isoform 2

FOXO_KO.4 3.551 0.4027 100 2287.246 2287.247 -0.3 38473.7IPI:IPI001 6 6 16.60% 620 70367 8.8 U Tax_Id=10090 Gene_Symbol=Slc27a2 Very long-chain acyl-CoA synthetase

FOXO_KO.1 3.0114 0.2798 99.9 1142.585 1142.584 0.4 168602.8FOXO_KO.2 3.3681 0.252 99.5 2889.389 2888.391 -1.8 107912.1FOXO_KO.1 5.5336 0.5053 100 2171.005 2171.007 -1 53366.6FOXO_KO.5 4.5683 0.3937 99.9 3982.012 3981.003 1.3 21497.3FOXO_KO.5 4.9334 0.4591 100 3668.834 3666.829 -0.4 33345.3FOXO_KO.2 3.481 0.3986 100 1347.577 1347.577 -0.4 433511.6

contamina 16 22 16.60% 645 65865 8 U no descriptionFOXO_KO.1 4.5895 0.3602 100 1475.782 1475.785 -2.1 241573.9

* FOXO_KO.2 6.3586 0.585 100 2128.952 2127.95 -0.7 145032* FOXO_KO.2 6.3639 0.5124 100 2257.046 2256.045 -0.9 71877.6

FOXO_KO.4 7.2782 0.5489 100 2419.256 2418.251 0.5 125973.8FOXO_KO.4 5.169 0.4402 100 2420.264 2418.251 2.7 168871.3

* FOXO_KO.1 4.5063 0.2724 100 1331.643 1329.639 -1.9 492028.4* FOXO_KO.2 6.3044 0.463 100 1965.983 1964.978 0.5 263918.8* FOXO_KO.2 5.1463 0.44 100 1613.848 1613.849 -0.7 250066.3* FOXO_KO.2 4.0294 0.2609 99.9 1614.853 1613.849 0 274959.1* FOXO_KO.3 7.6901 0.4791 100 2199.142 2198.141 -1.1 153290.7* FOXO_KO.3 5.4119 0.428 100 2198.135 2198.141 -2.7 260884.6* FOXO_KO.3 3.6353 0.336 99.9 2199.146 2198.141 0.5 277296.9* FOXO_KO.2 5.051 0.3587 100 1371.712 1371.711 0.4 292456.8* FOXO_KO.3 3.6865 0.2309 99.7 1957.006 1956.003 -0.1 323474.1

FOXO_KO.1 2.9985 0.1926 99.7 1141.552 1139.54 4.4 309857.1* FOXO_KO.1 2.7022 0.2364 99.7 779.38 779.3795 0.6 63298.4IPI:IPI00 3 4 16.60% 145 16085 10.4 U Tax_Id=10090 Gene_Symbol=Rps19 40S ribosomal protein S19 IPI:IPI00 3 4 16.60% 145 16225 10.5 U Tax_Id=10090 Gene_Symbol=Gm4327;Gm8683 hypothetical protein IPI:IPI00 3 4 15.30% 157 17369 10.6 U Tax_Id=10090 Gene_Symbol=Rps19 Rps19 protein IPI:IPI00 3 4 33.30% 72 8103 9.7 U Tax_Id=10090 Gene_Symbol=Rps19 8 kDa protein IPI:IPI00 3 4 17.40% 138 15420 10.7 U Tax_Id=10090 Gene_Symbol=Rps19 15 kDa protein IPI:IPI00 3 4 11.30% 212 23104 10.5 U Tax_Id=10090 Gene_Symbol=Rps19 23 kDa protein

IPI:IPI00 3 4 13.60% 177 19445 10.4 U Tax_Id=10090 Gene_Symbol=Rps19 19 kDa protein IPI:IPI00 3 4 16.60% 145 16124 10.2 U Tax_Id=10090 Gene_Symbol=Gm6636 hypothetical protein

FOXO_KO.9 2.7484 0.3008 99.9 1134.553 1134.554 -1.2 196917.1FOXO_KO.2 4.709 0.3533 100 1969.925 1968.924 -1.2 317747.5FOXO_KO.2 4.2331 0.472 100 1704.773 1703.77 0 127715.5

IPI:IPI00 2 3 16.50% 194 22843 8.3 U Tax_Id=10090 Gene_Symbol=Fmr1 23 kDa protein FOXO_KO.2 5.7109 0.5295 100 2287.043 2286.042 -1.1 64236.5FOXO_KO.1 4.9082 0.4305 100 1556.696 1554.692 -1.7 187866.9

IPI:IPI007 27 38 16.40% 2472 284596 5.3 U Tax_Id=10090 Gene_Symbol=Spna2 Isoform 1 of Spectrin alpha chain, brain IPI:IPI00 27 38 16.40% 2477 285151 5.3 U Tax_Id=10090 Gene_Symbol=Spna2 Spectrin alpha 2

FOXO_KO.9 2.6284 0.3423 99.9 1302.653 1302.654 -0.8 1103516FOXO_KO.4 5.8996 0.5477 100 3900.819 3900.815 0.9 50796.3FOXO_KO.1 4.8635 0.4573 100 1849.875 1849.872 2 155281.5FOXO_KO.4 3.5955 0.3091 99.9 2155.11 2154.104 1.3 126376.4FOXO_KO.4 6.7971 0.4852 100 2420.229 2419.224 0.7 113289.2FOXO_KO.4 5.9958 0.5596 100 2696.273 2694.257 3.5 20065.6FOXO_KO.1 3.7008 0.3455 100 1292.583 1291.58 -0.2 380466.9FOXO_KO.3 6.6019 0.479 100 3003.341 3001.338 -1.4 229393.1FOXO_KO.1 3.683 0.2881 99.9 2495.219 2494.22 -1.6 190541.4FOXO_KO.3 2.5594 0.3049 99.7 2784.347 2783.344 -0.1 4348.7FOXO_KO.3 4.4738 0.1901 99.8 1777.923 1777.922 0.6 135453.2FOXO_KO_w 5.6156 0.3665 100 1724.89 1723.886 0.2 43555.4FOXO_KO.1 3.0951 0.2481 99.8 1259.669 1258.664 1.2 305359.4FOXO_KO.1 4.1474 0.3756 100 1480.594 1480.594 0 265184.9FOXO_KO.2 7.3342 0.4416 100 2295.142 2294.14 -0.6 93187.1FOXO_KO.2 3.1735 0.3669 99.9 2294.139 2294.14 -0.4 135597.8FOXO_KO.3 2.9371 0.3386 100 1433.679 1433.679 0 48817.4FOXO_KO.3 4.1819 0.3142 100 1435.683 1433.679 -2.3 200173.2FOXO_KO.5 7.2709 0.5639 100 2335.088 2334.081 1.3 46297.2FOXO_KO.5 3.5949 0.2427 99.5 3402.68 3401.679 -0.6 40294.8FOXO_KO.3 4.5204 0.3215 99.9 3269.555 3267.544 1.2 97992FOXO_KO.3 4.4866 0.3934 100 2928.366 2926.363 -1.3 11732.1FOXO_KO.3 4.6732 0.4295 100 2426.129 2426.126 1.1 39542.7FOXO_KO.3 6.2554 0.5786 100 2299.036 2298.031 0.7 69892.7FOXO_KO.2 4.7119 0.3973 100 1951.936 1951.936 0.4 90429.8FOXO_KO.3 8.2121 0.4873 100 1974.028 1973.026 -0.6 160792.1FOXO_KO.3 4.1812 0.1874 99.5 1974.027 1973.026 -1.2 188084.7

IPI:IPI001 21 30 16.40% 2154 251154 5.5 U Tax_Id=10090 Gene_Symbol=Spnb2 Isoform 2 of Spectrin beta chain, brain 1 FOXO_KO.1 3.4518 0.2963 99.9 1923.932 1922.934 -2.6 285415.2FOXO_KO.1 5.1352 0.3849 100 1722.824 1721.823 -1.5 177090.4FOXO_KO.1 5.5399 0.5114 100 1774.86 1774.861 -0.5 178873.7FOXO_KO.2 4.081 0.2504 99.7 2707.217 2705.215 -1.7 143286.9FOXO_KO.1 5.2871 0.467 100 1708.719 1707.717 -0.9 162507.6FOXO_KO.5 7.3967 0.5871 100 3158.578 3156.567 1.4 43217.8FOXO_KO.5 5.0203 0.4935 100 3002.474 3000.466 0.4 56155.6FOXO_KO.2 4.2218 0.3355 99.9 3746.831 3745.83 -0.8 75166.2FOXO_KO.3 5.1739 0.4043 100 2764.399 2762.393 -0.3 198223.9FOXO_KO.1 4.5093 0.4049 100 1651.736 1651.738 -1.5 185491.7

FOXO_KO.2 6.4708 0.4687 100 2320.128 2319.128 -1.6 44116.3FOXO_KO.2 4.6376 0.5058 100 2836.454 2835.448 0.7 175436.8FOXO_KO.1 7.6823 0.5254 100 2050.967 2049.964 -0.4 112626.2FOXO_KO.1 4.1012 0.2986 99.9 2636.248 2636.247 0.4 170965.2FOXO_KO.1 5.0222 0.4881 100 1887.928 1887.929 -0.8 119109.7FOXO_KO.3 7.6951 0.5176 100 2340.172 2338.167 -1 371875.3FOXO_KO.2 3.8909 0.3587 100 1503.717 1502.712 0.9 511128.8FOXO_KO.1 6.2757 0.5412 100 2528.188 2527.188 -1.4 250424.6FOXO_KO.5 4.5518 0.3573 100 1943.972 1943.971 0.6 82960.6FOXO_KO.5 4.3095 0.2139 99.8 1944.975 1943.971 0.2 74918.1FOXO_KO.2 3.2836 0.253 99.7 1993.95 1991.943 0.2 150651.9

IPI:IPI00 1 2 16.40% 116 13209 5.3 U Tax_Id=10090 Gene_Symbol=Cdkn2aipnl CDKN2AIP N-terminal-like protein IPI:IPI00 1 2 16.40% 116 13237 5.5 U Tax_Id=10090 Gene_Symbol=Cdkn2aipnl 13 kDa protein

FOXO_KO.3 5.5802 0.3629 100 2182.02 2181.02 -1.8 128838.6IPI:IPI00 4 5 16.30% 664 72585 7.4 U Tax_Id=10090 Gene_Symbol=Sdha Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial * FOXO_KO.4 5.0128 0.5331 100 3814.722 3813.716 0.7 45820.3* FOXO_KO.2 5.3245 0.4427 100 2953.346 2951.364 -8.1 79337.1* FOXO_KO.5 3.9652 0.2329 99.6 3554.762 3552.753 0.6 28284.7* FOXO_KO.9 5.2713 0.4749 100 1798.869 1797.865 0 229517.8IPI:IPI00 4 5 16.30% 429 46847 9.5 U Tax_Id=10090 Gene_Symbol=Dnaja3 Isoform 3 of DnaJ homolog subfamily A member 3, mitochondrial IPI:IPI00 4 5 14.60% 480 52443 9.2 U Tax_Id=10090 Gene_Symbol=Dnaja3 Isoform 1 of DnaJ homolog subfamily A member 3, mitochondrial

FOXO_KO.3 4.7752 0.437 100 1828.91 1827.901 3.2 69897.6FOXO_KO.3 3.5536 0.4018 100 1984.002 1984.002 0 118249.6FOXO_KO.5 4.7996 0.4376 100 2315.217 2313.209 0.7 81755.8FOXO_KO.3 3.7706 0.2386 99.5 3191.503 3191.509 -1.7 67679.7

IPI:IPI00 2 2 16.30% 172 19854 4.9 U Tax_Id=10090 Gene_Symbol=Myl9 Myosin regulatory light polypeptide 9 FOXO_KO.1 2.9561 0.3844 100 1237.56 1237.563 -2.5 232629.8FOXO_KO.3 3.2954 0.2835 99.7 2003.971 2003.974 -1.4 269817.1

IPI:IPI00 2 3 16.30% 104 12259 5.9 U Tax_Id=10090 Gene_Symbol=Erh;Gm10131 Enhancer of rudimentary homolog * FOXO_KO.1 5.5817 0.5695 100 2054.813 2054.814 -0.4 131458.7* FOXO_KO.1 3.363 0.3666 99.9 2056.82 2054.814 -0.5 141579.4IPI:IPI00 2 2 16.20% 290 31474 8.5 U Tax_Id=10090 Gene_Symbol=Echs1 Enoyl-CoA hydratase, mitochondrial

FOXO_KO.5 4.1627 0.3597 99.9 3785.917 3783.911 -0.2 11941.8FOXO_KO.1 3.2652 0.3382 100 1289.638 1289.641 -2 229340.9

IPI:IPI001 1 1 16.20% 235 26851 6.5 U Tax_Id=10090 Gene_Symbol=2700078K21Rik Isoform 1 of Mps one binder kinase activator-like 2 IPI:IPI005 1 1 25.30% 150 16990 6.6 U Tax_Id=10090 Gene_Symbol=2700078K21Rik Isoform 2 of Mps one binder kinase activator-like 2

FOXO_KO.2 5.2042 0.3335 99.9 3705.642 3704.64 -0.2 24513.5IPI:IPI004 1 1 16.20% 117 12972 8.6 U Tax_Id=10090 Gene_Symbol=- Ig heavy chain V region 7-39 * FOXO_KO.2 2.6497 0.339 99.7 2278.919 2278.93 -4.6 36272.1IPI:IPI00 3 3 16.10% 199 22176 8.1 U Tax_Id=10090 Gene_Symbol=Prdx1 Peroxiredoxin-1

FOXO_KO.1 3.3992 0.3591 100 1196.63 1196.631 -1.1 381595.5* FOXO_KO.1 5.3943 0.4189 100 2392.17 2392.171 -0.4 77543.8* FOXO_KO.1 4.8618 0.4726 100 2393.173 2392.171 -0.9 210203.8IPI:IPI003 4 4 16.00% 449 50784 5.4 U Tax_Id=10090 Gene_Symbol=G3bp2 Isoform B of Ras GTPase-activating protein-binding protein 2 * FOXO_KO.1 3.2497 0.4044 100 2148.056 2147.053 -0.2 49833.9


IPI:IPI007 26 36 15.90% 2452 282338 5.3 U Tax_Id=10090 Gene_Symbol=Spna2 Isoform 2 of Spectrin alpha chain, brain IPI:IPI00 26 36 15.80% 2478 285344 5.3 U Tax_Id=10090 Gene_Symbol=Spna2 spectrin alpha 2

FOXO_KO.9 2.6284 0.3423 99.9 1302.653 1302.654 -0.8 1103516FOXO_KO.4 5.8996 0.5477 100 3900.819 3900.815 0.9 50796.3FOXO_KO.1 4.8635 0.4573 100 1849.875 1849.872 2 155281.5FOXO_KO.4 3.5955 0.3091 99.9 2155.11 2154.104 1.3 126376.4FOXO_KO.4 6.7971 0.4852 100 2420.229 2419.224 0.7 113289.2FOXO_KO.4 5.9958 0.5596 100 2696.273 2694.257 3.5 20065.6FOXO_KO.1 3.7008 0.3455 100 1292.583 1291.58 -0.2 380466.9FOXO_KO.3 6.6019 0.479 100 3003.341 3001.338 -1.4 229393.1FOXO_KO.1 3.683 0.2881 99.9 2495.219 2494.22 -1.6 190541.4FOXO_KO.3 2.5594 0.3049 99.7 2784.347 2783.344 -0.1 4348.7FOXO_KO_w 5.6156 0.3665 100 1724.89 1723.886 0.2 43555.4FOXO_KO.1 3.0951 0.2481 99.8 1259.669 1258.664 1.2 305359.4FOXO_KO.1 4.1474 0.3756 100 1480.594 1480.594 0 265184.9FOXO_KO.2 7.3342 0.4416 100 2295.142 2294.14 -0.6 93187.1FOXO_KO.2 3.1735 0.3669 99.9 2294.139 2294.14 -0.4 135597.8FOXO_KO.3 2.9371 0.3386 100 1433.679 1433.679 0 48817.4FOXO_KO.3 4.1819 0.3142 100 1435.683 1433.679 -2.3 200173.2FOXO_KO.5 7.2709 0.5639 100 2335.088 2334.081 1.3 46297.2FOXO_KO.5 3.5949 0.2427 99.5 3402.68 3401.679 -0.6 40294.8FOXO_KO.3 4.5204 0.3215 99.9 3269.555 3267.544 1.2 97992FOXO_KO.3 4.4866 0.3934 100 2928.366 2926.363 -1.3 11732.1FOXO_KO.3 4.6732 0.4295 100 2426.129 2426.126 1.1 39542.7FOXO_KO.3 6.2554 0.5786 100 2299.036 2298.031 0.7 69892.7FOXO_KO.2 4.7119 0.3973 100 1951.936 1951.936 0.4 90429.8FOXO_KO.3 8.2121 0.4873 100 1974.028 1973.026 -0.6 160792.1FOXO_KO.3 4.1812 0.1874 99.5 1974.027 1973.026 -1.2 188084.7

IPI:IPI00 2 4 15.90% 151 17222 10.5 U Tax_Id=10090 Gene_Symbol=Rps13;Gm10159;LOC100044992;Gm6573;LOC100048340 40S ribosomal protein S13 IPI:IPI00 2 4 19.00% 126 14218 10.2 U Tax_Id=10090 Gene_Symbol=Gm12270 similar to Rps13 protein

FOXO_KO.1 2.9155 0.2214 99.8 968.4927 968.4908 2 169275.6FOXO_KO.3 4.4219 0.4512 100 1694.92 1693.916 0.3 263240

IPI:IPI00 8 12 15.80% 658 73428 7.5 U Tax_Id=10090 Gene_Symbol=Ddx3y ATP-dependent RNA helicase DDX3Y FOXO_KO_w 3.2496 0.3302 99.9 1232.553 1232.554 -1.3 66452.2FOXO_KO.1 4.0965 0.4435 100 1757.795 1757.798 -1.6 130057.5FOXO_KO.2 5.7021 0.5006 100 1882.918 1882.918 -0.2 85362.2FOXO_KO.1 3.3208 0.3056 99.9 1320.677 1320.679 -1.8 245487.9FOXO_KO.4 4.73 0.4418 100 1558.8 1557.795 1.2 162630.1FOXO_KO_w 3.4602 0.2204 99.9 1300.638 1300.639 -0.8 56139.4FOXO_KO.3 5.4304 0.5091 100 2084.028 2083.024 -0.1 146678.2FOXO_KO.3 3.3332 0.3399 100 1129.658 1128.651 2.9 337630.5

IPI:IPI002 3 10 15.80% 152 17691 10.4 U Tax_Id=10090 Gene_Symbol=Gm11230 similar to ribosomal protein FOXO_KO_w 3.9668 0.4067 100 1403.675 1403.676 -1 52628.2FOXO_KO_w 3.0781 0.3279 99.9 1403.672 1403.676 -2.9 77587.5FOXO_KO.1 3.6644 0.3632 100 1321.674 1321.675 -0.6 167963.7

IPI:IPI00 1 1 15.80% 76 8716 4.5 U Tax_Id=10090 Gene_Symbol=Hsp90ab1 9 kDa protein FOXO_KO.1 3.5135 0.3573 100 1275.642 1275.643 -0.5 477433.2

IPI:IPI00 6 19 15.70% 382 44318 9.6 U Tax_Id=10090 Gene_Symbol=Thrap3 Thrap3 protein (Fragment)

FOXO_KO_w 6.4794 0.4312 100 1987.893 1986.886 1.5 30426.2FOXO_KO_w 7.8936 0.4718 100 1986.887 1986.886 0.2 139568.6FOXO_KO.1 3.2287 0.2668 99.8 1446.682 1446.686 -2.5 238733.9FOXO_KO.1 3.325 0.349 99.9 1447.69 1446.686 0.1 278260FOXO_KO.1 5.2195 0.4599 100 1610.698 1610.7 -1.2 202007.6FOXO_KO.2 5.0151 0.3202 100 2150.011 2150.018 -3.3 232814.2

IPI:IPI00 3 3 15.70% 255 27821 9.3 U Tax_Id=10090 Gene_Symbol=Mccc1 28 kDa protein FOXO_KO.2 4.4141 0.2657 99.9 3071.36 3070.359 -0.9 72101FOXO_KO.1 4.4132 0.3511 100 1412.7 1410.693 0.2 281373.8FOXO_KO.1 3.3229 0.375 100 1282.596 1282.598 -1.8 418736.2

IPI:IPI00 1 3 15.70% 134 15241 5.1 U Tax_Id=10090 Gene_Symbol=Cyb5 Cytochrome b5 IPI:IPI00 1 3 21.40% 98 11142 5.3 U Tax_Id=10090 Gene_Symbol=Cyb5 11 kDa protein IPI:IPI00 1 3 19.10% 110 12286 5.5 U Tax_Id=10090 Gene_Symbol=Cyb5 12 kDa protein

FOXO_KO.1 6.0304 0.491 100 2206.928 2205.928 -1.7 98029.7IPI:IPI003 22 31 15.60% 2363 274221 5.6 U Tax_Id=10090 Gene_Symbol=Spnb2 Isoform 1 of Spectrin beta chain, brain 1 IPI:IPI00 22 31 17.60% 2092 244249 5.4 U Tax_Id=10090 Gene_Symbol=Spnb2 MKIAA4049 protein

FOXO_KO.2 5.0954 0.4897 100 1709.687 1708.683 0 212525.5FOXO_KO.1 3.4518 0.2963 99.9 1923.932 1922.934 -2.6 285415.2FOXO_KO.1 5.1352 0.3849 100 1722.824 1721.823 -1.5 177090.4FOXO_KO.1 5.5399 0.5114 100 1774.86 1774.861 -0.5 178873.7FOXO_KO.2 4.081 0.2504 99.7 2707.217 2705.215 -1.7 143286.9FOXO_KO.1 5.2871 0.467 100 1708.719 1707.717 -0.9 162507.6FOXO_KO.5 7.3967 0.5871 100 3158.578 3156.567 1.4 43217.8FOXO_KO.5 5.0203 0.4935 100 3002.474 3000.466 0.4 56155.6FOXO_KO.2 4.2218 0.3355 99.9 3746.831 3745.83 -0.8 75166.2FOXO_KO.3 5.1739 0.4043 100 2764.399 2762.393 -0.3 198223.9FOXO_KO.1 4.5093 0.4049 100 1651.736 1651.738 -1.5 185491.7FOXO_KO.2 6.4708 0.4687 100 2320.128 2319.128 -1.6 44116.3FOXO_KO.2 4.6376 0.5058 100 2836.454 2835.448 0.7 175436.8FOXO_KO.1 7.6823 0.5254 100 2050.967 2049.964 -0.4 112626.2FOXO_KO.1 4.1012 0.2986 99.9 2636.248 2636.247 0.4 170965.2FOXO_KO.1 5.0222 0.4881 100 1887.928 1887.929 -0.8 119109.7FOXO_KO.3 7.6951 0.5176 100 2340.172 2338.167 -1 371875.3FOXO_KO.2 3.8909 0.3587 100 1503.717 1502.712 0.9 511128.8FOXO_KO.1 6.2757 0.5412 100 2528.188 2527.188 -1.4 250424.6FOXO_KO.5 4.5518 0.3573 100 1943.972 1943.971 0.6 82960.6FOXO_KO.5 4.3095 0.2139 99.8 1944.975 1943.971 0.2 74918.1FOXO_KO.2 3.2836 0.253 99.7 1993.95 1991.943 0.2 150651.9

IPI:IPI00 1 1 15.60% 179 21984 7.8 U Tax_Id=10090 Gene_Symbol=Ndufb9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 * FOXO_KO.2 4.551 0.3904 99.9 3322.476 3322.471 1.4 86099.3IPI:IPI00 4 6 15.50% 373 42120 7.1 U Tax_Id=10090 Gene_Symbol=Glul Glutamine synthetase

FOXO_KO.3 3.7369 0.252 99.7 3968.711 3966.704 -0.1 29026.9FOXO_KO_w 2.7103 0.261 99.8 1002.499 1002.5 -1.2 125998FOXO_KO.2 5.513 0.4575 100 1815.831 1814.827 0.7 227015.5FOXO_KO.2 4.6372 0.4586 100 1928.868 1928.869 -0.8 192367

IPI:IPI00 1 1 15.50% 193 22006 6.6 U Tax_Id=10090 Gene_Symbol=Rhoc Rho-related GTP-binding protein RhoC IPI:IPI004 1 1 15.50% 193 21701 6.2 U Tax_Id=10090 Gene_Symbol=Gm12844;LOC631743 similar to Rho family GTPase RhoA IPI:IPI00 1 1 15.50% 193 21782 6.1 U Tax_Id=10090 Gene_Symbol=Rhoa Transforming protein RhoA

FOXO_KO.3 4.4518 0.4272 100 3466.701 3464.696 -0.6 48603.8IPI:IPI00 2 2 15.50% 84 9477 9.5 U Tax_Id=10090 Gene_Symbol=Rps27l 40S ribosomal protein S27-like IPI:IPI00 2 2 16.90% 77 8619 8.8 U Tax_Id=10090 Gene_Symbol=Rps27l 9 kDa protein IPI:IPI00 2 2 12.40% 105 11829 8.5 U Tax_Id=10090 Gene_Symbol=Rps27l 12 kDa protein

FOXO_KO.1 3.02 0.269 99.8 1309.662 1309.663 -0.9 1416640FOXO_KO.9 3.211 0.2483 99.8 1565.849 1565.853 -3 293946.9

IPI:IPI00 2 5 15.50% 84 9461 9.5 U Tax_Id=10090 Gene_Symbol=Gm9846;Rps27 40S ribosomal protein S27 IPI:IPI008 2 5 14.60% 89 10004 9.5 U Tax_Id=10090 Gene_Symbol=Gm4180 similar to ribosomal protein S27

FOXO_KO.1 2.908 0.2216 99.6 1293.631 1293.632 -0.7 280971.7FOXO_KO_w 4.2846 0.4533 100 1577.828 1577.828 -0.2 88068.6

IPI:IPI00 5 6 15.40% 661 74718 8.1 U Tax_Id=10090 Gene_Symbol=Acox1 Putative uncharacterized protein FOXO_KO.3 4.2086 0.3947 100 2736.303 2735.295 1.7 12736.5FOXO_KO.3 3.5181 0.3958 100 1711.799 1711.804 -2.7 120949FOXO_KO.3 3.8145 0.287 99.9 3236.617 3236.616 0.4 221722.1FOXO_KO.3 4.6914 0.4279 100 2506.323 2505.32 -0.1 157103.7FOXO_KO.3 4.5158 0.487 100 1747.8 1747.796 2 145366.3

IPI:IPI00 3 3 15.40% 397 41858 8.1 U Tax_Id=10090 Gene_Symbol=Acaa2 3-ketoacyl-CoA thiolase, mitochondrial IPI:IPI00 3 3 15.40% 397 41830 8.1 U Tax_Id=10090 Gene_Symbol=Acaa2 Acetyl-Coenzyme A acyltransferase 2 (Mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_k


IPI:IPI00 4 6 15.40% 306 33300 8.1 U Tax_Id=10090 Gene_Symbol=Mccc2 Mccc2 protein FOXO_KO.1 6.1774 0.549 100 2057.919 2057.919 -0.4 118537FOXO_KO.1 3.7935 0.3793 99.9 2057.918 2057.919 -0.7 286133.2FOXO_KO.9 5.9939 0.3276 100 1705.76 1704.761 -2.8 155360FOXO_KO.2 4.1833 0.387 100 1515.752 1514.749 0.3 238446.1

IPI:IPI00 2 34 15.40% 298 32886 9 U Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase subunit gamma, mitochondrial IPI:IPI00 2 34 16.80% 274 30256 8.8 U Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit isoform b

FOXO_KO.5 6.2445 0.369 100 3648.839 3646.832 0.3 29439FOXO_KO.3 3.7294 0.3252 100 1315.719 1314.715 0.3 70783.1

IPI:IPI00 3 10 15.40% 143 17031 10.6 U Tax_Id=10090 Gene_Symbol=Rpl26 Ribosomal protein L26 IPI:IPI00 3 10 15.20% 145 17217 10.6 U Tax_Id=10090 Gene_Symbol=- 17 kDa protein

FOXO_KO.1 2.6118 0.239 99.6 1082.525 1082.527 -1.1 327202.9FOXO_KO_w 4.9906 0.2555 100 1613.79 1612.789 -1.4 66281.1FOXO_KO_w 3.541 0.2257 99.7 1613.793 1612.789 0.5 95148.8

IPI:IPI002 4 4 15.40% 143 16733 11 U Tax_Id=10090 Gene_Symbol=LOC100047828;Gm10027 similar to ribosomal protein isoform 1 FOXO_KO.2 3.8452 0.2817 99.9 2534.3 2533.301 -1.4 177906.9FOXO_KO.1 3.6644 0.3632 100 1321.674 1321.675 -0.6 167963.7FOXO_KO.2 4.2011 0.3516 100 2235.142 2233.157 -9.6 156217.9FOXO_KO.2 3.6373 0.3544 99.9 2234.162 2233.157 0.9 313309.9

IPI:IPI00 8 10 15.30% 937 104583 5.4 U Tax_Id=10090 Gene_Symbol=Ap2b1 Isoform 1 of AP-2 complex subunit beta IPI:IPI00 8 10 15.00% 951 105722 5.3 U Tax_Id=10090 Gene_Symbol=Ap2b1 Isoform 2 of AP-2 complex subunit beta

FOXO_KO.3 3.957 0.3183 100 2426.159 2424.142 4.3 69838.8FOXO_KO.1 2.8485 0.3122 99.9 1229.564 1228.563 -1.6 320461.6FOXO_KO.5 4.75 0.4615 100 2993.571 2992.563 1.7 66765.2FOXO_KO.3 4.5518 0.5291 100 2927.378 2926.377 -0.8 77774.2FOXO_KO.5 6.4732 0.5138 100 3589.837 3588.832 0.5 73510.8FOXO_KO.5 3.7103 0.3273 99.9 3590.836 3588.832 -0.6 129045.8

FOXO_KO.3 4.3941 0.4542 100 2911.466 2911.464 0.7 66390.3FOXO_KO.3 5.3996 0.4248 100 3184.61 3182.592 3.4 91495.1

IPI:IPI00 2 2 15.30% 261 28785 4.8 U Tax_Id=10090 Gene_Symbol=Pcna Proliferating cell nuclear antigen IPI:IPI00 2 2 16.10% 248 27300 4.7 U Tax_Id=10090 Gene_Symbol=LOC100046823 similar to proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) isoform 2 IPI:IPI00 2 2 15.30% 261 28785 4.8 U Tax_Id=10090 Gene_Symbol=LOC100046823 similar to proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) isoform 1 IPI:IPI00 2 2 15.30% 262 29024 4.8 U Tax_Id=10090 Gene_Symbol=Pcna Proliferating cell nuclear antigen

FOXO_KO.2 5.1117 0.3745 100 2074.99 2074.993 -1.2 84292.6FOXO_KO.3 4.8615 0.3427 100 2480.216 2479.21 1.4 49556.2

IPI:IPI00 3 6 15.30% 248 27855 8.5 U Tax_Id=10090 Gene_Symbol=Psma7 Proteasome subunit alpha type-7 * FOXO_KO.1 5.3536 0.5455 100 1726.798 1726.802 -2.2 213711.2* FOXO_KO.3 3.8475 0.3368 99.9 2804.425 2803.425 -1.2 52230.6* FOXO_KO.7 5.9611 0.4371 100 1738.855 1737.854 -1.7 45278.9IPI:IPI00 2 2 15.30% 124 14700 4.1 U Tax_Id=10090 Gene_Symbol=Paip2 Polyadenylate-binding protein-interacting protein 2 * FOXO_KO.3 6.8725 0.4716 100 2510.08 2509.08 -1.3 76818* FOXO_KO.3 3.1944 0.2654 99.6 2510.085 2509.08 0.9 509146.3IPI:IPI00 4 5 15.20% 453 49486 9.3 U Tax_Id=10090 Gene_Symbol=Dnaja3 Isoform 2 of DnaJ homolog subfamily A member 3, mitochondrial

FOXO_KO.3 4.7752 0.437 100 1828.91 1827.901 3.2 69897.6FOXO_KO.3 3.5536 0.4018 100 1984.002 1984.002 0 118249.6FOXO_KO.5 4.7996 0.4376 100 2315.217 2313.209 0.7 81755.8

* FOXO_KO.3 3.7347 0.3347 99.9 3107.477 3106.481 -2.3 150807.1IPI:IPI00 3 9 15.20% 315 36108 5.1 U Tax_Id=10090 Gene_Symbol=Eif2s1 Eukaryotic translation initiation factor 2 subunit 1 * FOXO_KO.2 4.4733 0.4738 100 2434.225 2434.225 0 175969.4* FOXO_KO.3 4.6962 0.3507 99.9 3191.599 3190.597 -0.6 88239.2* FOXO_KO.3 4.2138 0.2406 99.7 3191.599 3190.597 -0.5 252855IPI:IPI00 3 5 15.20% 263 29547 6.4 U Tax_Id=10090 Gene_Symbol=Psma1 Proteasome subunit alpha type-1 * FOXO_KO.1 3.8871 0.4154 100 1778.805 1778.809 -2.4 141851.7* FOXO_KO.4 4.3942 0.3788 100 2604.173 2603.167 0.9 15132.1* FOXO_KO.3 4.0764 0.2701 99.9 2986.388 2984.38 0.5 30268.3IPI:IPI00 5 5 15.20% 244 28556 8.2 U Tax_Id=10090 Gene_Symbol=Gstm1 Glutathione S-transferase, mu 1

FOXO_KO.1 3.3644 0.2152 99.8 1594.717 1593.699 9.5 416145.4FOXO_KO.1 5.2026 0.4242 100 1750.803 1749.8 -0.1 261194.2FOXO_KO.1 2.6738 0.3064 99.8 1444.632 1443.632 -2.2 462928FOXO_KO.1 2.6907 0.4523 100 1287.529 1287.531 -1.8 342630.5FOXO_KO.1 3.5502 0.4729 100 1390.663 1390.663 -0.1 237705.5

IPI:IPI00 4 7 15.20% 151 16273 10.1 U Tax_Id=10090 Gene_Symbol=Rps14 40S ribosomal protein S14 IPI:IPI00 4 7 16.70% 138 14735 8.9 U Tax_Id=10090 Gene_Symbol=Rps14 15 kDa protein IPI:IPI00 4 7 19.30% 119 12711 9 U Tax_Id=10090 Gene_Symbol=Rps14 13 kDa protein

FOXO_KO.1 4.1854 0.3531 99.9 2493.213 2492.22 -3.9 254339.4FOXO_KO.2 6.7403 0.5492 100 2266.061 2265.056 0.7 103179.9FOXO_KO.2 3.3387 0.3075 99.9 2265.055 2265.056 -0.5 332642.3FOXO_KO.2 6.3354 0.5682 100 1923.892 1922.891 -1.5 121336.8

IPI:IPI00 3 3 15.20% 138 15882 5.2 U Tax_Id=10090 Gene_Symbol=Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d FOXO_KO.1 4.5086 0.1686 99.8 2446.243 2445.24 0 39593.9FOXO_KO.1 4.2027 0.3882 99.9 2445.238 2445.24 -0.5 219119.9FOXO_KO.9 4.2715 0.374 100 1667.818 1666.817 -1.4 470893.4

IPI:IPI00 5 6 15.10% 470 52029 5.2 U Tax_Id=10090 Gene_Symbol=Fam82a2 Regulator of microtubule dynamics protein 3 FOXO_KO.1 4.3271 0.5581 100 1854.803 1854.802 0.9 108065.1FOXO_KO.1 3.572 0.3546 99.9 1855.804 1854.802 -0.8 211135.8

* FOXO_KO.2 4.8137 0.459 100 2182.104 2181.103 -1.2 124533.9* FOXO_KO.1 4.9777 0.4464 100 1789.779 1789.78 -0.1 127794.7* FOXO_KO.1 4.1254 0.3641 100 1904.924 1904.924 -0.1 102521.8IPI:IPI00 9 12 15.00% 419 47154 11 U Tax_Id=10090 Gene_Symbol=Rpl4 60S ribosomal protein L4 * FOXO_KO.1 3.8222 0.4726 100 1580.817 1580.817 0 221568.6* FOXO_KO.2 5.6264 0.4057 100 2536.349 2535.345 0 191655.8* FOXO_KO.2 3.6776 0.2612 99.7 2536.35 2535.345 0.7 141179.9* FOXO_KO.2 2.7706 0.2855 99.5 2664.438 2663.44 -2.2 192405.1* FOXO_KO.2 5.8173 0.5496 100 2186.164 2185.164 -1.6 95060.8* FOXO_KO.2 3.5954 0.4211 99.9 2313.259 2313.259 0 1228503* FOXO_KO.1 4.3811 0.3112 100 1761.896 1761.895 0.6 93979.8* FOXO_KO.1 3.8251 0.319 100 1605.79 1605.794 -2.4 201385.6* FOXO_KO.1 3.2982 0.2936 99.9 1280.66 1280.663 -2.3 312133.3IPI:IPI00 2 2 15.00% 321 36540 6.8 U Tax_Id=10090 Gene_Symbol=Psmd7 26S proteasome non-ATPase regulatory subunit 7 * FOXO_KO.2 6.4048 0.584 100 2574.226 2573.225 -0.9 51494.9* FOXO_KO.2 6.4621 0.5199 100 2682.308 2681.305 -0.2 155412.5IPI:IPI00 3 3 15.00% 153 16734 6.8 U Tax_Id=10090 Gene_Symbol=Actg1 Actin, gamma, cytoplasmic 1

FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.8 3.4566 0.4039 100 1516.694 1516.703 -5.9 462543.8FOXO_KO.8 2.8206 0.2602 99.5 1516.696 1516.703 -4.3 692797

IPI:IPI002 4 7 14.90% 415 45730 5.5 U Tax_Id=10090 Gene_Symbol=Hnrnpf Isoform 1 of Heterogeneous nuclear ribonucleoprotein F IPI:IPI007 4 7 15.70% 395 43685 5.5 U Tax_Id=10090 Gene_Symbol=Hnrnpf Isoform 2 of Heterogeneous nuclear ribonucleoprotein F

FOXO_KO.1 4.822 0.3747 100 1782.817 1781.808 3.7 178306.3FOXO_KO_w 3.9561 0.5633 100 1630.719 1630.721 -1 32032FOXO_KO.3 4.8848 0.4321 100 1867.946 1867.944 1.1 85982.8FOXO_KO.1 4.0445 0.4489 100 1616.683 1616.683 -0.1 171266

IPI:IPI00 5 8 14.90% 355 38354 7.8 U Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 1 of Heterogeneous nuclear ribonucleoprotein D0 IPI:IPI003 5 8 17.30% 306 32754 8.2 U Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 3 of Heterogeneous nuclear ribonucleoprotein D0

FOXO_KO.1 3.468 0.39 99.9 1972.865 1971.864 -1.1 45351.7FOXO_KO.1 4.0413 0.3188 100 1488.756 1488.758 -1.6 271153.4FOXO_KO.3 5.2964 0.343 100 2431.168 2430.165 0 68423.9FOXO_KO.3 4.1674 0.2917 99.9 2431.168 2430.165 -0.1 391428.4FOXO_KO.3 5.7203 0.4828 100 2162.978 2160.98 -3.8 123987

IPI:IPI00 2 2 14.90% 148 16601 11.2 U Tax_Id=10090 Gene_Symbol=Gm4923 similar to ribosomal protein L27a-like IPI:IPI00 2 2 14.90% 148 16605 11.1 U Tax_Id=10090 Gene_Symbol=Rpl27a;Gm7536 ribosomal protein L27a IPI:IPI00 2 2 14.90% 148 16682 11 U Tax_Id=10090 Gene_Symbol=Gm5908 hypothetical protein IPI:IPI001 2 2 15.10% 146 16468 11.3 U Tax_Id=10090 Gene_Symbol=Gm8213 similar to ribosomal protein L27a-like IPI:IPI00 2 2 15.00% 147 16394 11.1 U Tax_Id=10090 Gene_Symbol=Gm6378 similar to ribosomal protein L27a-like

FOXO_KO.1 3.7433 0.4196 100 1422.667 1422.668 -0.7 1229798FOXO_KO.4 5.2461 0.1025 99.8 2637.315 2636.314 -0.6 36948.6

IPI:IPI00 3 4 14.90% 114 11475 4.3 U Tax_Id=10090 Gene_Symbol=Rplp1 60S acidic ribosomal protein P1 IPI:IPI00 3 4 19.10% 89 8854 4.1 U Tax_Id=10090 Gene_Symbol=- similar to acidic ribosomal phosphoprotein P1 isoform 2 IPI:IPI008 3 4 19.10% 89 8750 4.2 U Tax_Id=10090 Gene_Symbol=Gm10073 similar to acidic ribosomal phosphoprotein P1 isoform 2 IPI:IPI00 3 4 14.90% 114 11537 4.3 U Tax_Id=10090 Gene_Symbol=- similar to acidic ribosomal phosphoprotein P1 isoform 1 IPI:IPI001 3 4 14.90% 114 11433 4.4 U Tax_Id=10090 Gene_Symbol=Gm10073 similar to acidic ribosomal phosphoprotein P1 isoform 1 IPI:IPI001 3 4 14.90% 114 11551 4.3 U Tax_Id=10090 Gene_Symbol=Gm11942 similar to acidic ribosomal phosphoprotein P1 isoform 1

FOXO_KO.2 5.3698 0.5316 100 1964.777 1963.775 -0.5 128859.1FOXO_KO.3 3.1394 0.4335 100 2043.741 2043.741 -0.1 120030.6

FOXO_KO.3 3.8143 0.4612 100 2123.71 2123.708 1.3 91504IPI:IPI00 1 1 14.90% 87 10219 9.1 U Tax_Id=10090 Gene_Symbol=Dars aspartyl-tRNA synthetase isoform 2

FOXO_KO.1 4.0982 0.334 100 1508.72 1508.723 -1.9 209335.4IPI:IPI00 4 4 14.80% 488 55302 5.9 U Tax_Id=10090 Gene_Symbol=Hdac2 Histone deacetylase 2

FOXO_KO.6 6.7864 0.5791 100 2355.238 2354.231 1.6 45425FOXO_KO.2 5.5785 0.4094 100 2027.024 2025.018 -0.3 112853.7FOXO_KO.2 3.3274 0.3341 99.9 2026.019 2025.018 -0.9 155676.9

* FOXO_KO.1 4.1057 0.251 99.7 3667.554 3665.552 -1.4 30009IPI:IPI00 5 9 14.80% 465 51829 5.6 U Tax_Id=10090 Gene_Symbol=G3bp1 Ras GTPase-activating protein-binding protein 1

FOXO_KO.1 4.1566 0.3817 100 1804.812 1804.811 0.1 156648.9FOXO_KO.1 4.2532 0.4347 100 1804.81 1804.811 -0.8 137504.4

* FOXO_KO.4 4.6412 0.3793 99.9 4108.053 4106.052 -1.4 74442.7* FOXO_KO.3 4.5876 0.3772 100 1585.784 1584.781 0.2 189621.7* FOXO_KO.3 4.9669 0.5565 100 1937.964 1937.964 -0.2 118419.9IPI:IPI001 6 8 14.80% 284 32837 4.7 U Tax_Id=10090 Gene_Symbol=Tpm2 Isoform 1 of Tropomyosin beta chain IPI:IPI008 6 8 14.80% 284 32958 4.7 U Tax_Id=10090 Gene_Symbol=Tpm2 Isoform 2 of Tropomyosin beta chain IPI:IPI00 6 8 13.60% 308 34797 5.3 U Tax_Id=10090 Gene_Symbol=Tpm2 Tpm2 protein

FOXO_KO.1 2.8718 0.294 99.8 1599.736 1599.738 -1.6 159082.8FOXO_KO.1 3.6839 0.3411 100 1399.753 1399.754 -0.4 147174.3FOXO_KO.1 2.9435 0.253 99.5 1883.991 1883.993 -1.3 194207.4FOXO_KO.1 3.0829 0.2862 99.9 1243.652 1243.653 -0.7 333755.6FOXO_KO.1 4.5436 0.2757 100 1728.894 1727.892 -0.7 352965FOXO_KO.1 3.866 0.3314 100 1477.679 1476.681 -3.6 200530.9

IPI:IPI00 3 9 14.70% 416 47995 4.5 U Tax_Id=10090 Gene_Symbol=Calr Calreticulin * FOXO_KO.2 5.092 0.4441 100 2520.198 2519.194 0.3 120824.1* FOXO_KO.9 4.5509 0.4503 100 1784.842 1784.845 -1.8 173199.5* FOXO_KO.1 4.3379 0.3903 99.9 2761.266 2760.263 -0.4 94336.5IPI:IPI002 4 5 14.60% 745 85001 4.9 U Tax_Id=10090 Gene_Symbol=Hnrnpul2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 IPI:IPI00 4 5 14.60% 745 84868 4.9 U Tax_Id=10090 Gene_Symbol=- similar to heterogeneous nuclear ribonucleoprotein U-like 2

FOXO_KO.2 4.1799 0.2344 99.7 2546.149 2545.155 -3.5 178333.4FOXO_KO.3 3.4195 0.349 99.9 4197.913 4196.907 0.6 7664.8FOXO_KO.2 4.4127 0.4824 100 1821.83 1820.829 -1.6 237616.9FOXO_KO.2 4.1354 0.4167 99.9 3635.705 3633.698 0.2 38020.7

IPI:IPI00 3 5 14.60% 288 31275 9.9 U Tax_Id=10090 Gene_Symbol=Gm5978 hypothetical protein isoform 1 IPI:IPI006 3 5 16.40% 256 28278 9.1 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein S2 isoform 2 IPI:IPI00 3 5 14.30% 293 31124 10.1 U Tax_Id=10090 Gene_Symbol=Gm5921 hypothetical protein isoform 1


IPI:IPI00 1 1 14.60% 171 19702 9.1 U Tax_Id=10090 Gene_Symbol=Ddx18 Protein FOXO_KO.3 4.5456 0.4496 100 3009.464 3009.463 0.4 107463.9

IPI:IPI00 1 1 14.60% 151 17444 5.2 U Tax_Id=10090 Gene_Symbol=Ndufb11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial * FOXO_KO.1 4.3958 0.3207 99.9 2720.19 2719.194 -2.9 118147.3IPI:IPI00 5 6 14.50% 463 50932 5.8 U Tax_Id=10090 Gene_Symbol=- 51 kDa protein

FOXO_KO.9 5.3147 0.4099 100 1579.703 1579.706 -1.8 225521.2FOXO_KO.8 4.7697 0.4788 100 1735.801 1735.807 -3.4 139915FOXO_KO.8 4.1325 0.2851 99.9 1735.801 1735.807 -3.4 1996603FOXO_KO.1 4.9431 0.4986 100 1781.802 1780.798 0 325850.2

FOXO_KO.3 2.7025 0.3196 99.5 4137.006 4134.998 0.4 10758.7IPI:IPI00 3 10 14.50% 297 31682 10.2 U Tax_Id=10090 Gene_Symbol=Rps2 Putative uncharacterized protein IPI:IPI00 3 10 14.20% 302 32105 9.9 U Tax_Id=10090 Gene_Symbol=Rps2 32 kDa protein IPI:IPI007 3 10 14.70% 293 31364 9.9 U Tax_Id=10090 Gene_Symbol=Gm8842 hypothetical protein isoform 2 IPI:IPI004 3 10 14.70% 293 31309 10.1 U Tax_Id=10090 Gene_Symbol=LOC639606 hypothetical protein isoform 1

FOXO_KO.1 3.8773 0.2957 100 1315.688 1315.689 -0.6 234571.9FOXO_KO.5 6.1524 0.4522 100 3687.998 3685.987 1.2 28799.6FOXO_KO.4 6.6858 0.5034 100 2154.142 2153.138 0.5 257113.6

IPI:IPI00 7 7 14.40% 806 89322 5.3 U Tax_Id=10090 Gene_Symbol=Vcp Transitional endoplasmic reticulum ATPase IPI:IPI006 7 7 14.50% 801 88851 5.3 U Tax_Id=10090 Gene_Symbol=LOC675857 similar to valosin isoform 1

FOXO_KO.1 4.2285 0.3991 100 1840.793 1840.794 -0.5 78378.6FOXO_KO.3 5.5668 0.4118 100 3673.789 3672.792 -1.7 81886.7FOXO_KO.3 3.2909 0.2525 99.8 2342.184 2342.176 3.1 44321.3FOXO_KO.3 4.6248 0.5445 100 2499.278 2498.277 -1.1 57245.5FOXO_KO.1 5.3004 0.4036 100 1824.917 1823.917 -2.2 159896.7FOXO_KO.2 2.4105 0.3159 99.8 1049.554 1049.551 2.3 127253.7FOXO_KO.2 3.4746 0.3452 99.9 2155.982 2155.981 0.2 45068.9

IPI:IPI00 2 2 14.40% 194 21316 4.4 U Tax_Id=10090 Gene_Symbol=Psmd4 21 kDa protein FOXO_KO.1 4.5333 0.4337 100 2658.281 2658.285 -1.7 29731.1FOXO_KO.1 4.3202 0.3388 99.9 2659.287 2658.285 -0.6 132103.7

IPI:IPI00 2 4 14.30% 315 37118 4.6 U Tax_Id=10090 Gene_Symbol=Calu calumenin isoform 2 FOXO_KO.1 3.7733 0.4242 99.9 2507.086 2506.091 -3.1 152285.7FOXO_KO.1 4.948 0.3156 99.9 2751.249 2749.241 0.5 83129.5

IPI:IPI006 8 16 14.30% 357 37063 8 U Tax_Id=10090 Gene_Symbol=LOC630401 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 5 IPI:IPI007 8 16 16.50% 310 32880 8.3 U Tax_Id=10090 Gene_Symbol=LOC630401 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 6 IPI:IPI006 8 16 16.80% 304 32432 7.8 U Tax_Id=10090 Gene_Symbol=LOC630401 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1

FOXO_KO.2 5.0963 0.312 99.9 2570.292 2569.293 -1.8 77274FOXO_KO.3 6.337 0.49 100 2441.196 2441.198 -1 116799.3FOXO_KO.1 4.1873 0.4477 100 1582.777 1582.778 -0.8 226391.8FOXO_KO.1 3.393 0.3538 100 1234.596 1234.598 -1.9 299622.8FOXO_KO.2 3.7799 0.3821 100 1869.875 1869.877 -0.7 125442.9FOXO_KO.2 4.3631 0.3994 100 1869.874 1869.877 -1.3 298207.1FOXO_KO.2 5.5601 0.4986 100 1713.773 1713.776 -1.8 660872.2FOXO_KO.2 2.8561 0.3168 99.8 1713.774 1713.776 -0.9 248223.5

IPI:IPI00 1 1 14.30% 217 23334 5.1 U Tax_Id=10090 Gene_Symbol=Pgrmc2 Membrane-associated progesterone receptor component 2 * FOXO_KO.3 5.7066 0.4467 100 3560.671 3559.668 0 47051.5IPI:IPI00 3 4 14.30% 203 22690 9.5 U Tax_Id=10090 Gene_Symbol=Wibg Isoform 1 of Partner of Y14 and mago IPI:IPI00 3 4 14.40% 202 22679 9.5 U Tax_Id=10090 Gene_Symbol=Wibg Isoform 2 of Partner of Y14 and mago

FOXO_KO.1 4.3549 0.393 100 1781.844 1779.844 -3.6 94444.5FOXO_KO.3 3.1073 0.3653 99.9 1656.872 1656.869 1.9 160908.7FOXO_KO.3 3.2581 0.4542 100 1500.77 1500.768 1.4 71507.1

IPI:IPI00 1 1 14.30% 98 11273 5.1 U Tax_Id=10090 Gene_Symbol=Spnb2 11 kDa protein FOXO_KO.2 5.0954 0.4897 100 1709.687 1708.683 0 212525.5

IPI:IPI00 3 3 14.20% 465 53517 6.4 U Tax_Id=10090 Gene_Symbol=Mina Myc-induced nuclear antigen FOXO_KO.4 6.4115 0.4526 100 3254.701 3252.693 0.6 86528.6

* FOXO_KO.1 4.1589 0.474 100 2252.136 2251.135 -1.2 164455.7* FOXO_KO.2 3.4583 0.3575 99.9 2035.929 2034.926 0 103076IPI:IPI00 3 3 14.20% 367 40512 8.9 U Tax_Id=10090 Gene_Symbol=Drg1 Developmentally-regulated GTP-binding protein 1

* FOXO_KO.1 5.9728 0.4858 100 2348.148 2347.145 0 88781.9* FOXO_KO.2 5.1201 0.4928 100 1689.794 1689.793 0.8 185828* FOXO_KO.2 5.516 0.4381 100 1653.833 1653.833 0.1 237231.4IPI:IPI00 2 2 14.20% 211 24762 5.5 U Tax_Id=10090 Gene_Symbol=Cald1 Protein IPI:IPI00 2 2 10.90% 274 32305 9 U Tax_Id=10090 Gene_Symbol=Cald1 Protein

FOXO_KO.3 4.6917 0.381 100 1643.786 1643.787 -0.7 26534.5FOXO_KO.1 3.5826 0.2088 99.8 1528.823 1528.822 1 206314.9

IPI:IPI00 2 2 14.10% 262 29363 9.1 U Tax_Id=10090 Gene_Symbol=Slc27a2 Solute carrier family 27 (Fatty acid transporter), member 2 FOXO_KO.1 3.0114 0.2798 99.9 1142.585 1142.584 0.4 168602.8FOXO_KO.2 3.3681 0.252 99.5 2889.389 2888.391 -1.8 107912.1

IPI:IPI00 1 1 14.10% 71 7755 5.7 U Tax_Id=10090 Gene_Symbol=Actc1 Actin alpha cardiac FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7

IPI:IPI00 2 2 14.00% 215 24942 5.6 U Tax_Id=10090 Gene_Symbol=Csnk2b Casein kinase II subunit beta * FOXO_KO.3 3.0792 0.3596 99.9 3677.672 3676.665 1.1 38293.6* FOXO_KO.3 3.4109 0.266 99.6 3676.665 3676.665 -0.1 106790.3IPI:IPI00 3 7 14.00% 207 24008 11.5 U Tax_Id=10090 Gene_Symbol=LOC675192;Gm9026 hypothetical protein IPI:IPI00 3 7 13.70% 211 24305 11.5 U Tax_Id=10090 Gene_Symbol=Gm15710;Rpl13;Gm12918 60S ribosomal protein L13

FOXO_KO.2 2.6936 0.2223 99.7 950.4943 950.4941 0.2 242881.9FOXO_KO_w 4.0975 0.3839 100 1232.62 1232.623 -2.3 98539.8FOXO_KO_w 3.4205 0.3688 100 1236.644 1236.647 -2.2 61767.1

IPI:IPI001 2 2 14.00% 157 18325 6.6 U Tax_Id=10090 Gene_Symbol=Mup1;Mup2;Mup7;Mup10 Putative uncharacterized protein IPI:IPI00 2 2 12.20% 180 20637 5.2 U Tax_Id=10090 Gene_Symbol=Mup13;Mup14 Novel member of the major urinary protein (Mup) gene family IPI:IPI00 2 2 12.20% 180 20638 5 U Tax_Id=10090 Gene_Symbol=CU041261.1 Novel member of the major urinary protein (Mup) gene family IPI:IPI00 2 2 23.40% 94 10796 4.9 U Tax_Id=10090 Gene_Symbol=Mup13;Mup14 11 kDa protein IPI:IPI00 2 2 14.70% 150 17365 4.8 U Tax_Id=10090 Gene_Symbol=Mup13;Mup14 Novel member of the major urinary protein (Mup) gene family IPI:IPI00 2 2 12.20% 180 20600 5.1 U Tax_Id=10090 Gene_Symbol=Mup2;Mup7;Mup1 Novel member of the major urinary protein (Mup) gene family IPI:IPI00 2 2 9.40% 235 26837 5.2 U Tax_Id=10090 Gene_Symbol=Mup13 major urinary protein 13 IPI:IPI00 2 2 9.40% 235 26860 5.2 U Tax_Id=10090 Gene_Symbol=Mup17 similar to major urinary protein 1 IPI:IPI00 2 2 9.40% 235 26848 5.1 U Tax_Id=10090 Gene_Symbol=Mup8 major urinary protein 8 IPI:IPI00 2 2 9.40% 235 26799 5.2 U Tax_Id=10090 Gene_Symbol=Mup2;Mup7;LOC100048883 major urinary protein 7

FOXO_KO.3 4.5157 0.424 100 2471.174 2471.176 -0.6 30200.9FOXO_KO.3 4.4789 0.4434 100 2472.181 2471.176 0.8 164469.9

IPI:IPI00 1 1 14.00% 121 12620 4.4 U Tax_Id=10090 Gene_Symbol=Golga3 13 kDa protein FOXO_KO.1 7.3649 0.5761 100 1886.891 1885.889 -0.4 135641.3

IPI:IPI00 1 2 14.00% 100 10753 8.9 U Tax_Id=10090 Gene_Symbol=Hsph1 11 kDa protein FOXO_KO.2 3.5232 0.5204 100 1479.707 1479.707 -0.6 232169.2

IPI:IPI00 1 1 13.90% 201 22705 5.2 U Tax_Id=10090 Gene_Symbol=Tmed2;Gm10698 Transmembrane emp24 domain-containing protein 2 IPI:IPI00 1 1 26.90% 104 12180 5.8 U Tax_Id=10090 Gene_Symbol=Tmed2 Putative uncharacterized protein

FOXO_KO.4 3.7677 0.2515 99.7 3131.494 3130.485 1.7 71848.5IPI:IPI00 1 1 13.90% 115 12882 9.5 U Tax_Id=10090 Gene_Symbol=Gm6109 similar to ribosomal protein L30 IPI:IPI00 1 1 13.90% 115 12827 9.2 U Tax_Id=10090 Gene_Symbol=Gm6570 similar to ribosomal protein L30 IPI:IPI008 1 1 13.90% 115 12930 9.6 U Tax_Id=10090 Gene_Symbol=Gm2648 similar to ribosomal protein L30 IPI:IPI004 1 1 13.90% 115 12832 9.6 U Tax_Id=10090 Gene_Symbol=Gm7429 similar to ribosomal protein L30 IPI:IPI00 1 1 13.90% 115 12822 9.2 U Tax_Id=10090 Gene_Symbol=Gm6570 similar to ribosomal protein L30 IPI:IPI00 1 1 13.90% 115 12784 9.6 U Tax_Id=10090 Gene_Symbol=Rpl30;Gm8808 60S ribosomal protein L30

FOXO_KO.2 3.3233 0.3073 99.9 1757.915 1757.91 2.7 184131.6IPI:IPI004 3 5 13.80% 325 36587 7.4 U Tax_Id=10090 Gene_Symbol=Akr1a4 Alcohol dehydrogenase [NADP+] IPI:IPI00 3 5 15.20% 296 33238 7.2 U Tax_Id=10090 Gene_Symbol=LOC100044692 similar to aldehyde reductase

FOXO_KO.2 7.5464 0.598 100 2751.296 2750.294 -0.3 259737.3FOXO_KO.3 5.914 0.4622 100 2099.147 2098.143 0 128509.9FOXO_KO.3 3.7376 0.3649 99.9 2098.143 2098.143 -0.1 126586.9

IPI:IPI00 1 1 13.80% 240 27427 7.6 U Tax_Id=10090 Gene_Symbol=Gstt1 Putative uncharacterized protein IPI:IPI00 1 1 13.80% 240 27374 7.3 U Tax_Id=10090 Gene_Symbol=Gstt1 glutathione S-transferase, theta 1 IPI:IPI00 1 1 14.20% 232 26041 6.9 U Tax_Id=10090 Gene_Symbol=Gstt1 26 kDa protein IPI:IPI005 1 1 13.80% 240 27376 7.3 U Tax_Id=10090 Gene_Symbol=Gstt1 Glutathione S-transferase theta-1

FOXO_KO.5 5.1017 0.3725 100 3641.929 3639.923 -0.2 37178.8IPI:IPI00 1 1 13.80% 218 24570 6.7 U Tax_Id=10090 Gene_Symbol=Hprt Hypoxanthine-guanine phosphoribosyltransferase * FOXO_KO.3 5.2572 0.4154 100 3439.582 3437.573 0.7 70511.7IPI:IPI00 2 5 13.80% 196 23466 11.5 U Tax_Id=10090 Gene_Symbol=Rpl19 60S ribosomal protein L19 IPI:IPI00 2 5 13.90% 194 23248 11.5 U Tax_Id=10090 Gene_Symbol=Rpl19 ribosomal protein L19 isoform 2 IPI:IPI00 2 5 13.80% 196 23438 11.4 U Tax_Id=10090 Gene_Symbol=Gm15360 similar to Mus musculus ribosomal protein L19

FOXO_KO.1 5.5471 0.5393 100 2071.02 2071.02 -0.2 100901.1FOXO_KO_w 2.9389 0.3009 99.9 986.5261 986.5266 -0.5 63583.8

IPI:IPI00 2 3 13.80% 145 16284 8.6 U Tax_Id=10090 Gene_Symbol=LOC100044630;Tomm20;Gm14494 Mitochondrial import receptor subunit TOM20 homolog IPI:IPI00 2 3 15.90% 126 13956 4.7 U Tax_Id=10090 Gene_Symbol=Gm15365 similar to Translocase of outer mitochondrial membrane 20 homolog

FOXO_KO.4 6.1004 0.4937 100 2371.176 2371.17 2.5 92240.8FOXO_KO.4 3.8409 0.3186 99.9 2372.175 2371.17 0.3 112550.2

IPI:IPI00 8 14 13.70% 717 79344 7.8 U Tax_Id=10090 Gene_Symbol=Mccc1 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial FOXO_KO.2 4.4141 0.2657 99.9 3071.36 3070.359 -0.9 72101FOXO_KO.1 4.4132 0.3511 100 1412.7 1410.693 0.2 281373.8FOXO_KO.1 3.3229 0.375 100 1282.596 1282.598 -1.8 418736.2FOXO_KO.2 3.449 0.4573 100 2035.058 2035.061 -1.4 154083

* FOXO_KO.9 3.3265 0.3747 100 1285.535 1285.537 -1.1 52694.3* FOXO_KO.9 3.7653 0.4556 100 1285.534 1285.537 -1.9 311088.9* FOXO_KO.1 5.0399 0.3803 100 1657.781 1656.778 -0.5 236052.1* FOXO_KO.1 4.6982 0.5207 100 1658.755 1658.754 0.4 170652.3IPI:IPI001 1 1 13.70% 204 22889 9.7 U Tax_Id=10090 Gene_Symbol=Rps5 40S ribosomal protein S5

FOXO_KO.5 4.5847 0.3321 99.9 3066.695 3065.69 0.6 64851.5IPI:IPI002 1 1 13.70% 161 17853 8.9 U Tax_Id=10090 Gene_Symbol=1200014J11Rik Isoform 3 of Uncharacterized protein C17orf85 homolog IPI:IPI00 1 1 3.60% 615 70043 5.8 U Tax_Id=10090 Gene_Symbol=1200014J11Rik Isoform 1 of Uncharacterized protein C17orf85 homolog IPI:IPI008 1 1 18.20% 121 13426 7.3 U Tax_Id=10090 Gene_Symbol=1200014J11Rik Isoform 2 of Uncharacterized protein C17orf85 homolog

FOXO_KO.2 3.4928 0.2956 99.9 2228.062 2227.064 -2.4 57837.9IPI:IPI001 4 6 13.60% 214 24486 9.8 U Tax_Id=10090 Gene_Symbol=Gm4892 similar to QM protein IPI:IPI00 4 6 17.40% 167 18789 9.7 U Tax_Id=10090 Gene_Symbol=Rpl10 Ribosomal protein 10 IPI:IPI00 4 6 21.50% 135 15148 9.8 U Tax_Id=10090 Gene_Symbol=Rpl10 QM protein (Fragment) IPI:IPI004 4 6 13.60% 214 24547 10.1 U Tax_Id=10090 Gene_Symbol=Gm5621 similar to QM protein isoform 2 IPI:IPI00 4 6 13.60% 214 24558 10.1 U Tax_Id=10090 Gene_Symbol=Rpl10l 60S ribosomal protein L10-like

FOXO_KO.3 6.4864 0.4383 100 3281.533 3281.509 7.5 151646.7FOXO_KO.3 5.6295 0.3993 100 3083.379 3082.377 -0.5 52707.7FOXO_KO.3 5.0166 0.431 100 3084.378 3082.377 -1.8 134063.1FOXO_KO.3 3.3446 0.3291 99.9 3083.376 3082.377 -1.3 136302.4

IPI:IPI00 2 5 13.60% 221 23936 8 U Tax_Id=10090 Gene_Symbol=Eno1 Enolase FOXO_KO.1 3.7412 0.4086 100 1280.584 1280.586 -2 228053.6FOXO_KO.2 5.8971 0.4147 100 1962.927 1960.925 -2.3 185038.2

IPI:IPI00 7 9 13.50% 837 94945 6.5 U Tax_Id=10090 Gene_Symbol=Abcf1 ATP-binding cassette sub-family F member 1 IPI:IPI00 7 9 13.50% 836 94816 6.6 U Tax_Id=10090 Gene_Symbol=Abcf1 ATP-binding cassette, sub-family F (GCN20), member 1

FOXO_KO.1 4.799 0.4473 100 2138.973 2137.967 1.1 35431.4FOXO_KO.2 4.0616 0.2642 99.9 2099.988 2098.981 1.7 93671.6FOXO_KO.2 4.6839 0.4315 100 2050.014 2049.013 -1.4 61832.9FOXO_KO.3 5.6539 0.3813 100 2668.119 2667.118 -0.8 39085.7FOXO_KO.1 5.9653 0.4832 100 2130.087 2129.083 0.4 275642.7FOXO_KO.1 5.3221 0.4478 100 1972.98 1972.982 -1.1 126773.3FOXO_KO.1 4.0499 0.2969 100 1655.773 1655.776 -1.8 251774.6

IPI:IPI00 6 6 13.50% 541 62280 8 U Tax_Id=10090 Gene_Symbol=Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 precursor IPI:IPI00 6 6 13.80% 530 60874 7.9 U Tax_Id=10090 Gene_Symbol=Ugt2b5 MCG1789

FOXO_KO.6 3.9874 0.4014 100 3161.447 3159.436 1.5 14389.4FOXO_KO.6 4.7173 0.4957 100 3160.443 3159.436 1.2 60140.9FOXO_KO.6 3.8318 0.3727 99.9 3279.744 3278.738 0.9 48777.8FOXO_KO.4 4.2115 0.4106 100 1979.998 1979.996 0.9 69083FOXO_KO.4 4.3605 0.3927 100 1981.002 1979.996 1.3 111805.7FOXO_KO.4 5.6693 0.3764 100 2109.1 2108.091 2.7 137740.2

IPI:IPI00 4 7 13.50% 466 53688 5.1 U Tax_Id=10090 Gene_Symbol=Vim Vimentin * FOXO_KO.1 4.1685 0.2561 99.9 1688.827 1688.827 0.1 186202.8* FOXO_KO.2 7.2532 0.5547 100 2201.984 2200.981 -0.2 268263* FOXO_KO.1 4.4551 0.4151 100 1734.811 1734.815 -2.1 139804.9* FOXO_KO.9 4.4552 0.3528 100 1836.798 1836.799 -0.8 97297.2IPI:IPI00 2 6 13.50% 319 35167 8.6 U Tax_Id=10090 Gene_Symbol=Aimp1 small inducible cytokine subfamily E, member 1 * FOXO_KO.3 6.1684 0.4027 100 2591.373 2589.388 -8.3 170891.5* FOXO_KO.1 4.8079 0.403 100 2299.111 2297.105 -0.1 180925.5IPI:IPI00 2 2 13.50% 111 13561 9.1 U Tax_Id=10090 Gene_Symbol=Uqcrb MCG67985 IPI:IPI00 2 2 13.50% 111 13527 9.1 U Tax_Id=10090 Gene_Symbol=Uqcrb Cytochrome b-c1 complex subunit 7

FOXO_KO.1 4.6942 0.1185 99.8 1770.85 1770.85 -0.1 129870.5FOXO_KO.1 2.4795 0.3205 99.6 1770.845 1770.85 -3.1 407868.2

IPI:IPI00 6 24 13.40% 403 46125 10.1 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 1 IPI:IPI00 6 24 15.30% 354 40174 10.2 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 3

FOXO_KO.2 5.4225 0.5099 100 1763.922 1761.917 -0.8 418329.8FOXO_KO.2 3.5993 0.3585 99.9 1761.915 1761.917 -1.4 549226.4FOXO_KO.3 4.7221 0.4499 100 2972.523 2971.519 0.1 34723.6FOXO_KO.3 3.6762 0.4546 100 2973.503 2971.519 -7.8 96087FOXO_KO_w 2.8484 0.3534 100 1342.574 1342.576 -1 10932.4FOXO_KO_w 4.0559 0.4968 100 1342.575 1342.576 -0.9 293345.8

IPI:IPI00 3 6 13.40% 186 20708 8.6 U Tax_Id=10090 Gene_Symbol=Eef1a1 21 kDa protein FOXO_KO.1 4.7207 0.4242 100 1611.81 1610.809 -1.8 257581.1FOXO_KO.1 2.9504 0.3486 99.9 1610.807 1610.809 -1.3 232010.8FOXO_KO_w 3.2454 0.3006 99.9 1282.561 1282.562 -0.8 34817.7

IPI:IPI00 4 4 13.20% 340 37979 8.6 U Tax_Id=10090 Gene_Symbol=Mosc1 MOSC domain-containing protein 1, mitochondrial IPI:IPI00 4 4 13.10% 344 38502 8.7 U Tax_Id=10090 Gene_Symbol=LOC100045982 similar to MOSC domain-containing protein 1, mitochondrial isoform 1

FOXO_KO.3 6.5132 0.4459 100 1714.768 1712.758 1.5 305329.4FOXO_KO.3 6.2447 0.495 100 2956.46 2955.458 -0.5 41577.6FOXO_KO.3 3.1855 0.2966 99.7 2956.461 2955.458 -0.1 92024.6FOXO_KO.4 4.7513 0.3198 99.9 3355.697 3353.686 1.2 213995.1

IPI:IPI00 10 13 13.10% 996 112533 8.1 U Tax_Id=10090 Gene_Symbol=Zc3hav1 Isoform 1 of Zinc finger CCCH-type antiviral protein 1 FOXO_KO.5 4.081 0.2846 99.9 2534.36 2532.352 0.7 26596.9FOXO_KO.5 3.8985 0.2742 99.9 2533.351 2532.352 -1.6 60093.9

FOXO_KO.4 4.5086 0.429 100 3359.659 3357.649 0.8 92973.5FOXO_KO.2 4.2959 0.4774 100 1882.845 1882.845 -0.5 130026.6FOXO_KO.5 4.5521 0.4143 100 2662.254 2661.252 -0.4 28221.3

* FOXO_KO.2 4.3533 0.3174 100 2795.235 2794.233 -0.3 19880.6* FOXO_KO.2 3.6105 0.2777 99.7 2795.232 2794.233 -1.5 88419.2* FOXO_KO.3 5.2063 0.5199 100 2076.995 2075.988 1.6 116142.1* FOXO_KO.3 4.4195 0.263 99.9 2076.995 2075.988 1.6 119585.9* FOXO_KO.3 5.5628 0.3891 100 2334.127 2333.126 -0.9 116755.7IPI:IPI00 3 4 13.10% 291 31665 5.2 U Tax_Id=10090 Gene_Symbol=Exosc7 Exosome complex exonuclease RRP42 IPI:IPI00 3 4 13.10% 291 31825 5.2 U Tax_Id=10090 Gene_Symbol=Exosc7 MCG23310, isoform CRA_b

FOXO_KO.2 5.9827 0.3824 100 2583.16 2581.161 -2.8 39319FOXO_KO.2 4.9712 0.3584 99.9 2582.158 2581.161 -2.3 162956.1FOXO_KO.3 4.3904 0.3941 100 1786.79 1786.787 1.4 106137.1

IPI:IPI00 1 1 13.10% 282 31320 7.1 U Tax_Id=10090 Gene_Symbol=Esd S-formylglutathione hydrolase * FOXO_KO.3 2.9012 0.2908 99.5 4087.968 4085.965 -1 12477.4IPI:IPI00 2 3 13.10% 206 24301 9.5 U Tax_Id=10090 Gene_Symbol=Mrpl40 39S ribosomal protein L40, mitochondrial IPI:IPI00 2 3 16.70% 162 19378 9.2 U Tax_Id=10090 Gene_Symbol=Mrpl40 19 kDa protein

FOXO_KO.4 5.4231 0.4897 100 2937.481 2936.481 -1.1 101264.1FOXO_KO.3 6.3395 0.4005 100 3093.586 3092.582 0.2 92512.8

IPI:IPI00 1 1 13.10% 137 15677 5.6 U Tax_Id=10090 Gene_Symbol=Acsl1 16 kDa protein FOXO_KO.3 6.5545 0.4584 100 2178.082 2176.081 -2.4 239360.2

IPI:IPI008 7 8 13.00% 1106 128819 5.6 U Tax_Id=10090 Gene_Symbol=Usp7 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 7 FOXO_KO.4 5.8057 0.575 100 2389.006 2389.008 -0.9 71802.4FOXO_KO.3 4.4207 0.3394 99.9 3730.725 3729.719 0.7 45733.8FOXO_KO.9 4.7883 0.4109 100 2447.077 2445.074 -1.4 297794.3FOXO_KO.3 4.5398 0.2883 99.9 3233.519 3232.52 -1.3 72141.9FOXO_KO.2 4.1052 0.388 100 1719.916 1719.916 -0.4 80336.9FOXO_KO.1 5.1758 0.3879 100 1793.836 1793.834 1 135098.4FOXO_KO.2 4.8486 0.368 99.9 3288.489 3286.486 -1.1 139271.3

IPI:IPI00 10 16 13.00% 912 104977 5.4 U Tax_Id=10090 Gene_Symbol=Actn4 Alpha-actinin-4 FOXO_KO.2 3.1976 0.2807 99.7 1921.929 1920.93 -2.2 135718FOXO_KO.1 3.2523 0.2534 99.9 1300.674 1299.669 1.1 28397.5FOXO_KO.2 5.3648 0.485 100 1903.943 1903.94 1.7 153546.3FOXO_KO.2 4.0242 0.273 99.9 1903.939 1903.94 -0.2 231426.3FOXO_KO.1 5.8741 0.438 100 1817.875 1816.875 -1.5 212571.5FOXO_KO.1 6.9508 0.535 100 2089.968 2088.966 -0.6 133572.6FOXO_KO.1 3.1331 0.248 99.5 2089.968 2088.966 -0.6 153705.8FOXO_KO.1 2.8954 0.2981 99.9 1255.605 1255.605 -0.4 325987.6FOXO_KO_w 6.4706 0.575 100 1754.827 1753.825 -0.7 24820.2

* FOXO_KO.2 5.7381 0.5774 100 1742.811 1741.813 -2.8 157527.6IPI:IPI00 5 8 13.00% 699 75442 9.4 U Tax_Id=10090 Gene_Symbol=Sfpq Splicing factor, proline- and glutamine-rich IPI:IPI00 5 8 14.10% 646 70102 9.3 U Tax_Id=10090 Gene_Symbol=LOC100045887 similar to PTB-associated splicing factor

FOXO_KO.3 4.4709 0.5301 100 1807.912 1807.911 0.4 224727.7FOXO_KO.4 5.343 0.4953 100 2639.303 2639.299 1.7 42809.7FOXO_KO.4 3.4179 0.3919 99.9 2639.299 2639.299 0 71394.9FOXO_KO.3 4.4932 0.2953 99.9 3597.811 3596.804 1 93312.2FOXO_KO.2 7.7558 0.5887 100 2430.121 2428.12 -2.3 138882.5

IPI:IPI00 7 11 13.00% 615 67853 9.5 U Tax_Id=10090 Gene_Symbol=Pabpc4 Poly(A) binding protein, cytoplasmic 4

IPI:IPI00 7 11 13.00% 615 67759 9.5 U Tax_Id=10090 Gene_Symbol=- 68 kDa protein IPI:IPI00 7 11 12.40% 644 70665 9.3 U Tax_Id=10090 Gene_Symbol=Pabpc4 Poly A binding protein, cytoplasmic 4 IPI:IPI00 7 11 12.70% 631 69430 9.6 U Tax_Id=10090 Gene_Symbol=Pabpc4 Poly A binding protein, cytoplasmic 4 IPI:IPI00 7 11 12.10% 660 72242 9.4 U Tax_Id=10090 Gene_Symbol=Pabpc4 MCG5546, isoform CRA_c

FOXO_KO.2 5.4185 0.3913 100 1928.912 1928.914 -0.9 183360.2FOXO_KO.1 5.4766 0.3856 100 1713.793 1712.792 -1 101707.2FOXO_KO.1 4.8403 0.4726 100 2155.051 2154.05 -1.3 176626.6FOXO_KO.3 7.0531 0.6044 100 2274.073 2273.072 -0.9 89316FOXO_KO.3 3.3875 0.3812 99.9 2273.074 2273.072 1 136513.5FOXO_KO.4 6.0407 0.5297 100 2741.394 2740.389 0.6 25547.1FOXO_KO.4 3.6745 0.4621 100 2741.396 2740.389 1.3 45001.9

IPI:IPI00 3 3 13.00% 422 47362 4.7 U Tax_Id=10090 Gene_Symbol=Nap1l4 Putative uncharacterized protein IPI:IPI00 3 3 14.70% 375 42679 4.7 U Tax_Id=10090 Gene_Symbol=Nap1l4 Nucleosome assembly protein 1-like 4

FOXO_KO.1 2.9587 0.2441 99.8 1336.616 1336.617 -0.6 349745.7FOXO_KO.4 5.0566 0.4461 100 2136.059 2135.058 -0.9 65336FOXO_KO.3 6.6279 0.5392 100 3115.339 3114.334 0.4 71734.6

IPI:IPI00 1 2 13.00% 138 16285 9.8 U Tax_Id=10090 Gene_Symbol=Ccdc47 Coiled-coil domain containing 47 IPI:IPI00 1 2 10.80% 167 19846 9.8 U Tax_Id=10090 Gene_Symbol=Ccdc47 Isoform 3 of Coiled-coil domain-containing protein 47

FOXO_KO.5 3.0803 0.2363 99.6 2112.052 2112.043 4.6 28310.4IPI:IPI002 1 1 13.00% 115 13047 10.9 U Tax_Id=10090 Gene_Symbol=Gm6654 similar to ribosomal protein S26 IPI:IPI007 1 1 17.00% 88 10029 10.4 U Tax_Id=10090 Gene_Symbol=Gm7392 similar to ribosomal protein S26, isoform 1 IPI:IPI006 1 1 13.00% 115 13051 10.9 U Tax_Id=10090 Gene_Symbol=Gm6654 similar to ribosomal protein S26 IPI:IPI00 1 1 13.00% 115 13015 11 U Tax_Id=10090 Gene_Symbol=Rps26;LOC100047845 40S ribosomal protein S26

FOXO_KO.3 4.4099 0.4283 100 1653.84 1653.837 1.5 367688.2IPI:IPI00 4 4 12.90% 551 60706 8.9 U Tax_Id=10090 Gene_Symbol=Lactb;LOC677144 Serine beta-lactamase-like protein LACTB, mitochondrial

FOXO_KO.2 5.3243 0.4873 100 1724.796 1723.792 0.4 242794.7FOXO_KO.2 4.7506 0.3994 100 2775.358 2774.356 -0.4 130246.7

* FOXO_KO.2 3.97 0.3803 99.9 2678.309 2676.297 1.8 107409.1* FOXO_KO.1 2.8708 0.42 100 1292.647 1292.648 -0.8 327567.3IPI:IPI00 1 2 12.90% 210 23474 6.4 U Tax_Id=10090 Gene_Symbol=Bag2 BAG family molecular chaperone regulator 2 * FOXO_KO.4 7.197 0.4763 100 3101.523 3099.509 2.4 126471.8IPI:IPI00 1 11 12.90% 140 14865 10.5 U Tax_Id=10090 Gene_Symbol=Rpl23 60S ribosomal protein L23 IPI:IPI00 1 11 13.40% 134 14459 10.5 U Tax_Id=10090 Gene_Symbol=LOC100044627 similar to HL23 ribosomal protein

FOXO_KO.6 5.6435 0.4251 100 2016.003 2013.992 2.3 32524.4IPI:IPI00 4 5 12.80% 444 50305 5.6 U Tax_Id=10090 Gene_Symbol=Chd4 50 kDa protein

FOXO_KO.1 2.8215 0.2922 99.5 3505.522 3504.52 -0.3 33497.6FOXO_KO.1 4.9158 0.4083 100 3506.523 3504.52 -0.9 143749.2FOXO_KO.3 4.1673 0.3431 99.9 2976.359 2975.357 -0.6 88078.8FOXO_KO.3 6.824 0.52 100 2480.067 2478.061 -0.3 37783

IPI:IPI00 3 3 12.80% 368 39590 5.1 U Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10C of 26S proteasome non-ATPase regulatory subunit 4 IPI:IPI003 3 3 12.40% 379 41046 4.8 U Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10B of 26S proteasome non-ATPase regulatory subunit 4

FOXO_KO.2 3.7369 0.3438 99.9 2207.091 2206.087 0 171113.4FOXO_KO.1 4.5333 0.4337 100 2658.281 2658.285 -1.7 29731.1FOXO_KO.1 4.3202 0.3388 99.9 2659.287 2658.285 -0.6 132103.7

IPI:IPI00 3 3 12.80% 304 34690 7.9 U Tax_Id=10090 Gene_Symbol=Hdac2 Putative uncharacterized protein FOXO_KO.6 6.7864 0.5791 100 2355.238 2354.231 1.6 45425FOXO_KO.2 5.5785 0.4094 100 2027.024 2025.018 -0.3 112853.7FOXO_KO.2 3.3274 0.3341 99.9 2026.019 2025.018 -0.9 155676.9

IPI:IPI001 1 1 12.80% 164 19330 11.6 U Tax_Id=10090 Gene_Symbol=Sfrs3 Isoform Long of Splicing factor, arginine/serine-rich 3 IPI:IPI00 1 1 12.90% 163 19130 11.4 U Tax_Id=10090 Gene_Symbol=Gm12355 MCG21910 IPI:IPI004 1 1 13.50% 156 18374 11.5 U Tax_Id=10090 Gene_Symbol=LOC100047744;Gm9761 similar to MGC89287 protein IPI:IPI002 1 1 16.90% 124 14203 10.1 U Tax_Id=10090 Gene_Symbol=Sfrs3 Isoform Short of Splicing factor, arginine/serine-rich 3

FOXO_KO.2 4.2858 0.4352 100 2320.098 2320.099 -0.7 98010.8IPI:IPI00 1 1 12.80% 125 13708 10.1 U Tax_Id=10090 Gene_Symbol=Gm4963 similar to ribosomal protein S25 IPI:IPI008 1 1 16.50% 97 10806 10.1 U Tax_Id=10090 Gene_Symbol=Gm2225 similar to ribosomal protein S25 isoform 1 IPI:IPI00 1 1 14.70% 109 12239 9.5 U Tax_Id=10090 Gene_Symbol=LOC100045659 similar to hCG1640785 IPI:IPI006 1 1 12.80% 125 13738 10.1 U Tax_Id=10090 Gene_Symbol=- similar to hCG1640785 IPI:IPI006 1 1 20.50% 78 8868 10 U Tax_Id=10090 Gene_Symbol=Gm6029 similar to MGC82151 protein IPI:IPI004 1 1 12.80% 125 13737 10.2 U Tax_Id=10090 Gene_Symbol=Gm6988 similar to hCG1640785 IPI:IPI00 1 1 12.80% 125 13742 10.1 U Tax_Id=10090 Gene_Symbol=Rps25 40S ribosomal protein S25

FOXO_KO.2 4.8169 0.4229 100 1897.003 1897.007 -1.6 249947.8IPI:IPI003 7 8 12.70% 573 60956 6.2 U Tax_Id=10090 Gene_Symbol=Hspd1 Isoform 1 of 60 kDa heat shock protein, mitochondrial

FOXO_KO.1 5.5768 0.461 100 2562.248 2560.249 -2.9 32572.7FOXO_KO.1 4.5723 0.4054 100 2562.251 2560.249 -1.6 125304.6FOXO_KO.3 4.4619 0.4147 100 1505.757 1504.756 -2 391997.8FOXO_KO.3 5.6505 0.4459 100 1923.955 1922.953 -0.5 194460.2FOXO_KO.3 3.0483 0.2823 99.7 1922.95 1922.953 -1.3 163719.2FOXO_KO.2 3.4659 0.4296 100 1601.751 1601.752 -0.2 350550.5FOXO_KO.2 6.1171 0.3609 100 2298.146 2297.139 1.2 133837.8

IPI:IPI007 2 2 12.70% 490 52383 4.7 U Tax_Id=10090 Gene_Symbol=Lrrfip1 Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 FOXO_KO.2 5.2256 0.3466 99.9 3261.515 3260.511 0.2 61589.3FOXO_KO.1 5.782 0.4492 100 3074.431 3073.43 -0.9 147489.4

IPI:IPI00 1 1 12.70% 221 24914 4.6 U Tax_Id=10090 Gene_Symbol=Ndfip1 NEDD4 family-interacting protein 1 IPI:IPI00 1 1 9.40% 299 33631 5.4 U Tax_Id=10090 Gene_Symbol=LOC100046168 similar to Nedd4 WW domain-binding protein 5

FOXO_KO.2 4.6096 0.4248 100 3192.503 3192.508 -1.7 158967.8IPI:IPI00 1 1 12.70% 204 22631 7.1 U Tax_Id=10090 Gene_Symbol=Akr1a4 Aldo-keto reductase family 1, member A4

FOXO_KO.2 7.5464 0.598 100 2751.296 2750.294 -0.3 259737.3IPI:IPI00 1 1 12.70% 204 21135 4.1 U Tax_Id=10090 Gene_Symbol=Hnrnpul2 Putative uncharacterized protein

FOXO_KO.2 4.1799 0.2344 99.7 2546.149 2545.155 -3.5 178333.4IPI:IPI00 1 1 12.70% 181 20046 4.8 U Tax_Id=10090 Gene_Symbol=1110004F10Rik Small acidic protein IPI:IPI00 1 1 28.40% 81 9195 10.2 U Tax_Id=10090 Gene_Symbol=1110004F10Rik 9 kDa protein

FOXO_KO.2 5.9704 0.5015 100 2436.027 2435.023 0.3 56824IPI:IPI00 1 1 12.70% 102 11687 8.5 U Tax_Id=10090 Gene_Symbol=Mgst1 12 kDa protein

FOXO_KO.1 3.573 0.4441 100 1411.632 1411.631 0.3 207628.7IPI:IPI00 1 1 12.70% 110 11667 5 U Tax_Id=10090 Gene_Symbol=D10Ertd641e UPF0448 protein C10orf104 homolog * FOXO_KO.3 3.8617 0.4831 100 1629.807 1629.812 -3.2 124743.4IPI:IPI004 7 8 12.60% 1143 132749 5.6 U Tax_Id=10090 Gene_Symbol=Usp7 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 7 IPI:IPI008 7 8 13.10% 1100 127996 5.4 U Tax_Id=10090 Gene_Symbol=Usp7 Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 7

FOXO_KO.4 5.8057 0.575 100 2389.006 2389.008 -0.9 71802.4FOXO_KO.3 4.4207 0.3394 99.9 3730.725 3729.719 0.7 45733.8FOXO_KO.9 4.7883 0.4109 100 2447.077 2445.074 -1.4 297794.3FOXO_KO.3 4.5398 0.2883 99.9 3233.519 3232.52 -1.3 72141.9FOXO_KO.2 4.1052 0.388 100 1719.916 1719.916 -0.4 80336.9FOXO_KO.1 5.1758 0.3879 100 1793.836 1793.834 1 135098.4FOXO_KO.2 4.8486 0.368 99.9 3288.489 3286.486 -1.1 139271.3

IPI:IPI00 5 5 12.60% 724 83281 5 U Tax_Id=10090 Gene_Symbol=Hsp90ab1 MCG18238

IPI:IPI005 5 5 12.60% 724 83325 5 U Tax_Id=10090 Gene_Symbol=Hsp90ab1 Heat shock protein HSP 90-beta FOXO_KO.1 3.5135 0.3573 100 1275.642 1275.643 -0.5 477433.2FOXO_KO.1 5.2858 0.4612 100 1847.795 1847.797 -0.9 177936.5FOXO_KO.2 4.1229 0.2474 99.9 2116.025 2116.027 -0.9 139797.9FOXO_KO.3 5.1693 0.5055 100 2449.149 2448.146 -0.1 55558.3FOXO_KO.5 4.0837 0.3396 99.9 2989.541 2988.531 2 23973.2

IPI:IPI001 1 2 12.60% 239 27640 7.3 U Tax_Id=10090 Gene_Symbol=Derl2 Isoform 1 of Derlin-2 * FOXO_KO.2 3.7787 0.2694 99.7 3406.542 3404.545 -3 45416.7IPI:IPI001 3 5 12.60% 214 24223 8.6 U Tax_Id=10090 Gene_Symbol=Gm6564 similar to QM protein

FOXO_KO.3 5.6295 0.3993 100 3083.379 3082.377 -0.5 52707.7FOXO_KO.3 5.0166 0.431 100 3084.378 3082.377 -1.8 134063.1FOXO_KO.3 3.3446 0.3291 99.9 3083.376 3082.377 -1.3 136302.4

IPI:IPI00 3 3 12.60% 183 22222 10.3 U Tax_Id=10090 Gene_Symbol=Sfrs13a Isoform 3 of Splicing factor, arginine/serine-rich 13A IPI:IPI00 3 3 12.60% 182 22135 10.3 U Tax_Id=10090 Gene_Symbol=Sfrs13a Putative uncharacterized protein IPI:IPI00 3 3 8.80% 261 31213 11.3 U Tax_Id=10090 Gene_Symbol=Sfrs13a Isoform 2 of Splicing factor, arginine/serine-rich 13A IPI:IPI00 3 3 8.30% 278 33158 11.1 U Tax_Id=10090 Gene_Symbol=Sfrs13a Putative uncharacterized protein

FOXO_KO.3 4.2727 0.3882 99.9 2581.208 2580.211 -2.5 229813.8FOXO_KO.3 4.9412 0.3209 99.9 2709.309 2708.306 -0.4 133055.8FOXO_KO.1 2.6195 0.3743 99.9 1268.584 1268.587 -1.7 310800.4

IPI:IPI00 2 3 12.60% 198 21231 9.5 U Tax_Id=10090 Gene_Symbol=LOC100047092 similar to Heat shock protein 1 IPI:IPI00 2 3 17.60% 142 15271 9.9 U Tax_Id=10090 Gene_Symbol=Hspd1 15 kDa protein IPI:IPI00 2 3 12.40% 202 21501 9.8 U Tax_Id=10090 Gene_Symbol=Hspd1 22 kDa protein

FOXO_KO.1 5.5768 0.461 100 2562.248 2560.249 -2.9 32572.7FOXO_KO.1 4.5723 0.4054 100 2562.251 2560.249 -1.6 125304.6

IPI:IPI004 1 1 12.60% 135 14752 9.4 U Tax_Id=10090 Gene_Symbol=Stk38 Putative uncharacterized protein (Fragment) FOXO_KO.3 4.5282 0.3322 100 2064.025 2063.019 1.1 135024

IPI:IPI00 2 2 12.60% 119 13373 9.9 U Tax_Id=10090 Gene_Symbol=Rps20 40S ribosomal protein S20 * FOXO_KO.9 3.6047 0.3814 100 1648.865 1648.865 0 210116.9* FOXO_KO.9 3.6307 0.2987 99.9 1649.87 1648.865 0.6 378327.7IPI:IPI00 5 6 12.50% 586 63964 8.1 U Tax_Id=10090 Gene_Symbol=Hnrnpl Heterogeneous nuclear ribonucleoprotein L IPI:IPI00 5 6 12.30% 592 64076 7.5 U Tax_Id=10090 Gene_Symbol=Hnrnpl Putative uncharacterized protein

FOXO_KO.6 4.34 0.4568 100 3088.638 3087.632 0.6 7613.7FOXO_KO.6 6.3441 0.5629 100 3089.638 3087.632 -0.2 79344.5FOXO_KO.6 7.4 0.5366 100 3088.638 3087.632 0.9 182842.8FOXO_KO.1 3.9772 0.3127 99.9 2891.263 2890.262 -0.7 138741.8FOXO_KO.1 5.5323 0.5922 100 1867.866 1867.868 -0.9 94038

IPI:IPI00 5 5 12.50% 530 56963 9.2 U Tax_Id=10090 Gene_Symbol=Ptbp1 Putative uncharacterized protein IPI:IPI00 5 5 11.90% 555 59322 9.2 U Tax_Id=10090 Gene_Symbol=Ptbp1 polypyrimidine tract binding protein 1 isoform 1

FOXO_KO.3 3.2616 0.2887 99.7 2087.148 2086.143 1 109512.6FOXO_KO.1 5.3042 0.4978 100 2116.988 2116.989 -0.6 49265FOXO_KO.1 2.8908 0.27 99.5 2116.99 2116.989 0.3 137424.6FOXO_KO_w 2.477 0.324 99.8 1031.49 1031.491 -0.7 101686.3FOXO_KO.3 3.9508 0.2988 99.9 2981.515 2980.505 2.1 113157.8

IPI:IPI00 3 4 12.50% 425 46646 6.9 U Tax_Id=10090 Gene_Symbol=Plin2 adipose differentiation related protein FOXO_KO.1 3.9712 0.2327 99.9 1263.641 1263.643 -1.4 277906.1FOXO_KO.3 5.578 0.4668 100 2514.227 2512.216 1.5 37421.8FOXO_KO.1 6.2262 0.3857 100 2249.946 2248.941 0.7 50468.6

IPI:IPI00 2 2 12.50% 417 46416 5.8 U Tax_Id=10090 Gene_Symbol=Txndc5 Thioredoxin domain-containing protein 5

* FOXO_KO.4 3.4413 0.26 99.5 3822.823 3821.821 -0.4 13719* FOXO_KO.2 4.6616 0.4854 100 2109.982 2108.981 -1 139670.5IPI:IPI00 1 1 12.50% 128 14728 9.8 U Tax_Id=10090 Gene_Symbol=2810422J05Rik;Gm11808;Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 contamina 1 1 21.10% 76 8565 7.2 U no descriptionIPI:IPI00 1 1 10.50% 153 17225 6.2 U Tax_Id=10090 Gene_Symbol=Gm1821 Putative uncharacterized protein IPI:IPI00 1 1 8.00% 201 22592 7.4 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc 23 kDa protein IPI:IPI00 1 1 6.80% 236 26620 8.2 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc Ubiquitin B IPI:IPI00 1 1 16.70% 96 10914 8 U Tax_Id=10090 Gene_Symbol=2810422J05Rik Ubiquitin A-52 residue ribosomal protein fusion product 1 IPI:IPI00 1 1 6.90% 232 26856 9.8 U Tax_Id=10090 Gene_Symbol=2810422J05Rik 27 kDa protein IPI:IPI00 1 1 8.30% 193 22234 9.2 U Tax_Id=10090 Gene_Symbol=2810422J05Rik 22 kDa protein IPI:IPI008 1 1 12.50% 128 14711 9.8 U Tax_Id=10090 Gene_Symbol=Gm11517 similar to ubiquitin A-52 residue ribosomal protein fusion product 1 isoform 1 IPI:IPI007 1 1 12.50% 128 14666 9.7 U Tax_Id=10090 Gene_Symbol=Gm7808 similar to ubiquitin A-52 residue ribosomal protein fusion product 1 IPI:IPI00 1 1 2.20% 734 82550 8.6 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc ubiquitin C IPI:IPI00 1 1 2.70% 582 65457 8.7 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc;Gm4802;LOC100048105 Ubc protein IPI:IPI003 1 1 13.60% 118 13538 10.1 U Tax_Id=10090 Gene_Symbol=Gm13215 similar to fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a IPI:IPI00 1 1 5.20% 305 34369 7.5 U Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc Ubiquitin B

FOXO_KO.2 5.5921 0.3943 100 1788.93 1787.927 -0.2 625230.5IPI:IPI001 10 12 12.40% 1153 133367 7.6 U Tax_Id=10090 Gene_Symbol=Jak1 Tyrosine-protein kinase JAK1 IPI:IPI00 10 12 12.40% 1153 133353 7.5 U Tax_Id=10090 Gene_Symbol=Jak1 Janus kinase 1

FOXO_KO.3 5.6939 0.4818 100 3063.37 3063.368 0.6 93004.1FOXO_KO.1 8.334 0.5706 100 2412.159 2411.161 -2.2 66739.2FOXO_KO.1 3.7651 0.322 99.9 2411.158 2411.161 -1.2 194684FOXO_KO.5 6.3778 0.4911 100 2578.214 2576.216 -3.2 37397.9FOXO_KO.2 3.4101 0.3091 99.9 1543.746 1543.746 -0.4 180082.9FOXO_KO.1 5.5775 0.4904 100 1870.94 1870.939 0.3 119155.2FOXO_KO.1 4.8141 0.3567 99.9 3381.653 3380.649 0.2 67652FOXO_KO.1 3.7108 0.3403 99.9 3538.747 3536.75 -2.8 46115.2FOXO_KO.9 3.3109 0.2563 99.8 1621.733 1621.734 -0.7 227223.7FOXO_KO.9 4.4818 0.451 100 1846.886 1845.887 -2.3 262777.4

IPI:IPI00 7 9 12.40% 942 106522 5.7 U Tax_Id=10090 Gene_Symbol=Morc3 microrchidia 3 * FOXO_KO.1 4.4054 0.3495 100 1891.877 1890.887 -6.7 133279.1* FOXO_KO.1 3.008 0.3502 99.9 1890.884 1890.887 -1.5 241992* FOXO_KO.2 3.7693 0.3034 99.9 1729.882 1728.88 -0.7 119498.2* FOXO_KO.1 4.7072 0.4473 100 2430.043 2429.045 -2.2 62696* FOXO_KO.2 4.8445 0.3607 99.9 4271.11 4269.105 -0.2 71844.2* FOXO_KO.3 5.4557 0.4691 100 1753.814 1752.811 -0.1 157655.4* FOXO_KO.2 5.5624 0.3027 100 1749.912 1748.907 1.4 166049.4IPI:IPI00 2 3 12.40% 442 48163 5.2 U Tax_Id=10090 Gene_Symbol=Sqstm1 Isoform 1 of Sequestosome-1 IPI:IPI00 2 3 13.60% 404 44192 5.4 U Tax_Id=10090 Gene_Symbol=Sqstm1 Isoform 2 of Sequestosome-1

FOXO_KO.2 5.359 0.4634 100 2612.126 2612.118 2.9 31916.8FOXO_KO.2 4.2942 0.4205 100 3444.401 3443.404 -1.7 16707.7

IPI:IPI00 4 5 12.40% 362 43131 9.1 U Tax_Id=10090 Gene_Symbol=Ptplad1 Protein tyrosine phosphatase-like protein PTPLAD1 * FOXO_KO.3 5.3694 0.4446 100 2651.319 2651.314 1.9 141095.5* FOXO_KO.3 4.2267 0.4033 99.9 2822.368 2821.361 1.2 98893* FOXO_KO.2 3.4615 0.4326 100 1493.655 1493.658 -1.6 189606.5* FOXO_KO.2 3.103 0.3369 99.9 1573.622 1573.624 -1.6 202682.4IPI:IPI00 4 11 12.40% 249 28527 10.6 U Tax_Id=10090 Gene_Symbol=Gm16409 hypothetical protein isoform 1 IPI:IPI006 4 11 12.40% 249 28558 10.6 U Tax_Id=10090 Gene_Symbol=- hypothetical protein isoform 1

FOXO_KO.7 3.1571 0.1819 99.8 988.4929 988.4945 -1.6 106240.6FOXO_KO_w 2.1223 0.4616 99.9 1116.589 1116.59 -0.1 111205.1FOXO_KO.1 4.1138 0.3652 100 1280.647 1280.648 -0.6 33738FOXO_KO_w 2.5574 0.3274 99.8 1365.627 1365.629 -1.5 68875.6

IPI:IPI00 2 7 12.40% 145 17150 10.1 U Tax_Id=10090 Gene_Symbol=Gm4805 similar to ribosomal protein L26 IPI:IPI00 2 7 17.50% 103 12217 10.9 U Tax_Id=10090 Gene_Symbol=Rpl26 Ribosomal protein L26

FOXO_KO.1 2.6118 0.239 99.6 1082.525 1082.527 -1.1 327202.9FOXO_KO.1 2.9512 0.2233 99.8 1087.573 1087.574 -1.6 215080.4

IPI:IPI00 1 1 12.40% 105 11675 4.9 U Tax_Id=10090 Gene_Symbol=Txn1 Thioredoxin * FOXO_KO.1 4.1373 0.4661 100 1320.642 1320.643 -0.7 343223.3IPI:IPI00 4 4 12.30% 277 31112 10.3 U Tax_Id=10090 Gene_Symbol=Gm4978 hypothetical protein

FOXO_KO.1 3.9327 0.4417 100 1345.731 1345.732 -0.7 236899.1FOXO_KO.1 4.595 0.3416 99.9 2270.148 2269.149 -1.8 170991FOXO_KO.1 3.9658 0.3856 100 1700.776 1700.78 -1.9 354713.2FOXO_KO.1 5.6731 0.6061 100 2141.05 2141.054 -2.1 62213.7

IPI:IPI00 5 9 12.30% 285 30831 7.9 U Tax_Id=10090 Gene_Symbol=Hnrnpab Heterogeneous nuclear ribonucleoprotein A/B IPI:IPI00 5 9 11.30% 311 33816 5.8 U Tax_Id=10090 Gene_Symbol=Hnrnpab Hnrpab protein IPI:IPI00 5 9 10.50% 332 36211 6.9 U Tax_Id=10090 Gene_Symbol=Hnrnpab heterogeneous nuclear ribonucleoprotein A/B isoform 1

FOXO_KO.4 3.8584 0.2978 99.9 3951.032 3949.027 -0.3 25555.5FOXO_KO.3 4.2976 0.3203 100 2465.282 2464.276 0.9 25002.3FOXO_KO.3 4.4779 0.3445 99.9 2465.28 2464.276 0.1 183688.3FOXO_KO.3 5.9992 0.388 100 2197.1 2195.091 1.1 70395FOXO_KO.3 5.2351 0.2998 99.9 2197.099 2195.091 0.6 262383

IPI:IPI00 1 1 12.30% 138 16014 7.2 U Tax_Id=10090 Gene_Symbol=Cald1 16 kDa protein FOXO_KO.3 4.6917 0.381 100 1643.786 1643.787 -0.7 26534.5

IPI:IPI00 4 5 12.20% 729 79249 4.8 U Tax_Id=10090 Gene_Symbol=Lrrfip1 Isoform 1 of Leucine-rich repeat flightless-interacting protein 1 FOXO_KO.1 3.2566 0.236 99.8 1389.71 1389.711 -0.7 175482FOXO_KO.3 4.032 0.4134 100 1803.88 1803.879 0.2 146258.9FOXO_KO.2 5.2256 0.3466 99.9 3261.515 3260.511 0.2 61589.3FOXO_KO.1 5.782 0.4492 100 3074.431 3073.43 -0.9 147489.4

IPI:IPI00 5 10 12.20% 508 56823 8.4 U Tax_Id=10090 Gene_Symbol=Hmgcs2 Hydroxymethylglutaryl-CoA synthase, mitochondrial * FOXO_KO.4 4.8284 0.4361 100 2627.337 2626.329 2 37466.5* FOXO_KO.4 4.35 0.3917 99.9 2627.334 2626.329 0.7 123484

FOXO_KO.1 3.2874 0.4323 100 1217.661 1217.662 -1.1 298965.8* FOXO_KO.1 5.1987 0.377 100 1753.903 1752.901 -0.9 138306.2* FOXO_KO.2 4.449 0.4896 100 1611.716 1611.714 1 178550.1IPI:IPI00 3 4 12.20% 476 53451 6.1 U Tax_Id=10090 Gene_Symbol=Zfp622 Zinc finger protein 622 * FOXO_KO.4 6.5075 0.556 100 2113.956 2112.955 -0.9 85530.9* FOXO_KO.1 3.4213 0.3316 99.9 2444.116 2443.115 -1.1 161897.1* FOXO_KO.2 5.7624 0.3623 100 2062.985 2061.983 -0.6 118008.5IPI:IPI00 4 5 12.20% 451 50396 5.5 U Tax_Id=10090 Gene_Symbol=Psmc3 Putative uncharacterized protein IPI:IPI00 4 5 12.40% 442 49549 5.2 U Tax_Id=10090 Gene_Symbol=Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 IPI:IPI00 4 5 27.10% 203 22946 4.7 U Tax_Id=10090 Gene_Symbol=Psmc3 Protein IPI:IPI00 4 5 13.80% 400 44669 5 U Tax_Id=10090 Gene_Symbol=Psmc3 Proteasome (Prosome, macropain) 26S subunit ATPase 3


IPI:IPI00 3 4 12.20% 451 50136 5.1 U Tax_Id=10090 Gene_Symbol=Tuba1a Tubulin alpha-1A chain IPI:IPI00 3 4 12.20% 449 49909 5.1 U Tax_Id=10090 Gene_Symbol=Tuba1c Tubulin alpha-1C chain IPI:IPI00 3 4 12.20% 451 50152 5.1 U Tax_Id=10090 Gene_Symbol=Tuba1b Tubulin alpha-1B chain

FOXO_KO.2 4.5509 0.5166 100 2007.894 2007.893 0.4 80478FOXO_KO.3 4.3256 0.3804 100 1701.906 1701.906 -0.1 280178.4FOXO_KO.2 6.2379 0.5428 100 2332.023 2330.018 -0.8 163114

IPI:IPI00 2 3 12.20% 376 42004 5.5 U Tax_Id=10090 Gene_Symbol=Actbl2 Beta-actin-like protein 2 FOXO_KO.2 5.4972 0.4231 100 3185.618 3183.614 -1 138736.3FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2

IPI:IPI00 5 5 12.20% 287 32599 6.3 U Tax_Id=10090 Gene_Symbol=LOC100048867 similar to Annexin A2 IPI:IPI00 5 5 17.90% 196 21857 5.4 U Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2

FOXO_KO.2 5.1619 0.3489 100 1812.869 1811.866 0.1 286947.7FOXO_KO.2 3.2203 0.386 99.9 1811.867 1811.866 0.8 156617.8FOXO_KO.2 3.41 0.2378 99.8 1939.954 1939.961 -3.6 118465.2FOXO_KO.2 5.5544 0.389 100 2065.986 2064.983 -0.3 118008.7FOXO_KO.2 5.0381 0.3067 99.9 2065.985 2064.983 -0.6 562348.2

IPI:IPI00 2 2 12.20% 221 25360 8.7 U Tax_Id=10090 Gene_Symbol=Gsta3 Glutathione S-transferase A3 * FOXO_KO.5 4.7733 0.2767 99.9 3022.624 3021.618 0.7 44591.6* FOXO_KO.5 4.921 0.3827 100 3022.627 3021.618 1.9 77488.8IPI:IPI00 2 2 12.20% 229 24796 8.3 U Tax_Id=10090 Gene_Symbol=Cfl1 Putative uncharacterized protein IPI:IPI00 2 2 16.90% 166 18560 8.1 U Tax_Id=10090 Gene_Symbol=Cfl1 Cofilin-1 IPI:IPI00 2 2 16.90% 166 18514 7.8 U Tax_Id=10090 Gene_Symbol=LOC100048522 similar to Cofilin-1

FOXO_KO.3 5.4839 0.533 100 3093.609 3092.604 0.7 21282.8FOXO_KO.3 3.8949 0.2212 99.5 3093.605 3092.604 -0.8 66588

IPI:IPI00 12 16 12.10% 1500 164617 6.9 U Tax_Id=10090 Gene_Symbol=Cps1 Carbamoyl-phosphate synthase [ammonia], mitochondrial FOXO_KO.2 5.4479 0.4853 100 1724.817 1723.817 -2.3 341398.8FOXO_KO.2 4.1805 0.4555 100 2808.412 2807.41 -0.5 29533FOXO_KO.3 5.0333 0.3921 100 2809.396 2807.41 -7.4 109982.7FOXO_KO.2 4.4864 0.5483 100 1607.795 1607.794 0.6 159201.4FOXO_KO.3 4.6787 0.4339 100 3167.595 3166.594 -0.6 118459.2FOXO_KO.3 5.8447 0.4131 100 1609.802 1607.799 -1.9 495120.2FOXO_KO.1 3.861 0.5246 100 1420.694 1420.691 1.5 190826.5FOXO_KO.2 5.7871 0.4789 100 3737.738 3736.736 -0.3 37567.3

* FOXO_KO.1 6.055 0.4306 100 1978.964 1978.965 -0.7 273126.1* FOXO_KO.2 4.4652 0.3468 99.9 3742.872 3741.875 -1.7 39991.7* FOXO_KO.2 4.1852 0.2302 99.7 3742.881 3741.875 0.7 50137.3* FOXO_KO.2 5.8021 0.4261 100 1727.902 1726.897 1.2 151351.3IPI:IPI00 7 12 12.10% 767 90876 9.3 U Tax_Id=10090 Gene_Symbol=Top1 DNA topoisomerase 1 IPI:IPI00 7 12 12.30% 758 89739 9.4 U Tax_Id=10090 Gene_Symbol=Top1 Putative uncharacterized protein

FOXO_KO.1 4.9952 0.4294 100 2701.385 2700.388 -2.4 143663.9FOXO_KO.1 3.8831 0.3619 99.9 2701.394 2700.388 1.1 272704.7FOXO_KO.2 4.1283 0.1916 99.8 1464.695 1464.696 -0.8 73027.3FOXO_KO.1 4.6566 0.3251 100 1622.767 1621.765 -0.6 171546.5FOXO_KO.2 6.9344 0.5179 100 2813.37 2811.362 0.2 190241.8FOXO_KO.2 6.4308 0.4127 100 3284.606 3282.606 -2.3 67894.2FOXO_KO.2 6.7476 0.4069 100 2253.067 2252.065 -0.7 82243.9

IPI:IPI001 7 12 12.10% 659 75483 9.3 U Tax_Id=10090 Gene_Symbol=Abcd3 ATP-binding cassette sub-family D member 3 IPI:IPI00 7 12 12.10% 659 75475 9.3 U Tax_Id=10090 Gene_Symbol=Abcd3 ATP-binding cassette, sub-family D, member 3

FOXO_KO.3 4.7918 0.4173 100 2598.332 2596.341 -5.8 17988.4FOXO_KO_w 4.0526 0.3098 100 1534.742 1534.738 2.1 131677.5FOXO_KO_w 2.4747 0.3605 99.9 1535.74 1534.738 -1.3 70312.2FOXO_KO.2 4.5588 0.4093 100 1698.877 1698.881 -2.4 166303.8FOXO_KO.4 6.2572 0.49 100 2095.906 2094.907 -2.2 117270.6FOXO_KO.4 3.5443 0.2986 99.9 2095.911 2094.907 0.3 68994.7FOXO_KO.1 2.8492 0.5148 100 1225.593 1225.595 -1.3 254327.6

IPI:IPI00 3 3 12.10% 504 57633 9.1 U Tax_Id=10090 Gene_Symbol=Epb4.1l5 Isoform 2 of Band 4.1-like protein 5 IPI:IPI008 3 3 8.30% 739 82590 6.5 U Tax_Id=10090 Gene_Symbol=Epb4.1l5 Isoform 3 of Band 4.1-like protein 5 IPI:IPI00 3 3 8.30% 731 81635 6.4 U Tax_Id=10090 Gene_Symbol=Epb4.1l5 Isoform 1 of Band 4.1-like protein 5

FOXO_KO.5 3.9978 0.44 100 2804.353 2802.344 0.6 30216.9FOXO_KO.3 3.7388 0.4935 100 1923.98 1923.977 1.5 131651.3FOXO_KO.3 4.9 0.4892 100 2312.128 2312.129 -0.4 50875.7

IPI:IPI00 1 2 12.10% 257 28025 11 U Tax_Id=10090 Gene_Symbol=Rpl8 60S ribosomal protein L8 * FOXO_KO.3 5.3595 0.4653 100 3397.711 3395.712 -2.2 101717.8IPI:IPI00 1 1 12.10% 165 18370 8.8 U Tax_Id=10090 Gene_Symbol=Pin1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 IPI:IPI00 1 1 12.60% 159 17993 8.8 U Tax_Id=10090 Gene_Symbol=Pin1l MCG20568

FOXO_KO.2 5.5543 0.5518 100 2180.892 2180.892 -0.3 63850.8IPI:IPI00 3 4 12.00% 440 49185 6.2 U Tax_Id=10090 Gene_Symbol=Psmc1 26S protease regulatory subunit 4 * FOXO_KO.5 4.5265 0.4335 100 2044.957 2044.96 -1.6 55425.2* FOXO_KO.2 4.1364 0.3962 99.9 2588.288 2586.28 0.5 140281* FOXO_KO.4 5.4803 0.4613 100 1752.865 1751.863 -0.8 106429.2IPI:IPI00 3 3 12.00% 274 31053 7.2 U Tax_Id=10090 Gene_Symbol=Prdx4 Peroxiredoxin-4

FOXO_KO.1 6.0537 0.4473 100 2171.926 2170.925 -0.8 98177.2FOXO_KO.1 3.4648 0.3405 99.9 2170.919 2170.925 -2.5 208555.3FOXO_KO.1 4.9013 0.5043 100 1624.759 1624.76 -0.5 305191.6

IPI:IPI00 2 2 12.00% 191 20994 9.5 U Tax_Id=10090 Gene_Symbol=Rps3 21 kDa protein FOXO_KO.1 2.3075 0.2913 99.7 1092.568 1092.568 -0.3 302582.8FOXO_KO.2 3.8121 0.5128 100 1572.755 1572.758 -2.3 156609.7

IPI:IPI00 1 1 12.00% 108 12097 9.1 U Tax_Id=10090 Gene_Symbol=Cisd1 CDGSH iron sulfur domain-containing protein 1 * FOXO_KO.1 3.8075 0.5193 100 1475.68 1475.684 -2.1 253706.2IPI:IPI00 8 9 11.90% 1344 152036 9 U Tax_Id=10090 Gene_Symbol=Mybbp1a Myb-binding protein 1A

FOXO_KO.5 5.4521 0.4145 100 3422.712 3420.707 -0.5 69317.3FOXO_KO.5 4.3419 0.3225 100 2259.206 2258.199 1.6 68941.2

* FOXO_KO.3 4.6846 0.4472 100 2284.101 2283.096 0.5 53875.3* FOXO_KO.5 4.7169 0.4207 100 3480.58 3480.578 0.6 36790.9* FOXO_KO.2 6.4087 0.5393 100 2693.175 2692.179 -2.8 47056.5* FOXO_KO.2 5.4472 0.4401 100 2693.175 2692.179 -2.9 545147.1

FOXO_KO.5 5.119 0.4771 100 2206.075 2205.09 -8.1 77397.1FOXO_KO.9 3.7403 0.4041 100 1632.768 1631.768 -1.5 209944.2

IPI:IPI00 5 5 11.90% 477 55396 5.6 U Tax_Id=10090 Gene_Symbol=Spna2 Spectrin alpha 2 FOXO_KO.3 4.6732 0.4295 100 2426.129 2426.126 1.1 39542.7FOXO_KO.3 6.2554 0.5786 100 2299.036 2298.031 0.7 69892.7FOXO_KO.2 4.7119 0.3973 100 1951.936 1951.936 0.4 90429.8FOXO_KO.3 8.2121 0.4873 100 1974.028 1973.026 -0.6 160792.1FOXO_KO.3 4.1812 0.1874 99.5 1974.027 1973.026 -1.2 188084.7

IPI:IPI00 2 3 11.90% 218 24470 5.3 U Tax_Id=10090 Gene_Symbol=Kctd17 Kctd17 protein * FOXO_KO.3 7.0113 0.5188 100 2965.514 2963.507 0.1 27388.8

* FOXO_KO.3 3.7836 0.3033 99.9 2965.515 2963.507 0.5 152767.8IPI:IPI00 2 2 11.90% 201 21708 9.3 U Tax_Id=10090 Gene_Symbol=Mrpl12 39S ribosomal protein L12, mitochondrial * FOXO_KO.6 4.274 0.316 100 2710.534 2709.528 0.7 8373.1* FOXO_KO.6 5.3062 0.4396 100 2710.534 2709.528 0.8 141181.4IPI:IPI00 2 2 11.90% 168 19667 8.4 U Tax_Id=10090 Gene_Symbol=Arpc4 Actin-related protein 2/3 complex subunit 4 IPI:IPI00 2 2 11.90% 168 19708 8.8 U Tax_Id=10090 Gene_Symbol=Arpc4 Putative uncharacterized protein IPI:IPI00 2 2 25.60% 78 9552 7.5 U Tax_Id=10090 Gene_Symbol=Arpc4 actin related protein 2/3 complex, subunit 4 isoform 3

FOXO_KO.5 6.0994 0.4457 100 2453.218 2452.214 0.4 22030.7FOXO_KO.5 5.9763 0.483 100 2453.217 2452.214 -0.3 109984.7

IPI:IPI00 1 2 11.90% 134 14983 5.9 U Tax_Id=10090 Gene_Symbol=Actb Beta-actin FE-3 (Fragment) FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2

IPI:IPI00 1 2 11.90% 126 13936 10.3 U Tax_Id=10090 Gene_Symbol=Hist1h2bf;Hist1h2bl;Hist1h2bn;LOC100046213;Hist1h2bj Histone H2B type 1-F/J/L IPI:IPI00 1 2 11.20% 134 14821 10.4 U Tax_Id=10090 Gene_Symbol=- 15 kDa protein IPI:IPI00 1 2 11.20% 134 14911 10.2 U Tax_Id=10090 Gene_Symbol=- 15 kDa protein IPI:IPI00 1 2 11.70% 128 14156 10.3 U Tax_Id=10090 Gene_Symbol=- 14 kDa protein IPI:IPI00 1 2 11.70% 128 14134 10.3 U Tax_Id=10090 Gene_Symbol=- 14 kDa protein IPI:IPI00 1 2 11.20% 134 14815 10.4 U Tax_Id=10090 Gene_Symbol=Hist1h2bk 15 kDa protein IPI:IPI00 1 2 11.20% 134 14909 10.4 U Tax_Id=10090 Gene_Symbol=Hist1h2bh 15 kDa protein IPI:IPI00 1 2 11.60% 129 14194 10.2 U Tax_Id=10090 Gene_Symbol=Hist1h2bk 14 kDa protein IPI:IPI00 1 2 11.20% 134 14903 10.3 U Tax_Id=10090 Gene_Symbol=- 15 kDa protein IPI:IPI00 1 2 11.20% 134 14796 10.3 U Tax_Id=10090 Gene_Symbol=- 15 kDa protein IPI:IPI00 1 2 11.20% 134 14755 10.4 U Tax_Id=10090 Gene_Symbol=Hist1h2bm 15 kDa protein IPI:IPI00 1 2 10.90% 138 15565 10.2 U Tax_Id=10090 Gene_Symbol=Hist1h2bp Isoform 2 of Histone H2B type 1-P IPI:IPI00 1 2 11.90% 126 13992 10.3 U Tax_Id=10090 Gene_Symbol=Hist1h2bp Isoform 1 of Histone H2B type 1-P IPI:IPI00 1 2 11.90% 126 13952 10.3 U Tax_Id=10090 Gene_Symbol=Hist1h2bb Histone H2B type 1-B IPI:IPI00 1 2 11.90% 126 13994 10.4 U Tax_Id=10090 Gene_Symbol=Hist3h2ba Histone H2B type 3-A IPI:IPI00 1 2 11.10% 135 14939 10.1 U Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B IPI:IPI00 1 2 10.40% 144 15920 10.5 U Tax_Id=10090 Gene_Symbol=Hist1h2bp 16 kDa protein IPI:IPI00 1 2 11.90% 126 13920 10.3 U Tax_Id=10090 Gene_Symbol=Hist2h2bb Histone H2B type 2-B IPI:IPI00 1 2 11.90% 126 13936 10.3 U Tax_Id=10090 Gene_Symbol=Hist1h2bm Histone H2B type 1-M IPI:IPI00 1 2 11.90% 126 13906 10.3 U Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B type 1-C/E/G IPI:IPI00 1 2 11.90% 126 13920 10.3 U Tax_Id=10090 Gene_Symbol=Hist1h2bk Histone H2B type 1-K IPI:IPI00 1 2 9.70% 154 17145 10.1 U Tax_Id=10090 Gene_Symbol=Hist3h2bb histone cluster 3, H2bb IPI:IPI00 1 2 11.90% 126 13920 10.3 U Tax_Id=10090 Gene_Symbol=Hist1h2bh Histone H2B type 1-H IPI:IPI00 1 2 11.90% 126 13993 10.3 U Tax_Id=10090 Gene_Symbol=Hist2h2be Histone H2B type 2-E IPI:IPI00 1 2 11.20% 134 14888 10.4 U Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B IPI:IPI00 1 2 12.50% 120 13310 10.3 U Tax_Id=10090 Gene_Symbol=Hist2h2bb Hist2h2bb protein

FOXO_KO.4 5.7458 0.4941 100 1744.827 1743.819 2.7 272720.6IPI:IPI00 3 5 11.80% 660 74181 9.5 U Tax_Id=10090 Gene_Symbol=Ddx18 ATP-dependent RNA helicase DDX18 * FOXO_KO.1 6.2805 0.5489 100 2333.059 2332.061 -2.2 53362.1* FOXO_KO.2 5.0693 0.4853 100 3311.57 3310.567 -0.3 54692.2

FOXO_KO.3 4.5456 0.4496 100 3009.464 3009.463 0.4 107463.9IPI:IPI00 1 2 11.80% 255 28944 8.3 U Tax_Id=10090 Gene_Symbol=Sco2 Protein SCO2 homolog, mitochondrial * FOXO_KO.3 3.7599 0.3715 99.9 3336.742 3334.735 0.1 98134.2IPI:IPI00 1 1 11.80% 161 18127 6.8 U Tax_Id=10090 Gene_Symbol=Ppil3 Isoform 1 of Peptidyl-prolyl cis-trans isomerase-like 3 * FOXO_KO.3 2.9767 0.2833 99.6 2155.16 2154.154 1 117792.7IPI:IPI003 5 9 11.70% 554 62515 6.2 U Tax_Id=10090 Gene_Symbol=Ephx2 Isoform 1 of Epoxide hydrolase 2 * FOXO_KO.3 6.0531 0.4278 100 2415.162 2414.158 0.2 68346.2

* FOXO_KO.3 4.4372 0.3754 99.9 2414.15 2414.158 -3.5 129738.8FOXO_KO.4 6.338 0.5374 100 2377.05 2375.042 0.5 109994FOXO_KO.3 5.0663 0.3758 100 2673.336 2671.329 0 54185.2FOXO_KO.3 3.8529 0.2647 99.8 2672.338 2671.329 2.1 108549.1

IPI:IPI00 4 4 11.70% 494 54853 6.5 U Tax_Id=10090 Gene_Symbol=Mccc1 Putative uncharacterized protein FOXO_KO.2 4.4141 0.2657 99.9 3071.36 3070.359 -0.9 72101FOXO_KO.1 4.4132 0.3511 100 1412.7 1410.693 0.2 281373.8FOXO_KO.1 3.3229 0.375 100 1282.596 1282.598 -1.8 418736.2FOXO_KO.2 3.449 0.4573 100 2035.058 2035.061 -1.4 154083

IPI:IPI00 3 3 11.70% 412 46050 9.2 U Tax_Id=10090 Gene_Symbol=Tmpo thymopoietin isoform delta IPI:IPI00 3 3 6.90% 693 75168 8 U Tax_Id=10090 Gene_Symbol=Tmpo thymopoietin isoform alpha IPI:IPI00 3 3 10.60% 452 50373 9.4 U Tax_Id=10090 Gene_Symbol=Tmpo thymopoietin isoform epsilon

FOXO_KO.1 3.9376 0.2723 99.8 2544.203 2543.201 -0.6 191231.3FOXO_KO.3 6.53 0.5165 100 2702.346 2701.341 0.4 26615.9FOXO_KO.3 4.3467 0.2526 99.9 2702.345 2701.341 0 129704

IPI:IPI001 2 2 11.70% 376 40704 4.8 U Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10A of 26S proteasome non-ATPase regulatory subunit 4 IPI:IPI002 2 2 12.60% 349 37964 5.4 U Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10D of 26S proteasome non-ATPase regulatory subunit 4

FOXO_KO.2 3.7369 0.3438 99.9 2207.091 2206.087 0 171113.4FOXO_KO.1 5.8058 0.543 100 2317.124 2316.12 0 88397.2

IPI:IPI003 1 1 11.70% 231 25054 6.1 U Tax_Id=10090 Gene_Symbol=Psmd10 26S proteasome non-ATPase regulatory subunit 10 IPI:IPI00 1 1 11.70% 231 25084 6.1 U Tax_Id=10090 Gene_Symbol=Psmd10 proteasome 26S non-ATPase subunit 10 isoform 1

FOXO_KO.1 4.2843 0.2395 99.7 3028.394 3027.396 -1.8 60004.4IPI:IPI00 1 2 11.70% 145 16168 4.7 U Tax_Id=10090 Gene_Symbol=Mcfd2 Multiple coagulation factor deficiency protein 2 homolog * FOXO_KO.1 4.4849 0.4356 100 1992.845 1992.846 -0.4 100146.8IPI:IPI00 1 2 11.70% 128 14920 11.4 U Tax_Id=10090 Gene_Symbol=Mrps14 28S ribosomal protein S14, mitochondrial IPI:IPI00 1 2 12.30% 122 14280 10.9 U Tax_Id=10090 Gene_Symbol=Mrps14 14 kDa protein

FOXO_KO.2 3.8552 0.3127 99.9 1629.798 1628.795 -0.3 175647.5IPI:IPI00 6 6 11.60% 870 96857 5.6 U Tax_Id=10090 Gene_Symbol=Mvp major vault protein * FOXO_KO.6 4.7122 0.4793 100 2691.454 2690.454 -1.2 15809.6* FOXO_KO.6 5.2338 0.5005 100 2691.453 2690.454 -1.6 149124.5* FOXO_KO.1 6.9539 0.5992 100 2264.096 2263.095 -0.8 55022.3* FOXO_KO.3 6.5539 0.5652 100 2175.114 2174.109 1 126869.9* FOXO_KO.3 4.506 0.4868 100 2210.032 2210.026 3 60548.7* FOXO_KO.1 5.3543 0.4866 100 1543.796 1543.796 -0.2 293220.3IPI:IPI00 4 6 11.60% 507 56625 9.1 U Tax_Id=10090 Gene_Symbol=Aldh3a2 Fatty aldehyde dehydrogenase variant form IPI:IPI00 4 6 12.20% 484 53971 8.4 U Tax_Id=10090 Gene_Symbol=Aldh3a2 Putative uncharacterized protein IPI:IPI00 4 6 12.10% 487 54330 8.5 U Tax_Id=10090 Gene_Symbol=Aldh3a2 Aldehyde dehydrogenase family 3, subfamily A2 IPI:IPI00 4 6 11.10% 532 59277 8.1 U Tax_Id=10090 Gene_Symbol=Aldh3a2 Aldehyde dehydrogenase family 3, subfamily A2 IPI:IPI00 4 6 13.80% 426 47683 5.9 U Tax_Id=10090 Gene_Symbol=Aldh3a2 Putative uncharacterized protein

FOXO_KO.6 4.3924 0.3275 99.9 3404.731 3402.725 -0.2 63221FOXO_KO.1 4.1281 0.3791 100 2015.841 2014.842 -2.1 46920.9FOXO_KO.1 3.442 0.3378 99.9 2014.838 2014.842 -1.9 217695.6FOXO_KO.2 3.333 0.4319 100 1419.692 1419.686 4 162615.6

IPI:IPI00 3 4 11.60% 483 55844 4.8 U Tax_Id=10090 Gene_Symbol=Ccdc47 Isoform 1 of Coiled-coil domain-containing protein 47 IPI:IPI00 3 4 25.00% 224 25841 8.6 U Tax_Id=10090 Gene_Symbol=Ccdc47 Coiled-coil domain containing 47 IPI:IPI006 3 4 11.70% 477 54865 4.7 U Tax_Id=10090 Gene_Symbol=Ccdc47 Isoform 2 of Coiled-coil domain-containing protein 47

FOXO_KO.1 4.3042 0.4109 100 1713.745 1713.746 -0.4 101979.3FOXO_KO.5 3.9185 0.5311 100 2587.198 2587.198 0.2 22125.6

FOXO_KO.5 3.0803 0.2363 99.6 2112.052 2112.043 4.6 28310.4IPI:IPI00 1 1 11.60% 301 33559 7.3 U Tax_Id=10090 Gene_Symbol=Hnrpdl Heterogeneous nuclear ribonucleoprotein D-like IPI:IPI00 1 1 8.30% 420 46270 9.6 U Tax_Id=10090 Gene_Symbol=Hnrpdl heterogeneous nuclear ribonucleoprotein D-like

FOXO_KO.4 3.4937 0.336 99.9 3891.879 3889.873 -0.1 21455.6IPI:IPI001 7 14 11.50% 636 70643 9.5 U Tax_Id=10090 Gene_Symbol=Pabpc1 Polyadenylate-binding protein 1 IPI:IPI00 7 14 11.50% 636 70671 9.5 U Tax_Id=10090 Gene_Symbol=Pabpc1 poly(A) binding protein, cytoplasmic 1

FOXO_KO.2 5.4185 0.3913 100 1928.912 1928.914 -0.9 183360.2FOXO_KO.1 5.0999 0.4851 100 1740.795 1740.798 -1.7 195266.7FOXO_KO.1 4.9454 0.3239 100 1470.641 1468.637 -1.9 900460FOXO_KO.2 6.5405 0.5147 100 2043.953 2042.949 0.5 100293.5FOXO_KO.2 2.6641 0.3323 99.7 2042.951 2042.949 1.3 121181.5FOXO_KO.4 6.0407 0.5297 100 2741.394 2740.389 0.6 25547.1FOXO_KO.4 3.6745 0.4621 100 2741.396 2740.389 1.3 45001.9

IPI:IPI00 4 7 11.50% 462 50114 9 U Tax_Id=10090 Gene_Symbol=Eef1a1 Elongation factor 1-alpha 1 IPI:IPI00 4 7 21.30% 249 27586 8.6 U Tax_Id=10090 Gene_Symbol=Eef1a1 28 kDa protein

FOXO_KO.1 4.7207 0.4242 100 1611.81 1610.809 -1.8 257581.1FOXO_KO.1 2.9504 0.3486 99.9 1610.807 1610.809 -1.3 232010.8FOXO_KO_w 3.2454 0.3006 99.9 1282.561 1282.562 -0.8 34817.7FOXO_KO.3 4.0888 0.1935 99.5 2995.559 2994.556 -0.4 115800.9

IPI:IPI00 2 2 11.50% 286 32804 6.5 U Tax_Id=10090 Gene_Symbol=Haao 3-hydroxyanthranilate 3,4-dioxygenase * FOXO_KO.2 4.7696 0.5658 100 1578.74 1577.737 -0.1 414146.8* FOXO_KO.4 3.4589 0.2304 99.5 2393.192 2392.193 -1.8 115953.7IPI:IPI00 1 1 11.50% 165 17912 9.3 U Tax_Id=10090 Gene_Symbol=Gm4957 similar to ribosomal protein L12 IPI:IPI008 1 1 13.40% 142 15780 7.5 U Tax_Id=10090 Gene_Symbol=LOC100046569;Gm12038 similar to ribosomal protein L12

FOXO_KO.1 4.3463 0.4458 100 2047.919 2046.919 -1.3 204660.3IPI:IPI004 1 1 11.50% 130 15069 10.9 U Tax_Id=10090 Gene_Symbol=Rps24 Isoform 2 of 40S ribosomal protein S24 IPI:IPI007 1 1 11.50% 131 15197 10.9 U Tax_Id=10090 Gene_Symbol=Rps24 Isoform 3 of 40S ribosomal protein S24 IPI:IPI004 1 1 11.20% 134 15551 10.8 U Tax_Id=10090 Gene_Symbol=Rps24;LOC677113 40S ribosomal protein S24

FOXO_KO.3 4.1435 0.4599 100 1681.777 1681.778 -0.2 228100.6IPI:IPI00 13 13 11.40% 1675 191555 5.7 U Tax_Id=10090 Gene_Symbol=Cltc Clathrin heavy chain 1 IPI:IPI00 13 13 11.40% 1679 191985 5.7 U Tax_Id=10090 Gene_Symbol=Cltc Clathrin, heavy polypeptide

FOXO_KO.1 4.5359 0.4243 100 1763.836 1763.837 -0.6 162817FOXO_KO.2 3.5577 0.3823 100 1707.857 1707.855 1.2 482043.5FOXO_KO.5 3.4686 0.3089 99.9 3072.507 3071.5 1.2 26428.1FOXO_KO.3 5.1003 0.3064 99.9 2368.26 2368.262 -0.9 166877.7FOXO_KO.3 4.3057 0.3294 99.9 2711.234 2710.23 0.2 81045.5FOXO_KO.2 4.1367 0.4358 100 2465.217 2464.221 -3 114070FOXO_KO.6 6.9449 0.3967 100 2056.05 2055.047 0.1 103809.6FOXO_KO.6 3.0872 0.3719 99.9 2056.048 2055.047 -0.8 141117.2FOXO_KO.3 5.5726 0.4328 100 2356.15 2355.146 0.2 90431.6FOXO_KO.4 5.519 0.4182 100 3389.613 3387.605 0.3 66911.9FOXO_KO.5 4.9122 0.4203 100 2121.039 2121.039 0.3 98810.4FOXO_KO.5 5.3997 0.4896 100 2122.047 2121.039 2.3 106149.7FOXO_KO.4 3.944 0.4115 100 2277.145 2277.14 2.5 74223.4

IPI:IPI00 1 1 11.40% 280 31654 4.9 U Tax_Id=10090 Gene_Symbol=Hax1 HCLS1-associated protein X-1 * FOXO_KO.4 5.3076 0.3911 100 3503.599 3501.59 0.5 74485.3IPI:IPI00 7 7 11.30% 802 92476 4.8 U Tax_Id=10090 Gene_Symbol=Hsp90b1 Endoplasmin * FOXO_KO.2 3.3264 0.2748 99.8 2729.338 2728.338 -1.4 41559.9

* FOXO_KO.2 4.2365 0.2107 99.6 2729.334 2728.338 -2.7 115749FOXO_KO.1 3.5135 0.3573 100 1275.642 1275.643 -0.5 477433.2FOXO_KO.2 3.7471 0.5007 100 1525.725 1525.727 -1.3 209186FOXO_KO.3 3.3502 0.2514 99.5 3077.491 3076.486 0.4 85160.6FOXO_KO.3 6.0152 0.6256 100 3233.592 3232.587 0.4 125543.2FOXO_KO.3 5.0228 0.4502 100 1864.913 1864.915 -1 193083.2

IPI:IPI004 5 5 11.30% 574 65446 6.8 U Tax_Id=10090 Gene_Symbol=Lmna Isoform C of Lamin-A/C IPI:IPI006 5 5 9.80% 665 74238 7 U Tax_Id=10090 Gene_Symbol=Lmna Isoform A of Lamin-A/C

FOXO_KO.1 5.1827 0.337 100 1630.811 1629.808 -0.1 172523.8FOXO_KO.1 3.0993 0.3274 99.9 1629.807 1629.808 -0.4 202908FOXO_KO.2 5.4697 0.4679 100 1893.927 1893.926 0.5 88153.6FOXO_KO.1 4.5171 0.4974 100 1605.81 1605.812 -1.4 211528.4FOXO_KO.1 3.7152 0.2887 99.9 2736.147 2735.148 -1.9 104483.2

IPI:IPI002 3 3 11.30% 462 52652 6.6 U Tax_Id=10090 Gene_Symbol=Lmna Isoform C2 of Lamin-A/C FOXO_KO.2 5.4697 0.4679 100 1893.927 1893.926 0.5 88153.6FOXO_KO.1 4.5171 0.4974 100 1605.81 1605.812 -1.4 211528.4FOXO_KO.1 3.7152 0.2887 99.9 2736.147 2735.148 -1.9 104483.2

IPI:IPI00 3 3 11.30% 373 43476 5.7 U Tax_Id=10090 Gene_Symbol=Hsp90b1 43 kDa protein FOXO_KO.3 3.3502 0.2514 99.5 3077.491 3076.486 0.4 85160.6FOXO_KO.3 6.0152 0.6256 100 3233.592 3232.587 0.4 125543.2FOXO_KO.3 5.0228 0.4502 100 1864.913 1864.915 -1 193083.2

IPI:IPI00 2 2 11.30% 337 35873 5.3 U Tax_Id=10090 Gene_Symbol=Flna 36 kDa protein FOXO_KO.1 3.6171 0.3557 99.9 2059.938 2057.935 -1.6 141976.9FOXO_KO.2 6.2665 0.514 100 2259.03 2258.028 -0.7 127394.2

IPI:IPI00 6 12 11.30% 301 32460 8.7 U Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Isoform 3 of Heterogeneous nuclear ribonucleoproteins A2/B1 IPI:IPI00 6 12 10.00% 341 35965 8.6 U Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Heterogeneous nuclear ribonucleoprotein A2/B1 IPI:IPI00 6 12 4.20% 814 87621 4.7 U Tax_Id=10090 Gene_Symbol=LOC100045191 similar to heterogeneous nuclear ribonucleoprotein A2/B1 IPI:IPI00 6 12 9.60% 353 37403 8.9 U Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Isoform 1 of Heterogeneous nuclear ribonucleoproteins A2/B1 IPI:IPI00 6 12 10.00% 341 35979 8.6 U Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Isoform 2 of Heterogeneous nuclear ribonucleoproteins A2/B1

FOXO_KO.1 2.6957 0.3731 100 1050.442 1050.441 0.5 369100.1FOXO_KO.3 6.2591 0.511 100 2222.078 2220.071 0.3 82772FOXO_KO.3 3.8844 0.2449 99.8 2222.073 2220.071 -1.9 111031.7FOXO_KO.2 3.8864 0.2957 100 1188.646 1188.647 -0.6 465957.8FOXO_KO.2 4.9512 0.4729 100 1852.868 1851.866 -0.8 281087.9FOXO_KO.2 5.0424 0.4141 100 1695.764 1695.765 -0.6 754161.2

IPI:IPI003 3 10 11.30% 186 21606 10 U Tax_Id=10090 Gene_Symbol=Gm6436 similar to ribosomal protein IPI:IPI006 3 10 12.70% 166 19062 9.9 U Tax_Id=10090 Gene_Symbol=EG630612 similar to ribosomal protein

FOXO_KO_w 3.9668 0.4067 100 1403.675 1403.676 -1 52628.2FOXO_KO_w 3.0781 0.3279 99.9 1403.672 1403.676 -2.9 77587.5FOXO_KO.3 4.3234 0.2871 99.9 2458.261 2456.256 -0.7 204156.6

IPI:IPI00 2 5 11.30% 195 21569 5.5 U Tax_Id=10090 Gene_Symbol=Actg2 22 kDa protein FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6

IPI:IPI00 1 2 11.30% 106 12648 8.9 U Tax_Id=10090 Gene_Symbol=Ndufs5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 IPI:IPI00 1 2 13.20% 91 10909 8.9 U Tax_Id=10090 Gene_Symbol=Ndufs5 NADH dehydrogenase (Ubiquinone) Fe-S protein 5

FOXO_KO.3 4.567 0.4145 100 1586.72 1585.72 -2.6 279777.5IPI:IPI001 6 8 11.20% 851 93582 9.1 U Tax_Id=10090 Gene_Symbol=Ddx21 Nucleolar RNA helicase 2 IPI:IPI00 6 8 11.20% 851 93551 9.1 U Tax_Id=10090 Gene_Symbol=Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

FOXO_KO.1 4.8427 0.4252 100 2004.941 2004.943 -1.2 93390.8FOXO_KO.9 7.0167 0.5602 100 1813.819 1812.817 -0.6 213082.6FOXO_KO.1 3.821 0.3594 99.9 1812.815 1812.817 -1 265353.4FOXO_KO.1 3.644 0.3844 100 2151.941 2151.94 0.5 65203.5FOXO_KO.1 4.0138 0.2855 99.9 1867.929 1866.944 -9.8 78392.4FOXO_KO.3 4.884 0.5168 100 2778.315 2776.304 1.6 17462.8

IPI:IPI00 5 8 11.20% 789 88230 8 U Tax_Id=10090 Gene_Symbol=Zc3hav1 Isoform 2 of Zinc finger CCCH-type antiviral protein 1 IPI:IPI00 5 8 13.10% 673 76412 7.8 U Tax_Id=10090 Gene_Symbol=Zc3hav1 Zc3hav1 protein

FOXO_KO.5 4.081 0.2846 99.9 2534.36 2532.352 0.7 26596.9FOXO_KO.5 3.8985 0.2742 99.9 2533.351 2532.352 -1.6 60093.9FOXO_KO.4 4.5086 0.429 100 3359.659 3357.649 0.8 92973.5FOXO_KO.2 4.2959 0.4774 100 1882.845 1882.845 -0.5 130026.6FOXO_KO.5 4.5521 0.4143 100 2662.254 2661.252 -0.4 28221.3

IPI:IPI00 4 4 11.20% 738 82671 9.8 U Tax_Id=10090 Gene_Symbol=Mybbp1a Putative uncharacterized protein FOXO_KO.5 5.4521 0.4145 100 3422.712 3420.707 -0.5 69317.3FOXO_KO.5 4.3419 0.3225 100 2259.206 2258.199 1.6 68941.2FOXO_KO.5 5.119 0.4771 100 2206.075 2205.09 -8.1 77397.1FOXO_KO.9 3.7403 0.4041 100 1632.768 1631.768 -1.5 209944.2

IPI:IPI00 4 5 11.20% 661 74635 8.5 U Tax_Id=10090 Gene_Symbol=Acox1 Peroxisomal acyl-coenzyme A oxidase 1 IPI:IPI00 4 5 11.20% 661 74649 8.5 U Tax_Id=10090 Gene_Symbol=Acox1 Acyl-Coenzyme A oxidase 1, palmitoyl, isoform CRA_a

FOXO_KO.3 4.2086 0.3947 100 2736.303 2735.295 1.7 12736.5FOXO_KO.3 3.5181 0.3958 100 1711.799 1711.804 -2.7 120949FOXO_KO.3 4.6914 0.4279 100 2506.323 2505.32 -0.1 157103.7FOXO_KO.3 4.5158 0.487 100 1747.8 1747.796 2 145366.3

IPI:IPI00 2 3 11.20% 482 55090 5.6 U Tax_Id=10090 Gene_Symbol=LOC100048437 similar to histone deacetylase isoform 1 IPI:IPI00 2 3 11.20% 482 55063 5.5 U Tax_Id=10090 Gene_Symbol=LOC100048437 similar to histone deacetylase isoform 2

FOXO_KO.6 6.7864 0.5791 100 2355.238 2354.231 1.6 45425FOXO_KO.2 4.7077 0.4216 100 3727.594 3725.598 -3 32301

IPI:IPI00 4 8 11.20% 473 54541 8.9 U Tax_Id=10090 Gene_Symbol=Nono Isoform 1 of Non-POU domain-containing octamer-binding protein FOXO_KO.5 6.653 0.4629 100 2670.337 2668.325 1.9 40286.4FOXO_KO.5 5.9591 0.5291 100 2669.329 2668.325 0.2 738237.7

* FOXO_KO.2 6.7309 0.5388 100 2141.997 2140.995 -1 144202.7* FOXO_KO.1 3.3777 0.3658 100 1336.622 1336.624 -1.1 194006.6IPI:IPI00 2 6 11.20% 277 29891 8 U Tax_Id=10090 Gene_Symbol=Psmb7 Proteasome subunit beta type-7 * FOXO_KO_w 4.3497 0.2577 99.9 1509.707 1508.705 -0.8 72327.1* FOXO_KO.4 4.886 0.3594 100 2136.055 2134.047 0.5 77949IPI:IPI00 1 1 11.20% 188 20123 5.6 U Tax_Id=10090 Gene_Symbol=Fdx1 Adrenodoxin, mitochondrial IPI:IPI00 1 1 12.70% 166 17712 5.1 U Tax_Id=10090 Gene_Symbol=Fdx1 Putative uncharacterized protein

FOXO_KO.4 6.8698 0.5555 100 2369.106 2367.102 -1.4 71873IPI:IPI00 1 1 11.20% 169 19285 7.9 U Tax_Id=10090 Gene_Symbol=Pop5 Ribonuclease P/MRP protein subunit POP5 * FOXO_KO.5 2.7861 0.271 99.6 2348.195 2347.201 -4.1 32094IPI:IPI00 1 1 11.20% 160 18637 10.4 U Tax_Id=10090 Gene_Symbol=Gm16376 hypothetical protein IPI:IPI00 1 1 11.20% 160 18495 10.4 U Tax_Id=10090 Gene_Symbol=- 18 kDa protein IPI:IPI00 1 1 11.20% 160 18627 10.4 U Tax_Id=10090 Gene_Symbol=Gm9104 ribosomal protein L21-like IPI:IPI00 1 1 12.20% 147 17227 10.3 U Tax_Id=10090 Gene_Symbol=Gm16060 similar to ribosomal protein L21 IPI:IPI00 1 1 11.20% 160 18532 10.5 U Tax_Id=10090 Gene_Symbol=LOC100048241;Gm10155 hypothetical protein IPI:IPI005 1 1 11.20% 160 18562 10.5 U Tax_Id=10090 Gene_Symbol=Rpl21 60S ribosomal protein L21 IPI:IPI00 1 1 11.20% 160 18609 10.4 U Tax_Id=10090 Gene_Symbol=Gm7218 hypothetical protein

IPI:IPI004 1 1 11.20% 160 18606 10.5 U Tax_Id=10090 Gene_Symbol=LOC100047314;Gm11703 hypothetical protein IPI:IPI00 1 1 11.10% 162 18815 10.4 U Tax_Id=10090 Gene_Symbol=Gm16415 hypothetical protein isoform 1 IPI:IPI00 1 1 11.60% 155 18027 10.4 U Tax_Id=10090 Gene_Symbol=Gm5495 hypothetical protein isoform 1 IPI:IPI004 1 1 11.20% 160 18655 10.3 U Tax_Id=10090 Gene_Symbol=Gm5445 similar to hCG1782414 isoform 1 IPI:IPI00 1 1 11.20% 160 18589 10.3 U Tax_Id=10090 Gene_Symbol=- 19 kDa protein IPI:IPI00 1 1 11.20% 160 18579 10.5 U Tax_Id=10090 Gene_Symbol=Gm10240;Rpl21;Gm15150;Gm10163;LOC100046290;Gm14648;LOC100044606 ribosomal protein L21 IPI:IPI00 1 1 12.30% 146 16916 10.6 U Tax_Id=10090 Gene_Symbol=Gm5201 hypothetical protein

FOXO_KO.3 4.3388 0.2179 99.9 2079.021 2078.015 1.2 211628.3IPI:IPI00 1 2 11.20% 134 15826 10.5 U Tax_Id=10090 Gene_Symbol=Mrpl55 Isoform 2 of 39S ribosomal protein L55, mitochondrial IPI:IPI00 1 2 11.80% 127 15122 10.5 U Tax_Id=10090 Gene_Symbol=Mrpl55 Isoform 1 of 39S ribosomal protein L55, mitochondrial

FOXO_KO.1 5.5888 0.4631 100 1837.827 1836.825 -0.5 103560.6IPI:IPI00 1 1 11.10% 207 23490 6.7 U Tax_Id=10090 Gene_Symbol=Rab7 Ras-related protein Rab-7a * FOXO_KO.2 5.616 0.485 100 2748.419 2747.414 0.7 94605.3IPI:IPI00 2 2 11.10% 117 13301 7 U Tax_Id=10090 Gene_Symbol=Lmna 13 kDa protein

FOXO_KO.1 5.1827 0.337 100 1630.811 1629.808 -0.1 172523.8FOXO_KO.1 3.0993 0.3274 99.9 1629.807 1629.808 -0.4 202908

IPI:IPI001 2 2 11.00% 391 45162 8 U Tax_Id=10090 Gene_Symbol=Csnk2a1 Casein kinase II subunit alpha IPI:IPI00 2 2 11.00% 391 45134 7.7 U Tax_Id=10090 Gene_Symbol=Csnk2a1;Gm10031 casein kinase 2, alpha 1 polypeptide

FOXO_KO.2 4.7482 0.3552 99.9 2831.24 2830.238 -0.7 69788.7FOXO_KO.3 3.2843 0.3742 100 2544.246 2544.25 -1.6 30304

IPI:IPI00 1 3 11.00% 228 25839 9 U Tax_Id=10090 Gene_Symbol=Mettl1 26 kDa protein IPI:IPI00 1 3 25.80% 97 10862 5.8 U Tax_Id=10090 Gene_Symbol=Mettl1 Protein

FOXO_KO.4 4.4686 0.3184 99.9 3072.492 3070.491 -1.6 88587.2IPI:IPI00 2 2 11.00% 154 16832 5.2 U Tax_Id=10090 Gene_Symbol=Eif5a Eukaryotic translation initiation factor 5A-1 IPI:IPI00 2 2 4.80% 357 39983 4.9 U Tax_Id=10090 Gene_Symbol=Eif5al3 similar to initiation factor 4D IPI:IPI00 2 2 5.70% 299 34717 4.9 U Tax_Id=10090 Gene_Symbol=Eif5al3 similar to initiation factor 4D IPI:IPI00 2 2 11.40% 149 16303 5 U Tax_Id=10090 Gene_Symbol=Eif5a 16 kDa protein

FOXO_KO.1 3.4237 0.3332 100 1341.699 1341.701 -1.3 168256.4FOXO_KO.1 5.5363 0.3413 100 1970.028 1969.024 0.3 145050.3

IPI:IPI00 1 1 11.00% 145 16052 10 U Tax_Id=10090 Gene_Symbol=Mtdh Putative uncharacterized protein FOXO_KO.2 5.9659 0.5049 100 1804.808 1804.81 -1.1 129145.9

IPI:IPI00 1 1 11.00% 118 12861 5.5 U Tax_Id=10090 Gene_Symbol=Mtpn Myotrophin * FOXO_KO.1 3.8907 0.4403 100 1465.715 1465.717 -1.2 269176.1IPI:IPI00 1 4 11.00% 109 12558 6.5 U Tax_Id=10090 Gene_Symbol=Acta2 Putative uncharacterized protein

FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6IPI:IPI00 1 1 11.00% 91 9474 10.5 U Tax_Id=10090 Gene_Symbol=H2afv Histone H2A IPI:IPI00 1 1 11.10% 90 9375 10.5 U Tax_Id=10090 Gene_Symbol=H2afv Histone H2A IPI:IPI00 1 1 11.10% 90 9417 9.6 U Tax_Id=10090 Gene_Symbol=H2afz Histone H2A IPI:IPI00 1 1 9.50% 105 10984 10.5 U Tax_Id=10090 Gene_Symbol=Gm8203;H2afz Histone H2A

FOXO_KO.1 2.4789 0.3595 99.9 1118.558 1118.558 0.2 228206.7IPI:IPI00 8 10 10.90% 1657 188755 6.5 U Tax_Id=10090 Gene_Symbol=Iqgap1 Ras GTPase-activating-like protein IQGAP1 * FOXO_KO.3 4.9185 0.4512 100 2446.126 2446.127 -0.4 92525.3* FOXO_KO.5 5.6229 0.5362 100 2960.599 2958.589 0.9 41034.8* FOXO_KO.3 4.3592 0.3709 100 2064.033 2063.029 0.3 88090.4* FOXO_KO.3 5.4016 0.3019 99.9 3674.741 3673.736 0.3 34671.5* FOXO_KO.3 5.1406 0.502 100 2579.251 2578.249 -0.5 130510.6* FOXO_KO.1 3.3007 0.3925 99.9 1943.938 1942.939 -2.4 316367.2* FOXO_KO.3 3.8 0.2489 99.9 2870.37 2868.365 -0.5 15097.9

* FOXO_KO.3 4.7625 0.4968 100 2022.009 2022.007 1.4 149763.1IPI:IPI007 5 9 10.90% 561 57041 5.1 U Tax_Id=10090 Gene_Symbol=Krt10 keratin complex 1, acidic, gene 10 IPI:IPI008 5 9 10.90% 561 57060 5.1 U Tax_Id=10090 Gene_Symbol=Krt10 Isoform 2 of Keratin, type I cytoskeletal 10

FOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9FOXO_KO.1 4.4947 0.4664 100 1381.648 1381.648 0.2 1963621FOXO_KO.3 5.6327 0.5315 100 2874.398 2872.393 -0.6 22109.1FOXO_KO.3 4.7046 0.3619 99.9 2873.401 2872.393 1.6 70284.9FOXO_KO.1 3.4083 0.4884 100 1390.68 1390.681 -0.7 150393.8

IPI:IPI00 2 2 10.90% 375 39771 8.1 U Tax_Id=10090 Gene_Symbol=Adh1 Alcohol dehydrogenase 1 * FOXO_KO.3 3.3408 0.3211 99.9 4084.077 4083.07 0.9 7101.5* FOXO_KO.3 5.8469 0.5034 100 4085.076 4083.07 -0.3 1103210IPI:IPI00 6 6 10.80% 910 102088 7.4 U Tax_Id=10090 Gene_Symbol=Snd1 Staphylococcal nuclease domain-containing protein 1 * FOXO_KO.3 4.5305 0.4572 100 1959.962 1959.962 0.1 96743.8* FOXO_KO.3 4.8559 0.4575 100 2307.155 2306.155 -1.7 95360.1* FOXO_KO.1 2.9595 0.2326 99.8 1293.588 1293.588 0.2 222361.4* FOXO_KO.4 5.4904 0.4139 100 3561.753 3559.748 -0.4 62993.3* FOXO_KO.1 4.0618 0.4628 100 1883.783 1883.783 0.1 83887.1* FOXO_KO.1 3.0433 0.3122 99.9 1883.78 1883.783 -1.7 250227IPI:IPI00 5 6 10.80% 740 82500 7.2 U Tax_Id=10090 Gene_Symbol=Ddx1 ATP-dependent RNA helicase DDX1 * FOXO_KO.3 5.2827 0.4182 100 1956.012 1954.024 -9.6 131461.1* FOXO_KO.4 5.339 0.6263 100 2372.176 2372.177 -0.4 53784.5* FOXO_KO.4 4.4795 0.4338 100 2373.183 2372.177 1.4 148848.1* FOXO_KO.1 5.2618 0.3333 100 2002.927 2002.929 -0.8 92398.5* FOXO_KO.2 4.6041 0.3578 99.9 2573.169 2572.181 -5.7 86353.1IPI:IPI002 2 2 10.80% 538 60787 9.1 U Tax_Id=10090 Gene_Symbol=Gnl3 Isoform 1 of Guanine nucleotide-binding protein-like 3

FOXO_KO.9 3.6924 0.2186 99.5 2602.206 2602.211 -2 147894.8* FOXO_KO.1 3.72 0.2957 99.9 3722.698 3722.703 -1.4 27259.4IPI:IPI001 3 3 10.80% 482 54088 5.6 U Tax_Id=10090 Gene_Symbol=G3bp2 Isoform A of Ras GTPase-activating protein-binding protein 2


IPI:IPI00 4 4 10.80% 462 50546 9.5 U Tax_Id=10090 Gene_Symbol=Lsm14a Protein LSM14 homolog A * FOXO_KO.4 2.857 0.336 99.9 1711.908 1710.905 -0.3 9211.8

FOXO_KO.2 4.7137 0.3514 100 2174.962 2174.962 -0.2 98895.5FOXO_KO.2 4.8516 0.437 100 2831.269 2830.27 -1.7 79479.5

* FOXO_KO.1 3.0543 0.4742 100 1489.597 1489.601 -2.9 224923.7IPI:IPI004 2 2 10.80% 407 46402 5.5 U Tax_Id=10090 Gene_Symbol=Eif4a2 Isoform 1 of Eukaryotic initiation factor 4A-II IPI:IPI00 2 2 12.20% 362 41290 5.6 U Tax_Id=10090 Gene_Symbol=Eif4a2 eukaryotic translation initiation factor 4A2 isoform c IPI:IPI004 2 2 10.80% 408 46489 5.5 U Tax_Id=10090 Gene_Symbol=Eif4a2 Isoform 2 of Eukaryotic initiation factor 4A-II

FOXO_KO.4 5.363 0.5407 100 3475.493 3473.49 -0.8 56742.1FOXO_KO.3 5.1986 0.4433 100 1556.713 1555.713 -2.4 332300.8

IPI:IPI00 4 4 10.80% 389 44173 7.5 U Tax_Id=10090 Gene_Symbol=Psmc6 26S protease regulatory subunit S10B * FOXO_KO.3 5.2222 0.5584 100 2087.97 2086.969 -0.9 125047* FOXO_KO.3 4.2897 0.307 99.9 2087.971 2086.969 -0.7 107147.9* FOXO_KO.1 4.2121 0.3887 100 1273.641 1273.642 -1.1 244675.8* FOXO_KO.1 4.4058 0.4437 100 1580.702 1580.705 -1.9 190213.7IPI:IPI00 2 2 10.80% 268 30016 5.2 U Tax_Id=10090 Gene_Symbol=Mapre1 Microtubule-associated protein RP/EB family member 1 * FOXO_KO.1 3.0736 0.2841 99.9 1231.652 1231.653 -0.4 260624.2

* FOXO_KO.2 5.0383 0.4039 100 2270.067 2270.072 -2.3 89410.8IPI:IPI00 1 1 10.80% 166 19415 10.1 U Tax_Id=10090 Gene_Symbol=Rps11 Putative uncharacterized protein IPI:IPI00 1 1 11.40% 158 18431 10.3 U Tax_Id=10090 Gene_Symbol=Rps11 40S ribosomal protein S11 IPI:IPI00 1 1 11.40% 158 18286 9.9 U Tax_Id=10090 Gene_Symbol=Gm9808 hypothetical protein

FOXO_KO.2 5.768 0.4885 100 1986.031 1986.033 -0.8 383136.9IPI:IPI00 6 10 10.70% 590 65003 9.5 U Tax_Id=10090 Gene_Symbol=Pabpc4 Putative uncharacterized protein

FOXO_KO.1 5.4766 0.3856 100 1713.793 1712.792 -1 101707.2FOXO_KO.1 4.8403 0.4726 100 2155.051 2154.05 -1.3 176626.6FOXO_KO.3 7.0531 0.6044 100 2274.073 2273.072 -0.9 89316FOXO_KO.3 3.3875 0.3812 99.9 2273.074 2273.072 1 136513.5FOXO_KO.4 6.0407 0.5297 100 2741.394 2740.389 0.6 25547.1FOXO_KO.4 3.6745 0.4621 100 2741.396 2740.389 1.3 45001.9

IPI:IPI007 5 9 10.70% 570 57770 5.1 U Tax_Id=10090 Gene_Symbol=Krt10 Isoform 1 of Keratin, type I cytoskeletal 10 FOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9FOXO_KO.1 4.4947 0.4664 100 1381.648 1381.648 0.2 1963621FOXO_KO.3 5.6327 0.5315 100 2874.398 2872.393 -0.6 22109.1FOXO_KO.3 4.7046 0.3619 99.9 2873.401 2872.393 1.6 70284.9FOXO_KO.1 3.4083 0.4884 100 1390.68 1390.681 -0.7 150393.8

IPI:IPI00 2 2 10.70% 391 45345 4.5 U Tax_Id=10090 Gene_Symbol=Nap1l1 Nucleosome assembly protein 1-like 1 IPI:IPI00 2 2 10.00% 418 48543 4.5 U Tax_Id=10090 Gene_Symbol=Nap1l1 nucleosome assembly protein 1-like 1 isoform 1

FOXO_KO.1 2.9587 0.2441 99.8 1336.616 1336.617 -0.6 349745.7FOXO_KO.3 3.9124 0.3697 99.9 3957.779 3956.779 -1 29375.9

IPI:IPI00 2 3 10.70% 382 42433 5.4 U Tax_Id=10090 Gene_Symbol=Ppm1a Protein phosphatase 1A * FOXO_KO.1 6.023 0.4418 100 2031.995 2031.998 -1.7 116985.9* FOXO_KO.3 4.6924 0.3656 99.9 2786.342 2785.338 0.1 143020.3IPI:IPI00 2 2 10.70% 356 38773 8.9 U Tax_Id=10090 Gene_Symbol=Lactb Putative uncharacterized protein

FOXO_KO.2 5.3243 0.4873 100 1724.796 1723.792 0.4 242794.7FOXO_KO.2 4.7506 0.3994 100 2775.358 2774.356 -0.4 130246.7

IPI:IPI00 2 2 10.70% 307 34877 9.5 U Tax_Id=10090 Gene_Symbol=Lrrc59 Leucine-rich repeat-containing protein 59 IPI:IPI00 2 2 17.70% 186 20409 6.7 U Tax_Id=10090 Gene_Symbol=Lrrc59 Putative uncharacterized protein

FOXO_KO.3 4.6585 0.2098 99.7 3533.892 3532.886 0.8 112956.8FOXO_KO.2 7.5661 0.4493 100 2314.184 2313.182 -0.6 131352.2

IPI:IPI003 3 3 10.70% 270 30945 11.4 U Tax_Id=10090 Gene_Symbol=Sfrs5 Splicing factor, arginine/serine-rich 5 IPI:IPI00 3 3 10.80% 268 30833 11.5 U Tax_Id=10090 Gene_Symbol=Sfrs5 31 kDa protein IPI:IPI00 3 3 10.80% 269 30891 11.6 U Tax_Id=10090 Gene_Symbol=Sfrs5 splicing factor, arginine/serine-rich 5 IPI:IPI00 3 3 10.70% 270 30978 11.6 U Tax_Id=10090 Gene_Symbol=Sfrs5 MCG7614, isoform CRA_c IPI:IPI006 3 3 10.80% 269 30748 11.6 U Tax_Id=10090 Gene_Symbol=Gm12966 similar to SRp40-1

FOXO_KO.3 4.6048 0.4721 100 2592.155 2591.157 -2.1 80230.7FOXO_KO.3 3.9093 0.2577 99.7 2592.155 2591.157 -2 216605.4FOXO_KO.3 4.4261 0.3401 99.9 3366.492 3365.49 -0.6 88146.3

IPI:IPI00 1 1 10.70% 149 16701 4.3 U Tax_Id=10090 Gene_Symbol=Calml3 Calmodulin-like protein 3 IPI:IPI002 1 1 5.40% 295 33168 5.2 U Tax_Id=10090 Gene_Symbol=Gm7308 similar to calmodulin

FOXO_KO.1 3.8534 0.195 99.5 1984.945 1983.944 -1 130037.3IPI:IPI001 6 6 10.60% 679 73528 6.2 U Tax_Id=10090 Gene_Symbol=Hspa9 Stress-70 protein, mitochondrial IPI:IPI00 6 6 10.60% 679 73461 6.1 U Tax_Id=10090 Gene_Symbol=Hspa9 heat shock protein 9

FOXO_KO.2 3.4163 0.2527 99.9 1242.68 1242.68 0.1 287564.3FOXO_KO.3 5.4239 0.5099 100 2056.967 2055.962 1 197463.3FOXO_KO.2 6.7411 0.5095 100 2419.218 2418.218 -1.6 83979.8

FOXO_KO.2 6.7591 0.5986 100 2142.046 2142.05 -1.7 217662FOXO_KO.2 5.9384 0.2752 99.9 2143.053 2142.05 -0.1 516417.5FOXO_KO.2 3.2367 0.3855 99.9 1856.903 1856.906 -1.3 148979.1

IPI:IPI00 5 24 10.60% 491 56058 7.4 U Tax_Id=10090 Gene_Symbol=Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 * FOXO_KO.2 4.7104 0.52 100 1520.675 1519.67 1.1 330668.6

FOXO_KO.2 3.2254 0.3837 100 1135.638 1135.636 1.7 236375.4FOXO_KO.3 5.1299 0.2829 100 1666.839 1666.84 -0.1 24365.1FOXO_KO.3 3.9353 0.235 99.9 1667.842 1666.84 -0.5 53614.2FOXO_KO.1 2.5524 0.2931 99.5 1826.838 1826.843 -2.3 246023.8

IPI:IPI00 2 2 10.60% 377 42509 9.7 U Tax_Id=10090 Gene_Symbol=Ndufa9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial IPI:IPI00 2 2 10.60% 377 42525 9.7 U Tax_Id=10090 Gene_Symbol=Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 precursor

FOXO_KO.3 4.8573 0.4991 100 1611.782 1611.78 1 181837.3FOXO_KO.3 4.861 0.3157 99.9 2928.546 2927.544 -0.4 90069.3

IPI:IPI00 2 2 10.60% 359 38937 6.9 U Tax_Id=10090 Gene_Symbol=Pdhb Pyruvate dehydrogenase E1 component subunit beta, mitochondrial * FOXO_KO.5 4.4066 0.439 100 3010.447 3008.438 0.7 29090.3* FOXO_KO.2 3.6186 0.3188 100 1332.663 1331.662 -2.2 321997.5IPI:IPI00 1 1 10.60% 284 33363 9.4 U Tax_Id=10090 Gene_Symbol=Nipsnap1 Protein NipSnap homolog 1 IPI:IPI00 1 1 22.10% 136 15883 7.4 U Tax_Id=10090 Gene_Symbol=Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 IPI:IPI00 1 1 9.40% 319 37523 8.7 U Tax_Id=10090 Gene_Symbol=Nipsnap1 Putative uncharacterized protein

FOXO_KO.3 4.2306 0.2334 99.7 3702.689 3701.687 -0.4 30477.1IPI:IPI00 1 2 10.60% 142 15202 8.8 U Tax_Id=10090 Gene_Symbol=Hba-a1;Hba-a2 Putative uncharacterized protein IPI:IPI00 1 2 10.60% 142 15112 8.2 U Tax_Id=10090 Gene_Symbol=Hba-a1;Hba-a2 hemoglobin alpha, adult chain 2 IPI:IPI00 1 2 10.60% 142 15085 8.2 U Tax_Id=10090 Gene_Symbol=Hba-a1;Hba-a2 Hemoglobin subunit alpha

FOXO_KO.1 3.8364 0.361 100 1530.739 1529.734 0.7 250252.6IPI:IPI00 1 1 10.60% 123 14553 11.1 U Tax_Id=10090 Gene_Symbol=Gm2000;Rpl35 60S ribosomal protein L35 IPI:IPI00 1 1 10.60% 123 14586 11.1 U Tax_Id=10090 Gene_Symbol=Gm10269 similar to ribosomal protein L35

FOXO_KO.2 2.8684 0.2689 99.6 1556.862 1556.864 -1.3 541919.9IPI:IPI00 6 7 10.50% 622 70239 7.5 U Tax_Id=10090 Gene_Symbol=Acsm3 Isoform 2 of Acyl-coenzyme A synthetase ACSM3, mitochondrial IPI:IPI00 6 7 11.20% 580 65623 7.5 U Tax_Id=10090 Gene_Symbol=Acsm3 Isoform 1 of Acyl-coenzyme A synthetase ACSM3, mitochondrial

FOXO_KO.3 3.3449 0.2483 99.9 1371.705 1370.699 2.2 206536.4FOXO_KO.5 3.8323 0.3433 99.9 2731.323 2730.312 2.8 55601.9FOXO_KO.2 4.258 0.4306 100 1378.629 1378.631 -1.6 388582.2FOXO_KO.2 4.7836 0.3073 100 2139.974 2138.975 -1.7 182328.8FOXO_KO.3 5.641 0.4788 100 1756.752 1755.747 0.9 196417.2FOXO_KO.1 4.2034 0.3448 100 1225.604 1225.606 -1.7 304936.8

IPI:IPI004 2 4 10.50% 219 24969 9.6 U Tax_Id=10090 Gene_Symbol=Nono Isoform 2 of Non-POU domain-containing octamer-binding protein FOXO_KO.5 6.653 0.4629 100 2670.337 2668.325 1.9 40286.4FOXO_KO.5 5.9591 0.5291 100 2669.329 2668.325 0.2 738237.7

IPI:IPI00 1 2 10.50% 172 19992 8.5 U Tax_Id=10090 Gene_Symbol=Ndufa8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 * FOXO_KO.3 6.0305 0.5409 100 2024.141 2022.137 -1.3 94136.5IPI:IPI002 4 5 10.40% 589 66269 8.7 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO3 of Fragile X mental retardation protein 1 homolog IPI:IPI00 4 5 9.70% 631 70811 7.6 U Tax_Id=10090 Gene_Symbol=Fmr1 71 kDa protein IPI:IPI00 4 5 10.30% 591 66532 7.1 U Tax_Id=10090 Gene_Symbol=Fmr1 67 kDa protein IPI:IPI004 4 5 10.30% 593 66717 7.2 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO8 of Fragile X mental retardation protein 1 homolog IPI:IPI004 4 5 9.90% 614 68989 7.6 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO1 of Fragile X mental retardation protein 1 homolog IPI:IPI004 4 5 10.30% 593 66817 7.4 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO7 of Fragile X mental retardation protein 1 homolog IPI:IPI002 4 5 9.90% 614 68890 7.4 U Tax_Id=10090 Gene_Symbol=Fmr1 Fragile X mental retardation syndrome 1 homolog IPI:IPI002 4 5 12.40% 491 55940 5.8 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO12 of Fragile X mental retardation protein 1 homolog

IPI:IPI002 4 5 10.40% 585 65919 8.5 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO11 of Fragile X mental retardation protein 1 homolog IPI:IPI002 4 5 14.30% 427 48656 6.4 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO10 of Fragile X mental retardation protein 1 homolog IPI:IPI002 4 5 10.40% 589 66170 8.5 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO9 of Fragile X mental retardation protein 1 homolog IPI:IPI002 4 5 11.90% 512 58113 5.9 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO6 of Fragile X mental retardation protein 1 homolog IPI:IPI002 4 5 14.00% 436 49353 6.4 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO5 of Fragile X mental retardation protein 1 homolog IPI:IPI002 4 5 13.60% 448 50829 6.5 U Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO4 of Fragile X mental retardation protein 1 homolog

FOXO_KO.2 5.7109 0.5295 100 2287.043 2286.042 -1.1 64236.5FOXO_KO.1 4.9082 0.4305 100 1556.696 1554.692 -1.7 187866.9FOXO_KO.2 4.8771 0.4719 100 3137.48 3136.478 -0.5 78339.6FOXO_KO.2 4.0919 0.3097 99.9 3265.572 3264.573 -1.3 64205

IPI:IPI00 3 3 10.40% 530 60929 8.3 U Tax_Id=10090 Gene_Symbol=Ugt2b38 UDP glucuronosyltransferase 2 family, polypeptide B38 FOXO_KO.6 3.9874 0.4014 100 3161.447 3159.436 1.5 14389.4FOXO_KO.6 4.7173 0.4957 100 3160.443 3159.436 1.2 60140.9FOXO_KO.6 3.8318 0.3727 99.9 3279.744 3278.738 0.9 48777.8

IPI:IPI00 2 2 10.40% 517 59267 7.5 U Tax_Id=10090 Gene_Symbol=Pdia5 Protein disulfide-isomerase A5 * FOXO_KO.4 6.4659 0.4952 100 2423.171 2421.165 0 97668.8* FOXO_KO.3 3.9275 0.2858 99.9 3854.811 3852.803 0.3 17508IPI:IPI00 4 7 10.40% 336 36377 8.7 U Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 2 of Heterogeneous nuclear ribonucleoprotein D0 IPI:IPI003 4 7 12.20% 287 30778 8.9 U Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 4 of Heterogeneous nuclear ribonucleoprotein D0

FOXO_KO.1 4.0413 0.3188 100 1488.756 1488.758 -1.6 271153.4FOXO_KO.3 5.2964 0.343 100 2431.168 2430.165 0 68423.9FOXO_KO.3 4.1674 0.2917 99.9 2431.168 2430.165 -0.1 391428.4FOXO_KO.3 5.7203 0.4828 100 2162.978 2160.98 -3.8 123987

IPI:IPI00 1 1 10.40% 298 33752 6.4 U Tax_Id=10090 Gene_Symbol=Golph3 Isoform 1 of Golgi phosphoprotein 3 * FOXO_KO.5 4.1803 0.3273 99.9 3432.827 3430.815 1.7 33514.1IPI:IPI00 8 10 10.30% 692 76664 5.1 U Tax_Id=10090 Gene_Symbol=Caprin1 cytoplasmic activation/proliferation-associated protein 1 isoform c IPI:IPI00 8 10 10.20% 698 77089 5.4 U Tax_Id=10090 Gene_Symbol=Caprin1 cytoplasmic activation/proliferation-associated protein 1 isoform b IPI:IPI00 8 10 10.00% 707 78169 5.2 U Tax_Id=10090 Gene_Symbol=Caprin1 Caprin-1

FOXO_KO.3 6.5339 0.5884 100 2092.1 2091.097 -0.2 140490.4FOXO_KO.3 4.047 0.4285 100 2092.1 2091.097 -0.2 134392.3FOXO_KO.3 4.8316 0.4196 100 2549.355 2548.35 0.6 208964.4FOXO_KO.4 5.9146 0.5047 100 2467.273 2466.265 1.8 75949.1FOXO_KO.4 3.9542 0.2599 99.8 2467.272 2466.265 1.5 156984.8FOXO_KO.3 6.1369 0.4897 100 2296.143 2295.14 -0.3 51945FOXO_KO.3 4.46 0.3929 100 2296.143 2295.14 -0.3 157363.6FOXO_KO_w 2.9457 0.2176 99.8 999.4523 999.453 -0.7 27421.6

IPI:IPI00 2 2 10.30% 474 53121 7.1 U Tax_Id=10090 Gene_Symbol=Coro1c Coronin-1C * FOXO_KO.3 3.493 0.3538 99.9 2441.134 2440.134 -1.6 160809.9* FOXO_KO.3 5.4135 0.4941 100 3272.502 3271.495 1 66547.5IPI:IPI001 1 1 10.30% 281 31293 5 U Tax_Id=10090 Gene_Symbol=Eef1d Isoform 1 of Elongation factor 1-delta IPI:IPI009 1 1 4.40% 660 72931 6.4 U Tax_Id=10090 Gene_Symbol=Eef1d Isoform 3 of Elongation factor 1-delta IPI:IPI00 1 1 11.80% 245 27218 5.5 U Tax_Id=10090 Gene_Symbol=Eef1d 27 kDa protein IPI:IPI00 1 1 14.90% 194 21549 5.5 U Tax_Id=10090 Gene_Symbol=Eef1d 22 kDa protein IPI:IPI00 1 1 13.80% 210 23172 5.6 U Tax_Id=10090 Gene_Symbol=Eef1d 23 kDa protein IPI:IPI006 1 1 11.30% 257 28729 4.9 U Tax_Id=10090 Gene_Symbol=Eef1d Isoform 2 of Elongation factor 1-delta

FOXO_KO.1 4.6007 0.435 100 3277.322 3276.322 -1.2 42789.3IPI:IPI00 2 2 10.30% 232 25606 7.4 U Tax_Id=10090 Gene_Symbol=Ak2 Isoform 2 of Adenylate kinase 2, mitochondrial IPI:IPI00 2 2 10.00% 239 26469 7.4 U Tax_Id=10090 Gene_Symbol=Ak2 Isoform 1 of Adenylate kinase 2, mitochondrial

FOXO_KO.3 4.119 0.45 100 1503.795 1503.798 -1.4 451099.2FOXO_KO.2 2.4305 0.3526 99.8 1322.596 1322.597 -0.5 132760.2

IPI:IPI001 2 3 10.30% 145 16248 10.3 U Tax_Id=10090 Gene_Symbol=Gm14072 hypothetical protein isoform 3 FOXO_KO.2 4.709 0.3533 100 1969.925 1968.924 -1.2 317747.5FOXO_KO.2 4.2331 0.472 100 1704.773 1703.77 0 127715.5

IPI:IPI00 4 6 10.20% 806 90885 5.8 U Tax_Id=10090 Gene_Symbol=Sart1 U4/U6.U5 tri-snRNP-associated protein 1 * FOXO_KO.3 5.4906 0.4887 100 2102.968 2102.967 0.5 154986.2* FOXO_KO.2 7.0907 0.5448 100 2473.241 2472.24 -1 191187.4* FOXO_KO.1 5.4234 0.5071 100 2706.342 2705.342 -1 129381* FOXO_KO.2 2.918 0.3622 99.9 2019.922 2019.925 -1.5 249604.5IPI:IPI00 3 4 10.20% 647 72567 8.3 U Tax_Id=10090 Gene_Symbol=Acox1 Putative uncharacterized protein

FOXO_KO.3 3.8145 0.287 99.9 3236.617 3236.616 0.4 221722.1FOXO_KO.3 4.6914 0.4279 100 2506.323 2505.32 -0.1 157103.7FOXO_KO.3 4.5158 0.487 100 1747.8 1747.796 2 145366.3

IPI:IPI00 3 4 10.20% 501 57117 6.5 U Tax_Id=10090 Gene_Symbol=Dars Aspartyl-tRNA synthetase, cytoplasmic IPI:IPI00 3 4 10.20% 501 57147 6.5 U Tax_Id=10090 Gene_Symbol=Dars aspartyl-tRNA synthetase isoform 1


contamina 5 6 10.20% 471 51531 5.2 U no descriptionFOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9FOXO_KO.1 4.3926 0.3543 100 1301.656 1301.658 -2 249696.4FOXO_KO.3 6.369 0.4548 100 2124.096 2123.094 -0.8 108053.7FOXO_KO.3 3.1997 0.3447 99.9 2123.091 2123.094 -1.3 109595.6FOXO_KO.2 2.8754 0.402 100 1172.524 1172.526 -1.7 175608.3

IPI:IPI00 1 1 10.20% 118 13077 6.5 U Tax_Id=10090 Gene_Symbol=Ddt D-dopachrome decarboxylase * FOXO_KO.2 3.3867 0.3588 100 1465.714 1465.717 -1.9 159781.3IPI:IPI00 2 2 10.10% 435 49655 9.5 U Tax_Id=10090 Gene_Symbol=Ap2m1 AP-2 complex subunit mu IPI:IPI00 2 2 10.20% 433 49389 9.5 U Tax_Id=10090 Gene_Symbol=Ap2m1 Adaptor protein complex AP-2, mu1, isoform CRA_a

FOXO_KO.6 4.6161 0.4174 100 3216.617 3215.615 -0.4 53049.7FOXO_KO.2 3.8017 0.2921 99.9 1786.904 1786.907 -1.6 134420

IPI:IPI00 3 7 10.10% 377 42051 5.4 U Tax_Id=10090 Gene_Symbol=Acta1 Actin, alpha skeletal muscle IPI:IPI00 3 7 14.10% 270 30065 5 U Tax_Id=10090 Gene_Symbol=Actg2 30 kDa protein IPI:IPI006 3 7 10.10% 377 42118 5.5 U Tax_Id=10090 Gene_Symbol=Actc1 Putative uncharacterized protein IPI:IPI00 3 7 10.10% 377 42047 5.4 U Tax_Id=10090 Gene_Symbol=Actc1 Putative uncharacterized protein IPI:IPI00 3 7 10.10% 377 41947 5.5 U Tax_Id=10090 Gene_Symbol=Actc1 Putative uncharacterized protein IPI:IPI00 3 7 10.10% 376 41877 5.5 U Tax_Id=10090 Gene_Symbol=Actg2 Actin, gamma-enteric smooth muscle IPI:IPI00 3 7 9.70% 393 42880 5.6 U Tax_Id=10090 Gene_Symbol=Actg2 Smooth muscle gamma-actin IPI:IPI00 3 7 10.10% 377 42009 5.4 U Tax_Id=10090 Gene_Symbol=Acta2 Actin, aortic smooth muscle IPI:IPI00 3 7 10.10% 377 42019 5.4 U Tax_Id=10090 Gene_Symbol=Actc1 Actin, alpha cardiac muscle 1

FOXO_KO_w 2.9233 0.3351 99.9 976.4484 976.4483 0.1 38651.7FOXO_KO.3 3.2722 0.3866 100 1354.622 1354.623 -1.3 47103.6FOXO_KO.2 3.905 0.3989 100 1790.888 1790.892 -2.3 118028.2

IPI:IPI00 1 1 10.10% 158 18733 5.7 U Tax_Id=10090 Gene_Symbol=Ap1s1 AP-1 complex subunit sigma-1A * FOXO_KO.1 6.0992 0.4471 100 1843.873 1842.872 -1.2 53239.4IPI:IPI00 1 1 10.00% 140 14957 8.3 U Tax_Id=10090 Gene_Symbol=Pfn1 Profilin-1 IPI:IPI00 1 1 12.50% 112 11820 4.9 U Tax_Id=10090 Gene_Symbol=Pfn1 Profilin

FOXO_KO.3 4.8775 0.4278 100 1640.767 1639.763 0 249925.6

IPI:IPI00 1 1 9.90% 313 34218 8.1 U Tax_Id=10090 Gene_Symbol=Gm9093 similar to Acidic ribosomal phosphoprotein P0 FOXO_KO.4 6.4739 0.4647 100 3504.777 3503.781 -1.9 39109

IPI:IPI00 1 1 9.90% 192 21881 10 U Tax_Id=10090 Gene_Symbol=Rpl9;Gm10321 60S ribosomal protein L9 IPI:IPI00 1 1 23.80% 80 9280 10.7 U Tax_Id=10090 Gene_Symbol=Rpl9 9 kDa protein IPI:IPI00 1 1 11.40% 166 19091 10.1 U Tax_Id=10090 Gene_Symbol=Rpl9 19 kDa protein IPI:IPI008 1 1 10.40% 182 20851 9.9 U Tax_Id=10090 Gene_Symbol=Gm10117 similar to 60S ribosomal protein L9 isoform 2 IPI:IPI004 1 1 9.90% 192 21853 9.9 U Tax_Id=10090 Gene_Symbol=Gm10117 similar to 60S ribosomal protein L9 isoform 1 IPI:IPI00 1 1 9.90% 192 21934 9.9 U Tax_Id=10090 Gene_Symbol=Gm5451 similar to 60S ribosomal protein L9

FOXO_KO.2 4.1706 0.4038 100 2127.151 2127.154 -1.6 94339.9IPI:IPI00 1 2 9.90% 182 21067 5.9 U Tax_Id=10090 Gene_Symbol=Fth1 Ferritin heavy chain * FOXO_KO.3 4.6809 0.4645 100 2119.951 2117.927 8.6 100441.4IPI:IPI00 1 1 9.90% 162 17760 5.4 U Tax_Id=10090 Gene_Symbol=Sep15 15 kDa selenoprotein * FOXO_KO.3 4.4725 0.386 100 1981.955 1981.95 2.2 76292.9IPI:IPI004 3 4 9.90% 151 16930 4.7 U Tax_Id=10090 Gene_Symbol=Myl6 Isoform Non-muscle of Myosin light polypeptide 6 IPI:IPI00 3 4 12.90% 116 12984 4.6 U Tax_Id=10090 Gene_Symbol=Gm8894 similar to non-muscle myosin alkali light chain IPI:IPI00 3 4 7.10% 210 23158 4.7 U Tax_Id=10090 Gene_Symbol=Gm8894 similar to non-muscle myosin alkali light chain IPI:IPI004 3 4 8.30% 180 20479 5.2 U Tax_Id=10090 Gene_Symbol=Gm5915 similar to 17,000 dalton myosin light chain IPI:IPI004 3 4 10.30% 146 16124 4.9 U Tax_Id=10090 Gene_Symbol=Gm5526 similar to MYL6 protein

FOXO_KO.1 5.8376 0.4254 100 1788.836 1786.824 2.9 298172.6FOXO_KO.1 4.2331 0.3625 99.9 1786.821 1786.824 -2 3115178FOXO_KO.2 4.0296 0.4129 100 1544.687 1544.686 0.3 299451.2

IPI:IPI00 6 9 9.80% 1107 123055 6.8 U Tax_Id=10090 Gene_Symbol=Otud4 Otud4 protein * FOXO_KO.3 6.402 0.5255 100 2051.952 2049.951 -2.8 114858.7* FOXO_KO.2 3.0518 0.3264 99.9 1477.676 1476.664 6.1 204676.1* FOXO_KO_w 3.813 0.3537 99.9 2233.113 2233.109 1.6 31574.3* FOXO_KO.3 4.1714 0.3199 99.9 2677.415 2675.414 -2 182311* FOXO_KO.1 4.8713 0.4999 100 1697.715 1696.712 -0.5 196781* FOXO_KO.1 3.1529 0.3579 99.9 2533.104 2532.101 -0.2 21830.3IPI:IPI00 4 5 9.80% 858 96407 5.5 U Tax_Id=10090 Gene_Symbol=Hsph1 Isoform HSP105-alpha of Heat shock protein 105 kDa IPI:IPI00 4 5 10.30% 817 91678 5.6 U Tax_Id=10090 Gene_Symbol=Hsph1 Putative uncharacterized protein

FOXO_KO.2 3.5232 0.5204 100 1479.707 1479.707 -0.6 232169.2FOXO_KO.2 3.6732 0.3739 99.9 2499.21 2497.203 0.1 245885.7FOXO_KO.1 6.1031 0.4661 100 3352.406 3351.411 -2.5 59710.9FOXO_KO.2 6.0142 0.5729 100 2168.988 2168.987 0.5 105636.9

IPI:IPI00 2 3 9.80% 245 26511 4.7 U Tax_Id=10090 Gene_Symbol=Eif6 Eukaryotic translation initiation factor 6 IPI:IPI00 2 3 9.80% 245 26580 4.8 U Tax_Id=10090 Gene_Symbol=Eif6 Eukaryotic translation initiation factor 6

FOXO_KO.3 6.04 0.423 100 2586.357 2584.346 1.4 49592.6FOXO_KO.3 4.3844 0.3871 99.9 2585.351 2584.346 0.6 84214.4

IPI:IPI00 1 1 9.80% 225 26032 5.8 U Tax_Id=10090 Gene_Symbol=Mobkl3 Mps one binder kinase activator-like 3 * FOXO_KO.4 4.5479 0.3968 100 2372.159 2371.151 1.8 31219.1IPI:IPI00 8 10 9.70% 1160 127353 6.6 U Tax_Id=10090 Gene_Symbol=Cps1 Carbamoyl-phosphate synthetase 1

FOXO_KO.2 5.4479 0.4853 100 1724.817 1723.817 -2.3 341398.8FOXO_KO.2 4.1805 0.4555 100 2808.412 2807.41 -0.5 29533FOXO_KO.3 5.0333 0.3921 100 2809.396 2807.41 -7.4 109982.7FOXO_KO.2 4.4864 0.5483 100 1607.795 1607.794 0.6 159201.4FOXO_KO.3 4.6787 0.4339 100 3167.595 3166.594 -0.6 118459.2FOXO_KO.3 5.8447 0.4131 100 1609.802 1607.799 -1.9 495120.2FOXO_KO.1 3.861 0.5246 100 1420.694 1420.691 1.5 190826.5

FOXO_KO.2 5.7871 0.4789 100 3737.738 3736.736 -0.3 37567.3IPI:IPI003 3 3 9.70% 834 88847 5.8 U Tax_Id=10090 Gene_Symbol=Trim28 Isoform 1 of Transcription intermediary factor 1-beta IPI:IPI004 3 3 16.20% 500 53826 7.5 U Tax_Id=10090 Gene_Symbol=Trim28 Isoform 2 of Transcription intermediary factor 1-beta

FOXO_KO.1 4.502 0.2334 99.8 3405.51 3404.511 -1.2 45842.7FOXO_KO.1 3.5105 0.3923 100 1520.709 1520.713 -2.5 179402.6FOXO_KO.2 5.0169 0.5563 100 3533.492 3532.49 -0.5 50869.8

IPI:IPI00 4 4 9.70% 505 55249 7.2 U Tax_Id=10090 Gene_Symbol=D10Wsu52e UPF0027 protein C22orf28 homolog FOXO_KO.2 3.4856 0.3486 100 1399.657 1398.654 -0.2 130925.4

* FOXO_KO.1 6.0908 0.5701 100 2129.866 2128.867 -1.9 97588.1* FOXO_KO.2 3.2921 0.2354 99.8 1206.599 1206.6 -1.1 214540.4* FOXO_KO.1 2.8672 0.3263 99.9 1295.619 1295.619 -0.2 317483.4IPI:IPI00 1 1 9.70% 340 38733 4.8 U Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 3 of Heterogeneous nuclear ribonucleoprotein U-like protein 1

FOXO_KO.3 3.909 0.2124 99.6 3946.692 3945.691 -0.5 172739.5IPI:IPI00 1 1 9.70% 185 20472 6.5 U Tax_Id=10090 Gene_Symbol=Dusp3 Dual specificity protein phosphatase 3 IPI:IPI00 1 1 8.60% 210 23223 7.3 U Tax_Id=10090 Gene_Symbol=Dusp3 Dual specificity phosphatase 3

FOXO_KO.3 5.0488 0.4052 100 2061.993 2059.987 -0.3 103645IPI:IPI00 3 3 9.70% 176 19596 6 U Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2

FOXO_KO.2 5.1619 0.3489 100 1812.869 1811.866 0.1 286947.7FOXO_KO.2 3.2203 0.386 99.9 1811.867 1811.866 0.8 156617.8FOXO_KO.2 3.41 0.2378 99.8 1939.954 1939.961 -3.6 118465.2

IPI:IPI001 11 19 9.60% 1605 172878 9.3 U Tax_Id=10090 Gene_Symbol=Rrbp1 Isoform 3 of Ribosome-binding protein 1 IPI:IPI00 11 19 10.50% 1464 158395 9.2 U Tax_Id=10090 Gene_Symbol=Rrbp1 ribosome binding protein 1 isoform a

FOXO_KO.1 4.6425 0.4561 100 1562.807 1562.809 -1.6 244507FOXO_KO.3 3.56 0.3098 99.9 3095.535 3094.528 1.1 80192.9FOXO_KO.4 3.4756 0.2808 99.7 2971.559 2971.556 1 47588.4FOXO_KO.1 6.8967 0.5131 100 2341.052 2340.052 -1.3 96305.6FOXO_KO.1 5.3433 0.2819 99.9 2341.056 2340.052 0.2 249327.3FOXO_KO.1 6.6736 0.5515 100 2071.866 2070.867 -2.3 152674.6FOXO_KO_w 2.4483 0.2359 99.5 982.5214 982.5204 1.1 170373.6FOXO_KO_w 3.6427 0.3763 100 1360.709 1360.707 1.4 21168.1FOXO_KO_w 4.3312 0.5219 100 1422.684 1422.686 -1.6 36503.1FOXO_KO.2 6.1475 0.529 100 3157.639 3156.638 -0.7 67351FOXO_KO.1 5.4177 0.4424 100 2334.066 2333.071 -3.5 60660.7

IPI:IPI00 9 11 9.60% 677 76222 7 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform E of Fragile X mental retardation syndrome-related protein 1 IPI:IPI00 9 11 10.00% 648 73123 7 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform F of Fragile X mental retardation syndrome-related protein 1 IPI:IPI002 9 11 10.50% 621 69715 6.3 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform D of Fragile X mental retardation syndrome-related protein 1 IPI:IPI00 9 11 10.00% 650 72814 6.3 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform C of Fragile X mental retardation syndrome-related protein 1 IPI:IPI002 9 11 9.60% 677 76207 7.5 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform B of Fragile X mental retardation syndrome-related protein 1 IPI:IPI002 9 11 12.10% 539 60816 6.4 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform A of Fragile X mental retardation syndrome-related protein 1

FOXO_KO.2 7.9356 0.6104 100 2315.072 2314.074 -2 95435.2FOXO_KO.2 3.5969 0.4775 100 2315.078 2314.074 0.3 160825.5FOXO_KO.1 4.7392 0.4774 100 1639.782 1639.781 0.4 170152FOXO_KO.1 3.8776 0.4085 100 1511.684 1511.686 -1.4 200262.4FOXO_KO.5 4.456 0.3264 100 1695.877 1695.874 1.4 96896FOXO_KO.5 3.4301 0.4647 100 1696.879 1695.874 0.8 43149.2FOXO_KO.1 4.1333 0.325 100 1736.78 1735.777 0 134982.9FOXO_KO.1 4.0946 0.3476 100 2121.969 2121.968 0.2 74258.1FOXO_KO.1 4.6472 0.4765 100 2121.966 2121.968 -1.2 155182.5

IPI:IPI00 4 5 9.60% 490 55606 7.1 U Tax_Id=10090 Gene_Symbol=Cyp2c37 cytochrome P450, family 2, subfamily c, polypeptide 37 FOXO_KO.1 4.5717 0.205 99.9 1666.884 1665.881 -0.3 349183.1FOXO_KO.3 6.0988 0.4971 100 2554.208 2553.2 1.5 61882.2FOXO_KO.3 4.6988 0.471 100 2555.21 2553.2 1 267705.8FOXO_KO.1 3.4176 0.3861 100 1280.683 1280.684 -0.9 178111.9

IPI:IPI00 2 2 9.60% 407 44714 8.5 U Tax_Id=10090 Gene_Symbol=Serbp1 Isoform 1 of Plasminogen activator inhibitor 1 RNA-binding protein IPI:IPI00 2 2 9.70% 401 44005 8.5 U Tax_Id=10090 Gene_Symbol=Serbp1 SERPINE1 mRNA binding protein 1 isoform 2 IPI:IPI00 2 2 10.10% 386 42235 8.4 U Tax_Id=10090 Gene_Symbol=Serbp1 Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein IPI:IPI00 2 2 9.90% 392 42944 8.4 U Tax_Id=10090 Gene_Symbol=Serbp1 Isoform 2 of Plasminogen activator inhibitor 1 RNA-binding protein

FOXO_KO.8 3.9796 0.3382 99.9 2113.921 2111.92 -2.7 233113FOXO_KO.2 4.1951 0.4487 100 2103.974 2103.972 1 59214.2

IPI:IPI006 2 2 9.60% 302 34345 8.2 U Tax_Id=10090 Gene_Symbol=LOC639023 similar to cytochrome P450 FOXO_KO.1 3.5051 0.3624 100 1385.68 1385.681 -0.4 236925.7FOXO_KO.3 3.5819 0.2757 99.9 1948.043 1948.039 2.1 202331.4

IPI:IPI00 3 3 9.60% 303 33499 8.3 U Tax_Id=10090 Gene_Symbol=Mtch2 Mitochondrial carrier homolog 2 IPI:IPI00 3 3 9.20% 315 34315 8.7 U Tax_Id=10090 Gene_Symbol=Mtch2 Mtch2 protein (Fragment)

FOXO_KO.1 6.1611 0.5168 100 2455.241 2454.24 -0.8 61869.8FOXO_KO.1 4.5703 0.4321 100 2455.242 2454.24 -0.6 230234.6FOXO_KO.2 4.2853 0.3249 99.9 3427.639 3425.638 -1.6 31419.7

IPI:IPI00 2 5 9.60% 249 26443 9.6 U Tax_Id=10090 Gene_Symbol=Pabpc4 Putative uncharacterized protein IPI:IPI00 2 5 20.30% 118 12702 6 U Tax_Id=10090 Gene_Symbol=Pabpc1 Protein

FOXO_KO.4 6.0407 0.5297 100 2741.394 2740.389 0.6 25547.1FOXO_KO.4 3.6745 0.4621 100 2741.396 2740.389 1.3 45001.9

IPI:IPI00 3 3 9.60% 240 26372 7.8 U Tax_Id=10090 Gene_Symbol=Psmb1 Proteasome subunit beta type-1 * FOXO_KO.1 4.3316 0.3341 100 1665.839 1665.838 1 271611.9* FOXO_KO.1 3.1227 0.3279 99.9 1665.84 1665.838 1.2 207163.2* FOXO_KO.1 2.5408 0.2527 99.6 1007.514 1007.516 -1.2 253667.4IPI:IPI00 1 1 9.60% 178 21139 9.9 U Tax_Id=10090 Gene_Symbol=Nop16 Nucleolar protein 16 IPI:IPI00 1 1 9.40% 181 21509 10 U Tax_Id=10090 Gene_Symbol=Nop16 22 kDa protein

FOXO_KO.1 7.5946 0.4931 100 1902.99 1901.986 0.5 129585.3IPI:IPI00 1 1 9.60% 125 14585 9.4 U Tax_Id=10090 Gene_Symbol=0610009D07Rik Pre-mRNA branch site protein p14 * FOXO_KO.3 3.3336 0.3555 100 1417.683 1416.672 5.7 85282.5IPI:IPI00 1 1 9.50% 296 33944 6.1 U Tax_Id=10090 Gene_Symbol=Opa1 Protein

FOXO_KO.5 3.7961 0.2675 99.7 3260.516 3259.51 0.8 38821.2IPI:IPI00 1 1 9.50% 222 25820 10.3 U Tax_Id=10090 Gene_Symbol=Gadd45gip1 Growth arrest and DNA damage-inducible proteins-interacting protein 1 * FOXO_KO.3 5.3733 0.5444 100 2540.166 2539.166 -1.1 28714.5IPI:IPI002 1 1 9.50% 200 22584 7 U Tax_Id=10090 Gene_Symbol=Camk2a Isoform Alpha KAP of Calcium/calmodulin-dependent protein kinase type II subunit alpha IPI:IPI00 1 1 8.30% 230 26048 6.1 U Tax_Id=10090 Gene_Symbol=Camk2a 26 kDa protein IPI:IPI00 1 1 10.10% 189 21351 6.3 U Tax_Id=10090 Gene_Symbol=Camk2a 21 kDa protein IPI:IPI006 1 1 4.00% 478 54115 7.1 U Tax_Id=10090 Gene_Symbol=Camk2a Isoform Alpha CaMKII of Calcium/calmodulin-dependent protein kinase type II subunit alpha IPI:IPI00 1 1 3.90% 489 55347 7.4 U Tax_Id=10090 Gene_Symbol=Camk2a MKIAA0968 protein

FOXO_KO.3 6.0376 0.4217 100 2145.043 2144.039 0 113913.5IPI:IPI002 1 1 9.50% 105 12215 11.4 U Tax_Id=10090 Gene_Symbol=Rpl36 60S ribosomal protein L36 IPI:IPI00 1 1 11.60% 86 10024 11.8 U Tax_Id=10090 Gene_Symbol=- 10 kDa protein IPI:IPI00 1 1 9.50% 105 12254 11.6 U Tax_Id=10090 Gene_Symbol=LOC100048508;Rpl36 ribosomal protein L36 IPI:IPI00 1 1 9.50% 105 12256 11.4 U Tax_Id=10090 Gene_Symbol=LOC100045157;Gm10168 hypothetical protein IPI:IPI00 1 1 9.60% 104 12130 11.4 U Tax_Id=10090 Gene_Symbol=Gm5745 hypothetical protein

FOXO_KO.1 3.1383 0.3672 100 1229.552 1227.546 -1.2 670798.8

IPI:IPI00 5 7 9.40% 1023 112982 5.5 U Tax_Id=10090 Gene_Symbol=Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 * FOXO_KO.3 4.5795 0.48 100 1816.939 1816.936 1.5 91522.3* FOXO_KO.4 4.7223 0.4502 100 2835.397 2834.384 3.1 12157.4

FOXO_KO.2 5.9796 0.4814 100 1830.931 1829.924 1.9 200967.5* FOXO_KO.2 3.6838 0.3975 100 1436.656 1436.657 -0.7 142548.4* FOXO_KO.3 5.1703 0.4727 100 3106.32 3105.325 -2.5 91694.7IPI:IPI00 4 5 9.40% 790 91927 6.6 U Tax_Id=10090 Gene_Symbol=Ncbp1 Nuclear cap-binding protein subunit 1 * FOXO_KO.2 6.0661 0.4304 100 1962.874 1961.876 -2.4 103702.2* FOXO_KO.1 5.221 0.4736 100 2367.008 2366.006 -0.6 140964.4* FOXO_KO.3 4.1872 0.453 100 2508.125 2507.118 1.2 189253.9* FOXO_KO.1 4.3314 0.4834 100 1832.776 1831.773 -0.1 90375.3IPI:IPI00 2 2 9.40% 545 60630 6.7 U Tax_Id=10090 Gene_Symbol=Cct3 T-complex protein 1 subunit gamma * FOXO_KO.4 3.9294 0.3919 99.9 3427.756 3426.753 -0.1 89981.3* FOXO_KO.2 4.1388 0.2991 99.9 2497.33 2496.33 -1.5 282448.6IPI:IPI00 5 24 9.40% 520 59093 7.9 U Tax_Id=10090 Gene_Symbol=Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 IPI:IPI00 5 24 10.00% 491 56145 7.4 U Tax_Id=10090 Gene_Symbol=Cyp2c67 Putative uncharacterized protein

FOXO_KO.2 3.2254 0.3837 100 1135.638 1135.636 1.7 236375.4FOXO_KO.3 5.1299 0.2829 100 1666.839 1666.84 -0.1 24365.1FOXO_KO.3 3.9353 0.235 99.9 1667.842 1666.84 -0.5 53614.2FOXO_KO.3 3.5154 0.2442 99.9 1330.689 1329.684 1.2 247303.6FOXO_KO.1 2.5524 0.2931 99.5 1826.838 1826.843 -2.3 246023.8

IPI:IPI00 4 4 9.40% 489 52631 9 U Tax_Id=10090 Gene_Symbol=Ptbp1 MCG13402, isoform CRA_d FOXO_KO.1 5.3042 0.4978 100 2116.988 2116.989 -0.6 49265FOXO_KO.1 2.8908 0.27 99.5 2116.99 2116.989 0.3 137424.6FOXO_KO_w 2.477 0.324 99.8 1031.49 1031.491 -0.7 101686.3FOXO_KO.3 3.9508 0.2988 99.9 2981.515 2980.505 2.1 113157.8

IPI:IPI00 6 8 9.30% 841 94133 5.2 U Tax_Id=10090 Gene_Symbol=Hspa4 Heat shock 70 kDa protein 4 * FOXO_KO.1 3.5048 0.3002 99.9 1495.702 1495.702 -0.1 295994.1* FOXO_KO.2 3.539 0.4672 100 1403.632 1402.631 -1.2 146332.8* FOXO_KO.9 3.9794 0.4058 100 1875.87 1875.872 -0.9 481962* FOXO_KO.1 4.7175 0.3905 100 2233.08 2232.078 -0.7 199558.1* FOXO_KO.1 4.5345 0.272 99.9 2233.082 2232.078 0.1 408120.9* FOXO_KO.9 6.1564 0.467 100 3330.426 3328.433 -4.1 132214.2IPI:IPI00 2 2 9.30% 354 39765 8.7 U Tax_Id=10090 Gene_Symbol=Otc Ornithine carbamoyltransferase, mitochondrial IPI:IPI00 2 2 9.40% 351 39365 8.7 U Tax_Id=10090 Gene_Symbol=Otc Otc protein

FOXO_KO.3 4.7821 0.3524 100 2093.99 2092.986 0.5 96951.2FOXO_KO.1 5.6382 0.5165 100 1709.8 1709.802 -1.1 209260.4

IPI:IPI00 1 1 9.30% 205 22678 6.2 U Tax_Id=10090 Gene_Symbol=Rab1 Ras-related protein Rab-1A IPI:IPI00 1 1 15.10% 126 13598 5.6 U Tax_Id=10090 Gene_Symbol=Rab1 RAB1, member RAS oncogene family IPI:IPI00 1 1 9.50% 201 22187 5.7 U Tax_Id=10090 Gene_Symbol=Rab1b Ras-related protein Rab-1B

FOXO_KO.3 4.1112 0.1778 99.8 2174.004 2172.002 -2.1 85911.1IPI:IPI00 3 5 9.20% 490 55674 7.6 U Tax_Id=10090 Gene_Symbol=Cyp2c50 Isoform 1 of Cytochrome P450 2C50

FOXO_KO.1 4.5717 0.205 99.9 1666.884 1665.881 -0.3 349183.1* FOXO_KO.3 5.8816 0.4593 100 2319.101 2318.097 -0.1 72346.7

FOXO_KO.1 3.4176 0.3861 100 1280.683 1280.684 -0.9 178111.9IPI:IPI00 2 3 9.20% 436 49784 7.8 U Tax_Id=10090 Gene_Symbol=Bysl Bystin * FOXO_KO.2 5.3939 0.4611 100 2522.076 2521.065 2.7 22255.1* FOXO_KO.1 5.2955 0.4011 100 2009.921 2009.923 -1.1 89304.3

IPI:IPI001 2 3 9.20% 401 45389 4.9 U Tax_Id=10090 Gene_Symbol=Prkar2a cAMP-dependent protein kinase type II-alpha regulatory subunit IPI:IPI00 2 3 9.20% 402 45589 4.9 U Tax_Id=10090 Gene_Symbol=Prkar2a Protein kinase, cAMP dependent regulatory, type II alpha, isoform CRA_b

FOXO_KO.4 6.6415 0.488 100 2009.975 2007.969 -0.4 100096.5FOXO_KO.1 6.9576 0.4786 100 2338.025 2337.027 -2 46547.9

IPI:IPI002 1 1 9.20% 272 30629 6 U Tax_Id=10090 Gene_Symbol=Capzb Isoform 2 of F-actin-capping protein subunit beta IPI:IPI00 1 1 12.30% 204 22841 6.2 U Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta IPI:IPI00 1 1 22.70% 110 12632 4.7 U Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta IPI:IPI00 1 1 9.60% 260 29295 6.9 U Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_a IPI:IPI00 1 1 13.30% 188 21069 4.8 U Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta IPI:IPI00 1 1 8.30% 301 33767 6.4 U Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta IPI:IPI004 1 1 9.00% 277 31345 5.7 U Tax_Id=10090 Gene_Symbol=Capzb Isoform 1 of F-actin-capping protein subunit beta

FOXO_KO.5 2.5117 0.3029 99.6 2783.438 2783.438 -0.1 9021.8IPI:IPI00 1 1 9.20% 206 23035 5.4 U Tax_Id=10090 Gene_Symbol=Rab18 Ras-related protein Rab-18 * FOXO_KO.3 4.0033 0.4201 100 2103.987 2101.996 -7.7 82404.7IPI:IPI00 1 1 9.20% 196 22988 9.5 U Tax_Id=10090 Gene_Symbol=Rer1 Protein RER1 * FOXO_KO.1 5.0181 0.4902 100 1902.865 1902.864 0.7 104813.5IPI:IPI00 1 2 9.20% 173 18966 9.4 U Tax_Id=10090 Gene_Symbol=Hadhb 19 kDa protein

FOXO_KO.4 4.7157 0.3591 100 1838.999 1837.995 0.8 47714.7IPI:IPI00 1 1 9.20% 152 16292 6.5 U Tax_Id=10090 Gene_Symbol=Glrx5 Glutaredoxin-related protein 5, mitochondrial * FOXO_KO.2 4.4724 0.391 100 1653.777 1653.776 1 151309.9IPI:IPI001 3 10 9.10% 438 48647 8.6 U Tax_Id=10090 Gene_Symbol=Gcdh Glutaryl-CoA dehydrogenase, mitochondrial IPI:IPI00 3 10 9.10% 438 48606 8.7 U Tax_Id=10090 Gene_Symbol=Gcdh glutaryl-Coenzyme A dehydrogenase precursor


IPI:IPI00 2 2 9.10% 418 47357 5.9 U Tax_Id=10090 Gene_Symbol=Actr3 Actin-related protein 3 * FOXO_KO.3 6.7004 0.5447 100 2445.191 2444.187 0.3 104990* FOXO_KO.1 3.9081 0.4073 100 1768.907 1768.908 -0.6 169618.7IPI:IPI00 1 1 9.10% 297 33097 6.5 U Tax_Id=10090 Gene_Symbol=Mpst 3-mercaptopyruvate sulfurtransferase * FOXO_KO.3 4.9048 0.3444 99.9 2912.46 2910.452 0.3 90680.6IPI:IPI00 1 3 9.10% 264 29116 5.7 U Tax_Id=10090 Gene_Symbol=Psmb4 Proteasome subunit beta type-4 * FOXO_KO.4 5.1406 0.3729 100 2602.233 2601.229 0.1 35549IPI:IPI00 2 3 9.00% 691 77747 6.7 U Tax_Id=10090 Gene_Symbol=Nsun2 Isoform 2 of tRNA (cytosine-5-)-methyltransferase NSUN2 IPI:IPI00 2 3 8.20% 757 85452 6.6 U Tax_Id=10090 Gene_Symbol=Nsun2 Isoform 1 of tRNA (cytosine-5-)-methyltransferase NSUN2

FOXO_KO.1 4.7691 0.2478 99.9 4490.949 4488.945 -0.6 46060.7FOXO_KO.4 4.008 0.3398 100 2245.114 2244.111 -0.3 127569.3

IPI:IPI00 4 4 9.00% 612 70915 5.4 U Tax_Id=10090 Gene_Symbol=Hsp90b1 Putative uncharacterized protein FOXO_KO.2 3.7471 0.5007 100 1525.725 1525.727 -1.3 209186FOXO_KO.3 3.3502 0.2514 99.5 3077.491 3076.486 0.4 85160.6FOXO_KO.3 6.0152 0.6256 100 3233.592 3232.587 0.4 125543.2FOXO_KO.3 5.0228 0.4502 100 1864.913 1864.915 -1 193083.2

IPI:IPI002 1 1 9.00% 245 27923 8.7 U Tax_Id=10090 Gene_Symbol=Bcap31 B-cell receptor-associated protein 31 IPI:IPI00 1 1 9.00% 245 27957 8.7 U Tax_Id=10090 Gene_Symbol=Bcap31 B-cell receptor-associated protein 31, isoform CRA_c

FOXO_KO.1 4.9729 0.3847 100 2377.116 2377.119 -1.1 161799.4IPI:IPI00 2 3 9.00% 210 24597 10 U Tax_Id=10090 Gene_Symbol=Rpl13 60S ribosomal protein L13 IPI:IPI00 2 3 10.20% 187 21660 11.1 U Tax_Id=10090 Gene_Symbol=- 22 kDa protein

FOXO_KO.2 2.6936 0.2223 99.7 950.4943 950.4941 0.2 242881.9FOXO_KO_w 4.0975 0.3839 100 1232.62 1232.623 -2.3 98539.8

IPI:IPI006 2 2 9.00% 145 16824 10 U Tax_Id=10090 Gene_Symbol=Gm6921 similar to insulinoma protein IPI:IPI006 2 2 9.00% 145 16893 10 U Tax_Id=10090 Gene_Symbol=- similar to insulinoma protein

FOXO_KO_w 4.0933 0.4277 100 1481.801 1481.803 -1.3 52404.4FOXO_KO.8 3.4335 0.3056 99.9 1353.704 1353.708 -3 284062

IPI:IPI00 2 2 8.90% 527 56478 8.3 U Tax_Id=10090 Gene_Symbol=Ptbp1 Polypyrimidine tract-binding protein 1 FOXO_KO.3 3.2616 0.2887 99.7 2087.148 2086.143 1 109512.6FOXO_KO.3 3.9508 0.2988 99.9 2981.515 2980.505 2.1 113157.8

IPI:IPI00 2 3 8.90% 450 49960 5.1 U Tax_Id=10090 Gene_Symbol=Tuba3b;Tuba3a Tubulin alpha-3 chain FOXO_KO.2 4.5509 0.5166 100 2007.894 2007.893 0.4 80478FOXO_KO.2 6.2379 0.5428 100 2332.023 2330.018 -0.8 163114

IPI:IPI00 2 3 8.90% 448 49924 5.1 U Tax_Id=10090 Gene_Symbol=Tuba4a Tubulin alpha-4A chain * FOXO_KO.2 4.2525 0.3467 100 2068.884 2067.897 -7.6 79008.1

FOXO_KO.2 6.2379 0.5428 100 2332.023 2330.018 -0.8 163114IPI:IPI003 3 3 8.90% 426 48327 5.3 U Tax_Id=10090 Gene_Symbol=Zc3h15 Isoform 1 of Zinc finger CCCH domain-containing protein 15 IPI:IPI008 3 3 17.20% 221 24835 4.4 U Tax_Id=10090 Gene_Symbol=Zc3h15 Isoform 2 of Zinc finger CCCH domain-containing protein 15

FOXO_KO.2 4.399 0.2602 99.9 2104.091 2103.082 2.7 166558.6FOXO_KO.2 5.3023 0.2472 100 2541.113 2540.106 1.6 52134.8FOXO_KO.2 4.6646 0.4799 100 2540.101 2540.106 -1.8 390885.1

IPI:IPI001 4 11 8.80% 480 52769 6.1 U Tax_Id=10090 Gene_Symbol=Uqcrc1 Cytochrome b-c1 complex subunit 1, mitochondrial IPI:IPI00 4 11 8.80% 480 52852 6.2 U Tax_Id=10090 Gene_Symbol=Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 precursor

FOXO_KO.3 6.0678 0.5161 100 2331.203 2329.213 -7.4 120044.7FOXO_KO.3 6.6232 0.4624 100 2615.357 2614.357 -1.4 47092.7FOXO_KO.3 4.2849 0.3762 99.9 2615.358 2614.357 -0.8 201349.7FOXO_KO.1 6.7842 0.5429 100 2054.999 2053.997 -0.8 158006.2

IPI:IPI001 3 3 8.80% 442 49493 5.2 U Tax_Id=10090 Gene_Symbol=Psmc3 26S protease regulatory subunit 6A FOXO_KO.3 4.6665 0.3799 100 2120.99 2119.985 0.5 112914.8FOXO_KO.1 6.7312 0.5144 100 2254.034 2253.034 -1.6 157378.4FOXO_KO.1 3.2464 0.2987 99.8 2254.034 2253.034 -1.5 454573.5

IPI:IPI004 3 4 8.80% 329 34699 7.7 U Tax_Id=10090 Gene_Symbol=Hnrnpl Putative uncharacterized protein FOXO_KO.6 4.34 0.4568 100 3088.638 3087.632 0.6 7613.7FOXO_KO.6 6.3441 0.5629 100 3089.638 3087.632 -0.2 79344.5FOXO_KO.6 7.4 0.5366 100 3088.638 3087.632 0.9 182842.8

IPI:IPI00 2 2 8.80% 297 34401 9.8 U Tax_Id=10090 Gene_Symbol=Rpl5;Gm15500 60S ribosomal protein L5 FOXO_KO.1 2.7544 0.3178 99.9 1533.677 1533.678 -0.8 253192.6

* FOXO_KO.1 3.4731 0.2282 99.8 1729.758 1729.759 -0.8 149733.6IPI:IPI00 1 1 8.80% 273 28370 6.1 U Tax_Id=10090 Gene_Symbol=Exosc6 Exosome complex exonuclease MTR3 * FOXO_KO.1 5.3877 0.5784 100 2641.253 2640.254 -1.5 116418IPI:IPI001 2 2 8.80% 238 27378 11.8 U Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 2 of Splicing factor, arginine/serine-rich 7 IPI:IPI00 2 2 9.30% 226 26023 11.8 U Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 4 of Splicing factor, arginine/serine-rich 7 IPI:IPI004 2 2 13.40% 157 17890 9.5 U Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 3 of Splicing factor, arginine/serine-rich 7 IPI:IPI00 2 2 7.90% 267 30818 11.9 U Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 1 of Splicing factor, arginine/serine-rich 7

FOXO_KO.2 3.9775 0.1693 99.8 2379.108 2378.105 -0.2 123360.9FOXO_KO.2 3.751 0.2284 99.5 2379.104 2378.105 -1.6 1580633

IPI:IPI00 2 2 8.80% 204 22687 6.5 U Tax_Id=10090 Gene_Symbol=0610011F06Rik UPF0585 protein C16orf13 homolog * FOXO_KO.4 5.2265 0.4247 100 1943.052 1942.049 -0.3 98149* FOXO_KO.4 6.0849 0.4407 100 1943.053 1942.049 0.5 181494.1IPI:IPI00 1 1 8.80% 181 20412 5.7 U Tax_Id=10090 Gene_Symbol=Arl1 ADP-ribosylation factor-like protein 1 IPI:IPI00 1 1 8.80% 181 20484 5.4 U Tax_Id=10090 Gene_Symbol=Arl1 Putative uncharacterized protein

FOXO_KO.5 4.8245 0.5058 100 1791.886 1791.883 1.7 104952.4IPI:IPI00 1 2 8.80% 181 19965 7.2 U Tax_Id=10090 Gene_Symbol=Ahcyl2 20 kDa protein

FOXO_KO.3 4.1107 0.3332 100 1844.921 1843.929 -6.1 77601.9IPI:IPI00 4 7 8.70% 1271 144803 6.1 U Tax_Id=10090 Gene_Symbol=Flii Protein flightless-1 homolog * FOXO_KO.3 6.1445 0.5638 100 3298.616 3297.606 2.1 91424.4* FOXO_KO.5 4.2945 0.2624 99.9 3561.602 3560.602 -1 28240.4* FOXO_KO.1 5.0697 0.5042 100 2389.098 2387.093 -0.7 86969.3* FOXO_KO.3 5.1466 0.3727 100 3618.644 3618.637 1.9 37656.4IPI:IPI00 6 9 8.70% 892 103068 5.4 U Tax_Id=10090 Gene_Symbol=Actn1 Alpha-actinin-1 * FOXO_KO.1 3.3165 0.3082 99.9 1761.857 1759.853 -1.3 293557.4* FOXO_KO.2 6.1394 0.4204 100 2051.957 2051.959 -1.2 167853.9* FOXO_KO.5 5.5574 0.4774 100 3249.619 3248.614 0.4 46876.9

FOXO_KO_w 6.4706 0.575 100 1754.827 1753.825 -0.7 24820.2* FOXO_KO.3 7.339 0.3879 100 2444.202 2442.197 -0.5 74118.6* FOXO_KO.3 5.4432 0.2929 99.9 2444.2 2442.197 -1.7 236632.8IPI:IPI00 3 3 8.70% 704 80885 6.9 U Tax_Id=10090 Gene_Symbol=Gys2 Glycogen [starch] synthase, liver IPI:IPI00 3 3 8.70% 704 80871 6.9 U Tax_Id=10090 Gene_Symbol=Gys2 glycogen synthase 2 IPI:IPI006 3 3 10.10% 603 68762 6.6 U Tax_Id=10090 Gene_Symbol=LOC633620 similar to Glycogen synthase 2


IPI:IPI00 2 2 8.70% 425 47790 5 U Tax_Id=10090 Gene_Symbol=Rbbp7 Histone-binding protein RBBP7 IPI:IPI00 2 2 8.90% 416 46908 5.1 U Tax_Id=10090 Gene_Symbol=Rbbp7 Retinoblastoma binding protein 7

FOXO_KO.1 2.4218 0.3388 99.8 1284.54 1284.541 -1.3 249218FOXO_KO.2 3.3899 0.2492 99.5 2847.341 2847.343 -0.6 84370.9

IPI:IPI00 1 2 8.70% 393 43387 6.4 U Tax_Id=10090 Gene_Symbol=Ighg1 Ig gamma-1 chain C region, membrane-bound form IPI:IPI008 1 2 10.50% 324 35705 7.4 U Tax_Id=10090 Gene_Symbol=Ighg1 Ig gamma-1 chain C region secreted form IPI:IPI00 1 2 7.30% 463 51008 7 U Tax_Id=10090 Gene_Symbol=Ighg1 Igh protein

FOXO_KO.3 6.1115 0.528 100 3947.905 3945.896 0.5 40034.1IPI:IPI00 1 1 8.70% 231 26292 7.1 U Tax_Id=10090 Gene_Symbol=Myh10 Putative uncharacterized protein IPI:IPI00 1 1 16.70% 120 13579 5.6 U Tax_Id=10090 Gene_Symbol=Myh9 14 kDa protein

FOXO_KO.2 5.5851 0.4271 100 2288.117 2286.11 0.2 60350.5IPI:IPI00 1 1 8.70% 231 25711 6.5 U Tax_Id=10090 Gene_Symbol=Scp2 Sterol carrier protein 2, liver

FOXO_KO.3 6.5819 0.5748 100 2269.082 2268.077 0.6 109938.8IPI:IPI00 1 1 8.70% 149 17126 8.8 U Tax_Id=10090 Gene_Symbol=- Modified fragile X mental retardation protein (Fragment)

FOXO_KO.1 4.9082 0.4305 100 1556.696 1554.692 -1.7 187866.9IPI:IPI00 2 3 8.60% 718 79602 6.5 U Tax_Id=10090 Gene_Symbol=Larp4 La ribonucleoprotein domain family, member 4 isoform 2 IPI:IPI00 2 3 8.60% 719 79763 6.4 U Tax_Id=10090 Gene_Symbol=Larp4 La-related protein 4

FOXO_KO.4 4.6862 0.3129 99.9 3215.583 3213.585 -2.5 69076.5FOXO_KO.1 4.3694 0.399 99.9 3640.751 3638.752 -2.2 31840.2

IPI:IPI00 5 6 8.60% 558 61337 8 U Tax_Id=10090 Gene_Symbol=Glud1 Glutamate dehydrogenase 1, mitochondrial * FOXO_KO.2 4.3601 0.4069 100 1515.825 1515.826 -1 294297.5* FOXO_KO.1 4.5248 0.4319 100 1582.731 1581.729 -1.3 174142.3* FOXO_KO.2 4.3336 0.4043 100 1425.631 1425.628 2.1 408189.8* FOXO_KO.3 6.7919 0.4855 100 2294.131 2293.127 0.6 88857.2* FOXO_KO.3 3.6501 0.2216 99.5 2293.128 2293.127 0.4 100677.9IPI:IPI00 3 4 8.60% 501 55587 4.8 U Tax_Id=10090 Gene_Symbol=Pwp1 Periodic tryptophan protein 1 homolog

FOXO_KO.2 4.5882 0.3109 99.9 2793.325 2792.32 0.7 96027.8

* FOXO_KO.1 3.1315 0.248 99.8 2141.896 2141.899 -1.7 38482.5* FOXO_KO.1 4.4405 0.3398 100 2142.899 2141.899 -1.7 44341.5IPI:IPI00 2 2 8.60% 257 30170 9.3 U Tax_Id=10090 Gene_Symbol=Mrpl28 39S ribosomal protein L28, mitochondrial * FOXO_KO.5 5.5085 0.5521 100 2461.253 2460.254 -2.1 35694.9* FOXO_KO.5 4.7001 0.4707 100 2461.266 2460.254 3.5 129971.7IPI:IPI00 1 1 8.60% 175 20082 9 U Tax_Id=10090 Gene_Symbol=Arf6 ADP-ribosylation factor 6 * FOXO_KO.1 3.4678 0.3832 100 1778.876 1778.874 0.8 98365IPI:IPI00 1 1 8.60% 175 19023 4.8 U Tax_Id=10090 Gene_Symbol=Npm3 Nucleoplasmin-3 IPI:IPI006 1 1 9.10% 164 18252 5.6 U Tax_Id=10090 Gene_Symbol=LOC639633 similar to nucleophosmin/nucleoplasmin-3

FOXO_KO.1 4.7522 0.5226 100 1690.849 1690.851 -1.1 249828.4IPI:IPI00 1 2 8.60% 93 10608 8.4 U Tax_Id=10090 Gene_Symbol=Caprin1 Cell cycle associated protein 1 IPI:IPI00 1 2 2.30% 345 37943 5 U Tax_Id=10090 Gene_Symbol=Caprin1 38 kDa protein

FOXO_KO_w 2.9457 0.2176 99.8 999.4523 999.453 -0.7 27421.6IPI:IPI00 8 9 8.50% 870 100286 10 U Tax_Id=10090 Gene_Symbol=Bclaf1 BCL2-associated transcription factor 1 isoform 3

FOXO_KO.1 4.5407 0.4167 100 2609.134 2608.132 -0.5 45304.1FOXO_KO.1 4.6586 0.471 100 2609.133 2608.132 -1 118054.3FOXO_KO.2 4.9197 0.2557 99.9 2728.123 2726.125 -3.4 102916.3FOXO_KO.2 4.3728 0.4747 100 2514.004 2513.003 -0.8 45204.6FOXO_KO.2 4.6611 0.31 99.9 2514.003 2513.003 -1 170313.3FOXO_KO.2 4.0437 0.406 100 1666.823 1666.824 -0.7 228161.3FOXO_KO.2 3.369 0.3047 99.9 1666.822 1666.824 -1.4 75690.3

* FOXO_KO.1 3.6347 0.3228 99.9 1897.812 1896.815 -3.2 139098.7IPI:IPI00 3 3 8.50% 424 43995 8.5 U Tax_Id=10090 Gene_Symbol=Acaa1a;Acaa1b 3-ketoacyl-CoA thiolase B, peroxisomal * FOXO_KO.6 7.8343 0.4197 100 2130.145 2128.138 -0.1 129328.7* FOXO_KO.6 3.311 0.4332 99.9 2128.142 2128.138 1.7 73717* FOXO_KO.2 3.3032 0.3383 99.9 1804.854 1804.857 -1.6 64712IPI:IPI00 2 3 8.50% 424 43953 8.4 U Tax_Id=10090 Gene_Symbol=Acaa1a;Acaa1b 3-ketoacyl-CoA thiolase A, peroxisomal * FOXO_KO.5 8.0229 0.4133 100 2157.167 2155.16 -0.1 99941.3

FOXO_KO.1 3.9699 0.3514 100 1810.774 1810.777 -1.6 143707IPI:IPI00 3 3 8.50% 246 27766 10.4 U Tax_Id=10090 Gene_Symbol=LOC100047006 similar to Ribosomal protein L7a

FOXO_KO.1 4.595 0.3416 99.9 2270.148 2269.149 -1.8 170991FOXO_KO.1 3.9658 0.3856 100 1700.776 1700.78 -1.9 354713.2FOXO_KO.1 5.6731 0.6061 100 2141.05 2141.054 -2.1 62213.7

IPI:IPI004 5 5 8.40% 573 61055 6.4 U Tax_Id=10090 Gene_Symbol=Gm12141 similar to Heat shock protein 1 FOXO_KO.3 4.4619 0.4147 100 1505.757 1504.756 -2 391997.8FOXO_KO.3 5.6505 0.4459 100 1923.955 1922.953 -0.5 194460.2FOXO_KO.3 3.0483 0.2823 99.7 1922.95 1922.953 -1.3 163719.2FOXO_KO.2 3.4659 0.4296 100 1601.751 1601.752 -0.2 350550.5FOXO_KO.2 6.1171 0.3609 100 2298.146 2297.139 1.2 133837.8

IPI:IPI00 2 3 8.40% 321 36777 6.5 U Tax_Id=10090 Gene_Symbol=Lrrfip1 Putative uncharacterized protein (Fragment) FOXO_KO.1 3.2566 0.236 99.8 1389.71 1389.711 -0.7 175482FOXO_KO.3 4.032 0.4134 100 1803.88 1803.879 0.2 146258.9

IPI:IPI00 2 2 8.40% 335 36214 8.9 U Tax_Id=10090 Gene_Symbol=Decr1 2,4-dienoyl-CoA reductase, mitochondrial * FOXO_KO.3 4.6334 0.5133 100 1874.882 1874.881 0.6 133793.4* FOXO_KO.3 3.1983 0.2977 99.9 1372.711 1372.711 0.5 194067.3IPI:IPI00 1 1 8.40% 299 33738 5.4 U Tax_Id=10090 Gene_Symbol=Myo1b 34 kDa protein

FOXO_KO.6 3.7991 0.3564 99.9 2668.423 2666.422 -2.1 38697.9IPI:IPI00 1 1 8.40% 155 17808 10.1 U Tax_Id=10090 Gene_Symbol=Gm5116 similar to ribosomal protein L23a

IPI:IPI00 1 1 8.70% 149 16918 10.3 U Tax_Id=10090 Gene_Symbol=- 17 kDa protein IPI:IPI00 1 1 8.30% 156 17698 10.4 U Tax_Id=10090 Gene_Symbol=Gm3174;LOC100046821 similar to ribosomal protein L23a IPI:IPI00 1 1 12.40% 105 12151 9.9 U Tax_Id=10090 Gene_Symbol=LOC100048108 similar to ribosomal protein L23a IPI:IPI008 1 1 8.30% 156 17725 10.3 U Tax_Id=10090 Gene_Symbol=Gm3362 similar to ribosomal protein L23a IPI:IPI00 1 1 9.10% 143 16225 10.3 U Tax_Id=10090 Gene_Symbol=Gm3940 similar to ribosomal protein L23a IPI:IPI00 1 1 8.40% 155 17470 10.1 U Tax_Id=10090 Gene_Symbol=Gm8290 similar to ribosomal protein L23a IPI:IPI00 1 1 8.30% 156 17725 10.4 U Tax_Id=10090 Gene_Symbol=Gm10335 similar to ribosomal protein L23a IPI:IPI00 1 1 8.40% 155 17727 10.4 U Tax_Id=10090 Gene_Symbol=Gm8137;Gm8264 similar to ribosomal protein L23a IPI:IPI00 1 1 8.40% 155 17748 10.3 U Tax_Id=10090 Gene_Symbol=Gm8158;Gm8112 similar to ribosomal protein L23a IPI:IPI006 1 1 7.90% 165 19147 10.3 U Tax_Id=10090 Gene_Symbol=LOC639294 similar to ribosomal protein L23a IPI:IPI00 1 1 8.40% 155 17838 10.1 U Tax_Id=10090 Gene_Symbol=Gm6666 similar to ribosomal protein L23a IPI:IPI00 1 1 8.40% 155 17854 10.3 U Tax_Id=10090 Gene_Symbol=Gm6003 similar to ribosomal protein L23a IPI:IPI00 1 1 8.30% 156 17695 10.4 U Tax_Id=10090 Gene_Symbol=Rpl23a;Gm10132 60S ribosomal protein L23a

FOXO_KO.1 4.2035 0.3897 100 1405.703 1404.701 -0.7 906715.2IPI:IPI00 4 4 8.30% 530 60453 7.4 U Tax_Id=10090 Gene_Symbol=Cald1 caldesmon 1 IPI:IPI00 4 4 7.90% 554 63335 7.8 U Tax_Id=10090 Gene_Symbol=Cald1 63 kDa protein IPI:IPI00 4 4 8.20% 536 61837 6.9 U Tax_Id=10090 Gene_Symbol=Cald1 62 kDa protein IPI:IPI00 4 4 8.20% 534 61652 6.9 U Tax_Id=10090 Gene_Symbol=Cald1 62 kDa protein

FOXO_KO.1 3.5139 0.2415 99.8 1637.837 1637.838 -0.8 166003.7FOXO_KO.1 3.5132 0.4224 100 1337.684 1337.684 0.2 210379.4FOXO_KO.3 4.6917 0.381 100 1643.786 1643.787 -0.7 26534.5FOXO_KO.1 3.5826 0.2088 99.8 1528.823 1528.822 1 206314.9

IPI:IPI00 3 3 8.30% 432 48058 8.1 U Tax_Id=10090 Gene_Symbol=Cmas Isoform 1 of N-acylneuraminate cytidylyltransferase IPI:IPI005 3 3 18.00% 200 22277 6 U Tax_Id=10090 Gene_Symbol=Cmas Isoform 2 of N-acylneuraminate cytidylyltransferase

FOXO_KO.2 4.1194 0.217 99.7 2209.058 2208.057 -0.7 202752FOXO_KO.1 3.9171 0.4364 100 1854.839 1854.843 -2.2 85632FOXO_KO.1 5.4333 0.435 100 2011.945 2010.944 -0.9 111630.3

IPI:IPI00 2 2 8.30% 289 33378 4.3 U Tax_Id=10090 Gene_Symbol=Set;Gm9531 Isoform 1 of Protein SET IPI:IPI00 2 2 9.40% 255 29530 4.4 U Tax_Id=10090 Gene_Symbol=Gm9531 similar to protein phosphatase 2A inhibitor-2 I-2PP2A isoform 2 IPI:IPI00 2 2 7.90% 305 35309 4.4 U Tax_Id=10090 Gene_Symbol=LOC100047898 similar to protein phosphatase 2A inhibitor-2 I-2PP2A IPI:IPI00 2 2 11.20% 215 24924 5.6 U Tax_Id=10090 Gene_Symbol=Set SET translocation IPI:IPI00 2 2 15.90% 151 17584 5.2 U Tax_Id=10090 Gene_Symbol=Set SET translocation IPI:IPI00 2 2 8.70% 277 32105 4.2 U Tax_Id=10090 Gene_Symbol=Set Isoform 2 of Protein SET IPI:IPI00 2 2 8.30% 289 33340 4.4 U Tax_Id=10090 Gene_Symbol=BC085271 cDNA sequence BC085271

FOXO_KO.1 2.7082 0.2389 99.6 1208.601 1208.605 -2.6 324100FOXO_KO.3 3.602 0.2932 99.9 1840.805 1840.806 -0.5 67361.9

IPI:IPI00 1 1 8.30% 264 29460 6.4 U Tax_Id=10090 Gene_Symbol=Inmt Indolethylamine N-methyltransferase * FOXO_KO.2 3.5084 0.3556 99.9 2548.156 2547.157 -1.6 108295.1IPI:IPI002 2 2 8.30% 242 26981 7.6 U Tax_Id=10090 Gene_Symbol=Gm4852 similar to mDj4

FOXO_KO.5 6.019 0.4819 100 2360.979 2360.977 0.8 82783.5FOXO_KO.4 4.053 0.3198 99.9 2518.085 2517.078 1.2 149713.8

IPI:IPI00 1 1 8.30% 228 26305 5.3 U Tax_Id=10090 Gene_Symbol=Usp15 Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 IPI:IPI00 1 1 8.40% 227 26357 5.6 U Tax_Id=10090 Gene_Symbol=Usp15 Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 15

FOXO_KO.4 4.7857 0.2798 100 2299.172 2298.165 1.6 74908.2IPI:IPI00 1 1 8.30% 181 20746 6.6 U Tax_Id=10090 Gene_Symbol=Arf2 ADP-ribosylation factor 2 IPI:IPI00 1 1 10.60% 141 15796 4.9 U Tax_Id=10090 Gene_Symbol=Arf2 ADP-ribosylation factor 2 IPI:IPI00 1 1 8.30% 181 20601 7.4 U Tax_Id=10090 Gene_Symbol=Arf3 ADP-ribosylation factor 3 IPI:IPI00 1 1 8.30% 181 20697 6.8 U Tax_Id=10090 Gene_Symbol=Arf1 ADP-ribosylation factor 1

FOXO_KO.1 4.3996 0.4214 100 1630.771 1630.774 -2 295658.1IPI:IPI004 3 6 8.20% 536 60613 6.1 U Tax_Id=10090 Gene_Symbol=Ephx2 Isoform 2 of Epoxide hydrolase 2

FOXO_KO.4 6.338 0.5374 100 2377.05 2375.042 0.5 109994FOXO_KO.3 5.0663 0.3758 100 2673.336 2671.329 0 54185.2FOXO_KO.3 3.8529 0.2647 99.8 2672.338 2671.329 2.1 108549.1

IPI:IPI00 2 3 8.20% 500 56976 6.6 U Tax_Id=10090 Gene_Symbol=Cyp2d26 Cytochrome P450 2D26 * FOXO_KO.5 5.6471 0.3669 100 3063.602 3061.591 1.2 98275.1

FOXO_KO.3 3.7547 0.4797 100 1350.677 1350.679 -1.5 215934.6IPI:IPI00 3 3 8.20% 490 55858 7.5 U Tax_Id=10090 Gene_Symbol=Cyp2c54 Cytochrome P450 2C54


IPI:IPI00 2 2 8.20% 355 41423 5.2 U Tax_Id=10090 Gene_Symbol=Cald1 H-caldesmon FOXO_KO.9 2.8663 0.3193 99.9 1485.76 1485.766 -3.8 170674.8FOXO_KO.3 4.6917 0.381 100 1643.786 1643.787 -0.7 26534.5

IPI:IPI001 1 2 8.20% 170 18742 7.7 U Tax_Id=10090 Gene_Symbol=Cnbp Isoform 2 of Cellular nucleic acid-binding protein IPI:IPI004 1 2 7.90% 177 19463 7.7 U Tax_Id=10090 Gene_Symbol=Cnbp Isoform 3 of Cellular nucleic acid-binding protein

FOXO_KO.1 4.0505 0.4488 100 1775.64 1775.642 -1.2 185952.5IPI:IPI00 1 1 8.20% 110 12554 10.9 U Tax_Id=10090 Gene_Symbol=Rpl35a;LOC100046034;LOC100044516;Gm10214;Gm10296;Gm13911;Gm10213;Gm15434;mCG_133520 60S ribosomal protein L35a IPI:IPI00 1 1 10.50% 86 9834 10.7 U Tax_Id=10090 Gene_Symbol=LOC100044591 similar to ribosomal protein L35a IPI:IPI00 1 1 7.60% 118 13360 10.2 U Tax_Id=10090 Gene_Symbol=Gm3649 similar to ribosomal protein L35a IPI:IPI00 1 1 6.70% 134 14933 10.3 U Tax_Id=10090 Gene_Symbol=LOC100048640 similar to ribosomal protein L35a IPI:IPI00 1 1 8.20% 110 12550 10.9 U Tax_Id=10090 Gene_Symbol=Gm10247 hypothetical protein IPI:IPI00 1 1 5.60% 160 17963 10.5 U Tax_Id=10090 Gene_Symbol=Gm10237 similar to ribosomal protein L35a

FOXO_KO.1 2.5937 0.4317 100 1101.51 1101.51 -0.3 249779.3IPI:IPI00 4 5 8.10% 484 52867 5.2 U Tax_Id=10090 Gene_Symbol=Krt14 Keratin, type I cytoskeletal 14


IPI:IPI00 3 4 8.10% 447 51692 6.2 U Tax_Id=10090 Gene_Symbol=Ppp2r2a Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform * FOXO_KO.1 3.8545 0.3632 100 1323.68 1321.675 -1.3 363927.4

FOXO_KO.1 2.8864 0.2286 99.6 1332.606 1332.607 -0.5 183744.8FOXO_KO.1 3.6018 0.2533 99.9 1509.743 1509.743 -0.3 209687.9

IPI:IPI00 2 3 8.10% 406 46853 5.3 U Tax_Id=10090 Gene_Symbol=Erp44 Endoplasmic reticulum resident protein 44 * FOXO_KO.2 6.7905 0.4801 100 2067.019 2066.015 0.3 123848.2* FOXO_KO.2 3.4579 0.4013 100 1765.827 1765.824 1.6 92856.2IPI:IPI00 3 3 8.10% 406 45626 7.5 U Tax_Id=10090 Gene_Symbol=Psmc5 26S protease regulatory subunit 8 IPI:IPI00 3 3 9.50% 348 38752 6 U Tax_Id=10090 Gene_Symbol=Psmc5 Psmc5 protein

FOXO_KO.2 5.1927 0.5449 100 1525.728 1524.725 0 241963.6FOXO_KO.3 4.6891 0.0905 99.5 2105.005 2104.002 -0.1 153572.8FOXO_KO.3 4.3049 0.1937 99.7 2105.005 2104.002 0 134010.1

IPI:IPI00 2 3 8.10% 321 34075 9.2 U Tax_Id=10090 Gene_Symbol=Hnrnpa1l2 similar to heterogeneous nuclear ribonucleoprotein A1, isoform 1 IPI:IPI00 2 3 13.50% 193 21484 8.6 U Tax_Id=10090 Gene_Symbol=- 21 kDa protein IPI:IPI008 2 3 8.10% 320 34196 9.2 U Tax_Id=10090 Gene_Symbol=Hnrnpa1 Isoform Long of Heterogeneous nuclear ribonucleoprotein A1 IPI:IPI006 2 3 9.50% 274 29212 8.9 U Tax_Id=10090 Gene_Symbol=Hnrnpa1l2 similar to heterogeneous nuclear ribonucleoprotein A1, isoform 2 IPI:IPI005 2 3 7.00% 373 38804 9.1 U Tax_Id=10090 Gene_Symbol=Hnrnpa1 Putative uncharacterized protein

FOXO_KO.2 3.6829 0.4008 100 1218.637 1218.64 -2 309989.5

FOXO_KO.2 4.3306 0.3434 99.9 1855.857 1855.861 -2.1 157625.2IPI:IPI00 1 1 8.10% 248 27285 7.4 U Tax_Id=10090 Gene_Symbol=Ndufv2 Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial * FOXO_KO.2 3.9575 0.5204 100 2397.063 2397.063 -0.1 54682.5IPI:IPI00 2 2 8.10% 246 26135 4.9 U Tax_Id=10090 Gene_Symbol=Prss3;Gm5771;Tcrb-V20;Prss1;EG436523 protease, serine, 1 * FOXO_KO.2 5.4108 0.2224 100 2213.091 2211.104 -9 178117.7* FOXO_KO.2 4.724 0.1954 99.7 2213.093 2211.104 -8.2 300464IPI:IPI001 1 2 8.10% 222 25533 8.8 U Tax_Id=10090 Gene_Symbol=Gsta2 Glutathione S-transferase A2 IPI:IPI00 1 2 8.10% 222 25483 8.8 U Tax_Id=10090 Gene_Symbol=Gm10639 Glutathione S-transferase IPI:IPI00 1 2 9.90% 182 20936 6 U Tax_Id=10090 Gene_Symbol=Gsta2 21 kDa protein IPI:IPI00 1 2 10.10% 179 20581 5.7 U Tax_Id=10090 Gene_Symbol=Gsta2 21 kDa protein IPI:IPI00 1 2 8.10% 222 25506 8.8 U Tax_Id=10090 Gene_Symbol=Gm10639 hypothetical protein LOC100042314 IPI:IPI00 1 2 8.10% 223 25608 9 U Tax_Id=10090 Gene_Symbol=Gsta1 Glutathione S-transferase A1 IPI:IPI00 1 2 8.10% 222 25542 8.8 U Tax_Id=10090 Gene_Symbol=Gsta2 glutathione S-transferase, alpha 2 IPI:IPI00 1 2 8.10% 223 25582 9 U Tax_Id=10090 Gene_Symbol=Gm3776;Gsta1 Glutathione S-transferase

FOXO_KO.3 4.9339 0.3937 100 2039.924 2038.928 -3.8 104782.4IPI:IPI00 1 1 8.10% 221 24488 5.1 U Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 5 of Dynamin-1-like protein

FOXO_KO.3 4.1147 0.1407 99.6 2301.067 2300.068 -1.8 102786.8IPI:IPI00 2 3 8.10% 198 21482 4.4 U Tax_Id=10090 Gene_Symbol=Sdc4 Syndecan-4 * FOXO_KO.1 4.6632 0.4517 100 1837.961 1836.959 -0.6 96391.3* FOXO_KO.1 3.1928 0.2565 99.7 1836.958 1836.959 -0.5 204370.7IPI:IPI00 2 18 8.10% 160 18442 10.1 U Tax_Id=10090 Gene_Symbol=LOC100046435 similar to ribosomal protein L6

FOXO_KO.9 4.2966 0.4251 100 1334.611 1332.607 -1.6 546699.8FOXO_KO.7 4.1025 0.4404 100 1589.742 1589.744 -1.7 234189.7

IPI:IPI00 1 1 8.10% 148 16659 11.3 U Tax_Id=10090 Gene_Symbol=Gm5453 similar to ribosomal protein L27A IPI:IPI005 1 1 8.10% 148 16589 11.1 U Tax_Id=10090 Gene_Symbol=Rpl27a 60S ribosomal protein L27a

FOXO_KO.1 3.7433 0.4196 100 1422.667 1422.668 -0.7 1229798IPI:IPI00 1 1 8.10% 136 16090 8.4 U Tax_Id=10090 Gene_Symbol=Spna2 Spectrin alpha 2

FOXO_KO.9 2.6284 0.3423 99.9 1302.653 1302.654 -0.8 1103516IPI:IPI001 1 1 8.10% 135 14928 9.9 U Tax_Id=10090 Gene_Symbol=Gm7426 Putative histone H3-like IPI:IPI00 1 1 8.10% 135 15199 11.4 U Tax_Id=10090 Gene_Symbol=- 15 kDa protein IPI:IPI00 1 1 8.10% 136 15242 11.5 U Tax_Id=10090 Gene_Symbol=Gm12657 predicted gene 12657 IPI:IPI00 1 1 8.10% 136 15404 11.1 U Tax_Id=10090 Gene_Symbol=Hist1h3a;Hist1h3i;Hist1h3h;Hist1h3g Histone H3.1 IPI:IPI002 1 1 8.10% 136 15429 11 U Tax_Id=10090 Gene_Symbol=Gm12260 similar to histone H3

FOXO_KO.1 3.2285 0.3275 99.9 1336.694 1335.69 0.4 280263.7IPI:IPI00 12 24 8.00% 640 66709 8.1 U Tax_Id=10090 Gene_Symbol=Foxo6 Foxo6 protein IPI:IPI00 12 24 9.10% 559 57595 6.4 U Tax_Id=10090 Gene_Symbol=Foxo6 Forkhead box protein O6

FOXO_KO.2 5.7754 0.4884 100 1722.9 1721.897 -0.5 175220FOXO_KO.2 4.379 0.4616 100 1803.87 1801.863 -0.1 235785.1FOXO_KO.2 4.2667 0.4576 100 1565.796 1565.796 0.4 141601.3FOXO_KO.3 4.127 0.3501 100 1646.767 1645.762 0.6 274076.3FOXO_KO.1 3.0161 0.3618 100 1251.558 1251.56 -1.6 87628.9FOXO_KO.1 3.8266 0.3195 100 1251.558 1251.56 -1.6 2042793FOXO_KO_w 5.1297 0.3394 100 1721.82 1721.82 -0.4 34864.6FOXO_KO_w 4.1223 0.2673 99.9 1801.79 1801.786 2.2 17309.1FOXO_KO.2 5.7697 0.4974 100 2205.038 2205.039 -0.8 51281.9FOXO_KO.2 2.4459 0.393 100 1391.639 1391.641 -1.5 36196.2FOXO_KO.2 3.033 0.4257 100 1391.644 1391.641 2 218721.7FOXO_KO.3 2.6589 0.2916 99.8 1471.605 1471.608 -1.6 376224.7

IPI:IPI00 3 5 8.00% 449 49280 6.3 U Tax_Id=10090 Gene_Symbol=Hnrnph2 Heterogeneous nuclear ribonucleoprotein H2 IPI:IPI00 3 5 7.60% 472 51218 6.8 U Tax_Id=10090 Gene_Symbol=Hnrnph1 Putative uncharacterized protein IPI:IPI00 3 5 8.00% 449 49199 6.3 U Tax_Id=10090 Gene_Symbol=Hnrnph1 Heterogeneous nuclear ribonucleoprotein H


IPI:IPI00 3 5 8.00% 415 47795 5.5 U Tax_Id=10090 Gene_Symbol=Mrps27 28S ribosomal protein S27, mitochondrial * FOXO_KO.2 3.4825 0.449 100 1891.908 1891.911 -1.3 125859.1* FOXO_KO.1 5.9658 0.4561 100 1995.934 1994.938 -3.3 121275.7* FOXO_KO.1 4.0116 0.3295 99.9 1995.938 1994.938 -1.7 195257.8IPI:IPI00 2 2 8.00% 287 31293 8 U Tax_Id=10090 Gene_Symbol=Lsm14a LSM14 homolog A

FOXO_KO.2 4.7137 0.3514 100 2174.962 2174.962 -0.2 98895.5FOXO_KO.2 4.8516 0.437 100 2831.269 2830.27 -1.7 79479.5

IPI:IPI00 1 1 8.00% 238 26161 5.3 U Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 1 contamina 1 1 8.70% 218 23846 6.7 U owl|S68241| immunoglobulin light chain (Mab13-1) - mouse (fragment) contamina 1 1 8.90% 214 23527 6.5 U owl|| Immunoglobulin igg1-kappa antibody fragment fab complexed With... IPI:IPI00 1 1 8.70% 219 23945 7 U Tax_Id=10090 Gene_Symbol=Igk-C Kappa light chain C_region (Fragment) IPI:IPI00 1 1 8.70% 219 24165 7.4 U Tax_Id=10090 Gene_Symbol=Igk-C If kappa light chain (Fragment) IPI:IPI00 1 1 7.90% 240 26398 5.1 U Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 3 IPI:IPI00 1 1 7.90% 240 26609 6.3 U Tax_Id=10090 Gene_Symbol=Gm10883 ENSMUSG00000076577 protein IPI:IPI00 1 1 8.10% 235 25835 8 U Tax_Id=10090 Gene_Symbol=Gm1499 Putative uncharacterized protein IPI:IPI00 1 1 8.00% 237 26044 7.4 U Tax_Id=10090 Gene_Symbol=Gm10880 LOC100046793 protein IPI:IPI00 1 1 7.90% 239 26302 7.4 U Tax_Id=10090 Gene_Symbol=Igk-C Igk protein IPI:IPI00 1 1 7.90% 242 26574 5.4 U Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 2 IPI:IPI004 1 1 8.00% 238 26317 5.6 U Tax_Id=10090 Gene_Symbol=Igk Igk protein IPI:IPI00 1 1 8.10% 236 26455 7.1 U Tax_Id=10090 Gene_Symbol=Igk Anti-colorectal carcinoma light chain

FOXO_KO.2 4.5109 0.4708 100 2227.005 2227.007 -1 137871.7IPI:IPI00 1 1 8.00% 226 24978 8.6 U Tax_Id=10090 Gene_Symbol=Spcs2 Signal peptidase complex subunit 2 * FOXO_KO.3 4.6634 0.375 100 2004.922 2004.922 0.1 73028.9IPI:IPI00 1 5 8.00% 137 15733 12 U Tax_Id=10090 Gene_Symbol=Rpl28;Gm15435 60S ribosomal protein L28 IPI:IPI006 1 5 8.00% 137 15680 11.9 U Tax_Id=10090 Gene_Symbol=Gm12938 similar to ribosomal protein L28 IPI:IPI00 1 5 8.00% 137 15750 11.9 U Tax_Id=10090 Gene_Symbol=Gm10051 similar to ribosomal protein L28

FOXO_KO_w 3.3412 0.4134 100 1294.625 1294.627 -1.5 86117.8IPI:IPI00 1 1 8.00% 125 14407 10.5 U Tax_Id=10090 Gene_Symbol=Gm5437 hypothetical protein IPI:IPI00 1 1 8.00% 125 14323 10.1 U Tax_Id=10090 Gene_Symbol=Gm6635 hypothetical protein IPI:IPI00 1 1 8.00% 125 14548 10.4 U Tax_Id=10090 Gene_Symbol=- 15 kDa protein IPI:IPI00 1 1 8.00% 125 14462 10.5 U Tax_Id=10090 Gene_Symbol=Gm10072 hypothetical protein IPI:IPI00 1 1 8.00% 125 14479 10.2 U Tax_Id=10090 Gene_Symbol=Gm16382 hypothetical protein

FOXO_KO.9 2.6796 0.4224 100 1145.542 1145.543 -1.3 72184.1IPI:IPI003 6 6 7.90% 1447 162821 5.4 U Tax_Id=10090 Gene_Symbol=Golga3 Isoform 1 of Golgin subfamily A member 3 IPI:IPI004 6 6 7.70% 1487 167219 5.4 U Tax_Id=10090 Gene_Symbol=Golga3 Isoform 2 of Golgin subfamily A member 3

FOXO_KO.1 7.3649 0.5761 100 1886.891 1885.889 -0.4 135641.3FOXO_KO.1 5.2829 0.4592 100 2393.127 2392.124 0.1 148077FOXO_KO.1 4.681 0.1361 99.8 1901.897 1901.899 -1.2 70930.9FOXO_KO.2 5.8099 0.4785 100 2018.004 2018.004 0.2 69889.9FOXO_KO.2 5.3373 0.4883 100 3122.439 3121.445 -3 77225.2FOXO_KO.2 4.9683 0.4688 100 2008.937 2008.938 -0.6 123349.8

IPI:IPI00 7 12 7.90% 902 98709 5.9 U Tax_Id=10090 Gene_Symbol=Aldh1l1 10-formyltetrahydrofolate dehydrogenase

* FOXO_KO.2 4.1866 0.3497 100 1897.867 1896.864 -0.4 173131.4* FOXO_KO.3 5.8505 0.5158 100 2135.048 2134.051 -3.2 38355.7* FOXO_KO.3 3.7173 0.3788 100 1850.924 1849.922 -0.7 117290.6* FOXO_KO.1 4.2408 0.3915 100 2125.023 2125.023 0.2 57804.4* FOXO_KO.1 3.4755 0.2413 99.6 2126.026 2125.023 -0.2 164111.6* FOXO_KO.1 4.5118 0.4052 100 1997.929 1996.928 -1.2 275194.3* FOXO_KO.1 5.2696 0.3517 100 1728.746 1727.743 0 154156.9IPI:IPI00 2 3 7.90% 700 79872 5 U Tax_Id=10090 Gene_Symbol=Capn2 Calpain-2 catalytic subunit * FOXO_KO.2 5.3616 0.3602 100 2811.267 2810.267 -1.1 116175.3

FOXO_KO.3 4.6305 0.4343 100 3599.616 3597.61 -0.3 76424.4IPI:IPI00 2 3 7.90% 598 67474 9.6 U Tax_Id=10090 Gene_Symbol=Ddx52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 * FOXO_KO.4 3.3166 0.3345 99.9 3060.501 3058.489 1.8 60780.5

FOXO_KO.3 5.4363 0.5089 100 2139.084 2137.066 5.3 79781.7IPI:IPI00 2 2 7.90% 519 56538 7.6 U Tax_Id=10090 Gene_Symbol=Aldh2 Aldehyde dehydrogenase, mitochondrial * FOXO_KO.2 5.8859 0.4535 100 2964.429 2962.446 -8.3 116973* FOXO_KO.2 5.4781 0.5022 100 1776.837 1774.828 1.2 317158.4IPI:IPI00 2 2 7.90% 506 55421 8.8 U Tax_Id=10090 Gene_Symbol=Scyl2 Isoform 2 of SCY1-like protein 2

FOXO_KO.1 4.5152 0.4322 100 1639.746 1639.748 -1.1 176003.8FOXO_KO.2 4.2956 0.4489 100 2667.223 2667.231 -3 58982.3

IPI:IPI00 4 21 7.90% 355 40562 10.2 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 2 FOXO_KO.2 5.4225 0.5099 100 1763.922 1761.917 -0.8 418329.8FOXO_KO.2 3.5993 0.3585 99.9 1761.915 1761.917 -1.4 549226.4FOXO_KO_w 2.8484 0.3534 100 1342.574 1342.576 -1 10932.4FOXO_KO_w 4.0559 0.4968 100 1342.575 1342.576 -0.9 293345.8

IPI:IPI002 1 1 7.90% 266 30145 8.2 U Tax_Id=10090 Gene_Symbol=Kctd2 BTB/POZ domain-containing protein KCTD2 IPI:IPI00 1 1 8.00% 263 28578 5.3 U Tax_Id=10090 Gene_Symbol=Kctd2 potassium channel tetramerisation domain containing 2 IPI:IPI00 1 1 8.00% 263 29660 6 U Tax_Id=10090 Gene_Symbol=LOC100046153 similar to KIAA0176 IPI:IPI00 1 1 7.40% 282 30624 5.2 U Tax_Id=10090 Gene_Symbol=Kctd2 Potassium channel tetramerisation domain containing 2 IPI:IPI00 1 1 6.20% 338 36163 5.9 U Tax_Id=10090 Gene_Symbol=Kctd2 Potassium channel tetramerisation domain containing 2

FOXO_KO.3 6.1133 0.5431 100 2500.127 2499.12 1.4 29153.9IPI:IPI00 1 4 7.90% 216 24275 7.9 U Tax_Id=10090 Gene_Symbol=Gstz1 Maleylacetoacetate isomerase IPI:IPI00 1 4 7.90% 215 24205 7.2 U Tax_Id=10090 Gene_Symbol=Gstz1 Brain cDNA, clone MNCb-6148, similar to Mus musculus glutathione transferase zeta 1 (maleylacetoacetate isomerase) (Gstz1), mRNA

FOXO_KO.2 5.0152 0.3949 100 1969.895 1969.896 -0.6 73437.1IPI:IPI00 1 1 7.90% 178 19825 8.6 U Tax_Id=10090 Gene_Symbol=Prdx6 Putative uncharacterized protein IPI:IPI00 1 1 6.20% 224 24827 6.4 U Tax_Id=10090 Gene_Symbol=Prdx6 Putative uncharacterized protein IPI:IPI00 1 1 7.00% 200 22494 8.9 U Tax_Id=10090 Gene_Symbol=Prdx6 22 kDa protein IPI:IPI00 1 1 6.20% 224 24871 6 U Tax_Id=10090 Gene_Symbol=Prdx6 Peroxiredoxin-6

FOXO_KO.4 3.7825 0.4458 100 1526.852 1526.85 1.4 149346.4IPI:IPI00 1 5 7.90% 165 18522 8 U Tax_Id=10090 Gene_Symbol=Dstn Destrin * FOXO_KO_w 5.042 0.4727 100 1543.7 1542.693 2.5 74335.4IPI:IPI00 2 2 7.80% 668 75292 8.1 U Tax_Id=10090 Gene_Symbol=Ablim1 Putative uncharacterized protein IPI:IPI00 2 2 12.20% 426 48601 8.4 U Tax_Id=10090 Gene_Symbol=Ablim1 49 kDa protein IPI:IPI00 2 2 11.50% 454 51771 9 U Tax_Id=10090 Gene_Symbol=Ablim1 52 kDa protein IPI:IPI00 2 2 7.00% 744 83742 8.2 U Tax_Id=10090 Gene_Symbol=Ablim1 84 kDa protein IPI:IPI00 2 2 13.00% 400 45884 8.1 U Tax_Id=10090 Gene_Symbol=Ablim1 Ablim1 protein IPI:IPI00 2 2 6.70% 777 87256 8.3 U Tax_Id=10090 Gene_Symbol=Ablim1 87 kDa protein IPI:IPI00 2 2 7.60% 682 77222 8.5 U Tax_Id=10090 Gene_Symbol=Ablim1 77 kDa protein IPI:IPI00 2 2 7.30% 714 80385 8.1 U Tax_Id=10090 Gene_Symbol=Ablim1 80 kDa protein

IPI:IPI00 2 2 9.50% 545 62004 9.4 U Tax_Id=10090 Gene_Symbol=Ablim1 Isoform 3 of Actin-binding LIM protein 1 IPI:IPI00 2 2 6.00% 861 96805 8.6 U Tax_Id=10090 Gene_Symbol=Ablim1 Isoform 1 of Actin-binding LIM protein 1 IPI:IPI00 2 2 7.40% 701 78960 8.3 U Tax_Id=10090 Gene_Symbol=Ablim1 Isoform 2 of Actin-binding LIM protein 1 IPI:IPI00 2 2 7.10% 730 82362 8.4 U Tax_Id=10090 Gene_Symbol=Ablim1 Ablim1 protein

FOXO_KO.2 5.0412 0.3289 99.9 3312.571 3311.574 -1.9 89470.5FOXO_KO.5 5.5721 0.533 100 3089.584 3088.575 1.5 52076.5

contamina 4 7 7.80% 562 59822 8 U no descriptionFOXO_KO.4 7.2782 0.5489 100 2419.256 2418.251 0.5 125973.8FOXO_KO.4 5.169 0.4402 100 2420.264 2418.251 2.7 168871.3FOXO_KO_w 3.5977 0.3299 100 1315.697 1315.696 0.6 55449.6FOXO_KO.1 3.5055 0.2416 99.8 1357.732 1357.732 -0.4 213307.3

IPI:IPI00 2 3 7.80% 541 59624 6 U Tax_Id=10090 Gene_Symbol=Cct5 T-complex protein 1 subunit epsilon IPI:IPI00 2 3 21.10% 199 21526 5 U Tax_Id=10090 Gene_Symbol=Cct5 22 kDa protein

FOXO_KO.6 5.3048 0.4315 100 3114.555 3113.548 1 18466.1FOXO_KO.2 4.6052 0.4061 100 1391.742 1391.742 0.5 95598.8

IPI:IPI00 2 3 7.80% 446 50773 8.1 U Tax_Id=10090 Gene_Symbol=Bckdha branched chain keto acid dehydrogenase E1, alpha polypeptide * FOXO_KO.3 5.8901 0.4511 100 2348.037 2347.037 -1.3 101565.6* FOXO_KO.2 5.1324 0.4071 100 1966.9 1965.898 -0.5 133791.5IPI:IPI00 2 2 7.80% 293 31288 10.2 U Tax_Id=10090 Gene_Symbol=Gm6139 hypothetical protein isoform 1 IPI:IPI00 2 2 7.90% 292 31506 9.9 U Tax_Id=10090 Gene_Symbol=Gm8225 hypothetical protein

FOXO_KO.1 3.8773 0.2957 100 1315.688 1315.689 -0.6 234571.9FOXO_KO.1 3.2075 0.3515 100 1463.715 1463.717 -1.3 210517.6

IPI:IPI00 2 4 7.80% 206 22340 9.7 U Tax_Id=10090 Gene_Symbol=Ywhah Putative uncharacterized protein FOXO_KO.1 5.1642 0.4823 100 1828.82 1828.82 -0.1 134824.6FOXO_KO.1 4.2392 0.4499 100 1829.823 1828.82 -0.6 347394.8

IPI:IPI00 3 4 7.70% 953 106476 6.7 U Tax_Id=10090 Gene_Symbol=Lonp1 Lon protease homolog IPI:IPI00 3 4 7.70% 949 105843 6.6 U Tax_Id=10090 Gene_Symbol=Lonp1 Lon protease homolog, mitochondrial

FOXO_KO.1 4.7913 0.474 100 1696.823 1696.828 -2.7 186292.3FOXO_KO.2 3.4943 0.2361 99.5 2618.26 2617.255 0.7 174261.5FOXO_KO.4 3.9294 0.2618 99.7 3685.84 3684.831 1.5 21152.7

IPI:IPI004 4 4 7.70% 376 42679 5.3 U Tax_Id=10090 Gene_Symbol=Gm5513 similar to eukaryotic initiation factor 4AI isoform 1 FOXO_KO.3 5.1986 0.4433 100 1556.713 1555.713 -2.4 332300.8FOXO_KO.1 4.8724 0.5316 100 1582.668 1581.667 -1.4 248796.6FOXO_KO.1 5.2475 0.4951 100 1868.815 1866.811 -1.6 155545.1FOXO_KO.1 3.6787 0.4374 100 1866.808 1866.811 -1.4 376317.9

IPI:IPI00 1 2 7.70% 325 37290 6.9 U Tax_Id=10090 Gene_Symbol=Akr1d1 3-oxo-5-beta-steroid 4-dehydrogenase * FOXO_KO.3 5.0965 0.3875 100 3019.485 3017.481 -0.9 66890.1IPI:IPI00 2 2 7.70% 274 31026 4.6 U Tax_Id=10090 Gene_Symbol=Por 31 kDa protein

FOXO_KO.4 6.3893 0.5872 100 2455.139 2454.146 -4.1 52355.4FOXO_KO.4 4.6122 0.3569 99.9 2455.15 2454.146 0.3 201826

IPI:IPI00 1 1 7.70% 221 25476 11.9 U Tax_Id=10090 Gene_Symbol=Sfrs2 Splicing factor, arginine/serine-rich 2 IPI:IPI00 1 1 6.70% 254 29001 11.2 U Tax_Id=10090 Gene_Symbol=Sfrs2 Putative uncharacterized protein

FOXO_KO.2 5.0487 0.4568 100 1751.727 1751.721 3.4 108279.4IPI:IPI001 1 2 7.70% 183 20855 5.2 U Tax_Id=10090 Gene_Symbol=Cbx3 Chromobox protein homolog 3 IPI:IPI00 1 2 19.70% 71 8086 9 U Tax_Id=10090 Gene_Symbol=Cbx3 8 kDa protein IPI:IPI006 1 2 7.70% 183 20853 5.6 U Tax_Id=10090 Gene_Symbol=- similar to Chromobox homolog 3 IPI:IPI006 1 2 7.70% 183 20845 5.3 U Tax_Id=10090 Gene_Symbol=LOC633016 similar to Chromobox homolog 3 (HP1 gamma homolog, Drosophila) isoform 2 IPI:IPI006 1 2 7.70% 183 20977 5.4 U Tax_Id=10090 Gene_Symbol=LOC632383 similar to Chromobox homolog 3

IPI:IPI00 1 2 7.70% 182 20627 5.6 U Tax_Id=10090 Gene_Symbol=Gm6901 similar to Chromobox homolog 3 IPI:IPI006 1 2 7.70% 182 20617 5.6 U Tax_Id=10090 Gene_Symbol=Gm5792 similar to Chromobox homolog 3 IPI:IPI003 1 2 7.70% 183 20712 5.4 U Tax_Id=10090 Gene_Symbol=Gm5196 similar to Chromobox homolog 3

FOXO_KO.1 5.2168 0.4346 100 1661.826 1661.827 -0.6 180524.3IPI:IPI003 2 9 7.70% 181 20503 7.5 U Tax_Id=10090 Gene_Symbol=Gm5566 similar to nucleoside diphosphate kinase B

FOXO_KO_w 4.4515 0.2587 99.9 1485.716 1485.718 -1.3 41140.6FOXO_KO_w 3.1136 0.38 99.9 1485.721 1485.718 1.9 49955.6

IPI:IPI006 1 1 7.70% 143 15237 9.3 U Tax_Id=10090 Gene_Symbol=Scp2 Isoform SCP2 of Non-specific lipid-transfer protein FOXO_KO.9 4.1362 0.3403 100 1335.678 1335.679 -1.1 263941.5

IPI:IPI00 1 1 7.60% 289 32667 5.6 U Tax_Id=10090 Gene_Symbol=Ppa1 Inorganic pyrophosphatase * FOXO_KO.2 3.6789 0.3045 99.9 2434.199 2432.194 -0.5 298104.8IPI:IPI00 1 1 7.60% 276 31739 9.4 U Tax_Id=10090 Gene_Symbol=Mtif3 Translation initiation factor IF-3, mitochondrial * FOXO_KO.1 4.6684 0.4706 100 2475.123 2474.125 -2.2 26572IPI:IPI00 1 1 7.60% 249 27855 8.4 U Tax_Id=10090 Gene_Symbol=Vapa Vesicle-associated membrane protein-associated protein A * FOXO_KO.2 5.999 0.5564 100 2297.988 2296.988 -1.5 48910.1IPI:IPI00 2 3 7.60% 210 23537 7.8 U Tax_Id=10090 Gene_Symbol=Gstp2 Glutathione S-transferase P 2 IPI:IPI004 2 3 7.60% 210 23626 8.2 U Tax_Id=10090 Gene_Symbol=Gm3934;LOC100046536 similar to glutathione S-transferase pi class A

FOXO_KO.2 5.2709 0.4857 100 1854.921 1854.923 -1 73481.5FOXO_KO.2 5.3116 0.3368 100 1855.929 1854.923 1.1 158306.3

IPI:IPI008 1 2 7.60% 198 23200 5.3 U Tax_Id=10090 Gene_Symbol=Nedd4 Nedd4 protein FOXO_KO.3 3.9115 0.4111 100 1867.884 1866.88 0.8 74873.5

IPI:IPI00 1 1 7.60% 184 21423 10.2 U Tax_Id=10090 Gene_Symbol=Rpl17 60S ribosomal protein L17 IPI:IPI00 1 1 7.40% 190 21973 9.7 U Tax_Id=10090 Gene_Symbol=Gm6133 EG620155 protein IPI:IPI00 1 1 9.80% 143 16694 9.7 U Tax_Id=10090 Gene_Symbol=LOC100048040 similar to RPL17 protein IPI:IPI008 1 1 8.80% 159 18583 10.1 U Tax_Id=10090 Gene_Symbol=Gm10166 similar to Ac2-210 isoform 2 IPI:IPI00 1 1 7.60% 184 21397 10.2 U Tax_Id=10090 Gene_Symbol=LOC100045527;Rpl17;Gm10223 ribosomal protein L17 IPI:IPI008 1 1 9.20% 153 17733 10.2 U Tax_Id=10090 Gene_Symbol=Gm10166 similar to Ac2-210 isoform 1 IPI:IPI00 1 1 7.60% 184 21363 10.2 U Tax_Id=10090 Gene_Symbol=LOC545379 similar to Rpl17 protein IPI:IPI00 1 1 9.20% 153 17715 10.2 U Tax_Id=10090 Gene_Symbol=LOC100045527 similar to Ac2-210 isoform 2 IPI:IPI00 1 1 8.80% 159 18565 10.1 U Tax_Id=10090 Gene_Symbol=Gm10223 similar to Rpl17 protein isoform 2 IPI:IPI00 1 1 5.40% 259 29159 9.9 U Tax_Id=10090 Gene_Symbol=Gm10362 similar to Rpl17 protein IPI:IPI00 1 1 6.20% 227 26150 10 U Tax_Id=10090 Gene_Symbol=Gm10164 similar to Rpl17 protein IPI:IPI00 1 1 7.60% 184 21279 10.1 U Tax_Id=10090 Gene_Symbol=Gm10268 similar to Rpl17 protein

FOXO_KO.9 3.4378 0.2173 99.8 1623.857 1623.859 -1.1 330195.1IPI:IPI00 3 3 7.50% 533 60285 8 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-2 IPI:IPI00 3 3 7.60% 528 60008 8.4 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-9 IPI:IPI00 3 3 7.50% 530 60116 8.8 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 similar to UDP-glucuronosyltransferase 1A8 IPI:IPI00 3 3 7.50% 535 60047 8.6 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A1 IPI:IPI00 3 3 7.60% 529 60073 8.1 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 IPI:IPI00 3 3 7.50% 531 59758 8.4 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-7C IPI:IPI00 3 3 7.50% 530 60296 8.4 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glycosyltransferase 1 family, polypeptide A10 IPI:IPI00 3 3 7.50% 531 60491 8.7 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A6B IPI:IPI001 3 3 7.50% 535 60124 8.6 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-1 IPI:IPI00 3 3 7.50% 531 60439 8.6 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5;Ugt1a6a UDP-glucuronosyltransferase 1-6

FOXO_KO.4 6.551 0.5794 100 2175.111 2174.101 2.9 163445.1FOXO_KO.5 6.0285 0.5553 100 2349.215 2348.211 0.5 184892.2FOXO_KO.5 4.4868 0.4437 100 2349.216 2348.211 1 413170.3

IPI:IPI00 2 2 7.50% 425 46664 6.9 U Tax_Id=10090 Gene_Symbol=Plin2 Perilipin-2

FOXO_KO.1 3.9712 0.2327 99.9 1263.641 1263.643 -1.4 277906.1FOXO_KO.1 6.2262 0.3857 100 2249.946 2248.941 0.7 50468.6

IPI:IPI00 1 1 7.50% 359 41192 8.6 U Tax_Id=10090 Gene_Symbol=Mrps22 28S ribosomal protein S22, mitochondrial * FOXO_KO.3 4.2588 0.2504 99.8 2982.434 2981.431 -0.2 126686.4IPI:IPI00 2 3 7.50% 307 34958 6.5 U Tax_Id=10090 Gene_Symbol=Tyms Thymidylate synthase * FOXO_KO.1 5.0537 0.4963 100 2618.147 2618.146 0.3 178278.7* FOXO_KO.1 6.0525 0.4776 100 1786.759 1785.76 -2.1 196482.3IPI:IPI00 2 2 7.50% 254 28700 4.3 U Tax_Id=10090 Gene_Symbol=Caprin1 Cell cycle associated protein 1

FOXO_KO.3 6.1369 0.4897 100 2296.143 2295.14 -0.3 51945FOXO_KO.3 4.46 0.3929 100 2296.143 2295.14 -0.3 157363.6

IPI:IPI00 1 2 7.50% 186 21390 7.8 U Tax_Id=10090 Gene_Symbol=Arl8a ADP-ribosylation factor-like protein 8A IPI:IPI00 1 2 8.50% 165 18870 8.2 U Tax_Id=10090 Gene_Symbol=Arl8a Protein

FOXO_KO.2 4.2142 0.4022 100 1543.821 1543.821 -0.1 226879.8IPI:IPI00 1 5 7.50% 133 15220 9.6 U Tax_Id=10090 Gene_Symbol=Actn4 15 kDa protein

FOXO_KO.1 3.2523 0.2534 99.9 1300.674 1299.669 1.1 28397.5IPI:IPI00 4 5 7.40% 999 111181 5.2 U Tax_Id=10090 Gene_Symbol=Hyou1 Hypoxia up-regulated protein 1 * FOXO_KO.3 2.6822 0.2835 99.8 1642.753 1642.742 6.6 103743.7* FOXO_KO.3 6.3262 0.5025 100 2369.127 2368.129 -2.3 85244.8* FOXO_KO.1 4.9082 0.4738 100 2543.192 2542.194 -2.4 30986.4* FOXO_KO.4 4.2383 0.4372 100 2254.104 2253.103 -0.9 139074.4IPI:IPI001 3 3 7.40% 699 77923 7.1 U Tax_Id=10090 Gene_Symbol=Acsl1 Long-chain-fatty-acid--CoA ligase 1 IPI:IPI00 3 3 7.40% 699 78035 7.5 U Tax_Id=10090 Gene_Symbol=Acsl1 78 kDa protein IPI:IPI00 3 3 7.40% 699 77952 7.1 U Tax_Id=10090 Gene_Symbol=Acsl1 acyl-CoA synthetase long-chain family member 1

FOXO_KO.3 6.5545 0.4584 100 2178.082 2176.081 -2.4 239360.2FOXO_KO.2 5.7069 0.4007 100 1717.886 1716.884 -0.8 186454.9FOXO_KO.1 4.7756 0.391 100 1926.954 1926.956 -0.6 303122

IPI:IPI00 3 3 7.40% 625 70622 8.5 U Tax_Id=10090 Gene_Symbol=Srp68 Signal recognition particle 68 kDa protein IPI:IPI00 3 3 7.40% 625 70574 8.6 U Tax_Id=10090 Gene_Symbol=Srp68 Signal recognition particle 68 IPI:IPI00 3 3 7.80% 587 65953 7.3 U Tax_Id=10090 Gene_Symbol=Srp68 Signal recognition particle 68

FOXO_KO.3 3.8092 0.3181 99.9 2647.369 2646.362 1.4 110361.5FOXO_KO.5 5.1712 0.3075 100 2597.43 2596.423 1.3 40577.6FOXO_KO.5 4.1229 0.3004 99.9 2597.425 2596.423 -0.5 76070.8

IPI:IPI001 2 2 7.40% 526 59482 4.9 U Tax_Id=10090 Gene_Symbol=Aatf Isoform 1 of Protein AATF IPI:IPI004 2 2 9.50% 411 47085 8.7 U Tax_Id=10090 Gene_Symbol=Aatf Isoform 2 of Protein AATF

FOXO_KO.1 3.9069 0.2737 99.9 2423.173 2422.173 -1.3 234692.2FOXO_KO.3 3.524 0.3312 99.9 2299.023 2298.02 0.1 149056.1

IPI:IPI00 1 1 7.40% 421 46481 8.4 U Tax_Id=10090 Gene_Symbol=Acadm Medium-chain specific acyl-CoA dehydrogenase, mitochondrial * FOXO_KO.5 4.4313 0.2416 99.8 3308.604 3306.596 0.5 37907.1IPI:IPI00 1 1 7.40% 406 45960 6.9 U Tax_Id=10090 Gene_Symbol=Tmem49 Transmembrane protein 49 * FOXO_KO.3 4.0054 0.3897 99.9 3444.451 3443.449 -0.4 51207.6IPI:IPI00 1 1 7.40% 242 28063 9.9 U Tax_Id=10090 Gene_Symbol=Mrps7 28S ribosomal protein S7, mitochondrial * FOXO_KO.1 4.8305 0.4203 100 2177.135 2177.134 0.7 323717.8IPI:IPI008 1 1 7.40% 258 27015 4.9 U Tax_Id=10090 Gene_Symbol=Hspd1 Isoform 2 of 60 kDa heat shock protein, mitochondrial

FOXO_KO.2 6.1171 0.3609 100 2298.146 2297.139 1.2 133837.8IPI:IPI00 2 3 7.40% 216 24945 9.5 U Tax_Id=10090 Gene_Symbol=Mrpl24 39S ribosomal protein L24, mitochondrial * FOXO_KO.3 3.0377 0.2944 99.8 1851.847 1851.846 0.7 125879.9* FOXO_KO.3 4.2643 0.3563 99.9 1851.846 1851.846 -0.1 118654.7IPI:IPI00 2 2 7.40% 188 21278 10.3 U Tax_Id=10090 Gene_Symbol=Gm7263;LOC676847 similar to Rps15a protein

IPI:IPI00 2 2 20.30% 69 7864 10.3 U Tax_Id=10090 Gene_Symbol=Rps15a 8 kDa protein IPI:IPI00 2 2 13.00% 108 12311 10.2 U Tax_Id=10090 Gene_Symbol=Rps15a 12 kDa protein IPI:IPI00 2 2 19.70% 71 8107 10.4 U Tax_Id=10090 Gene_Symbol=Rps15a 8 kDa protein IPI:IPI00 2 2 10.40% 135 15300 9.1 U Tax_Id=10090 Gene_Symbol=LOC100044556 similar to hCG1994130 IPI:IPI007 2 2 13.20% 106 12148 10.3 U Tax_Id=10090 Gene_Symbol=Gm13253 similar to hCG1994130 IPI:IPI00 2 2 10.80% 130 14839 10.1 U Tax_Id=10090 Gene_Symbol=Rps15a 40S ribosomal protein S15a

FOXO_KO.2 5.0975 0.495 100 1700.804 1700.803 0.7 133191.1FOXO_KO.1 3.8095 0.3064 99.9 1700.804 1700.803 0.4 281856.6

IPI:IPI00 1 1 7.40% 176 20732 10.7 U Tax_Id=10090 Gene_Symbol=Rpl18a 60S ribosomal protein L18a IPI:IPI00 1 1 6.80% 191 22377 10.7 U Tax_Id=10090 Gene_Symbol=Gm15427 ribosomal protein L18A family member IPI:IPI00 1 1 8.60% 151 17485 9.9 U Tax_Id=10090 Gene_Symbol=Rpl18a Rpl18a protein

FOXO_KO.1 2.9828 0.4404 100 1455.688 1455.69 -1.4 133776.1IPI:IPI00 1 1 7.40% 163 19611 10 U Tax_Id=10090 Gene_Symbol=Gm6457;Rsl24d1 Probable ribosome biogenesis protein RLP24 IPI:IPI00 1 1 7.00% 171 20681 11.2 U Tax_Id=10090 Gene_Symbol=Rsl24d1 Putative uncharacterized protein

FOXO_KO.2 3.3151 0.3687 100 1457.677 1457.679 -1.8 172705.9IPI:IPI00 1 2 7.40% 135 16005 10.6 U Tax_Id=10090 Gene_Symbol=Gm4987 MCG49690 IPI:IPI00 1 2 7.40% 135 15860 11.3 U Tax_Id=10090 Gene_Symbol=Rpl32 60S ribosomal protein L32

FOXO_KO.2 3.3403 0.2908 99.9 1248.633 1248.633 0.3 203539.8IPI:IPI00 1 8 7.40% 135 15422 10 U Tax_Id=10090 Gene_Symbol=Mrpl54 39S ribosomal protein L54, mitochondrial * FOXO_KO_w 3.4767 0.2297 99.9 1229.634 1229.637 -2.5 40497.6IPI:IPI00 3 3 7.30% 943 103935 5.2 U Tax_Id=10090 Gene_Symbol=Ap1b1 adaptor protein complex AP-1, beta 1 subunit IPI:IPI00 3 3 7.20% 953 104998 5.1 U Tax_Id=10090 Gene_Symbol=Ap1b1 Putative uncharacterized protein

FOXO_KO.1 2.8485 0.3122 99.9 1229.564 1228.563 -1.6 320461.6FOXO_KO.5 4.75 0.4615 100 2993.571 2992.563 1.7 66765.2FOXO_KO.5 5.7664 0.511 100 3617.832 3615.843 -5 40345.7

IPI:IPI00 5 5 7.30% 769 89361 5.5 U Tax_Id=10090 Gene_Symbol=Cald1 89 kDa protein FOXO_KO.1 3.5139 0.2415 99.8 1637.837 1637.838 -0.8 166003.7FOXO_KO.1 3.5132 0.4224 100 1337.684 1337.684 0.2 210379.4FOXO_KO.9 2.8663 0.3193 99.9 1485.76 1485.766 -3.8 170674.8FOXO_KO.3 4.6917 0.381 100 1643.786 1643.787 -0.7 26534.5FOXO_KO.1 3.5826 0.2088 99.8 1528.823 1528.822 1 206314.9

IPI:IPI00 2 3 7.30% 504 57233 6.6 U Tax_Id=10090 Gene_Symbol=Cyp2d10 Cytochrome P450 2D10 IPI:IPI00 2 3 7.40% 502 56893 6.5 U Tax_Id=10090 Gene_Symbol=Cyp2d10 57 kDa protein

FOXO_KO.6 2.2334 0.3308 99.5 2811.56 2811.558 1 3330.5FOXO_KO.3 4.1966 0.2101 99.9 1363.711 1363.71 0.3 149732.4

IPI:IPI001 3 4 7.30% 490 55513 7.4 U Tax_Id=10090 Gene_Symbol=Cyp2c37 Cytochrome P450 2C37 FOXO_KO.1 4.5717 0.205 99.9 1666.884 1665.881 -0.3 349183.1FOXO_KO.3 6.0988 0.4971 100 2554.208 2553.2 1.5 61882.2FOXO_KO.3 4.6988 0.471 100 2555.21 2553.2 1 267705.8

IPI:IPI00 2 3 7.30% 454 48995 9 U Tax_Id=10090 Gene_Symbol=Dlst Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial * FOXO_KO.2 5.5449 0.4937 100 2249.098 2248.109 -6.5 55162.6

FOXO_KO.1 4.2415 0.4722 100 1455.658 1454.658 -2 311857.5IPI:IPI003 1 1 7.30% 260 27913 5.9 U Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10E of 26S proteasome non-ATPase regulatory subunit 4

FOXO_KO.2 3.7369 0.3438 99.9 2207.091 2206.087 0 171113.4IPI:IPI00 2 2 7.30% 246 27372 6.7 U Tax_Id=10090 Gene_Symbol=Psma6 Proteasome subunit alpha type-6 * FOXO_KO.3 5.9627 0.5467 100 1979.044 1979.044 -0.4 124190.6* FOXO_KO.3 2.7402 0.3356 99.8 1979.045 1979.044 0.1 94333.4IPI:IPI001 1 1 7.30% 218 25827 10.4 U Tax_Id=10090 Gene_Symbol=Mrps34 28S ribosomal protein S34, mitochondrial

* FOXO_KO.1 2.9571 0.2484 99.5 1877.867 1877.867 0.3 533135.1IPI:IPI00 5 6 7.20% 908 100203 5.2 U Tax_Id=10090 Gene_Symbol=Psmd2 26S proteasome non-ATPase regulatory subunit 2 * FOXO_KO.3 5.0577 0.366 99.9 3335.571 3333.564 0.2 81869* FOXO_KO.3 4.1726 0.3514 99.9 3334.566 3333.564 -0.2 183832.6* FOXO_KO.2 3.1291 0.4013 99.9 2070 2067.998 -2.5 154202* FOXO_KO.5 3.1665 0.2437 99.8 2014.085 2014.085 0 44379.9* FOXO_KO.5 3.8293 0.3782 99.9 2014.087 2014.085 0.9 151574.9IPI:IPI002 6 8 7.20% 651 73358 8 U Tax_Id=10090 Gene_Symbol=Fxr1 Isoform G of Fragile X mental retardation syndrome-related protein 1

FOXO_KO.2 7.9356 0.6104 100 2315.072 2314.074 -2 95435.2FOXO_KO.2 3.5969 0.4775 100 2315.078 2314.074 0.3 160825.5FOXO_KO.1 4.7392 0.4774 100 1639.782 1639.781 0.4 170152FOXO_KO.1 3.8776 0.4085 100 1511.684 1511.686 -1.4 200262.4FOXO_KO.5 4.456 0.3264 100 1695.877 1695.874 1.4 96896FOXO_KO.5 3.4301 0.4647 100 1696.879 1695.874 0.8 43149.2

IPI:IPI00 1 1 7.20% 374 42517 5.7 U Tax_Id=10090 Gene_Symbol=Eif3m Eukaryotic translation initiation factor 3 subunit M IPI:IPI00 1 1 11.20% 242 27879 7.2 U Tax_Id=10090 Gene_Symbol=Eif3m Eukaryotic translation initiation factor 3, subunit M

FOXO_KO.5 5.5053 0.4352 100 3041.469 3039.461 0.4 52846.6IPI:IPI00 1 1 7.20% 291 32951 7.1 U Tax_Id=10090 Gene_Symbol=Stard10 PCTP-like protein * FOXO_KO.4 4.0579 0.3858 99.9 2629.145 2628.141 0.2 162622IPI:IPI00 1 1 7.20% 291 32313 9.1 U Tax_Id=10090 Gene_Symbol=Mrps2 28S ribosomal protein S2, mitochondrial * FOXO_KO.1 5.5173 0.4822 100 2173.02 2172.02 -1.7 76866.2IPI:IPI00 4 4 7.20% 222 21675 9.6 U Tax_Id=10090 Gene_Symbol=- 22 kDa protein

FOXO_KO.2 3.7799 0.3821 100 1869.875 1869.877 -0.7 125442.9FOXO_KO.2 4.3631 0.3994 100 1869.874 1869.877 -1.3 298207.1FOXO_KO.2 5.5601 0.4986 100 1713.773 1713.776 -1.8 660872.2FOXO_KO.2 2.8561 0.3168 99.8 1713.774 1713.776 -0.9 248223.5

IPI:IPI00 1 2 7.20% 153 16605 7.5 U Tax_Id=10090 Gene_Symbol=Rbm3 Putative RNA-binding protein 3 * FOXO_KO.3 3.2427 0.2299 99.8 1205.491 1204.487 1.3 53083.8IPI:IPI00 2 4 7.10% 687 77970 5.7 U Tax_Id=10090 Gene_Symbol=Ptcd3 Putative uncharacterized protein * FOXO_KO.4 4.966 0.3026 99.9 3529.641 3527.635 0 87029.8* FOXO_KO.2 4.052 0.2427 99.8 2126.035 2125.038 -3 197994.7IPI:IPI004 3 3 7.10% 589 63616 4.7 U Tax_Id=10090 Gene_Symbol=Rangap1 Ran GTPase-activating protein 1 IPI:IPI00 3 3 7.10% 589 63531 4.7 U Tax_Id=10090 Gene_Symbol=Rangap1 RAN GTPase activating protein 1

FOXO_KO.3 4.6439 0.435 100 2718.385 2718.383 0.6 188041.6FOXO_KO.3 3.5148 0.4014 99.9 1876.98 1875.97 3.5 154414.7FOXO_KO.2 6.4441 0.4445 100 1842.99 1841.986 0.6 149022

contamina 4 5 7.10% 590 62461 8.1 U no description* FOXO_KO.1 3.0486 0.2982 99.9 865.3911 865.3911 0 135568

FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715

* FOXO_KO.4 3.9546 0.3338 99.9 2406.246 2404.235 1.5 152285IPI:IPI00 4 5 7.10% 550 60168 9.2 U Tax_Id=10090 Gene_Symbol=Gm12620 Putative uncharacterized protein (Fragment) IPI:IPI009 4 5 5.90% 660 72425 9 U Tax_Id=10090 Gene_Symbol=Gm12623 similar to Poly A binding protein, cytoplasmic 4 isoform 1

FOXO_KO.1 5.4766 0.3856 100 1713.793 1712.792 -1 101707.2FOXO_KO.1 4.8403 0.4726 100 2155.051 2154.05 -1.3 176626.6FOXO_KO.3 7.0531 0.6044 100 2274.073 2273.072 -0.9 89316FOXO_KO.3 3.3875 0.3812 99.9 2273.074 2273.072 1 136513.5

IPI:IPI00 2 2 7.10% 508 57599 8.3 U Tax_Id=10090 Gene_Symbol=Farsa Phenylalanyl-tRNA synthetase alpha chain

IPI:IPI00 2 2 7.10% 507 57471 8 U Tax_Id=10090 Gene_Symbol=Farsa Farsla protein FOXO_KO.1 3.1709 0.3777 100 1416.736 1416.733 1.9 154434.5FOXO_KO.3 3.9516 0.3837 99.9 2849.393 2847.388 -0.8 86346.2

IPI:IPI00 3 4 7.10% 481 54753 7.1 U Tax_Id=10090 Gene_Symbol=Fgb Fibrinogen beta chain * FOXO_KO.2 6.106 0.4668 100 2053.956 2051.952 -1.1 189902.8* FOXO_KO.3 4.3334 0.3913 100 1691.802 1691.802 0 204783.2* FOXO_KO.3 3.4688 0.3322 99.9 1992.948 1991.945 -0.3 134914.5IPI:IPI00 3 4 7.10% 365 39807 9.4 U Tax_Id=10090 Gene_Symbol=Dnajb6 Isoform A of DnaJ homolog subfamily B member 6 IPI:IPI00 3 4 10.70% 242 26978 7.6 U Tax_Id=10090 Gene_Symbol=Dnajb6 Isoform B of DnaJ homolog subfamily B member 6

FOXO_KO.5 6.9686 0.4455 100 3056.308 3054.301 0.3 84506.1FOXO_KO.5 6.019 0.4819 100 2360.979 2360.977 0.8 82783.5FOXO_KO.4 4.053 0.3198 99.9 2518.085 2517.078 1.2 149713.8

IPI:IPI00 3 5 7.10% 339 39025 11.5 U Tax_Id=10090 Gene_Symbol=Sfrs6 arginine/serine-rich splicing factor 6 * FOXO_KO.2 5.6382 0.5307 100 2741.204 2740.201 0 27838.4* FOXO_KO.2 4.4485 0.4837 100 2740.204 2740.201 1.2 102126* FOXO_KO.1 4.3771 0.4779 100 1340.605 1339.601 0 299733.9IPI:IPI00 1 1 7.10% 283 32132 7.4 U Tax_Id=10090 Gene_Symbol=Mrpl46 39S ribosomal protein L46, mitochondrial * FOXO_KO.4 4.3745 0.2658 99.9 2269.196 2268.19 0.8 80404.8IPI:IPI00 1 1 7.10% 255 26940 11.2 U Tax_Id=10090 Gene_Symbol=Thoc4 Isoform 1 of THO complex subunit 4 IPI:IPI00 1 1 8.30% 218 23785 10.1 U Tax_Id=10090 Gene_Symbol=Refbp2 RNA and export factor binding protein 2 IPI:IPI003 1 1 8.30% 217 23602 10 U Tax_Id=10090 Gene_Symbol=Refbp2 Isoform 2 of RNA and export factor-binding protein 2 IPI:IPI003 1 1 8.30% 218 23730 10 U Tax_Id=10090 Gene_Symbol=Refbp2 Isoform 1 of RNA and export factor-binding protein 2 IPI:IPI001 1 1 11.00% 163 17682 9.7 U Tax_Id=10090 Gene_Symbol=Thoc4 Isoform 2 of THO complex subunit 4

FOXO_KO.2 5.5676 0.5964 100 2034.968 2034.973 -2.5 95705.6IPI:IPI006 1 1 7.10% 156 17957 10.2 U Tax_Id=10090 Gene_Symbol=LOC635326 similar to hCG2028724

FOXO_KO.1 2.8801 0.2496 99.8 1216.631 1216.632 -1.2 437177.4IPI:IPI00 1 1 7.10% 154 15943 6.5 U Tax_Id=10090 Gene_Symbol=Sod1 Superoxide dismutase [Cu-Zn] * FOXO_KO.1 3.2678 0.3026 99.9 1174.566 1174.57 -3 284387.5IPI:IPI00 3 3 7.00% 953 105730 5.4 U Tax_Id=10090 Gene_Symbol=Psmd1 26S proteasome non-ATPase regulatory subunit 1 IPI:IPI00 3 3 6.70% 1002 110872 5.4 U Tax_Id=10090 Gene_Symbol=Psmd1 111 kDa protein

FOXO_KO.5 5.2783 0.3837 100 3387.648 3386.643 0.5 42910.6FOXO_KO.2 5.6979 0.5656 100 2161.981 2161.982 -0.3 90902.8FOXO_KO.2 3.6366 0.2266 99.5 2022.97 2021.966 0.3 242351.6

IPI:IPI00 1 1 7.00% 557 58601 8.4 U Tax_Id=10090 Gene_Symbol=Taf15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor IPI:IPI00 1 1 7.50% 517 54912 8.4 U Tax_Id=10090 Gene_Symbol=Taf15 Putative uncharacterized protein IPI:IPI00 1 1 6.60% 589 62181 8.9 U Tax_Id=10090 Gene_Symbol=Taf15 62 kDa protein

FOXO_KO.3 4.2837 0.4416 100 4208.867 4206.865 -1 13565.4IPI:IPI00 3 4 7.00% 499 55402 5.7 U Tax_Id=10090 Gene_Symbol=Prpf31 Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp31 IPI:IPI007 3 4 7.10% 495 54973 5.9 U Tax_Id=10090 Gene_Symbol=Prpf31 Isoform 3 of U4/U6 small nuclear ribonucleoprotein Prp31

FOXO_KO.1 3.461 0.3621 99.9 1351.692 1350.69 -0.9 443655FOXO_KO.3 5.71 0.5036 100 2673.224 2672.219 0.9 50361.9FOXO_KO.3 4.8559 0.4443 100 2672.215 2672.219 -1.4 183369.3

contamina 2 3 7.00% 429 47927 5.5 U no descriptionFOXO_KO.4 7.5587 0.5408 100 2178.183 2177.177 0.9 164479.5FOXO_KO.2 4.3751 0.3321 100 1420.753 1419.748 1.6 252901.8

IPI:IPI001 2 2 7.00% 371 42436 5.4 U Tax_Id=10090 Gene_Symbol=Prmt1 Isoform 1 of Protein arginine N-methyltransferase 1 IPI:IPI00 2 2 7.30% 354 40759 5.7 U Tax_Id=10090 Gene_Symbol=Prmt1 Prmt1 protein IPI:IPI00 2 2 7.20% 363 41268 5.4 U Tax_Id=10090 Gene_Symbol=Prmt1 41 kDa protein

IPI:IPI002 2 2 7.60% 343 39576 5.7 U Tax_Id=10090 Gene_Symbol=Prmt1 Isoform 3 of Protein arginine N-methyltransferase 1 IPI:IPI002 2 2 7.40% 353 40522 5.6 U Tax_Id=10090 Gene_Symbol=Prmt1 Isoform 2 of Protein arginine N-methyltransferase 1

FOXO_KO.1 3.9555 0.4197 100 1355.741 1355.742 -0.7 196461FOXO_KO.2 4.2324 0.2125 99.9 1643.861 1642.859 -0.8 277352.4

IPI:IPI003 2 2 7.00% 286 32940 5.6 U Tax_Id=10090 Gene_Symbol=Capza1 F-actin-capping protein subunit alpha-1 IPI:IPI00 2 2 7.00% 286 32954 5.6 U Tax_Id=10090 Gene_Symbol=Capza1 F-actin capping protein alpha-1 subunit IPI:IPI008 2 2 7.00% 286 32910 5.6 U Tax_Id=10090 Gene_Symbol=Gm3608 similar to Capping protein (actin filament) muscle Z-line, alpha 1 IPI:IPI00 2 2 6.90% 290 33294 6.7 U Tax_Id=10090 Gene_Symbol=Capza1 Putative uncharacterized protein

FOXO_KO.1 5.9711 0.4853 100 2232.059 2231.057 -0.7 81311.1FOXO_KO.1 3.5565 0.2433 99.6 2233.062 2231.057 -1 217362.1

IPI:IPI00 2 2 7.00% 270 31420 10.9 U Tax_Id=10090 Gene_Symbol=Rpl7 60S ribosomal protein L7 IPI:IPI00 2 2 7.00% 270 31390 10.9 U Tax_Id=10090 Gene_Symbol=Rpl7 Putative uncharacterized protein IPI:IPI00 2 2 7.00% 270 31109 10.5 U Tax_Id=10090 Gene_Symbol=Gm5045 similar to 60S ribosomal protein L7 isoform 2

FOXO_KO.8 5.5093 0.2877 100 2115.975 2115.98 -2.3 233872.5FOXO_KO.8 3.8748 0.2128 99.6 2116.979 2115.98 -2 907143.4

IPI:IPI00 1 2 7.00% 199 22395 8.2 U Tax_Id=10090 Gene_Symbol=Tagln2 Transgelin-2 * FOXO_KO.3 3.517 0.4025 100 1594.712 1594.717 -3.1 131493.4IPI:IPI00 9 11 6.90% 1915 217749 5.8 U Tax_Id=10090 Gene_Symbol=Chd4 Chromodomain-helicase-DNA-binding protein 4 IPI:IPI00 9 11 6.90% 1902 216369 5.9 U Tax_Id=10090 Gene_Symbol=Chd4 Putative uncharacterized protein IPI:IPI00 9 11 6.90% 1922 218632 5.9 U Tax_Id=10090 Gene_Symbol=Chd4 MKIAA4075 protein

FOXO_KO.4 4.5655 0.4281 100 2873.249 2871.242 0.3 122885.3FOXO_KO.1 3.4136 0.2936 99.9 1472.657 1470.65 0.6 254773.4FOXO_KO.4 5.1782 0.5453 100 2495.236 2493.23 0.1 156278.6FOXO_KO.4 3.1472 0.2244 99.5 1852.884 1851.883 -1.3 126818.2FOXO_KO.3 4.1496 0.315 99.9 2301.093 2300.09 -0.5 127215.9FOXO_KO.1 2.8215 0.2922 99.5 3505.522 3504.52 -0.3 33497.6FOXO_KO.1 4.9158 0.4083 100 3506.523 3504.52 -0.9 143749.2FOXO_KO.3 4.1673 0.3431 99.9 2976.359 2975.357 -0.6 88078.8FOXO_KO.3 6.824 0.52 100 2480.067 2478.061 -0.3 37783

IPI:IPI00 3 3 6.90% 970 108983 5.5 U Tax_Id=10090 Gene_Symbol=Eif3b Eif3b protein IPI:IPI00 3 3 6.90% 969 108836 5.5 U Tax_Id=10090 Gene_Symbol=Eif3b 109 kDa protein

FOXO_KO.4 3.6939 0.357 99.9 2168.918 2167.912 0.9 53522.1FOXO_KO.2 3.6449 0.362 99.9 2692.339 2690.338 -2 97841.8FOXO_KO.4 5.2946 0.5515 100 2166.045 2165.034 3.4 44897.8

IPI:IPI00 2 2 6.90% 536 60343 8.3 U Tax_Id=10090 Gene_Symbol=Nop58 Nucleolar protein 58 * FOXO_KO.3 6.1239 0.4955 100 2203.054 2202.045 2.5 96474.7* FOXO_KO.1 5.5627 0.552 100 1848.77 1848.771 -0.2 125899.6IPI:IPI00 2 4 6.90% 520 58415 7.1 U Tax_Id=10090 Gene_Symbol=Tor1aip1 Torsin-1A-interacting protein 1 IPI:IPI00 2 4 6.10% 595 66780 7.2 U Tax_Id=10090 Gene_Symbol=Tor1aip1 Lamina-associated polypeptide 1B

FOXO_KO.2 4.8052 0.58 100 1772.783 1771.781 -0.9 137579.9FOXO_KO.2 5.8095 0.4362 100 2347.131 2345.126 -0.5 278232.6

IPI:IPI00 4 23 6.90% 491 56120 8.4 U Tax_Id=10090 Gene_Symbol=LOC100048323 similar to RIKEN cDNA C730004C24 gene isoform 2 IPI:IPI00 4 23 6.90% 491 56065 8.3 U Tax_Id=10090 Gene_Symbol=Cyp2c69 similar to RIKEN cDNA C730004C24 gene isoform 2 IPI:IPI00 4 23 6.90% 491 56136 7.9 U Tax_Id=10090 Gene_Symbol=Cyp2c69 cytochrome P450, family 2, subfamily c, polypeptide 69 IPI:IPI00 4 23 6.90% 491 56191 8 U Tax_Id=10090 Gene_Symbol=LOC100048323 similar to RIKEN cDNA C730004C24 gene isoform 1

FOXO_KO.2 3.2254 0.3837 100 1135.638 1135.636 1.7 236375.4FOXO_KO.3 5.1299 0.2829 100 1666.839 1666.84 -0.1 24365.1FOXO_KO.3 3.9353 0.235 99.9 1667.842 1666.84 -0.5 53614.2

FOXO_KO.3 3.5154 0.2442 99.9 1330.689 1329.684 1.2 247303.6IPI:IPI008 3 5 6.90% 348 39390 5.4 U Tax_Id=10090 Gene_Symbol=Gm4949 similar to glutamine synthetase

FOXO_KO_w 2.7103 0.261 99.8 1002.499 1002.5 -1.2 125998FOXO_KO.2 5.513 0.4575 100 1815.831 1814.827 0.7 227015.5FOXO_KO.2 4.6372 0.4586 100 1928.868 1928.869 -0.8 192367

IPI:IPI00 2 3 6.90% 348 37528 5 U Tax_Id=10090 Gene_Symbol=Tfg Trk-fused IPI:IPI00 2 3 10.90% 220 23866 4.9 U Tax_Id=10090 Gene_Symbol=Tfg Trk-fused gene IPI:IPI00 2 3 11.90% 202 21384 4.3 U Tax_Id=10090 Gene_Symbol=Tfg Trk-fused gene IPI:IPI00 2 3 6.00% 397 43020 5.1 U Tax_Id=10090 Gene_Symbol=Tfg Trk-fused

FOXO_KO.2 6.3049 0.5866 100 2492.143 2491.141 -0.6 79189.5FOXO_KO.2 4.2649 0.2712 99.9 2492.14 2491.141 -1.7 137716.9

IPI:IPI00 3 5 6.90% 303 35039 8.3 U Tax_Id=10090 Gene_Symbol=Uox Uricase * FOXO_KO.1 2.7046 0.414 100 1007.479 1007.479 -0.5 276881.3

FOXO_KO.2 4.3845 0.3524 100 1533.782 1533.781 0.6 224749.4FOXO_KO.3 4.006 0.3977 100 1379.689 1377.68 1.7 354400.8

IPI:IPI001 1 1 6.90% 275 31311 5 U Tax_Id=10090 Gene_Symbol=Polr2c DNA-directed RNA polymerase II subunit RPB3 IPI:IPI00 1 1 6.90% 275 31443 4.9 U Tax_Id=10090 Gene_Symbol=Polr2c polymerase (RNA) II (DNA directed) polypeptide C IPI:IPI00 1 1 5.70% 332 37756 5.3 U Tax_Id=10090 Gene_Symbol=Polr2c Putative uncharacterized protein

FOXO_KO.2 4.2977 0.2708 99.9 2276.074 2275.084 -5.7 30961.9IPI:IPI00 1 2 6.90% 261 28656 4.2 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 8.70% 207 22740 9.8 U Tax_Id=10090 Gene_Symbol=Asph aspartate beta-hydroxylase isoform 2 IPI:IPI00 1 2 2.60% 691 77520 5 U Tax_Id=10090 Gene_Symbol=Asph 78 kDa protein IPI:IPI00 1 2 5.80% 310 33342 4.2 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase, isoform CRA_d IPI:IPI00 1 2 24.70% 73 8013 4.2 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 6.10% 294 31769 4.2 U Tax_Id=10090 Gene_Symbol=Asph Putative uncharacterized protein IPI:IPI00 1 2 11.00% 163 16986 5.1 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 9.10% 197 20725 4.4 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 7.30% 245 25934 10 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 12.10% 149 16367 4.7 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 6.60% 272 30149 4.1 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 2.50% 725 81468 5.1 U Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase IPI:IPI00 1 2 2.40% 741 83042 5.1 U Tax_Id=10090 Gene_Symbol=Asph Aspartyl/asparaginyl beta-hydroxylase IPI:IPI00 1 2 2.70% 658 75128 4.9 U Tax_Id=10090 Gene_Symbol=Asph Aspartly beta-hydroxylase IPI:IPI00 1 2 8.40% 215 23699 4 U Tax_Id=10090 Gene_Symbol=Asph Cardiac junctate 3 IPI:IPI00 1 2 8.50% 212 23566 9.7 U Tax_Id=10090 Gene_Symbol=Asph Putative uncharacterized protein IPI:IPI00 1 2 8.50% 212 22489 4.5 U Tax_Id=10090 Gene_Symbol=Asph Asph protein

FOXO_KO.1 6.8299 0.5664 100 1887.799 1886.793 1.7 103159.6IPI:IPI00 1 2 6.90% 248 28112 5.5 U Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein (Fragment) IPI:IPI00 1 2 6.40% 266 29905 7.1 U Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein IPI:IPI00 1 2 7.90% 215 24361 8.3 U Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein IPI:IPI00 1 2 7.60% 225 25323 6.6 U Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein IPI:IPI006 1 2 7.10% 240 27137 5.5 U Tax_Id=10090 Gene_Symbol=Spin1;LOC100046080 Isoform 2 of Spindlin-1 IPI:IPI00 1 2 6.50% 262 29643 7 U Tax_Id=10090 Gene_Symbol=Spin1;LOC100046080 Isoform 1 of Spindlin-1

FOXO_KO.1 7.1541 0.4732 100 2067.9 2065.892 0.8 74654.6IPI:IPI00 1 1 6.90% 204 24146 11.6 U Tax_Id=10090 Gene_Symbol=Rpl15 60S ribosomal protein L15 IPI:IPI00 1 1 6.90% 204 24127 11.6 U Tax_Id=10090 Gene_Symbol=Gm4294 similar to ribosomal protein L15 IPI:IPI00 1 1 6.90% 204 24158 11.6 U Tax_Id=10090 Gene_Symbol=Gm4581 similar to ribosomal protein L15 IPI:IPI00 1 1 6.90% 204 24162 11.5 U Tax_Id=10090 Gene_Symbol=- 24 kDa protein

IPI:IPI006 1 1 7.00% 201 23823 11.5 U Tax_Id=10090 Gene_Symbol=LOC634785 similar to ribosomal protein L15 IPI:IPI004 1 1 6.90% 204 24077 11.6 U Tax_Id=10090 Gene_Symbol=Gm10020 similar to ribosomal protein L15 isoform 1 IPI:IPI004 1 1 5.80% 240 28335 11 U Tax_Id=10090 Gene_Symbol=Gm8420 similar to ribosomal protein L15 IPI:IPI00 1 1 7.30% 193 22792 11 U Tax_Id=10090 Gene_Symbol=Gm5292 similar to ribosomal protein L15

FOXO_KO.1 4.2943 0.4933 100 1660.78 1660.785 -2.9 261284.8IPI:IPI00 1 1 6.90% 188 21645 11.8 U Tax_Id=10090 Gene_Symbol=Rpl18 60S ribosomal protein L18 * FOXO_KO.1 4.5826 0.3754 100 1332.719 1331.717 -1.1 1135575IPI:IPI00 3 4 6.80% 981 112325 5.2 U Tax_Id=10090 Gene_Symbol=Usp15 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 15

FOXO_KO.4 4.7857 0.2798 100 2299.172 2298.165 1.6 74908.2* FOXO_KO.1 4.0277 0.3227 100 1853.885 1852.884 -1.3 104023.8

FOXO_KO.4 4.3481 0.4299 100 3552.69 3552.685 1.2 108123.9IPI:IPI00 2 2 6.80% 591 67278 4.6 U Tax_Id=10090 Gene_Symbol=Canx Calnexin * FOXO_KO.4 4.8571 0.541 100 2953.238 2953.234 1.2 115105.6* FOXO_KO.1 4.0307 0.2584 99.9 1758.798 1757.805 -5.7 152137IPI:IPI00 3 4 6.80% 548 63989 6 U Tax_Id=10090 Gene_Symbol=Eif3d Eukaryotic translation initiation factor 3 subunit D

FOXO_KO.2 5.1051 0.3214 99.9 2012.916 2011.914 -0.8 127425.8* FOXO_KO.2 6.065 0.4772 100 2582.114 2581.111 -0.2 47367.6* FOXO_KO.2 3.9317 0.2354 99.7 2582.113 2581.111 -0.6 62993.3IPI:IPI00 1 2 6.80% 482 55048 5.4 U Tax_Id=10090 Gene_Symbol=- 55 kDa protein

FOXO_KO.2 4.7077 0.4216 100 3727.594 3725.598 -3 32301IPI:IPI00 1 1 6.80% 439 49739 6.8 U Tax_Id=10090 Gene_Symbol=Ankfy1 Isoform 2 of Ankyrin repeat and FYVE domain-containing protein 1

FOXO_KO.4 3.3132 0.3564 99.9 3211.507 3211.507 -0.1 61234.9IPI:IPI00 1 2 6.80% 309 35575 5.4 U Tax_Id=10090 Gene_Symbol=Ppp2cb Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform IPI:IPI00 1 2 6.80% 309 35608 5.5 U Tax_Id=10090 Gene_Symbol=Ppp2ca Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

FOXO_KO.2 5.3217 0.2917 99.9 2511.117 2509.112 -1 267591.7IPI:IPI00 5 25 6.80% 296 33510 10.7 U Tax_Id=10090 Gene_Symbol=Rpl6 60S ribosomal protein L6 IPI:IPI006 5 25 6.80% 296 33482 10.6 U Tax_Id=10090 Gene_Symbol=Gm6136 similar to ribosomal protein L6 IPI:IPI004 5 25 6.50% 309 34894 10.7 U Tax_Id=10090 Gene_Symbol=Gm5428 similar to ribosomal protein L6

FOXO_KO.9 4.2966 0.4251 100 1334.611 1332.607 -1.6 546699.8FOXO_KO.7 4.1025 0.4404 100 1589.742 1589.744 -1.7 234189.7FOXO_KO.1 7.0087 0.5071 100 2510.183 2509.184 -1.6 38419.4FOXO_KO.1 5.9679 0.561 100 2509.18 2509.184 -1.8 229975FOXO_KO.1 4.3077 0.3268 99.9 2511.188 2509.184 -1.1 539750.3

IPI:IPI001 1 1 6.80% 222 25737 8.3 U Tax_Id=10090 Gene_Symbol=Dnajb9 DnaJ homolog subfamily B member 9 IPI:IPI00 1 1 6.80% 222 25616 8.3 U Tax_Id=10090 Gene_Symbol=Dnajb9 Dnajb9 protein

FOXO_KO.1 6.0642 0.5546 100 1669.773 1668.771 -1 287215IPI:IPI00 2 5 6.70% 328 35329 7.6 U Tax_Id=10090 Gene_Symbol=Grhpr Glyoxylate reductase/hydroxypyruvate reductase IPI:IPI00 2 5 11.20% 197 21262 7.8 U Tax_Id=10090 Gene_Symbol=Grhpr 21 kDa protein

FOXO_KO.2 5.4223 0.4154 100 2457.118 2456.115 -0.1 24607.3FOXO_KO.2 5.4079 0.3681 100 2457.115 2456.115 -1.2 157950.6

IPI:IPI006 1 1 6.70% 284 31404 5.1 U Tax_Id=10090 Gene_Symbol=Gm5611 similar to Nucleophosmin 1 isoform 1 FOXO_KO.2 6.3012 0.4 100 2145.014 2145.017 -1.5 219432.7

IPI:IPI002 3 3 6.60% 930 103317 8 U Tax_Id=10090 Gene_Symbol=Scyl2 Isoform 1 of SCY1-like protein 2 * FOXO_KO.5 5.0571 0.4702 100 2493.256 2492.25 1.1 51147.1

FOXO_KO.1 4.5152 0.4322 100 1639.746 1639.748 -1.1 176003.8FOXO_KO.2 4.2956 0.4489 100 2667.223 2667.231 -3 58982.3

IPI:IPI00 3 4 6.60% 814 91698 5.7 U Tax_Id=10090 Gene_Symbol=Hsph1 Isoform HSP105-beta of Heat shock protein 105 kDa FOXO_KO.2 3.5232 0.5204 100 1479.707 1479.707 -0.6 232169.2

FOXO_KO.2 3.6732 0.3739 99.9 2499.21 2497.203 0.1 245885.7FOXO_KO.2 6.0142 0.5729 100 2168.988 2168.987 0.5 105636.9

contamina 2 2 6.60% 458 49644 4.9 U no descriptionFOXO_KO.1 4.3926 0.3543 100 1301.656 1301.658 -2 249696.4

* FOXO_KO.3 5.1014 0.4159 100 2158.015 2157.009 1.4 74082.1IPI:IPI00 1 2 6.60% 346 38356 4.7 U Tax_Id=10090 Gene_Symbol=Pwp1 Putative uncharacterized protein

FOXO_KO.2 4.5882 0.3109 99.9 2793.325 2792.32 0.7 96027.8IPI:IPI00 1 2 6.60% 305 34718 5 U Tax_Id=10090 Gene_Symbol=Nedd4 Neural cell expressed, developmentally down-regulted gene 4, isoform CRA_c

FOXO_KO.3 5.5417 0.3617 100 2287.151 2285.145 -0.2 125187.6IPI:IPI00 1 1 6.60% 305 30530 9.3 U Tax_Id=10090 Gene_Symbol=Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 * FOXO_KO.2 6.6294 0.4997 100 2148.02 2148.024 -1.9 165997.3IPI:IPI00 1 2 6.60% 256 29295 6.5 U Tax_Id=10090 Gene_Symbol=Sf3b1 Putative uncharacterized protein

FOXO_KO.4 3.4312 0.4208 100 1998 1997.989 5.6 51047.1IPI:IPI00 1 1 6.60% 196 20697 5.3 U Tax_Id=10090 Gene_Symbol=Plin2 Adipose differentiation related protein

FOXO_KO.1 3.9712 0.2327 99.9 1263.641 1263.643 -1.4 277906.1IPI:IPI00 1 1 6.60% 167 18314 7.9 U Tax_Id=10090 Gene_Symbol=Ppia Peptidyl-prolyl cis-trans isomerase * FOXO_KO.2 2.9845 0.3349 99.9 1278.581 1278.582 -0.5 199794.4IPI:IPI006 1 1 6.60% 136 16013 10.6 U Tax_Id=10090 Gene_Symbol=Gm6301 hypothetical protein isoform 1 IPI:IPI00 1 1 9.50% 95 11332 10.5 U Tax_Id=10090 Gene_Symbol=Rpl27 60S ribosomal protein L27

FOXO_KO.1 2.4157 0.4789 100 1049.552 1049.551 0.3 462737IPI:IPI00 4 5 6.50% 773 88252 8.6 U Tax_Id=10090 Gene_Symbol=Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform * FOXO_KO.2 5.5627 0.386 100 2515.17 2514.167 0 35094.6* FOXO_KO.2 4.7036 0.369 99.9 2515.17 2514.167 0.2 120103.2* FOXO_KO.2 3.5131 0.4488 100 3168.426 3167.433 -3.2 9393* FOXO_KO.2 4.748 0.3365 99.9 3169.43 3167.433 -2.8 86601.9IPI:IPI00 2 3 6.50% 773 87177 9.6 U Tax_Id=10090 Gene_Symbol=Tceb3 Transcription elongation factor B polypeptide 3 IPI:IPI00 2 3 6.50% 773 87161 9.6 U Tax_Id=10090 Gene_Symbol=Tceb3 Transcription elongation factor B (SIII), polypeptide 3

FOXO_KO.1 5.5636 0.472 100 2710.26 2708.255 -0.7 151225.4FOXO_KO.3 4.7387 0.4539 100 3258.382 3256.39 -4.4 98603.3

IPI:IPI00 2 2 6.50% 323 37046 7.2 U Tax_Id=10090 Gene_Symbol=Akr1c19 aldo-keto reductase family 1, member C19 * FOXO_KO.3 4.297 0.3836 99.9 2570.222 2568.217 -0.6 117259.2* FOXO_KO.3 5.1288 0.1379 99.8 1955.911 1954.91 -1.3 134123.4IPI:IPI00 1 1 6.50% 306 35411 9.2 U Tax_Id=10090 Gene_Symbol=Mrpl45 39S ribosomal protein L45, mitochondrial IPI:IPI00 1 1 7.00% 284 32833 9.5 U Tax_Id=10090 Gene_Symbol=Mrpl45 Putative uncharacterized protein (Fragment)

FOXO_KO.3 4.8999 0.5573 100 2430.213 2429.206 1.5 197167IPI:IPI00 1 1 6.50% 306 34099 8.5 U Tax_Id=10090 Gene_Symbol=Srpk2 WW domain binding protein 6 (Fragment) IPI:IPI00 1 1 2.90% 682 76885 4.9 U Tax_Id=10090 Gene_Symbol=Srpk2 serine/arginine-rich protein-specific kinase 2

FOXO_KO.3 3.9508 0.333 99.9 2293.076 2292.07 1.3 115786.9IPI:IPI00 1 1 6.50% 309 32939 4.9 U Tax_Id=10090 Gene_Symbol=- 33 kDa protein IPI:IPI008 1 1 4.90% 407 42147 5.1 U Tax_Id=10090 Gene_Symbol=Gm9774 similar to Adhesion regulating molecule 1 isoform 1 IPI:IPI008 1 1 5.40% 370 38440 5.1 U Tax_Id=10090 Gene_Symbol=Gm9774 similar to Adhesion regulating molecule 1 isoform 2 IPI:IPI00 1 1 4.90% 407 42060 5.1 U Tax_Id=10090 Gene_Symbol=Adrm1 Proteasomal ubiquitin receptor ADRM1 IPI:IPI00 1 1 6.50% 309 32852 4.9 U Tax_Id=10090 Gene_Symbol=Adrm1 Adrm1 protein

FOXO_KO.2 4.4633 0.5306 100 2358.085 2357.096 -6.2 57310.3IPI:IPI00 1 1 6.50% 263 29598 10.2 U Tax_Id=10090 Gene_Symbol=Rps4x 40S ribosomal protein S4, X isoform IPI:IPI00 1 1 6.50% 263 29559 10.1 U Tax_Id=10090 Gene_Symbol=Gm9294 predicted gene 9294

FOXO_KO.3 5.1861 0.5153 100 1886.929 1885.925 0.5 134169.3IPI:IPI00 2 2 6.50% 216 23713 9.6 U Tax_Id=10090 Gene_Symbol=Ppib Peptidyl-prolyl cis-trans isomerase B

* FOXO_KO.1 3.4893 0.3185 99.9 1526.877 1526.879 -1 196588.7* FOXO_KO.1 3.8318 0.3649 99.9 1527.881 1526.879 -0.5 232504.9IPI:IPI00 2 3 6.50% 199 23284 8.5 U Tax_Id=10090 Gene_Symbol=Uox 23 kDa protein

FOXO_KO.2 4.3845 0.3524 100 1533.782 1533.781 0.6 224749.4FOXO_KO.3 4.006 0.3977 100 1379.689 1377.68 1.7 354400.8

IPI:IPI00 3 3 6.40% 831 94860 6.8 U Tax_Id=10090 Gene_Symbol=Cars Isoform 1 of Cysteinyl-tRNA synthetase, cytoplasmic IPI:IPI00 3 3 7.10% 748 85551 6.8 U Tax_Id=10090 Gene_Symbol=Cars Isoform 2 of Cysteinyl-tRNA synthetase, cytoplasmic

FOXO_KO.5 3.5534 0.3522 99.9 3495.747 3495.738 2.8 38112.3FOXO_KO.3 4.1617 0.3168 99.9 2433.201 2432.198 -0.3 235755.9FOXO_KO.1 2.534 0.3241 99.8 1246.594 1246.595 -0.6 151890.6

IPI:IPI00 2 2 6.40% 358 40555 6.3 U Tax_Id=10090 Gene_Symbol=Dnajb11 DnaJ homolog subfamily B member 11 * FOXO_KO.2 5.2152 0.493 100 2517.108 2516.104 0.4 27076.3* FOXO_KO.2 3.1373 0.3811 99.9 2517.106 2516.104 -0.3 215455.9IPI:IPI00 1 1 6.40% 342 37329 9.4 U Tax_Id=10090 Gene_Symbol=Sfxn5 Sideroflexin-5 IPI:IPI00 1 1 7.30% 302 32783 9.4 U Tax_Id=10090 Gene_Symbol=Sfxn5 Putative uncharacterized protein

FOXO_KO.3 6.9359 0.5772 100 2281.093 2280.088 1 104675IPI:IPI00 1 1 6.40% 297 34935 6.8 U Tax_Id=10090 Gene_Symbol=Ttc35 Tetratricopeptide repeat protein 35 * FOXO_KO.3 4.0143 0.3427 100 2170.006 2169.002 0.7 101423.3IPI:IPI00 1 1 6.40% 280 32399 9.5 U Tax_Id=10090 Gene_Symbol=Rrp7a Ribosomal RNA-processing protein 7 homolog A IPI:IPI00 1 1 6.40% 280 32409 8.9 U Tax_Id=10090 Gene_Symbol=Gm3436 hypothetical protein

FOXO_KO.1 3.8842 0.3709 100 2011.02 2011.023 -1.6 96456.9IPI:IPI00 1 1 6.40% 283 31062 7.1 U Tax_Id=10090 Gene_Symbol=Mtap S-methyl-5'-thioadenosine phosphorylase * FOXO_KO.3 5.2675 0.5579 100 1824.972 1824.97 0.9 192203.1IPI:IPI00 13 16 6.30% 2703 294841 12 U Tax_Id=10090 Gene_Symbol=Srrm2 Srrm2 protein

FOXO_KO.2 6.5049 0.3722 100 2674.136 2673.137 -1.6 59702.1FOXO_KO.2 6.1346 0.4616 100 2674.137 2673.137 -1.1 229087.7FOXO_KO.1 6.4949 0.4869 100 2506.259 2505.258 -0.9 48679.2FOXO_KO.1 4.0731 0.2917 99.9 2505.254 2505.258 -1.7 171995.1FOXO_KO.1 5.5424 0.4682 100 2640.138 2638.138 -2.5 181300FOXO_KO.1 5.4483 0.4632 100 2638.137 2638.138 -0.6 136576.3FOXO_KO.1 4.3409 0.4102 100 2719.107 2718.105 -0.4 121891.7FOXO_KO.1 3.7892 0.3699 100 2015.949 2014.948 -1.1 81585.4FOXO_KO.2 3.5827 0.3518 100 1819.879 1818.879 -1.7 113795.2

* FOXO_KO.1 4.6411 0.4586 100 2290.001 2289.001 -1.1 65965FOXO_KO.2 5.1176 0.615 100 2224.989 2224.007 -9.7 74684.1FOXO_KO_w 3.6421 0.2992 99.9 1733.814 1732.813 -1.2 28994.8FOXO_KO.1 3.4088 0.2964 99.9 1612.72 1610.718 -2.6 217837.5

IPI:IPI00 7 8 6.30% 917 105828 10 U Tax_Id=10090 Gene_Symbol=Bclaf1 Isoform 2 of Bcl-2-associated transcription factor 1 IPI:IPI00 7 8 7.80% 748 86036 10.1 U Tax_Id=10090 Gene_Symbol=Bclaf1 Isoform 3 of Bcl-2-associated transcription factor 1 IPI:IPI00 7 8 6.30% 919 106002 10 U Tax_Id=10090 Gene_Symbol=Bclaf1 Isoform 1 of Bcl-2-associated transcription factor 1

FOXO_KO.1 4.5407 0.4167 100 2609.134 2608.132 -0.5 45304.1FOXO_KO.1 4.6586 0.471 100 2609.133 2608.132 -1 118054.3FOXO_KO.2 4.9197 0.2557 99.9 2728.123 2726.125 -3.4 102916.3FOXO_KO.2 4.3728 0.4747 100 2514.004 2513.003 -0.8 45204.6FOXO_KO.2 4.6611 0.31 99.9 2514.003 2513.003 -1 170313.3FOXO_KO.2 4.0437 0.406 100 1666.823 1666.824 -0.7 228161.3FOXO_KO.2 3.369 0.3047 99.9 1666.822 1666.824 -1.4 75690.3

IPI:IPI00 3 5 6.30% 930 103494 5.9 U Tax_Id=10090 Gene_Symbol=Rbm10 Isoform 1 of RNA-binding protein 10

IPI:IPI00 3 5 6.30% 930 103390 5.9 U Tax_Id=10090 Gene_Symbol=Rbm10 103 kDa protein IPI:IPI00 3 5 6.40% 929 103394 5.9 U Tax_Id=10090 Gene_Symbol=Rbm10 Isoform 3 of RNA-binding protein 10

FOXO_KO_w 3.1441 0.301 99.9 1522.706 1522.706 -0.2 112982.3FOXO_KO.2 5.0879 0.2396 99.9 3111.31 3110.311 -1.5 70308.6FOXO_KO.1 5.459 0.2541 100 2360.091 2359.09 -1 74024

IPI:IPI00 2 3 6.30% 878 98010 5.5 U Tax_Id=10090 Gene_Symbol=Copg Putative uncharacterized protein * FOXO_KO.4 3.6017 0.3683 99.9 2644.208 2642.204 -1 80191.8* FOXO_KO.4 5.4939 0.4411 100 3841.667 3839.66 0 24948.5IPI:IPI00 3 4 6.30% 678 77044 5.5 U Tax_Id=10090 Gene_Symbol=Por NADPH--cytochrome P450 reductase IPI:IPI00 3 4 6.60% 649 72931 5.6 U Tax_Id=10090 Gene_Symbol=Por Por protein

FOXO_KO.4 6.3893 0.5872 100 2455.139 2454.146 -4.1 52355.4FOXO_KO.4 4.6122 0.3569 99.9 2455.15 2454.146 0.3 201826FOXO_KO.3 4.6424 0.3898 100 2587.248 2586.247 -1.1 121598.8

IPI:IPI00 2 2 6.30% 648 73089 6.2 U Tax_Id=10090 Gene_Symbol=Srpk1 Serine/threonine-protein kinase SRPK1 * FOXO_KO.1 3.6773 0.4286 100 1819.865 1819.867 -0.9 139393.1* FOXO_KO.5 4.119 0.3205 99.9 2986.419 2984.41 0.9 28655.3IPI:IPI00 2 2 6.30% 511 56333 7.5 U Tax_Id=10090 Gene_Symbol=Flna Protein

FOXO_KO.1 2.6447 0.244 99.6 1172.592 1172.595 -2.3 267286.7FOXO_KO.1 5.68 0.4694 100 2314.095 2313.099 -3.2 130550.3

IPI:IPI00 2 3 6.30% 474 52053 5.2 U Tax_Id=10090 Gene_Symbol=Krt16 Keratin intermediate filament 16a IPI:IPI00 2 3 6.40% 469 51606 5.2 U Tax_Id=10090 Gene_Symbol=Krt16 Keratin, type I cytoskeletal 16

FOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9FOXO_KO.1 5.4099 0.4586 100 2088.97 2087.966 0.1 86286.4

IPI:IPI00 2 8 6.30% 397 44868 7.1 U Tax_Id=10090 Gene_Symbol=Dnaja1 DnaJ homolog subfamily A member 1 IPI:IPI008 2 8 6.30% 397 44882 6.8 U Tax_Id=10090 Gene_Symbol=Gm15542 similar to DnaJ-like protein IPI:IPI00 2 8 9.00% 278 30997 8.4 U Tax_Id=10090 Gene_Symbol=Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 IPI:IPI006 2 8 6.40% 392 44294 7.1 U Tax_Id=10090 Gene_Symbol=Gm7816 similar to DnaJ-like protein

FOXO_KO.3 5.784 0.4083 100 2721.374 2720.378 -2.5 25091.4FOXO_KO.3 4.6154 0.2942 99.9 2721.379 2720.378 -0.8 158985.6

IPI:IPI00 1 2 6.30% 382 41683 7.7 U Tax_Id=10090 Gene_Symbol=Sqstm1 42 kDa protein FOXO_KO.2 5.359 0.4634 100 2612.126 2612.118 2.9 31916.8

IPI:IPI00 1 1 6.30% 350 41215 8.5 U Tax_Id=10090 Gene_Symbol=Csnk2a2 Casein kinase II subunit alpha' * FOXO_KO.2 4.8635 0.4213 100 2772.22 2770.217 -1.3 84710.4IPI:IPI00 1 2 6.30% 350 40079 6.7 U Tax_Id=10090 Gene_Symbol=Twf1 Twinfilin-1 IPI:IPI007 1 2 5.70% 386 44058 7.1 U Tax_Id=10090 Gene_Symbol=Gm4887 similar to Twinfilin, actin-binding protein, homolog 1

FOXO_KO.2 6.3323 0.4878 100 2562.241 2561.241 -1.3 245348.6IPI:IPI00 1 1 6.30% 331 37963 6.8 U Tax_Id=10090 Gene_Symbol=LOC100047957 similar to Casein kinase 2, alpha 1 polypeptide

FOXO_KO.3 3.2843 0.3742 100 2544.246 2544.25 -1.6 30304IPI:IPI00 2 2 6.30% 334 37317 6.7 U Tax_Id=10090 Gene_Symbol=Hsd17b7 3-keto-steroid reductase * FOXO_KO.4 3.3972 0.2428 99.8 2430.16 2430.163 -1.1 30850* FOXO_KO.4 6.0348 0.4563 100 2587.272 2586.264 1.4 74074.3IPI:IPI00 1 1 6.30% 333 36301 6.4 U Tax_Id=10090 Gene_Symbol=Dhdh Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase * FOXO_KO.4 7.003 0.5541 100 2295.216 2294.213 -0.2 89133.6IPI:IPI00 2 4 6.30% 333 36031 8.4 U Tax_Id=10090 Gene_Symbol=Gm3200 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.20% 337 36250 8.3 U Tax_Id=10090 Gene_Symbol=- 36 kDa protein IPI:IPI00 2 4 6.30% 333 35776 8.2 U Tax_Id=10090 Gene_Symbol=- 36 kDa protein IPI:IPI00 2 4 6.30% 333 35817 8 U Tax_Id=10090 Gene_Symbol=Gm10284 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI008 2 4 6.30% 333 35770 8.4 U Tax_Id=10090 Gene_Symbol=LOC100047232 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1

IPI:IPI008 2 4 5.70% 366 39556 9 U Tax_Id=10090 Gene_Symbol=Gm13464 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.10% 343 37044 8.4 U Tax_Id=10090 Gene_Symbol=Gm3534 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.30% 333 35757 8 U Tax_Id=10090 Gene_Symbol=Gm2606 similar to Glyceraldehyde-3-phosphate dehydrogenase isoform 1 IPI:IPI008 2 4 6.30% 333 35887 8.3 U Tax_Id=10090 Gene_Symbol=Gm13292 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 7.20% 290 31093 8.1 U Tax_Id=10090 Gene_Symbol=Gm10358 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 IPI:IPI00 2 4 6.30% 333 35713 8 U Tax_Id=10090 Gene_Symbol=Gm2451 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI008 2 4 6.30% 333 35782 8.3 U Tax_Id=10090 Gene_Symbol=LOC100048117 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 7.30% 288 30871 7.7 U Tax_Id=10090 Gene_Symbol=- similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 IPI:IPI00 2 4 11.50% 183 20149 6.8 U Tax_Id=10090 Gene_Symbol=LOC100047129 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 7.20% 290 31039 8.4 U Tax_Id=10090 Gene_Symbol=LOC100047232 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 IPI:IPI00 2 4 7.20% 290 31026 7.7 U Tax_Id=10090 Gene_Symbol=Gm2606 similar to Glyceraldehyde-3-phosphate dehydrogenase isoform 3 IPI:IPI00 2 4 5.70% 368 39968 8 U Tax_Id=10090 Gene_Symbol=Gm3222 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI008 2 4 6.30% 333 35812 8.2 U Tax_Id=10090 Gene_Symbol=Gm10358 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI008 2 4 7.20% 290 31140 8.1 U Tax_Id=10090 Gene_Symbol=Gm10284 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 IPI:IPI008 2 4 6.30% 333 35775 8.3 U Tax_Id=10090 Gene_Symbol=LOC100046806;Gm10327 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 6.30% 333 35810 8.4 U Tax_Id=10090 Gene_Symbol=Gm10293;Gapdh similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.30% 331 35533 7.7 U Tax_Id=10090 Gene_Symbol=- similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 6.30% 333 35838 8.4 U Tax_Id=10090 Gene_Symbol=Gm4609 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 13.30% 158 17144 9 U Tax_Id=10090 Gene_Symbol=LOC100044724 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.30% 333 35826 8 U Tax_Id=10090 Gene_Symbol=LOC100045908 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 7.20% 290 31051 8.1 U Tax_Id=10090 Gene_Symbol=Gm2451 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 IPI:IPI00 2 4 6.30% 333 35849 8 U Tax_Id=10090 Gene_Symbol=Gm10291 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI006 2 4 6.30% 333 35914 8.2 U Tax_Id=10090 Gene_Symbol=- similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 6.30% 333 35812 8 U Tax_Id=10090 Gene_Symbol=Gm3839 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 IPI:IPI00 2 4 7.20% 290 31079 8.1 U Tax_Id=10090 Gene_Symbol=LOC100042025 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 IPI:IPI004 2 4 6.30% 335 35794 8.4 U Tax_Id=10090 Gene_Symbol=Gm5507 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.10% 347 37413 8.3 U Tax_Id=10090 Gene_Symbol=LOC100044981 similar to Glyceraldehyde-3-phosphate dehydrogenase IPI:IPI00 2 4 6.30% 333 35810 8.2 U Tax_Id=10090 Gene_Symbol=Gm10293;Gapdh;LOC100042025;Gm10359;Gm2574;Gm5138;Gm12033;Gm3272 Glyceraldehyde-3-phosphate dehydrogenase

FOXO_KO.3 7.3815 0.1319 100 2292.054 2291.054 -1.6 77194.2FOXO_KO.3 3.904 0.3407 99.9 2292.058 2291.054 0.6 108698

IPI:IPI00 1 2 6.30% 252 29726 10.2 U Tax_Id=10090 Gene_Symbol=Mrpl47 39S ribosomal protein L47, mitochondrial * FOXO_KO.2 5.0704 0.452 100 1940.874 1939.871 0.1 111737.4IPI:IPI00 1 1 6.30% 222 25661 8.6 U Tax_Id=10090 Gene_Symbol=Sfrs9 Splicing factor, arginine/serine-rich 9 * FOXO_KO.1 3.1873 0.3238 99.9 1653.749 1653.75 -0.6 153064.8IPI:IPI00 1 1 6.30% 206 23195 10.1 U Tax_Id=10090 Gene_Symbol=Gm5766 Putative uncharacterized protein IPI:IPI00 1 1 4.90% 265 29839 10.2 U Tax_Id=10090 Gene_Symbol=- 30 kDa protein

FOXO_KO.1 3.9327 0.4417 100 1345.731 1345.732 -0.7 236899.1IPI:IPI00 2 5 6.20% 660 75674 7.6 U Tax_Id=10090 Gene_Symbol=Rars Arginyl-tRNA synthetase, cytoplasmic * FOXO_KO.4 6.2977 0.5205 100 2730.462 2728.477 -7.7 94683.1* FOXO_KO.1 5.0905 0.4548 100 1677.772 1676.765 2.4 160035.1IPI:IPI00 3 4 6.20% 529 61179 7.1 U Tax_Id=10090 Gene_Symbol=Oasl1 Putative uncharacterized protein * FOXO_KO.4 6.1399 0.5172 100 2264.169 2263.16 2.2 92647.6* FOXO_KO.4 3.3778 0.2812 99.8 2263.16 2263.16 0 101258.1* FOXO_KO.3 3.7985 0.3887 99.9 1924.931 1923.928 0.2 168796.6IPI:IPI00 1 1 6.20% 533 60001 8.7 U Tax_Id=10090 Gene_Symbol=Fmo5;LOC100046051 flavin containing monooxygenase 5 IPI:IPI00 1 1 7.10% 467 52071 9 U Tax_Id=10090 Gene_Symbol=LOC100046051 similar to Flavin containing monooxygenase 5 isoform 3

FOXO_KO.5 3.6741 0.2237 99.5 3739.927 3737.921 -0.2 20062IPI:IPI00 3 3 6.20% 535 57477 6.4 U Tax_Id=10090 Gene_Symbol=Cct2 T-complex protein 1 subunit beta

IPI:IPI006 3 3 6.80% 488 52469 6.3 U Tax_Id=10090 Gene_Symbol=Cct2 Brain cDNA, clone MNCb-1272, similar to Mus musculus chaperonin subunit 2 (beta) (Cct2), mRNA FOXO_KO.3 6.3275 0.5873 100 2289.169 2288.162 1.8 91341FOXO_KO.3 4.054 0.3682 99.9 2289.168 2288.162 1.4 126328.4FOXO_KO.1 3.9503 0.2924 100 1282.665 1282.664 1.3 36135.1

IPI:IPI00 1 2 6.20% 518 52673 9.4 U Tax_Id=10090 Gene_Symbol=Fus RNA-binding protein FUS IPI:IPI00 1 2 6.20% 517 52602 9.4 U Tax_Id=10090 Gene_Symbol=Fus 53 kDa protein

FOXO_KO.3 5.5889 0.4823 100 3585.627 3585.625 0.5 83238.6IPI:IPI00 2 2 6.20% 406 46519 6.4 U Tax_Id=10090 Gene_Symbol=Phkg2 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform IPI:IPI00 2 2 6.20% 406 46572 6.5 U Tax_Id=10090 Gene_Symbol=Phkg2 phosphorylase kinase, gamma 2

FOXO_KO.3 5.5336 0.5776 100 2619.325 2618.32 0.6 25589.7FOXO_KO.3 4.1554 0.3063 99.9 2619.324 2618.32 0.4 159429.7

IPI:IPI00 1 1 6.20% 288 31254 7.6 U Tax_Id=10090 Gene_Symbol=Smn1 Survival motor neuron protein * FOXO_KO.2 4.9706 0.48 100 1937.876 1936.877 -2.3 98371IPI:IPI00 1 1 6.20% 194 22587 9.1 U Tax_Id=10090 Gene_Symbol=Gstm1 23 kDa protein

FOXO_KO.1 3.5502 0.4729 100 1390.663 1390.663 -0.1 237705.5IPI:IPI00 1 1 6.20% 192 20680 9.7 U Tax_Id=10090 Gene_Symbol=Mrpl11 39S ribosomal protein L11, mitochondrial * FOXO_KO.2 4.89 0.4756 100 1379.668 1379.669 -0.6 239012.3IPI:IPI00 1 1 6.20% 145 17091 10.4 U Tax_Id=10090 Gene_Symbol=Rpl26l1 similar to ribosomal protein L26

FOXO_KO.1 2.6118 0.239 99.6 1082.525 1082.527 -1.1 327202.9IPI:IPI00 4 6 6.10% 1048 118875 7.9 U Tax_Id=10090 Gene_Symbol=Farp1 FERMRhoGEF (Arhgef) and pleckstrin domain protein 1 IPI:IPI00 4 6 6.10% 1048 118901 7.9 U Tax_Id=10090 Gene_Symbol=LOC100045542 similar to FERMRhoGEF (Arhgef) and pleckstrin domain protein 1

FOXO_KO.1 3.2766 0.3916 100 1523.707 1523.71 -2.3 224674.3FOXO_KO.5 4.3171 0.3298 99.9 3204.557 3203.553 0.3 43758.2FOXO_KO.4 3.7986 0.3388 99.9 3783.881 3781.87 1.2 107135FOXO_KO.1 3.9738 0.3718 100 1799.858 1798.856 -0.8 122908.5

IPI:IPI00 1 1 6.10% 751 77972 8.5 U Tax_Id=10090 Gene_Symbol=Dach1 Isoform 1 of Dachshund homolog 1 IPI:IPI00 1 1 29.70% 155 13663 5.7 U Tax_Id=10090 Gene_Symbol=Dach1 Dach1 protein IPI:IPI00 1 1 6.60% 699 72534 8.5 U Tax_Id=10090 Gene_Symbol=Dach1 Isoform 2 of Dachshund homolog 1

FOXO_KO.2 4.3855 0.2263 100 4472.183 4471.157 5 68995.3IPI:IPI00 1 1 6.10% 445 49953 4.9 U Tax_Id=10090 Gene_Symbol=Tubb2b Tubulin beta-2B chain IPI:IPI00 1 1 6.10% 445 49907 4.9 U Tax_Id=10090 Gene_Symbol=Tubb2a Tubulin beta-2A chain

FOXO_KO.2 6.2121 0.2871 99.9 3103.412 3102.408 0.3 132290.3IPI:IPI00 1 3 6.10% 444 49671 4.9 U Tax_Id=10090 Gene_Symbol=Tubb5 Tubulin beta-5 chain * FOXO_KO.2 5.3599 0.2583 99.9 3104.415 3102.408 0.3 92452.9IPI:IPI00 1 2 6.10% 444 49586 4.9 U Tax_Id=10090 Gene_Symbol=Tubb4 Tubulin beta-4 chain IPI:IPI00 1 2 6.10% 445 49831 4.9 U Tax_Id=10090 Gene_Symbol=Tubb2c Tubulin beta-2C chain

FOXO_KO.2 5.7577 0.4271 100 3117.423 3116.423 -1.2 120910IPI:IPI001 1 1 6.10% 425 47558 5.6 U Tax_Id=10090 Gene_Symbol=BC003331 Isoform 2 of Protein odr-4 homolog IPI:IPI00 1 1 5.80% 445 50010 6.4 U Tax_Id=10090 Gene_Symbol=BC003331 50 kDa protein IPI:IPI006 1 1 6.30% 415 46496 6.3 U Tax_Id=10090 Gene_Symbol=BC003331 Isoform 3 of Protein odr-4 homolog IPI:IPI006 1 1 5.80% 447 49998 6.1 U Tax_Id=10090 Gene_Symbol=BC003331 Isoform 1 of Protein odr-4 homolog

FOXO_KO.4 5.1124 0.4639 100 3100.628 3100.623 1.6 57093.2IPI:IPI00 1 2 6.10% 296 34098 8.3 U Tax_Id=10090 Gene_Symbol=Glyat Isoform 1 of Glycine N-acyltransferase IPI:IPI00 1 2 6.90% 262 30150 7.8 U Tax_Id=10090 Gene_Symbol=Glyat Isoform 2 of Glycine N-acyltransferase

FOXO_KO.2 7.3177 0.5572 100 2224.004 2223.002 -0.7 79899IPI:IPI00 7 7 6.00% 1575 180527 5.6 U Tax_Id=10090 Gene_Symbol=Iqgap2 Ras GTPase-activating-like protein IQGAP2 * FOXO_KO.2 3.7889 0.4151 100 2182.018 2181.013 0.8 63571.4* FOXO_KO.4 6.2571 0.5499 100 2370.178 2369.173 0.7 80684.6

* FOXO_KO.4 4.6521 0.38 100 2370.183 2369.173 2.6 235125.9* FOXO_KO.1 6.5042 0.4754 100 2023.927 2022.925 -0.7 114853.2* FOXO_KO.5 5.302 0.531 100 2612.225 2612.225 -0.1 31181* FOXO_KO.1 5.2743 0.4236 100 1869.839 1868.837 -0.9 101054.9* FOXO_KO.1 5.222 0.5019 100 1741.74 1740.742 -3.2 171428.8IPI:IPI00 3 5 6.00% 689 76203 8.4 U Tax_Id=10090 Gene_Symbol=Slc27a5 Bile acyl-CoA synthetase

FOXO_KO.3 6.0467 0.3993 100 2453.287 2452.282 0.7 41267.7FOXO_KO.3 3.9964 0.3227 99.9 2453.285 2452.282 -0.1 151540.3

* FOXO_KO.4 5.1999 0.5215 100 1993.04 1992.033 2.2 125764.2IPI:IPI00 1 1 6.00% 447 50090 4.9 U Tax_Id=10090 Gene_Symbol=Tubb6 Tubulin beta-6 chain * FOXO_KO.3 5.0475 0.2247 99.9 2993.418 2991.412 -0.2 81743.6IPI:IPI00 2 2 6.00% 335 36260 6.8 U Tax_Id=10090 Gene_Symbol=Arg1 Arginase-1 * FOXO_KO_w 2.4086 0.3062 99.7 1152.589 1152.59 -0.7 71073.6* FOXO_KO.1 3.4062 0.2796 99.9 1285.64 1285.642 -2 287721.1IPI:IPI00 1 1 6.00% 299 33407 5.3 U Tax_Id=10090 Gene_Symbol=Rgn Regucalcin * FOXO_KO.1 5.4564 0.3728 100 2065.884 2065.888 -1.7 117968.1IPI:IPI00 1 1 6.00% 299 32989 7.5 U Tax_Id=10090 Gene_Symbol=Zfr Protein

FOXO_KO.1 3.5404 0.2324 99.8 1930.921 1929.922 -2.4 138345.8IPI:IPI00 2 2 6.00% 249 28673 6 U Tax_Id=10090 Gene_Symbol=Psme1 Proteasome activator complex subunit 1 * FOXO_KO.1 5.7506 0.5149 100 1872.917 1871.913 0.3 102968.3* FOXO_KO.1 3.3781 0.2276 99.5 1871.912 1871.913 -0.6 278801.2IPI:IPI00 1 1 6.00% 201 22230 7 U Tax_Id=10090 Gene_Symbol=Dlst Isoform 2 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

FOXO_KO.1 4.2415 0.4722 100 1455.658 1454.658 -2 311857.5IPI:IPI00 2 11 6.00% 200 21820 6.8 U Tax_Id=10090 Gene_Symbol=Foxo4 Putative uncharacterized protein IPI:IPI00 2 11 4.90% 244 25897 4.7 U Tax_Id=10090 Gene_Symbol=Foxo3 26 kDa protein

FOXO_KO.1 3.0161 0.3618 100 1251.558 1251.56 -1.6 87628.9FOXO_KO.1 3.8266 0.3195 100 1251.558 1251.56 -1.6 2042793

IPI:IPI00 6 7 5.90% 1719 195893 5.8 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 2 of Myosin-XVIIIa IPI:IPI00 6 7 5.90% 1704 194046 5.7 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 5 of Myosin-XVIIIa IPI:IPI00 6 7 5.90% 1716 195276 5.7 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 7 of Myosin-XVIIIa IPI:IPI00 6 7 4.90% 2062 233983 6.2 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 6 of Myosin-XVIIIa IPI:IPI00 6 7 5.00% 2035 230906 6.2 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 1 of Myosin-XVIIIa IPI:IPI00 6 7 4.90% 2050 232753 6.3 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 3 of Myosin-XVIIIa

FOXO_KO.3 4.097 0.331 100 1487.783 1487.784 -0.7 143555.8FOXO_KO.2 5.0569 0.3912 100 3166.504 3165.503 -0.8 54933.8FOXO_KO.1 5.924 0.4791 100 1792.838 1791.835 -0.6 127003.6FOXO_KO.3 4.8086 0.4669 100 2577.299 2576.294 0.6 154869FOXO_KO.2 4.4022 0.3609 99.9 2519.195 2518.198 -2.6 163647.2FOXO_KO.1 4.068 0.2178 99.9 1623.685 1623.688 -1.7 115512.2

IPI:IPI00 4 8 5.90% 1216 137616 5.6 U Tax_Id=10090 Gene_Symbol=Eif5b Eukaryotic translation initiation factor 5B * FOXO_KO.2 7.7806 0.6162 100 2436.147 2435.142 0.6 61486.1* FOXO_KO.2 3.759 0.2818 99.8 2436.142 2435.142 -1.5 189215* FOXO_KO.1 4.061 0.4545 100 1798.762 1798.761 0.5 113493* FOXO_KO.5 5.3438 0.4468 100 3280.747 3278.737 0.9 66362.5IPI:IPI00 3 3 5.90% 859 96002 6.6 U Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 1 of Heterogeneous nuclear ribonucleoprotein U-like protein 1 IPI:IPI00 3 3 6.70% 759 85046 8.7 U Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 2 of Heterogeneous nuclear ribonucleoprotein U-like protein 1

FOXO_KO.3 3.909 0.2124 99.6 3946.692 3945.691 -0.5 172739.5FOXO_KO.1 3.966 0.2958 99.9 2070.001 2068.997 0.4 356204.5

FOXO_KO.1 3.3352 0.3447 99.9 1913.895 1912.896 -2.1 177980.1IPI:IPI00 3 3 5.90% 733 84788 5 U Tax_Id=10090 Gene_Symbol=Hsp90aa1 Heat shock protein HSP 90-alpha * FOXO_KO.1 5.5386 0.4339 100 1834.785 1833.781 0.1 192539.2* FOXO_KO.2 3.0466 0.304 99.8 2131.044 2130.042 -0.8 257099.4* FOXO_KO.9 3.3419 0.2991 99.9 1235.6 1235.601 -0.9 370309.2IPI:IPI001 1 1 5.90% 546 61260 5.4 U Tax_Id=10090 Gene_Symbol=Cttn Src substrate cortactin IPI:IPI00 1 1 5.90% 546 61250 5.4 U Tax_Id=10090 Gene_Symbol=Cttn Cortactin, isoform CRA_e IPI:IPI00 1 1 6.30% 509 57086 5.3 U Tax_Id=10090 Gene_Symbol=Cttn Putative uncharacterized protein

FOXO_KO.2 5.4568 0.4747 100 3349.444 3348.441 -0.3 85317.8IPI:IPI00 1 2 5.90% 475 52466 7.3 U Tax_Id=10090 Gene_Symbol=Dnpep aspartyl aminopeptidase isoform a IPI:IPI00 1 2 5.90% 473 52207 7.3 U Tax_Id=10090 Gene_Symbol=Dnpep aspartyl aminopeptidase isoform b

FOXO_KO.4 4.7364 0.4203 100 3133.628 3132.621 1 80676.9IPI:IPI00 1 1 5.90% 456 50405 8 U Tax_Id=10090 Gene_Symbol=Wdr4 WD repeat domain 4 * FOXO_KO.1 3.8699 0.2703 99.8 2725.254 2724.248 0.7 134010.2IPI:IPI00 2 2 5.90% 376 42809 5.7 U Tax_Id=10090 Gene_Symbol=Psmd13 Isoform 1 of 26S proteasome non-ATPase regulatory subunit 13 IPI:IPI00 2 2 6.50% 337 38196 5.8 U Tax_Id=10090 Gene_Symbol=Psmd13 Isoform 2 of 26S proteasome non-ATPase regulatory subunit 13

FOXO_KO.3 5.6606 0.3989 100 2470.198 2469.193 0.6 91282.5FOXO_KO.3 5.0904 0.4291 100 2470.194 2469.193 -0.8 196043.5

IPI:IPI00 1 1 5.90% 358 40430 7 U Tax_Id=10090 Gene_Symbol=Lman2 Lectin, mannose-binding 2 IPI:IPI00 1 1 5.90% 358 40416 7 U Tax_Id=10090 Gene_Symbol=Lman2 Vesicular integral-membrane protein VIP36

FOXO_KO.3 4.5199 0.3189 99.9 2469.137 2468.137 -1.3 153492.3IPI:IPI00 1 1 5.90% 339 37280 5.9 U Tax_Id=10090 Gene_Symbol=Ctsb Cathepsin B * FOXO_KO.3 6.0556 0.4862 100 2172.908 2172.907 0.1 111096.2IPI:IPI00 1 2 5.90% 289 31818 6.1 U Tax_Id=10090 Gene_Symbol=Fhl3 Four and a half LIM domains protein 3 IPI:IPI00 1 2 5.90% 289 31795 6.2 U Tax_Id=10090 Gene_Symbol=Fhl3 four and a half LIM domains 3 IPI:IPI00 1 2 6.10% 280 31165 6.3 U Tax_Id=10090 Gene_Symbol=Fhl3 Four and a half LIM domains 3

FOXO_KO.3 4.3242 0.4293 100 2003.854 2003.851 1.3 94258.7IPI:IPI00 1 1 5.90% 239 27057 5.7 U Tax_Id=10090 Gene_Symbol=Psme2 Proteasome activator complex subunit 2 IPI:IPI00 1 1 5.60% 252 28311 5.8 U Tax_Id=10090 Gene_Symbol=Psme2 proteasome activator subunit 2 isoform 2

FOXO_KO.1 3.0598 0.315 99.9 1534.724 1534.738 -9.2 156909.4IPI:IPI002 12 15 5.80% 2603 284989 12 U Tax_Id=10090 Gene_Symbol=Srrm2 Isoform 3 of Serine/arginine repetitive matrix protein 2 IPI:IPI007 12 15 5.50% 2703 294676 12 U Tax_Id=10090 Gene_Symbol=Srrm2 Isoform 1 of Serine/arginine repetitive matrix protein 2

FOXO_KO.2 6.5049 0.3722 100 2674.136 2673.137 -1.6 59702.1FOXO_KO.2 6.1346 0.4616 100 2674.137 2673.137 -1.1 229087.7FOXO_KO.1 6.4949 0.4869 100 2506.259 2505.258 -0.9 48679.2FOXO_KO.1 4.0731 0.2917 99.9 2505.254 2505.258 -1.7 171995.1FOXO_KO.1 5.5424 0.4682 100 2640.138 2638.138 -2.5 181300FOXO_KO.1 5.4483 0.4632 100 2638.137 2638.138 -0.6 136576.3FOXO_KO.1 4.3409 0.4102 100 2719.107 2718.105 -0.4 121891.7FOXO_KO.1 3.7892 0.3699 100 2015.949 2014.948 -1.1 81585.4FOXO_KO.2 3.5827 0.3518 100 1819.879 1818.879 -1.7 113795.2FOXO_KO.2 5.1176 0.615 100 2224.989 2224.007 -9.7 74684.1FOXO_KO_w 3.6421 0.2992 99.9 1733.814 1732.813 -1.2 28994.8FOXO_KO.1 3.4088 0.2964 99.9 1612.72 1610.718 -2.6 217837.5

IPI:IPI00 4 6 5.80% 729 77649 8.6 U Tax_Id=10090 Gene_Symbol=Hnrnpm Isoform 1 of Heterogeneous nuclear ribonucleoprotein M IPI:IPI00 4 6 6.10% 690 73741 8.7 U Tax_Id=10090 Gene_Symbol=Hnrnpm Isoform 2 of Heterogeneous nuclear ribonucleoprotein M

FOXO_KO.3 3.5608 0.3175 99.9 2011.013 2010.01 -0.3 134746.1FOXO_KO.3 6.139 0.4822 100 1753.878 1752.872 1.4 165198.4

FOXO_KO.1 3.0957 0.3024 99.9 1808.862 1808.864 -1 222413.7FOXO_KO.9 2.8807 0.3232 99.9 1063.505 1063.506 -0.3 333891.2

IPI:IPI00 2 3 5.80% 568 63677 9.1 U Tax_Id=10090 Gene_Symbol=Sgpl1 Sphingosine-1-phosphate lyase 1 IPI:IPI00 2 3 6.80% 487 54770 9 U Tax_Id=10090 Gene_Symbol=Sgpl1 55 kDa protein

FOXO_KO.3 4.3065 0.3153 99.9 2077.068 2075.058 1.6 343942.8FOXO_KO.1 3.5774 0.3207 99.9 1682.834 1682.838 -2.4 153378.9

IPI:IPI00 1 1 5.80% 571 63318 6.1 U Tax_Id=10090 Gene_Symbol=Es31 Isoform 1 of Liver carboxylesterase 31 IPI:IPI00 1 1 6.30% 524 57858 5.6 U Tax_Id=10090 Gene_Symbol=Es31 Isoform 2 of Liver carboxylesterase 31

FOXO_KO.4 3.9227 0.3125 99.9 3573.648 3571.639 0.8 100190.5IPI:IPI00 1 2 5.80% 530 59929 5.1 U Tax_Id=10090 Gene_Symbol=Capn2 Putative uncharacterized protein

FOXO_KO.3 4.6305 0.4343 100 3599.616 3597.61 -0.3 76424.4IPI:IPI00 2 3 5.80% 465 51922 10 U Tax_Id=10090 Gene_Symbol=Rsl1d1 Putative uncharacterized protein * FOXO_KO.2 3.597 0.2363 99.5 3081.549 3080.546 -0.1 92145.1* FOXO_KO.2 4.3103 0.2292 99.7 2826.399 2824.392 0 120524.6IPI:IPI00 2 2 5.80% 433 48162 5.1 U Tax_Id=10090 Gene_Symbol=Krt17 Keratin, type I cytoskeletal 17

FOXO_KO.1 4.1804 0.3014 100 1345.684 1345.685 -0.6 200397.3* FOXO_KO.2 5.1377 0.4559 100 1618.746 1617.743 -0.5 298061.7IPI:IPI00 1 1 5.80% 191 20917 6 U Tax_Id=10090 Gene_Symbol=Echs1 Protein

FOXO_KO.1 3.2652 0.3382 100 1289.638 1289.641 -2 229340.9IPI:IPI00 5 6 5.70% 1124 123967 6.6 U Tax_Id=10090 Gene_Symbol=Upf1 Isoform 1 of Regulator of nonsense transcripts 1 IPI:IPI00 5 6 5.80% 1113 122657 6.7 U Tax_Id=10090 Gene_Symbol=Upf1 Isoform 2 of Regulator of nonsense transcripts 1

FOXO_KO.3 5.767 0.3333 100 2539.14 2538.141 -1.6 48516.5FOXO_KO.2 6.2853 0.373 100 2817.417 2815.411 -0.4 131998.8FOXO_KO.1 5.608 0.3777 100 1890.933 1890.929 1.8 96152.5FOXO_KO.1 4.0783 0.3433 99.9 1891.934 1890.929 0.8 188763.3FOXO_KO.1 3.4319 0.3047 99.9 2048.034 2047.03 0.1 235582

IPI:IPI00 2 2 5.70% 612 68701 6.9 U Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 4 of Dynamin-1-like protein FOXO_KO.3 4.1147 0.1407 99.6 2301.067 2300.068 -1.8 102786.8FOXO_KO.4 5.9341 0.4626 100 1923.901 1922.901 -1.6 201914.2

IPI:IPI00 1 2 5.70% 583 63417 8.3 U Tax_Id=10090 Gene_Symbol=Eefsec Selenocysteine-specific elongation factor IPI:IPI00 1 2 5.70% 583 63539 8.3 U Tax_Id=10090 Gene_Symbol=Eefsec eukaryotic elongation factor, selenocysteine-tRNA-specific

FOXO_KO.4 4.5302 0.3005 99.9 3292.808 3292.804 1.3 88182IPI:IPI00 1 1 5.70% 546 60756 6.5 U Tax_Id=10090 Gene_Symbol=Suox Sulfite oxidase, mitochondrial * FOXO_KO.2 3.7511 0.3973 99.9 3380.598 3378.591 0.3 188845.6IPI:IPI001 2 2 5.70% 547 59126 7.4 U Tax_Id=10090 Gene_Symbol=Scp2 Isoform SCPx of Non-specific lipid-transfer protein

FOXO_KO.3 6.5819 0.5748 100 2269.082 2268.077 0.6 109938.8FOXO_KO.9 4.1362 0.3403 100 1335.678 1335.679 -1.1 263941.5

IPI:IPI00 1 1 5.70% 435 49799 6.6 U Tax_Id=10090 Gene_Symbol=Ecsit Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial * FOXO_KO.3 4.0417 0.2228 99.5 3059.47 3057.461 0.5 70162.4IPI:IPI00 1 2 5.70% 384 43881 8.5 U Tax_Id=10090 Gene_Symbol=Mrps31 28S ribosomal protein S31, mitochondrial * FOXO_KO.3 5.4419 0.5185 100 2461.158 2460.161 -2.3 45767.2IPI:IPI00 1 2 5.70% 369 39290 9.8 U Tax_Id=10090 Gene_Symbol=H2afy Isoform 1 of Core histone macro-H2A.1 IPI:IPI00 1 2 5.70% 371 39607 9.8 U Tax_Id=10090 Gene_Symbol=H2afy H2A histone family, member Y isoform 2 IPI:IPI00 1 2 5.70% 368 39161 9.8 U Tax_Id=10090 Gene_Symbol=H2afy H2A histone family, member Y isoform 4 IPI:IPI00 1 2 5.60% 372 39735 9.8 U Tax_Id=10090 Gene_Symbol=H2afy Isoform 2 of Core histone macro-H2A.1

FOXO_KO.2 5.9107 0.4707 100 2531.208 2531.206 0.9 273894.8IPI:IPI00 3 3 5.60% 953 107066 6 U Tax_Id=10090 Gene_Symbol=Copb1 Coatomer subunit beta * FOXO_KO.4 6.5076 0.5046 100 2492.274 2490.266 0.5 235655.3

* FOXO_KO.2 3.9772 0.3843 100 1707.755 1707.757 -0.9 26353.6* FOXO_KO.1 5.6584 0.4516 100 1954.017 1953.018 -2 106526.4IPI:IPI00 2 2 5.60% 641 72370 5.2 U Tax_Id=10090 Gene_Symbol=Pdia4 protein disulfide isomerase A4 * FOXO_KO.2 6.4876 0.5525 100 2248.099 2247.099 -1.3 88068.5* FOXO_KO.2 3.5995 0.4055 100 1687.726 1686.732 -5.5 464342.7IPI:IPI00 2 3 5.60% 608 69484 6.8 U Tax_Id=10090 Gene_Symbol=Xrcc6 ATP-dependent DNA helicase 2 subunit 1 * FOXO_KO.2 6.6412 0.5808 100 2235.029 2235.03 -0.3 101408.8* FOXO_KO.1 4.5411 0.4562 100 1743.947 1743.949 -1 101598.3IPI:IPI00 1 1 5.60% 604 67581 9.1 U Tax_Id=10090 Gene_Symbol=Araf Serine/threonine-protein kinase A-Raf IPI:IPI00 1 1 8.10% 419 46255 9.3 U Tax_Id=10090 Gene_Symbol=Araf Putative uncharacterized protein IPI:IPI00 1 1 18.30% 186 20885 8.5 U Tax_Id=10090 Gene_Symbol=Araf v-raf murine sarcoma 3611 viral oncogene homolog isoform 2 IPI:IPI00 1 1 14.80% 230 25708 8.3 U Tax_Id=10090 Gene_Symbol=Araf V-raf murine sarcoma 3611 viral oncogene homolog

FOXO_KO.5 3.2108 0.2877 99.7 3794.945 3793.936 1.7 13968.9IPI:IPI00 1 1 5.60% 425 49461 9.1 U Tax_Id=10090 Gene_Symbol=Iqcd Isoform 2 of IQ domain-containing protein D IPI:IPI00 1 1 5.20% 458 53351 9.2 U Tax_Id=10090 Gene_Symbol=Iqcd Isoform 1 of IQ domain-containing protein D

FOXO_KO.5 3.7077 0.2481 99.7 3015.433 3015.445 -3.9 23563.2IPI:IPI00 1 2 5.60% 414 48386 9.4 U Tax_Id=10090 Gene_Symbol=Rg9mtd1 Mitochondrial ribonuclease P protein 1 * FOXO_KO.1 3.7754 0.2375 99.6 2456.121 2454.111 1.2 201069.1IPI:IPI00 1 2 5.60% 429 45349 8.5 U Tax_Id=10090 Gene_Symbol=Fam98b Protein FAM98B * FOXO_KO.4 6.2916 0.5492 100 2522.207 2521.201 0.8 48760.8IPI:IPI00 1 1 5.60% 393 43772 4.9 U Tax_Id=10090 Gene_Symbol=Cbwd1 Isoform 1 of COBW domain-containing protein 1 IPI:IPI00 1 1 8.10% 272 30401 5.3 U Tax_Id=10090 Gene_Symbol=Cbwd1 Isoform 2 of COBW domain-containing protein 1

FOXO_KO.4 4.2052 0.3644 99.9 2531.316 2530.315 -0.7 128661IPI:IPI00 1 2 5.60% 355 40533 4.8 U Tax_Id=10090 Gene_Symbol=Atxn3 Ataxin-3 IPI:IPI00 1 2 7.00% 287 32959 4.7 U Tax_Id=10090 Gene_Symbol=Atxn3 33 kDa protein IPI:IPI00 1 2 6.80% 296 33757 4.8 U Tax_Id=10090 Gene_Symbol=Atxn3 Atxn3 protein IPI:IPI00 1 2 6.90% 291 33435 4.7 U Tax_Id=10090 Gene_Symbol=Atxn3 ataxin 3 isoform 2

FOXO_KO.2 6.6338 0.449 100 2194.982 2193.978 0 125778.9IPI:IPI00 1 2 5.60% 338 36912 6.6 U Tax_Id=10090 Gene_Symbol=Fbp1 Fructose-1,6-bisphosphatase 1 IPI:IPI00 1 2 14.30% 133 14473 5 U Tax_Id=10090 Gene_Symbol=Fbp1 Fructose-1,6-bisphosphatase

FOXO_KO.3 7.927 0.5216 100 2171.058 2169.053 -0.8 126364.8IPI:IPI00 1 1 5.60% 286 32967 5.8 U Tax_Id=10090 Gene_Symbol=Capza2 F-actin-capping protein subunit alpha-2 * FOXO_KO.1 4.3739 0.269 99.9 1748.871 1747.871 -1.6 151655.7IPI:IPI00 1 3 5.60% 198 22382 6.1 U Tax_Id=10090 Gene_Symbol=Sar1b GTP-binding protein SAR1b * FOXO_KO.1 2.9204 0.307 99.9 1314.665 1314.665 0.2 43907.5IPI:IPI001 1 1 5.60% 197 22182 8.4 U Tax_Id=10090 Gene_Symbol=Gpx4 Isoform Mitochondrial of Phospholipid hydroperoxide glutathione peroxidase, mitochondrial IPI:IPI006 1 1 4.30% 253 29147 10.2 U Tax_Id=10090 Gene_Symbol=Gpx4 glutathione peroxidase 4 isoform 1 precursor IPI:IPI00 1 1 4.30% 253 29205 10.1 U Tax_Id=10090 Gene_Symbol=Gpx4 Phospholipid hydroperoxide glutathione peroxidase, nuclear

FOXO_KO.1 4.1191 0.3563 100 1302.581 1302.582 -0.6 479366IPI:IPI00 1 3 5.60% 178 20271 9.4 U Tax_Id=10090 Gene_Symbol=Gm7589 hypothetical protein IPI:IPI00 1 3 3.60% 279 31626 9.6 U Tax_Id=10090 Gene_Symbol=LOC100045024 similar to ribosomal protein L11 IPI:IPI00 1 3 5.50% 181 20634 9.7 U Tax_Id=10090 Gene_Symbol=Rpl11 Ribosomal protein L11 IPI:IPI00 1 3 5.60% 178 20279 9.6 U Tax_Id=10090 Gene_Symbol=Gm10288 similar to ribosomal protein L11 IPI:IPI00 1 3 5.60% 178 20266 9.5 U Tax_Id=10090 Gene_Symbol=Gm10036 similar to ribosomal protein L11 IPI:IPI003 1 3 5.10% 198 22708 9.8 U Tax_Id=10090 Gene_Symbol=Gm5093 similar to ribosomal protein L11 IPI:IPI00 1 3 5.60% 178 20252 9.6 U Tax_Id=10090 Gene_Symbol=Rpl11 60S ribosomal protein L11

FOXO_KO_w 3.1752 0.189 99.7 1087.6 1087.599 0.9 99491.1IPI:IPI00 3 3 5.50% 676 74467 8.6 U Tax_Id=10090 Gene_Symbol=Slc25a13 Calcium-binding mitochondrial carrier protein Aralar2

* FOXO_KO.1 4.9945 0.4683 100 1677.868 1677.869 -0.9 184761.2* FOXO_KO.1 3.2248 0.3162 99.9 1677.867 1677.869 -1.2 220399.9* FOXO_KO.5 4.5764 0.4715 100 2581.301 2581.301 0.2 21065.9IPI:IPI00 2 6 5.50% 642 70176 5.7 U Tax_Id=10090 Gene_Symbol=Hspa1b Heat shock 70 kDa protein 1B IPI:IPI00 2 6 5.50% 641 70131 5.7 U Tax_Id=10090 Gene_Symbol=Hspa1a Inducible heat shock protein 70

FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.2 4.6041 0.4777 100 2775.328 2774.327 -0.9 24134.5

IPI:IPI00 2 2 5.50% 559 64279 5.9 U Tax_Id=10090 Gene_Symbol=Nars Asparaginyl-tRNA synthetase, cytoplasmic IPI:IPI00 2 2 5.60% 558 64208 5.9 U Tax_Id=10090 Gene_Symbol=Nars asparaginyl-tRNA synthetase isoform 2

FOXO_KO.2 4.9646 0.4779 100 2087.888 2086.888 -1.6 176620.1FOXO_KO.1 4.6465 0.4205 100 1612.768 1611.765 0 315013.4

IPI:IPI00 1 1 5.50% 524 59047 7.3 U Tax_Id=10090 Gene_Symbol=Api5 Putative uncharacterized protein IPI:IPI008 1 1 9.60% 303 34002 6.3 U Tax_Id=10090 Gene_Symbol=Gm2981 similar to Apoptosis inhibitor 5 IPI:IPI007 1 1 5.80% 504 56771 5.8 U Tax_Id=10090 Gene_Symbol=Api5 Apoptosis inhibitor 5

FOXO_KO.6 4.487 0.4501 100 3206.704 3205.699 0.4 35431.4IPI:IPI00 2 3 5.50% 530 58951 6.9 U Tax_Id=10090 Gene_Symbol=Ahcyl1 Putative adenosylhomocysteinase 2 IPI:IPI00 2 3 15.90% 182 19845 5 U Tax_Id=10090 Gene_Symbol=Ahcyl1 Protein IPI:IPI00 2 3 13.80% 210 23300 6 U Tax_Id=10090 Gene_Symbol=Ahcyl1 23 kDa protein

FOXO_KO.3 4.685 0.3732 100 1818.935 1817.931 0.2 167975.2FOXO_KO.3 4.9599 0.5127 100 1715.684 1714.68 0 220990.6

IPI:IPI00 2 4 5.50% 475 51386 9.4 U Tax_Id=10090 Gene_Symbol=Hadhb Trifunctional enzyme subunit beta, mitochondrial IPI:IPI004 2 4 5.50% 475 51367 9.3 U Tax_Id=10090 Gene_Symbol=Gm13910 similar to Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

FOXO_KO.4 4.7157 0.3591 100 1838.999 1837.995 0.8 47714.7FOXO_KO.1 3.1789 0.2756 99.9 1211.592 1211.594 -1.6 236144

IPI:IPI00 2 4 5.50% 418 45654 8.8 U Tax_Id=10090 Gene_Symbol=Slc27a5 46 kDa protein FOXO_KO.3 6.0467 0.3993 100 2453.287 2452.282 0.7 41267.7FOXO_KO.3 3.9964 0.3227 99.9 2453.285 2452.282 -0.1 151540.3

IPI:IPI00 1 1 5.50% 379 44593 5.3 U Tax_Id=10090 Gene_Symbol=Cdc37 Hsp90 co-chaperone Cdc37 * FOXO_KO.3 5.3619 0.5587 100 2269.164 2269.16 1.7 85164.4IPI:IPI00 1 1 5.50% 364 41874 9.5 U Tax_Id=10090 Gene_Symbol=1110002N22Rik UPF0629 protein C17orf42 homolog IPI:IPI00 1 1 9.00% 222 25465 9.8 U Tax_Id=10090 Gene_Symbol=1110002N22Rik Novel protein

FOXO_KO.1 4.9177 0.5206 100 2071.967 2071.971 -1.9 64443.1IPI:IPI001 1 2 5.50% 362 38222 6.8 U Tax_Id=10090 Gene_Symbol=Pcbp2 Isoform 1 of Poly(rC)-binding protein 2 IPI:IPI00 1 2 8.00% 249 26494 8.9 U Tax_Id=10090 Gene_Symbol=Pcbp3 Pcbp3 protein IPI:IPI004 1 2 5.90% 338 35780 8.1 U Tax_Id=10090 Gene_Symbol=Pcbp3 Isoform 2 of Poly(rC)-binding protein 3 IPI:IPI004 1 2 5.40% 371 39294 7.5 U Tax_Id=10090 Gene_Symbol=Pcbp3 poly(rC) binding protein 3 IPI:IPI00 1 2 5.70% 349 36801 7.1 U Tax_Id=10090 Gene_Symbol=Pcbp2 Isoform 3 of Poly(rC)-binding protein 2 IPI:IPI002 1 2 6.00% 331 34917 8 U Tax_Id=10090 Gene_Symbol=Pcbp2 Isoform 2 of Poly(rC)-binding protein 2 IPI:IPI00 1 2 5.60% 356 37498 7.1 U Tax_Id=10090 Gene_Symbol=Pcbp1 Poly(rC)-binding protein 1

FOXO_KO.1 6.0969 0.4734 100 2090.978 2089.982 -3.7 53273.8IPI:IPI00 1 1 5.50% 307 34175 6.6 U Tax_Id=10090 Gene_Symbol=Ctsz Cathepsin Z * FOXO_KO.1 5.6999 0.4824 100 2153.84 2152.837 -0.1 71471.5IPI:IPI00 2 2 5.50% 253 29996 5.2 U Tax_Id=10090 Gene_Symbol=Cald1 Cald1 protein

FOXO_KO.1 3.5139 0.2415 99.8 1637.837 1637.838 -0.8 166003.7FOXO_KO.1 3.5132 0.4224 100 1337.684 1337.684 0.2 210379.4

IPI:IPI00 1 1 5.50% 236 25415 9.7 U Tax_Id=10090 Gene_Symbol=Cbr4 Carbonyl reductase family member 4 IPI:IPI00 1 1 9.40% 138 15044 7.4 U Tax_Id=10090 Gene_Symbol=Cbr4 15 kDa protein

FOXO_KO.1 3.1985 0.316 99.9 1598.698 1598.7 -1.1 361135.5

IPI:IPI00 1 1 5.50% 217 23564 11 U Tax_Id=10090 Gene_Symbol=Rpl14 60S ribosomal protein L14 IPI:IPI00 1 1 5.60% 216 23493 11 U Tax_Id=10090 Gene_Symbol=Rpl14 Ribosomal protein L14 IPI:IPI00 1 1 5.60% 216 23521 11 U Tax_Id=10090 Gene_Symbol=Gm9811 hypothetical protein IPI:IPI00 1 1 5.30% 227 26316 11.9 U Tax_Id=10090 Gene_Symbol=Rpl14 Putative uncharacterized protein

FOXO_KO.2 4.0824 0.4893 100 1354.767 1354.769 -1.5 224993.5IPI:IPI00 2 2 5.40% 757 86240 4.4 U Tax_Id=10090 Gene_Symbol=Htatsf1 Isoform 1 of HIV Tat-specific factor 1 homolog * FOXO_KO.2 6.1493 0.6055 100 2390.092 2389.086 0.8 77882.5* FOXO_KO.9 5.3341 0.5522 100 2194.98 2194.985 -2 59330.5IPI:IPI00 2 2 5.40% 667 75289 5.6 U Tax_Id=10090 Gene_Symbol=Anxa6 annexin A6 isoform b IPI:IPI00 2 2 5.40% 672 75799 5.5 U Tax_Id=10090 Gene_Symbol=Anxa6 76 kDa protein IPI:IPI00 2 2 5.30% 673 75885 5.5 U Tax_Id=10090 Gene_Symbol=Anxa6 annexin A6 isoform a IPI:IPI005 2 2 5.30% 673 75886 5.5 U Tax_Id=10090 Gene_Symbol=Anxa6 Annexin A6

FOXO_KO.3 5.3911 0.3937 100 2557.136 2556.135 -0.7 203328.1FOXO_KO.3 4.369 0.406 100 1536.817 1536.816 1.2 199279

IPI:IPI003 2 2 5.40% 577 61828 7.5 U Tax_Id=10090 Gene_Symbol=Bag3 BAG family molecular chaperone regulator 3 IPI:IPI00 2 2 5.40% 577 61860 7.3 U Tax_Id=10090 Gene_Symbol=Bag3 BCL2-associated athanogene 3

FOXO_KO.2 3.7361 0.5294 100 1413.722 1413.722 0.3 189396.4FOXO_KO.4 3.8586 0.3286 99.9 2028.007 2027.004 -0.1 51380.9

IPI:IPI00 1 2 5.40% 445 48689 5.2 U Tax_Id=10090 Gene_Symbol=Pdia6 Putative uncharacterized protein IPI:IPI00 1 2 6.10% 391 42858 6.7 U Tax_Id=10090 Gene_Symbol=LOC100046302 similar to Protein disulfide isomerase associated 6

FOXO_KO.4 4.6107 0.2453 99.9 2639.377 2637.366 1.9 75106.2IPI:IPI00 1 2 5.40% 391 44042 6 U Tax_Id=10090 Gene_Symbol=Tor1aip1 torsin A interacting protein 1 isoform 3

FOXO_KO.2 5.8095 0.4362 100 2347.131 2345.126 -0.5 278232.6IPI:IPI00 1 1 5.40% 315 35776 9.1 U Tax_Id=10090 Gene_Symbol=Rhbdd1 Rhomboid domain-containing protein 1 * FOXO_KO.2 5.3662 0.4338 100 2016.923 2015.919 0 192347.6IPI:IPI00 1 2 5.40% 294 30763 7.8 U Tax_Id=10090 Gene_Symbol=Acaa1a;Acaa1b Putative uncharacterized protein

FOXO_KO.1 3.9699 0.3514 100 1810.774 1810.777 -1.6 143707IPI:IPI00 1 2 5.40% 260 29483 6.8 U Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 2 of Peroxisomal coenzyme A diphosphatase NUDT7 IPI:IPI00 1 2 6.50% 216 24603 6.4 U Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 3 of Peroxisomal coenzyme A diphosphatase NUDT7 IPI:IPI00 1 2 8.20% 171 18648 6.1 U Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 5 of Peroxisomal coenzyme A diphosphatase NUDT7 IPI:IPI00 1 2 6.80% 207 23594 6 U Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 4 of Peroxisomal coenzyme A diphosphatase NUDT7 IPI:IPI00 1 2 5.90% 236 26857 6.4 U Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 1 of Peroxisomal coenzyme A diphosphatase NUDT7

FOXO_KO.9 4.4134 0.5651 100 1545.748 1545.75 -1.5 318229.7IPI:IPI00 1 1 5.40% 257 29418 6.2 U Tax_Id=10090 Gene_Symbol=Prdx4 Peroxiredoxin 4

FOXO_KO.1 4.9013 0.5043 100 1624.759 1624.76 -0.5 305191.6IPI:IPI00 1 1 5.40% 260 29175 9.5 U Tax_Id=10090 Gene_Symbol=Dpm1 Dolichol-phosphate mannosyltransferase IPI:IPI00 1 1 11.60% 121 13480 6.5 U Tax_Id=10090 Gene_Symbol=Dpm1 Protein IPI:IPI00 1 1 6.70% 208 23432 9.3 U Tax_Id=10090 Gene_Symbol=Dpm1 Dolichol-phosphate (Beta-D) mannosyltransferase 1

FOXO_KO.2 4.9375 0.4728 100 1591.79 1589.781 1.7 375582IPI:IPI00 1 1 5.40% 203 23464 11 U Tax_Id=10090 Gene_Symbol=Rpl13a;Flt3l 60S ribosomal protein L13a IPI:IPI00 1 1 2.60% 423 48343 10.2 U Tax_Id=10090 Gene_Symbol=Flt3l 48 kDa protein IPI:IPI006 1 1 7.70% 142 16801 10.7 U Tax_Id=10090 Gene_Symbol=LOC638236 similar to 60S ribosomal protein L13a IPI:IPI00 1 1 6.40% 173 20052 11.1 U Tax_Id=10090 Gene_Symbol=Rpl13a Putative uncharacterized protein IPI:IPI00 1 1 5.40% 203 23353 10.3 U Tax_Id=10090 Gene_Symbol=Gm5520 similar to rat ribosomal protein L13a

FOXO_KO.1 2.6813 0.281 99.8 1252.642 1252.642 0 374315.4IPI:IPI00 4 5 5.30% 1512 170052 7.7 U Tax_Id=10090 Gene_Symbol=Eprs Bifunctional aminoacyl-tRNA synthetase IPI:IPI00 4 5 5.30% 1512 169962 7.6 U Tax_Id=10090 Gene_Symbol=LOC633677 Glutamyl-prolyl-tRNA synthetase

FOXO_KO.9 3.2209 0.3218 99.9 1870.831 1870.834 -1.8 195078.4

FOXO_KO.4 4.3367 0.4168 100 2655.288 2655.284 1.5 102176.8FOXO_KO.3 4.898 0.3653 100 1585.844 1585.843 0.5 168038FOXO_KO.6 4.7452 0.3409 99.9 3514.709 3512.701 0.4 42423.4

IPI:IPI003 3 4 5.30% 1169 128604 5.9 U Tax_Id=10090 Gene_Symbol=Ankfy1 Isoform 1 of Ankyrin repeat and FYVE domain-containing protein 1 IPI:IPI00 3 4 5.30% 1169 128652 5.9 U Tax_Id=10090 Gene_Symbol=Ankfy1 ankyrin repeat and FYVE domain containing 1

FOXO_KO.4 3.3132 0.3564 99.9 3211.507 3211.507 -0.1 61234.9FOXO_KO.5 4.6509 0.4266 100 3381.721 3379.72 -1.8 106027.1FOXO_KO.6 7.4348 0.507 100 2351.282 2350.277 0.8 74594

IPI:IPI00 1 1 5.30% 660 73437 7.7 U Tax_Id=10090 Gene_Symbol=Larp4 Putative uncharacterized protein FOXO_KO.1 4.3694 0.399 99.9 3640.751 3638.752 -2.2 31840.2

IPI:IPI00 2 3 5.30% 487 53925 9.5 U Tax_Id=10090 Gene_Symbol=Stau1 Double-stranded RNA-binding protein Staufen homolog 1 IPI:IPI00 2 3 5.30% 489 54166 9.5 U Tax_Id=10090 Gene_Symbol=Stau1 staufen (RNA binding protein) homolog 1 isoform 2 IPI:IPI00 2 3 5.40% 485 53747 9.6 U Tax_Id=10090 Gene_Symbol=Stau1 Staufen (RNA binding protein) homolog 1 IPI:IPI00 2 3 5.30% 495 54856 9.5 U Tax_Id=10090 Gene_Symbol=Stau1 staufen (RNA binding protein) homolog 1 isoform 1

FOXO_KO.1 3.0852 0.3068 99.9 1293.63 1293.632 -1.7 247613.5FOXO_KO.1 2.9672 0.2596 99.6 1665.852 1665.852 0.4 257953.6

IPI:IPI00 3 4 5.30% 437 50061 6.7 U Tax_Id=10090 Gene_Symbol=Eef1g Elongation factor 1-gamma IPI:IPI006 3 4 5.40% 423 48374 6.1 U Tax_Id=10090 Gene_Symbol=- hypothetical protein isoform 1 IPI:IPI004 3 4 5.40% 423 48330 6.5 U Tax_Id=10090 Gene_Symbol=Gm5525 hypothetical protein isoform 1

FOXO_KO.1 5.899 0.4523 100 2486.126 2485.122 0 35108FOXO_KO.1 4.4768 0.4131 100 2485.12 2485.122 -0.7 133520.1FOXO_KO.2 6.2304 0.5259 100 2358.031 2357.027 0.2 64032.8

IPI:IPI00 1 3 5.30% 323 37189 7.2 U Tax_Id=10090 Gene_Symbol=Akr1c14 Aldo-keto reductase family 1, member C14, isoform CRA_b * FOXO_KO.3 4.633 0.4236 100 1994.925 1993.925 -1.7 104154.7IPI:IPI00 1 2 5.30% 323 37048 8.3 U Tax_Id=10090 Gene_Symbol=Akr1c6 Estradiol 17 beta-dehydrogenase 5 IPI:IPI00 1 2 9.70% 175 20292 8.3 U Tax_Id=10090 Gene_Symbol=Akr1c6 20 kDa protein

FOXO_KO.3 4.8702 0.5826 100 2071.933 2071.935 -1.2 180789.6IPI:IPI00 1 1 5.30% 264 28532 7 U Tax_Id=10090 Gene_Symbol=Psmb5 Proteasome subunit beta type-5 IPI:IPI00 1 1 6.90% 203 22432 8.1 U Tax_Id=10090 Gene_Symbol=Psmb5 22 kDa protein IPI:IPI00 1 1 7.90% 177 18914 5.3 U Tax_Id=10090 Gene_Symbol=Psmb5 Putative uncharacterized protein

FOXO_KO.1 4.354 0.4445 100 1521.744 1521.745 -0.2 248258.8IPI:IPI007 1 3 5.30% 170 20066 11.6 U Tax_Id=10090 Gene_Symbol=Gm14449 similar to Mus musculus ribosomal protein L19 IPI:IPI00 1 3 7.40% 121 14776 11.2 U Tax_Id=10090 Gene_Symbol=LOC100045367 similar to ribosomal protein L19 IPI:IPI008 1 3 4.40% 205 24108 10.7 U Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L19

FOXO_KO_w 2.9389 0.3009 99.9 986.5261 986.5266 -0.5 63583.8IPI:IPI00 8 8 5.20% 2647 281191 6 U Tax_Id=10090 Gene_Symbol=Flna Isoform 1 of Filamin-A IPI:IPI00 8 8 5.20% 2647 281219 6 U Tax_Id=10090 Gene_Symbol=Flna Filamin, alpha IPI:IPI00 8 8 5.20% 2639 280498 6 U Tax_Id=10090 Gene_Symbol=Flna filamin, alpha IPI:IPI00 8 8 5.30% 2580 274310 6 U Tax_Id=10090 Gene_Symbol=Flna Filamin, alpha

FOXO_KO.1 2.6447 0.244 99.6 1172.592 1172.595 -2.3 267286.7FOXO_KO.1 5.68 0.4694 100 2314.095 2313.099 -3.2 130550.3FOXO_KO.1 5.1485 0.4752 100 1784.844 1784.845 -0.5 162000.3FOXO_KO.2 5.2947 0.3923 100 1938.018 1938.018 0.1 164713.5FOXO_KO.1 4.6645 0.4092 100 1501.756 1500.754 -0.7 219476.3FOXO_KO.1 3.513 0.3069 99.9 1904.902 1904.905 -1.7 168077.4FOXO_KO.1 3.6171 0.3557 99.9 2059.938 2057.935 -1.6 141976.9FOXO_KO.2 6.2665 0.514 100 2259.03 2258.028 -0.7 127394.2

IPI:IPI001 2 2 5.20% 960 111339 7.5 U Tax_Id=10090 Gene_Symbol=Opa1 Isoform 1 of Dynamin-like 120 kDa protein, mitochondrial

IPI:IPI00 2 2 9.40% 530 60124 8.8 U Tax_Id=10090 Gene_Symbol=Opa1 60 kDa protein IPI:IPI00 2 2 5.10% 978 113230 7.3 U Tax_Id=10090 Gene_Symbol=Opa1 113 kDa protein IPI:IPI00 2 2 7.20% 692 78934 8.3 U Tax_Id=10090 Gene_Symbol=Opa1 79 kDa protein IPI:IPI00 2 2 6.10% 825 95777 6.8 U Tax_Id=10090 Gene_Symbol=LOC100046998 similar to optic atrophy 1 IPI:IPI004 2 2 5.00% 997 115593 7.6 U Tax_Id=10090 Gene_Symbol=Opa1 Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial

FOXO_KO.5 3.7961 0.2675 99.7 3260.516 3259.51 0.8 38821.2FOXO_KO.3 3.8415 0.3231 99.9 2594.17 2593.169 -1 108146.3

IPI:IPI00 1 1 5.20% 687 76294 5.1 U Tax_Id=10090 Gene_Symbol=Akap8 A-kinase anchor protein 8 * FOXO_KO.2 5.0905 0.3755 100 3633.656 3631.652 -0.6 36530.5IPI:IPI004 1 1 5.20% 556 60449 6.2 U Tax_Id=10090 Gene_Symbol=Tcp1 Isoform 1 of T-complex protein 1 subunit alpha IPI:IPI008 1 1 5.70% 507 55459 6.4 U Tax_Id=10090 Gene_Symbol=Tcp1 Isoform 2 of T-complex protein 1 subunit alpha

FOXO_KO.4 4.5775 0.379 99.9 3100.657 3099.649 1.4 60948.8IPI:IPI00 2 2 5.20% 501 54588 7.7 U Tax_Id=10090 Gene_Symbol=Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 IPI:IPI00 2 2 5.20% 501 54468 7.8 U Tax_Id=10090 Gene_Symbol=Aldh1a1 Retinal dehydrogenase 1

FOXO_KO.2 4.0001 0.2286 99.6 2941.445 2939.446 -2.6 134290FOXO_KO.2 4.4712 0.2421 99.8 2812.354 2811.351 0 78456.9

IPI:IPI00 1 1 5.20% 388 43736 9.5 U Tax_Id=10090 Gene_Symbol=Lyar Cell growth-regulating nucleolar protein IPI:IPI00 1 1 10.50% 191 21746 8.6 U Tax_Id=10090 Gene_Symbol=Lyar 22 kDa protein IPI:IPI00 1 1 40.80% 49 5578 6.5 U Tax_Id=10090 Gene_Symbol=Lyar 6 kDa protein IPI:IPI00 1 1 20.20% 99 11228 8.5 U Tax_Id=10090 Gene_Symbol=Lyar 11 kDa protein IPI:IPI00 1 1 15.30% 131 14956 8.9 U Tax_Id=10090 Gene_Symbol=Lyar 15 kDa protein IPI:IPI00 1 1 10.50% 190 21616 8.7 U Tax_Id=10090 Gene_Symbol=Lyar 22 kDa protein

FOXO_KO.2 3.6248 0.339 99.9 2542.982 2541.978 0.4 175733.8IPI:IPI00 1 1 5.20% 329 37617 5.3 U Tax_Id=10090 Gene_Symbol=Uchl5 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 IPI:IPI00 1 1 5.20% 328 37488 5.4 U Tax_Id=10090 Gene_Symbol=Uchl5 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

FOXO_KO.3 3.4439 0.3282 99.9 1977.94 1977.944 -2.2 73799.5IPI:IPI00 1 1 5.20% 310 34577 6.5 U Tax_Id=10090 Gene_Symbol=Psmd14 26S proteasome non-ATPase regulatory subunit 14 * FOXO_KO.1 5.8458 0.3654 100 1831.917 1830.915 -0.9 146282.8IPI:IPI00 1 1 5.20% 229 24061 10.2 U Tax_Id=10090 Gene_Symbol=Gm12922 similar to hCG2016250 IPI:IPI00 1 1 15.80% 76 8497 8.5 U Tax_Id=10090 Gene_Symbol=Gm6549 similar to hCG2016250 IPI:IPI00 1 1 15.80% 76 8513 8 U Tax_Id=10090 Gene_Symbol=LOC671929 similar to hCG2016250 IPI:IPI006 1 1 6.50% 184 19965 10 U Tax_Id=10090 Gene_Symbol=Gm6549 similar to hCG2016250, isoform 3

FOXO_KO.1 3.2075 0.3515 100 1463.715 1463.717 -1.3 210517.6IPI:IPI00 1 1 5.20% 212 21267 11 U Tax_Id=10090 Gene_Symbol=Hist1h1c Histone H1.2 IPI:IPI00 1 1 5.00% 221 22099 11 U Tax_Id=10090 Gene_Symbol=Hist1h1d Histone H1.3 IPI:IPI00 1 1 5.30% 209 21669 11.6 U Tax_Id=10090 Gene_Symbol=Hist1h1t histone cluster 1, H1t IPI:IPI00 1 1 5.00% 219 21977 11.1 U Tax_Id=10090 Gene_Symbol=Hist1h1e Histone H1.4

FOXO_KO.9 2.6128 0.3808 100 1107.566 1107.568 -1.5 126392IPI:IPI00 3 5 5.10% 1445 161091 8.5 U Tax_Id=10090 Gene_Symbol=Ythdc2 Probable ATP-dependent RNA helicase YTHDC2 * FOXO_KO.3 4.7048 0.4033 100 2759.297 2758.294 -0.2 87027.4* FOXO_KO.4 4.5844 0.4937 100 3251.577 3249.577 -2.2 67989.1* FOXO_KO.4 5.4394 0.4884 100 2268.133 2267.13 -0.3 152104.6IPI:IPI00 3 3 5.10% 1082 120664 5 U Tax_Id=10090 Gene_Symbol=Supt5h Isoform 1 of Transcription elongation factor SPT5 * FOXO_KO.1 3.5845 0.4436 100 1689.741 1689.742 -0.8 185327.8

FOXO_KO.3 3.1159 0.2884 99.8 1969.938 1968.93 2.3 80043.3FOXO_KO.2 4.9544 0.3104 99.9 2627.219 2626.22 -1.8 88712.7

IPI:IPI00 2 3 5.10% 953 109318 5.1 U Tax_Id=10090 Gene_Symbol=Usp15 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 15 IPI:IPI00 2 3 5.10% 952 109013 5.1 U Tax_Id=10090 Gene_Symbol=Usp15 Ubiquitin carboxyl-terminal hydrolase

FOXO_KO.4 4.7857 0.2798 100 2299.172 2298.165 1.6 74908.2FOXO_KO.4 4.3481 0.4299 100 3552.69 3552.685 1.2 108123.9

IPI:IPI003 2 2 5.10% 917 102565 6.9 U Tax_Id=10090 Gene_Symbol=Ctnnd1 Isoform 3 of Catenin delta-1 IPI:IPI00 2 2 5.40% 878 98007 7.5 U Tax_Id=10090 Gene_Symbol=Ctnnd1 98 kDa protein IPI:IPI00 2 2 4.90% 961 107354 6.3 U Tax_Id=10090 Gene_Symbol=Ctnnd1 107 kDa protein IPI:IPI00 2 2 5.30% 892 99719 6.5 U Tax_Id=10090 Gene_Symbol=Ctnnd1 100 kDa protein IPI:IPI00 2 2 5.40% 866 96677 6.2 U Tax_Id=10090 Gene_Symbol=Ctnnd1 97 kDa protein IPI:IPI00 2 2 5.20% 907 101258 6.6 U Tax_Id=10090 Gene_Symbol=Ctnnd1 101 kDa protein IPI:IPI00 2 2 5.10% 913 102078 6.5 U Tax_Id=10090 Gene_Symbol=Ctnnd1 102 kDa protein IPI:IPI00 2 2 5.00% 940 104995 6.3 U Tax_Id=10090 Gene_Symbol=Ctnnd1 105 kDa protein IPI:IPI00 2 2 4.90% 967 108175 6.2 U Tax_Id=10090 Gene_Symbol=Ctnnd1 108 kDa protein IPI:IPI00 2 2 5.50% 860 95857 6.3 U Tax_Id=10090 Gene_Symbol=Ctnnd1 96 kDa protein IPI:IPI00 2 2 5.40% 868 96872 7.2 U Tax_Id=10090 Gene_Symbol=Ctnnd1 97 kDa protein IPI:IPI00 2 2 5.00% 932 104104 7 U Tax_Id=10090 Gene_Symbol=Ctnnd1 104 kDa protein IPI:IPI00 2 2 5.60% 839 93497 6.3 U Tax_Id=10090 Gene_Symbol=Ctnnd1 P120ctn IPI:IPI00 2 2 5.30% 884 98828 7.3 U Tax_Id=10090 Gene_Symbol=Ctnnd1 99 kDa protein IPI:IPI006 2 2 5.20% 911 101744 6.9 U Tax_Id=10090 Gene_Symbol=Ctnnd1 Isoform 2 of Catenin delta-1 IPI:IPI00 2 2 5.60% 837 93427 7 U Tax_Id=10090 Gene_Symbol=Ctnnd1 catenin, delta 1 isoform 3 IPI:IPI004 2 2 5.00% 938 104925 6.9 U Tax_Id=10090 Gene_Symbol=Ctnnd1 Isoform 1 of Catenin delta-1

FOXO_KO.3 3.9384 0.2365 99.7 3024.354 3023.352 -0.4 89288.3FOXO_KO.4 5.2033 0.2597 100 2476.215 2475.207 1.8 90982.4

IPI:IPI00 2 2 5.10% 838 95532 8.4 U Tax_Id=10090 Gene_Symbol=Ftsj3 Putative rRNA methyltransferase 3 * FOXO_KO.4 5.2253 0.3782 100 2628.239 2627.236 0 23764* FOXO_KO.3 5.224 0.4644 100 2346.027 2345.024 -0.4 152562.2IPI:IPI00 1 1 5.10% 547 62491 6.4 U Tax_Id=10090 Gene_Symbol=Riok2 Serine/threonine-protein kinase RIO2 * FOXO_KO.3 3.3621 0.3329 99.9 3005.387 3004.384 -0.3 74429.8IPI:IPI00 1 4 5.10% 455 52577 8.4 U Tax_Id=10090 Gene_Symbol=Ephx1 Epoxide hydrolase 1, microsomal, isoform CRA_c IPI:IPI00 1 4 17.70% 130 15544 6.4 U Tax_Id=10090 Gene_Symbol=Ephx1 16 kDa protein IPI:IPI00 1 4 5.20% 441 50970 8.2 U Tax_Id=10090 Gene_Symbol=Ephx1 51 kDa protein IPI:IPI00 1 4 5.10% 455 52576 8.7 U Tax_Id=10090 Gene_Symbol=Ephx1 Epoxide hydrolase 1

FOXO_KO.1 6.5114 0.4503 100 2801.376 2800.375 -0.7 64433.7IPI:IPI00 1 1 5.10% 447 50943 6 U Tax_Id=10090 Gene_Symbol=Bag5 BAG family molecular chaperone regulator 5 IPI:IPI00 1 1 4.50% 506 56927 6.4 U Tax_Id=10090 Gene_Symbol=LOC100047042 similar to BCL2-associated athanogene 5

FOXO_KO.6 5.4293 0.5129 100 2474.314 2473.309 0.8 85935.9IPI:IPI004 1 1 5.10% 433 46840 7 U Tax_Id=10090 Gene_Symbol=Suclg2 Isoform 1 of Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial IPI:IPI006 1 1 5.70% 384 41350 5.4 U Tax_Id=10090 Gene_Symbol=Suclg2 Isoform 2 of Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

FOXO_KO.1 3.7417 0.2343 99.6 2551.179 2550.178 -0.9 103342.5IPI:IPI00 1 1 5.10% 412 45965 6.8 U Tax_Id=10090 Gene_Symbol=Habp4 hyaluronic acid binding protein 4 * FOXO_KO.3 5.7863 0.4274 100 2574.185 2574.192 -2.8 40651.8IPI:IPI00 1 1 5.10% 336 37597 8.7 U Tax_Id=10090 Gene_Symbol=Mrpl1 39S ribosomal protein L1, mitochondrial IPI:IPI00 1 1 6.20% 276 31012 9 U Tax_Id=10090 Gene_Symbol=Mrpl1 mitochondrial ribosomal protein L1 isoform 2

FOXO_KO.1 5.672 0.4548 100 2111.931 2110.927 0.4 117272IPI:IPI00 1 3 5.10% 332 36499 7.7 U Tax_Id=10090 Gene_Symbol=Ldha L-lactate dehydrogenase A chain IPI:IPI00 1 3 6.20% 273 30014 9.1 U Tax_Id=10090 Gene_Symbol=Ldha 30 kDa protein IPI:IPI00 1 3 7.20% 237 26035 8.1 U Tax_Id=10090 Gene_Symbol=Ldha Ldha protein IPI:IPI00 1 3 4.70% 361 39758 8.4 U Tax_Id=10090 Gene_Symbol=Ldha lactate dehydrogenase A isoform 2

FOXO_KO.2 6.1962 0.3318 100 1981.082 1980.076 1.4 148059.4IPI:IPI00 1 1 5.10% 217 24307 8.4 U Tax_Id=10090 Gene_Symbol=Grpel1 GrpE protein homolog 1, mitochondrial

* FOXO_KO.3 2.7767 0.3072 99.8 1257.696 1257.694 1.6 269392.2IPI:IPI00 1 2 5.00% 378 42599 5.7 U Tax_Id=10090 Gene_Symbol=Serpinb6a Serpin B6 IPI:IPI00 1 2 4.80% 399 44774 6.4 U Tax_Id=10090 Gene_Symbol=Serpinb6a serine (or cysteine) proteinase inhibitor, clade B, member 6a isoform a IPI:IPI00 1 2 12.20% 156 17025 5.3 U Tax_Id=10090 Gene_Symbol=Serpinb6a Putative uncharacterized protein

FOXO_KO.2 7.1586 0.5786 100 2264.005 2263.004 -0.7 75833IPI:IPI00 1 1 5.00% 298 33720 4.7 U Tax_Id=10090 Gene_Symbol=Ssr1 Translocon-associated protein alpha, muscle specific isoform IPI:IPI00 1 1 5.20% 286 32065 4.5 U Tax_Id=10090 Gene_Symbol=Ssr1 Translocon-associated protein subunit alpha IPI:IPI006 1 1 5.50% 274 31222 4.5 U Tax_Id=10090 Gene_Symbol=LOC636537 similar to translocon-associated protein alpha, muscle specific

FOXO_KO.3 4.2796 0.4359 100 1686.8 1685.802 -3 147627.8IPI:IPI00 1 1 5.00% 199 22263 8.1 U Tax_Id=10090 Gene_Symbol=Gm7204 similar to MSP23 isoform 2 IPI:IPI008 1 1 3.30% 299 33776 8.5 U Tax_Id=10090 Gene_Symbol=Gm7204 similar to MSP23 isoform 1 IPI:IPI00 1 1 5.70% 176 19483 6.8 U Tax_Id=10090 Gene_Symbol=Prdx1 Peroxiredoxin 1 IPI:IPI00 1 1 5.90% 170 18927 7.3 U Tax_Id=10090 Gene_Symbol=Prdx1 Peroxiredoxin 1

FOXO_KO.1 3.3992 0.3591 100 1196.63 1196.631 -1.1 381595.5IPI:IPI007 10 13 4.90% 2607 283412 12.1 U Tax_Id=10090 Gene_Symbol=Srrm2 Isoform 2 of Serine/arginine repetitive matrix protein 2

FOXO_KO.1 6.4949 0.4869 100 2506.259 2505.258 -0.9 48679.2FOXO_KO.1 4.0731 0.2917 99.9 2505.254 2505.258 -1.7 171995.1FOXO_KO.1 5.5424 0.4682 100 2640.138 2638.138 -2.5 181300FOXO_KO.1 5.4483 0.4632 100 2638.137 2638.138 -0.6 136576.3FOXO_KO.1 4.3409 0.4102 100 2719.107 2718.105 -0.4 121891.7FOXO_KO.1 3.7892 0.3699 100 2015.949 2014.948 -1.1 81585.4FOXO_KO.2 3.5827 0.3518 100 1819.879 1818.879 -1.7 113795.2FOXO_KO.2 5.1176 0.615 100 2224.989 2224.007 -9.7 74684.1FOXO_KO_w 3.6421 0.2992 99.9 1733.814 1732.813 -1.2 28994.8FOXO_KO.1 3.4088 0.2964 99.9 1612.72 1610.718 -2.6 217837.5

IPI:IPI00 2 2 4.90% 716 80212 7.2 U Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 2 of Dynamin-1-like protein IPI:IPI00 2 2 4.90% 712 79533 7.1 U Tax_Id=10090 Gene_Symbol=Dnm1l dynamin 1-like isoform a IPI:IPI00 2 2 5.00% 699 78011 6.8 U Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 3 of Dynamin-1-like protein IPI:IPI00 2 2 4.70% 742 82658 7.1 U Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 1 of Dynamin-1-like protein

FOXO_KO.3 4.1147 0.1407 99.6 2301.067 2300.068 -1.8 102786.8FOXO_KO.4 5.9341 0.4626 100 1923.901 1922.901 -1.6 201914.2

IPI:IPI00 1 1 4.90% 573 64761 7.2 U Tax_Id=10090 Gene_Symbol=Acsm1 Isoform 1 of Acyl-coenzyme A synthetase ACSM1, mitochondrial IPI:IPI00 1 1 16.10% 174 19984 7.8 U Tax_Id=10090 Gene_Symbol=Acsm1 20 kDa protein IPI:IPI00 1 1 5.10% 546 61848 6.8 U Tax_Id=10090 Gene_Symbol=Acsm1 Isoform 2 of Acyl-coenzyme A synthetase ACSM1, mitochondrial

FOXO_KO.4 4.439 0.4636 100 3390.405 3388.401 -1 60141IPI:IPI00 2 3 4.90% 553 59753 9.2 U Tax_Id=10090 Gene_Symbol=Atp5a1 ATP synthase subunit alpha, mitochondrial IPI:IPI00 2 3 5.40% 503 54595 8.2 U Tax_Id=10090 Gene_Symbol=Atp5a1 55 kDa protein

FOXO_KO.2 3.6583 0.2805 99.9 1624.891 1624.89 0.4 150771.9FOXO_KO.1 3.2404 0.3103 99.9 1287.693 1287.694 -0.8 276195.9

IPI:IPI00 2 3 4.90% 493 54712 5.7 U Tax_Id=10090 Gene_Symbol=Prpf31 Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp31 FOXO_KO.3 5.71 0.5036 100 2673.224 2672.219 0.9 50361.9FOXO_KO.3 4.8559 0.4443 100 2672.215 2672.219 -1.4 183369.3

IPI:IPI00 1 2 4.90% 446 49234 4.8 U Tax_Id=10090 Gene_Symbol=Grwd1 Glutamate-rich WD repeat-containing protein 1 IPI:IPI00 1 2 22.70% 97 10641 4.9 U Tax_Id=10090 Gene_Symbol=Grwd1 11 kDa protein IPI:IPI00 1 2 5.30% 416 45944 4.8 U Tax_Id=10090 Gene_Symbol=Grwd1 46 kDa protein

FOXO_KO.3 5.1778 0.5979 100 2533.192 2533.191 0.3 244385.5IPI:IPI00 1 2 4.90% 410 46867 7.1 U Tax_Id=10090 Gene_Symbol=Rnmt Isoform 3 of mRNA cap guanine-N7 methyltransferase IPI:IPI00 1 2 16.10% 124 13542 4.8 U Tax_Id=10090 Gene_Symbol=Rnmt 14 kDa protein

IPI:IPI00 1 2 9.80% 205 22890 6 U Tax_Id=10090 Gene_Symbol=Rnmt 23 kDa protein IPI:IPI00 1 2 5.40% 369 41908 5.5 U Tax_Id=10090 Gene_Symbol=Rnmt Isoform 2 of mRNA cap guanine-N7 methyltransferase IPI:IPI00 1 2 4.30% 465 53291 6.5 U Tax_Id=10090 Gene_Symbol=Rnmt Isoform 1 of mRNA cap guanine-N7 methyltransferase

FOXO_KO.1 6.4869 0.487 100 2258.007 2258.01 -1 48374.1IPI:IPI00 1 1 4.90% 304 34909 6 U Tax_Id=10090 Gene_Symbol=Stub1 STIP1 homology and U box-containing protein 1 * FOXO_KO.3 5.4987 0.4888 100 1820.773 1820.772 0.4 161258.4IPI:IPI001 1 1 4.90% 288 33666 11.2 U Tax_Id=10090 Gene_Symbol=Tra2b Isoform 1 of Transformer-2 protein homolog beta * FOXO_KO.3 5.2857 0.3852 100 1622.76 1621.753 2.1 226814.9IPI:IPI00 6 7 4.80% 2114 238832 8.6 U Tax_Id=10090 Gene_Symbol=Myo9b Isoform 1 of Myosin-IXb IPI:IPI00 6 7 5.20% 1975 223924 8.4 U Tax_Id=10090 Gene_Symbol=Myo9b myosin IXb isoform 2 IPI:IPI00 6 7 4.80% 2128 240314 8.6 U Tax_Id=10090 Gene_Symbol=Myo9b myosin IXb isoform 1 IPI:IPI00 6 7 5.20% 1961 222442 8.4 U Tax_Id=10090 Gene_Symbol=Myo9b Isoform 3 of Myosin-IXb IPI:IPI00 6 7 4.80% 2143 242236 8.4 U Tax_Id=10090 Gene_Symbol=Myo9b Isoform 2 of Myosin-IXb

FOXO_KO.1 3.7548 0.4328 100 1969.877 1969.889 -6.1 50124.5FOXO_KO.1 3.2693 0.3892 100 1701.792 1700.789 -0.2 115959.9FOXO_KO.1 4.6081 0.5768 100 1809.821 1808.819 -0.4 153030FOXO_KO.5 4.3268 0.2645 99.9 2440.259 2438.256 -1.6 63167.9FOXO_KO.6 6.1442 0.5238 100 2124.099 2124.097 0.8 94132FOXO_KO.3 4.2225 0.3774 99.9 3501.803 3500.802 -0.6 138144.7

IPI:IPI00 4 4 4.80% 1112 117335 7.1 U Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 5 of Ubiquitin-associated protein 2-like IPI:IPI00 4 4 5.40% 983 103946 7 U Tax_Id=10090 Gene_Symbol=Ubap2l Nice-4 protein homolog isoform 6 IPI:IPI00 4 4 5.00% 1067 112421 6.6 U Tax_Id=10090 Gene_Symbol=Ubap2l Nice-4 protein homolog isoform 2 IPI:IPI00 4 4 4.80% 1107 116799 7.1 U Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 1 of Ubiquitin-associated protein 2-like IPI:IPI007 4 4 5.00% 1068 112549 6.6 U Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 3 of Ubiquitin-associated protein 2-like IPI:IPI00 4 4 5.20% 1014 107242 7.1 U Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 2 of Ubiquitin-associated protein 2-like IPI:IPI00 4 4 4.80% 1105 116903 6.5 U Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 4 of Ubiquitin-associated protein 2-like

FOXO_KO.1 6.0739 0.4688 100 1863.827 1862.823 0.5 130080.8FOXO_KO.1 2.7177 0.2939 99.6 1862.821 1862.823 -1 246778.4FOXO_KO.1 6.7402 0.5351 100 2129.913 2128.914 -2 77639.9FOXO_KO.2 5.0021 0.497 100 2240.945 2240.947 -0.8 143829.1

IPI:IPI00 1 1 4.80% 521 57773 4.9 U Tax_Id=10090 Gene_Symbol=Kpna3 Importin subunit alpha-3 * FOXO_KO.5 4.4511 0.3751 99.9 2678.344 2676.311 10 47832.5IPI:IPI00 1 2 4.80% 399 44591 5 U Tax_Id=10090 Gene_Symbol=Ddi2 Protein DDI1 homolog 2 * FOXO_KO.2 4.5852 0.251 99.9 2198.1 2197.098 -0.6 159551.5IPI:IPI00 1 1 4.80% 354 40538 5.7 U Tax_Id=10090 Gene_Symbol=Gnai3 Guanine nucleotide-binding protein G(k) subunit alpha * FOXO_KO.2 4.9543 0.5148 100 2079.923 2078.93 -5 92529.1IPI:IPI00 1 1 4.80% 334 37547 6.8 U Tax_Id=10090 Gene_Symbol=Ctsl Cathepsin L1 * FOXO_KO.1 3.6979 0.4326 100 1787.762 1787.761 0.7 109684.6IPI:IPI00 3 6 4.70% 1392 156614 6.8 U Tax_Id=10090 Gene_Symbol=Lrpprc Leucine-rich PPR motif-containing protein, mitochondrial IPI:IPI00 3 6 5.10% 1306 147422 6.4 U Tax_Id=10090 Gene_Symbol=Lrpprc 147 kDa protein

FOXO_KO.5 5.1213 0.3476 99.9 3437.611 3436.607 0.1 54896.7FOXO_KO.1 4.2281 0.3692 100 1624.788 1624.791 -2 219254.1FOXO_KO.3 4.169 0.3944 100 2266.111 2265.111 -1.7 102195.1

IPI:IPI00 2 2 4.70% 1074 116859 9 U Tax_Id=10090 Gene_Symbol=Zfr Zinc finger RNA-binding protein * FOXO_KO.2 3.4806 0.2869 99.7 3365.629 3364.629 -1.1 31419.4

FOXO_KO.1 3.5404 0.2324 99.8 1930.921 1929.922 -2.4 138345.8IPI:IPI004 2 2 4.70% 888 98310 7.2 U Tax_Id=10090 Gene_Symbol=Supt5h Isoform 2 of Transcription elongation factor SPT5

FOXO_KO.3 3.1159 0.2884 99.8 1969.938 1968.93 2.3 80043.3

FOXO_KO.2 4.9544 0.3104 99.9 2627.219 2626.22 -1.8 88712.7IPI:IPI00 2 2 4.70% 878 98199 5.6 U Tax_Id=10090 Gene_Symbol=Sf3b2 splicing factor 3b, subunit 2 * FOXO_KO.2 5.7281 0.3879 100 2235.095 2234.09 0.7 65181.1* FOXO_KO.1 5.7591 0.5254 100 2392.104 2390.093 1.8 49786.2IPI:IPI00 2 2 4.70% 727 79777 5.7 U Tax_Id=10090 Gene_Symbol=Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 precursor * FOXO_KO.3 4.7043 0.4876 100 1631.848 1630.847 -1.7 165352.6

FOXO_KO.2 6.4697 0.5151 100 2165.958 2163.972 -9.3 137322.7IPI:IPI00 1 2 4.70% 590 64062 8.2 U Tax_Id=10090 Gene_Symbol=Rbm47 Isoform 1 of RNA-binding protein 47 IPI:IPI00 1 2 5.40% 521 56869 6.9 U Tax_Id=10090 Gene_Symbol=Rbm47 Isoform 2 of RNA-binding protein 47

FOXO_KO.3 4.6268 0.3718 99.9 3264.594 3264.588 1.6 98045.3IPI:IPI00 1 2 4.70% 424 44356 8.6 U Tax_Id=10090 Gene_Symbol=Sf3b4 Splicing factor 3B subunit 4 IPI:IPI006 1 2 4.70% 425 44626 8.2 U Tax_Id=10090 Gene_Symbol=Gm7935 similar to Splicing factor 3b, subunit 4

FOXO_KO.3 7.6776 0.5627 100 2188.107 2186.097 1.5 166967.9IPI:IPI001 1 2 4.70% 360 38271 10.9 U Tax_Id=10090 Gene_Symbol=Ybx2 Isoform 1 of Y-box-binding protein 2 IPI:IPI00 1 2 4.70% 359 38080 10.8 U Tax_Id=10090 Gene_Symbol=Ybx2 Y box protein 2 IPI:IPI00 1 2 5.60% 302 33732 10.3 U Tax_Id=10090 Gene_Symbol=LOC100045903 similar to Y box protein 2 IPI:IPI005 1 2 6.00% 282 31465 11.3 U Tax_Id=10090 Gene_Symbol=Ybx2 Isoform 2 of Y-box-binding protein 2

FOXO_KO.2 6.2205 0.4505 100 1796.825 1795.823 -1 263572.8IPI:IPI00 1 1 4.70% 299 32192 5.7 U Tax_Id=10090 Gene_Symbol=Tpi1 triosephosphate isomerase 1 * FOXO_KO.2 3.6654 0.2816 99.9 1539.788 1539.791 -2.5 418720.9IPI:IPI00 2 2 4.70% 254 28176 8.9 U Tax_Id=10090 Gene_Symbol=LOC677576 similar to 3-methylcrotonyl-CoA carboxylase alpha subunit

FOXO_KO.1 4.4132 0.3511 100 1412.7 1410.693 0.2 281373.8FOXO_KO.1 3.3229 0.375 100 1282.596 1282.598 -1.8 418736.2

IPI:IPI00 2 2 4.60% 852 94526 7.2 U Tax_Id=10090 Gene_Symbol=Lonp2 Isoform 1 of Peroxisomal Lon protease homolog 2 IPI:IPI00 2 2 5.90% 659 73989 7.3 U Tax_Id=10090 Gene_Symbol=Lonp2 Isoform 2 of Peroxisomal Lon protease homolog 2

FOXO_KO.2 3.5783 0.2471 99.8 1742.83 1742.834 -2.3 133937.3FOXO_KO.2 4.489 0.3055 99.9 2909.33 2909.325 2 57764.1

IPI:IPI00 2 2 4.60% 767 87265 9.2 U Tax_Id=10090 Gene_Symbol=Utp14a Isoform 1 of U3 small nucleolar RNA-associated protein 14 homolog A * FOXO_KO.1 3.879 0.3628 100 1456.749 1456.753 -2.8 147159.6* FOXO_KO.3 4.0452 0.4546 100 2315.16 2315.161 -0.6 115018.7IPI:IPI00 1 1 4.60% 587 64679 6.7 U Tax_Id=10090 Gene_Symbol=Gckr Glucokinase regulatory protein * FOXO_KO.2 4.5118 0.449 100 3073.483 3072.484 -1.2 102675.7IPI:IPI00 1 1 4.60% 523 57302 6.6 U Tax_Id=10090 Gene_Symbol=Prpf19 Isoform 2 of Pre-mRNA-processing factor 19 IPI:IPI00 1 1 4.80% 504 55239 6.6 U Tax_Id=10090 Gene_Symbol=Prpf19 Isoform 1 of Pre-mRNA-processing factor 19

FOXO_KO.2 2.9048 0.2527 99.6 2716.335 2714.352 -8.5 12376.2IPI:IPI003 1 1 4.60% 505 57188 9.4 U Tax_Id=10090 Gene_Symbol=Gnl3 Isoform 2 of Guanine nucleotide-binding protein-like 3

FOXO_KO.9 3.6924 0.2186 99.5 2602.206 2602.211 -2 147894.8IPI:IPI001 1 1 4.60% 500 53663 8 U Tax_Id=10090 Gene_Symbol=Gsr Isoform Mitochondrial of Glutathione reductase, mitochondrial IPI:IPI007 1 1 4.90% 474 51074 7.4 U Tax_Id=10090 Gene_Symbol=Gsr Isoform Cytoplasmic of Glutathione reductase, mitochondrial

FOXO_KO.3 5.0517 0.4807 100 2568.213 2568.213 0 17298.2IPI:IPI004 1 1 4.60% 458 51506 4.7 U Tax_Id=10090 Gene_Symbol=Aatf Isoform 3 of Protein AATF

FOXO_KO.1 3.9069 0.2737 99.9 2423.173 2422.173 -1.3 234692.2IPI:IPI004 2 2 4.60% 452 50133 5.2 U Tax_Id=10090 Gene_Symbol=Krt42 Keratin, type I cytoskeletal 42

FOXO_KO.1 4.3926 0.3543 100 1301.656 1301.658 -2 249696.4FOXO_KO.2 2.8754 0.402 100 1172.524 1172.526 -1.7 175608.3

IPI:IPI00 1 1 4.60% 458 50121 4.6 U Tax_Id=10090 Gene_Symbol=Shq1 Isoform 2 of Protein SHQ1 homolog IPI:IPI00 1 1 3.70% 569 63458 4.8 U Tax_Id=10090 Gene_Symbol=Shq1 Isoform 1 of Protein SHQ1 homolog

FOXO_KO.4 4.533 0.3418 99.9 2542.184 2541.182 -0.6 108701

IPI:IPI00 1 2 4.60% 433 48428 4.9 U Tax_Id=10090 Gene_Symbol=Dbnl Isoform 2 of Drebrin-like protein IPI:IPI00 1 2 4.60% 432 48341 4.9 U Tax_Id=10090 Gene_Symbol=Dbnl Isoform 3 of Drebrin-like protein IPI:IPI00 1 2 4.60% 436 48700 4.9 U Tax_Id=10090 Gene_Symbol=Dbnl Isoform 1 of Drebrin-like protein

FOXO_KO.3 5.3302 0.6 100 1987.986 1987.982 2.3 89562.8IPI:IPI00 1 1 4.60% 439 48355 6.6 U Tax_Id=10090 Gene_Symbol=Oat Ornithine aminotransferase, mitochondrial * FOXO_KO.3 4.115 0.4899 100 2155.114 2155.113 0.3 113282.6IPI:IPI00 1 1 4.60% 347 39238 5.2 U Tax_Id=10090 Gene_Symbol=Polr1c Polr1c protein IPI:IPI00 1 1 5.90% 269 30166 4.8 U Tax_Id=10090 Gene_Symbol=Polr1c 30 kDa protein IPI:IPI00 1 1 6.20% 260 29383 5.8 U Tax_Id=10090 Gene_Symbol=Polr1c 29 kDa protein IPI:IPI008 1 1 4.60% 346 39076 5.4 U Tax_Id=10090 Gene_Symbol=Polr1c DNA-directed RNA polymerases I and III subunit RPAC1

FOXO_KO.1 6.1396 0.4946 100 1866.853 1865.851 -1 87983.1IPI:IPI00 1 5 4.60% 325 36461 5.6 U Tax_Id=10090 Gene_Symbol=Eif3i Eukaryotic translation initiation factor 3 subunit I * FOXO_KO.3 4.9485 0.4977 100 1982.866 1981.864 -1.1 86761.4IPI:IPI00 1 2 4.60% 324 36212 8.4 U Tax_Id=10090 Gene_Symbol=Tor1aip1 Putative uncharacterized protein

FOXO_KO.2 4.8052 0.58 100 1772.783 1771.781 -0.9 137579.9IPI:IPI00 1 1 4.60% 282 31814 8.7 U Tax_Id=10090 Gene_Symbol=Sdhb Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial * FOXO_KO.1 2.4288 0.2987 99.5 1700.742 1699.738 0.3 212403.2IPI:IPI003 2 3 4.50% 985 111944 7.3 U Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 1 of Rho guanine nucleotide exchange factor 2 IPI:IPI00 2 3 4.50% 977 111027 7.4 U Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 4 of Rho guanine nucleotide exchange factor 2 IPI:IPI009 2 3 4.60% 956 108498 6.8 U Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 5 of Rho guanine nucleotide exchange factor 2

FOXO_KO.2 4.1323 0.3809 100 1767.876 1767.876 0.1 163622.1FOXO_KO.5 4.2445 0.4017 99.9 3271.789 3270.784 0.3 41948

IPI:IPI00 2 2 4.50% 860 98769 7.6 U Tax_Id=10090 Gene_Symbol=Nop14 probable nucleolar complex protein 14 FOXO_KO.2 3.9676 0.3691 100 1593.656 1593.659 -2.3 214048.2

* FOXO_KO.5 3.5337 0.2416 99.5 2897.423 2896.418 0.4 26673.8IPI:IPI00 2 2 4.50% 781 85471 5.9 U Tax_Id=10090 Gene_Symbol=Ctnnb1 Catenin beta-1 IPI:IPI00 2 2 4.50% 781 85497 5.9 U Tax_Id=10090 Gene_Symbol=Ctnnb1 Putative uncharacterized protein

FOXO_KO.3 5.321 0.3777 100 3634.841 3633.843 -1.5 78691.7FOXO_KO.3 5.5722 0.3981 100 3635.848 3633.843 -0.4 205892.1

IPI:IPI003 2 3 4.50% 643 69971 6.8 U Tax_Id=10090 Gene_Symbol=Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 isoform 1 IPI:IPI00 2 3 6.10% 478 53495 6.6 U Tax_Id=10090 Gene_Symbol=Ahcyl2 Adenosylhomocysteinase (Fragment) IPI:IPI00 2 3 12.20% 238 26533 8.6 U Tax_Id=10090 Gene_Symbol=Ahcyl2 27 kDa protein IPI:IPI00 2 3 5.70% 508 56944 7.1 U Tax_Id=10090 Gene_Symbol=Ahcyl2 57 kDa protein IPI:IPI00 2 3 4.50% 642 69843 6.8 U Tax_Id=10090 Gene_Symbol=Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 isoform 2 IPI:IPI007 2 3 5.70% 508 56757 8.1 U Tax_Id=10090 Gene_Symbol=Ahcyl2 Isoform 2 of Putative adenosylhomocysteinase 3

FOXO_KO.3 4.1107 0.3332 100 1844.921 1843.929 -6.1 77601.9FOXO_KO.3 4.9599 0.5127 100 1715.684 1714.68 0 220990.6

IPI:IPI00 1 1 4.50% 536 61167 7.4 U Tax_Id=10090 Gene_Symbol=Sars Seryl-aminoacyl-tRNA synthetase, isoform CRA_b IPI:IPI00 1 1 4.70% 512 58389 6.3 U Tax_Id=10090 Gene_Symbol=Sars Seryl-tRNA synthetase, cytoplasmic

FOXO_KO.1 4.8217 0.3932 100 2661.309 2661.312 -1 126390.5IPI:IPI00 1 1 4.50% 533 60720 9.1 U Tax_Id=10090 Gene_Symbol=Cyp27a1 Sterol 26-hydroxylase, mitochondrial * FOXO_KO.4 4.5328 0.2584 99.9 2708.426 2707.419 1.2 125370.5IPI:IPI00 1 1 4.50% 507 55663 4.8 U Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 1 of TOM1-like protein 2 IPI:IPI006 1 1 4.70% 487 53383 4.9 U Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 2 of TOM1-like protein 2 IPI:IPI00 1 1 5.20% 440 48408 5.1 U Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 3 of TOM1-like protein 2 IPI:IPI00 1 1 8.80% 261 28454 4.6 U Tax_Id=10090 Gene_Symbol=Tom1l2 Target of myb1-like 2 IPI:IPI00 1 1 5.00% 457 50070 4.7 U Tax_Id=10090 Gene_Symbol=Tom1l2 Target of myb1-like 2 IPI:IPI00 1 1 5.00% 462 50573 4.8 U Tax_Id=10090 Gene_Symbol=Tom1l2 Target of myb1-like 2

IPI:IPI00 1 1 5.10% 450 49439 5.1 U Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 4 of TOM1-like protein 2 FOXO_KO.3 3.2388 0.2966 99.7 2699.35 2698.332 5.5 83506

IPI:IPI00 1 1 4.50% 463 53723 7.5 U Tax_Id=10090 Gene_Symbol=Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 IPI:IPI00 1 1 4.50% 463 53737 7.5 U Tax_Id=10090 Gene_Symbol=Ifit1 Putative uncharacterized protein

FOXO_KO.3 4.7983 0.3855 100 2526.278 2525.274 0.2 129553.3IPI:IPI003 1 2 4.50% 449 50052 5.1 U Tax_Id=10090 Gene_Symbol=Tuba8 Tubulin alpha-8 chain IPI:IPI00 1 2 5.10% 395 44049 6.1 U Tax_Id=10090 Gene_Symbol=Tuba3b;Tuba3a Putative uncharacterized protein

FOXO_KO.2 6.2379 0.5428 100 2332.023 2330.018 -0.8 163114IPI:IPI00 1 1 4.50% 443 49715 8.5 U Tax_Id=10090 Gene_Symbol=Cpox Coproporphyrinogen-III oxidase, mitochondrial * FOXO_KO.3 2.9121 0.279 99.5 2201.054 2200.056 -2.3 217551.6IPI:IPI00 1 1 4.50% 311 35867 5.7 U Tax_Id=10090 Gene_Symbol=Apoe Apolipoprotein E * FOXO_KO.1 2.9912 0.3655 99.9 1599.784 1599.786 -1.3 285159.1IPI:IPI001 1 2 4.50% 312 34742 9.5 U Tax_Id=10090 Gene_Symbol=Hsd17b12 Isoform 1 of Estradiol 17-beta-dehydrogenase 12 * FOXO_KO.3 5.5973 0.5086 100 1616.795 1614.79 -0.8 467647IPI:IPI00 2 3 4.40% 1122 128837 6.2 U Tax_Id=10090 Gene_Symbol=Rbm6 Rbm6 protein * FOXO_KO.7 2.5253 0.3054 99.5 1899.784 1897.785 -4.1 99207.2

FOXO_KO.2 5.996 0.4264 100 3407.537 3405.535 -1.5 107932.8IPI:IPI004 2 3 4.40% 1125 117429 5 U Tax_Id=10090 Gene_Symbol=Mtap4 Isoform 1 of Microtubule-associated protein 4 IPI:IPI008 2 3 4.40% 1125 117442 5 U Tax_Id=10090 Gene_Symbol=Mtap4 microtubule-associated protein 4 IPI:IPI004 2 3 4.50% 1087 113742 4.9 U Tax_Id=10090 Gene_Symbol=Mtap4 Isoform 3 of Microtubule-associated protein 4

FOXO_KO.3 5.3213 0.436 100 2344.08 2342.075 -0.7 65491.2FOXO_KO.3 4.8319 0.3645 99.9 3086.559 3086.564 -1.3 81167.4

IPI:IPI001 1 1 4.40% 637 71079 8 U Tax_Id=10090 Gene_Symbol=Dus3l Isoform 1 of tRNA-dihydrouridine synthase 3-like IPI:IPI007 1 1 6.60% 426 46697 7.6 U Tax_Id=10090 Gene_Symbol=Dus3l Isoform 2 of tRNA-dihydrouridine synthase 3-like

FOXO_KO.1 3.6789 0.431 99.9 3046.353 3045.353 -1.3 74671.8IPI:IPI00 1 1 4.40% 544 59652 7.8 U Tax_Id=10090 Gene_Symbol=Cct7 T-complex protein 1 subunit eta * FOXO_KO.3 6.2396 0.5649 100 2892.447 2891.446 -0.8 97458IPI:IPI00 2 3 4.40% 520 57569 6 U Tax_Id=10090 Gene_Symbol=Hmgcs1;LOC100040592 Hydroxymethylglutaryl-CoA synthase, cytoplasmic

FOXO_KO.1 3.2874 0.4323 100 1217.661 1217.662 -1.1 298965.8* FOXO_KO.1 3.9098 0.2501 99.9 1530.716 1529.712 0.2 161632.1IPI:IPI00 1 1 4.40% 472 52610 6.2 U Tax_Id=10090 Gene_Symbol=Selenbp2 Selenium-binding protein 2 IPI:IPI00 1 1 4.40% 472 52514 6.3 U Tax_Id=10090 Gene_Symbol=LOC100044204;Selenbp1 Selenium-binding protein 1

FOXO_KO.6 5.3114 0.4283 100 2386.222 2385.219 -0.4 97454.3IPI:IPI00 2 3 4.40% 453 48235 9.3 U Tax_Id=10090 Gene_Symbol=Uqcrc2 Cytochrome b-c1 complex subunit 2, mitochondrial * FOXO_KO.6 3.5178 0.2714 99.9 2339.205 2338.2 0.8 25491* FOXO_KO.6 3.6157 0.4607 100 2339.201 2338.2 -1.1 58163.2IPI:IPI00 1 1 4.40% 434 46375 8.4 U Tax_Id=10090 Gene_Symbol=Rcc1 Regulator of chromosome condensation 1 IPI:IPI00 1 1 4.50% 421 44931 8.1 U Tax_Id=10090 Gene_Symbol=Rcc1 Regulator of chromosome condensation

FOXO_KO.1 4.6801 0.3648 100 2063.005 2062.001 0.4 138220.6IPI:IPI00 1 2 4.40% 389 46367 8.5 U Tax_Id=10090 Gene_Symbol=Rdx radixin isoform b IPI:IPI00 1 2 2.90% 583 68543 6.2 U Tax_Id=10090 Gene_Symbol=Rdx radixin isoform a IPI:IPI003 1 2 2.90% 583 68601 6.1 U Tax_Id=10090 Gene_Symbol=Rdx Radixin

FOXO_KO.4 5.8065 0.3243 100 2081.035 2080.023 4.3 72262.8IPI:IPI00 1 1 4.40% 410 44954 7.1 U Tax_Id=10090 Gene_Symbol=Ctsd Cathepsin D IPI:IPI00 1 1 6.50% 278 29955 6.7 U Tax_Id=10090 Gene_Symbol=Ctsd Protein IPI:IPI00 1 1 4.40% 410 44924 7.1 U Tax_Id=10090 Gene_Symbol=Ctsd Putative uncharacterized protein IPI:IPI00 1 1 4.00% 445 48374 7.3 U Tax_Id=10090 Gene_Symbol=Ctsd Putative uncharacterized protein

FOXO_KO.1 4.9197 0.5144 100 1787.812 1787.812 0.1 113125.1

IPI:IPI00 2 2 4.40% 386 43516 5.1 U Tax_Id=10090 Gene_Symbol=G3bp1 Putative uncharacterized protein FOXO_KO.1 4.1566 0.3817 100 1804.812 1804.811 0.1 156648.9FOXO_KO.1 4.2532 0.4347 100 1804.81 1804.811 -0.8 137504.4

IPI:IPI00 1 3 4.40% 383 42287 8.4 U Tax_Id=10090 Gene_Symbol=Fn1 Fn1 protein FOXO_KO.1 5.2374 0.5019 100 2074.85 2073.853 -3.1 102943.1

IPI:IPI00 1 1 4.40% 361 41526 6.5 U Tax_Id=10090 Gene_Symbol=Sept2 Septin-2 IPI:IPI00 1 1 5.00% 321 36978 6.1 U Tax_Id=10090 Gene_Symbol=Sept2 septin 2 b

FOXO_KO.1 3.8549 0.2914 99.9 1946.99 1945.99 -1.5 182490.9IPI:IPI006 1 1 4.40% 321 35531 5.4 U Tax_Id=10090 Gene_Symbol=Cep170 Isoform 3 of Centrosomal protein of 170 kDa

FOXO_KO.1 3.5927 0.4356 100 1617.67 1616.671 -2.5 206511.3IPI:IPI00 1 1 4.40% 298 32931 9.7 U Tax_Id=10090 Gene_Symbol=Slc25a5 ADP/ATP translocase 2 IPI:IPI006 1 1 4.40% 296 32844 9.5 U Tax_Id=10090 Gene_Symbol=- similar to adenine nucleotide translocase isoform 1 IPI:IPI004 1 1 4.40% 296 32876 9.5 U Tax_Id=10090 Gene_Symbol=Gm5529 similar to adenine nucleotide translocase

FOXO_KO.2 4.2647 0.2941 100 1219.669 1219.668 0.6 224860.4IPI:IPI00 1 1 4.40% 249 28745 10.7 U Tax_Id=10090 Gene_Symbol=Gm16406 similar to ribosomal protein S6

FOXO_KO.1 4.1138 0.3652 100 1280.647 1280.648 -0.6 33738IPI:IPI00 6 7 4.30% 1344 161936 6.8 U Tax_Id=10090 Gene_Symbol=Eif3a Eukaryotic translation initiation factor 3 subunit A * FOXO_KO.2 4.0083 0.2697 99.9 2795.441 2794.437 0.1 121191.5* FOXO_KO.3 6.6571 0.4478 100 2468.203 2467.195 2 51366.2* FOXO_KO.3 5.1527 0.3214 99.9 2468.198 2467.195 0 226794.6* FOXO_KO.4 5.7457 0.4748 100 2123.002 2120.994 0.6 145102.1* FOXO_KO.1 4.462 0.445 100 1834.826 1834.828 -0.9 165684.5* FOXO_KO.1 4.2626 0.2988 99.9 1834.826 1834.828 -0.8 234920.2IPI:IPI00 3 3 4.30% 1284 148145 8.4 U Tax_Id=10090 Gene_Symbol=Myo6 MKIAA0389 protein IPI:IPI00 3 3 4.40% 1253 144773 8.5 U Tax_Id=10090 Gene_Symbol=Myo6 Putative uncharacterized protein IPI:IPI00 3 3 4.30% 1266 146307 8.5 U Tax_Id=10090 Gene_Symbol=Myo6 146 kDa protein IPI:IPI00 3 3 4.40% 1262 145805 8.5 U Tax_Id=10090 Gene_Symbol=Myo6 myosin VI


IPI:IPI00 1 1 4.30% 398 43567 7.6 U Tax_Id=10090 Gene_Symbol=Cth Cystathionine gamma-lyase * FOXO_KO.3 5.626 0.4191 100 1960.956 1958.955 -2.9 173645.1IPI:IPI00 1 1 4.30% 346 38649 8.5 U Tax_Id=10090 Gene_Symbol=LOC100045982 similar to MOSC domain-containing protein 1, mitochondrial isoform 2 IPI:IPI00 1 1 4.40% 342 38138 8.5 U Tax_Id=10090 Gene_Symbol=Mosc1 MOCO sulphurase C-terminal domain containing 1

FOXO_KO.3 6.5132 0.4459 100 1714.768 1712.758 1.5 305329.4IPI:IPI00 2 2 4.30% 327 34307 10.2 U Tax_Id=10090 Gene_Symbol=Fbl;LOC100044829 rRNA 2'-O-methyltransferase fibrillarin IPI:IPI00 2 2 5.20% 271 28922 9.6 U Tax_Id=10090 Gene_Symbol=LOC100044829 similar to Fibrillarin isoform 2

FOXO_KO.9 2.7219 0.3095 99.7 1666.839 1666.84 -0.1 203597FOXO_KO.1 3.6424 0.4539 100 1510.737 1510.738 -0.6 311191.8

IPI:IPI00 2 2 4.30% 255 28405 5.4 U Tax_Id=10090 Gene_Symbol=Psma3 Proteasome subunit alpha type-3 IPI:IPI008 2 2 6.10% 180 20320 5.2 U Tax_Id=10090 Gene_Symbol=Psma3 Putative uncharacterized protein IPI:IPI004 2 2 4.30% 254 28654 5.6 U Tax_Id=10090 Gene_Symbol=Gm13835 similar to proteasome alpha7/C8 subunit

FOXO_KO.1 3.1809 0.3063 99.9 1352.686 1351.685 -1.9 143961.4FOXO_KO.1 3.0081 0.3217 99.9 1351.685 1351.685 0.2 248402.6

IPI:IPI00 3 3 4.20% 1107 128564 9.3 U Tax_Id=10090 Gene_Symbol=Myo1b myosin IB isoform 2 IPI:IPI007 3 3 4.20% 1084 125702 9.1 U Tax_Id=10090 Gene_Symbol=Myo1b Isoform 2 of Myosin-Ib IPI:IPI00 3 3 4.30% 1078 125034 9.1 U Tax_Id=10090 Gene_Symbol=Myo1b Putative uncharacterized protein IPI:IPI004 3 3 4.00% 1136 132054 9.3 U Tax_Id=10090 Gene_Symbol=Myo1b myosin IB isoform 1

FOXO_KO.6 3.7991 0.3564 99.9 2668.423 2666.422 -2.1 38697.9FOXO_KO.3 5.2537 0.3374 100 2388.194 2387.188 1.2 72147.6FOXO_KO.3 3.1783 0.2627 99.5 2387.194 2387.188 2.6 198603.3

IPI:IPI00 2 2 4.20% 980 109894 5.6 U Tax_Id=10090 Gene_Symbol=Ppfibp1 Isoform 3 of Liprin-beta-1 IPI:IPI00 2 2 4.20% 980 109908 5.6 U Tax_Id=10090 Gene_Symbol=LOC100046025 similar to mKIAA1230 protein isoform 2 IPI:IPI00 2 2 4.20% 969 108554 5.5 U Tax_Id=10090 Gene_Symbol=LOC100046025 similar to mKIAA1230 protein isoform 3 IPI:IPI00 2 2 4.10% 1004 112536 5.7 U Tax_Id=10090 Gene_Symbol=LOC100046025 similar to mKIAA1230 protein isoform 1 IPI:IPI00 2 2 4.20% 969 108540 5.5 U Tax_Id=10090 Gene_Symbol=Ppfibp1 Isoform 1 of Liprin-beta-1

FOXO_KO.3 4.5056 0.3947 99.9 2772.433 2771.431 -0.4 76245.7FOXO_KO.3 4.5798 0.4805 100 1751.896 1750.893 -0.5 136623.9

IPI:IPI00 2 3 4.20% 911 105531 5.8 U Tax_Id=10090 Gene_Symbol=Eif3c Eukaryotic translation initiation factor 3 subunit C * FOXO_KO.4 5.8413 0.5131 100 2294.129 2293.123 0.9 97848.7

FOXO_KO.1 6.9951 0.5233 100 2137.899 2136.899 -1.3 55269.9IPI:IPI00 1 1 4.20% 595 65725 8.7 U Tax_Id=10090 Gene_Symbol=A1cf Isoform 1 of APOBEC1 complementation factor IPI:IPI006 1 1 4.30% 587 64779 8.8 U Tax_Id=10090 Gene_Symbol=A1cf Isoform 2 of APOBEC1 complementation factor IPI:IPI006 1 1 6.50% 384 43053 8.9 U Tax_Id=10090 Gene_Symbol=A1cf Isoform 3 of APOBEC1 complementation factor

FOXO_KO.3 5.0037 0.4806 100 2852.42 2852.417 1 85743.6IPI:IPI00 1 2 4.20% 473 52545 6.4 U Tax_Id=10090 Gene_Symbol=Sptlc1 Putative uncharacterized protein IPI:IPI003 1 2 4.20% 473 52491 6.4 U Tax_Id=10090 Gene_Symbol=Sptlc1 Serine palmitoyltransferase 1

FOXO_KO.2 3.4249 0.252 99.6 2377.237 2376.233 0 162211.2IPI:IPI00 1 1 4.20% 457 50709 5.9 U Tax_Id=10090 Gene_Symbol=Krt7 Keratin, type II cytoskeletal 7 contamina 1 1 4.10% 468 51203 5.5 U no description

FOXO_KO.2 5.1816 0.4705 100 2109.016 2109.013 1.5 81687.8IPI:IPI00 1 1 4.20% 456 50214 6.4 U Tax_Id=10090 Gene_Symbol=Ruvbl1 RuvB-like 1 IPI:IPI00 1 1 4.20% 456 50214 6.4 U Tax_Id=10090 Gene_Symbol=Ruvbl1 Putative uncharacterized protein

FOXO_KO.2 5.089 0.3932 100 2282.087 2281.087 -1.4 163547.8IPI:IPI00 1 2 4.20% 432 47688 6.5 U Tax_Id=10090 Gene_Symbol=Ahcy;Gm9826 Adenosylhomocysteinase IPI:IPI00 1 2 8.30% 216 23436 5.8 U Tax_Id=10090 Gene_Symbol=LOC677344 similar to S-adenosylhomocysteine hydrolase

FOXO_KO.3 5.4732 0.4512 100 2300.053 2298.038 3.2 80336.1IPI:IPI00 1 3 4.20% 358 41276 7 U Tax_Id=10090 Gene_Symbol=Mapk1 Mitogen-activated protein kinase 1 IPI:IPI00 1 3 3.90% 380 42402 8.6 U Tax_Id=10090 Gene_Symbol=Mapk3 42 kDa protein IPI:IPI00 1 3 5.70% 265 30626 5.8 U Tax_Id=10090 Gene_Symbol=Mapk3 Putative uncharacterized protein IPI:IPI00 1 3 5.20% 291 33601 8.7 U Tax_Id=10090 Gene_Symbol=Mapk1 ERK2 IPI:IPI00 1 3 3.90% 380 43067 6.6 U Tax_Id=10090 Gene_Symbol=Mapk3 Mitogen-activated protein kinase 3

FOXO_KO.3 5.5867 0.4279 100 1845.905 1844.899 1.9 68054.4IPI:IPI00 1 1 4.20% 312 36166 7.5 U Tax_Id=10090 Gene_Symbol=Eif4a2 eukaryotic translation initiation factor 4A2 isoform b

FOXO_KO.3 5.1986 0.4433 100 1556.713 1555.713 -2.4 332300.8IPI:IPI00 1 1 4.20% 308 34567 5.1 U Tax_Id=10090 Gene_Symbol=Cope Coatomer subunit epsilon IPI:IPI00 1 1 5.60% 234 26257 5.3 U Tax_Id=10090 Gene_Symbol=Cope 26 kDa protein IPI:IPI00 1 1 5.70% 227 25370 4.7 U Tax_Id=10090 Gene_Symbol=Cope 25 kDa protein

FOXO_KO.2 3.3397 0.2685 99.9 1562.783 1562.784 -0.5 204540.4IPI:IPI00 1 3 4.20% 287 31866 9 U Tax_Id=10090 Gene_Symbol=Pgam5 Isoform 2 of Serine/threonine-protein phosphatase PGAM5, mitochondrial IPI:IPI00 1 3 4.20% 288 31994 9 U Tax_Id=10090 Gene_Symbol=Pgam5 Isoform 1 of Serine/threonine-protein phosphatase PGAM5, mitochondrial IPI:IPI00 1 3 4.80% 252 28778 9.8 U Tax_Id=10090 Gene_Symbol=Pgam5 29 kDa protein

FOXO_KO.1 2.8847 0.4042 100 1335.604 1335.602 1.6 186649.8IPI:IPI00 2 5 4.10% 874 96759 6.5 U Tax_Id=10090 Gene_Symbol=Pdcd6ip Isoform 3 of Programmed cell death 6-interacting protein IPI:IPI00 2 5 4.10% 872 96312 6.5 U Tax_Id=10090 Gene_Symbol=Pdcd6ip programmed cell death 6 interacting protein isoform 2 IPI:IPI009 2 5 4.10% 874 96773 6.5 U Tax_Id=10090 Gene_Symbol=Pdcd6ip programmed cell death 6 interacting protein isoform 1

IPI:IPI00 2 5 4.10% 869 96024 6.5 U Tax_Id=10090 Gene_Symbol=Pdcd6ip programmed cell death 6 interacting protein isoform 3 FOXO_KO.1 4.974 0.4741 100 1533.709 1532.707 -1.2 272329.9FOXO_KO.3 2.9026 0.4069 99.9 2505.293 2504.288 0.5 191423.8

IPI:IPI00 1 2 4.10% 706 80209 6.7 U Tax_Id=10090 Gene_Symbol=Trap1 Heat shock protein 75 kDa, mitochondrial * FOXO_KO.5 4.3874 0.3494 99.9 3201.596 3199.583 2.2 42897.2IPI:IPI00 1 1 4.10% 579 65461 7.1 U Tax_Id=10090 Gene_Symbol=Cdc40 Pre-mRNA-processing factor 17 * FOXO_KO.1 4.3722 0.4311 100 2794.371 2793.368 0 52036.4IPI:IPI00 2 2 4.10% 580 64464 9.1 U Tax_Id=10090 Gene_Symbol=Nop56 Nucleolar protein 56 IPI:IPI00 2 2 8.10% 296 32983 9.3 U Tax_Id=10090 Gene_Symbol=Nop56 Nucleolar protein 5A

FOXO_KO.1 6.1784 0.4319 100 2579.181 2578.182 -2 51260.1FOXO_KO.1 4.2971 0.4382 100 2579.182 2578.182 -1.6 113479.2

IPI:IPI00 1 1 4.10% 515 58280 8.6 U Tax_Id=10090 Gene_Symbol=Eif2ak2 Interferon-induced, double-stranded RNA-activated protein kinase * FOXO_KO.4 4.0519 0.3341 100 2350.113 2348.108 -0.9 31840.4IPI:IPI00 1 1 4.10% 460 52214 5.4 U Tax_Id=10090 Gene_Symbol=Znhit6 Isoform 1 of Box C/D snoRNA protein 1 IPI:IPI00 1 1 4.10% 460 52213 5.6 U Tax_Id=10090 Gene_Symbol=Znhit6 MCG7779, isoform CRA_c

FOXO_KO.2 3.4632 0.3523 99.9 2320.166 2319.16 0.9 159660.2IPI:IPI00 2 2 4.10% 415 47148 5.7 U Tax_Id=10090 Gene_Symbol=Lrrfip2 Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 IPI:IPI00 2 2 4.20% 400 45539 5.6 U Tax_Id=10090 Gene_Symbol=Lrrfip2 Isoform 2 of Leucine-rich repeat flightless-interacting protein 2 IPI:IPI00 2 2 2.40% 722 82070 6.9 U Tax_Id=10090 Gene_Symbol=Lrrfip2 Putative uncharacterized protein

FOXO_KO.1 4.0561 0.383 100 1917.959 1916.956 -0.1 182768FOXO_KO.1 4.3409 0.2877 99.9 1917.954 1916.956 -2.9 181361.3

IPI:IPI001 1 1 4.10% 394 45664 6 U Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-1 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short IPI:IPI007 1 1 4.40% 362 41818 5.3 U Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-3 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short IPI:IPI00 1 1 4.20% 379 44178 6.5 U Tax_Id=10090 Gene_Symbol=Gnas 44 kDa protein IPI:IPI00 1 1 1.40% 1119 120107 4.8 U Tax_Id=10090 Gene_Symbol=Gnas Isoform XLas-4 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas IPI:IPI004 1 1 4.20% 380 44265 6.5 U Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short IPI:IPI00 1 1 1.40% 1133 121505 4.8 U Tax_Id=10090 Gene_Symbol=Gnas Isoform XLas-1 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

FOXO_KO.9 3.8409 0.3703 100 1774.775 1774.777 -0.8 139499.9IPI:IPI00 1 1 4.10% 389 45536 5.5 U Tax_Id=10090 Gene_Symbol=Psmd6 26S proteasome non-ATPase regulatory subunit 6 * FOXO_KO.9 2.9799 0.3468 99.9 1856.968 1856.971 -1.8 209279IPI:IPI001 1 3 4.10% 416 43517 4.8 U Tax_Id=10090 Gene_Symbol=Rad23b UV excision repair protein RAD23 homolog B IPI:IPI00 1 3 4.10% 416 43513 4.8 U Tax_Id=10090 Gene_Symbol=Rad23b RAD23b homolog

FOXO_KO.3 3.1026 0.2377 99.6 1995.916 1994.909 1.8 51612.3IPI:IPI00 1 1 4.10% 394 43009 6.1 U Tax_Id=10090 Gene_Symbol=Ndrg1 Protein NDRG1 * FOXO_KO.1 2.8472 0.3556 99.9 1834.998 1833.996 -0.6 239395.4IPI:IPI00 1 1 4.10% 365 40890 10.8 U Tax_Id=10090 Gene_Symbol=Rnps1 RNA/DNA-binding protein IPI:IPI008 1 1 5.30% 282 31739 11.9 U Tax_Id=10090 Gene_Symbol=Gm9825 similar to Rnps1 protein IPI:IPI00 1 1 5.30% 282 31709 11.9 U Tax_Id=10090 Gene_Symbol=Rnps1 Isoform 2 of RNA-binding protein with serine-rich domain 1 IPI:IPI00 1 1 4.90% 305 34208 11.8 U Tax_Id=10090 Gene_Symbol=Rnps1 Isoform 1 of RNA-binding protein with serine-rich domain 1

FOXO_KO.1 4.9794 0.4275 100 1760.766 1760.765 0.4 150743.2IPI:IPI00 1 1 4.10% 343 38285 9 U Tax_Id=10090 Gene_Symbol=Bdh1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial IPI:IPI00 1 1 4.10% 343 38299 9 U Tax_Id=10090 Gene_Symbol=Bdh1 3-hydroxybutyrate dehydrogenase, type 1 precursor IPI:IPI00 1 1 5.30% 265 29147 9.6 U Tax_Id=10090 Gene_Symbol=Bdh1 29 kDa protein

FOXO_KO.1 3.6856 0.3032 99.9 1662.8 1662.8 -0.3 261626.1IPI:IPI00 1 1 4.10% 296 34269 9.8 U Tax_Id=10090 Gene_Symbol=Rpl5 Ribosomal protein L5

FOXO_KO.1 2.7544 0.3178 99.9 1533.677 1533.678 -0.8 253192.6IPI:IPI00 1 2 4.10% 268 29494 5.2 U Tax_Id=10090 Gene_Symbol=Hmgcs1 Putative uncharacterized protein

FOXO_KO.1 3.2874 0.4323 100 1217.661 1217.662 -1.1 298965.8

IPI:IPI00 5 5 4.00% 2388 270933 5.9 U Tax_Id=10090 Gene_Symbol=Spnb3 Putative uncharacterized protein FOXO_KO.1 3.4518 0.2963 99.9 1923.932 1922.934 -2.6 285415.2

* FOXO_KO.1 4.4628 0.4469 100 1725.819 1725.818 0.4 165947.3* FOXO_KO.2 5.8543 0.427 100 2828.377 2827.37 1.1 66453.5* FOXO_KO.2 4.5252 0.4349 100 2393.005 2391.005 -2.8 133943.2* FOXO_KO.5 4.8813 0.4626 100 1973.988 1973.981 3.1 49487.9IPI:IPI00 5 8 4.00% 2296 252999 6.1 U Tax_Id=10090 Gene_Symbol=Fn1 Putative uncharacterized protein IPI:IPI00 5 8 3.90% 2361 260126 5.9 U Tax_Id=10090 Gene_Symbol=Fn1 Putative uncharacterized protein

FOXO_KO.1 5.2374 0.5019 100 2074.85 2073.853 -3.1 102943.1FOXO_KO.1 4.6938 0.4637 100 2197.93 2196.925 0.6 76157.9FOXO_KO.1 4.6145 0.4601 100 2196.92 2196.925 -2.2 233079.6FOXO_KO.3 3.0528 0.2843 99.5 3646.765 3646.765 0.2 39536.6FOXO_KO.2 4.7524 0.3994 100 2420.234 2419.235 -1.8 99906.1

IPI:IPI00 5 6 4.00% 1998 226356 6.2 U Tax_Id=10090 Gene_Symbol=Myo18a Isoform 4 of Myosin-XVIIIa FOXO_KO.3 4.097 0.331 100 1487.783 1487.784 -0.7 143555.8FOXO_KO.2 5.0569 0.3912 100 3166.504 3165.503 -0.8 54933.8FOXO_KO.1 5.924 0.4791 100 1792.838 1791.835 -0.6 127003.6FOXO_KO.3 4.8086 0.4669 100 2577.299 2576.294 0.6 154869FOXO_KO.1 4.068 0.2178 99.9 1623.685 1623.688 -1.7 115512.2

IPI:IPI00 2 3 4.00% 1114 124682 5.3 U Tax_Id=10090 Gene_Symbol=Eif2ak3 Eukaryotic translation initiation factor 2-alpha kinase 3 FOXO_KO.2 4.2404 0.2584 99.9 2651.328 2650.321 1.7 93012.7

* FOXO_KO.3 4.6314 0.3127 100 2307.063 2306.061 -0.3 83684.9IPI:IPI00 2 2 4.00% 1058 117809 5.7 U Tax_Id=10090 Gene_Symbol=Uba1 Ubiquitin-like modifier-activating enzyme 1 * FOXO_KO.2 4.6527 0.4427 100 1899.946 1899.941 2.8 58655.8

FOXO_KO.1 4.1492 0.3216 99.9 2684.315 2683.317 -2 99887.1IPI:IPI00 1 2 4.00% 729 82229 7.2 U Tax_Id=10090 Gene_Symbol=Eps8l2 Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 2 IPI:IPI00 1 2 7.20% 400 44740 8 U Tax_Id=10090 Gene_Symbol=Eps8l2 Isoform 2 of Epidermal growth factor receptor kinase substrate 8-like protein 2

FOXO_KO.3 5.6887 0.5035 100 3378.74 3376.738 -1.6 68067.4IPI:IPI00 1 1 4.00% 642 71581 5.5 U Tax_Id=10090 Gene_Symbol=Ivns1abp Isoform 1 of Influenza virus NS1A-binding protein homolog * FOXO_KO.4 3.4285 0.2368 99.5 3086.393 3086.394 -0.2 45302.3IPI:IPI00 1 1 4.00% 656 70876 8.7 U Tax_Id=10090 Gene_Symbol=Acadvl Very long-chain specific acyl-CoA dehydrogenase, mitochondrial IPI:IPI00 1 1 4.10% 634 68551 8.8 U Tax_Id=10090 Gene_Symbol=Acadvl Acyl-Coenzyme A dehydrogenase, very long chain

FOXO_KO.2 5.7385 0.4466 100 2966.452 2964.447 -0.8 148250.9IPI:IPI00 1 1 4.00% 530 60372 8.1 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5;LOC100048744;LOC100048662 UDP glycosyltransferase 1 family polypeptide A13 IPI:IPI00 1 1 10.10% 207 22562 6.4 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 23 kDa protein IPI:IPI00 1 1 10.10% 207 22682 6.3 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 23 kDa protein IPI:IPI00 1 1 12.70% 166 18261 8.4 U Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 18 kDa protein

FOXO_KO.4 6.551 0.5794 100 2175.111 2174.101 2.9 163445.1IPI:IPI00 1 1 4.00% 527 59765 7.9 U Tax_Id=10090 Gene_Symbol=Cat Catalase IPI:IPI00 1 1 4.00% 527 59795 7.9 U Tax_Id=10090 Gene_Symbol=Cat catalase IPI:IPI00 1 1 11.90% 176 19677 9.1 U Tax_Id=10090 Gene_Symbol=Cat Catalase, isoform CRA_a

FOXO_KO.3 3.7088 0.3516 99.9 2475.211 2474.213 -2 181976.2IPI:IPI00 1 1 4.00% 521 57923 4.9 U Tax_Id=10090 Gene_Symbol=Kpna4 Importin subunit alpha-4 * FOXO_KO.3 5.4584 0.5039 100 2321.064 2321.064 0.2 88906IPI:IPI00 2 2 4.00% 452 49508 7.6 U Tax_Id=10090 Gene_Symbol=Tufm Isoform 1 of Elongation factor Tu, mitochondrial IPI:IPI00 2 2 4.00% 452 49538 7.6 U Tax_Id=10090 Gene_Symbol=- hypothetical protein IPI:IPI00 2 2 4.10% 435 47222 7.7 U Tax_Id=10090 Gene_Symbol=Tufm Isoform 2 of Elongation factor Tu, mitochondrial

FOXO_KO.3 7.405 0.4716 100 2047.011 2046.006 0.9 138693.7

FOXO_KO.3 3.5123 0.2587 99.7 2046.009 2046.006 1.6 140244.9IPI:IPI001 1 1 4.00% 402 43529 5.2 U Tax_Id=10090 Gene_Symbol=Fkbp8 Isoform 1 of Peptidyl-prolyl cis-trans isomerase FKBP8 IPI:IPI00 1 1 4.00% 403 43616 5.2 U Tax_Id=10090 Gene_Symbol=Fkbp8 Isoform 2 of Peptidyl-prolyl cis-trans isomerase FKBP8

FOXO_KO.1 4.7588 0.4888 100 1748.783 1747.78 -0.2 212207.8IPI:IPI00 1 2 4.00% 353 38385 8.9 U Tax_Id=10090 Gene_Symbol=Stoml2 Stomatin-like protein 2 IPI:IPI00 1 2 4.60% 307 33217 7.3 U Tax_Id=10090 Gene_Symbol=Stoml2 Stomatin (Epb7.2)-like 2

FOXO_KO.1 4.9793 0.4296 100 1534.742 1533.739 -0.3 148125.3IPI:IPI00 1 1 4.00% 329 35560 7.9 U Tax_Id=10090 Gene_Symbol=Ptgr1 Prostaglandin reductase 1 * FOXO_KO.1 3.1826 0.3394 99.9 1626.729 1625.726 -0.5 259530.6IPI:IPI00 1 1 4.00% 249 27426 8.8 U Tax_Id=10090 Gene_Symbol=Flna Isoform 2 of Filamin-A IPI:IPI00 1 1 0.40% 2704 288590 6 U Tax_Id=10090 Gene_Symbol=Flnc Isoform 2 of Filamin-C IPI:IPI00 1 1 0.40% 2737 292344 6 U Tax_Id=10090 Gene_Symbol=Flnc Isoform 1 of Filamin-C

FOXO_KO.1 2.6447 0.244 99.6 1172.592 1172.595 -2.3 267286.7IPI:IPI00 2 4 3.90% 887 102706 5.3 U Tax_Id=10090 Gene_Symbol=Nedd4 E3 ubiquitin-protein ligase NEDD4

FOXO_KO.3 5.5417 0.3617 100 2287.151 2285.145 -0.2 125187.6FOXO_KO.3 3.9115 0.4111 100 1867.884 1866.88 0.8 74873.5

IPI:IPI00 2 4 3.90% 862 98116 8.3 U Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 IPI:IPI00 2 5 3.80% 886 100915 8.3 U Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 IPI:IPI00 2 5 4.70% 727 83068 6.6 U Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 IPI:IPI00 2 5 3.90% 861 98089 8.3 U Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 IPI:IPI00 2 5 3.80% 887 100942 8.3 U Tax_Id=10090 Gene_Symbol=Exosc10 exosome component 10 IPI:IPI00 2 5 4.70% 728 83125 6.6 U Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 IPI:IPI00 2 5 3.80% 887 100972 8.3 U Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10

FOXO_KO.3 5.6364 0.3925 100 2441.214 2439.207 0 160916.2FOXO_KO.2 3.6834 0.2977 99.9 1586.752 1586.749 1.9 245772.7

IPI:IPI004 1 1 3.90% 776 89414 4.4 U Tax_Id=10090 Gene_Symbol=Las1l Isoform 1 of Protein LAS1 homolog IPI:IPI00 1 1 4.00% 759 87579 4.4 U Tax_Id=10090 Gene_Symbol=Las1l Isoform 2 of Protein LAS1 homolog

FOXO_KO.4 5.361 0.372 100 3518.673 3516.666 0 86719.6IPI:IPI00 1 3 3.90% 589 65323 5.1 U Tax_Id=10090 Gene_Symbol=Ppp2r1a Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform * FOXO_KO.4 6.9185 0.4984 100 2752.429 2750.418 1.4 119186.9IPI:IPI00 1 2 3.90% 567 64910 6.6 U Tax_Id=10090 Gene_Symbol=Riok1 Serine/threonine-protein kinase RIO1 * FOXO_KO.3 5.9215 0.4928 100 2536.172 2534.164 0.2 50056IPI:IPI00 2 4 3.90% 535 57916 8.1 U Tax_Id=10090 Gene_Symbol=Aldh6a1 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial * FOXO_KO.5 6.9678 0.5692 100 2345.258 2344.253 0.7 77810.4* FOXO_KO.5 4.219 0.386 99.9 2345.26 2344.253 1.5 107890.5IPI:IPI00 1 2 3.90% 519 56725 7.2 U Tax_Id=10090 Gene_Symbol=Dpys Dihydropyrimidinase * FOXO_KO.3 6.0375 0.5016 100 2190.114 2189.108 0.8 126993.8IPI:IPI00 1 1 3.90% 437 50649 8.6 U Tax_Id=10090 Gene_Symbol=Sept7 cell division cycle 10 homolog IPI:IPI00 1 1 3.90% 436 50550 8.6 U Tax_Id=10090 Gene_Symbol=Sept7 Septin-7

FOXO_KO.1 5.9684 0.5531 100 2098.991 2097.986 0.7 111798.5IPI:IPI00 1 1 3.90% 439 50552 7.9 U Tax_Id=10090 Gene_Symbol=Acot10 Acyl-coenzyme A thioesterase 10, mitochondrial IPI:IPI00 1 1 3.90% 439 50560 8.6 U Tax_Id=10090 Gene_Symbol=Acot9 Acyl-coenzyme A thioesterase 9, mitochondrial

FOXO_KO.3 4.5089 0.5083 100 1931.021 1930.017 0.4 117709.7IPI:IPI00 1 2 3.90% 435 49373 6.4 U Tax_Id=10090 Gene_Symbol=Lgmn Legumain * FOXO_KO.3 4.9699 0.3279 100 1939.947 1938.944 -0.4 100577.9IPI:IPI00 1 1 3.90% 410 47016 7.6 U Tax_Id=10090 Gene_Symbol=Fam82a1 Regulator of microtubule dynamics protein 2 * FOXO_KO.3 3.5711 0.2887 99.9 1974.021 1974.021 -0.2 141507.3IPI:IPI00 1 1 3.90% 381 41836 8.6 U Tax_Id=10090 Gene_Symbol=Hsd17b2 Estradiol 17-beta-dehydrogenase 2

* FOXO_KO.1 5.5868 0.4833 100 1837.835 1837.835 0.1 101222IPI:IPI001 2 2 3.90% 362 40711 6.2 U Tax_Id=10090 Gene_Symbol=H2-L H-2 class I histocompatibility antigen, L-D alpha chain IPI:IPI00 2 2 8.90% 158 18271 5.6 U Tax_Id=10090 Gene_Symbol=Gm8810 MHC class I antigen (Fragment) IPI:IPI00 2 2 4.20% 332 37547 5.9 U Tax_Id=10090 Gene_Symbol=H2-gs10 H2-gs10 protein IPI:IPI00 2 2 4.00% 354 39938 6.7 U Tax_Id=10090 Gene_Symbol=H2-Q10 40 kDa protein IPI:IPI00 2 2 3.60% 393 44409 6.3 U Tax_Id=10090 Gene_Symbol=Gm8909 hypothetical protein LOC667977 IPI:IPI00 2 2 4.20% 332 37672 5.9 U Tax_Id=10090 Gene_Symbol=H2-L H2-D1 protein (Fragment) IPI:IPI00 2 2 6.80% 206 23727 6.7 U Tax_Id=10090 Gene_Symbol=H2-D1 MHC class I L-q alpha-chain gene (H2 haplotype), exons 1-3 (Fragment) IPI:IPI00 2 2 10.80% 130 14481 6.3 U Tax_Id=10090 Gene_Symbol=H2-Q1 14 kDa protein IPI:IPI00 2 2 4.70% 301 34043 6.2 U Tax_Id=10090 Gene_Symbol=H2-Q2 H2-D1 protein (Fragment) IPI:IPI00 2 2 4.10% 343 38861 6.5 U Tax_Id=10090 Gene_Symbol=H2-Q2 H2-D1 protein (Fragment) IPI:IPI00 2 2 3.70% 382 43099 5.9 U Tax_Id=10090 Gene_Symbol=Gm8909 MHC classIb T5 IPI:IPI00 2 2 5.40% 257 28624 5.8 U Tax_Id=10090 Gene_Symbol=H2-Bl Truncated MHC class I antigen splice variant Bl.2 IPI:IPI00 2 2 6.80% 206 23578 6.4 U Tax_Id=10090 Gene_Symbol=H2-D1 MHC class I D-q alpha-chain (H2 haplotype), exons 1-3 (Fragment) IPI:IPI00 2 2 4.00% 346 39594 7.2 U Tax_Id=10090 Gene_Symbol=LOC634869 similar to major histocompability complex Q1b IPI:IPI00 2 2 4.20% 337 38261 6.2 U Tax_Id=10090 Gene_Symbol=H2-L H-2D cell surface glycoprotein (Fragment) IPI:IPI00 2 2 4.20% 337 38362 6.4 U Tax_Id=10090 Gene_Symbol=H2-L H-2D cell surface glycoprotein (Fragment) IPI:IPI00 2 2 3.80% 365 41151 6.7 U Tax_Id=10090 Gene_Symbol=H2-D1 H-2 class I histocompatibility antigen, D-B alpha chain IPI:IPI00 2 2 3.80% 368 41322 7 U Tax_Id=10090 Gene_Symbol=H2-Q1 MCG68121, isoform CRA_b IPI:IPI00 2 2 3.90% 363 41267 5.9 U Tax_Id=10090 Gene_Symbol=H2-Q10 41 kDa protein IPI:IPI00 2 2 3.70% 382 42880 6.5 U Tax_Id=10090 Gene_Symbol=LOC547349 MHC class I antigen IPI:IPI00 2 2 4.00% 354 39618 6.6 U Tax_Id=10090 Gene_Symbol=H2-gs10 MHC class I like protein GS10 IPI:IPI00 2 2 4.20% 337 38345 6.4 U Tax_Id=10090 Gene_Symbol=H2-L H-2D cell surface glycoprotein (Fragment) IPI:IPI00 2 2 4.00% 354 39622 6.3 U Tax_Id=10090 Gene_Symbol=H2-gs10 40 kDa protein IPI:IPI00 2 2 7.40% 188 21486 11 U Tax_Id=10090 Gene_Symbol=H2-Q10 H2-Q10 protein (Fragment) IPI:IPI00 2 2 3.90% 360 40504 5.4 U Tax_Id=10090 Gene_Symbol=H2-Q2;H2-Q1 Class Ib major histocompatibility complex IPI:IPI00 2 2 4.30% 325 37251 5.2 U Tax_Id=10090 Gene_Symbol=H2-Q10 H-2 class I histocompatibility antigen, Q10 alpha chain IPI:IPI00 2 2 4.00% 353 39880 7 U Tax_Id=10090 Gene_Symbol=H2-D1 H-2D cell surface glycoprotein IPI:IPI00 2 2 4.00% 349 39422 5.7 U Tax_Id=10090 Gene_Symbol=H2-Bl Major histocompatibility complex class I b

FOXO_KO.2 5.1479 0.4116 100 1807.772 1807.774 -1.2 177594.8FOXO_KO.2 3.8971 0.3159 100 1639.683 1639.685 -0.8 264533.7

IPI:IPI00 1 1 3.90% 232 26317 4.9 U Tax_Id=10090 Gene_Symbol=Krt42 Putative uncharacterized protein FOXO_KO.2 2.8754 0.402 100 1172.524 1172.526 -1.7 175608.3

IPI:IPI00 3 4 3.80% 1304 145816 7.1 U Tax_Id=10090 Gene_Symbol=Sf3b1 Splicing factor 3B subunit 1 * FOXO_KO.1 4.9575 0.394 100 2087.052 2087.05 0.6 106741.4* FOXO_KO.1 3.8955 0.4279 100 1721.87 1721.87 -0.1 164540.7

FOXO_KO.4 3.4312 0.4208 100 1998 1997.989 5.6 51047.1IPI:IPI00 3 4 3.80% 1217 135550 5.3 U Tax_Id=10090 Gene_Symbol=Sf3b3 Isoform 1 of Splicing factor 3B subunit 3 IPI:IPI00 3 4 4.10% 1122 125308 5.5 U Tax_Id=10090 Gene_Symbol=Sf3b3 Isoform 2 of Splicing factor 3B subunit 3

FOXO_KO.2 4.5483 0.5143 100 1664.806 1664.805 0.7 267118.9FOXO_KO.9 5.4946 0.473 100 1855.839 1854.835 0.4 123438.9FOXO_KO.1 5.0248 0.3718 100 1700.851 1699.85 -1.3 144426.4

IPI:IPI00 1 1 3.80% 683 76206 7.1 U Tax_Id=10090 Gene_Symbol=Acsl5 Long-chain-fatty-acid--CoA ligase 5 * FOXO_KO.4 4.6566 0.3792 99.9 3068.539 3066.528 1.2 69491.3IPI:IPI00 1 1 3.80% 627 69739 5.9 U Tax_Id=10090 Gene_Symbol=Rhot2 70 kDa protein IPI:IPI00 1 1 3.90% 620 69071 6 U Tax_Id=10090 Gene_Symbol=Rhot2 Mitochondrial Rho GTPase 2

FOXO_KO.2 4.8581 0.3853 100 2855.354 2853.343 1.6 63902IPI:IPI00 3 4 3.80% 637 65606 8.1 U Tax_Id=10090 Gene_Symbol=Krt1 Keratin, type II cytoskeletal 1


IPI:IPI00 3 4 3.80% 572 61359 8 U Tax_Id=10090 Gene_Symbol=Krt77 Keratin, type II cytoskeletal 1b FOXO_KO.1 4.5895 0.3602 100 1475.782 1475.785 -2.1 241573.9FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715

IPI:IPI001 1 1 3.80% 524 57596 9.2 U Tax_Id=10090 Gene_Symbol=Eif2b4 Isoform 1 of Translation initiation factor eIF-2B subunit delta IPI:IPI00 1 1 3.80% 524 57624 9.3 U Tax_Id=10090 Gene_Symbol=Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta isoform 2 IPI:IPI00 1 1 3.50% 566 62353 9.2 U Tax_Id=10090 Gene_Symbol=Eif2b4 62 kDa protein IPI:IPI00 1 1 3.70% 544 59629 9.2 U Tax_Id=10090 Gene_Symbol=Eif2b4 Isoform 2 of Translation initiation factor eIF-2B subunit delta

FOXO_KO.2 5.9267 0.3527 100 2310.025 2309.024 -1 32257.3IPI:IPI00 1 1 3.80% 393 45054 7.1 U Tax_Id=10090 Gene_Symbol=Hpd 4-hydroxyphenylpyruvate dioxygenase IPI:IPI00 1 1 9.40% 159 17980 6.3 U Tax_Id=10090 Gene_Symbol=Hpd 18 kDa protein

FOXO_KO.1 5.2593 0.3579 100 1818.841 1817.837 0.3 138347.3IPI:IPI00 1 1 3.80% 373 42031 8 U Tax_Id=10090 Gene_Symbol=Hsd3b3 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 3 IPI:IPI00 1 1 3.80% 373 41923 6.4 U Tax_Id=10090 Gene_Symbol=Hsd3b2 3 beta-hydroxysteroid dehydrogenase 2 IPI:IPI00 1 1 3.80% 373 41977 6.4 U Tax_Id=10090 Gene_Symbol=Hsd3b6 3 beta-hydroxysteroid dehydrogenase 6 IPI:IPI00 1 1 4.40% 318 35996 7.8 U Tax_Id=10090 Gene_Symbol=Gm4450 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 3 IPI:IPI008 1 1 3.80% 373 41709 8.4 U Tax_Id=10090 Gene_Symbol=Gm4450 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 1 IPI:IPI00 1 1 4.40% 318 35995 8 U Tax_Id=10090 Gene_Symbol=Gm10681 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 3 IPI:IPI00 1 1 4.40% 318 36133 8 U Tax_Id=10090 Gene_Symbol=Hsd3b3 3 beta-hydroxysteroid dehydrogenase 3 isoform 2 IPI:IPI00 1 1 3.80% 373 41876 6.4 U Tax_Id=10090 Gene_Symbol=Hsd3b6 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 6 IPI:IPI002 1 1 3.80% 373 41995 6.5 U Tax_Id=10090 Gene_Symbol=Hsd3b2 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 2 IPI:IPI00 1 1 3.80% 373 41766 8.6 U Tax_Id=10090 Gene_Symbol=Hsd3b4;Gm10681 3 beta-hydroxysteroid dehydrogenase type 4

FOXO_KO.2 4.2064 0.2253 99.9 1635.787 1635.79 -2.2 214232.2IPI:IPI00 1 2 3.80% 373 41892 9 U Tax_Id=10090 Gene_Symbol=Hsd3b5 3 beta-hydroxysteroid dehydrogenase type 5 * FOXO_KO.2 4.1286 0.4631 100 1634.806 1634.806 0.1 148312IPI:IPI00 1 1 3.80% 317 35231 9.2 U Tax_Id=10090 Gene_Symbol=1810022C23Rik MCG120270, isoform CRA_a IPI:IPI00 1 1 3.10% 391 43268 8.9 U Tax_Id=10090 Gene_Symbol=Peci Isoform 1 of Peroxisomal 3,2-trans-enoyl-CoA isomerase IPI:IPI00 1 1 3.40% 358 39503 8.4 U Tax_Id=10090 Gene_Symbol=Peci Isoform 2 of Peroxisomal 3,2-trans-enoyl-CoA isomerase

FOXO_KO.1 2.7142 0.3018 99.8 1290.679 1290.679 -0.1 339696.1IPI:IPI00 4 9 3.70% 2007 232470 5.5 U Tax_Id=10090 Gene_Symbol=Myh10 Myosin, heavy polypeptide 10, non-muscle IPI:IPI00 4 9 3.70% 2013 233447 5.6 U Tax_Id=10090 Gene_Symbol=Myh10 Putative uncharacterized protein IPI:IPI00 4 9 3.80% 1976 228994 5.5 U Tax_Id=10090 Gene_Symbol=Myh10 Myosin-10

FOXO_KO.2 5.5851 0.4271 100 2288.117 2286.11 0.2 60350.5FOXO_KO.1 3.5795 0.3309 100 1223.636 1223.638 -1.6 244010FOXO_KO.5 3.983 0.3196 99.9 3062.515 3061.506 2 36796.8FOXO_KO.2 6.6273 0.4815 100 1962.925 1961.919 1.7 105101

IPI:IPI00 4 5 3.70% 1268 141742 6.9 U Tax_Id=10090 Gene_Symbol=Hdlbp Vigilin * FOXO_KO.5 5.2194 0.4766 100 3032.543 3030.534 0.8 47883.4* FOXO_KO.5 6.3973 0.53 100 2575.307 2574.301 1.3 23575.8* FOXO_KO.5 5.2367 0.3959 100 2576.312 2574.301 1.8 46037.6* FOXO_KO.3 3.3557 0.3929 99.9 2377.284 2376.281 -0.1 119104.7IPI:IPI002 1 1 3.70% 564 60790 6.9 U Tax_Id=10090 Gene_Symbol=Zyx Zyxin IPI:IPI00 1 1 3.90% 533 57027 6.6 U Tax_Id=10090 Gene_Symbol=Zyx Zyx protein IPI:IPI00 1 1 3.70% 564 60546 6.4 U Tax_Id=10090 Gene_Symbol=Zyx zyxin

FOXO_KO.4 5.8661 0.4292 100 2612.221 2611.213 2.1 38625.3

IPI:IPI00 1 2 3.70% 484 55793 10.3 U Tax_Id=10090 Gene_Symbol=Gltscr2 glioma tumor suppressor candidate region gene 2 * FOXO_KO.4 6.2323 0.5328 100 2073.062 2072.055 1.8 87218.3IPI:IPI00 1 2 3.70% 351 38513 5.1 U Tax_Id=10090 Gene_Symbol=Strap 39 kDa protein IPI:IPI00 1 2 3.70% 350 38442 5.1 U Tax_Id=10090 Gene_Symbol=Strap Serine-threonine kinase receptor-associated protein

FOXO_KO.1 5.6219 0.5141 100 1598.676 1596.67 -0.3 366069.2IPI:IPI00 1 14 3.70% 295 33393 10.8 U Tax_Id=10090 Gene_Symbol=Gm6807 similar to ribosomal protein L6 isoform 1 IPI:IPI008 1 14 3.90% 285 32276 10.7 U Tax_Id=10090 Gene_Symbol=Gm6807 similar to ribosomal protein L6 isoform 2

FOXO_KO.9 4.2966 0.4251 100 1334.611 1332.607 -1.6 546699.8IPI:IPI00 2 2 3.60% 858 95314 6.8 U Tax_Id=10090 Gene_Symbol=Eef2 Elongation factor 2 * FOXO_KO.2 3.4655 0.3561 100 2007.9 2007.904 -2 214076.3

FOXO_KO.1 4.1056 0.3788 100 1567.775 1567.778 -1.9 194277.4IPI:IPI00 1 1 3.60% 775 86015 6.2 U Tax_Id=10090 Gene_Symbol=Hgs Hepatocyte growth factor-regulated tyrosine kinase substrate IPI:IPI00 1 1 3.70% 767 85907 7.5 U Tax_Id=10090 Gene_Symbol=Hgs HGF-regulated tyrosine kinase substrate isoform 1

FOXO_KO.2 6.7483 0.3377 100 3245.581 3244.582 -1.1 87016.3IPI:IPI003 4 8 3.60% 633 69741 5.8 U Tax_Id=10090 Gene_Symbol=Hspa2 Heat shock-related 70 kDa protein 2 IPI:IPI00 4 8 3.60% 633 69642 5.7 U Tax_Id=10090 Gene_Symbol=Hspa2 heat shock protein 2

FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6FOXO_KO.2 3.4794 0.3266 100 1480.751 1480.754 -2.5 196915.1FOXO_KO.2 3.0387 0.2225 99.5 1480.755 1480.754 0.5 102785.9FOXO_KO.2 3.1533 0.3932 100 1253.616 1253.616 0.2 319502.1

IPI:IPI00 1 1 3.60% 661 69037 9.3 U Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1 IPI:IPI00 1 1 3.70% 655 68462 9.3 U Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1 IPI:IPI007 1 1 3.70% 655 68418 9.3 U Tax_Id=10090 Gene_Symbol=Ewsr1 RNA-binding protein EWS IPI:IPI00 1 1 6.80% 354 37616 8.1 U Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1 IPI:IPI00 1 1 3.90% 618 64988 9.4 U Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1

FOXO_KO.1 5.2632 0.47 100 2480.047 2480.053 -2.5 151119.5IPI:IPI00 1 1 3.60% 609 67936 8.1 U Tax_Id=10090 Gene_Symbol=Ctnnd1 68 kDa protein

FOXO_KO.4 5.2033 0.2597 100 2476.215 2475.207 1.8 90982.4IPI:IPI00 1 1 3.60% 557 65616 6.6 U Tax_Id=10090 Gene_Symbol=Ik IK cytokine IPI:IPI00 1 1 3.60% 557 65517 6.5 U Tax_Id=10090 Gene_Symbol=Ik Protein Red

FOXO_KO.1 3.3244 0.2418 99.5 2319.08 2318.078 -0.6 161917.5IPI:IPI00 1 1 3.60% 578 59691 6.9 U Tax_Id=10090 Gene_Symbol=Dak Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) * FOXO_KO.1 4.3811 0.5017 100 1952.961 1951.961 -1.7 142131.6IPI:IPI00 1 1 3.60% 529 56427 5.8 U Tax_Id=10090 Gene_Symbol=Flna 56 kDa protein

FOXO_KO.2 5.2947 0.3923 100 1938.018 1938.018 0.1 164713.5IPI:IPI00 1 1 3.60% 420 46482 6.7 U Tax_Id=10090 Gene_Symbol=Baat Bile acid-CoA:amino acid N-acyltransferase * FOXO_KO.4 4.0735 0.4435 100 1857.926 1857.927 -0.6 28895.5IPI:IPI00 1 1 3.60% 364 39507 8.3 U Tax_Id=10090 Gene_Symbol=Aldob Fructose-bisphosphate aldolase B * FOXO_KO.1 3.05 0.3267 99.9 1418.713 1418.712 0.8 166424.5IPI:IPI00 2 3 3.50% 686 77061 5.1 U Tax_Id=10090 Gene_Symbol=Tgm2 Protein-glutamine gamma-glutamyltransferase 2 * FOXO_KO.9 4.7793 0.4153 100 2836.31 2836.313 -1.1 98683.1* FOXO_KO.1 3.2675 0.2565 99.5 2437.086 2437.09 -1.8 203310.3IPI:IPI00 1 1 3.50% 622 69048 9.8 U Tax_Id=10090 Gene_Symbol=Wdr46 WD repeat-containing protein 46 * FOXO_KO.3 5.9814 0.5074 100 2304.13 2303.129 -1.1 100946.2IPI:IPI00 1 2 3.50% 566 64266 9 U Tax_Id=10090 Gene_Symbol=Elp3 Isoform 2 of Elongator complex protein 3 IPI:IPI008 1 2 3.70% 547 62385 8.9 U Tax_Id=10090 Gene_Symbol=Elp3 Isoform 1 of Elongator complex protein 3

FOXO_KO.4 4.083 0.3096 99.9 2414.195 2412.187 0.4 113784.2IPI:IPI00 1 1 3.50% 574 61734 8.9 U Tax_Id=10090 Gene_Symbol=Myef2 Isoform 2 of Myelin expression factor 2

IPI:IPI00 1 1 3.80% 530 57165 9.2 U Tax_Id=10090 Gene_Symbol=Myef2 Putative uncharacterized protein IPI:IPI00 1 1 3.60% 550 59543 8.8 U Tax_Id=10090 Gene_Symbol=Myef2 myelin basic protein expression factor 2, repressor isoform 3 IPI:IPI00 1 1 3.50% 567 61104 8.8 U Tax_Id=10090 Gene_Symbol=Myef2 Myelin basic protein expression factor 2, repressor IPI:IPI00 1 1 4.00% 498 53544 8.7 U Tax_Id=10090 Gene_Symbol=Myef2;Gm9833 Isoform 4 of Myelin expression factor 2 IPI:IPI00 1 1 3.60% 562 60335 9.2 U Tax_Id=10090 Gene_Symbol=LOC100045569 similar to Myef2 protein IPI:IPI00 1 1 3.40% 591 63295 8.9 U Tax_Id=10090 Gene_Symbol=Myef2 Isoform 1 of Myelin expression factor 2

FOXO_KO.1 3.0764 0.2599 99.5 2260.099 2259.1 -1.9 275198.9IPI:IPI00 1 1 3.50% 519 56141 7.7 U Tax_Id=10090 Gene_Symbol=Lap3 Isoform 1 of Cytosol aminopeptidase IPI:IPI008 1 1 3.70% 488 52750 7 U Tax_Id=10090 Gene_Symbol=Lap3 Isoform 2 of Cytosol aminopeptidase

FOXO_KO.1 5.6373 0.3706 100 2013.899 2013.904 -2.2 80219.4IPI:IPI00 1 1 3.50% 483 54192 8.7 U Tax_Id=10090 Gene_Symbol=Ddx6 Probable ATP-dependent RNA helicase DDX6 * FOXO_KO.1 5.779 0.5231 100 1964.893 1963.892 -1.3 228091IPI:IPI00 1 1 3.50% 402 44117 5.3 U Tax_Id=10090 Gene_Symbol=Dctn2 Dynactin subunit 2 * FOXO_KO.2 4.3202 0.2178 99.9 1668.888 1667.885 -0.3 334847.9IPI:IPI00 2 6 3.40% 1288 137611 6.3 U Tax_Id=10090 Gene_Symbol=Oplah 5-oxoprolinase * FOXO_KO.5 5.2694 0.4611 100 3909.994 3907.979 2.2 36284.4* FOXO_KO.1 3.4039 0.3328 100 1172.613 1172.616 -2.2 244379.3IPI:IPI001 1 1 3.40% 1015 113018 9 U Tax_Id=10090 Gene_Symbol=Lig3 Isoform Alpha of DNA ligase 3 IPI:IPI00 1 1 3.40% 1015 113072 9 U Tax_Id=10090 Gene_Symbol=Lig3 113 kDa protein IPI:IPI00 1 1 3.50% 1012 112781 9 U Tax_Id=10090 Gene_Symbol=Lig3 DNA ligase (ATP) 3 IPI:IPI00 1 1 3.70% 956 106428 9.2 U Tax_Id=10090 Gene_Symbol=Lig3 DNA ligase IPI:IPI002 1 1 3.70% 956 106374 9.2 U Tax_Id=10090 Gene_Symbol=Lig3 Isoform Beta of DNA ligase 3

FOXO_KO.1 5.3378 0.4053 100 3299.439 3297.445 -3.8 42031.4IPI:IPI00 1 1 3.40% 861 94045 5.4 U Tax_Id=10090 Gene_Symbol=Zbtb10 zinc finger and BTB domain containing 10 * FOXO_KO.1 3.6204 0.2879 99.8 2744.223 2743.219 0.2 44605.8IPI:IPI00 1 1 3.40% 641 70600 6.2 U Tax_Id=10090 Gene_Symbol=Wdr26 WD repeat-containing protein 26 IPI:IPI00 1 1 4.30% 514 58563 6.2 U Tax_Id=10090 Gene_Symbol=LOC100045629;Wdr26 WD repeat domain 26 IPI:IPI00 1 1 4.40% 498 56899 6.2 U Tax_Id=10090 Gene_Symbol=LOC100045629 similar to myocardial ischemic preconditioning upregulated protein 2 isoform 1

FOXO_KO.2 4.6507 0.3521 100 2563.098 2562.091 1.3 30990.2IPI:IPI00 1 1 3.40% 642 67942 8.6 U Tax_Id=10090 Gene_Symbol=Dlat Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial * FOXO_KO.3 6.0873 0.5359 100 2459.292 2458.29 -0.5 112038.2IPI:IPI00 1 1 3.40% 596 66415 8.5 U Tax_Id=10090 Gene_Symbol=Chdh Choline dehydrogenase, mitochondrial IPI:IPI00 1 1 4.00% 495 54330 8.2 U Tax_Id=10090 Gene_Symbol=Chdh Putative uncharacterized protein

FOXO_KO.2 3.5767 0.2188 99.8 2385.117 2384.115 -0.6 84567.8IPI:IPI00 1 1 3.40% 560 64809 6.2 U Tax_Id=10090 Gene_Symbol=Nt5c2 Cytosolic purine 5'-nucleotidase IPI:IPI00 1 1 3.20% 586 67704 6.8 U Tax_Id=10090 Gene_Symbol=Nt5c2 5'-nucleotidase, cytosolic II isoform 1 IPI:IPI00 1 1 3.20% 585 67765 6.7 U Tax_Id=10090 Gene_Symbol=Nt5c2 5'-nucleotidase, cytosolic II isoform 2

FOXO_KO.5 6.132 0.491 100 2246.17 2245.164 1.1 69907.4IPI:IPI00 1 2 3.40% 560 62982 8.2 U Tax_Id=10090 Gene_Symbol=Sptlc2 Serine palmitoyltransferase 2 * FOXO_KO.3 5.56 0.47 100 2283.074 2282.071 -0.1 55547.4IPI:IPI00 3 3 3.40% 530 60816 8.3 U Tax_Id=10090 Gene_Symbol=Ugt2b37 MCG131369

FOXO_KO.4 4.2115 0.4106 100 1979.998 1979.996 0.9 69083FOXO_KO.4 4.3605 0.3927 100 1981.002 1979.996 1.3 111805.7FOXO_KO.4 5.6693 0.3764 100 2109.1 2108.091 2.7 137740.2

IPI:IPI00 1 1 3.40% 477 53079 7.4 U Tax_Id=10090 Gene_Symbol=Dtx3l 53 kDa protein IPI:IPI00 1 1 2.30% 691 76579 7.3 U Tax_Id=10090 Gene_Symbol=Dtx3l Isoform 2 of E3 ubiquitin-protein ligase DTX3L IPI:IPI00 1 1 2.10% 748 83044 8.1 U Tax_Id=10090 Gene_Symbol=Dtx3l Isoform 1 of E3 ubiquitin-protein ligase DTX3L

FOXO_KO.3 4.3251 0.4318 100 1912.036 1911.032 0.4 147653.1

IPI:IPI001 1 1 3.40% 445 50537 6.2 U Tax_Id=10090 Gene_Symbol=Gdi2 Isoform 1 of Rab GDP dissociation inhibitor beta IPI:IPI00 1 1 6.50% 230 26260 7.3 U Tax_Id=10090 Gene_Symbol=Gdi2 Putative uncharacterized protein IPI:IPI00 1 1 3.70% 409 46658 6.9 U Tax_Id=10090 Gene_Symbol=Gdi2 Isoform 2 of Rab GDP dissociation inhibitor beta

FOXO_KO.1 4.2693 0.423 100 1899.789 1899.785 2 138162.2IPI:IPI00 1 1 3.40% 384 44538 7 U Tax_Id=10090 Gene_Symbol=LOC100048642 similar to Snx5 protein

FOXO_KO.2 4.4751 0.3232 100 1544.658 1544.657 0.2 313072.4IPI:IPI00 1 3 3.40% 321 35108 9.8 U Tax_Id=10090 Gene_Symbol=Eno1 Enolase IPI:IPI00 1 3 9.20% 119 12936 8.1 U Tax_Id=10090 Gene_Symbol=Eno1 Enolase 1, alpha non-neuron IPI:IPI00 1 3 6.20% 176 19305 8.6 U Tax_Id=10090 Gene_Symbol=LOC100047882 similar to enolase 1, alpha non-neuron

FOXO_KO.1 3.7412 0.4086 100 1280.584 1280.586 -2 228053.6IPI:IPI00 2 2 3.40% 324 33901 5.4 U Tax_Id=10090 Gene_Symbol=Purb Transcriptional activator protein Pur-beta * FOXO_KO.9 3.8285 0.1584 99.8 1411.653 1411.652 0.3 513474.7* FOXO_KO.9 2.8181 0.2363 99.5 1411.651 1411.652 -0.7 342057.8IPI:IPI001 3 4 3.30% 738 82989 6.5 U Tax_Id=10090 Gene_Symbol=Letm1 LETM1 and EF-hand domain-containing protein 1, mitochondrial * FOXO_KO.3 4.6871 0.2857 99.9 2824.396 2822.383 2.4 74204.3* FOXO_KO.3 5.9168 0.4625 100 2951.481 2950.478 0.1 92865.3* FOXO_KO.3 4.2725 0.2771 99.9 2951.48 2950.478 -0.3 208564IPI:IPI001 2 2 3.30% 693 75332 8.3 U Tax_Id=10090 Gene_Symbol=Tmpo Isoform Alpha of Lamina-associated polypeptide 2, isoforms alpha/zeta IPI:IPI007 2 2 10.20% 225 24950 8.7 U Tax_Id=10090 Gene_Symbol=Tmpo Isoform Zeta of Lamina-associated polypeptide 2, isoforms alpha/zeta IPI:IPI006 2 2 6.70% 343 38423 9.1 U Tax_Id=10090 Gene_Symbol=Tmpo Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma IPI:IPI00 2 2 6.10% 380 42572 9.4 U Tax_Id=10090 Gene_Symbol=Tmpo Isoform Delta of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma IPI:IPI004 2 2 5.60% 412 45972 9.1 U Tax_Id=10090 Gene_Symbol=Tmpo Isoform Epsilon of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma IPI:IPI00 2 2 8.30% 277 30514 10.1 U Tax_Id=10090 Gene_Symbol=Tmpo Putative uncharacterized protein (Fragment) IPI:IPI003 2 2 5.10% 452 50295 9.4 U Tax_Id=10090 Gene_Symbol=Tmpo Isoform Beta of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

FOXO_KO.3 6.53 0.5165 100 2702.346 2701.341 0.4 26615.9FOXO_KO.3 4.3467 0.2526 99.9 2702.345 2701.341 0 129704

IPI:IPI00 2 2 3.30% 674 74253 6.2 U Tax_Id=10090 Gene_Symbol=Fxr2 Putative uncharacterized protein IPI:IPI00 2 2 3.30% 673 73743 6.2 U Tax_Id=10090 Gene_Symbol=Fxr2 Fragile X mental retardation syndrome-related protein 2 IPI:IPI00 2 2 3.40% 655 70529 6.9 U Tax_Id=10090 Gene_Symbol=Fxr2 Putative uncharacterized protein (Fragment)

FOXO_KO.1 3.3727 0.399 99.9 2522.213 2521.209 0.1 152692.5FOXO_KO.1 4.0281 0.4199 100 1525.7 1525.702 -1.4 182006

IPI:IPI003 1 2 3.30% 598 67442 9.5 U Tax_Id=10090 Gene_Symbol=Ddx52 Probable ATP-dependent RNA helicase DDX52 FOXO_KO.3 5.4363 0.5089 100 2139.084 2137.066 5.3 79781.7

IPI:IPI00 3 4 3.30% 580 61767 7.8 U Tax_Id=10090 Gene_Symbol=Krt5 Keratin, type II cytoskeletal 5 IPI:IPI00 3 4 3.40% 563 60362 7.8 U Tax_Id=10090 Gene_Symbol=Krt5 60 kDa protein

FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715FOXO_KO_w 2.3764 0.3478 100 1079.513 1079.512 1.5 20194.2

IPI:IPI00 1 1 3.30% 541 60575 6.1 U Tax_Id=10090 Gene_Symbol=Atl3 Isoform 1 of Atlastin-3 IPI:IPI00 1 1 3.40% 536 60232 5.8 U Tax_Id=10090 Gene_Symbol=Atl3 atlastin GTPase 3 isoform 1

FOXO_KO.3 5.0579 0.4946 100 2393.102 2392.101 -1 158861IPI:IPI00 1 1 3.30% 492 56179 9.2 U Tax_Id=10090 Gene_Symbol=Cyp2a12 MCG133379, isoform CRA_a IPI:IPI003 1 1 3.30% 492 56173 9.2 U Tax_Id=10090 Gene_Symbol=Cyp2a12 Cytochrome P450 2A12

FOXO_KO.1 4.2107 0.3815 100 1832.902 1832.903 -0.5 168426.6IPI:IPI00 1 1 3.30% 486 55833 5.2 U Tax_Id=10090 Gene_Symbol=Pacsin2 Protein kinase C and casein kinase substrate in neurons protein 2 * FOXO_KO.1 3.7191 0.4139 100 1943.86 1943.866 -3.1 86710.8IPI:IPI00 1 1 3.30% 479 53076 6.7 U Tax_Id=10090 Gene_Symbol=Grsf1 G-rich sequence factor 1 IPI:IPI00 1 1 4.40% 362 41610 5.3 U Tax_Id=10090 Gene_Symbol=Grsf1 G-rich RNA sequence binding factor 1 isoform 2

FOXO_KO.1 5.6273 0.4777 100 1848.881 1847.88 -1.7 153595IPI:IPI00 1 1 3.30% 450 50037 5.1 U Tax_Id=10090 Gene_Symbol=Gm5620 similar to Tubulin, alpha 3c isoform 1 IPI:IPI006 1 1 3.60% 418 46149 5.1 U Tax_Id=10090 Gene_Symbol=Gm5620 similar to Tubulin, alpha 3c isoform 3

FOXO_KO.3 4.3256 0.3804 100 1701.906 1701.906 -0.1 280178.4IPI:IPI00 1 1 3.30% 456 49817 4.8 U Tax_Id=10090 Gene_Symbol=Rnh1 Ribonuclease inhibitor IPI:IPI00 1 1 3.00% 492 53926 5 U Tax_Id=10090 Gene_Symbol=Rnh1 ribonuclease inhibitor isoform b

FOXO_KO.1 4.4203 0.4748 100 1631.822 1631.824 -0.7 172804.1IPI:IPI00 1 1 3.30% 270 25287 8.8 U Tax_Id=10090 Gene_Symbol=Krt2 Keratin (Fragment) IPI:IPI00 1 1 1.30% 701 70679 8.3 U Tax_Id=10090 Gene_Symbol=Krt2 71 kDa protein IPI:IPI00 1 1 1.30% 707 70923 8.1 U Tax_Id=10090 Gene_Symbol=Krt2 Keratin, type II cytoskeletal 2 epidermal

FOXO_KO.1 3.1193 0.3414 100 1142.524 1141.519 0.9 524535.2IPI:IPI00 5 5 3.20% 2602 277750 5.7 U Tax_Id=10090 Gene_Symbol=Flnb Filamin-B

FOXO_KO.1 2.6447 0.244 99.6 1172.592 1172.595 -2.3 267286.7* FOXO_KO.3 3.9142 0.2552 99.7 3041.424 3040.42 0.1 94987.5* FOXO_KO.1 3.5857 0.3346 100 1173.61 1173.611 -1.2 221399.4* FOXO_KO.1 5.2222 0.3875 100 2125.086 2125.088 -1 73019* FOXO_KO.1 3.8845 0.4328 100 1622.725 1622.721 2 198759.2IPI:IPI001 2 2 3.20% 1265 146409 8.8 U Tax_Id=10090 Gene_Symbol=Myo6 Myosin-VI IPI:IPI00 2 2 3.20% 1260 145982 8.9 U Tax_Id=10090 Gene_Symbol=Myo6 146 kDa protein

FOXO_KO.3 6.5931 0.5218 100 2266.07 2265.07 -1.5 134943.4FOXO_KO.2 6.4712 0.6022 100 2191.034 2190.034 -1.6 104941.8

IPI:IPI00 1 1 3.20% 959 106983 4.9 U Tax_Id=10090 Gene_Symbol=Uso1 Isoform 1 of General vesicular transport factor p115 IPI:IPI00 1 1 3.50% 897 100195 5 U Tax_Id=10090 Gene_Symbol=Uso1 Isoform 2 of General vesicular transport factor p115 IPI:IPI006 1 1 6.20% 496 54732 5.3 U Tax_Id=10090 Gene_Symbol=Uso1 Isoform 3 of General vesicular transport factor p115

FOXO_KO.5 6.8682 0.4864 100 3577.647 3575.639 0.2 103442.3IPI:IPI003 1 1 3.20% 894 99099 7.6 U Tax_Id=10090 Gene_Symbol=Mttp Isoform 1 of Microsomal triglyceride transfer protein large subunit IPI:IPI009 1 1 3.20% 909 100751 7.6 U Tax_Id=10090 Gene_Symbol=Mttp Isoform 2 of Microsomal triglyceride transfer protein large subunit

FOXO_KO.5 3.7976 0.2776 99.8 3175.655 3174.646 1.9 24461.2IPI:IPI00 1 2 3.20% 715 79672 5.1 U Tax_Id=10090 Gene_Symbol=Slc4a1ap solute carrier family 4 (anion exchanger), member 1, adaptor protein IPI:IPI00 1 2 4.30% 534 59410 5.2 U Tax_Id=10090 Gene_Symbol=Slc4a1ap Slc4a1ap protein IPI:IPI00 1 2 3.10% 744 82887 5 U Tax_Id=10090 Gene_Symbol=Slc4a1ap 83 kDa protein IPI:IPI00 1 2 4.50% 507 57628 5 U Tax_Id=10090 Gene_Symbol=Slc4a1ap Kanadaptin

FOXO_KO.2 4.2027 0.2935 99.9 2647.372 2645.367 -0.7 206647.1IPI:IPI00 1 1 3.20% 686 74991 7.4 U Tax_Id=10090 Gene_Symbol=Dll4 delta-like 4 precursor * FOXO_KO.5 4.0291 0.3561 99.9 2619.027 2618.023 0.3 43449.7IPI:IPI007 1 1 3.20% 621 70291 7.6 U Tax_Id=10090 Gene_Symbol=Papss2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 IPI:IPI00 1 1 3.20% 621 70351 7.6 U Tax_Id=10090 Gene_Symbol=Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2

FOXO_KO.1 5.8941 0.5173 100 2286.07 2285.064 1.2 67054IPI:IPI00 1 1 3.20% 539 58066 8 U Tax_Id=10090 Gene_Symbol=Cct4 T-complex protein 1 subunit delta * FOXO_KO.2 5.1225 0.4722 100 2000.867 2000.869 -0.9 88607.7IPI:IPI00 1 1 3.20% 502 55456 9.2 U Tax_Id=10090 Gene_Symbol=Slc7a11 Cystine/glutamate transporter * FOXO_KO.3 3.159 0.337 99.9 1826.018 1826.016 1.1 117203.7IPI:IPI00 4 15 3.20% 505 53649 5.5 U Tax_Id=10090 Gene_Symbol=Foxo4 Forkhead box protein O4 IPI:IPI00 4 15 3.60% 450 47965 5.3 U Tax_Id=10090 Gene_Symbol=Foxo4 Forkhead box O4 IPI:IPI00 4 15 5.80% 277 29645 9.2 U Tax_Id=10090 Gene_Symbol=Foxo3 Foxo3 protein (Fragment) IPI:IPI00 4 15 2.40% 672 71064 5.1 U Tax_Id=10090 Gene_Symbol=Foxo3 Forkhead box O3a

FOXO_KO.1 3.0161 0.3618 100 1251.558 1251.56 -1.6 87628.9FOXO_KO.1 3.8266 0.3195 100 1251.558 1251.56 -1.6 2042793

FOXO_KO_w 5.1297 0.3394 100 1721.82 1721.82 -0.4 34864.6FOXO_KO_w 4.1223 0.2673 99.9 1801.79 1801.786 2.2 17309.1

IPI:IPI001 1 2 3.20% 469 53399 5.5 U Tax_Id=10090 Gene_Symbol=Utp3 Isoform 1 of Something about silencing protein 10 IPI:IPI005 1 2 3.60% 413 46544 4.8 U Tax_Id=10090 Gene_Symbol=Utp3 Isoform 2 of Something about silencing protein 10

FOXO_KO.4 5.1967 0.3658 100 1726.911 1726.911 -0.1 110957.1IPI:IPI001 1 1 3.20% 441 49014 5.8 U Tax_Id=10090 Gene_Symbol=Ddost Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit IPI:IPI00 1 1 3.20% 441 49028 5.8 U Tax_Id=10090 Gene_Symbol=Ddost Putative uncharacterized protein

FOXO_KO.1 3.7252 0.4145 100 1641.692 1641.695 -1.9 158908.2IPI:IPI00 1 1 3.20% 374 41848 6.4 U Tax_Id=10090 Gene_Symbol=H2-K1 42 kDa protein IPI:IPI009 1 1 3.30% 362 40772 6.3 U Tax_Id=10090 Gene_Symbol=LOC676708 similar to class I (Qa) Q2k antigen IPI:IPI00 1 1 7.60% 158 18157 5.6 U Tax_Id=10090 Gene_Symbol=Gm8810 MHC class I antigen (Fragment) IPI:IPI00 1 1 4.10% 292 33192 6.6 U Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t 33 kDa protein IPI:IPI00 1 1 6.00% 200 23255 7 U Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t 23 kDa protein IPI:IPI00 1 1 3.60% 333 37412 7.6 U Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t 37 kDa protein IPI:IPI00 1 1 3.30% 369 41302 6.4 U Tax_Id=10090 Gene_Symbol=H2-K1 H-2 class I histocompatibility antigen, K-B alpha chain IPI:IPI00 1 1 3.30% 362 40755 6.6 U Tax_Id=10090 Gene_Symbol=H2-Q2 Class I (Qa) Q2k antigen IPI:IPI00 1 1 4.40% 270 30882 6.2 U Tax_Id=10090 Gene_Symbol=H2-K1 MHC class Ia H2-K antigen (Fragment) IPI:IPI00 1 1 3.30% 368 41334 6.1 U Tax_Id=10090 Gene_Symbol=H2-K1 mRNA IPI:IPI00 1 1 3.30% 362 40476 6 U Tax_Id=10090 Gene_Symbol=H2-Q7 40 kDa protein IPI:IPI007 1 1 6.00% 200 23025 5.6 U Tax_Id=10090 Gene_Symbol=H2-Q9 H-2 class I histocompatibility antigen, Q9 alpha chain (Fragment) IPI:IPI00 1 1 3.40% 353 39676 5.4 U Tax_Id=10090 Gene_Symbol=LOC676689 MHC class I D-region cell surface antigen (Fragment) IPI:IPI00 1 1 3.40% 349 40065 6.1 U Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t similar to class Ib MHC antigen Qa-2 isoform 2 IPI:IPI00 1 1 4.30% 277 30921 6.4 U Tax_Id=10090 Gene_Symbol=H2-K1 MHC class I H2-K-b gene IPI:IPI00 1 1 3.40% 357 39643 7.5 U Tax_Id=10090 Gene_Symbol=H2-K1 40 kDa protein IPI:IPI00 1 1 3.70% 328 37391 6 U Tax_Id=10090 Gene_Symbol=H2-Q8 MHC class I Q8/9d cell surface antigen (Fragment) IPI:IPI00 1 1 5.70% 209 24277 6.1 U Tax_Id=10090 Gene_Symbol=C920025E04Rik C920025E04Rik protein IPI:IPI005 1 1 3.70% 326 37411 5.9 U Tax_Id=10090 Gene_Symbol=H2-Q8 H-2 class I histocompatibility antigen, Q8 alpha chain IPI:IPI00 1 1 3.70% 326 37407 6.2 U Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t Class Ib MHC antigen Qa-2 IPI:IPI00 1 1 3.50% 344 38855 7.3 U Tax_Id=10090 Gene_Symbol=H2-D1 MRNA, IPI:IPI00 1 1 3.50% 342 39365 6.4 U Tax_Id=10090 Gene_Symbol=H2-T23 Qa-1 IPI:IPI00 1 1 3.30% 362 40828 6.4 U Tax_Id=10090 Gene_Symbol=H2-K1 MHC class I heavy chain H2-K IPI:IPI00 1 1 3.30% 360 40410 7.2 U Tax_Id=10090 Gene_Symbol=H2-K1 MHC H-2K antigen IPI:IPI00 1 1 6.50% 184 21152 5.6 U Tax_Id=10090 Gene_Symbol=H2-Q8 histocompatibility 2, Q region locus 8 IPI:IPI00 1 1 3.60% 334 37924 6.3 U Tax_Id=10090 Gene_Symbol=H2-Q7 H-2 class I histocompatibility antigen, Q7 alpha chain IPI:IPI00 1 1 3.30% 369 41823 6 U Tax_Id=10090 Gene_Symbol=H2-K1 MRNA, IPI:IPI00 1 1 3.30% 362 40620 5.5 U Tax_Id=10090 Gene_Symbol=H2-D1 H-2 class I histocompatibility antigen, D-K alpha chain

FOXO_KO.2 3.8971 0.3159 100 1639.683 1639.685 -0.8 264533.7IPI:IPI00 1 1 3.20% 317 35077 7.7 U Tax_Id=10090 Gene_Symbol=Gnb2l1 Guanine nucleotide-binding protein subunit beta-2-like 1 * FOXO_KO.9 2.5012 0.2954 99.8 1193.566 1192.559 3 769586.1IPI:IPI00 1 1 3.10% 1233 139410 7.6 U Tax_Id=10090 Gene_Symbol=Copa Putative uncharacterized protein * FOXO_KO.3 3.6053 0.2941 99.8 4145.008 4145.008 0 136029.3IPI:IPI00 1 1 3.10% 1001 113882 8.4 U Tax_Id=10090 Gene_Symbol=Dhx36 Probable ATP-dependent RNA helicase DHX36 * FOXO_KO.5 3.8877 0.3628 99.9 3705.809 3704.805 0 29029.5IPI:IPI00 1 2 3.10% 986 113672 6.2 U Tax_Id=10090 Gene_Symbol=Rbm6 RNA binding motif protein 6 isoform b

FOXO_KO.2 5.996 0.4264 100 3407.537 3405.535 -1.5 107932.8IPI:IPI003 2 3 3.10% 850 97431 7.1 U Tax_Id=10090 Gene_Symbol=Pygl Glycogen phosphorylase, liver form IPI:IPI00 2 3 3.40% 759 86514 6.2 U Tax_Id=10090 Gene_Symbol=Pygl Phosphorylase IPI:IPI00 2 3 3.10% 850 97463 7.1 U Tax_Id=10090 Gene_Symbol=Pygl liver glycogen phosphorylase

FOXO_KO.2 4.2958 0.4705 100 1632.727 1632.729 -1 258938.6FOXO_KO.1 4.4535 0.3019 100 1597.755 1596.754 -1.6 235712.2

IPI:IPI00 1 2 3.10% 846 94630 6.3 U Tax_Id=10090 Gene_Symbol=Matr3 Matrin-3 * FOXO_KO.3 4.5358 0.3982 99.9 3081.654 3080.651 -0.4 76738.5IPI:IPI00 1 1 3.10% 716 83384 5.4 U Tax_Id=10090 Gene_Symbol=Hook2 Protein Hook homolog 2 IPI:IPI00 1 1 3.10% 715 83295 5.4 U Tax_Id=10090 Gene_Symbol=Hook2 hook homolog 2 isoform 2 IPI:IPI00 1 1 3.20% 692 80492 5.3 U Tax_Id=10090 Gene_Symbol=Hook2 Putative uncharacterized protein IPI:IPI00 1 1 3.10% 716 83366 5.4 U Tax_Id=10090 Gene_Symbol=Hook2 hook homolog 2 isoform 1

FOXO_KO.5 3.3374 0.2403 99.5 2561.293 2559.287 -0.1 106477.7IPI:IPI00 1 2 3.10% 422 47437 6.5 U Tax_Id=10090 Gene_Symbol=Psmd11 26S proteasome non-ATPase regulatory subunit 11 * FOXO_KO.1 3.4661 0.364 100 1516.713 1516.713 0.2 157806.4IPI:IPI00 1 1 3.10% 418 46035 6.2 U Tax_Id=10090 Gene_Symbol=Gm13050 similar to Eukaryotic translation elongation factor 2

FOXO_KO.1 4.1056 0.3788 100 1567.775 1567.778 -1.9 194277.4IPI:IPI00 1 1 3.10% 320 34395 9.5 U Tax_Id=10090 Gene_Symbol=Gm5803 predicted gene 5803

FOXO_KO.2 3.6829 0.4008 100 1218.637 1218.64 -2 309989.5IPI:IPI00 2 2 3.00% 1588 175049 7.2 U Tax_Id=10090 Gene_Symbol=Cep170 Isoform 1 of Centrosomal protein of 170 kDa * FOXO_KO.1 4.9529 0.3208 99.9 3352.603 3351.603 -1.2 41599.4

FOXO_KO.1 3.5927 0.4356 100 1617.67 1616.671 -2.5 206511.3IPI:IPI00 2 3 3.00% 1038 119486 4.8 U Tax_Id=10090 Gene_Symbol=Ipo7 Importin-7 * FOXO_KO.1 3.9315 0.3189 100 1518.727 1518.728 -0.7 191471.5* FOXO_KO.2 7.2843 0.5374 100 2141.993 2140.992 -1 75063.9IPI:IPI00 1 2 3.00% 1096 118581 6.8 U Tax_Id=10090 Gene_Symbol=Sec24c Sec24 related gene family, member C isoform 1 IPI:IPI00 1 2 3.20% 1020 111613 6.7 U Tax_Id=10090 Gene_Symbol=Sec24c Sec24 related gene family, member C isoform 2

FOXO_KO.6 4.8078 0.4581 100 3583.78 3581.769 1.3 38040.7IPI:IPI001 1 1 3.00% 963 109549 6.3 U Tax_Id=10090 Gene_Symbol=Kif5b Kinesin-1 heavy chain IPI:IPI00 1 1 3.00% 963 109551 6.4 U Tax_Id=10090 Gene_Symbol=Kif5b kinesin family member 5B

FOXO_KO.4 5.7359 0.5071 100 3305.668 3303.659 0.6 124192.5IPI:IPI002 1 1 3.00% 695 77646 8.7 U Tax_Id=10090 Gene_Symbol=Ptcd1 Pentatricopeptide repeat-containing protein 1 IPI:IPI00 1 1 3.00% 695 77594 8.8 U Tax_Id=10090 Gene_Symbol=Ptcd1 pentatricopeptide repeat domain 1 IPI:IPI00 1 1 3.00% 695 77680 8.8 U Tax_Id=10090 Gene_Symbol=Ptcd1 Putative uncharacterized protein

FOXO_KO.2 4.2906 0.3798 100 2196.035 2195.035 -1.5 45501.4IPI:IPI00 1 1 3.00% 624 71559 6 U Tax_Id=10090 Gene_Symbol=Parn Poly(A)-specific ribonuclease PARN * FOXO_KO.4 3.8178 0.3066 99.9 2367.231 2366.224 1.7 178931.1IPI:IPI00 1 1 3.00% 627 70149 5.3 U Tax_Id=10090 Gene_Symbol=Lcp1 Plastin-2 IPI:IPI00 1 1 15.70% 121 13247 5.3 U Tax_Id=10090 Gene_Symbol=Lcp1 13 kDa protein IPI:IPI00 1 1 25.00% 76 8497 4.4 U Tax_Id=10090 Gene_Symbol=Lcp1 8 kDa protein IPI:IPI00 1 1 18.80% 101 11284 5.1 U Tax_Id=10090 Gene_Symbol=Lcp1 11 kDa protein IPI:IPI00 1 1 18.30% 104 11525 5.1 U Tax_Id=10090 Gene_Symbol=Lcp1 12 kDa protein

FOXO_KO.3 3.2071 0.3437 99.9 2175.995 2173.971 8 48290.3IPI:IPI00 1 1 3.00% 525 60181 5.1 U Tax_Id=10090 Gene_Symbol=Acbd3 Golgi resident protein GCP60 * FOXO_KO.2 5.1688 0.4604 100 1696.845 1695.844 -0.9 167664.4IPI:IPI00 1 2 3.00% 501 58842 5.3 U Tax_Id=10090 Gene_Symbol=Sf3a3 Splicing factor 3A subunit 3 * FOXO_KO.4 5.7908 0.4227 100 1965.928 1964.931 -3.3 101828.3IPI:IPI00 2 2 3.00% 463 50454 9 U Tax_Id=10090 Gene_Symbol=Eef1a2 Elongation factor 1-alpha 2

FOXO_KO.1 4.7207 0.4242 100 1611.81 1610.809 -1.8 257581.1FOXO_KO.1 2.9504 0.3486 99.9 1610.807 1610.809 -1.3 232010.8

IPI:IPI00 1 2 3.00% 436 48740 9.9 U Tax_Id=10090 Gene_Symbol=Stau1 Staufen FOXO_KO.1 2.9672 0.2596 99.6 1665.852 1665.852 0.4 257953.6

IPI:IPI00 1 1 3.00% 394 45276 6.9 U Tax_Id=10090 Gene_Symbol=Prmt8 Protein arginine N-methyltransferase 8 IPI:IPI00 1 1 4.70% 255 29038 6 U Tax_Id=10090 Gene_Symbol=Prmt1 Putative uncharacterized protein

FOXO_KO.1 3.9555 0.4197 100 1355.741 1355.742 -0.7 196461IPI:IPI00 1 1 3.00% 394 44761 6.7 U Tax_Id=10090 Gene_Symbol=Actr2 Actin-related protein 2 IPI:IPI00 1 1 3.60% 330 37322 6.8 U Tax_Id=10090 Gene_Symbol=Actr2 Putative uncharacterized protein

FOXO_KO.1 3.5464 0.3994 100 1335.627 1334.626 -1.5 333150IPI:IPI00 1 2 3.00% 330 35744 8.7 U Tax_Id=10090 Gene_Symbol=- similar to Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

FOXO_KO.1 3.1789 0.2756 99.9 1211.592 1211.594 -1.6 236144IPI:IPI001 1 1 2.90% 897 101163 11.9 U Tax_Id=10090 Gene_Symbol=Srrm1 Isoform 2 of Serine/arginine repetitive matrix protein 1 IPI:IPI00 1 1 8.20% 318 34677 12.4 U Tax_Id=10090 Gene_Symbol=Srrm1 Serine/arginine repetitive matrix 1 IPI:IPI00 1 1 2.80% 918 103715 11.9 U Tax_Id=10090 Gene_Symbol=Srrm1 serine/arginine repetitive matrix 1 isoform 2 IPI:IPI006 1 1 2.70% 946 106892 11.9 U Tax_Id=10090 Gene_Symbol=Srrm1 Isoform 1 of Serine/arginine repetitive matrix protein 1

FOXO_KO.1 3.41 0.3349 99.9 2764.387 2763.387 -1.1 62646.9IPI:IPI003 1 1 2.90% 793 89520 6.7 U Tax_Id=10090 Gene_Symbol=1810074P20Rik Isoform 1 of E3 UFM1-protein ligase 1 IPI:IPI006 1 1 7.30% 317 36084 6.4 U Tax_Id=10090 Gene_Symbol=1810074P20Rik Isoform 3 of E3 UFM1-protein ligase 1 IPI:IPI006 1 1 3.20% 713 80220 6.7 U Tax_Id=10090 Gene_Symbol=1810074P20Rik Isoform 2 of E3 UFM1-protein ligase 1

FOXO_KO.5 6.3934 0.5395 100 2698.42 2697.413 1.2 74091.7IPI:IPI00 1 1 2.90% 750 84204 9.5 U Tax_Id=10090 Gene_Symbol=Rbm28 RNA-binding protein 28 * FOXO_KO.4 4.3966 0.4093 100 2468.19 2468.183 3.2 79400.4IPI:IPI001 1 1 2.90% 618 70301 8.6 U Tax_Id=10090 Gene_Symbol=Nxf1 Nuclear RNA export factor 1 IPI:IPI00 1 1 2.90% 618 70300 8.7 U Tax_Id=10090 Gene_Symbol=Nxf1 Nuclear RNA export factor 1 homolog (S. cerevisiae), isoform CRA_b

FOXO_KO.1 4.9647 0.5432 100 2006.802 2006.803 -0.4 112891.5IPI:IPI00 1 1 2.90% 623 69037 7.9 U Tax_Id=10090 Gene_Symbol=Rpa1 Replication protein A 70 kDa DNA-binding subunit IPI:IPI00 1 1 2.80% 644 71414 8.2 U Tax_Id=10090 Gene_Symbol=Rpa1 replication protein A1 isoform 1

FOXO_KO.2 3.4816 0.3235 99.9 1996.96 1996.961 -0.7 113297.5IPI:IPI00 2 4 2.90% 577 67767 6.6 U Tax_Id=10090 Gene_Symbol=Msn Moesin * FOXO_KO.4 5.8369 0.4538 100 2084.012 2082.002 1.3 79855.7* FOXO_KO.4 2.9538 0.3143 99.8 2083.006 2082.002 0 119211IPI:IPI00 2 2 2.90% 591 64125 5.8 U Tax_Id=10090 Gene_Symbol=Hnrpll Isoform 1 of Heterogeneous nuclear ribonucleoprotein L-like IPI:IPI00 2 2 7.00% 244 24835 4.6 U Tax_Id=10090 Gene_Symbol=- Putative uncharacterized protein (Fragment) IPI:IPI005 2 2 5.20% 326 34938 4.7 U Tax_Id=10090 Gene_Symbol=Hnrpll Isoform 2 of Heterogeneous nuclear ribonucleoprotein L-like

FOXO_KO.3 5.287 0.4156 100 1861.932 1860.926 1.7 159304.7FOXO_KO.3 4.8082 0.3568 100 1861.929 1860.926 0 183973.2

IPI:IPI00 1 2 2.90% 547 63530 6.2 U Tax_Id=10090 Gene_Symbol=Eif3d 64 kDa protein FOXO_KO.2 5.1051 0.3214 99.9 2012.916 2011.914 -0.8 127425.8

IPI:IPI00 1 1 2.90% 478 54849 5.9 U Tax_Id=10090 Gene_Symbol=Vtn Vitronectin * FOXO_KO.5 3.3593 0.3611 100 1811.877 1811.875 1.1 52479.6IPI:IPI00 1 1 2.90% 453 51958 6.5 U Tax_Id=10090 Gene_Symbol=Ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform IPI:IPI00 1 1 2.80% 457 52353 6.6 U Tax_Id=10090 Gene_Symbol=Ppp2r2d Protein

FOXO_KO.1 3.6018 0.2533 99.9 1509.743 1509.743 -0.3 209687.9IPI:IPI003 2 4 2.80% 1384 149689 6.8 U Tax_Id=10090 Gene_Symbol=Dhx9 Isoform 2 of ATP-dependent RNA helicase A * FOXO_KO.1 5.9841 0.4781 100 2369.014 2367.012 -2 96213.3

FOXO_KO.2 5.2781 0.3062 100 1743.865 1741.86 -0.9 152809IPI:IPI00 2 2 2.80% 1284 145413 6.3 U Tax_Id=10090 Gene_Symbol=Bms1 BMS1-like, ribosome assembly protein * FOXO_KO.1 4.65 0.3587 100 1638.769 1638.772 -1.6 159600.3* FOXO_KO.3 3.7789 0.2893 99.9 2551.169 2551.172 -1.3 271448.8IPI:IPI00 1 1 2.80% 776 89691 8 U Tax_Id=10090 Gene_Symbol=Cul1 Cullin-1 IPI:IPI00 1 1 3.10% 699 80589 7.3 U Tax_Id=10090 Gene_Symbol=Cul1 Putative uncharacterized protein

FOXO_KO.4 4.1631 0.2931 99.9 2507.236 2507.233 0.9 155760.4IPI:IPI00 1 1 2.80% 746 84187 9.2 U Tax_Id=10090 Gene_Symbol=Dpy19l1 Isoform 1 of Protein dpy-19 homolog 1 * FOXO_KO.1 4.5657 0.5389 100 2041.963 2041.967 -1.9 43672.5IPI:IPI003 1 1 2.80% 671 74657 9.2 U Tax_Id=10090 Gene_Symbol=Srp72 signal recognition particle 72 IPI:IPI00 1 1 3.10% 610 67929 9.4 U Tax_Id=10090 Gene_Symbol=Srp72 Putative uncharacterized protein

FOXO_KO.4 5.5816 0.4678 100 2113.117 2113.117 -0.3 139433.7IPI:IPI001 1 2 2.80% 634 71772 8.3 U Tax_Id=10090 Gene_Symbol=Trim25 E3 ubiquitin/ISG15 ligase TRIM25 IPI:IPI00 1 2 2.80% 634 71802 8.3 U Tax_Id=10090 Gene_Symbol=- Tripartite motif protein 25 IPI:IPI00 1 2 2.90% 626 70830 8.1 U Tax_Id=10090 Gene_Symbol=- Tripartite motif protein 25 IPI:IPI00 1 2 4.70% 387 44225 7.9 U Tax_Id=10090 Gene_Symbol=- Tripartite motif protein 25 IPI:IPI00 1 2 2.90% 626 70754 8.1 U Tax_Id=10090 Gene_Symbol=Trim25 Tripartite motif protein 25 IPI:IPI00 1 2 3.00% 601 68468 8.3 U Tax_Id=10090 Gene_Symbol=Trim25 Putative uncharacterized protein IPI:IPI00 1 2 2.80% 634 71726 8.3 U Tax_Id=10090 Gene_Symbol=Trim25 tripartite motif protein 25

FOXO_KO.3 7.3489 0.4121 100 2144.033 2142.031 -2 94851.5IPI:IPI00 2 2 2.80% 640 68161 8.3 U Tax_Id=10090 Gene_Symbol=Hnrnpm Heterogeneous nuclear ribonucleoprotein M IPI:IPI00 2 2 2.70% 679 72069 8.1 U Tax_Id=10090 Gene_Symbol=Hnrnpm Heterogeneous nuclear ribonucleoprotein M

FOXO_KO.3 3.5608 0.3175 99.9 2011.013 2010.01 -0.3 134746.1FOXO_KO.3 6.139 0.4822 100 1753.878 1752.872 1.4 165198.4

IPI:IPI00 1 1 2.80% 581 63660 6.3 U Tax_Id=10090 Gene_Symbol=Hacl1 2-hydroxyacyl-CoA lyase 1 * FOXO_KO.2 4.3137 0.4663 100 1711.797 1711.796 0.6 124303.3IPI:IPI00 1 1 2.80% 539 58862 7.5 U Tax_Id=10090 Gene_Symbol=Aldh7a1 aldehyde dehydrogenase 7 family, member A1 isoform a IPI:IPI00 1 1 2.90% 511 55645 6.4 U Tax_Id=10090 Gene_Symbol=Aldh7a1 Alpha-aminoadipic semialdehyde dehydrogenase

FOXO_KO.2 5.5165 0.4277 100 1943.855 1941.85 -1.1 516094.2IPI:IPI00 2 3 2.80% 493 56805 8.4 U Tax_Id=10090 Gene_Symbol=Cyp2e1 Cytochrome P450 2E1 * FOXO_KO.2 3.3903 0.3331 100 1465.691 1465.691 -0.4 175573.4* FOXO_KO.2 4.7464 0.3758 100 1722.827 1722.829 -0.9 174710.5IPI:IPI00 1 1 2.80% 463 51113 5.6 U Tax_Id=10090 Gene_Symbol=Ruvbl2 RuvB-like 2 IPI:IPI00 1 1 5.90% 221 23527 8.9 U Tax_Id=10090 Gene_Symbol=Ruvbl2 24 kDa protein

FOXO_KO.1 4.3735 0.4293 100 1402.761 1401.758 -0.5 209557.1contamina 1 1 2.80% 431 47974 5 U no description

FOXO_KO.1 4.1804 0.3014 100 1345.684 1345.685 -0.6 200397.3IPI:IPI00 4 6 2.70% 2477 272487 5.6 U Tax_Id=10090 Gene_Symbol=Fn1 Fibronectin

FOXO_KO.1 5.2374 0.5019 100 2074.85 2073.853 -3.1 102943.1FOXO_KO.1 4.6938 0.4637 100 2197.93 2196.925 0.6 76157.9FOXO_KO.1 4.6145 0.4601 100 2196.92 2196.925 -2.2 233079.6FOXO_KO.3 3.0528 0.2843 99.5 3646.765 3646.765 0.2 39536.6

IPI:IPI00 1 1 2.70% 919 101682 6.7 U Tax_Id=10090 Gene_Symbol=Sardh Sarcosine dehydrogenase, mitochondrial IPI:IPI00 1 1 4.90% 507 57286 6.9 U Tax_Id=10090 Gene_Symbol=Sardh Sarcosine dehydrogenase

FOXO_KO.4 4.594 0.311 99.9 2845.421 2843.421 -2.3 115257.6IPI:IPI00 1 1 2.70% 819 95495 9.6 U Tax_Id=10090 Gene_Symbol=Ddx23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 * FOXO_KO.1 3.1716 0.3165 99.8 2523.173 2522.171 -0.6 109590.7IPI:IPI00 1 3 2.70% 588 68231 6.8 U Tax_Id=10090 Gene_Symbol=Pes1 Pescadillo homolog 1, containing BRCT domain * FOXO_KO.1 5.8199 0.4554 100 1806.782 1804.779 -2.2 148157.4IPI:IPI001 1 1 2.70% 445 49990 7.2 U Tax_Id=10090 Gene_Symbol=Hgd Homogentisate 1,2-dioxygenase IPI:IPI00 1 1 2.70% 445 49960 7.2 U Tax_Id=10090 Gene_Symbol=Hgd homogentisate 1,2-dioxygenase

FOXO_KO.3 3.5514 0.2482 99.9 1525.757 1523.753 -2.1 337822.9IPI:IPI00 2 2 2.60% 1228 140622 6.5 U Tax_Id=10090 Gene_Symbol=Dhx38 Putative uncharacterized protein * FOXO_KO.1 4.778 0.4576 100 1624.704 1623.702 -1.2 183971.4

* FOXO_KO.2 4.0515 0.395 99.9 2101.926 2100.929 -3.1 236126.3IPI:IPI00 1 1 2.60% 1047 119825 5.7 U Tax_Id=10090 Gene_Symbol=Supt16h FACT complex subunit SPT16 * FOXO_KO.2 5.8055 0.4345 100 3165.44 3164.439 -0.8 96285.9IPI:IPI00 1 1 2.60% 643 68340 9.7 U Tax_Id=10090 Gene_Symbol=- 68 kDa protein IPI:IPI008 1 1 2.90% 581 62378 9.5 U Tax_Id=10090 Gene_Symbol=Slain2 Isoform 1 of SLAIN motif-containing protein 2 IPI:IPI007 1 1 2.80% 607 65272 9.8 U Tax_Id=10090 Gene_Symbol=Slain2 Isoform 2 of SLAIN motif-containing protein 2

FOXO_KO.2 5.6715 0.3448 100 2057.926 2055.918 0.7 80645.9IPI:IPI00 1 2 2.60% 615 67951 8.2 U Tax_Id=10090 Gene_Symbol=Acsf2 Acyl-CoA synthetase family member 2, mitochondrial IPI:IPI00 1 2 2.60% 615 67865 8.6 U Tax_Id=10090 Gene_Symbol=- 68 kDa protein

FOXO_KO.3 3.61 0.1893 99.6 1842.9 1841.896 0.6 124693.9IPI:IPI008 1 1 2.60% 588 67638 9.1 U Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 3 of Rho guanine nucleotide exchange factor 2 IPI:IPI008 1 1 2.60% 573 65836 9.1 U Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 2 of Rho guanine nucleotide exchange factor 2

FOXO_KO.2 4.1323 0.3809 100 1767.876 1767.876 0.1 163622.1IPI:IPI00 1 1 2.60% 505 56678 6.2 U Tax_Id=10090 Gene_Symbol=Pdia3 Protein disulfide-isomerase A3 * FOXO_KO.2 5.7825 0.4499 100 1609.757 1607.748 1.7 295389contamina 1 1 2.60% 456 49168 4.8 U no descriptioncontamina 1 1 2.50% 473 50915 5.5 U no description

FOXO_KO.1 4.3926 0.3543 100 1301.656 1301.658 -2 249696.4IPI:IPI00 1 1 2.60% 431 48841 8 U Tax_Id=10090 Gene_Symbol=Cyp2c50 Isoform 2 of Cytochrome P450 2C50 IPI:IPI00 1 1 4.70% 235 26813 6.9 U Tax_Id=10090 Gene_Symbol=LOC100044352 similar to cytochrome P450

FOXO_KO.1 3.4176 0.3861 100 1280.683 1280.684 -0.9 178111.9IPI:IPI00 1 1 2.60% 386 43596 5.5 U Tax_Id=10090 Gene_Symbol=Rbbp7 Retinoblastoma binding protein 7

FOXO_KO.1 2.4218 0.3388 99.8 1284.54 1284.541 -1.3 249218IPI:IPI00 1 1 2.50% 1090 119267 6.6 U Tax_Id=10090 Gene_Symbol=Fuk L-fucose kinase IPI:IPI00 1 1 3.70% 737 81012 7 U Tax_Id=10090 Gene_Symbol=Fuk MFLJ00241 protein IPI:IPI00 1 1 2.60% 1019 110873 6.3 U Tax_Id=10090 Gene_Symbol=Fuk Fucokinase, isoform CRA_a

FOXO_KO.3 4.2272 0.2508 99.8 3109.42 3107.412 0.2 91263.9IPI:IPI00 1 1 2.50% 1050 118231 6.6 U Tax_Id=10090 Gene_Symbol=Safb2 MKIAA0138 protein IPI:IPI00 1 1 2.80% 937 105104 5.4 U Tax_Id=10090 Gene_Symbol=Safb scaffold attachment factor B IPI:IPI00 1 1 2.60% 991 111839 6.4 U Tax_Id=10090 Gene_Symbol=Safb2 Scaffold attachment factor B2

FOXO_KO.1 3.862 0.2756 99.8 2775.312 2774.312 -1.2 90470IPI:IPI00 1 1 2.50% 727 79749 5.7 U Tax_Id=10090 Gene_Symbol=Ndufs1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

FOXO_KO.2 6.4697 0.5151 100 2165.958 2163.972 -9.3 137322.7IPI:IPI00 1 1 2.50% 612 70264 6.7 U Tax_Id=10090 Gene_Symbol=Crot Peroxisomal carnitine O-octanoyltransferase * FOXO_KO.3 3.0897 0.3204 99.9 1743.908 1743.905 1.6 90120.7IPI:IPI00 1 1 2.50% 608 68528 6.5 U Tax_Id=10090 Gene_Symbol=Rpn1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 * FOXO_KO.3 3.4616 0.4249 100 1647.861 1647.859 1 198109.6IPI:IPI00 1 2 2.50% 599 67314 8.3 U Tax_Id=10090 Gene_Symbol=Abce1 ATP-binding cassette sub-family E member 1 * FOXO_KO.4 4.6133 0.4141 100 1957.892 1957.897 -2.2 86699.2IPI:IPI00 2 2 2.50% 510 54599 7.6 U Tax_Id=10090 Gene_Symbol=Dld Dihydrolipoyl dehydrogenase IPI:IPI00 2 2 2.60% 509 54272 7.9 U Tax_Id=10090 Gene_Symbol=Dld Dihydrolipoyl dehydrogenase, mitochondrial

FOXO_KO.1 3.71 0.4235 100 1565.767 1565.769 -1.6 329312FOXO_KO.1 2.6035 0.3299 99.8 1565.768 1565.769 -0.7 316238.6

IPI:IPI00 1 1 2.50% 447 51462 6.4 U Tax_Id=10090 Gene_Symbol=Ppp2r2c Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform FOXO_KO.1 2.8864 0.2286 99.6 1332.606 1332.607 -0.5 183744.8

IPI:IPI00 1 2 2.50% 472 51066 8.4 U Tax_Id=10090 Gene_Symbol=Eif2s3x Eukaryotic translation initiation factor 2 subunit 3, X-linked IPI:IPI00 1 2 2.60% 468 50788 8.5 U Tax_Id=10090 Gene_Symbol=LOC100048746 similar to translation initiation factor eIF-2 gamma subunit IPI:IPI00 1 2 2.50% 480 52092 8.6 U Tax_Id=10090 Gene_Symbol=Gm2223 similar to translation initiation factor eIF-2 gamma subunit

FOXO_KO.3 2.696 0.2475 99.5 1315.685 1315.685 0.2 36447.1IPI:IPI00 1 1 2.50% 400 45940 5.8 U Tax_Id=10090 Gene_Symbol=Gm3555 similar to serine/threonine kinase 38-like

FOXO_KO.2 3.4678 0.3525 100 1136.584 1136.583 0.6 137864.8IPI:IPI001 1 1 2.50% 326 36069 9.2 U Tax_Id=10090 Gene_Symbol=Elavl1 ELAV-like protein 1 IPI:IPI00 1 1 2.50% 326 36169 9 U Tax_Id=10090 Gene_Symbol=Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1

FOXO_KO.1 2.3946 0.3148 99.8 998.4226 998.4247 -2.1 322960.1IPI:IPI00 1 1 2.40% 1034 117758 7 U Tax_Id=10090 Gene_Symbol=Ogdh Isoform 4 of 2-oxoglutarate dehydrogenase, mitochondrial IPI:IPI008 1 1 2.40% 1038 118179 6.9 U Tax_Id=10090 Gene_Symbol=Ogdh Isoform 3 of 2-oxoglutarate dehydrogenase, mitochondrial IPI:IPI00 1 1 2.50% 1019 116027 7 U Tax_Id=10090 Gene_Symbol=Ogdh Isoform 2 of 2-oxoglutarate dehydrogenase, mitochondrial IPI:IPI00 1 1 2.40% 1023 116449 6.8 U Tax_Id=10090 Gene_Symbol=Ogdh Isoform 1 of 2-oxoglutarate dehydrogenase, mitochondrial

FOXO_KO.2 4.4423 0.3261 99.9 2931.433 2930.43 -0.2 91451.1IPI:IPI00 1 1 2.40% 1025 113267 7.6 U Tax_Id=10090 Gene_Symbol=Gldc Glycine dehydrogenase [decarboxylating], mitochondrial IPI:IPI00 1 1 2.50% 1019 113188 8.2 U Tax_Id=10090 Gene_Symbol=Gldc Putative uncharacterized protein

FOXO_KO.3 4.1401 0.3976 99.9 2932.373 2931.372 -0.6 91802.7IPI:IPI00 1 1 2.40% 953 106248 5.8 U Tax_Id=10090 Gene_Symbol=Gaa Lysosomal alpha-glucosidase * FOXO_KO.3 3.6321 0.2938 99.9 2636.297 2634.283 2.6 116779.8IPI:IPI00 1 1 2.40% 901 102686 6.5 U Tax_Id=10090 Gene_Symbol=Exoc1 Exocyst complex component 1 IPI:IPI00 1 1 2.50% 894 101877 6.5 U Tax_Id=10090 Gene_Symbol=Exoc1 Exocyst complex component 1 IPI:IPI00 1 1 2.30% 945 107704 6.9 U Tax_Id=10090 Gene_Symbol=LOC100047515 similar to Exocyst complex component 1 IPI:IPI00 1 1 2.50% 879 100190 6.5 U Tax_Id=10090 Gene_Symbol=Exoc1 Exocyst complex component 1

FOXO_KO.5 6.6208 0.4337 100 2544.332 2543.327 0.5 146436IPI:IPI00 1 2 2.40% 797 92628 6 U Tax_Id=10090 Gene_Symbol=LOC100047696 similar to Eukaryotic translation initiation factor 3, subunit 8

FOXO_KO.1 6.9951 0.5233 100 2137.899 2136.899 -1.3 55269.9IPI:IPI00 1 1 2.40% 834 91831 9 U Tax_Id=10090 Gene_Symbol=Mogs Mannosyl-oligosaccharide glucosidase * FOXO_KO.1 4.8324 0.4765 100 2303.95 2303.952 -1.3 270469.5IPI:IPI00 2 3 2.40% 796 91713 5.4 U Tax_Id=10090 Gene_Symbol=Vps35 Vacuolar protein sorting-associated protein 35 * FOXO_KO.1 7.7338 0.5427 100 2245.099 2244.099 -1.3 57036.1* FOXO_KO.1 4.2358 0.2766 99.9 2245.1 2244.099 -1.1 159327.5IPI:IPI00 2 3 2.40% 702 80364 6.4 U Tax_Id=10090 Gene_Symbol=Gbe1 1,4-alpha-glucan-branching enzyme IPI:IPI00 2 3 15.20% 112 12023 4.9 U Tax_Id=10090 Gene_Symbol=Gbe1 Putative uncharacterized protein (Fragment)

FOXO_KO.1 6.3042 0.3461 100 1859.905 1857.898 0.4 99941.9FOXO_KO.1 3.4483 0.3873 99.9 1858.898 1857.898 -1.5 290469

IPI:IPI00 2 3 2.40% 715 80028 9 U Tax_Id=10090 Gene_Symbol=Yme1l1 ATP-dependent metalloprotease YME1L1 * FOXO_KO.3 6.7524 0.4505 100 1977.046 1975.038 0.4 123782.4* FOXO_KO.3 4.159 0.248 99.9 1976.043 1975.038 0.5 155931.7IPI:IPI00 1 2 2.40% 657 72538 6.2 U Tax_Id=10090 Gene_Symbol=Larp4b Isoform 2 of La-related protein 4B IPI:IPI00 1 2 2.40% 663 73563 7.8 U Tax_Id=10090 Gene_Symbol=Larp4b Isoform 3 of La-related protein 4B IPI:IPI00 1 2 2.20% 741 81627 7.5 U Tax_Id=10090 Gene_Symbol=Larp4b Isoform 1 of La-related protein 4B

FOXO_KO.4 4.7528 0.5583 100 1807.902 1806.901 -1 142700.3IPI:IPI00 1 2 2.40% 628 71303 6 U Tax_Id=10090 Gene_Symbol=Lrrfip1 Isoform 2 of Leucine-rich repeat flightless-interacting protein 1 IPI:IPI00 1 2 2.30% 663 75104 5.8 U Tax_Id=10090 Gene_Symbol=Lrrfip1 Lrrfip1 protein IPI:IPI00 1 2 3.50% 428 48918 5.6 U Tax_Id=10090 Gene_Symbol=Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 isoform 3

FOXO_KO.3 4.032 0.4134 100 1803.88 1803.879 0.2 146258.9IPI:IPI001 1 2 2.40% 505 57155 6.6 U Tax_Id=10090 Gene_Symbol=Cyp2d11 Cytochrome P450 2D11 IPI:IPI009 1 2 2.60% 453 51874 6.4 U Tax_Id=10090 Gene_Symbol=- Cyp2d12 protein IPI:IPI00 1 2 2.40% 504 56950 6.2 U Tax_Id=10090 Gene_Symbol=Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 IPI:IPI00 1 2 2.40% 504 57744 6.5 U Tax_Id=10090 Gene_Symbol=Cyp2d12 MCG10954, isoform CRA_a IPI:IPI00 1 2 2.40% 504 56988 6.3 U Tax_Id=10090 Gene_Symbol=Cyp2d11 cytochrome P450, family 2, subfamily d, polypeptide 11

FOXO_KO.3 4.1966 0.2101 99.9 1363.711 1363.71 0.3 149732.4IPI:IPI00 1 1 2.40% 500 56468 7 U Tax_Id=10090 Gene_Symbol=Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22

FOXO_KO.3 3.7547 0.4797 100 1350.677 1350.679 -1.5 215934.6IPI:IPI00 4 4 2.30% 2558 290581 5.9 U Tax_Id=10090 Gene_Symbol=Usp9x Ubiquitin carboxyl-terminal hydrolase

FOXO_KO.5 3.6111 0.3696 99.9 2810.489 2809.473 4.5 28570.9FOXO_KO.3 4.493 0.3793 100 1745.877 1744.875 -0.9 230162.2

* FOXO_KO.5 7.1503 0.5402 100 2421.164 2420.162 -0.5 55319.7* FOXO_KO.5 3.2618 0.2916 99.7 2421.17 2420.162 2.1 105321.7IPI:IPI00 1 1 2.30% 1132 126064 9.3 U Tax_Id=10090 Gene_Symbol=Rfc1 Rfc1 protein IPI:IPI008 1 1 2.30% 1131 125985 9.3 U Tax_Id=10090 Gene_Symbol=Rfc1 Isoform 1 of Replication factor C subunit 1 IPI:IPI003 1 1 2.30% 1130 125914 9.3 U Tax_Id=10090 Gene_Symbol=Rfc1 Isoform 2 of Replication factor C subunit 1

FOXO_KO.5 4.16 0.3199 99.9 2852.43 2850.419 1.6 31555.8IPI:IPI00 2 2 2.30% 1112 121646 8.9 U Tax_Id=10090 Gene_Symbol=Fam120a Constitutive coactivator of PPAR-gamma-like protein 1 * FOXO_KO.1 3.7188 0.4423 100 1413.706 1412.702 1.1 148554.6* FOXO_KO.1 3.6261 0.4079 100 1386.711 1386.711 -0.2 281101.4contamina 1 1 2.30% 1058 117790 5.9 U no description

FOXO_KO.1 4.1492 0.3216 99.9 2684.315 2683.317 -2 99887.1IPI:IPI00 1 2 2.30% 1033 115518 7.5 U Tax_Id=10090 Gene_Symbol=D030074E01Rik MKIAA1012 protein (Fragment) * FOXO_KO.4 5.8372 0.4009 100 2639.288 2638.28 1.5 75660.8IPI:IPI00 1 1 2.30% 844 94653 4.6 U Tax_Id=10090 Gene_Symbol=Saps3 Isoform 1 of Serine/threonine-protein phosphatase 6 regulatory subunit 3 * FOXO_KO.6 2.8888 0.2738 99.8 2085.203 2084.196 1.6 32762.4IPI:IPI00 1 1 2.30% 853 94430 6.7 U Tax_Id=10090 Gene_Symbol=Rbm10 Isoform 2 of RNA-binding protein 10

FOXO_KO.1 5.459 0.2541 100 2360.091 2359.09 -1 74024IPI:IPI00 1 1 2.30% 794 89273 5 U Tax_Id=10090 Gene_Symbol=Ctage5 CTAGE family, member 5 isoform 1 IPI:IPI00 1 1 2.30% 772 86730 5.3 U Tax_Id=10090 Gene_Symbol=Ctage5 CTAGE family, member 5 isoform 2 IPI:IPI00 1 1 2.40% 761 85622 5.1 U Tax_Id=10090 Gene_Symbol=Ctage5 CTAGE family, member 5 isoform 3

FOXO_KO.3 3.8233 0.4439 100 2216.171 2215.17 -1.2 223390.3IPI:IPI00 1 1 2.30% 693 76922 6.8 U Tax_Id=10090 Gene_Symbol=Ppfibp1 Isoform 2 of Liprin-beta-1 IPI:IPI00 1 1 6.10% 262 29855 6.4 U Tax_Id=10090 Gene_Symbol=Ppfibp1 Ppfibp1 protein

FOXO_KO.3 4.5798 0.4805 100 1751.896 1750.893 -0.5 136623.9IPI:IPI00 1 5 2.30% 608 68693 6.1 U Tax_Id=10090 Gene_Symbol=Alb Serum albumin

FOXO_KO.9 4.7074 0.3699 100 1750.661 1749.663 -3 176832.2IPI:IPI003 1 2 2.30% 598 67956 6.2 U Tax_Id=10090 Gene_Symbol=Fbxw8 Isoform 1 of F-box/WD repeat-containing protein 8 IPI:IPI003 1 2 3.10% 456 51673 5.6 U Tax_Id=10090 Gene_Symbol=Fbxw8 Isoform 2 of F-box/WD repeat-containing protein 8

FOXO_KO.3 3.6717 0.4101 100 1695.814 1693.807 0.3 240352.2IPI:IPI00 1 1 2.30% 432 48958 8 U Tax_Id=10090 Gene_Symbol=LOC100048323 similar to RIKEN cDNA C730004C24 gene isoform 3 IPI:IPI00 1 1 2.30% 432 48903 7.8 U Tax_Id=10090 Gene_Symbol=Cyp2c69 similar to RIKEN cDNA C730004C24 gene isoform 3

FOXO_KO.2 3.2254 0.3837 100 1135.638 1135.636 1.7 236375.4IPI:IPI00 4 4 2.20% 2158 229200 9.4 U Tax_Id=10090 Gene_Symbol=Bat2 Large proline-rich protein BAT2 * FOXO_KO.2 4.1521 0.4059 99.9 3540.498 3539.499 -1.3 82695.4* FOXO_KO.2 5.2885 0.2667 99.9 3541.503 3539.499 -0.7 170184* FOXO_KO.1 5.1564 0.3359 100 2008.888 2007.887 -1 106997.4* FOXO_KO.1 3.2875 0.3536 99.9 2007.886 2007.887 -0.4 189946.4IPI:IPI00 1 1 2.20% 1252 135175 8.4 U Tax_Id=10090 Gene_Symbol=2310057J16Rik Isoform 1 of Calmodulin-regulated spectrin-associated protein 3 IPI:IPI00 1 1 2.20% 1253 135274 8.4 U Tax_Id=10090 Gene_Symbol=2310057J16Rik Nezha isoform 1 IPI:IPI00 1 1 2.40% 1182 127774 8.2 U Tax_Id=10090 Gene_Symbol=2310057J16Rik Isoform 2 of Calmodulin-regulated spectrin-associated protein 3

FOXO_KO.4 4.0423 0.4171 99.9 2972.496 2970.48 3.2 49034.6IPI:IPI00 3 4 2.20% 1029 114996 5.5 U Tax_Id=10090 Gene_Symbol=Ppp1r12a Isoform 1 of Protein phosphatase 1 regulatory subunit 12A

IPI:IPI00 3 4 2.30% 1004 111809 5.6 U Tax_Id=10090 Gene_Symbol=Ppp1r12a Isoform 2 of Protein phosphatase 1 regulatory subunit 12A FOXO_KO.4 7.0416 0.5878 100 2454.211 2453.208 -0.2 29513.6FOXO_KO.4 4.9902 0.2448 99.9 2453.211 2453.208 1.1 107106.2FOXO_KO.4 3.0283 0.3446 99.9 2582.305 2581.303 -0.6 70878.3

IPI:IPI00 1 2 2.20% 869 99725 6.7 U Tax_Id=10090 Gene_Symbol=Znfx1 Zinc finger, NFX1-type containing 1 IPI:IPI00 1 2 2.30% 840 96385 6.7 U Tax_Id=10090 Gene_Symbol=Znfx1 Zinc finger, NFX1-type containing 1

FOXO_KO.2 6.4705 0.6017 100 2160.012 2159.014 -2.3 62344.5IPI:IPI00 1 1 2.20% 899 99103 7.3 U Tax_Id=10090 Gene_Symbol=Aco1 Cytoplasmic aconitase IPI:IPI00 1 1 2.20% 889 98126 7.5 U Tax_Id=10090 Gene_Symbol=Aco1 aconitase 1

FOXO_KO.3 5.175 0.3296 100 2328.071 2326.072 -3.2 233638.6IPI:IPI00 2 2 2.20% 802 92190 8 U Tax_Id=10090 Gene_Symbol=Cdc5l Cell division cycle 5-related protein IPI:IPI00 2 2 2.30% 789 90970 7.8 U Tax_Id=10090 Gene_Symbol=Gm9030 similar to Cell division cycle 5-like IPI:IPI00 2 2 2.30% 789 90943 7.6 U Tax_Id=10090 Gene_Symbol=Gm9029 similar to Cell division cycle 5-like

FOXO_KO.2 3.1876 0.3108 99.9 1517.747 1517.748 -1 214348.7FOXO_KO.2 4.5592 0.3995 100 2175.065 2174.061 0.4 78050.1

IPI:IPI00 1 1 2.20% 779 87366 8.4 U Tax_Id=10090 Gene_Symbol=Nphp3;Acad11 Acyl-CoA dehydrogenase family member 11 IPI:IPI00 1 1 2.60% 661 74089 8.1 U Tax_Id=10090 Gene_Symbol=Nphp3 74 kDa protein

FOXO_KO.1 4.5953 0.3984 100 1962.856 1961.855 -1.1 157906.2IPI:IPI00 1 1 2.20% 757 83900 6.6 U Tax_Id=10090 Gene_Symbol=Immt Isoform 1 of Mitochondrial inner membrane protein IPI:IPI00 1 1 2.40% 709 78727 7.3 U Tax_Id=10090 Gene_Symbol=Immt Isoform 3 of Mitochondrial inner membrane protein IPI:IPI00 1 1 2.10% 791 87823 7.3 U Tax_Id=10090 Gene_Symbol=Immt Isoform 5 of Mitochondrial inner membrane protein IPI:IPI00 1 1 2.30% 741 82416 6.7 U Tax_Id=10090 Gene_Symbol=Immt Putative uncharacterized protein IPI:IPI00 1 1 2.30% 746 82929 6.6 U Tax_Id=10090 Gene_Symbol=Immt Isoform 2 of Mitochondrial inner membrane protein

FOXO_KO.2 6.7363 0.2781 100 2085.018 2084.018 -1.6 112734.3IPI:IPI002 1 2 2.20% 769 82736 5.5 U Tax_Id=10090 Gene_Symbol=Cast Isoform 2 of Calpastatin IPI:IPI007 1 2 2.30% 754 81441 5.4 U Tax_Id=10090 Gene_Symbol=Cast Putative uncharacterized protein IPI:IPI004 1 2 2.20% 788 84922 5.5 U Tax_Id=10090 Gene_Symbol=Cast Isoform 1 of Calpastatin IPI:IPI002 1 2 2.20% 773 83626 5.4 U Tax_Id=10090 Gene_Symbol=Cast Isoform 6 of Calpastatin IPI:IPI002 1 2 3.90% 431 47366 4.9 U Tax_Id=10090 Gene_Symbol=Cast Isoform 5 of Calpastatin IPI:IPI002 1 2 3.80% 446 49125 4.9 U Tax_Id=10090 Gene_Symbol=Cast Isoform 4 of Calpastatin IPI:IPI002 1 2 2.30% 740 79695 5.5 U Tax_Id=10090 Gene_Symbol=Cast Isoform 3 of Calpastatin

FOXO_KO.3 5.4353 0.4159 100 1868.896 1867.892 0.2 96845.8IPI:IPI00 1 1 2.20% 734 79513 8 U Tax_Id=10090 Gene_Symbol=Trim56 Tripartite motif-containing protein 56 IPI:IPI00 1 1 2.20% 734 79529 7.9 U Tax_Id=10090 Gene_Symbol=Trim56 tripartite motif-containing 56

FOXO_KO.1 3.831 0.3488 100 1674.79 1674.793 -1.6 151407IPI:IPI00 1 1 2.20% 539 58911 8.1 U Tax_Id=10090 Gene_Symbol=Krt73 Keratin, type II cytoskeletal 73 IPI:IPI00 1 1 2.30% 524 57383 7 U Tax_Id=10090 Gene_Symbol=Krt71 Keratin, type II cytoskeletal 71 IPI:IPI004 1 1 2.40% 495 54747 5.7 U Tax_Id=10090 Gene_Symbol=Krt74 Keratin, type II cytoskeletal 74

FOXO_KO.1 4.5895 0.3602 100 1475.782 1475.785 -2.1 241573.9IPI:IPI00 1 1 2.20% 509 55277 6.1 U Tax_Id=10090 Gene_Symbol=- ATP synthase subunit alpha

FOXO_KO.1 3.2404 0.3103 99.9 1287.693 1287.694 -0.8 276195.9IPI:IPI00 2 3 2.10% 1909 218866 7.5 U Tax_Id=10090 Gene_Symbol=Znfx1 NFX1-type zinc finger-containing protein 1 IPI:IPI00 2 3 2.10% 1909 218826 7.5 U Tax_Id=10090 Gene_Symbol=Znfx1 zinc finger, NFX1-type containing 1

FOXO_KO.2 6.4705 0.6017 100 2160.012 2159.014 -2.3 62344.5FOXO_KO.3 6.1447 0.5291 100 2501.125 2499.113 1.8 36277

IPI:IPI00 2 2 2.10% 1262 144256 6.6 U Tax_Id=10090 Gene_Symbol=Iars Isoleucyl-tRNA synthetase, cytoplasmic IPI:IPI00 2 2 2.10% 1262 144270 6.6 U Tax_Id=10090 Gene_Symbol=Iars isoleucine tRNA synthetase

FOXO_KO.1 2.7425 0.2608 99.8 1281.597 1281.596 0.7 150440.2

FOXO_KO.2 5.2407 0.3983 100 1876.983 1875.981 -0.8 184949.7IPI:IPI00 2 4 2.10% 1178 129685 6.7 U Tax_Id=10090 Gene_Symbol=Pcx Pyruvate carboxylase, mitochondrial IPI:IPI00 2 4 2.10% 1179 129832 6.7 U Tax_Id=10090 Gene_Symbol=Pcx pyruvate carboxylase isoform 1

FOXO_KO.1 5.3793 0.3765 100 1769.824 1767.818 -0.8 123282.9FOXO_KO.2 4.266 0.4174 100 1363.673 1363.674 -0.6 196023

IPI:IPI00 1 1 2.10% 853 92851 6.5 U Tax_Id=10090 Gene_Symbol=Kdm1a Lysine-specific histone demethylase 1 IPI:IPI00 1 1 2.30% 780 86540 6.2 U Tax_Id=10090 Gene_Symbol=LOC100046934 similar to amine oxidase (flavin containing) domain 2 IPI:IPI00 1 1 8.50% 211 24482 5.3 U Tax_Id=10090 Gene_Symbol=Kdm1a Amine oxidase (Flavin containing) domain 2 IPI:IPI00 1 1 2.10% 873 94659 6.2 U Tax_Id=10090 Gene_Symbol=Kdm1a Amine oxidase (Flavin containing) domain 2

FOXO_KO.2 4.835 0.4881 100 2205.984 2204.963 8 52911.3IPI:IPI00 1 1 2.10% 793 90583 7 U Tax_Id=10090 Gene_Symbol=Dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 10 IPI:IPI00 1 1 2.10% 793 90605 7.1 U Tax_Id=10090 Gene_Symbol=Dnajc10 DnaJ homolog subfamily C member 10 IPI:IPI00 1 1 9.30% 182 21133 6.5 U Tax_Id=10090 Gene_Symbol=Dnajc10 Putative uncharacterized protein (Fragment)

FOXO_KO.3 6.2259 0.5012 100 2075.966 2073.965 -2.8 154758.5IPI:IPI00 1 2 2.10% 798 88791 6.4 U Tax_Id=10090 Gene_Symbol=Csde1 Cold shock domain-containing protein E1 IPI:IPI00 1 2 2.20% 767 85653 6.3 U Tax_Id=10090 Gene_Symbol=Csde1 cold shock domain containing E1, RNA binding isoform 2 IPI:IPI00 1 2 2.10% 822 92144 6.2 U Tax_Id=10090 Gene_Symbol=Csde1 MKIAA0885 protein (Fragment)

FOXO_KO.1 5.9519 0.3834 100 1899.856 1897.848 0.5 106534IPI:IPI00 1 1 2.10% 760 85911 9.2 U Tax_Id=10090 Gene_Symbol=Ddx27 Isoform 1 of Probable ATP-dependent RNA helicase DDX27 IPI:IPI00 1 1 2.10% 760 85939 9.2 U Tax_Id=10090 Gene_Symbol=Ddx27 MCG14602, isoform CRA_c

FOXO_KO.1 4.5974 0.4431 100 1692.719 1691.718 -1.4 162637.9IPI:IPI001 2 2 2.10% 780 85464 7.9 U Tax_Id=10090 Gene_Symbol=Aco2 Aconitate hydratase, mitochondrial * FOXO_KO.1 5.9604 0.4875 100 1869.919 1868.914 0.9 144155.7* FOXO_KO.1 4.4349 0.4029 100 1868.911 1868.914 -1.6 258439.7IPI:IPI00 1 1 2.10% 681 76893 7.3 U Tax_Id=10090 Gene_Symbol=Acox2 Peroxisomal acyl-coenzyme A oxidase 2 IPI:IPI00 1 1 2.10% 681 76863 7.5 U Tax_Id=10090 Gene_Symbol=Acox2 acyl-Coenzyme A oxidase 2

FOXO_KO.2 3.8021 0.2416 99.9 1603.759 1602.755 0.5 330473.6IPI:IPI001 1 1 2.10% 528 59697 9.1 U Tax_Id=10090 Gene_Symbol=Psip1 Isoform 1 of PC4 and SFRS1-interacting protein IPI:IPI00 1 1 12.20% 90 10353 9.2 U Tax_Id=10090 Gene_Symbol=Psip1 PC4 and SFRS1 interacting protein 1 IPI:IPI00 1 1 3.40% 327 36968 9.2 U Tax_Id=10090 Gene_Symbol=Psip1 PC4 and SFRS1 interacting protein 1 IPI:IPI006 1 1 3.30% 331 37426 9.2 U Tax_Id=10090 Gene_Symbol=Psip1 Isoform 2 of PC4 and SFRS1-interacting protein

FOXO_KO.1 3.0399 0.2598 99.8 1369.662 1369.663 -1.3 131844.4IPI:IPI00 1 1 2.10% 424 44816 8.5 U Tax_Id=10090 Gene_Symbol=Acat1 Acetyl-CoA acetyltransferase, mitochondrial * FOXO_KO.1 2.9666 0.3052 99.9 1024.495 1024.495 0 371939.7IPI:IPI004 2 2 2.00% 1600 176076 5.4 U Tax_Id=10090 Gene_Symbol=Eif4g1 Isoform 1 of Eukaryotic translation initiation factor 4 gamma 1 IPI:IPI00 2 2 2.00% 1594 175458 5.4 U Tax_Id=10090 Gene_Symbol=Eif4g1 eukaryotic translation initiation factor 4, gamma 1 isoform b IPI:IPI00 2 2 2.10% 1553 171283 5.3 U Tax_Id=10090 Gene_Symbol=Eif4g1 Eif4g1 protein IPI:IPI00 2 2 2.00% 1586 174579 5.4 U Tax_Id=10090 Gene_Symbol=Eif4g1 Isoform 2 of Eukaryotic translation initiation factor 4 gamma 1

FOXO_KO.2 4.3719 0.3996 100 1725.833 1725.833 0 181391.8FOXO_KO.1 6.0786 0.564 100 1792.872 1792.871 0.3 89747.9

IPI:IPI00 2 2 2.00% 1223 136486 8.4 U Tax_Id=10090 Gene_Symbol=Dhx30 Isoform 3 of Putative ATP-dependent RNA helicase DHX30 IPI:IPI00 2 2 2.00% 1186 133028 8.6 U Tax_Id=10090 Gene_Symbol=Dhx30 133 kDa protein IPI:IPI00 2 2 2.00% 1194 134059 8.8 U Tax_Id=10090 Gene_Symbol=Dhx30 Isoform 2 of Putative ATP-dependent RNA helicase DHX30 IPI:IPI00 2 2 2.00% 1217 136668 8.7 U Tax_Id=10090 Gene_Symbol=Dhx30 Isoform 1 of Putative ATP-dependent RNA helicase DHX30

FOXO_KO.2 4.3458 0.4406 100 2588.262 2588.255 2.7 18374FOXO_KO.2 4.3103 0.3594 99.9 2589.258 2588.255 -0.1 270326.5

IPI:IPI00 1 1 2.00% 1051 121627 8.2 U Tax_Id=10090 Gene_Symbol=Smarca5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 * FOXO_KO.2 3.4538 0.3415 99.9 2563.084 2561.077 -0.1 152788.9

IPI:IPI00 1 1 2.00% 1045 119496 7.9 U Tax_Id=10090 Gene_Symbol=Znfx1 Zinc finger, NFX1-type containing 1 FOXO_KO.3 6.1447 0.5291 100 2501.125 2499.113 1.8 36277

IPI:IPI00 1 1 2.00% 985 113248 8.4 U Tax_Id=10090 Gene_Symbol=2610101N10Rik Isoform 3 of U2-associated protein SR140 IPI:IPI00 1 1 1.90% 1029 118246 8.5 U Tax_Id=10090 Gene_Symbol=2610101N10Rik Isoform 1 of U2-associated protein SR140 IPI:IPI00 1 1 1.90% 1028 118189 8.5 U Tax_Id=10090 Gene_Symbol=2610101N10Rik Isoform 2 of U2-associated protein SR140

FOXO_KO.4 2.5914 0.2837 99.6 2131.979 2131.982 -1.6 59128IPI:IPI00 1 3 2.00% 942 105775 6.6 U Tax_Id=10090 Gene_Symbol=Wdr3 WD repeat-containing protein 3 * FOXO_KO.3 6.5475 0.5145 100 2304.056 2302.04 4 79458.6IPI:IPI00 1 1 2.00% 864 101284 8.4 U Tax_Id=10090 Gene_Symbol=Naa16 NMDA receptor-regulated 1-like protein * FOXO_KO.3 3.5995 0.3255 99.9 2079.987 2079.987 0.1 123648.7IPI:IPI00 1 1 2.00% 906 100106 6.2 U Tax_Id=10090 Gene_Symbol=Ctnna1 Catenin alpha-1 * FOXO_KO.2 5.2101 0.5212 100 2239.864 2238.86 0.5 40942.5IPI:IPI00 1 1 2.00% 710 77891 7.1 U Tax_Id=10090 Gene_Symbol=Lonp2 Isoform 3 of Peroxisomal Lon protease homolog 2

FOXO_KO.2 3.5783 0.2471 99.8 1742.83 1742.834 -2.3 133937.3IPI:IPI00 1 1 2.00% 589 65670 7.1 U Tax_Id=10090 Gene_Symbol=Farsb Phenylalanyl-tRNA synthetase beta chain IPI:IPI00 1 1 2.00% 589 65816 7.4 U Tax_Id=10090 Gene_Symbol=Farsb Putative uncharacterized protein

FOXO_KO.1 4.008 0.2348 99.9 1542.742 1542.743 -0.7 266543.3IPI:IPI001 1 2 2.00% 562 60322 8.3 U Tax_Id=10090 Gene_Symbol=Krt6b Keratin, type II cytoskeletal 6B IPI:IPI00 1 2 4.90% 224 24093 8.6 U Tax_Id=10090 Gene_Symbol=- 24 kDa protein IPI:IPI00 1 2 2.00% 554 59526 8.2 U Tax_Id=10090 Gene_Symbol=Krt6b keratin complex 2, basic, gene 6b IPI:IPI00 1 2 2.40% 463 50387 5.4 U Tax_Id=10090 Gene_Symbol=Krt6a 50 kDa protein IPI:IPI00 1 2 2.00% 552 60228 7.3 U Tax_Id=10090 Gene_Symbol=Gm5414 Type II keratin Kb14 IPI:IPI00 1 2 2.00% 553 59335 7.9 U Tax_Id=10090 Gene_Symbol=Krt6a Keratin, type II cytoskeletal 6A

FOXO_KO_w 3.5977 0.3299 100 1315.697 1315.696 0.6 55449.6IPI:IPI00 1 2 2.00% 446 48922 5.1 U Tax_Id=10090 Gene_Symbol=Krt25 Keratin, type I cytoskeletal 25 IPI:IPI00 1 2 2.00% 452 49138 4.9 U Tax_Id=10090 Gene_Symbol=Krt15 Keratin, type I cytoskeletal 15 IPI:IPI00 1 2 2.00% 456 49494 4.9 U Tax_Id=10090 Gene_Symbol=Krt15 keratin 15 IPI:IPI00 1 2 2.00% 448 49105 5 U Tax_Id=10090 Gene_Symbol=Krt27 Keratin, type I cytoskeletal 27

FOXO_KO.1 3.3486 0.3289 100 1090.532 1090.531 0.6 431043.9IPI:IPI00 3 4 1.90% 3053 341092 6.2 U Tax_Id=10090 Gene_Symbol=Ranbp2 E3 SUMO-protein ligase RanBP2 * FOXO_KO.4 4.1714 0.3932 100 1681.871 1681.868 1.7 178069.1* FOXO_KO.1 6.4455 0.4332 100 2781.271 2780.268 0 73086.6* FOXO_KO.4 6.377 0.495 100 2438.104 2436.095 1.3 74412IPI:IPI00 2 2 1.90% 2464 270252 4.8 U Tax_Id=10090 Gene_Symbol=Mtap1b microtubule-associated protein 1B

FOXO_KO.3 3.8666 0.3556 100 1977.924 1977.922 1 83840.4* FOXO_KO.1 5.2294 0.4269 100 3389.641 3387.634 0.3 55023.8IPI:IPI00 1 1 1.90% 1072 121152 8.8 U Tax_Id=10090 Gene_Symbol=Larp1 Isoform 1 of La-related protein 1 * FOXO_KO.2 5.6666 0.4638 100 2363.106 2362.108 -2.3 136000.1IPI:IPI00 1 1 1.90% 1058 120179 5.1 U Tax_Id=10090 Gene_Symbol=Gemin4 gemin 4 * FOXO_KO.6 5.9704 0.5333 100 2246.168 2245.163 0.7 43990.7IPI:IPI00 1 2 1.90% 948 105694 7.8 U Tax_Id=10090 Gene_Symbol=Zc3h18 Isoform 1 of Zinc finger CCCH domain-containing protein 18 IPI:IPI00 1 2 1.90% 972 108231 8 U Tax_Id=10090 Gene_Symbol=Zc3h18 conserved nuclear protein Nhn1 isoform a

FOXO_KO.2 4.9489 0.4051 100 2253.991 2252.987 0.2 70045.8IPI:IPI00 1 1 1.90% 782 88383 5.1 U Tax_Id=10090 Gene_Symbol=Cpsf2 Cleavage and polyadenylation specificity factor subunit 2 * FOXO_KO.2 3.056 0.3702 99.9 1764.812 1764.808 2.7 64994.8IPI:IPI00 1 1 1.90% 634 74113 9.5 U Tax_Id=10090 Gene_Symbol=Gtpbp4 Nucleolar GTP-binding protein 1 * FOXO_KO.1 3.7777 0.1772 99.5 1544.818 1544.817 0.7 237449.6IPI:IPI00 1 2 1.90% 631 69063 5.8 U Tax_Id=10090 Gene_Symbol=Rpn2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

IPI:IPI00 1 2 1.80% 675 73584 6 U Tax_Id=10090 Gene_Symbol=Rpn2 Putative uncharacterized protein IPI:IPI00 1 2 2.00% 615 67502 6.2 U Tax_Id=10090 Gene_Symbol=Rpn2 Ribophorin II

FOXO_KO.4 4.634 0.3661 100 1400.749 1399.743 1.8 139357.3IPI:IPI00 2 3 1.90% 531 57552 7.7 U Tax_Id=10090 Gene_Symbol=Krt79 Keratin, type II cytoskeletal 79

FOXO_KO_w 2.9416 0.225 99.8 1308.655 1308.654 0.5 40177.7FOXO_KO.4 2.8604 0.355 99.9 1308.656 1308.654 1.5 125715

IPI:IPI00 1 3 1.90% 464 50834 8.2 U Tax_Id=10090 Gene_Symbol=Ndufv1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial IPI:IPI00 1 3 2.00% 455 49913 8.1 U Tax_Id=10090 Gene_Symbol=Ndufv1 50 kDa protein IPI:IPI00 1 3 2.30% 385 41834 7 U Tax_Id=10090 Gene_Symbol=Ndufv1 42 kDa protein

FOXO_KO_w 2.9586 0.4135 99.9 1198.595 1198.596 -1.2 81050.5IPI:IPI00 2 3 1.80% 2646 297588 6.8 U Tax_Id=10090 Gene_Symbol=Setx Isoform 1 of Probable helicase senataxin * FOXO_KO.4 3.7662 0.2918 99.9 2293.086 2292.085 -1.3 107613.4

FOXO_KO.1 4.9064 0.376 99.9 3265.549 3264.55 -1.6 59811IPI:IPI00 1 1 1.80% 1207 136705 9.1 U Tax_Id=10090 Gene_Symbol=Polrmt DNA-directed RNA polymerase, mitochondrial IPI:IPI00 1 1 1.90% 1133 128335 9 U Tax_Id=10090 Gene_Symbol=Polrmt DNA-directed RNA polymerase IPI:IPI00 1 1 2.40% 903 102203 9.1 U Tax_Id=10090 Gene_Symbol=Polrmt 102 kDa protein IPI:IPI00 1 1 5.60% 393 44851 8.3 U Tax_Id=10090 Gene_Symbol=Polrmt Protein

FOXO_KO.4 4.8797 0.2764 100 2406.145 2406.149 -1.8 23416.3IPI:IPI008 1 1 1.80% 1239 136350 4.4 U Tax_Id=10090 Gene_Symbol=Mia3 Isoform 2 of Melanoma inhibitory activity protein 3 * FOXO_KO.5 4.5969 0.3525 100 2580.276 2580.272 1.6 16333.2IPI:IPI00 2 2 1.80% 1107 126818 9.1 U Tax_Id=10090 Gene_Symbol=Myo1e myosin IE * FOXO_KO.6 4.9379 0.4721 100 2369.219 2368.218 -0.8 49803* FOXO_KO.6 5.9077 0.4022 100 2370.225 2368.218 0.4 79071.7IPI:IPI001 1 1 1.80% 1065 119519 7.1 U Tax_Id=10090 Gene_Symbol=Nol6 Isoform 2 of Nucleolar protein 6 IPI:IPI00 1 1 1.60% 1152 129228 6.8 U Tax_Id=10090 Gene_Symbol=Nol6 Isoform 1 of Nucleolar protein 6

FOXO_KO.2 3.7148 0.2763 99.9 2169.969 2168.973 -3.2 64153.1IPI:IPI00 1 2 1.80% 1013 111691 5.4 U Tax_Id=10090 Gene_Symbol=Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 IPI:IPI00 1 2 1.90% 947 103586 5.4 U Tax_Id=10090 Gene_Symbol=Atp1a2 104 kDa protein IPI:IPI00 1 2 1.70% 1053 115969 5.6 U Tax_Id=10090 Gene_Symbol=Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide, isoform CRA_c IPI:IPI00 1 2 1.80% 1020 112217 5.5 U Tax_Id=10090 Gene_Symbol=Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2

FOXO_KO.2 5.9796 0.4814 100 1830.931 1829.924 1.9 200967.5IPI:IPI00 1 1 1.80% 971 109361 5 U Tax_Id=10090 Gene_Symbol=Eftud2 116 kDa U5 small nuclear ribonucleoprotein component IPI:IPI00 1 1 1.70% 972 109492 5 U Tax_Id=10090 Gene_Symbol=Eftud2 elongation factor Tu GTP binding domain containing 2 isoform b

FOXO_KO.4 4.474 0.5101 100 1986 1985.993 3.7 68451.1IPI:IPI00 1 1 1.80% 926 102975 6.9 U Tax_Id=10090 Gene_Symbol=Aass Alpha-aminoadipic semialdehyde synthase, mitochondrial * FOXO_KO.1 3.8955 0.4463 100 2087.986 2087.992 -3 171865IPI:IPI003 1 1 1.80% 838 94382 5.7 U Tax_Id=10090 Gene_Symbol=Hspa4l Isoform 1 of Heat shock 70 kDa protein 4L IPI:IPI00 1 1 2.60% 571 63555 6.3 U Tax_Id=10090 Gene_Symbol=Hspa4l 64 kDa protein IPI:IPI003 1 1 1.80% 817 92252 5.9 U Tax_Id=10090 Gene_Symbol=Hspa4l Isoform 2 of Heat shock 70 kDa protein 4L

FOXO_KO.1 4.9872 0.5837 100 1706.719 1706.721 -1.6 191585.5IPI:IPI001 1 1 1.80% 784 91514 5.4 U Tax_Id=10090 Gene_Symbol=Cdk11b Isoform 1 of Cell division protein kinase 11 IPI:IPI006 1 1 1.90% 750 87320 5.3 U Tax_Id=10090 Gene_Symbol=Cdk11b Cell division cycle 2-like 1

FOXO_KO.3 2.7665 0.2617 99.6 1606.763 1605.76 -0.4 170413.1IPI:IPI00 1 1 1.80% 760 87437 6.4 U Tax_Id=10090 Gene_Symbol=Dpp4 Dipeptidyl peptidase 4 IPI:IPI00 1 1 1.90% 729 83802 6.4 U Tax_Id=10090 Gene_Symbol=Dpp4 dipeptidylpeptidase 4 isoform 2

FOXO_KO.2 4.658 0.4164 100 1544.803 1543.796 1.9 271250.4IPI:IPI00 1 1 1.80% 728 83330 9.2 U Tax_Id=10090 Gene_Symbol=Gnl2 Nucleolar GTP-binding protein 2 IPI:IPI00 1 1 1.80% 728 83346 9.2 U Tax_Id=10090 Gene_Symbol=Gnl2 guanine nucleotide binding protein-like 2

FOXO_KO.2 4.284 0.3928 100 1609.735 1609.738 -2 203692.6IPI:IPI00 1 1 1.80% 614 69320 8.9 U Tax_Id=10090 Gene_Symbol=Ddx5 Probable ATP-dependent RNA helicase DDX5 * FOXO_KO.1 3.6677 0.3621 100 1295.647 1295.648 -0.9 433456.9IPI:IPI00 1 1 1.70% 1333 149583 6 U Tax_Id=10090 Gene_Symbol=Ikbkap Elongator complex protein 1 * FOXO_KO.5 7.8896 0.5212 100 2398.284 2397.276 2 118209.4IPI:IPI00 1 1 1.70% 1233 141457 5.1 U Tax_Id=10090 Gene_Symbol=Slk Isoform 1 of STE20-like serine/threonine-protein kinase IPI:IPI007 1 1 1.70% 1202 137713 5.1 U Tax_Id=10090 Gene_Symbol=Slk Isoform 2 of STE20-like serine/threonine-protein kinase

FOXO_KO.5 5.7149 0.557 100 2336.111 2336.108 1 44190.1IPI:IPI00 1 1 1.70% 1263 140215 7.8 U Tax_Id=10090 Gene_Symbol=Vars Valyl-tRNA synthetase * FOXO_KO.2 5.6093 0.4808 100 2396.229 2396.23 -0.5 195942IPI:IPI00 1 1 1.70% 1101 120795 7.4 U Tax_Id=10090 Gene_Symbol=Acly Putative uncharacterized protein IPI:IPI00 1 1 1.70% 1091 119728 7.4 U Tax_Id=10090 Gene_Symbol=Acly ATP-citrate synthase

FOXO_KO.5 6.7964 0.5256 100 2156.088 2155.081 2 115468.5IPI:IPI00 1 2 1.70% 1132 117966 7.7 U Tax_Id=10090 Gene_Symbol=Ubap2 Ubiquitin-associated protein 2 * FOXO_KO.2 7.0994 0.5075 100 2299.988 2298.989 -1.7 58761.5IPI:IPI001 1 1 1.70% 1013 113100 9 U Tax_Id=10090 Gene_Symbol=Parp1 Isoform 1 of Poly [ADP-ribose] polymerase 1 IPI:IPI007 1 1 3.50% 492 55237 8 U Tax_Id=10090 Gene_Symbol=Parp1 Isoform 2 of Poly [ADP-ribose] polymerase 1 IPI:IPI00 1 1 1.70% 1014 112707 9 U Tax_Id=10090 Gene_Symbol=Parp1 Putative uncharacterized protein

FOXO_KO.1 2.7885 0.3787 99.9 1825.809 1825.809 0 127553IPI:IPI00 1 1 1.70% 953 108481 7.7 U Tax_Id=10090 Gene_Symbol=Prpf40a Isoform 1 of Pre-mRNA-processing factor 40 homolog A IPI:IPI003 1 1 1.80% 911 103963 7.6 U Tax_Id=10090 Gene_Symbol=Prpf40a Isoform 2 of Pre-mRNA-processing factor 40 homolog A

FOXO_KO.2 3.9042 0.322 99.9 1909.956 1909.954 0.8 176270.3IPI:IPI003 1 3 1.70% 894 103653 5.5 U Tax_Id=10090 Gene_Symbol=Actn2 Alpha-actinin-2 IPI:IPI00 1 3 1.70% 894 103834 5.5 U Tax_Id=10090 Gene_Symbol=Actn2 actinin alpha 2

FOXO_KO_w 6.4706 0.575 100 1754.827 1753.825 -0.7 24820.2IPI:IPI00 1 1 1.70% 768 88948 8.4 U Tax_Id=10090 Gene_Symbol=Cul3 Cullin-3 * FOXO_KO.2 4.1029 0.3674 100 1474.763 1474.764 -0.5 204720.6IPI:IPI00 1 4 1.70% 641 70637 6.2 U Tax_Id=10090 Gene_Symbol=Hspa1l Heat shock 70 kDa protein 1-like contamina 1 4 1.70% 663 73081 4.9 U owl|P36604| 78 KD GLUCOSE REGULATED PROTEIN HOMOLOG PRECURSOR (GRP 78) (IMMUNOGLOBULIN... contamina 1 4 1.70% 666 73235 5.2 U owl|P49118| 78 KD GLUCOSE REGULATED PROTEIN HOMOLOG PRECURSOR (GRP 78) (IMMUNOGLOBULIN... IPI:IPI00 1 4 9.90% 111 12137 9.1 U Tax_Id=10090 Gene_Symbol=Hspa1a Spermatid-specific heat shock protein 70 (Fragment)

FOXO_KO_w 3.68 0.217 99.9 1228.625 1228.628 -2.7 172496.6IPI:IPI00 1 1 1.60% 1551 176432 5.6 U Tax_Id=10090 Gene_Symbol=Uggt1 UDP-glucose:glycoprotein glucosyltransferase 1 * FOXO_KO.4 5.9385 0.4139 100 2954.539 2952.535 -0.9 74405IPI:IPI00 1 1 1.60% 1199 135081 7.4 U Tax_Id=10090 Gene_Symbol=Ap3d1 AP-3 complex subunit delta-1 * FOXO_KO.3 6.8073 0.3861 100 2101.038 2101.041 -1.4 93343.3IPI:IPI00 1 1 1.60% 966 109404 6.2 U Tax_Id=10090 Gene_Symbol=Ganab Isoform 2 of Neutral alpha-glucosidase AB IPI:IPI00 1 1 1.60% 944 106911 6.1 U Tax_Id=10090 Gene_Symbol=Ganab Isoform 1 of Neutral alpha-glucosidase AB

FOXO_KO.1 3.1009 0.3586 99.9 1636.767 1636.77 -1.8 177114.8IPI:IPI00 1 1 1.60% 951 108687 7.6 U Tax_Id=10090 Gene_Symbol=Xrn2 Isoform 1 of 5'-3' exoribonuclease 2 IPI:IPI00 1 1 1.60% 947 108108 7.3 U Tax_Id=10090 Gene_Symbol=Xrn2 Isoform 2 of 5'-3' exoribonuclease 2

FOXO_KO.4 6.0404 0.5792 100 1875.835 1874.83 1.1 118965.6IPI:IPI00 1 3 1.60% 795 91007 7.5 U Tax_Id=10090 Gene_Symbol=Dhx15 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 IPI:IPI00 1 3 1.80% 703 79971 7.3 U Tax_Id=10090 Gene_Symbol=Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 isoform 1

FOXO_KO.1 4.1729 0.4576 100 1386.682 1385.679 -0.8 338007.2IPI:IPI00 1 1 1.60% 551 59741 8.3 U Tax_Id=10090 Gene_Symbol=Krt75 Keratin, type II cytoskeletal 75 IPI:IPI00 1 1 1.70% 538 58224 8.3 U Tax_Id=10090 Gene_Symbol=4732456N10Rik hypothetical protein LOC239673

FOXO_KO_w 2.3764 0.3478 100 1079.513 1079.512 1.5 20194.2

IPI:IPI001 2 2 1.50% 2559 290543 6 U Tax_Id=10090 Gene_Symbol=Usp9x Probable ubiquitin carboxyl-terminal hydrolase FAF-X FOXO_KO.5 3.6111 0.3696 99.9 2810.489 2809.473 4.5 28570.9FOXO_KO.3 4.493 0.3793 100 1745.877 1744.875 -0.9 230162.2

IPI:IPI00 1 2 1.50% 1391 155117 6.2 U Tax_Id=10090 Gene_Symbol=Nup155 Nuclear pore complex protein Nup155 * FOXO_KO.3 5.8307 0.4735 100 2236.078 2234.082 -4.7 111906.7IPI:IPI00 1 2 1.50% 1295 143131 8.9 U Tax_Id=10090 Gene_Symbol=Rrp12 RRP12-like protein * FOXO_KO.1 6.0176 0.5965 100 2123.94 2123.944 -2.1 59700.3IPI:IPI00 1 1 1.50% 860 98774 7.8 U Tax_Id=10090 Gene_Symbol=Nop14 Nucleolar protein 14

FOXO_KO.2 3.9676 0.3691 100 1593.656 1593.659 -2.3 214048.2IPI:IPI00 1 2 1.50% 594 62845 8.4 U Tax_Id=10090 Gene_Symbol=Krt76 Keratin, type II cytoskeletal 2 oral * FOXO_KO_w 2.8589 0.3307 99.9 1065.52 1065.521 -1.1 136226.1IPI:IPI00 1 1 1.40% 1457 164185 5.9 U Tax_Id=10090 Gene_Symbol=Ptprk Receptor-type tyrosine-protein phosphatase kappa * FOXO_KO.1 5.4611 0.4747 100 2310.172 2310.171 0.4 84081.2IPI:IPI00 1 1 1.40% 1334 145310 4.8 U Tax_Id=10090 Gene_Symbol=D6Wsu116e Isoform 1 of WASH complex subunit FAM21 IPI:IPI008 1 1 1.50% 1248 136081 4.7 U Tax_Id=10090 Gene_Symbol=D6Wsu116e Isoform 2 of WASH complex subunit FAM21

FOXO_KO.3 5.5248 0.5317 100 2185.972 2184.982 -5.9 43065.7IPI:IPI00 1 2 1.40% 1178 134192 7.1 U Tax_Id=10090 Gene_Symbol=Lars Leucyl-tRNA synthetase, cytoplasmic * FOXO_KO.2 5.0609 0.4533 100 1810.841 1809.84 -1.2 154951.1IPI:IPI006 1 2 1.40% 1164 125616 7.1 U Tax_Id=10090 Gene_Symbol=Dhx9 Isoform 3 of ATP-dependent RNA helicase A IPI:IPI008 1 2 1.20% 1380 149474 6.8 U Tax_Id=10090 Gene_Symbol=Dhx9 Isoform 1 of ATP-dependent RNA helicase A

FOXO_KO.2 5.2781 0.3062 100 1743.865 1741.86 -0.9 152809IPI:IPI00 1 1 1.40% 1024 110726 7.5 U Tax_Id=10090 Gene_Symbol=Mthfd1l 111 kDa protein IPI:IPI00 1 1 1.40% 977 105729 7 U Tax_Id=10090 Gene_Symbol=Mthfd1l Monofunctional C1-tetrahydrofolate synthase, mitochondrial

FOXO_KO.3 5.0001 0.455 100 1563.834 1562.831 -0.5 289854.3IPI:IPI00 1 2 1.40% 765 86162 7.1 U Tax_Id=10090 Gene_Symbol=Sec23a Protein transport protein Sec23A * FOXO_KO_w 3.52 0.3086 100 1342.64 1342.639 1 31392contamina 1 1 1.40% 638 65871 8.1 U no descriptioncontamina 1 1 1.40% 629 64511 6.5 U no description

FOXO_KO.1 2.9985 0.1926 99.7 1141.552 1139.54 4.4 309857.1IPI:IPI00 3 4 1.30% 2431 273988 5 U Tax_Id=10090 Gene_Symbol=Tpr nuclear pore complex-associated protein Tpr * FOXO_KO.1 4.2486 0.409 100 1573.789 1572.786 -0.6 226297.8* FOXO_KO.3 5.4748 0.3955 100 2154.173 2153.17 -0.3 109543.9* FOXO_KO.3 4.0653 0.3086 99.9 2154.171 2153.17 -0.9 149472.3IPI:IPI006 1 1 1.30% 2265 253317 7.8 U Tax_Id=10090 Gene_Symbol=Setx Isoform 2 of Probable helicase senataxin

FOXO_KO.1 4.9064 0.376 99.9 3265.549 3264.55 -1.6 59811IPI:IPI00 1 1 1.30% 1335 149875 7.8 U Tax_Id=10090 Gene_Symbol=Dhx57 Isoform 2 of Putative ATP-dependent RNA helicase DHX57 IPI:IPI00 1 1 1.70% 1025 114839 7.1 U Tax_Id=10090 Gene_Symbol=Dhx57 Isoform 3 of Putative ATP-dependent RNA helicase DHX57 IPI:IPI00 1 1 1.20% 1388 155762 7.9 U Tax_Id=10090 Gene_Symbol=Dhx57 Isoform 1 of Putative ATP-dependent RNA helicase DHX57

FOXO_KO.6 4.4956 0.4138 100 1955.09 1954.09 -1.6 47471.1IPI:IPI00 1 1 1.30% 1040 117636 6.4 U Tax_Id=10090 Gene_Symbol=Skiv2l2 Superkiller viralicidic activity 2-like 2 IPI:IPI00 1 1 5.80% 242 26644 5.1 U Tax_Id=10090 Gene_Symbol=Skiv2l2 Putative uncharacterized protein

FOXO_KO.2 3.7959 0.4122 100 1534.726 1534.727 -0.8 170335.6IPI:IPI004 1 1 1.30% 713 81475 7 U Tax_Id=10090 Gene_Symbol=Ssrp1 Isoform 2 of FACT complex subunit SSRP1 IPI:IPI00 1 1 1.30% 713 81377 6.8 U Tax_Id=10090 Gene_Symbol=Ssrp1 81 kDa protein IPI:IPI00 1 1 1.40% 623 71528 6 U Tax_Id=10090 Gene_Symbol=Ssrp1 Structure specific recognition protein 1 IPI:IPI006 1 1 1.30% 708 80860 6.8 U Tax_Id=10090 Gene_Symbol=Ssrp1 Isoform 1 of FACT complex subunit SSRP1

FOXO_KO.2 2.6415 0.3938 100 1115.526 1115.526 0.3 121572.5IPI:IPI004 1 1 1.20% 2541 269831 6.1 U Tax_Id=10090 Gene_Symbol=Tln1 Talin-1

IPI:IPI00 1 1 1.20% 2541 269819 6.2 U Tax_Id=10090 Gene_Symbol=Tln1 talin 1 FOXO_KO.5 4.687 0.4441 100 3052.522 3051.516 0.8 65747.1

IPI:IPI00 1 1 1.20% 2202 251028 7 U Tax_Id=10090 Gene_Symbol=Ascc3 activating signal cointegrator 1 complex subunit 3 isoform 2 * FOXO_KO.4 3.8936 0.3603 99.9 3008.489 3007.481 1.2 47472.1IPI:IPI00 1 1 1.20% 2225 243236 6.4 U Tax_Id=10090 Gene_Symbol=Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IPI:IPI00 1 1 1.20% 2162 236247 6.5 U Tax_Id=10090 Gene_Symbol=Cad Cad-pending protein IPI:IPI00 1 1 2.70% 971 105685 6.3 U Tax_Id=10090 Gene_Symbol=Cad Cad protein

FOXO_KO.2 4.0378 0.422 99.9 2681.269 2680.263 0.8 103626.2IPI:IPI00 1 1 1.20% 1150 128328 8.8 U Tax_Id=10090 Gene_Symbol=Dhx37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 * FOXO_KO.1 3.7396 0.2415 99.9 1633.806 1633.807 -0.2 381280.1IPI:IPI00 3 3 1.00% 4644 532030 6.4 U Tax_Id=10090 Gene_Symbol=Dync1h1 Cytoplasmic dynein 1 heavy chain 1 * FOXO_KO.3 4.6184 0.4235 100 2463.343 2462.339 0.4 201955.1* FOXO_KO.4 5.9029 0.4981 100 2335.249 2334.244 0.5 155315.2* FOXO_KO.6 3.0295 0.2829 99.5 2787.481 2787.46 7.4 59338.9IPI:IPI00 1 1 1.00% 1969 216131 6.1 U Tax_Id=10090 Gene_Symbol=Parp4 poly (ADP-ribose) polymerase family, member 4 * FOXO_KO.3 3.2642 0.2352 99.5 2281.068 2280.067 -0.8 165533.1IPI:IPI00 2 2 0.90% 5430 619491 5.4 U Tax_Id=10090 Gene_Symbol=Macf1 microtubule-actin crosslinking factor 1 IPI:IPI00 2 2 0.80% 5895 663292 5.3 U Tax_Id=10090 Gene_Symbol=Macf1 Microtubule-actin crosslinking factor 1

FOXO_KO.5 2.8826 0.3363 99.7 3145.578 3144.579 -1.4 43441.7FOXO_KO.4 3.9881 0.2527 99.9 2234.104 2234.086 8.1 55141.2

IPI:IPI00 1 2 0.90% 3364 369731 5.1 U Tax_Id=10090 Gene_Symbol=Huwe1 Isoform 2 of E3 ubiquitin-protein ligase HUWE1 IPI:IPI00 1 2 0.70% 4377 482640 5.2 U Tax_Id=10090 Gene_Symbol=Huwe1 HECT, UBA and WWE domain containing 1 IPI:IPI00 1 2 0.70% 4378 482697 5.2 U Tax_Id=10090 Gene_Symbol=Huwe1 HECT, UBA and WWE domain containing 1 IPI:IPI00 1 2 0.80% 3832 419526 5.2 U Tax_Id=10090 Gene_Symbol=Huwe1 Isoform 4 of E3 ubiquitin-protein ligase HUWE1

FOXO_KO.4 5.6263 0.457 100 3185.556 3183.555 -1.9 141151.6IPI:IPI00 1 1 0.90% 2170 243159 6.9 U Tax_Id=10090 Gene_Symbol=Svil Supervillin IPI:IPI00 1 1 2.50% 749 84971 7.4 U Tax_Id=10090 Gene_Symbol=Svil Protein IPI:IPI00 1 1 0.90% 2056 230424 6.6 U Tax_Id=10090 Gene_Symbol=Svil 230 kDa protein IPI:IPI00 1 1 1.10% 1766 198527 6.5 U Tax_Id=10090 Gene_Symbol=Svil Svil protein IPI:IPI00 1 1 0.90% 2031 226812 7.9 U Tax_Id=10090 Gene_Symbol=Svil Archvillin

FOXO_KO.4 4.5464 0.4915 100 2210.054 2210.054 0.1 65803.1IPI:IPI00 1 6 0.90% 1938 223355 5.5 U Tax_Id=10090 Gene_Symbol=Myh11 smooth muscle myosin heavy chain 11 isoform 1

FOXO_KO.2 6.6273 0.4815 100 1962.925 1961.919 1.7 105101IPI:IPI00 1 1 0.80% 1599 170376 5.3 U Tax_Id=10090 Gene_Symbol=Ankrd17 Isoform 3 of Ankyrin repeat domain-containing protein 17 IPI:IPI00 1 1 0.50% 2603 274211 6.5 U Tax_Id=10090 Gene_Symbol=Ankrd17 Isoform 1 of Ankyrin repeat domain-containing protein 17 IPI:IPI00 1 1 0.60% 2352 246622 6.7 U Tax_Id=10090 Gene_Symbol=Ankrd17 ankyrin repeat domain protein 17 isoform b

FOXO_KO.3 3.1346 0.3069 99.9 1486.799 1486.8 -0.4 150346.4IPI:IPI00 1 1 0.70% 2335 273615 8.8 U Tax_Id=10090 Gene_Symbol=Prpf8 Pre-mRNA-processing-splicing factor 8 IPI:IPI00 1 1 1.60% 1044 123550 9.2 U Tax_Id=10090 Gene_Symbol=Prpf8 Pre-mRNA processing factor 8

FOXO_KO.2 6.0936 0.457 100 2122.938 2121.936 -0.5 79560.7IPI:IPI005 2 3 0.60% 5656 604265 6.3 U Tax_Id=10090 Gene_Symbol=Ahnak AHNAK nucleoprotein isoform 1 * FOXO_KO.2 4.9499 0.4413 100 2041.947 2040.943 0.2 129715* FOXO_KO.1 3.4576 0.2757 99.9 1667.831 1666.828 -0.4 165417.7IPI:IPI00 1 1 0.60% 2846 310891 9.1 U Tax_Id=10090 Gene_Symbol=Bat2l2 HLA-B associated transcript 2-like 2 IPI:IPI009 1 1 0.60% 2828 308903 9 U Tax_Id=10090 Gene_Symbol=Bat2l2 Isoform 1 of Protein BAT2-like 2 IPI:IPI00 1 1 0.70% 2586 283081 9 U Tax_Id=10090 Gene_Symbol=Bat2l2 Isoform 3 of Protein BAT2-like 2 IPI:IPI00 1 1 0.70% 2749 300616 8.9 U Tax_Id=10090 Gene_Symbol=Bat2l2 Isoform 5 of Protein BAT2-like 2

FOXO_KO.1 5.5124 0.4774 100 2020.865 2020.867 -0.5 93623.5

IPI:IPI00 1 1 0.60% 2671 293018 7.4 U Tax_Id=10090 Gene_Symbol=Gcn1l1 GCN1 general control of amino-acid synthesis 1-like 1 IPI:IPI00 1 1 1.50% 1054 115425 6.4 U Tax_Id=10090 Gene_Symbol=Gcn1l1 Putative uncharacterized protein IPI:IPI00 1 1 0.60% 2602 286114 7.1 U Tax_Id=10090 Gene_Symbol=LOC100047016 similar to GCN1 general control of amino-acid synthesis 1-like 1

FOXO_KO.2 2.6758 0.2766 99.6 1807.86 1807.86 0.3 128254.3IPI:IPI001 1 1 0.60% 2464 270409 4.8 U Tax_Id=10090 Gene_Symbol=Mtap1b Microtubule-associated protein 1B

FOXO_KO.3 3.8666 0.3556 100 1977.924 1977.922 1 83840.4IPI:IPI00 1 1 0.60% 1946 222513 6.2 U Tax_Id=10090 Gene_Symbol=Chd5 chromodomain helicase DNA binding protein 5 isoform 2 IPI:IPI00 1 1 0.60% 1952 222683 6.1 U Tax_Id=10090 Gene_Symbol=Chd5 chromodomain helicase DNA binding protein 5 isoform1

FOXO_KO.1 3.4136 0.2936 99.9 1472.657 1470.65 0.6 254773.4IPI:IPI00 1 1 0.50% 5478 622195 5.4 U Tax_Id=10090 Gene_Symbol=Macf1 Isoform 3 of Microtubule-actin cross-linking factor 1 IPI:IPI00 1 1 0.50% 5270 601781 5.5 U Tax_Id=10090 Gene_Symbol=Macf1 Isoform 1 of Microtubule-actin cross-linking factor 1 IPI:IPI00 1 1 0.50% 5478 622327 5.4 U Tax_Id=10090 Gene_Symbol=Macf1 Isoform 2 of Microtubule-actin cross-linking factor 1 IPI:IPI00 1 1 0.40% 7354 831956 5.4 U Tax_Id=10090 Gene_Symbol=Macf1 Microtubule-actin crosslinking factor 1b IPI:IPI00 1 1 0.60% 4466 508379 5.4 U Tax_Id=10090 Gene_Symbol=Macf1 Microtubule-actin crosslinking factor 1

FOXO_KO.5 2.8826 0.3363 99.7 3145.578 3144.579 -1.4 43441.7IPI:IPI00 1 1 0.50% 5180 572298 6.1 U Tax_Id=10090 Gene_Symbol=Ubr4 Isoform 1 of E3 ubiquitin-protein ligase UBR4 IPI:IPI00 1 1 0.50% 5156 570308 6.1 U Tax_Id=10090 Gene_Symbol=Ubr4 Isoform 3 of E3 ubiquitin-protein ligase UBR4 IPI:IPI00 1 1 0.50% 5208 575184 6 U Tax_Id=10090 Gene_Symbol=Ubr4 Isoform 5 of E3 ubiquitin-protein ligase UBR4

FOXO_KO.5 4.5123 0.3971 99.9 2770.445 2768.429 3.4 32246.4IPI:IPI00 1 1 0.50% 4912 559576 6.9 U Tax_Id=10090 Gene_Symbol=- Ring finger protein 213 * FOXO_KO.4 4.3936 0.4504 100 2894.359 2892.344 3.2 85309.9IPI:IPI00 1 1 0.50% 4965 532356 6 U Tax_Id=10090 Gene_Symbol=Mll2 similar to myeloid/lymphoid or mixed-lineage leukemia 2 IPI:IPI007 1 1 0.40% 5274 565874 6.2 U Tax_Id=10090 Gene_Symbol=Mll2 myeloid/lymphoid or mixed-lineage leukemia 2 IPI:IPI00 1 1 0.40% 5588 600253 5.8 U Tax_Id=10090 Gene_Symbol=Mll2 myeloid/lymphoid or mixed-lineage leukemia 2

FOXO_KO.3 2.8781 0.2999 99.5 2964.509 2964.487 7.3 74423.2IPI:IPI00 1 1 0.50% 2448 275748 6.3 U Tax_Id=10090 Gene_Symbol=Acacb acetyl-Coenzyme A carboxylase beta IPI:IPI00 1 1 0.50% 2383 269956 6.5 U Tax_Id=10090 Gene_Symbol=Acaca Isoform 2 of Acetyl-CoA carboxylase 1 IPI:IPI00 1 1 0.60% 2345 265254 6.4 U Tax_Id=10090 Gene_Symbol=Acaca Isoform 1 of Acetyl-CoA carboxylase 1

FOXO_KO.1 4.0763 0.4743 100 1571.695 1571.697 -1.5 150430.3IPI:IPI00 1 3 0.40% 4548 517985 5.8 U Tax_Id=10090 Gene_Symbol=Plec plectin isoform 1b2alpha IPI:IPI00 1 3 0.40% 4572 519761 5.8 U Tax_Id=10090 Gene_Symbol=Plec plectin isoform 1c IPI:IPI00 1 3 0.40% 4691 534193 6 U Tax_Id=10090 Gene_Symbol=Plec plectin isoform 12alpha IPI:IPI00 1 3 0.40% 4543 517333 5.8 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1B of Plectin-1 IPI:IPI00 1 3 0.40% 4526 515543 5.8 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1E of Plectin-1 IPI:IPI00 1 3 0.40% 4534 516472 5.7 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1F of Plectin-1 IPI:IPI00 1 3 0.40% 4686 533541 5.9 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1 of Plectin-1 IPI:IPI00 1 3 0.40% 4511 513766 5.8 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1D of Plectin-1 IPI:IPI00 1 3 0.40% 4543 517320 5.8 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1A of Plectin-1 IPI:IPI00 1 3 0.40% 4550 518131 5.8 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1G of Plectin-1 IPI:IPI00 1 3 0.40% 4449 506460 5.7 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1H of Plectin-1 IPI:IPI00 1 3 0.40% 4589 521946 5.8 U Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-0 of Plectin-1

FOXO_KO.3 6.3413 0.4587 100 2170.953 2168.954 -3.3 82651.2IPI:IPI00 2 2 0.30% 6548 724679 6.1 U Tax_Id=10090 Gene_Symbol=Eppk1 Epiplakin * FOXO_KO.6 7.4129 0.5286 100 2303.228 2302.221 1.7 88206.5* FOXO_KO.6 4.4068 0.4346 100 2303.228 2302.221 1.4 69234.3

Proteins Peptide ID SpectraUnfiltered 64867 102815 216019Filtered 1340 2839 4659

Forward m 1340 2839 4659Decoy mat 0 0 0Forward F 0 0 0

Classificat NonredundaRedundant ProteinsUnclassifie 0 0

Descriptive NameSpR Prob Score pI IonProportRedundancSequence

Tax_Id=10090 Gene_Symbol=Rplp2 60S acidic ribosomal protein P2 1 7.620815 4.25 100 1 K.KILDSVGIEADDDR.L1 9.496922 4.57 80.8 1 K.KILDSVGIEADDDRLNK.V1 6.782508 4.57 61.2 2 K.KILDSVGIEADDDRLNK.V1 8.282949 3.86 95.5 1 K.ILDSVGIEADDDR.L1 7.756226 4.25 96 2 K.ILDSVGIEADDDRLNK.V2 5.908978 4.42 37.2 1 K.ILDSVGIEADDDRLNKVISELNGKNIEDVIAQGVGK.L1 7.09218 4.46 94.1 1 K.NIEDVIAQGVGK.L1 8.061486 4.46 95 1 K.NIEDVIAQGVGK.L

37 4.413512 4.89 31.6 1 K.LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK.K1 8.301945 3.64 70.4 1 K.KEESEESDDDMGFGLFD.-1 7.977026 3.64 64 1 K.KEES(79.9663)EES(79.9663)DDDMGFGLFD.-

Tax_Id=10090 Gene_Symbol=Actb Beta-actin (Fragment) 1 9.645959 6.56 100 1 -.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.S1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.S

1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.S1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F

Tax_Id=10090 Gene_Symbol=Foxo1 forkhead box O1 1 9.505569 3.86 85.7 1 S.AVSTDFMSNLSLLEESEDFAR.A1 8.28092 8.26 95.8 2 R.APGCVAVAAAAAASR.G1 8.148067 8.8 96.2 1 R.RNAWGNLSYADLITK.A1 6.872889 8.8 82.6 1 R.RNAWGNLS(79.9663)YADLITK.A1 7.137658 6.56 86.4 2 R.NAWGNLSYADLITK.A1 5.983445 6.56 86.4 1 R.NAWGNLSY(79.9663)ADLITK.A1 7.37436 4.72 64.5 1 R.NAWGNLSYADLITKAIESSAEK.R1 8.014863 6.56 80.8 1 K.AIESSAEKRLTLSQIYEWMVK.S1 6.636292 8.8 72.7 1 K.RLTLSQIYEWMVK.S4 5.206337 8.8 60 2 K.RLTLSQIYEWMVK.S1 6.684074 8.8 85 1 K.RLTLSQIY(79.9663)EWMVK.S1 6.35558 8.8 90.5 2 K.RLT(79.9663)LSQIYEWMVK.S1 7.646252 8.8 85.7 1 K.RLTLS(79.9663)QIYEWMVK.S1 7.554637 6.56 94.7 1 R.LTLSQIYEWMVK.S1 5.657563 6.56 94.1 1 R.LTLSQIY(79.9663)EWMVK.S1 6.266202 6.56 84.2 1 R.LTLS(79.9663)QIYEWMVK.S1 8.67656 8.7 72.4 1 K.SVPYFKDKGDSNSSAGWK.N1 6.083241 6.56 94.1 4 K.DKGDSNSSAGWK.N1 6.413917 6.56 100 7 K.DKGDSNSSAGWK.N1 6.32866 8.8 92.3 2 K.DKGDSNSSAGWKNSIR.H1 5.828032 8.8 77.8 2 K.DKGDSNSSAGWKNS(79.9663)IR.H1 9.891484 6.56 86.7 1 R.VQNEGTGKSSWWMLNPEGGK.S1 6.024244 6.56 93.3 1 K.SSWWMLNPEGGK.S1 7.479659 6.56 100 1 K.SSWWMLNPEGGK.S1 5.050571 6.56 88.9 1 K.SS(79.9663)WWMLNPEGGK.S1 6.161823 9.98 74.1 1 K.SSWWMLNPEGGKSGKS(79.9663)PR.R7 4.882958 9.98 50 1 K.SSWWMLNPEGGKSGKS(79.9663)PR.R1 7.032366 8.64 52.5 1 K.KKASLQSGQEGPGDSPGSQFSK.W1 6.477624 8.64 68.8 1 K.KKAS(79.9663)LQSGQEGPGDSPGSQFSK.W2 4.590595 8.64 54.4 1 K.KKASLQSGQEGPGDSPGS(79.9663)QFSK.W1 10.26463 6.56 85.7 2 K.KASLQSGQEGPGDSPGSQFSK.W1 8.979454 6.56 77.4 1 K.KASLQSGQEGPGDS(79.9663)PGSQFSK.W1 9.335766 6.56 75.8 1 K.KAS(79.9663)LQSGQEGPGDSPGSQFSK.W1 6.816145 6.56 70.2 1 K.KASLQSGQEGPGDS(79.9663)PGSQFSK.W1 9.225834 4.46 75 1 K.ASLQSGQEGPGDS(79.9663)PGSQFSK.W1 7.661023 4.46 62.3 1 K.ASLQSGQEGPGDS(79.9663)PGSQFSK.W1 7.609515 4.72 59.3 2 K.WPAS(79.9663)PGSHSNDDFDNWSTFR.P4 6.535822 4.72 48.1 4 K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.P1 7.896728 4.72 66.7 1 K.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFR.P

15 5.286351 4.72 42.3 1 K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.P4 6.293928 5.8 53.8 2 K.WPASPGSHSNDDFDNWSTFRPR.T4 6.326823 5.8 41.9 2 K.WPASPGSHSNDDFDNWSTFRPR.T1 5.978352 5.8 65.4 1 K.WPASPGS(79.9663)HSNDDFDNWSTFRPR.T

16 3.980081 5.8 36.5 1 K.WPASPGSHS(79.9663)NDDFDNWSTFRPR.T1 4.92144 5.8 45.9 6 K.WPAS(79.9663)PGSHSNDDFDNWSTFRPR.T

3 6.618515 5.8 53.3 2 K.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFRPR.T1 4.602723 5.8 38.5 1 K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFRPR.T1 6.379817 10.06 84.2 1 R.TSS(79.9663)NASTISGR.L1 8.771044 4.25 46.5 1 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVH.S1 10.82258 4.25 47.3 1 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSL.V

38 6.499691 4.58 31 4 R.TSSNAS(79.9663)TISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M12 6.16806 4.58 33 3 R.TSSNASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M49 4.562479 4.58 29.9 1 R.TSSNAST(79.9663)ISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

4 6.257974 4.58 33.7 1 R.TSSNASTISGRLSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.M1 5.134823 4.58 38.6 2 R.TSS(79.9663)NASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

13 5.289767 4.58 33.3 2 R.TS(79.9663)SNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M47 6.708209 4.58 29.7 20 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M42 4.52221 4.58 30.7 2 R.T(79.9663)SSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

1 5.769721 4.58 36.1 10 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M60 5.279177 4.58 25.9 1 R.TSSNASTISGRLS(79.9663)PIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.M

2 7.816215 4.58 45 1 N.ASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M1 6.776695 3.34 81.2 1 R.LSPIMTEQDDLGD.G1 10.15639 3.86 90 1 R.LSPIMTEQDDLGDGDVHSL.V1 8.454705 4.25 86.7 2 R.LSPIMTEQDDLGDGDVHSLVYPPSAAK.M1 7.237877 4.25 44.9 4 R.LSPIMTEQDDLGDGDVHSLVYPPSAAK.M1 7.061469 4.25 65.5 2 R.LSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.M2 4.849286 4.25 42 1 R.LS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M1 7.836328 6.56 82.8 1 K.YTYGQSSMSPLPQMPMQTLQDSK.S1 5.083098 6.56 57.1 1 K.YTYGQSSMSPLPQMPMQTLQDSK.S4 4.565258 6.56 50 3 K.YTYGQSSMS(79.9663)PLPQMPMQTLQDSK.S

13 5.557863 6.56 32.1 1 K.YTYGQSS(79.9663)MSPLPQMPMQTLQDSK.S1 7.976195 8.22 71.4 2 K.SSYGGLNQYNCAPGLLK.E1 6.619216 4.4 58.6 2 K.ELLTSDSPPHNDIMSPVDPGVAQPNSR.V

45 5.505474 4.4 33.3 1 K.ELLTSDSPPHNDIMSPVDPGVAQPNSR.V12 5.211672 4.4 28.6 1 K.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.V

2 5.270329 4.4 39.3 1 K.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.V53 4.541462 4.4 31.5 1 K.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.V

1 6.603883 4.4 40.5 2 K.ELLTSDS(79.9663)PPHNDIMSPVDPGVAQPNSR.V1 7.187491 4.4 45.2 3 K.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.V1 4.841341 4.4 46.4 1 K.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.V9 5.561042 4.4 35.6 2 K.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.V1 9.591818 8.8 70 2 R.VLGQNVMMGPNSVMPAYGSQASHNK.M

48 7.18294 8.8 36.9 2 R.VLGQNVMMGPNSVMPAYGSQASHNK.M3 5.467681 8.8 49.3 1 R.VLGQNVMMGPNSVMPAYGSQAS(79.9663)HNK.M2 6.232196 8.8 56.7 2 R.VLGQNVMMGPNSVMPAYGS(79.9663)QASHNK.M1 5.711002 10.06 52 1 R.TLPHVVNTMPHTSAMNR.L2 5.023656 10.99 64.3 1 R.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.T1 5.017124 10.99 46.7 1 R.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.T

33 5.863264 9.02 31.4 1 R.LTPVKT(79.9663)PLQVPLSHPMQMSALGSYSSVSSCNGYGR.M47 6.141857 8.26 32.1 1 K.TPLQVPLSHPMQMSALGSYSSVSSCNGYGR.M

1 6.870011 4.89 71.4 7 R.MGVLHQEKLPSDLDGMFIER.L1 6.678754 4.89 66.7 1 R.MGVLHQEKLPS(79.9663)DLDGMFIER.L1 4.747642 4.89 60 1 R.MGVLHQEKLPS(79.9663)DLDGMFIER.L

6 4.487725 4.53 35.1 1 R.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.N3 4.61074 4.53 34.7 1 R.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.N1 5.235511 4.14 95 3 K.LPSDLDGMFIER.L1 5.903818 4.14 100 1 R.LDCDMESIIR.N1 5.400583 4.14 87.5 1 R.LDCDMES(79.9663)IIR.N1 5.151503 4.2 35.4 1 R.LDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVK.T

Tax_Id=10090 Gene_Symbol=Foxo1 Forkhead box protein O1 1 9.505569 3.86 85.7 1 S.AVSTDFMSNLSLLEESEDFAR.A1 8.28092 8.26 95.8 2 R.APGCVAVAAAAAASR.G1 8.148067 8.8 96.2 1 R.RNAWGNLSYADLITK.A1 6.872889 8.8 82.6 1 R.RNAWGNLS(79.9663)YADLITK.A1 7.137658 6.56 86.4 2 R.NAWGNLSYADLITK.A1 5.983445 6.56 86.4 1 R.NAWGNLSY(79.9663)ADLITK.A1 7.37436 4.72 64.5 1 R.NAWGNLSYADLITKAIESSAEK.R1 8.014863 6.56 80.8 1 K.AIESSAEKRLTLSQIYEWMVK.S1 6.636292 8.8 72.7 1 K.RLTLSQIYEWMVK.S4 5.206337 8.8 60 2 K.RLTLSQIYEWMVK.S1 6.684074 8.8 85 1 K.RLTLSQIY(79.9663)EWMVK.S1 6.35558 8.8 90.5 2 K.RLT(79.9663)LSQIYEWMVK.S1 7.646252 8.8 85.7 1 K.RLTLS(79.9663)QIYEWMVK.S1 7.554637 6.56 94.7 1 R.LTLSQIYEWMVK.S1 5.657563 6.56 94.1 1 R.LTLSQIY(79.9663)EWMVK.S1 6.266202 6.56 84.2 1 R.LTLS(79.9663)QIYEWMVK.S1 8.67656 8.7 72.4 1 K.SVPYFKDKGDSNSSAGWK.N1 6.083241 6.56 94.1 4 K.DKGDSNSSAGWK.N1 6.413917 6.56 100 7 K.DKGDSNSSAGWK.N1 6.32866 8.8 92.3 2 K.DKGDSNSSAGWKNSIR.H1 5.828032 8.8 77.8 2 K.DKGDSNSSAGWKNS(79.9663)IR.H1 9.891484 6.56 86.7 1 R.VQNEGTGKSSWWMLNPEGGK.S1 6.024244 6.56 93.3 1 K.SSWWMLNPEGGK.S1 7.479659 6.56 100 1 K.SSWWMLNPEGGK.S1 5.050571 6.56 88.9 1 K.SS(79.9663)WWMLNPEGGK.S1 6.161823 9.98 74.1 1 K.SSWWMLNPEGGKSGKS(79.9663)PR.R7 4.882958 9.98 50 1 K.SSWWMLNPEGGKSGKS(79.9663)PR.R1 7.032366 8.64 52.5 1 K.KKASLQSGQEGPGDSPGSQFSK.W1 6.477624 8.64 68.8 1 K.KKAS(79.9663)LQSGQEGPGDSPGSQFSK.W2 4.590595 8.64 54.4 1 K.KKASLQSGQEGPGDSPGS(79.9663)QFSK.W1 10.26463 6.56 85.7 2 K.KASLQSGQEGPGDSPGSQFSK.W1 8.979454 6.56 77.4 1 K.KASLQSGQEGPGDS(79.9663)PGSQFSK.W1 9.335766 6.56 75.8 1 K.KAS(79.9663)LQSGQEGPGDSPGSQFSK.W1 6.816145 6.56 70.2 1 K.KASLQSGQEGPGDS(79.9663)PGSQFSK.W1 9.225834 4.46 75 1 K.ASLQSGQEGPGDS(79.9663)PGSQFSK.W1 7.661023 4.46 62.3 1 K.ASLQSGQEGPGDS(79.9663)PGSQFSK.W1 7.609515 4.72 59.3 2 K.WPAS(79.9663)PGSHSNDDFDNWSTFR.P4 6.535822 4.72 48.1 4 K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.P1 7.896728 4.72 66.7 1 K.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFR.P

15 5.286351 4.72 42.3 1 K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.P4 6.293928 5.8 53.8 2 K.WPASPGSHSNDDFDNWSTFRPR.T

4 6.326823 5.8 41.9 2 K.WPASPGSHSNDDFDNWSTFRPR.T1 5.978352 5.8 65.4 1 K.WPASPGS(79.9663)HSNDDFDNWSTFRPR.T

16 3.980081 5.8 36.5 1 K.WPASPGSHS(79.9663)NDDFDNWSTFRPR.T1 4.92144 5.8 45.9 6 K.WPAS(79.9663)PGSHSNDDFDNWSTFRPR.T3 6.618515 5.8 53.3 2 K.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFRPR.T1 4.602723 5.8 38.5 1 K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFRPR.T1 6.379817 10.06 84.2 1 R.TSS(79.9663)NASTISGR.L1 8.771044 4.25 46.5 1 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVH.S1 10.82258 4.25 47.3 1 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSL.V

38 6.499691 4.58 31 4 R.TSSNAS(79.9663)TISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M12 6.16806 4.58 33 3 R.TSSNASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M49 4.562479 4.58 29.9 1 R.TSSNAST(79.9663)ISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

4 6.257974 4.58 33.7 1 R.TSSNASTISGRLSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.M1 5.134823 4.58 38.6 2 R.TSS(79.9663)NASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

13 5.289767 4.58 33.3 2 R.TS(79.9663)SNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M47 6.708209 4.58 29.7 20 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M42 4.52221 4.58 30.7 2 R.T(79.9663)SSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

1 5.769721 4.58 36.1 10 R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M60 5.279177 4.58 25.9 1 R.TSSNASTISGRLS(79.9663)PIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.M

2 7.816215 4.58 45 1 N.ASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M1 6.776695 3.34 81.2 1 R.LSPIMTEQDDLGD.G1 10.15639 3.86 90 1 R.LSPIMTEQDDLGDGDVHSL.V1 8.454705 4.25 86.7 2 R.LSPIMTEQDDLGDGDVHSLVYPPSAAK.M1 7.237877 4.25 44.9 4 R.LSPIMTEQDDLGDGDVHSLVYPPSAAK.M1 7.061469 4.25 65.5 2 R.LSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.M2 4.849286 4.25 42 1 R.LS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M1 7.836328 6.56 82.8 1 K.YTYGQSSMSPLPQMPMQTLQDSK.S1 5.083098 6.56 57.1 1 K.YTYGQSSMSPLPQMPMQTLQDSK.S4 4.565258 6.56 50 3 K.YTYGQSSMS(79.9663)PLPQMPMQTLQDSK.S

13 5.557863 6.56 32.1 1 K.YTYGQSS(79.9663)MSPLPQMPMQTLQDSK.S1 7.976195 8.22 71.4 2 K.SSYGGLNQYNCAPGLLK.E1 6.619216 4.4 58.6 2 K.ELLTSDSPPHNDIMSPVDPGVAQPNSR.V

45 5.505474 4.4 33.3 1 K.ELLTSDSPPHNDIMSPVDPGVAQPNSR.V12 5.211672 4.4 28.6 1 K.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.V

2 5.270329 4.4 39.3 1 K.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.V53 4.541462 4.4 31.5 1 K.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.V

1 6.603883 4.4 40.5 2 K.ELLTSDS(79.9663)PPHNDIMSPVDPGVAQPNSR.V1 7.187491 4.4 45.2 3 K.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.V1 4.841341 4.4 46.4 1 K.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.V9 5.561042 4.4 35.6 2 K.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.V1 9.591818 8.8 70 2 R.VLGQNVMMGPNSVMPAYGSQASHNK.M

48 7.18294 8.8 36.9 2 R.VLGQNVMMGPNSVMPAYGSQASHNK.M3 5.467681 8.8 49.3 1 R.VLGQNVMMGPNSVMPAYGSQAS(79.9663)HNK.M2 6.232196 8.8 56.7 2 R.VLGQNVMMGPNSVMPAYGS(79.9663)QASHNK.M1 5.711002 10.06 52 1 R.TLPHVVNTMPHTSAMNR.L2 5.023656 10.99 64.3 1 R.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.T1 5.017124 10.99 46.7 1 R.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.T

33 5.863264 9.02 31.4 1 R.LTPVKT(79.9663)PLQVPLSHPMQMSALGSYSSVSSCNGYGR.M

47 6.141857 8.26 32.1 1 K.TPLQVPLSHPMQMSALGSYSSVSSCNGYGR.M1 6.870011 4.89 71.4 7 R.MGVLHQEKLPSDLDGMFIER.L1 6.678754 4.89 66.7 1 R.MGVLHQEKLPS(79.9663)DLDGMFIER.L1 4.747642 4.89 60 1 R.MGVLHQEKLPS(79.9663)DLDGMFIER.L6 4.487725 4.53 35.1 1 R.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.N3 4.61074 4.53 34.7 1 R.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.N1 5.235511 4.14 95 3 K.LPSDLDGMFIER.L

58 4.663884 4.16 26.4 1 K.LPSDLDGMFIERLDCDMESIIRNDPMDGDTLDFNFDNVLPNQSFPHSVK.T1 5.903818 4.14 100 1 R.LDCDMESIIR.N1 5.400583 4.14 87.5 1 R.LDCDMES(79.9663)IIR.N1 5.396229 4.25 71.4 7 R.NDPMDGDTLDFNFDNVLPNQSFPHSVK.T1 5.349686 4.25 47.9 90 R.NDPMDGDTLDFNFDNVLPNQSFPHSVK.T1 6.032961 4.25 35 2 R.NDPMDGDTLDFNFDNVLPNQSFPHSVK.T1 4.274287 4.25 66.7 1 R.NDPMDGDTLDFNFDNVLPNQSFPHS(79.9663)VK.T1 5.019563 4.25 42.6 1 R.NDPMDGDTLDFNFDNVLPNQS(79.9663)FPHSVK.T1 8.003357 4.4 77.4 7 D.PMDGDTLDFNFDNVLPNQSFPHSVK.T

Tax_Id=10090 Gene_Symbol=Ywhah 14-3-3 protein eta 1 7.661809 4.4 84.6 3 R.LAEQAERYDDMASAMK.A1 6.424296 4.4 76.2 1 R.LAEQAERYDDMASAMK.A1 6.777921 3.96 95.5 1 K.AVTELNEPLSNEDR.N1 6.20942 3.96 73 1 K.AVTELNEPLSNEDR.N1 8.454775 4.4 73.3 3 K.AVTELNEPLSNEDRNLLSVAYK.N3 5.660932 4.4 48.2 1 K.AVTELNEPLSNEDRNLLSVAYK.N

18 6.233867 4.42 41.5 2 R.EKIEKELETVCNDVLALLDK.F17 6.998042 4.25 48.3 1 K.IEKELETVCNDVLALLDK.F

1 8.066895 4.25 68 4 K.IEKELETVCNDVLALLDK.F1 8.01751 4.57 54 1 K.IEKELETVCNDVLALLDKFLIK.N1 7.365219 3.96 75 2 K.ELETVCNDVLALLDK.F1 5.098673 3.96 73.7 1 K.ELETVCNDVLALLDK.F1 8.114995 4.4 72.4 1 K.ELETVCNDVLALLDKFLIK.N1 6.405186 4.46 92.3 2 K.NCNDFQYESK.V2 5.784503 4.46 81.2 1 K.NCNDFQYESK.V1 4.974426 4.46 93.8 2 R.YLAEVASGEK.K1 5.409013 6.56 83.3 4 R.YLAEVASGEKK.N1 7.121117 4.89 58.2 6 K.KNSVVEASEAAYKEAFEISK.E1 10.61319 4.4 86.7 4 K.NSVVEASEAAYKEAFEISK.E1 8.400167 3.8 79.3 3 K.QAFDDAIAELDTLNEDSYK.D1 7.649846 4.03 56 2 K.QAFDDAIAELDTLNEDSYKDSTLIMQLLR.D1 8.578078 3.23 70 4 R.DNLTLWTSDQQDEEAGEGN.-

Tax_Id=10090 Gene_Symbol=Ywhae 14-3-3 protein epsilon 1 7.395886 4.25 80 1 K.LAEQAERYDEMVESMK.K1 6.943728 4.25 68.3 1 K.LAEQAERYDEMVESMK.K1 7.031632 4.57 70.4 1 K.LAEQAERYDEMVESMKK.V1 5.970022 4.57 69.8 1 K.LAEQAERYDEMVESMKK.V

43 4.478447 4.57 48.6 1 K.LAEQAERYDEMVESMKK.V1 6.368708 4.14 93.3 1 R.YDEMVESMK.K1 5.758876 4.72 100 4 R.YDEMVESMKK.V1 5.63318 4.72 68.8 9 R.YDEMVESMKK.V

1 7.478849 3.96 95 44 K.VAGMDVELTVEER.N1 6.428403 4.72 95 1 R.IISSIEQKEENK.G1 9.023167 4.57 75 2 R.IISSIEQKEENKGGEDK.L1 8.512102 5.02 86.2 1 R.IISSIEQKEENKGGEDKLK.M1 7.132406 4.14 100 1 K.LICCDILDVLDK.H1 6.022575 4.89 52.4 1 K.LICCDILDVLDKHLIPAANTGESK.V1 5.278493 7.33 95 1 K.HLIPAANTGESK.V1 6.271328 4.46 93.3 1 R.YLAEFATGNDR.K1 7.038268 6.56 80 1 R.YLAEFATGNDRK.E1 6.904108 4.89 57.6 3 R.YLAEFATGNDRKEAAENSLVAYK.A1 5.981007 4.46 93.3 1 K.EAAENSLVAYK.A1 9.33258 3.8 80.6 4 K.AAFDDAIAELDTLSEESYK.D1 9.335495 4.03 54.1 9 K.AAFDDAIAELDTLSEESYKDSTLIMQLLR.D1 8.502883 4.03 37.9 1 K.AAFDDAIAELDTLSEESYKDSTLIMQLLR.D1 7.378738 4.03 41.7 1 K.AAFDDAIAELDTLS(79.9663)EESYKDSTLIMQLLR.D1 10.23484 4.4 96.4 1 L.DTLSEESYKDSTLIMQLLR.D1 10.14575 3.86 96.6 1 R.DNLTLWTSDMQGDGEEQNK.E

24 5.124664 3.56 33.8 1 R.DNLTLWTSDMQGDGEEQNKEALQDVEDENQ.-35 4.320056 3.56 32.2 1 R.DNLTLWTSDMQGDGEEQNKEALQDVEDENQ.-

Tax_Id=10090 Gene_Symbol=Ywhag 14-3-3 protein gamma 1 6.947441 4.4 84.6 1 R.LAEQAERYDDMAAAMK.N1 8.013042 4.4 76.2 1 R.LAEQAERYDDMAAAMK.N1 7.843486 4.19 42.1 1 R.LAEQAERYDDMAAAMKNVTELNEPLSNEER.N1 7.1264 3.96 87 2 K.NVTELNEPLSNEER.N6 7.77204 3.96 59.5 3 K.NVTELNEPLSNEER.N1 10.95782 4.25 100 4 K.IEKELEAVCQDVLSLLDNYLIK.N1 6.350701 4.25 62.7 4 K.IEKELEAVCQDVLSLLDNYLIK.N1 9.628461 3.96 96.4 3 K.ELEAVCQDVLSLLDNYLIK.N1 4.655181 3.96 56.6 4 K.ELEAVCQDVLSLLDNYLIK.N4 4.768123 4.12 36 2 K.ELEAVCQDVLSLLDNYLIKNCSETQYESK.V1 5.99189 6.56 100 5 R.YLAEVATGEKR.A1 7.791295 5.63 50 2 R.LGLALNYSVFYYEIQNAPEQACHLAK.T1 9.753716 3.8 83.3 4 K.TAFDDAIAELDTLNEDSYK.D1 6.79035 3.8 55.2 1 K.TAFDDAIAELDTLNEDSYK.D1 9.392205 4.03 52.1 13 K.TAFDDAIAELDTLNEDSYKDSTLIMQLLR.D7 6.129947 4.03 31.5 1 K.TAFDDAIAELDTLNEDSYKDSTLIMQLLR.D2 4.892101 4.03 47.2 1 K.TAFDDAIAELDTLNEDS(79.9663)YKDSTLIMQLLR.D

30 5.279768 4.03 34.7 1 K.TAFDDAIAELDT(79.9663)LNEDSYKDSTLIMQLLR.D1 10.16668 3.23 75.9 2 R.DNLTLWTSDQQDDDGGEGNN.-

Tax_Id=10090 Gene_Symbol=Ywhaz 14-3-3 protein zeta/delta 1 7.331036 4.4 76.9 1 K.LAEQAERYDDMAACMK.S1 7.081261 4.4 66.7 1 K.LAEQAERYDDMAACMK.S1 7.23296 3.96 100 2 K.SVTEQGAELSNEER.N1 6.325334 4.42 65.4 1 R.EKIETELRDICNDVLSLLEK.F1 6.113974 4.42 56.6 4 R.EKIETELRDICNDVLSLLEK.F1 6.049581 4.25 81.5 4 K.IETELRDICNDVLSLLEK.F1 7.177131 4.42 43.7 2 K.IETELRDICNDVLSLLEKFLIPNASQPESK.V1 4.501529 4.14 95 1 R.DICNDVLSLLEK.F

1 5.081926 6.56 85 1 K.FLIPNASQPESK.V1 5.846799 4.72 100 2 R.YLAEVAAGDDKK.G1 6.328741 4.72 85 2 R.YLAEVAAGDDKK.G1 5.256918 4.42 41.6 1 R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.K1 4.280901 4.42 33.9 1 R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.K6 4.375668 4.73 36.3 1 R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISKK.E1 12.35918 4.72 96.6 1 K.KGIVDQSQQAYQEAFEISK.K1 5.009207 4.72 53.1 1 K.KGIVDQSQQAYQEAFEISK.K1 6.92062 4.14 82.2 1 K.GIVDQSQQAYQEAFEISK.K1 7.645829 3.8 51.6 1 K.TAFDEAIAELDTLSEESYK.D1 8.505126 3.8 56.9 1 K.TAFDEAIAELDTLSEESYK.D1 9.307062 4.03 58.1 5 K.TAFDEAIAELDTLSEESYKDSTLIMQLLR.D2 7.38207 4.03 34.1 1 K.TAFDEAIAELDTLSEESYKDSTLIMQLLR.D1 10.23484 4.4 96.4 1 L.DTLSEESYKDSTLIMQLLR.D1 12.74764 3.2 83.9 2 R.DNLTLWTSDTQGDEAEAGEGGEN.-

Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-1 of Protein phosphatase 1B 5 8.02733 4.95 38 7 R.VEMEDAHTAVVGIPHGLDNWSFFAVYDGHAGSR.V1 8.248051 5.52 67.9 1 R.VANYCSTHLLEHITTNEDFR.A1 6.79956 5.52 61.5 1 R.VANYCSTHLLEHITTNEDFR.A8 4.228804 4.46 70 1 K.SGSALEPSVESVK.T9 6.038026 7.16 46.4 1 R.NGQVCFSTQDHKPCNPVEK.E

43 5.01635 7.16 40 1 R.NGQVCFSTQDHKPCNPVEKER.I1 7.101139 3.96 64.3 1 K.GPTEQLVSPEPEVYEIVR.A

19 4.986738 3.58 34.7 2 R.AEEDEFVVLACDGIWDVMSNEELCEFVK.S1 7.86254 3.86 50 1 L.ACDGIWDVMSNEELCEFVK.S1 5.781418 4.58 53.3 16 K.SRLEVSDDLENVCNWVVDTCLHK.G1 5.890745 4.25 80.8 2 R.LEVSDDLENVCNWVVDTCLHK.G1 7.327699 4.25 61.3 5 R.LEVSDDLENVCNWVVDTCLHK.G1 7.301586 6.56 87.5 1 R.DNMSVVLVCFSNAPK.V1 6.481793 4.89 94.4 2 R.DSELDKHLESR.V3 5.196372 4.89 75.9 3 R.DSELDKHLESR.V1 6.227369 4.71 59.6 1 R.DSELDKHLESRVEEIMQK.S1 8.558758 4.72 100 1 K.SGEEGMPDLAHVMR.I

15 5.007711 4.72 61.1 1 K.SGEEGMPDLAHVMR.I1 8.783405 4.25 64.5 2 R.LNPHKDNDGGAGDLEDSLVAL.-

17 5.266704 4.25 37.3 1 R.LNPHKDNDGGAGDLEDSLVAL.-Tax_Id=10090 Gene_Symbol=LOC100048062 similar to LOC665931 protein isoform 1

1 7.09218 4.46 94.1 1 K.NIEDVIAQGVGK.L1 8.061486 4.46 95 1 K.NIEDVIAQGVGK.L

37 4.413512 4.89 31.6 1 K.LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK.K1 8.301945 3.64 70.4 1 K.KEESEESDDDMGFGLFD.-1 7.977026 3.64 64 1 K.KEES(79.9663)EES(79.9663)DDDMGFGLFD.-

Tax_Id=10090 Gene_Symbol=Uqcrh Cytochrome b-c1 complex subunit 6, mitochondrial 2 5.451815 3.95 43.8 1 K.MLTGSGDPKEEEEEELVDPLTTVR.E1 5.400197 4.72 93.3 2 R.ERLELCDNR.V2 8.555782 4.12 50 3 R.SQTEEDCTEELFDFLHAR.D1 6.650831 4.12 52.7 2 R.SQTEEDCTEELFDFLHAR.D

Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-4 of Protein phosphatase 1B

5 8.02733 4.95 38 7 R.VEMEDAHTAVVGIPHGLDNWSFFAVYDGHAGSR.V1 8.248051 5.52 67.9 1 R.VANYCSTHLLEHITTNEDFR.A1 6.79956 5.52 61.5 1 R.VANYCSTHLLEHITTNEDFR.A8 4.228804 4.46 70 1 K.SGSALEPSVESVK.T9 6.038026 7.16 46.4 1 R.NGQVCFSTQDHKPCNPVEK.E



15 5.007711 4.72 61.1 1 K.SGEEGMPDLAHVMR.I1 6.821144 4.14 91.7 1 K.DNDGMADLSTSICKPS.-

Tax_Id=10090 Gene_Symbol=Ppm1b protein phosphatase 1B isoform 1 5 8.02733 4.95 38 7 R.VEMEDAHTAVVGIPHGLDNWSFFAVYDGHAGSR.V1 8.248051 5.52 67.9 1 R.VANYCSTHLLEHITTNEDFR.A1 6.79956 5.52 61.5 1 R.VANYCSTHLLEHITTNEDFR.A8 4.228804 4.46 70 1 K.SGSALEPSVESVK.T9 6.038026 7.16 46.4 1 R.NGQVCFSTQDHKPCNPVEK.E



15 5.007711 4.72 61.1 1 K.SGEEGMPDLAHVMR.I1 9.373054 4.42 78.8 2 R.LNPHKDNDGASDEAEEGGSQGK.L1 5.838097 4.42 49.2 2 R.LNPHKDNDGASDEAEEGGSQGK.L1 8.969216 3.8 67.6 1 K.VEGEESPADPAAAAASSNSDGGNPVAMQER.D1 6.442969 4.14 95.2 3 R.DTEGGPAGLDSR.N

Tax_Id=10090 Gene_Symbol=Ywhaq Isoform 1 of 14-3-3 protein theta Tax_Id=10090 Gene_Symbol=Ywhaq 34 kDa protein

1 4.956279 4.4 56 1 K.LAEQAERYDDMATCMK.A1 6.696171 3.96 100 20 K.AVTEQGAELSNEER.N1 5.938579 4.46 100 1 R.SICTTVLELLDK.Y3 4.437725 4.72 40.2 2 R.SICTTVLELLDKYLIANATNPESK.V

1 6.830123 4.14 100 1 R.YLAEVACGDDR.K1 7.530107 4.72 100 5 R.YLAEVACGDDRK.Q1 11.27122 4.72 93.3 1 R.KQTIENSQGAYQEAFDISK.K1 7.611524 6.56 51.9 1 R.KQTIENSQGAYQEAFDISKK.E1 8.112727 4.14 96.6 1 K.QTIENSQGAYQEAFDISK.K

12 7.307281 3.8 44.8 1 K.TAFDEAIAELDTLNEDSYK.D1 9.561481 4.03 44.7 4 K.TAFDEAIAELDTLNEDSYKDSTLIMQLLR.D1 7.588341 3.2 50 2 R.DNLTLWTSDSAGEECDAAEGAEN.-

Tax_Id=10090 Gene_Symbol=C1qbp complement component 1, q subcomponent binding protein 1 11.27028 4.53 90 1 A.LHTEGDKAFVEFLTDEIKEEK.K1 8.822924 4.53 59 1 A.LHTEGDKAFVEFLTDEIKEEK.K1 6.83186 4.25 95.5 1 K.AFVEFLTDEIKEEK.K1 7.724248 3.96 100 1 K.MSGDWELEVNGTEAK.L1 8.453341 3.86 67.7 2 K.AEEQEPELTSTPNFVVEVTK.T

12 6.250894 3.86 45.3 2 K.AEEQEPELTSTPNFVVEVTK.T1 9.652037 4.12 49.3 2 K.TLVLDCHYPEDEIGHEDEAESDIFSIK.E1 5.886182 4.14 95.2 1 K.EVSFQATGDSEWR.D1 9.237837 4.12 76.9 1 R.DTNYTLNTDSLDWALYDHLMDFLADR.G1 7.220202 4.12 41.8 1 R.DTNYTLNTDSLDWALYDHLMDFLADR.G1 4.889952 3.95 40.8 1 R.GVDNTFADELVELSTALEHQEYITFLEDLK.S

Tax_Id=10090 Gene_Symbol=Ppm1b;LOC100048520 Isoform Beta-5 of Protein phosphatase 1B Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-2 of Protein phosphatase 1B Tax_Id=10090 Gene_Symbol=Ppm1b Isoform Beta-3 of Protein phosphatase 1B

5 8.02733 4.95 38 7 R.VEMEDAHTAVVGIPHGLDNWSFFAVYDGHAGSR.V1 8.248051 5.52 67.9 1 R.VANYCSTHLLEHITTNEDFR.A1 6.79956 5.52 61.5 1 R.VANYCSTHLLEHITTNEDFR.A8 4.228804 4.46 70 1 K.SGSALEPSVESVK.T9 6.038026 7.16 46.4 1 R.NGQVCFSTQDHKPCNPVEK.E



15 5.007711 4.72 61.1 1 K.SGEEGMPDLAHVMR.ITax_Id=10090 Gene_Symbol=Ywhab Isoform Long of 14-3-3 protein beta/alpha Tax_Id=10090 Gene_Symbol=Ywhab Isoform Short of 14-3-3 protein beta/alpha

1 6.947441 4.4 84.6 1 K.LAEQAERYDDMAAAMK.A1 8.013042 4.4 76.2 1 K.LAEQAERYDDMAAAMK.A1 7.124858 4.4 78.3 3 K.AVTEQGHELSNEER.N1 5.389403 4.4 66.7 1 K.AVTEQGHELSNEER.N1 8.47825 4.03 92.9 4 R.EKIEAELQDICNDVLELLDK.Y

1 6.178942 4.03 64.3 4 R.EKIEAELQDICNDVLELLDK.Y2 10.36119 4.19 37.7 2 R.EKIEAELQDICNDVLELLDKYLILNATQAESK.V1 8.245224 3.8 67.9 4 K.IEAELQDICNDVLELLDK.Y1 8.214865 3.8 69.8 1 K.IEAELQDICNDVLELLDK.Y1 6.60913 4.03 41.1 1 K.IEAELQDICNDVLELLDKYLILNATQAESK.V1 6.526467 4.46 94.4 4 R.YLSEVASGENK.Q1 9.995761 3.8 78.6 3 K.TAFDEAIAELDTLNEESYK.D2 10.25111 4.03 38.7 3 K.TAFDEAIAELDTLNEESYKDSTLIMQLLR.D1 9.214927 3.2 80 2 R.DNLTLWTSENQGDEGDAGEGEN.-

Tax_Id=10090 Gene_Symbol=Eif4b Eukaryotic translation initiation factor 4B 1 9.499345 4.14 64.7 1 K.TISLTDFLAEDGGTGGGSTYVPK.P1 8.315454 3.89 38.7 2 K.PVSWADETDDLEGDVSTTWHSNDDDVYR.A1 5.486881 3.89 39.3 1 K.PVSWADETDDLEGDVSTTWHSNDDDVYR.A2 5.067122 6.56 44.8 3 R.SRLPKSPPY(79.9663)TAFLGNLPYDVTEDSIK.D

26 6.26611 6.56 38.2 1 R.SRLPKS(79.9663)PPYTAFLGNLPYDVTEDSIK.D1 7.511049 4.14 57.1 1 K.S(79.9663)PPYTAFLGNLPYDVTEDSIK.D1 7.255195 4.14 60.7 1 K.SPPYT(79.9663)AFLGNLPYDVTEDSIK.D1 8.057843 4.4 82.8 2 K.SPPYTAFLGNLPYDVTEDSIKDFFR.G1 7.505433 4.4 46.3 4 K.SPPYTAFLGNLPYDVTEDSIKDFFR.G1 5.810544 4.42 39.2 1 R.LKGFGYAEFEDLDSLLSALSLNEESLGNRR.I1 4.121635 4.42 40.8 1 R.LKGFGYAEFEDLDSLLSALSLNEESLGNRR.I1 8.285692 3.8 75.9 5 K.GFGYAEFEDLDSLLSALSLNEESLGNR.R1 8.802938 3.8 50.7 5 K.GFGYAEFEDLDSLLSALSLNEESLGNR.R1 7.443496 4.12 47.4 18 K.GFGYAEFEDLDSLLSALSLNEESLGNRR.I1 6.136581 4.73 75 6 R.IRVDVADQAQDKDRDDR.S1 6.092231 4.73 54.9 6 R.IRVDVADQAQDKDRDDR.S1 6.772887 4.73 56.9 4 R.IRVDVADQAQDKDRDDR.S1 6.174314 4.89 80 1 R.NRDSDKTDTDWR.A1 5.903282 4.4 78.6 1 R.DSDKTDTDWR.A1 6.199133 4.4 93.3 5 R.DSDKTDTDWR.A6 7.224785 4.4 74.1 5 R.DSDKTDTDWR.A1 6.180016 4.72 78.3 4 R.ARPTTDSFDDYPPR.R8 4.26761 4.72 62.2 1 R.ARPTTDSFDDYPPR.R4 5.112609 4.72 52.2 3 R.ARPTTDS(79.9663)FDDYPPR.R2 5.566534 4.72 59.1 1 R.ARPTT(79.9663)DSFDDYPPR.R1 6.778604 4.72 75 2 R.ARPT(79.9663)TDSFDDYPPR.R1 9.547663 4.72 93.1 1 R.SAPKEDDASASTSQSSR.A1 7.393411 10.06 65.5 1 R.SRTGS(79.9663)ESSQTGASATSGR.N2 6.297894 6.56 65.4 1 R.T(79.9663)GSESSQTGASATSGR.N1 5.83997 6.56 69.6 1 R.TGS(79.9663)ESSQTGASATSGR.N

60 6.015604 5.08 32.9 4 K.SLENETLNKEEDCHSPTSKPPKPDQPLK.V1 7.396366 4.46 68 4 R.SQSS(79.9663)DTEQPSPTSGGGK.V1 7.25887 4.46 77.8 4 R.SQSSDT(79.9663)EQPSPTSGGGK.V7 4.58586 4.89 34.9 1 R.SQSSDTEQPS(79.9663)PTSGGGKVAAVQPPEEGPSRK.D1 10.15612 6.56 75.8 1 K.DGNKVDVVGATQGQAGSCSR.G1 4.293166 5.8 100 1 R.DHWKDLDR.K1 8.365491 3.12 78.1 1 K.YAALSVDGEDEDEGDDCTE.-

Tax_Id=10090 Gene_Symbol=Wdr77 7 kDa protein

1 4.852655 10.88 57.7 1 -.MRKDT(79.9663)PPPLVPPAAR.E1 5.325102 4.46 82.6 3 R.EWNLPPNAPACMER.Q

Tax_Id=10090 Gene_Symbol=C1qbp Complement component 1 Q subcomponent-binding protein, mitochondrial 1 11.27028 4.53 90 1 A.LHTEGDKAFVEFLTDEIKEEK.K1 8.822924 4.53 59 1 A.LHTEGDKAFVEFLTDEIKEEK.K1 6.83186 4.25 95.5 1 K.AFVEFLTDEIKEEK.K1 7.724248 3.96 100 1 K.MSGDWELEVNGTEAK.L1 9.652037 4.12 49.3 2 K.TLVLDCHYPEDEIGHEDEAESDIFSIK.E1 5.886182 4.14 95.2 1 K.EVSFQATGDSEWR.D1 9.237837 4.12 76.9 1 R.DTNYTLNTDSLDWALYDHLMDFLADR.G1 7.220202 4.12 41.8 1 R.DTNYTLNTDSLDWALYDHLMDFLADR.G1 4.889952 3.95 40.8 1 R.GVDNTFADELVELSTALEHQEYITFLEDLK.S

Tax_Id=10090 Gene_Symbol=Ywhaq Isoform 2 of 14-3-3 protein theta 1 4.956279 4.4 56 1 K.LAEQAERYDDMATCMK.A1 6.696171 3.96 100 20 K.AVTEQGAELSNEER.N1 5.938579 4.46 100 1 R.SICTTVLELLDK.Y3 4.437725 4.72 40.2 2 R.SICTTVLELLDKYLIANATNPESK.V1 6.830123 4.14 100 1 R.YLAEVACGDDR.K1 7.530107 4.72 100 5 R.YLAEVACGDDRK.Q1 11.27122 4.72 93.3 1 R.KQTIENSQGAYQEAFDISK.K1 7.611524 6.56 51.9 1 R.KQTIENSQGAYQEAFDISKK.E1 8.112727 4.14 96.6 1 K.QTIENSQGAYQEAFDISK.K

12 7.307281 3.8 44.8 1 K.TAFDEAIAELDTLNEDSYK.D1 9.561481 4.03 44.7 4 K.TAFDEAIAELDTLNEDSYKDSTLIMQLLR.D

Tax_Id=10090 Gene_Symbol=Ywhae 15 kDa protein 1 7.395886 4.25 80 1 K.LAEQAERYDEMVESMK.K1 6.943728 4.25 68.3 1 K.LAEQAERYDEMVESMK.K1 7.031632 4.57 70.4 1 K.LAEQAERYDEMVESMKK.V1 5.970022 4.57 69.8 1 K.LAEQAERYDEMVESMKK.V

43 4.478447 4.57 48.6 1 K.LAEQAERYDEMVESMKK.V1 6.368708 4.14 93.3 1 R.YDEMVESMK.K1 5.758876 4.72 100 4 R.YDEMVESMKK.V1 5.63318 4.72 68.8 9 R.YDEMVESMKK.V1 7.478849 3.96 95 44 K.VAGMDVELTVEER.N1 6.428403 4.72 95 1 R.IISSIEQKEENK.G1 9.023167 4.57 75 2 R.IISSIEQKEENKGGEDK.L1 8.512102 5.02 86.2 1 R.IISSIEQKEENKGGEDKLK.M1 7.132406 4.14 100 1 K.LICCDILDVLDK.H

Tax_Id=10090 Gene_Symbol=Ybx1 Y box protein 1 1 9.767858 4.25 54.1 21 R.NYQQNYQNSESGEKNEGSESAPEGQAQQR.R1 7.891757 4.4 63.2 2 R.RPQYSNPPVQGEVMEGADNQGAGEQGR.P1 9.706851 3.95 69 2 R.EDGNEEDKENQGDETQGQQPPQR.R1 6.197321 3.95 50 7 R.EDGNEEDKENQGDETQGQQPPQR.R

46 4.676858 4.19 34.8 1 R.EDGNEEDKENQGDETQGQQPPQRR.Y1 6.659123 3.31 60.7 1 K.AADPPAENSSAPEAEQGGAE.-

Tax_Id=10090 Gene_Symbol=Ywhab Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 1 6.947441 4.4 84.6 1 K.LAEQAERYDDMAAAMK.A1 8.013042 4.4 76.2 1 K.LAEQAERYDDMAAAMK.A

1 7.124858 4.4 78.3 3 K.AVTEQGHELSNEER.N1 5.389403 4.4 66.7 1 K.AVTEQGHELSNEER.N1 8.47825 4.03 92.9 4 R.EKIEAELQDICNDVLELLDK.Y1 6.178942 4.03 64.3 4 R.EKIEAELQDICNDVLELLDK.Y2 10.36119 4.19 37.7 2 R.EKIEAELQDICNDVLELLDKYLILNATQAESK.V1 8.245224 3.8 67.9 4 K.IEAELQDICNDVLELLDK.Y1 8.214865 3.8 69.8 1 K.IEAELQDICNDVLELLDK.Y1 6.60913 4.03 41.1 1 K.IEAELQDICNDVLELLDKYLILNATQAESK.V1 6.526467 4.46 94.4 4 R.YLSEVASGENK.Q

Tax_Id=10090 Gene_Symbol=Wdr77 Methylosome protein 50 1 4.852655 10.88 57.7 1 -.MRKDT(79.9663)PPPLVPPAAR.E1 5.325102 4.46 82.6 3 R.EWNLPPNAPACMER.Q1 8.558673 3.86 74.2 4 K.DPSAAPNEGFCSAGVQTEAGVADLTWVGDK.G7 7.39196 3.86 34.6 3 K.DPSAAPNEGFCSAGVQTEAGVADLTWVGDK.G1 7.096197 3.8 64.3 29 K.GILVASDSGAVELWELDENETLIVSK.F5 7.196183 4.72 37.7 2 K.YEHDDIVSTVTVLSSGTQAVSGSK.D1 6.82765 4.14 89.5 2 K.DSVFLSCSEDSR.I

18 4.607856 4.4 34.6 1 R.LVFSPHSVPLLTSLSEDCSLAVLDSSLSEVFR.STax_Id=10090 Gene_Symbol=Ywhae Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

1 7.478849 3.96 95 44 K.VAGMDVELTVEER.N1 6.428403 4.72 95 1 R.IISSIEQKEENK.G1 9.023167 4.57 75 2 R.IISSIEQKEENKGGEDK.L1 8.512102 5.02 86.2 1 R.IISSIEQKEENKGGEDKLK.M1 7.132406 4.14 100 1 K.LICCDILDVLDK.H1 6.022575 4.89 52.4 1 K.LICCDILDVLDKHLIPAANTGESK.V1 5.278493 7.33 95 1 K.HLIPAANTGESK.V1 6.271328 4.46 93.3 1 R.YLAEFATGNDR.K1 7.038268 6.56 80 1 R.YLAEFATGNDRK.-

Tax_Id=10090 Gene_Symbol=LOC100047236 similar to 14-3-3 zeta 1 7.331036 4.4 76.9 1 K.LAEQAERYDDMAACMK.S1 7.081261 4.4 66.7 1 K.LAEQAERYDDMAACMK.S1 7.23296 3.96 100 2 K.SVTEQGAELSNEER.N1 6.325334 4.42 65.4 1 R.EKIETELRDICNDVLSLLEK.F1 6.113974 4.42 56.6 4 R.EKIETELRDICNDVLSLLEK.F1 6.049581 4.25 81.5 4 K.IETELRDICNDVLSLLEK.F1 7.177131 4.42 43.7 2 K.IETELRDICNDVLSLLEKFLIPNASQPESK.V1 4.501529 4.14 95 1 R.DICNDVLSLLEK.F1 5.081926 6.56 85 1 K.FLIPNASQPESK.V1 5.846799 4.72 100 2 R.YLAEVAAGDDKK.G1 6.328741 4.72 85 2 R.YLAEVAAGDDKK.G1 5.256918 4.42 41.6 1 R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.K1 4.280901 4.42 33.9 1 R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.K6 4.375668 4.73 36.3 1 R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISKK.E1 12.35918 4.72 96.6 1 K.KGIVDQSQQAYQEAFEISK.K1 5.009207 4.72 53.1 1 K.KGIVDQSQQAYQEAFEISK.K1 6.92062 4.14 82.2 1 K.GIVDQSQQAYQEAFEISK.K

Tax_Id=10090 Gene_Symbol=Gm2423 similar to Ywhaq protein 1 4.956279 4.4 56 1 K.LAEQAERYDDMATCMK.A

1 6.696171 3.96 100 20 K.AVTEQGAELSNEER.N1 5.938579 4.46 100 1 R.SICTTVLELLDK.Y3 4.437725 4.72 40.2 2 R.SICTTVLELLDKYLIANATNPESK.V1 11.27122 4.72 93.3 1 Q.KQTIENSQGAYQEAFDISK.K1 7.611524 6.56 51.9 1 Q.KQTIENSQGAYQEAFDISKK.E1 8.112727 4.14 96.6 1 K.QTIENSQGAYQEAFDISK.K

12 7.307281 3.8 44.8 1 K.TAFDEAIAELDTLNEDSYK.D1 9.561481 4.03 44.7 4 K.TAFDEAIAELDTLNEDSYKDSTLIMQLLR.D1 7.588341 3.2 50 2 R.DNLTLWTSDSAGEECDAAEGAEN.-

Tax_Id=10090 Gene_Symbol=Uqcrq Cytochrome b-c1 complex subunit 8 5 7.531303 6.56 39.4 2 R.ILRVAPPFVVVYLIYTWGNQEFEQSK.R2 4.527909 4.46 40 2 R.VAPPFVVVYLIYTWGNQEFEQSK.R1 5.229679 4.46 45.6 2 R.VAPPFVVVYLIYTWGNQEFEQSK.R1 6.37672 6.56 87.5 1 R.KNPAMYENDK.-

Tax_Id=10090 Gene_Symbol=Tpm3 8 kDa protein 1 7.133857 4.57 84 1 R.ALKDEEKMELQEIQLK.E1 4.320869 4.72 94.4 1 R.KLVIIEGDLER.T1 6.390039 4.57 79.2 1 R.KLVIIEGDLERTEER.A

Tax_Id=10090 Gene_Symbol=Krt18 Keratin, type I cytoskeletal 18 1 7.371392 10.88 79.4 2 R.VRPASSAAS(79.9663)VYAGAGGSGSR.I

46 4.453723 4.4 34.6 2 R.SVWGGSVGSAGLAGMGGIQTEKETMQDLNDR.L1 5.406134 4.14 93.3 2 K.ETMQDLNDR.L1 9.512419 4.25 85.7 2 R.LQLETEIEALKEELLFMK.K1 10.06928 4.12 100 5 K.NHEEEVQGLEAQIASSGLTVEVDAPK.S1 6.886105 4.12 45.9 2 K.NHEEEVQGLEAQIASSGLTVEVDAPK.S1 6.68704 4.12 49.3 2 R.TLQTLEIDLDSMKNQNINLENSLGDVEAR.Y1 7.338372 4.14 95.8 1 K.NQNINLENSLGDVEAR.Y

11 6.144021 4.72 46.7 1 K.AQMEQLNGVLLHLESELAQTR.A1 4.785714 4.72 58.5 1 K.AQMEQLNGVLLHLESELAQTR.A1 6.551979 4.46 100 1 R.QAQEYEALLNIK.V1 6.193955 4.12 73.3 1 R.RLLEDGEDFSLNDALDSSNSMQTVQK.T1 6.745881 4.12 44.1 1 R.RLLEDGEDFSLNDALDSSNSMQTVQK.T1 9.031349 3.8 56.7 3 R.LLEDGEDFSLNDALDSSNSMQTVQK.T

Tax_Id=10090 Gene_Symbol=Npm1 Nucleophosmin Tax_Id=10090 Gene_Symbol=LOC100046628 similar to Nucleophosmin Tax_Id=10090 Gene_Symbol=Npm1 Nucleophosmin 1 Tax_Id=10090 Gene_Symbol=Npm1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Npm1 Nucleophosmin 1

1 8.129019 5.06 61.4 6 K.ADKDYHFKVDNDENEHQLSLR.T3 6.032238 4.4 64.9 1 K.VDNDENEHQLSLR.T1 6.324744 4.58 50.7 1 R.TVSLGAGAKDELHIVEAEAMNYEGSPIK.V1 6.739462 4.25 93.5 1 K.DELHIVEAEAMNYEGSPIK.V1 6.412991 4.01 44.9 1 K.CGSGPVHISGQHLVAVEEDAES(79.9663)EDEDEEDVK.L1 6.028474 4.16 33.8 1 K.CGSGPVHISGQHLVAVEEDAES(79.9663)EDEDEEDVKLLGMSGK.R1 8.834982 3.53 41 1 K.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVK.K

48 7.354699 3.53 27 1 K.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVK.K10 5.33547 3.67 23.4 1 K.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.S

2 5.808253 3.67 28.8 1 K.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.S

1 6.151398 3.67 31.9 1 K.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.S27 3.784902 3.53 26.1 1 K.LDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.S

Tax_Id=10090 Gene_Symbol=Thrap3 Thrap3 protein 1 6.576977 4.16 44.3 1 K.WAHDKFS(79.9663)GEEGEIEDDES(79.9663)GTENREEK.D

Tax_Id=10090 Gene_Symbol=Ybx1 Nuclease-sensitive element-binding protein 1 Tax_Id=10090 Gene_Symbol=LOC100045189 similar to transcription factor EF1

1 9.728408 3.8 92.3 2 R.SVGDGETVEFDVVEGEK.G32 7.038097 4.03 32.2 1 R.SVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSK.Y

1 9.767858 4.25 54.1 21 R.NYQQNYQNSESGEKNEGSESAPEGQAQQR.R1 7.891757 4.4 63.2 2 R.RPQYSNPPVQGEVMEGADNQGAGEQGR.P1 9.706851 3.95 69 2 R.EDGNEEDKENQGDETQGQQPPQR.R1 6.197321 3.95 50 7 R.EDGNEEDKENQGDETQGQQPPQR.R

46 4.676858 4.19 34.8 1 R.EDGNEEDKENQGDETQGQQPPQRR.Y1 6.659123 3.31 60.7 1 K.AADPPAENSSAPEAEQGGAE.-

Tax_Id=10090 Gene_Symbol=Cox6b1 Cytochrome c oxidase subunit 6B1 1 4.970512 7.11 80.6 1 K.NCWQNYLDFHR.C1 5.816269 4.46 88.2 1 K.GGDVSVCEWYR.R1 8.829452 4.46 100 1 K.SLCPVSWVSAWDDR.I

Tax_Id=10090 Gene_Symbol=Rps3a 40S ribosomal protein S3a Tax_Id=10090 Gene_Symbol=Gm10119 similar to ribosomal protein S3a

4 3.973941 4.46 100 1 K.DWYDVK.A1 8.781582 3.96 85.7 2 R.VFEVSLADLQNDEVAFR.K1 5.188406 4.46 100 3 K.LITEDVQGK.N1 4.990646 7.11 100 1 K.NCLTNFHGMDLTR.D1 6.766509 4.73 44.1 1 R.EVQTNDLKEVVNKLIPDSIGKDIEK.A1 6.675318 5.63 95.5 1 K.LMELHGEGGSSGK.A1 8.861472 4.12 83.3 1 K.AAGDETGAKVERADGYEPPVQESV.-1 6.61793 3.47 89.5 1 R.ADGYEPPVQESV.-

Tax_Id=10090 Gene_Symbol=Rps15 40S ribosomal protein S15 Tax_Id=10090 Gene_Symbol=Rps15 Putative uncharacterized protein

9 6.069873 4.4 37.3 1 K.FTYRGVDLDQLLDMSYEQLMQLYSAR.Q1 10.08958 3.34 81.5 1 R.GVDLDQLLDMSYEQLMQLY.S1 8.937484 3.96 80.8 4 R.GVDLDQLLDMSYEQLMQLYSAR.Q1 7.477458 3.96 47.5 4 R.GVDLDQLLDMSYEQLMQLYSAR.Q1 6.574386 6.56 70.3 1 K.KEAPPMEKPEVVK.T1 5.394371 4.72 75 1 K.EAPPMEKPEVVK.T1 8.156544 4.46 68.8 3 R.DMIILPEMVGSMVGVYNGK.T

Tax_Id=10090 Gene_Symbol=Kctd5 BTB/POZ domain-containing protein KCTD5 1 10.23841 4.03 76.7 1 R.LCQADPDLDSDKDETGAYLIDR.D1 6.444823 4.03 55.9 1 R.LCQADPDLDSDKDETGAYLIDR.D

11 5.250854 4.19 26.2 1 R.LCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLR.H2 6.799478 4.19 22.2 1 R.LCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLR.H1 10.99636 3.8 72.4 13 K.DLAEEGVLEEAEFYNITSLIK.L1 9.73933 3.96 82.1 1 R.VLQCQEEELTQMVSTMSDGWK.F1 8.123525 4.72 81.5 5 K.ELHNTPYGTTSEPSEK.A

Tax_Id=10090 Gene_Symbol=Pgrmc1 Membrane-associated progesterone receptor component 1 1 5.68352 4.12 60.6 1 K.IVRGDQPGASGDNDDDEPPPLPR.L1 10.81553 3.8 87.5 9 R.GDQPGASGDNDDDEPPPLPR.L

1 8.592862 3.89 42.1 2 K.EALKDEYDDLSDLTPAQQETLSDWDSQFTFK.Y2 4.953265 4.12 46.7 2 K.LLKEGEEPTVYS(79.9663)DDEEPKDETAR.K1 5.87171 3.89 63 5 K.EGEEPTVYS(79.9663)DDEEPKDETAR.K

Tax_Id=10090 Gene_Symbol=Myl12b Myosin regulatory light chain 12B 1 5.965439 4.46 86.7 1 K.EAFNMIDQNR.D1 5.907545 4.58 64.6 1 R.DGFIDKEDLHDMLASLGK.N1 10.05995 3.86 92.9 1 R.NAFACFDEEATGTIQEDYLR.E1 4.332873 4.03 71.4 1 R.ELLTTMGDRFTDEEVDELYR.E1 5.725149 4.03 52.8 1 R.ELLTTMGDRFTDEEVDELYR.E1 6.686996 3.86 100 1 R.FTDEEVDELYR.E

Tax_Id=10090 Gene_Symbol=Tmod3 Tropomodulin-3 1 9.121609 4.28 88.5 1 R.KDLGDYKDLDEDELLGK.L1 5.563428 4.03 63.8 1 K.DLGDYKDLDEDELLGK.L1 8.774592 4.12 96.4 1 K.DLGDYKDLDEDELLGKLSESELK.Q1 4.365957 4.12 50.8 1 K.DLGDYKDLDEDELLGKLS(79.9663)ESELK.Q1 8.182488 3.86 68.8 1 K.QLETVLDDLDPENALLPAGFR.Q1 7.045827 5 72 1 K.QALEHKDRDDYVPYTGEK.K1 6.948189 4.4 90 2 K.DRDDYVPYTGEK.K1 7.849412 3.96 72.4 2 K.ILPVFDEPPNPTNVEESLK.R1 7.260891 4.4 75.9 1 K.ILPVFDEPPNPTNVEESLKR.I1 5.471331 6.56 100 1 R.LVEVNLNNIK.N1 7.217753 4.46 95.5 2 R.SNDPVAVAFADMLK.V

30 5.691817 4.25 33.3 4 K.SLNMESNFITGAGVLALIDALRDNETLMELK.I1 7.207995 4.25 38.5 1 K.SLNMESNFITGAGVLALIDALRDNETLMELK.I1 4.824549 4.14 100 1 R.DNETLMELK.I

Tax_Id=10090 Gene_Symbol=Myh9 Myh9 protein (Fragment) 1 6.436563 4.14 100 1 R.LTEMETMQSQLMAEK.L

15 7.296098 3.8 44.8 1 K.LQLQEQLQAETELCAEAEELR.A1 7.212151 4.58 100 2 K.KQELEEICHDLEAR.V1 8.846653 4.03 88.9 2 K.KMQQNIQELEEQLEEEESAR.Q1 5.995075 4.03 63.5 1 K.KMQQNIQELEEQLEEEESAR.Q1 5.629617 3.69 61.2 1 K.MQQNIQELEEQLEEEESAR.Q1 9.035634 4.25 100 4 K.KLEEDQIIMEDQNCK.L1 5.231796 4.25 73.7 1 K.KLEEDQIIMEDQNCK.L1 7.116184 3.86 100 2 K.LEEDQIIMEDQNCK.L

Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 5 Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 4

1 7.283032 4.53 64.8 1 K.LKGTEDELDKYSEALKDAQEK.L1 6.9531 4.25 86.4 1 K.GTEDELDKYSEALK.D1 8.733254 4.28 74.1 1 K.GTEDELDKYSEALKDAQEK.L1 6.720276 4.31 53.7 1 K.GTEDELDKYSEALKDAQEKLELAEK.K1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G1 5.0176 4.57 65.9 1 R.AQKDEEKMEIQEIQLK.E1 5.05925 4.72 100 1 R.KLVIIESDLER.A

1 5.572603 4.57 70.8 1 R.KLVIIESDLERAEER.A1 6.015606 4.57 55.3 2 R.KLVIIESDLERAEER.A1 5.056613 4.25 90.9 1 K.LVIIESDLERAEER.A1 8.198394 4.53 76.9 2 K.ALMAAEDKYSQKEDKYEEEIK.V1 6.153659 4.53 64.8 1 K.ALMAAEDKYSQKEDKYEEEIK.V

Tax_Id=10090 Gene_Symbol=Rps15 Putative uncharacterized protein 1 4.449079 3.96 51.9 1 R.GVELDQLLDMSYEQLMQLYSAR.Q1 6.574386 6.56 70.3 1 K.KEAPPMEKPEVVK.T1 5.394371 4.72 75 1 K.EAPPMEKPEVVK.T1 8.156544 4.46 68.8 3 R.DMIILPEMVGSMVGVYNGK.T

Tax_Id=10090 Gene_Symbol=Gm9000 similar to ribosomal protein S3a 4 3.973941 4.46 100 1 K.DWYDVK.A1 8.781582 3.96 85.7 2 R.VFEVSLADLQNDEVAFR.K1 4.990646 7.11 100 1 K.NCLTNFHGMDLTR.D1 6.766509 4.73 44.1 1 R.EVQTNDLKEVVNKLIPDSIGKDIEK.A1 6.675318 5.63 95.5 1 K.LMELHGEGGSSGK.A1 8.861472 4.12 83.3 1 K.AAGDETGAKVERADGYEPPVQESV.-1 6.61793 3.47 89.5 1 R.ADGYEPPVQESV.-

1 5.430769 5.63 100 1 K.SLHTLFGDELCK.V1 6.179259 5.63 80 1 K.SLHTLFGDELCK.V1 8.897265 3.96 84.2 15 R.ETYGDMADCCEK.Q1 4.61673 4.71 76.9 2 K.QEPERNECFLSHKDDSPDLPK.L1 6.230965 4.71 52.7 2 K.QEPERNECFLSHKDDSPDLPK.L1 6.758543 4.89 91.7 1 R.NECFLSHKDDSPDLPK.L1 4.832688 4.89 62.2 1 R.NECFLSHKDDSPDLPK.L1 8.253316 4.57 67.9 2 K.LKPDPNTLCDEFKADEK.K2 8.231781 5.06 57.4 2 K.VHKECCHGDLLECADDRADLAK.Y1 6.605121 4.25 82.6 5 K.ECCHGDLLECADDR.A1 9.331416 4.42 89.3 3 K.ECCHGDLLECADDRADLAK.Y1 6.056703 4.42 60.4 4 K.ECCHGDLLECADDRADLAK.Y1 5.797319 4.46 100 1 K.YICDNQDTISSK.L1 6.33786 4.42 45.6 2 K.SHCIAEVEKDAIPENLPPLTADFAEDKDVCK.N1 6.113894 3.86 53.6 1 K.DAIPENLPPLTADFAEDK.D1 7.929518 4.12 83.3 2 K.DAIPENLPPLTADFAEDKDVCK.N1 7.859479 4.46 95 12 K.DAFLGSFLYEYSR.R1 7.345079 4.72 95 2 K.DDPHACYSTVFDK.L2 6.061158 4.72 67.6 1 K.DDPHACYSTVFDK.L1 6.89079 9.08 70.8 1 R.KVPQVSTPTLVEVSR.S1 7.804142 4.46 95.7 1 R.MPCTEDYLSLILNR.L1 8.005436 5.69 93.3 2 K.CCTESLVNR.R1 7.252453 6.56 72 1 R.RPCFSALTPDETYVPK.A1 9.178576 4.4 92.9 2 K.CCAADDKEACFAVEGPK.L1 9.745302 4.4 70.5 1 K.CCAADDKEACFAVEGPK.L

Tax_Id=10090 Gene_Symbol=Actb Actin, cytoplasmic 1 Tax_Id=10090 Gene_Symbol=Actg1 Actin, cytoplasmic 2

1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G

1 9.181855 4.72 70.4 1 R.VAPEEHPVLLTEAPLNPK.A1 6.957728 5.52 46.1 1 R.TTGIVMDSGDGVTHTVPIYEGYALPHAILR.L1 9.645959 6.56 100 1 R.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.S1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.S1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.S1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F1 7.745204 4.72 86.4 1 K.QEYDESGPSIVHR.K1 5.562833 4.72 75 1 K.QEYDESGPSIVHR.K

no description1 7.4853 9.08 90.9 1 R.FSSSSGYGGGSSR.V1 9.068069 4.25 90 2 R.LASYLDKVQALEEANNDLENK.I1 6.008748 4.25 58.9 1 R.LASYLDKVQALEEANNDLENK.I1 7.432235 4.28 46.4 2 R.LASYLDKVQALEEANNDLENKIQDWYDK.K1 7.224262 3.96 100 1 K.VQALEEANNDLENK.I1 4.857014 4.12 55.4 2 K.VQALEEANNDLENKIQDWYDK.K1 6.832084 4.4 59.3 2 K.NYSPYYNTIDDLKDQIVDLTVGNNK.T1 6.03729 4.4 37.7 1 K.NYSPYYNTIDDLKDQIVDLTVGNNK.T3 6.402772 4.42 34.6 2 K.NYSPYYNTIDDLKDQIVDLTVGNNKTLLDIDNTR.M1 6.052502 4.46 100 1 K.DQIVDLTVGNNK.T1 4.674853 4.46 100 1 K.TLLDIDNTR.M1 8.421865 4.25 92.3 2 K.SDLEMQYETLQEELMALKK.N1 4.871149 4.72 69.4 1 K.TLNDMRQEYEQLIAK.N

11 6.078323 4.8 32.1 1 K.NRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLR.H1 9.014711 4.42 44.7 2 R.KDIENQYETQITQIEHEVSSSGQEVQSSAK.E1 7.744086 4.12 47.9 5 K.DIENQYETQITQIEHEVSSSGQEVQSSAK.E1 8.715234 4.72 100 2 R.HGVQELEIELQSQLSK.K1 4.775445 4.72 60.4 2 R.HGVQELEIELQSQLSK.K1 8.200525 4.14 85.2 1 R.QEIECQNQEYSLLLSIK.M1 8.614721 4.12 88.9 1 K.EIETYHNLLEGGQEDFESSGAGK.I1 6.631883 4.12 66.7 2 K.EIETYHNLLEGGQEDFESSGAGK.I1 10.78017 8.8 60.5 1 R.GGSGGSYGGGGSGGGYGGGSGSR.G

Tax_Id=10090 Gene_Symbol=Actg1 Actin, gamma, cytoplasmic 1 1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 6.957728 5.52 46.1 1 R.TTGIVMDSGDGVTHTVPIYEGYALPHAILR.L1 9.645959 6.56 100 1 R.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.S1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.S1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.S1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F1 7.745204 4.72 86.4 1 K.QEYDESGPSIVHR.K1 5.562833 4.72 75 1 K.QEYDESGPSIVHR.K

Tax_Id=10090 Gene_Symbol=Rps17 40S ribosomal protein S17 Tax_Id=10090 Gene_Symbol=Gm12034 similar to ribosomal protein S17

Tax_Id=10090 Gene_Symbol=Gm12034 similar to ribosomal protein S17 1 7.018859 4.03 86.7 1 R.RDNYVPEVSALDQEIIEVDPDTK.E2 4.919096 4.03 42.6 1 R.RDNYVPEVSALDQEIIEVDPDTK.E1 7.370113 4.19 46.4 2 R.RDNYVPEVSALDQEIIEVDPDTKEMLK.L1 8.972152 3.69 56.7 2 R.DNYVPEVSALDQEIIEVDPDTK.E1 6.588347 3.69 50.8 1 R.DNYVPEVSALDQEIIEVDPDTK.E1 5.497717 3.95 77.8 1 R.DNYVPEVSALDQEIIEVDPDTKEMLK.L1 6.273638 6.56 66.7 2 K.LLDFGS(79.9663)LSNLQVTQPTVGMNFK.T

no description1 9.229805 10.06 90 1 K.GSLGGGFSSGGFSGGSFSR.G1 5.56328 6.56 100 2 K.VTMQNLNDR.L1 7.984779 3.96 100 1 R.ALEESNYELEGK.I1 7.269004 4.4 40.3 3 K.TIDDLKNQILNLTTDNANILLQIDNAR.L1 9.375885 4.46 93.1 3 K.NQILNLTTDNANILLQIDNAR.L1 5.515029 6.56 87.5 1 R.LKYENEVALR.Q1 8.131896 3.86 57.4 1 K.ADLEMQIESLTEELAYLK.K1 7.490369 4.14 74.2 2 R.NVSTGDVNVEMNAAPGVDLTQLLNNMR.S1 7.801102 4.14 43.7 1 R.NVSTGDVNVEMNAAPGVDLTQLLNNMR.S1 5.688808 6.56 84.2 1 R.SQYEQLAEQNRK.D9 4.823943 6.56 61.8 1 R.SQYEQLAEQNRK.D1 8.110954 4.57 58.9 4 R.SQYEQLAEQNRKDAEAWFNEK.S1 5.402465 4.72 100 1 R.KDAEAWFNEK.S1 9.083897 4.4 64.3 3 K.SKELTTEIDNNIEQISSYK.S2 4.686966 4.4 55.1 2 K.SKELTTEIDNNIEQISSYK.S1 8.493039 3.96 75 1 K.ELTTEIDNNIEQISSYK.S1 5.541385 3.96 58.3 1 K.ELTTEIDNNIEQISSYK.S3 4.976624 4.42 39.1 1 K.ELTTEIDNNIEQISSYKSEITELRR.N1 8.320866 4.14 81.8 3 K.QSLEASLAETEGR.Y1 7.105917 3.96 92.3 1 R.AETECQNTEYQQLLDIK.I2 6.935112 4.46 70.8 4 R.SLLEGEGSSGGGGR.G

Tax_Id=10090 Gene_Symbol=Stk38 Serine/threonine-protein kinase 38 2 6.371 4.72 61.5 1 K.VTLENFYSNLIAQHEER.E1 5.15934 4.42 73.7 1 K.VMEEEGLKDEEKR.L1 8.585593 4.7 44.2 2 K.KDTLTEEETQFYIAETVLAIDSIHQLGFIHR.D1 5.989231 4.72 78.9 1 R.DIKPDNLLLDSK.G

40 4.429483 6.56 35.3 1 R.RQLAFST(79.9663)VGTPDYIAPEVFMQTGYNK.L1 5.744678 4.46 45.6 1 R.QLAFST(79.9663)VGTPDYIAPEVFMQTGYNK.L1 7.471696 4.58 50.8 2 R.IGAPGVEEIKNNLFFEGVDWEHIR.E1 7.507303 4.72 95.5 2 K.NNLFFEGVDWEHIR.E2 7.744228 4.2 33.8 1 K.SIDDTSNFDEFPESDILKPTVTTSSHPETDYK.N2 5.840231 9.53 70.6 1 K.NKDWVFINYT(79.9663)YKR.F

Tax_Id=10090 Gene_Symbol=Calm1;Calm3;Calm2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Calm1;Calm3;Calm2 Calmodulin

1 6.48735 4.4 74.1 1 K.EAFSLFDKDGDGTITTK.E1 4.308271 4.73 60.5 1 R.KMKDTDSEEEIREAFR.V1 7.513344 4.72 92.3 1 R.VFDKDGNGYISAAELR.H1 9.789548 3.8 71.4 2 R.EADIDGDGQVNYEEFVQMMTAK.-1 7.955769 3.8 56.9 2 R.EADIDGDGQVNYEEFVQMMTAK.-

Tax_Id=10090 Gene_Symbol=Rbbp7 Retinoblastoma binding protein 7 11 4.096867 4.28 37 1 K.IGEEQSAEDAEDGPPELLFIHGGHTAK.I

Tax_Id=10090 Gene_Symbol=Eif2s2 Eukaryotic translation initiation factor 2 subunit 2 1 6.776653 4.28 61.4 1 K.KKPFMLDEEGDAQTEETQPSETK.E1 6.531729 4.57 89.3 1 R.KKDASDDLDDLNFFNQK.K1 7.647456 4.57 77.8 1 R.KKDASDDLDDLNFFNQK.K1 8.108947 3.86 91.7 1 K.DASDDLDDLNFFNQK.K1 7.510388 4.42 84.6 1 K.KIFDIDEAEEAIKDVK.I1 6.561015 4.42 68.8 1 K.KIFDIDEAEEAIKDVK.I1 6.394126 4.12 96 1 K.IFDIDEAEEAIKDVK.I1 4.327377 4.12 62.2 1 K.IFDIDEAEEAIKDVK.I1 6.198019 3.64 67.7 1 K.IESDAQEPAEPEDDLDIMLGNK.K

18 5.318 3.64 42.4 2 K.IESDAQEPAEPEDDLDIMLGNK.K3 6.399762 4.02 30.2 1 K.FPEEDEILEKDEALEDEDSKKDDGISFSSQTAWAGSER.D

Tax_Id=10090 Gene_Symbol=Gcdh 8 kDa protein 1 7.005584 4.42 59.3 8 K.SSRPVFDWKDPLILEEQLTADEK.L1 7.554172 3.86 91.3 1 K.DPLILEEQLTADEK.L

Tax_Id=10090 Gene_Symbol=Rps7 40S ribosomal protein S7 4 6.609117 4.28 37.7 3 K.IVKPNGEKPDEFESGISQALLELEMNSDLK.A

19 4.868488 4.28 34.1 1 K.IVKPNGEKPDEFESGISQALLELEMNSDLK.A1 10.90664 4.4 83.3 2 R.TLTAVHDAILEDLVFPSEIVGK.R1 4.601679 4.14 75 1 K.LTGKDVNFEFPEFQL.-

Tax_Id=10090 Gene_Symbol=Krt8 Keratin, type II cytoskeletal 8 1 7.547417 4.46 83.3 1 R.SNMDNMFESYINNLR.R1 9.959548 4.4 96.7 1 K.LKLEAELGNMQGLVEDFK.N1 6.602979 4.4 51 2 K.LKLEAELGNMQGLVEDFK.N1 6.185527 4.81 47.9 4 K.LKLEAELGNMQGLVEDFKNKYEDEINKR.T7 6.096478 4.81 34.5 1 K.LKLEAELGNMQGLVEDFKNKYEDEINKR.T8 5.16601 3.96 54.2 1 K.LEAELGNMQGLVEDFK.N1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T1 7.843509 4.14 94.4 1 R.TEMENEFVLIK.K1 5.245513 4.72 94.7 1 R.TEMENEFVLIKK.D1 6.799948 4.57 70.7 1 K.KDVDEAYMNKVELESR.L1 7.326807 4.14 100 6 K.DVDEAYMNK.V1 7.083211 4.14 92.9 7 K.DVDEAYMNK.V1 7.682394 4.25 91.7 1 K.DVDEAYMNKVELESR.L1 7.32119 4.14 100 1 R.LEGLTDEINFLR.Q1 8.335616 4.14 74.2 1 R.ELQSQISDTSVVLSMDNSR.S1 6.99816 4.14 100 1 R.SLDMDGIIAEVR.A2 5.766051 4.46 83.3 1 R.AQYEDIANR.S1 8.004234 4.14 100 1 R.ASLEAAIADAEQR.G1 8.604732 4.57 63.5 2 R.ASLEAAIADAEQRGEMAIKDAQTK.L

20 5.392532 4.53 30.7 1 R.ASLEAAIADAEQRGEMAIKDAQTKLAELEAALQR.A2 6.595163 4.46 77.8 1 K.LVSESSDVVSK.-

Tax_Id=10090 Gene_Symbol=Actb Putative uncharacterized protein 1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G1 9.181855 4.72 70.4 1 R.VAPEEHPVLLTEAPLNPK.A

1 6.957728 5.52 46.1 1 R.TTGIVMDSGDGVTHTVPIYEGYALPHAILR.L1 9.645959 6.56 100 1 R.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.S1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.S1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.S1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F1 7.745204 4.72 86.4 1 K.QEYDESGPSIVHR.K1 5.562833 4.72 75 1 K.QEYDESGPSIVHR.K

Tax_Id=10090 Gene_Symbol=Actg1 Putative uncharacterized protein 1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 9.181855 4.72 70.4 1 R.VAPEEHPVLLTEAPLNPK.A1 6.957728 5.52 46.1 1 R.TTGIVMDSGDGVTHTVPIYEGYALPHAILR.L1 9.645959 6.56 100 1 R.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.S1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.S1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.S1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F1 7.745204 4.72 86.4 1 K.QEYDESGPSIVHR.K1 5.562833 4.72 75 1 K.QEYDESGPSIVHR.K

Tax_Id=10090 Gene_Symbol=Actb Beta-actin (Fragment) 1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G1 9.181855 4.72 70.4 1 R.VAPEEHPVLLTEAPLNPK.A

Tax_Id=10090 Gene_Symbol=Rplp0 60S acidic ribosomal protein P0 1 5.409174 4.4 81.8 1 K.EDLTEIRDMLLANK.V1 5.541959 4.46 71 1 R.AGAIAPCEVTVPAQNTGLGPEK.T1 7.536709 4.4 47.4 1 F.SFGLIIQQVFDNGSIYNPEVLDITEQALHSR.F1 8.844186 4.14 70.4 1 R.VLALSVETEYTFPLTEK.V1 8.19238 3.58 85.2 4 K.AEAKEESEESDEDMGFGLFD.-1 7.182205 3.58 69.2 3 K.AEAKEES(79.9663)EES(79.9663)DEDMGFGLFD.-

Tax_Id=10090 Gene_Symbol=H2afz Histone H2A.Z Tax_Id=10090 Gene_Symbol=H2afv Histone H2A.V Tax_Id=10090 Gene_Symbol=H2afv 14 kDa protein

1 9.416384 4.14 50.7 1 R.VGATAAVYSAAILEYLTAEVLELAGNASK.D1 8.021659 4.4 54.7 2 R.VGATAAVYSAAILEYLTAEVLELAGNASKDLK.V1 5.80589 3.96 100 1 R.GDEELDSLIK.A

Tax_Id=10090 Gene_Symbol=Rpa3 Replication protein A 14 kDa subunit 1 7.45835 3.8 86.7 2 K.NGTIELMEPLDEEISGIVEVVGK.V1 6.781126 4.25 80 2 K.EDTNRFDLELYNEAVK.I

Tax_Id=10090 Gene_Symbol=Eif4a2 11 kDa protein Tax_Id=10090 Gene_Symbol=Eif4a2 11 kDa protein

13 7.668766 3.89 34.7 1 R.EHGGPEGMDPDGVIESNWNEIVDNFDDMNLK.ETax_Id=10090 Gene_Symbol=Hnrnpk Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=- 48 kDa protein

1 8.726964 4.25 95.5 1 K.RPAEDMEEEQAFK.R1 7.049439 4.57 79.2 1 K.RPAEDMEEEQAFKR.S1 5.027413 4.57 78.9 2 K.RPAEDMEEEQAFKR.S1 7.901464 4.14 82.1 1 R.TDYNASVSVPDSSGPER.Y

Tax_Id=10090 Gene_Symbol=Hist2h3c1;Hist1h3e;Hist1h3f;Hist2h3c2;Hist2h3b;Hist1h3b;Hist1h3d;Hist1h3c Histone H3.2 Tax_Id=10090 Gene_Symbol=Hist2h3c1;Hist1h3e;Hist1h3f;Hist2h3c2;Hist2h3b;Hist1h3b;Hist1h3d;Hist1h3c histone cluster 2, H3c1

1 5.618752 4.72 94.4 1 R.EIAQDFKTDLR.F1 10.11168 4.4 43.9 3 R.FQSSAVMALQEASEAYLVGLFEDTNLCAIHAK.R1 4.926746 4.4 37.7 1 R.FQSSAVMALQEASEAYLVGLFEDTNLCAIHAK.R

Tax_Id=10090 Gene_Symbol=Gm6421 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=- 13 kDa protein Tax_Id=10090 Gene_Symbol=LOC100045490;H3f3a;H3f3b Histone H3.3 Tax_Id=10090 Gene_Symbol=- hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Gm10257 hypothetical protein isoform 1

1 5.618752 4.72 94.4 1 R.EIAQDFKTDLR.F1 7.533685 4.4 43 2 R.FQSAAIGALQEASEAYLVGLFEDTNLCAIHAK.R

Tax_Id=10090 Gene_Symbol=Fabp1 Fatty acid-binding protein, liver 1 8.933097 3.8 86.2 1 R.NEFTLGEECELETMTGEK.V1 8.766109 4.14 56.2 1 K.SVTELNGDTITNTMTLGDIVYK.R

Tax_Id=10090 Gene_Symbol=Glul 12 kDa protein 20 5.097786 4.12 31.3 1 K.CVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFR.D

Tax_Id=10090 Gene_Symbol=Tpm3 Isoform 2 of Tropomyosin alpha-3 chain Tax_Id=10090 Gene_Symbol=Tpm3 29 kDa protein Tax_Id=10090 Gene_Symbol=Tpm3 29 kDa protein Tax_Id=10090 Gene_Symbol=- 29 kDa protein Tax_Id=10090 Gene_Symbol=Tpm3 Putative uncharacterized protein

1 8.241442 4.4 96 1 R.KIQVLQQQADDAEER.A1 6.831407 4.57 50 2 R.KIQVLQQQADDAEERAER.L1 8.297587 3.96 100 1 K.IQVLQQQADDAEER.A1 6.444202 4.25 66.7 1 K.IQVLQQQADDAEERAER.L1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G1 7.133857 4.57 84 1 R.ALKDEEKMELQEIQLK.E1 4.320869 4.72 94.4 1 R.KLVIIEGDLER.T1 6.390039 4.57 79.2 1 R.KLVIIEGDLERTEER.A

Tax_Id=10090 Gene_Symbol=LOC633387 similar to Npm1 protein 1 8.129019 5.06 61.4 6 K.ADKDYHFKVDNDENEHQLSLR.T3 6.032238 4.4 64.9 1 K.VDNDENEHQLSLR.T1 6.324744 4.58 50.7 1 R.TVSLGAGAKDELHIVEAEAMNYEGSPIK.V1 6.739462 4.25 93.5 1 K.DELHIVEAEAMNYEGSPIK.V

Tax_Id=10090 Gene_Symbol=Hist2h2ab;Hist2h2ac Histone H2A type 2-C Tax_Id=10090 Gene_Symbol=Hist2h2aa1;Hist2h2aa2 Histone H2A type 2-A

1 9.073675 4.14 75.9 1 R.VGAGAPVYMAAVLEYLTAEILELAGNAAR.D1 8.985741 4.14 49.3 2 R.VGAGAPVYMAAVLEYLTAEILELAGNAAR.D1 4.858065 4.72 100 1 R.NDEELNKLLGK.V

Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc;Gm6111 ribosomal protein S27a 1 7.702595 3.96 88 1 K.TITLEVEPSDTIENVK.A1 9.692141 4.4 83.9 1 R.ECPSDECGAGVFMGSHFDR.H1 7.952041 4.72 67.9 1 C.PSDECGAGVFMGSHFDR.H1 4.29579 4.72 59.1 1 C.PSDECGAGVFMGSHFDR.H1 8.652838 6.23 81.8 1 K.CCLTYCFNKPEDK.-1 5.875928 6.23 70.6 1 K.CCLTYCFNKPEDK.-

Tax_Id=10090 Gene_Symbol=- 11 kDa protein Tax_Id=10090 Gene_Symbol=- 11 kDa protein Tax_Id=10090 Gene_Symbol=- 11 kDa protein Tax_Id=10090 Gene_Symbol=- 12 kDa protein Tax_Id=10090 Gene_Symbol=- 12 kDa protein Tax_Id=10090 Gene_Symbol=- 12 kDa protein Tax_Id=10090 Gene_Symbol=LOC674678 similar to histone H4 Tax_Id=10090 Gene_Symbol=- 11 kDa protein Tax_Id=10090 Gene_Symbol=- 11 kDa protein Tax_Id=10090 Gene_Symbol=Hist1h4c;Hist1h4m;Hist1h4j;Hist1h4i;Gm11275;Hist1h4a;Hist1h4f;Hist2h4;Hist1h4h;Hist4h4;Hist1h4k;4930558J22Rik;Hist1h4d;Hist1h4b Histone H4

1 6.017026 9.08 94.7 1 R.DNIQGITKPAIR.R1 5.813885 4.46 88.2 1 R.ISGLIYEETR.G1 5.868694 5.63 100 1 R.DAVTYTEHAK.R

Tax_Id=10090 Gene_Symbol=Tpm1 Tpm1 protein 1 5.0176 4.57 65.9 1 R.AQKDEEKMEIQEIQLK.E

Tax_Id=10090 Gene_Symbol=Atp5j;LOC674583 ATP synthase-coupling factor 6, mitochondrial 1 7.600949 3.96 60 1 R.QASGGPVDIGPEYQQDLDR.E1 5.777503 4.4 84.2 1 K.FDDPKFEVIDKPQS.-1 4.954681 4.4 70.3 1 K.FDDPKFEVIDKPQS.-

Tax_Id=10090 Gene_Symbol=Tpm1 Isoform 1 of Tropomyosin alpha-1 chain Tax_Id=10090 Gene_Symbol=Tpm1 37 kDa protein Tax_Id=10090 Gene_Symbol=Tpm1 33 kDa protein Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 9 Tax_Id=10090 Gene_Symbol=Tpm1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Tpm1 Isoform 2 of Tropomyosin alpha-1 chain

1 7.283032 4.53 64.8 1 K.LKGTEDELDKYSEALKDAQEK.L1 6.9531 4.25 86.4 1 K.GTEDELDKYSEALK.D1 8.733254 4.28 74.1 1 K.GTEDELDKYSEALKDAQEK.L1 6.720276 4.31 53.7 1 K.GTEDELDKYSEALKDAQEKLELAEK.K1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G1 5.0176 4.57 65.9 1 R.AQKDEEKMEIQEIQLK.E1 5.05925 4.72 100 1 R.KLVIIESDLER.A1 5.572603 4.57 70.8 1 R.KLVIIESDLERAEER.A1 6.015606 4.57 55.3 2 R.KLVIIESDLERAEER.A1 5.056613 4.25 90.9 1 K.LVIIESDLERAEER.A

Tax_Id=10090 Gene_Symbol=Mgst1 Microsomal glutathione S-transferase 1 Tax_Id=10090 Gene_Symbol=Mgst1 26 kDa protein

1 7.767704 4.46 95.5 1 K.VFANPEDCAGFGK.G1 7.9701 5.52 37.6 1 R.AHLNDLENIVPFLGIGLLYSLSGPDLSTALMHFR.I

Tax_Id=10090 Gene_Symbol=Tpm3 Tropomyosin 3, gamma Tax_Id=10090 Gene_Symbol=Tpm3 Isoform 1 of Tropomyosin alpha-3 chain

1 7.283032 4.53 64.8 1 K.LKGTEDELDKYSEALKDAQEK.L1 6.9531 4.25 86.4 1 K.GTEDELDKYSEALK.D1 8.733254 4.28 74.1 1 K.GTEDELDKYSEALKDAQEK.L1 6.720276 4.31 53.7 1 K.GTEDELDKYSEALKDAQEKLELAEK.K1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G1 7.133857 4.57 84 1 R.ALKDEEKMELQEIQLK.E1 4.320869 4.72 94.4 1 R.KLVIIEGDLER.T1 6.390039 4.57 79.2 1 R.KLVIIEGDLERTEER.A

Tax_Id=10090 Gene_Symbol=Xrcc5 ATP-dependent DNA helicase 2 subunit 2 1 9.200518 4.4 92.3 1 R.HLMLPDFDLLEDIGNK.I2 4.818972 4.4 60.9 1 R.HLMLPDFDLLEDIGNK.I1 5.934298 5 44.8 2 K.NGEPGERGDLDSGLDHLKPSFPQK.G1 7.278157 3.8 69 1 R.VMLSLEGEDGLDEIYSFSESLR.Q1 6.581419 3.95 76.9 1 K.ETVYCLNDDDETEVSKEDTIQGYR.Y1 10.02093 4.25 84.4 2 K.DDEAAAVALSSLVHALDELNMVAIVR.Y1 7.227475 4.25 45.8 2 K.DDEAAAVALSSLVHALDELNMVAIVR.Y1 7.469705 3.96 69.2 2 K.DAYECLVYVQLPFMEDLR.Q1 8.611482 4.12 76.9 2 K.KNEEEDIVEDLFPTSK.I1 5.173839 4.12 67.4 1 K.KNEEEDIVEDLFPTSK.I1 10.06282 4.4 90.3 1 K.NQVTAQDVFQDNHEEGPAAK.K1 5.592042 4.25 38.9 1 K.IASFEEASLQLISHIEQFLDTNETLYFMK.S1 8.915354 3.89 58.1 1 K.DKAKEDTTGPEEAGDVDDLLDMI.-

Tax_Id=10090 Gene_Symbol=Hspa8 Heat shock cognate 71 kDa protein Tax_Id=10090 Gene_Symbol=Hspa8 Hspa8 protein

1 5.409415 4.46 94.7 4 K.VEIIANDQGNR.T1 7.799788 6.56 95.8 1 K.NQVAMNPTNTVFDAK.R1 5.870725 4.72 80 2 R.RFDDAVVQSDMK.H1 8.20654 4.46 82.6 1 K.SFYPEEVSSMVLTK.M2 5.984697 6.56 75.8 1 K.MKEIAEAYLGK.T1 5.35944 4.72 100 1 R.ARFEELNADLFR.G1 4.931673 4.72 68.6 1 R.ARFEELNADLFR.G1 6.608333 4.14 100 2 R.FEELNADLFR.G1 11.63837 4.14 85.3 1 K.SINPDEAVAYGAAVQAAILSGDK.S1 7.828115 4.14 52.5 2 K.SINPDEAVAYGAAVQAAILSGDK.S1 9.594308 4.14 75 2 K.QTQTFTTYSDNQPGVLIQVYEGER.A

20 6.943195 4.25 31.5 3 K.FELT(79.9663)GIPPAPRGVPQIEVTFDIDANGILNVSAVDK.S1 8.688237 3.96 70 43 R.GVPQIEVTFDIDANGILNVSAVDK.S

60 4.247204 4.69 33.9 1 K.ILDKCNEIISWLDKNQTAEKEEFEHQQKELEK.V1 6.140386 4.46 100 3 K.CNEIISWLDK.N1 6.804804 4.71 60.3 1 K.CNEIISWLDKNQTAEKEEFEHQQK.E

1 8.043078 4.89 87 13 K.NQTAEKEEFEHQQK.E1 8.186607 4.71 88 1 K.NQTAEKEEFEHQQKELEK.V1 5.634913 4.71 53.8 1 K.NQTAEKEEFEHQQKELEK.V

Tax_Id=10090 Gene_Symbol=Sgpl1 7 kDa protein Tax_Id=10090 Gene_Symbol=Sgpl1 23 kDa protein Tax_Id=10090 Gene_Symbol=Sgpl1 12 kDa protein

1 5.048518 4.4 72.7 2 K.LKDFEPYLEILESYSTK.ATax_Id=10090 Gene_Symbol=Bhmt Putative uncharacterized protein

1 8.974636 4.72 84 1 K.AGPWTPEAAVEHPEAVR.Q1 9.367806 4.72 75 3 R.AGSNVMQTFTFYASEDKLENR.G1 10.68248 4.14 79.4 1 R.QVADEGDALVAGGVSQTPSYLSCK.S1 6.327555 4.14 52.4 1 R.QVADEGDALVAGGVSQTPSYLSCK.S

Tax_Id=10090 Gene_Symbol=Actg1 Gamma actin-like protein 1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G1 9.181855 4.72 70.4 1 R.VAPEEHPVLLTEAPLNPK.R1 6.957728 5.52 46.1 1 R.TTGIVMDSGDGVTHTVPIYEGYALPHAILR.L1 9.645959 6.56 100 1 R.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.S1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.S1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.S1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.S1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F

Tax_Id=10090 Gene_Symbol=Clns1a Chloride channel, nucleotide-sensitive, 1A, isoform CRA_b 1 5.442837 5.63 65.4 1 R.DPNAYPQEHLYVMVNAK.L1 6.763752 3.71 47.9 4 K.LGEESKEPLS(79.9663)DEDEEDNDDVEPISEFR.F1 7.701669 3.64 62.1 1 R.NYEDGMEVETTPTVAGQFEDADVDH.-

Tax_Id=10090 Gene_Symbol=Gm9892 similar to Eif2s2 protein 1 6.776653 4.28 61.4 1 K.KKPFMLDEEGDAQTEETQPSETK.E1 6.531729 4.57 89.3 1 R.KKDASDDLDDLNFFNQK.K1 7.647456 4.57 77.8 1 R.KKDASDDLDDLNFFNQK.K1 8.108947 3.86 91.7 1 K.DASDDLDDLNFFNQK.K1 7.510388 4.42 84.6 1 K.KIFDIDEAEEAIKDVK.I1 6.561015 4.42 68.8 1 K.KIFDIDEAEEAIKDVK.I1 6.394126 4.12 96 1 K.IFDIDEAEEAIKDVK.I1 4.327377 4.12 62.2 1 K.IFDIDEAEEAIKDVK.I3 6.399762 4.02 30.2 1 K.FPEEDEILEKDEALEDEDSKKDDGISFSSQTAWAGSER.D

Tax_Id=10090 Gene_Symbol=Rps18 40S ribosomal protein S18 Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein Tax_Id=10090 Gene_Symbol=Gm10260 similar to ribosomal protein Tax_Id=10090 Gene_Symbol=Gm11361;LOC100047329 MCG116671

1 5.802982 4.25 95 8 K.RAGELTEDEVER.V4 5.365396 4.25 69.7 1 K.RAGELTEDEVER.V1 5.668098 4.57 51.9 1 K.RAGELTEDEVERVITIMQNPR.Q1 5.895633 5.02 54 1 K.DGKYSQVLANGLDNKLREDLER.L1 5.757286 6.56 85 1 K.YSQVLANGLDNK.L2 5.434835 4.89 55.6 1 K.YSQVLANGLDNKLREDLER.L

13 5.41167 4.89 50 1 K.YSQVLANGLDNKLREDLER.L

Tax_Id=10090 Gene_Symbol=Tpm1 33 kDa protein Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 7 Tax_Id=10090 Gene_Symbol=Tpm1 28 kDa protein Tax_Id=10090 Gene_Symbol=Tpm1 29 kDa protein

1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G1 5.0176 4.57 65.9 1 R.AQKDEEKMEIQEIQLK.E1 5.05925 4.72 100 1 R.KLVIIESDLER.A1 5.572603 4.57 70.8 1 R.KLVIIESDLERAEER.A1 6.015606 4.57 55.3 2 R.KLVIIESDLERAEER.A1 5.056613 4.25 90.9 1 K.LVIIESDLERAEER.A1 8.198394 4.53 76.9 2 K.ALMAAEDKYSQKEDKYEEEIK.V1 6.153659 4.53 64.8 1 K.ALMAAEDKYSQKEDKYEEEIK.V

Tax_Id=10090 Gene_Symbol=Pura;LOC100045958 Transcriptional activator protein Pur-alpha Tax_Id=10090 Gene_Symbol=LOC100045958 similar to hCG45299 isoform 3 Tax_Id=10090 Gene_Symbol=LOC100045958 similar to hCG45299 isoform 2

4 5.893162 4.42 35 2 R.DYLGDFIEHYAQLGPSQPPDLAQAQDEPRR.A1 6.479773 3.64 73.3 1 K.LIDDYGVEEEPAELPEGTSLTVDNK.R2 6.790565 3.95 64.5 2 K.LIDDYGVEEEPAELPEGTSLTVDNKR.F1 8.075751 3.95 42.5 2 K.LIDDYGVEEEPAELPEGTSLTVDNKR.F1 8.389796 3.89 39.8 1 K.RAACEQLHQQQQQQQEETTAATLLLQGEEEGEED.-

Tax_Id=10090 Gene_Symbol=Gm8759;Gm10191;Rpl31 60S ribosomal protein L31 Tax_Id=10090 Gene_Symbol=LOC638399 hypothetical protein isoform 1

6 6.189113 6.34 39.7 1 R.KRNEDEDSPNKLYTLVTYVPVTTFK.N1 8.432633 4.4 82.8 5 R.NEDEDSPNKLYTLVTYVPVTTFK.N

21 6.361837 4.4 42.1 1 R.NEDEDSPNKLYTLVTYVPVTTFK.N1 5.976572 3.55 100 1 K.NLQTVNVDEN.-

Tax_Id=10090 Gene_Symbol=P4hb Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=P4hb Protein disulfide-isomerase

1 7.411872 3.96 84.6 1 K.VDATEESDLAQQYGVR.G1 6.126352 3.96 65.9 1 K.VDATEESDLAQQYGVR.G1 6.155643 4.14 80 5 R.EADDIVNWLK.K1 7.263517 3.96 38.6 1 R.TGPAATTLSDTAAAESLVDSSEVTVIGFFK.D

20 6.448351 4.03 32.6 2 R.TGPAATTLSDTAAAESLVDSSEVTVIGFFKDVESDSAK.Q1 5.322637 4.4 90 1 K.YKPESDELTAEK.I1 8.131106 3.96 83.3 1 K.VLVGANFEEVAFDEK.K1 7.097727 4.14 100 1 K.MDSTANEVEAVK.V1 4.088545 3.38 37.3 1 K.FLESGGQDGAGDDEDLDLEEALEPDMEEDDDQK.A1 4.669322 3.57 31 1 K.FLESGGQDGAGDDEDLDLEEALEPDMEEDDDQKAVKDEL.-

Tax_Id=10090 Gene_Symbol=Csda DbpA murine homologue Tax_Id=10090 Gene_Symbol=Csda Csda protein Tax_Id=10090 Gene_Symbol=Csda Isoform 2 of DNA-binding protein A

1 9.728408 3.8 92.3 2 R.SVGDGETVEFDVVEGEK.G1 7.088382 3.89 38.6 2 R.SVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSR.Y1 7.83328 4.14 86.2 1 K.GAEAANVTGPDGVPVEGSR.Y

1 9.522781 4.89 75 1 R.NAGEIGEMKDGVPEGTQLQAHR.N2 7.936372 4.89 43.1 1 R.PRPAPAIGEAEDKENQQAANGPNQPSAR.R1 6.854197 4.4 44.3 2 R.PAPAIGEAEDKENQQAANGPNQPSAR.R

Tax_Id=10090 Gene_Symbol=Gpx1 Glutathione peroxidase 1 1 5.123625 4.14 87.5 1 R.DYTEMNDLQK.R1 6.55862 4.14 66.7 1 R.NALPTPSDDPTALMTDPK.Y1 6.166824 4.46 100 1 R.NDIAWNFEK.F1 5.742528 4.46 100 1 R.NDIAWNFEK.F1 6.124124 3.34 64.3 1 R.TIDIEPDIETLLSQQSGNS.-1 7.682884 3.34 51.7 3 R.TIDIEPDIETLLSQQSGNS.-

Tax_Id=10090 Gene_Symbol=2900073G15Rik myosin light chain, regulatory B-like Tax_Id=10090 Gene_Symbol=2900073G15Rik Putative uncharacterized protein

1 5.965439 4.46 86.7 1 K.EAFNMIDQNR.D1 9.450089 4.58 88.9 1 R.DGFIDKEDLHDMLASMGK.N1 7.697502 4.58 60.4 1 R.DGFIDKEDLHDMLASMGK.N1 5.771833 4.58 54.1 1 R.DGFIDKEDLHDMLASMGK.N1 4.332873 4.03 71.4 1 R.ELLTTMGDRFTDEEVDELYR.E1 5.725149 4.03 52.8 1 R.ELLTTMGDRFTDEEVDELYR.E1 6.686996 3.86 100 1 R.FTDEEVDELYR.E

Tax_Id=10090 Gene_Symbol=Actb Cytoskeletal beta-actin (Fragment) 1 9.645959 6.56 100 1 R.GYSFTTTAER.E1 4.414664 4.42 41.4 1 R.DIKEKLCYVALDFEQEMATAASSSSLEK.G1 7.599438 4.25 89.3 1 K.EKLCYVALDFEQEMATAASSSSLEK.G1 6.353089 4.25 45.7 1 K.EKLCYVALDFEQEMATAASSSSLEK.G1 10.12075 3.96 78.1 10 K.LCYVALDFEQEMATAASSSSLEK.G1 7.969572 3.96 56.7 11 K.LCYVALDFEQEMATAASSSSLEK.G

Tax_Id=10090 Gene_Symbol=Myl6 Isoform Smooth muscle of Myosin light polypeptide 6 1 7.971284 4.4 83.3 2 K.NKDQGTYEDYVEGLR.V1 5.92978 4.4 80.5 1 K.NKDQGTYEDYVEGLR.V1 7.658019 3.96 86.4 1 K.DQGTYEDYVEGLR.V1 7.452262 3.95 51.5 2 K.MTEEEVEMLVAGHEDSNGCINYEELVR.M

Tax_Id=10090 Gene_Symbol=Rpl10a 7 kDa protein 1 6.172373 5.8 66.7 2 R.DTLYEAVREVLHGNQR.K

Tax_Id=10090 Gene_Symbol=Prmt5 Protein 33 7.415211 4.03 30.3 1 K.GYEDYLQSPLQPLMDNLESQTYEVFEKDPIK.Y

1 6.815834 4.57 54.7 1 K.CLLDRVPEEEKETNVQVLMVLGAGR.G2 4.048878 4.4 47.5 2 R.VPEEEKETNVQVLMVLGAGR.G

Tax_Id=10090 Gene_Symbol=Gm8730 similar to Acidic ribosomal phosphoprotein P0 1 5.409174 4.4 81.8 1 K.EDLTEIRDMLLANK.V1 5.541959 4.46 71 1 R.AGAIAPCEVTVPAQNTGLGPEK.T1 7.536709 4.4 47.4 1 F.SFGLIIQQVFDNGSIYNPEVLDITEQALHSR.F1 8.19238 3.58 85.2 4 K.AEAKEESEESDEDMGFGLFD.-1 7.182205 3.58 69.2 3 K.AEAKEES(79.9663)EES(79.9663)DEDMGFGLFD.-

Tax_Id=10090 Gene_Symbol=Tpm2 Tropomyosin 2 beta 1 4.942474 4.25 56.5 1 K.GTEDEVEKYSESVK.D1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A

1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.LTax_Id=10090 Gene_Symbol=Stk38 Putative uncharacterized protein

2 6.371 4.72 61.5 1 K.VTLENFYSNLIAQHEER.E1 5.15934 4.42 73.7 1 K.VMEEEGLKDEEKR.L1 8.585593 4.7 44.2 2 K.KDTLTEEETQFYIAETVLAIDSIHQLGFIHR.D1 5.989231 4.72 78.9 1 R.DIKPDNLLLDSK.V

Tax_Id=10090 Gene_Symbol=Gm13072;Trmt112 tRNA methyltransferase 112 homolog Tax_Id=10090 Gene_Symbol=- hypothetical protein Tax_Id=10090 Gene_Symbol=Trmt112 MCG130245, isoform CRA_b

1 5.628145 4.2 39.8 1 K.VEWAALVQAADTLNLAEVPKEPTEGYEHDETFLR.KTax_Id=10090 Gene_Symbol=Snrpe Small nuclear ribonucleoprotein E

1 6.759657 4.03 51.5 2 R.IEGCIIGFDEYMNLVLDDAEEIHSK.TTax_Id=10090 Gene_Symbol=LOC100044912 similar to 14-3-3 protein theta-subtype

1 6.830123 4.14 100 1 R.YLAEVACGDDR.K1 7.530107 4.72 100 5 R.YLAEVACGDDRK.Q1 11.27122 4.72 93.3 1 R.KQTIENSQGAYQEAFDISK.K1 7.611524 6.56 51.9 1 R.KQTIENSQGAYQEAFDISKK.E1 8.112727 4.14 96.6 1 K.QTIENSQGAYQEAFDISK.K

Tax_Id=10090 Gene_Symbol=Banf1 Barrier-to-autointegration factor 1 9.990572 4.4 66.7 1 R.DFVAEPMGEKPVGSLAGIGDVLSK.R1 6.980736 4.4 45.5 1 R.DFVAEPMGEKPVGSLAGIGDVLSK.R

Tax_Id=10090 Gene_Symbol=Uqcrq 4 kDa protein 1 6.37672 6.56 87.5 1 R.KNPAMYENDK.-

Tax_Id=10090 Gene_Symbol=LOC100046223 similar to insulinoma protein (rig) isoform 1 9 6.069873 4.4 37.3 1 K.FTYRGVDLDQLLDMSYEQLMQLYSAR.Q1 10.08958 3.34 81.5 1 R.GVDLDQLLDMSYEQLMQLY.S1 8.937484 3.96 80.8 4 R.GVDLDQLLDMSYEQLMQLYSAR.Q1 7.477458 3.96 47.5 4 R.GVDLDQLLDMSYEQLMQLYSAR.Q1 6.574386 6.56 70.3 1 K.KEAPPMEKPEVVK.T1 5.394371 4.72 75 1 K.EAPPMEKPEVVK.T

Tax_Id=10090 Gene_Symbol=Myh9 Myosin-9 1 8.519996 4.4 72.4 1 K.VEDMAELTCLNEASVLHNLK.E1 8.416608 4.14 100 1 K.NLPIYSEEIVEMYK.G1 7.822263 4.4 82.8 1 R.SMMQDREDQSILCTGESGAGK.T1 3.994156 4.4 55.6 1 R.SMMQDREDQSILCTGESGAGK.T1 7.184726 4.72 85.7 1 K.NMDPLNDNIATLLHQSSDK.F1 5.814803 4.72 100 1 R.AGVLAHLEEER.D1 6.436563 4.14 100 1 R.LTEMETMQSQLMAEK.L

15 7.296098 3.8 44.8 1 K.LQLQEQLQAETELCAEAEELR.A1 7.212151 4.58 100 2 K.KQELEEICHDLEAR.V1 8.846653 4.03 88.9 2 K.KMQQNIQELEEQLEEEESAR.Q1 5.995075 4.03 63.5 1 K.KMQQNIQELEEQLEEEESAR.Q1 5.629617 3.69 61.2 1 K.MQQNIQELEEQLEEEESAR.Q1 9.035634 4.25 100 4 K.KLEEDQIIMEDQNCK.L1 5.231796 4.25 73.7 1 K.KLEEDQIIMEDQNCK.L1 7.116184 3.86 100 2 K.LEEDQIIMEDQNCK.L1 6.096013 4.28 60.8 1 K.LLEDRVAEFTTNLMEEEEKSK.S1 7.97655 3.86 95.5 1 R.VAEFTTNLMEEEEK.S

1 8.328828 4.25 88 1 R.VAEFTTNLMEEEEKSK.S1 8.363364 4.89 95.5 1 K.NKHEAMITDLEER.L1 5.294311 4.89 80 1 K.NKHEAMITDLEER.L1 8.125869 4.42 76.7 2 R.RKLEGDSTDLSDQIAELQAQIAELK.M1 7.837013 4.42 56.1 1 R.RKLEGDSTDLSDQIAELQAQIAELK.M1 9.20504 4.12 96.7 2 R.KLEGDSTDLSDQIAELQAQIAELK.M1 5.416637 4.12 45.7 1 R.KLEGDSTDLSDQIAELQAQIAELK.M1 9.927542 3.8 87.1 1 K.LEGDSTDLSDQIAELQAQIAELK.M1 6.628753 3.8 50.8 1 K.LEGDSTDLSDQIAELQAQIAELK.M1 9.013904 4.03 89.3 1 K.IRELETQISELQEDLESER.A1 4.905222 3.69 57.1 1 R.ELETQISELQEDLESER.A1 8.204671 3.89 92.6 2 R.DLGEELEALKTELEDTLDSTAAQQELR.S6 4.957843 3.89 38 1 R.DLGEELEALKTELEDTLDSTAAQQELR.S1 6.574404 3.89 35.1 1 R.DLGEELEALKTELEDTLDSTAAQQELR.S1 7.980735 4.58 85.7 2 K.TLEDEAKTHEAQIQEMR.Q1 5.233869 4.58 49 1 K.TLEDEAKTHEAQIQEMR.Q1 5.622465 4.4 80.5 1 K.HSQAVEELADQLEQTK.R1 9.301572 4.89 82.8 1 K.HSQAVEELADQLEQTKR.V1 5.688477 4.4 84 2 K.QTLENERGELANEVK.A1 8.005088 3.8 96.4 4 K.DFSALESQLQDTQELLQEENR.Q

24 4.602604 3.8 47.1 1 K.DFSALESQLQDTQELLQEENR.Q1 4.360732 4.12 43.1 2 K.DFSALESQLQDTQELLQEENRQK.L1 8.138877 4.25 96.2 3 K.KMEDGVGCLETAEEAK.R1 6.582212 4.57 63.8 1 K.KMEDGVGCLETAEEAKR.R1 8.410017 3.86 96 2 K.MEDGVGCLETAEEAK.R1 9.906777 4.25 92 1 R.LQQELDDLLVDLDHQR.Q1 7.248398 4.25 95.8 1 R.TEMEDLMSSKDDVGK.S1 8.968273 3.69 100 6 K.TQLEELEDELQATEDAK.L1 6.917202 4.72 100 7 K.DLEAHIDTANK.N

19 4.982577 3.86 41.9 1 K.SMEAEMIQLQEELAAAER.A1 6.511397 4.57 56.7 1 K.RQAQQERDELADEIANSSGK.G1 7.916503 4.25 80 2 R.QAQQERDELADEIANSSGK.G1 5.860516 4.25 56.9 1 R.QAQQERDELADEIANSSGK.G1 6.668336 3.96 76.2 1 R.DELADEIANSSGK.G1 8.28302 3.64 82.1 5 R.IAQLEEELEEEQGNTELINDR.L

44 6.700479 3.64 39.3 2 R.IAQLEEELEEEQGNTELINDR.L1 5.223573 3.95 50.8 1 R.IAQLEEELEEEQGNTELINDRLK.K1 6.971178 4.25 87.5 1 K.IAQLEEQLDNETKER.Q1 5.202978 4.72 100 1 R.NAEQFKDQADK.A1 8.078432 3.86 95.2 1 R.ELEDATETADAMNR.E

Tax_Id=10090 Gene_Symbol=Gm15501;Rps8 40S ribosomal protein S8 Tax_Id=10090 Gene_Symbol=- 24 kDa protein

1 7.188132 4.46 82.6 1 R.LDVGNFSWGSECCTR.K3 4.788437 3.96 82.4 2 K.LTPEEEEILNK.K1 7.853041 4.46 100 1 K.ISSLLEEQFQQGK.L1 6.361469 4.46 93.3 4 R.ADGYVLEGK.E1 7.65671 4.4 88 1 R.ADGYVLEGKELEFYLR.K1 7.294963 4.4 64.4 1 R.ADGYVLEGKELEFYLR.K

Tax_Id=10090 Gene_Symbol=Ncl Nucleolin 1 6.585094 4.46 83.3 2 K.VEGSEPTTPFNLFIGNLNPNK.S1 6.064924 4.46 93.3 1 K.NDLAVVDVR.T1 8.642188 4.25 100 1 R.KFGYVDFESAEDLEK.A1 4.386056 4.25 69.2 1 R.KFGYVDFESAEDLEK.A1 7.275721 4.42 66.7 1 R.KFGYVDFESAEDLEKALELTGLK.V1 10.4885 3.86 95.7 2 K.FGYVDFESAEDLEK.A1 6.612456 4.14 90 1 K.NLSFNITEDELK.E1 8.942158 4.03 92.3 5 K.NLSFNITEDELKEVFEDAMEIR.L1 6.520793 4.03 63.8 10 K.NLSFNITEDELKEVFEDAMEIR.L1 9.904948 4.03 82.1 1 F.NITEDELKEVFEDAMEIR.L1 6.690878 3.96 100 1 K.EVFEDAMEIR.L1 5.758101 4.42 54.7 2 K.GIAYIEFKSEADAEKNLEEK.Q1 9.604829 4.4 73.3 1 K.TLVLSNLSYSATKETLEEVFEK.A1 5.18385 3.96 92.9 1 K.ETLEEVFEK.A1 7.794051 4.14 100 1 K.GYAFIEFASFEDAK.E1 6.819659 3.96 94.7 1 K.GLSEDTTEETLK.E1 10.54569 4.12 75.9 2 K.GLSEDTTEETLKESFEGSVR.A1 7.566001 4.12 67.3 1 K.GLSEDTTEETLKESFEGSVR.A1 6.786043 3.96 84.2 1 K.GFGFVDFNSEEDAK.A1 8.35371 3.96 95.5 1 K.GFGFVDFNSEEDAK.A1 6.672139 4.12 84.4 1 K.EAMEDGEIDGNKVTLDWAK.P1 7.626455 4.42 75.9 5 K.EAMEDGEIDGNKVTLDWAKPK.G3 4.812409 4.42 50 1 K.EAMEDGEIDGNKVTLDWAKPK.G

Tax_Id=10090 Gene_Symbol=Hspa5 78 kDa glucose-regulated protein owl|P06761| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN... owl|P20029| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN...

2 8.97624 4.28 39.7 1 A.EEEDKKEDVGTVVGIDLGTTYSCVGVFK.N1 5.409415 4.46 94.7 4 R.VEIIANDQGNR.I1 6.206944 4.46 60.9 2 R.ITPSYVAFTPEGER.L1 7.081274 4.46 95.8 1 K.NQLTSNPENTVFDAK.R1 10.97651 3.8 85.2 61 R.IEIESFFEGEDFSETLTR.A1 6.592686 4.72 100 1 R.AKFEELNMDLFR.S1 7.431835 4.42 86.7 2 K.VLEDSDLKKSDIDEIVLVGGSTR.I2 5.898348 4.12 53.2 1 K.IEWLESHQDADIEDFK.A1 10.06747 4.42 85.7 1 K.IEWLESHQDADIEDFKAK.K6 4.953679 4.42 49 1 K.IEWLESHQDADIEDFKAK.K1 5.149179 4.14 94.7 1 K.ELEEIVQPIISK.L1 10.69346 3.8 65.6 7 K.LYGSGGPPPTGEEDTSEKDEL.-

Tax_Id=10090 Gene_Symbol=Atp5h ATP synthase subunit d, mitochondrial Tax_Id=10090 Gene_Symbol=LOC100044492;Gm10250 hypothetical protein

1 7.221914 4.28 75 1 K.IPVPEDKYTALVDQEEKEDVK.S1 5.061806 4.28 49.2 1 K.IPVPEDKYTALVDQEEKEDVK.S1 7.560277 4.25 95.8 1 K.YTALVDQEEKEDVK.S1 6.195091 3.86 80.8 1 R.NIIPFDQMTIDDLNEIFPETK.L

Tax_Id=10090 Gene_Symbol=- 13 kDa protein 1 7.952041 4.72 67.9 1 R.PSDECGAGVFMGSHFDR.H1 4.29579 4.72 59.1 1 R.PSDECGAGVFMGSHFDR.H

1 8.652838 6.23 81.8 1 K.CCLTYCFNKPEDK.-1 5.875928 6.23 70.6 1 K.CCLTYCFNKPEDK.-

Tax_Id=10090 Gene_Symbol=H2afj Histone H2A.J Tax_Id=10090 Gene_Symbol=Hist1h2an;Hist1h2ao;Hist1h2ad;Hist1h2ac;Hist1h2ae;Hist1h2ag;Hist1h2ai;RP23-480B19.10;Hist1h2ab Histone H2A type 1 Tax_Id=10090 Gene_Symbol=H2afx Histone H2A.x Tax_Id=10090 Gene_Symbol=Hist1h2ak Histone H2A type 1-K Tax_Id=10090 Gene_Symbol=Hist1h2ah Histone H2A type 1-H Tax_Id=10090 Gene_Symbol=Hist1h2af Histone H2A type 1-F Tax_Id=10090 Gene_Symbol=Hist3h2a Histone H2A type 3

1 8.010769 4.14 77.8 1 R.VGAGAPVYLAAVLEYLTAEILELAGNAAR.D1 8.35411 4.14 47.4 1 R.VGAGAPVYLAAVLEYLTAEILELAGNAAR.D

12 5.721669 4.4 34.6 1 R.VGAGAPVYLAAVLEYLTAEILELAGNAARDNK.K1 6.314499 4.89 38.6 1 R.VGAGAPVYLAAVLEYLTAEILELAGNAARDNKK.T2 6.03732 4.89 34.9 1 R.VGAGAPVYLAAVLEYLTAEILELAGNAARDNKK.T

Tax_Id=10090 Gene_Symbol=Ywhaz Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Ywhaz 5 kDa protein

1 7.331036 4.4 76.9 1 K.LAEQAERYDDMAACMK.S1 7.081261 4.4 66.7 1 K.LAEQAERYDDMAACMK.S1 7.23296 3.96 100 2 K.SVTEQGAELSNEER.N

no description1 7.547417 4.46 83.3 1 R.SNMDNMFESYINNLR.R1 9.959548 4.4 96.7 1 K.LKLEAELGNMQGLVEDFK.N1 6.602979 4.4 51 2 K.LKLEAELGNMQGLVEDFK.N1 6.185527 4.81 47.9 4 K.LKLEAELGNMQGLVEDFKNKYEDEINKR.T7 6.096478 4.81 34.5 1 K.LKLEAELGNMQGLVEDFKNKYEDEINKR.T8 5.16601 3.96 54.2 1 K.LEAELGNMQGLVEDFK.N1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T1 7.843509 4.14 94.4 1 R.TEMENEFVLIK.K1 5.245513 4.72 94.7 1 R.TEMENEFVLIKK.D1 6.799948 4.57 70.7 1 K.KDVDEAYMNKVELESR.L1 7.326807 4.14 100 6 K.DVDEAYMNK.V1 7.083211 4.14 92.9 7 K.DVDEAYMNK.V1 7.682394 4.25 91.7 1 K.DVDEAYMNKVELESR.L1 7.32119 4.14 100 1 R.LEGLTDEINFLR.Q1 8.335616 4.14 74.2 1 R.ELQSQISDTSVVLSMDNSR.S2 5.766051 4.46 83.3 1 K.AQYEDIANR.S1 8.004234 4.14 100 1 R.ASLEAAIADAEQR.G

Tax_Id=10090 Gene_Symbol=- 71 kDa protein 1 7.799788 6.56 95.8 1 K.NQVAMNPTNTVFDAK.R1 5.870725 4.72 80 2 R.RFDDAVVQSDMK.H2 5.984697 6.56 75.8 1 K.MKEIAEAYLGK.T1 5.35944 4.72 100 1 R.ARFEELNADLFR.G1 4.931673 4.72 68.6 1 R.ARFEELNADLFR.G1 6.608333 4.14 100 2 R.FEELNADLFR.G1 11.63837 4.14 85.3 1 K.SINPDEAVAYGAAVQAAILSGDK.S1 7.828115 4.14 52.5 2 K.SINPDEAVAYGAAVQAAILSGDK.S1 9.594308 4.14 75 2 K.QTQTFTTYSDNQPGVLIQVYEGER.A

20 6.943195 4.25 31.5 3 K.FELT(79.9663)GIPPAPRGVPQIEVTFDIDANGILNVSAVDK.S1 8.688237 3.96 70 43 R.GVPQIEVTFDIDANGILNVSAVDK.S

60 4.247204 4.69 33.9 1 K.ILDKCNEIISWLDKNQTAEKEEFEHQQKELEK.V1 6.140386 4.46 100 3 K.CNEIISWLDK.N1 6.804804 4.71 60.3 1 K.CNEIISWLDKNQTAEKEEFEHQQK.E1 8.043078 4.89 87 13 K.NQTAEKEEFEHQQK.E1 8.186607 4.71 88 1 K.NQTAEKEEFEHQQKELEK.V1 5.634913 4.71 53.8 1 K.NQTAEKEEFEHQQKELEK.V

Tax_Id=10090 Gene_Symbol=Syncrip Isoform 1 of Heterogeneous nuclear ribonucleoprotein Q Tax_Id=10090 Gene_Symbol=Syncrip Isoform 2 of Heterogeneous nuclear ribonucleoprotein Q

1 10.73818 4.42 62.3 1 K.VAEKLDEIYVAGLVAHSDLDER.A1 5.310761 4.42 45.7 1 K.VAEKLDEIYVAGLVAHSDLDER.A1 8.617219 4.25 83.3 1 K.LDEIYVAGLVAHSDLDER.A1 7.221235 4.25 62.5 1 K.LDEIYVAGLVAHSDLDER.A1 9.681186 4.4 96.7 1 R.AIEALKEFNEDGALAVLQQFK.D1 4.681716 4.4 63.3 1 R.AIEALKEFNEDGALAVLQQFK.D1 6.889669 4.71 44.2 2 R.AIEALKEFNEDGALAVLQQFKDSDLSHVQNK.S1 5.54703 4.71 33.9 1 R.AIEALKEFNEDGALAVLQQFKDSDLSHVQNK.S1 7.383991 4.14 88 3 K.EFNEDGALAVLQQFK.D1 4.749503 3.86 71.4 1 R.DLFEDELVPLFEK.A1 6.745249 4.4 70.4 1 K.VTEGLTDVILYHQPDDK.K1 6.064831 4.12 47.1 1 K.VKVWGNVGTVEWADPIEDPDPEVMAK.V1 8.067058 3.8 79.3 2 K.VWGNVGTVEWADPIEDPDPEVMAK.V1 6.242426 3.8 50 1 K.VWGNVGTVEWADPIEDPDPEVMAK.V1 8.09165 4.14 100 1 R.NLANTVTEEILEK.S1 5.908434 4.72 100 2 K.DYAFIHFDER.D1 5.061556 4.28 44.3 3 K.AMEEMNGKDLEGENIEIVFAKPPDQK.R

16 5.68956 4.28 36.4 1 K.AMEEMNGKDLEGENIEIVFAKPPDQK.R1 8.294055 4.25 65.5 3 K.DLEGENIEIVFAKPPDQK.R1 7.00272 4.25 59.2 1 K.DLEGENIEIVFAKPPDQK.R

Tax_Id=10090 Gene_Symbol=Sfrs1;LOC100048559 Isoform 1 of Splicing factor, arginine/serine-rich 1 Tax_Id=10090 Gene_Symbol=Sfrs1 Isoform 3 of Splicing factor, arginine/serine-rich 1 Tax_Id=10090 Gene_Symbol=Sfrs1 Isoform 2 of Splicing factor, arginine/serine-rich 1

1 5.730215 4.72 93.8 1 R.TKDIEDVFYK.Y1 7.239538 4.12 64.3 2 R.GGPPFAFVEFEDPRDAEDAVYGR.D1 6.84926 4.14 86.7 1 R.DGYDYDGYR.L1 7.713511 4.14 100 1 R.EAGDVCYADVYR.D1 5.770952 6.56 100 1 R.KEDMTYAVR.K

Tax_Id=10090 Gene_Symbol=Mccc2 Putative uncharacterized protein 1 10.28131 4.25 93.5 2 K.AATGEEVSAEDLGGADLHCR.K1 6.353033 4.25 62.1 2 K.AATGEEVSAEDLGGADLHCR.K1 7.767264 3.8 72.4 3 K.MDVTIEPSEEPLFPADELYGIVGANLK.R

14 4.362507 3.8 33.8 1 K.MDVTIEPSEEPLFPADELYGIVGANLK.RTax_Id=10090 Gene_Symbol=Hnrnpk Isoform 1 of Heterogeneous nuclear ribonucleoprotein K Tax_Id=10090 Gene_Symbol=Hnrnpk Isoform 2 of Heterogeneous nuclear ribonucleoprotein K

1 8.726964 4.25 95.5 1 K.RPAEDMEEEQAFK.R1 7.049439 4.57 79.2 1 K.RPAEDMEEEQAFKR.S1 5.027413 4.57 78.9 2 K.RPAEDMEEEQAFKR.S

1 7.901464 4.14 82.1 1 R.TDYNASVSVPDSSGPER.I1 4.656957 4.25 21.2 1 K.IIPTLEEGLQLPS(79.9663)PTATSQLPLESDAVECLNYQHYK.G1 4.325107 4.14 92.3 3 R.DYDDMSPR.R1 10.00257 4.42 83.9 1 R.HESGASIKIDEPLEGSEDR.I1 6.736864 3.86 100 12 K.IDEPLEGSEDR.I1 7.094238 4.12 37.5 1 K.IDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVK.Q

Tax_Id=10090 Gene_Symbol=Bhmt Betaine--homocysteine S-methyltransferase 1 Tax_Id=10090 Gene_Symbol=Bhmt-ps1 Betaine-homocysteine methyltransferase, pseudogene 1

1 8.974636 4.72 84 1 K.AGPWTPEAAVEHPEAVR.Q1 9.367806 4.72 75 3 R.AGSNVMQTFTFYASEDKLENR.G1 10.68248 4.14 79.4 1 R.QVADEGDALVAGGVSQTPSYLSCK.S1 6.327555 4.14 52.4 1 R.QVADEGDALVAGGVSQTPSYLSCK.S1 5.600281 4.42 48.5 1 K.KNVDFLIAEYFEHVEEAVWAVEALK.A1 11.14285 4.12 92.3 3 K.NVDFLIAEYFEHVEEAVWAVEALK.A1 6.937293 4.12 57.1 3 K.NVDFLIAEYFEHVEEAVWAVEALK.A

10 5.848093 4.14 48 1 K.QGFIDLPEFPFGLEPR.VTax_Id=10090 Gene_Symbol=Rpl10a;Gm15451 ribosomal protein L10A

1 6.172373 5.8 66.7 2 R.DTLYEAVREVLHGNQR.K1 8.899151 4.72 84.6 1 K.FSVCVLGDQQHCDEAK.A6 4.876205 4.72 61.5 1 K.FSVCVLGDQQHCDEAK.A1 8.066259 4.72 65.5 1 K.MTDDELVYNIHLAVNFLVSLLK.K

Tax_Id=10090 Gene_Symbol=Rplp0 16 kDa protein 1 5.409174 4.4 81.8 1 K.EDLTEIRDMLLANK.V1 5.541959 4.46 71 1 R.AGAIAPCEVTVPAQNTGLGPEK.T

Tax_Id=10090 Gene_Symbol=Dynll1 Dynein light chain 1, cytoplasmic 1 9.543701 3.8 82.8 1 K.NADMSEEMQQDSVECATQALEK.Y

Tax_Id=10090 Gene_Symbol=Dynll2 Dynein light chain 2, cytoplasmic Tax_Id=10090 Gene_Symbol=Dynll2 6 kDa protein

1 10.29034 3.8 86.2 1 K.NADMSEDMQQDAVDCATQAMEK.Y1 7.265049 3.8 63.8 1 K.NADMSEDMQQDAVDCATQAMEK.Y

Tax_Id=10090 Gene_Symbol=Eef1d MCG22130, isoform CRA_b Tax_Id=10090 Gene_Symbol=Eef1d 22 kDa protein Tax_Id=10090 Gene_Symbol=Eef1d 61 kDa protein Tax_Id=10090 Gene_Symbol=Eef1d eukaryotic translation elongation factor 1 delta isoform b

1 5.886336 3.87 42.5 1 K.GATPAEDDEDKDIDLFGS(79.9663)DEEEEDKEAAR.L10 4.593334 4.41 33.3 1 R.KLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNK.I

Tax_Id=10090 Gene_Symbol=Ssb Sjogren syndrome antigen B Tax_Id=10090 Gene_Symbol=Ssb 19 kDa protein

1 6.737861 4.89 70.4 1 R.SPSRPLPEVTDEYKNDVK.N1 8.100573 4.12 73.1 1 K.GFPTDATLDDIKEWLDDK.G1 7.457218 4.42 42.9 4 K.GFPTDATLDDIKEWLDDKGQILNIQMR.R

Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 10 Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 8 Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 6 Tax_Id=10090 Gene_Symbol=Tpm1 tropomyosin 1 alpha chain isoform 2 Tax_Id=10090 Gene_Symbol=Tpm1 29 kDa protein

1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L

1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G1 5.0176 4.57 65.9 1 R.AQKDEEKMEIQEIQLK.E1 5.05925 4.72 100 1 R.KLVIIESDLER.A1 5.572603 4.57 70.8 1 R.KLVIIESDLERAEER.A1 6.015606 4.57 55.3 2 R.KLVIIESDLERAEER.A1 5.056613 4.25 90.9 1 K.LVIIESDLERAEER.A

Tax_Id=10090 Gene_Symbol=Hspa8 17 kDa protein Tax_Id=10090 Gene_Symbol=Hspa8 13 kDa protein

1 5.409415 4.46 94.7 4 K.VEIIANDQGNR.T1 7.799788 6.56 95.8 1 K.NQVAMNPTNTVFDAK.R1 5.870725 4.72 80 2 R.RFDDAVVQSDMK.H

Tax_Id=10090 Gene_Symbol=Mccc2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 1 9.176686 4.14 89.3 1 R.LGTQPDSASSTYQENYEQMK.A1 6.832533 4.03 27.9 2 R.DRIDNLIDPGSPFLEFSQFAGYQLYGDEEVPAGGIITGIGR.V1 10.28131 4.25 93.5 2 K.AATGEEVSAEDLGGADLHCR.K1 6.353033 4.25 62.1 2 K.AATGEEVSAEDLGGADLHCR.K1 7.767264 3.8 72.4 3 K.MDVTIEPSEEPLFPADELYGIVGANLK.R

14 4.362507 3.8 33.8 1 K.MDVTIEPSEEPLFPADELYGIVGANLK.R1 7.417867 4.72 79.2 1 K.RFEEEGNPYYSSAR.L1 6.231418 3.96 86.4 1 R.LWDDGIIDPVDTR.L

Tax_Id=10090 Gene_Symbol=Rps5 20 kDa protein Tax_Id=10090 Gene_Symbol=Rps5 ribosomal protein S5

7 5.318247 6.51 36.5 1 K.HAFEIIHLLTGENPLQVLVNAIINSGPR.E1 9.225581 4.14 100 1 K.TIAECLADELINAAK.-

Tax_Id=10090 Gene_Symbol=Cbx3 Chromobox homolog 3 Tax_Id=10090 Gene_Symbol=Cbx3 13 kDa protein

1 7.454795 4.12 100 2 K.KVEEAEPEEFVVEK.V1 5.478134 3.64 41.1 1 K.GFTDADNTWEPEENLDCPELIEAFLNSQK.A

Tax_Id=10090 Gene_Symbol=Echs1 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, isoform CRA_c 9 6.285866 3.8 31.8 1 K.ALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDK.A

Tax_Id=10090 Gene_Symbol=Fam82a2 Novel protein Tax_Id=10090 Gene_Symbol=Fam82a2 Novel protein Tax_Id=10090 Gene_Symbol=Fam82a2 Novel protein

1 8.452296 5.63 92.3 1 R.SHS(79.9663)LPNSLDYAQASER.G3 5.556239 5.63 69 1 R.S(79.9663)HSLPNSLDYAQASER.G

Tax_Id=10090 Gene_Symbol=Gstm1 Glutathione S-transferase Mu 1 1 4.609347 3.96 85.7 1 R.MLLEYTDSSYDEK.R1 7.440577 4.4 95.5 1 R.MLLEYTDSSYDEKR.Y1 4.34949 4.72 80 1 K.RYTMGDAPDFDR.S1 7.550836 4.14 88.9 1 R.YTMGDAPDFDR.S1 7.568022 4.14 94.4 1 R.ADIVENQVMDTR.M1 5.748845 4.46 81.8 1 R.MQLIMLCYNPDFEK.Q

Tax_Id=10090 Gene_Symbol=Rps2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Rps2;Gm14583;Gm8553 40S ribosomal protein S2 Tax_Id=10090 Gene_Symbol=Gm5786 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm16408 hypothetical protein

1 4.905957 4.72 94.4 1 K.AEDKEWIPVTK.L5 7.539693 4.28 37.2 6 K.SLEEIYLFSLPIKESEIIDFFLGASLKDEVLK.I1 9.916904 4.25 86.7 3 K.ESEIIDFFLGASLKDEVLK.I1 6.655554 5.63 94.4 1 K.SPYQEFTDHLVK.T

Tax_Id=10090 Gene_Symbol=Cyb5b Cytochrome b5 type B 1 7.896435 4.12 45.9 1 R.FLSEHPGGEEVLLEQAGADATESFEDVGHSPDAR.E

owl|P07823| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN... 2 8.97624 4.28 39.7 1 A.EEEDKKEDVGTVVGIDLGTTYSCVGVFK.N1 5.409415 4.46 94.7 4 R.VEIIANDQGNR.I1 6.206944 4.46 60.9 2 R.ITPSYVAFTPEGER.L1 7.081274 4.46 95.8 1 K.NQLTSNPENTVFDAK.R1 10.97651 3.8 85.2 61 R.IEIESFFEGEDFSETLTR.A1 6.592686 4.72 100 1 R.AKFEELNMDLFR.S1 7.431835 4.42 86.7 2 K.VLEDSDLKKSDIDEIVLVGGSTR.I2 5.898348 4.12 53.2 1 K.IEWLESHQDADIEDFK.A1 10.06747 4.42 85.7 1 K.IEWLESHQDADIEDFKAK.K6 4.953679 4.42 49 1 K.IEWLESHQDADIEDFKAK.K1 5.149179 4.14 94.7 1 K.ELEEIVQPIISK.L

Tax_Id=10090 Gene_Symbol=Ass1 Argininosuccinate synthase 1 9.739512 4.12 79.3 2 K.EQGYDVIAYLANIGQKEDFEEAR.K1 6.501326 4.12 50.8 1 K.EQGYDVIAYLANIGQKEDFEEAR.K

14 5.370244 4.28 35.1 3 K.KVFIEDVSKEFVEEFIWPAVQSSALYEDR.Y1 7.874978 3.86 78.6 2 K.EFVEEFIWPAVQSSALYEDR.Y1 6.686368 3.86 54.5 1 K.EFVEEFIWPAVQSSALYEDR.Y1 6.30787 4.4 59.6 1 K.SPWSMDENLMHISYEAGILENPK.N1 6.44031 4.4 55.6 1 K.TQDPAKAPNSPDVLEIEFK.K1 7.958879 4.89 51.7 1 K.TQDPAKAPNSPDVLEIEFKK.G

Tax_Id=10090 Gene_Symbol=Gm6998 similar to ribosomal protein S8 isoform 2 Tax_Id=10090 Gene_Symbol=Gm14289;Gm14438 similar to ribosomal protein S8

1 7.188132 4.46 82.6 1 R.LDVGNFSWGSECCTR.K3 4.788437 3.96 82.4 2 K.LTPEEEEILNK.K1 7.853041 4.46 100 1 K.ISSLLEEQFQQGK.L1 6.361469 4.46 93.3 4 R.ADGYVLEGK.E

Tax_Id=10090 Gene_Symbol=Gm5044 hypothetical protein isoform 2 Tax_Id=10090 Gene_Symbol=Gm16477 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm4970 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm5619 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm16375 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm6347 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Rpl7a;Gm8226 60S ribosomal protein L7a

1 5.3949 6.56 88.9 1 K.NFGIGQDIQPK.R1 6.646629 9.08 61.5 1 R.LKVPPAINQFTQALDR.Q1 7.380002 6.56 85.7 1 R.AGVNTVTTLVENK.K

32 6.515301 8.22 41.5 1 R.KTCTTVAFTQVNSEDKGALAK.L1 5.926435 4.46 88 1 K.TCTTVAFTQVNSEDK.G1 10.20986 6.56 68.8 1 K.TCTTVAFTQVNSEDKGALAK.L

Tax_Id=10090 Gene_Symbol=Farp1 Putative uncharacterized protein 1 6.204536 4.46 90.5 1 R.LGAPENSGIST(79.9663)LER.G

55 5.747303 4.12 31.6 2 R.LTCNDTSAALLISHIVQSEIGDFDEALDR.E4 5.452498 4.53 33.1 1 R.LTCNDTSAALLISHIVQSEIGDFDEALDREHLAK.N

Tax_Id=10090 Gene_Symbol=LOC100046735 similar to Serine/arginine repetitive matrix protein 2 1 7.986946 3.64 92.3 1 R.CLELEEMMEEQGYEEQQIQEK.V1 7.638578 3.64 51.7 1 R.CLELEEMMEEQGYEEQQIQEK.V1 7.805557 4.58 75.9 1 K.EETPGQRPVVTETHQLAELNEK.K

27 4.904378 4.58 37.7 1 K.EETPGQRPVVTETHQLAELNEK.KTax_Id=10090 Gene_Symbol=Hist2h2ab;Hist2h2ac Histone H2A type 2-B

1 9.073675 4.14 75.9 1 R.VGAGAPVYMAAVLEYLTAEILELAGNAAR.D1 8.985741 4.14 49.3 2 R.VGAGAPVYMAAVLEYLTAEILELAGNAAR.D

Tax_Id=10090 Gene_Symbol=Mup2;Mup7 major urinary protein 2 precursor Tax_Id=10090 Gene_Symbol=Mup1;Mup13;Mup14;CU041261.1 Major urinary protein 1 Tax_Id=10090 Gene_Symbol=Mup11;Mup1;Mup2;Mup7 major urinary protein 11 Tax_Id=10090 Gene_Symbol=Mup13;Mup14 Novel member of the major urinary protein (Mup) gene family Tax_Id=10090 Gene_Symbol=Mup11 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Mup1 major urinary protein 1 isoform a Tax_Id=10090 Gene_Symbol=Mup10 major urinary protein 10 Tax_Id=10090 Gene_Symbol=Mup2;Mup7 18 kDa protein Tax_Id=10090 Gene_Symbol=CU041261.1 18 kDa protein Tax_Id=10090 Gene_Symbol=Mup9 Major urinary protein 2 Tax_Id=10090 Gene_Symbol=Mup15 similar to major urinary protein 1 Tax_Id=10090 Gene_Symbol=Mup19;Mup1;Mup9;Mup16 Major urinary protein 2 Tax_Id=10090 Gene_Symbol=Mup18 similar to major urinary protein 1 Tax_Id=10090 Gene_Symbol=- Major urinary proteins 11 and 8 (Fragment) Tax_Id=10090 Gene_Symbol=Mup9;CU104690.1;LOC100189605 Major urinary protein 6 Tax_Id=10090 Gene_Symbol=Mup12 similar to major urinary protein 1 Tax_Id=10090 Gene_Symbol=Mup14 similar to major urinary protein 1 Tax_Id=10090 Gene_Symbol=Mup1 major urinary protein 1 isoform b Tax_Id=10090 Gene_Symbol=CU041261.1 Novel member of the major urinary protein (Mup) gene family

1 5.883268 4.58 57.1 1 K.FHTVRDEECSELSMVADK.T1 7.056067 4.25 71.4 1 K.DGETFQLMGLYGREPDLSSDIK.E

14 7.358129 4.25 40.7 1 K.DGETFQLMGLYGREPDLSSDIK.ETax_Id=10090 Gene_Symbol=LOC641192 similar to heat shock protein 70 cognate

1 6.140386 4.46 100 3 K.CNEIISWLDK.N1 6.804804 4.71 60.3 1 K.CNEIISWLDKNQTAEKEEFEHQQK.E1 8.043078 4.89 87 13 K.NQTAEKEEFEHQQK.E

Tax_Id=10090 Gene_Symbol=Prmt5 Protein arginine N-methyltransferase 5 1 7.358369 4.14 92.3 1 R.DLNCVPEIADTLGAVAK.Q

33 7.415211 4.03 30.3 1 K.GYEDYLQSPLQPLMDNLESQTYEVFEKDPIK.Y1 6.815834 4.57 54.7 1 K.CLLDRVPEEEKETNVQVLMVLGAGR.G2 4.048878 4.4 47.5 2 R.VPEEEKETNVQVLMVLGAGR.G1 5.423164 4.12 44 1 K.ADIIVSELLGSFADNELSPECLDGAQHFLK.D1 9.202262 4.14 72.7 1 K.DDGVSIPGEYTSFLAPISSSK.L1 6.688693 4.57 74.1 1 R.EKDRDPEAQFEMPYVVR.L9 5.507656 4.57 50 1 R.EKDRDPEAQFEMPYVVR.L1 6.465232 4.4 84 1 K.DRDPEAQFEMPYVVR.L1 6.115796 4.4 76.2 1 K.DRDPEAQFEMPYVVR.L

Tax_Id=10090 Gene_Symbol=Rpl3 60S ribosomal protein L3

Tax_Id=10090 Gene_Symbol=Rpl3;Gm16468 ribosomal protein L3 Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 1 Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 3 Tax_Id=10090 Gene_Symbol=LOC674810 similar to Ribosomal protein L3 Tax_Id=10090 Gene_Symbol=Gm16468 similar to ribosomal protein L3 isoform 3

1 10.09677 7.25 77.8 1 K.DDASKPVHLTAFLGYK.A1 7.050005 7.25 56.5 1 K.DDASKPVHLTAFLGYK.A1 7.346695 5.8 85 1 K.TVFAEHISDECKR.R1 7.954558 4.25 78.6 2 R.ERLEQQVPVNQVFGQDEMIDVIGVTK.G

11 6.210141 4.25 37.3 1 R.ERLEQQVPVNQVFGQDEMIDVIGVTK.G1 6.3805 4.14 93.8 3 K.NNASTDYDLSDK.S1 7.78947 4.14 90 16 K.NNASTDYDLSDK.S

43 6.710571 4.58 31 1 K.NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLK.GTax_Id=10090 Gene_Symbol=2900073G15Rik Putative uncharacterized protein

1 9.450089 4.58 88.9 1 R.DGFIDKEDLHDMLASMGK.N1 7.697502 4.58 60.4 1 R.DGFIDKEDLHDMLASMGK.N1 5.771833 4.58 54.1 1 R.DGFIDKEDLHDMLASMGK.N1 4.332873 4.03 71.4 1 R.ELLTTMGDRFTDEEVDELYR.E1 5.725149 4.03 52.8 1 R.ELLTTMGDRFTDEEVDELYR.E1 6.686996 3.86 100 1 R.FTDEEVDELYR.E

Tax_Id=10090 Gene_Symbol=Gm7121 similar to insulinoma protein 1 6.574386 6.56 70.3 1 K.KEAPPMEKPEVVK.T1 5.394371 4.72 75 1 K.EAPPMEKPEVVK.T1 8.156544 4.46 68.8 3 R.DMIILPEMVGSMVGVYNGK.T

Tax_Id=10090 Gene_Symbol=Rpl27;Gm6199;Gm11518 60S ribosomal protein L27 1 4.893031 4.89 67.7 1 K.NIDDGTSDRPYSHALVAGIDR.Y1 7.762155 4.89 44.8 2 K.NIDDGTSDRPYSHALVAGIDR.Y1 8.942692 4.46 86.7 1 R.YSVDIPLDK.T

Tax_Id=10090 Gene_Symbol=Nhp2l1;Gm5616 NHP2-like protein 1 1 7.871075 4.12 48.6 2 R.GISEFIVMAADAEPLEIILHLPLLCEDK.N

Tax_Id=10090 Gene_Symbol=Cyc1 Isoform 1 of Cytochrome c1, heme protein, mitochondrial Tax_Id=10090 Gene_Symbol=Cyc1 Isoform 2 of Cytochrome c1, heme protein, mitochondrial

1 6.158319 4.72 95.2 1 R.HLVGVCYTEEEAK.A1 9.33092 3.69 73.3 1 K.ALAEEVEVQDGPNDDGEMFMR.P1 7.385846 4.03 71.4 1 K.ALAEEVEVQDGPNDDGEMFMRPGK.L1 7.456381 4.03 54 2 K.ALAEEVEVQDGPNDDGEMFMRPGK.L1 6.164966 4.72 44.4 2 R.HGGEDYVFSLLTGYCEPPTGVSLR.E1 5.308325 5.52 87.5 1 R.WASEPEHDHR.K

Tax_Id=10090 Gene_Symbol=Plin2 Adipose differentiation related protein 1 6.26367 4.46 100 1 K.DSVASTVSGVVDK.T1 7.928849 3.8 76.9 2 K.SELLVDQYFPLTQEELEMEAK.K

Tax_Id=10090 Gene_Symbol=Wdr77 18 kDa protein 5 7.196183 4.72 37.7 2 K.YEHDDIVSTVTVLSSGTQAVSGSK.D1 6.82765 4.14 89.5 2 K.DSVFLSCSEDSR.I

Tax_Id=10090 Gene_Symbol=Gm12816 similar to ribosomal protein L3 1 10.09677 7.25 77.8 1 K.DDASKPVHLTAFLGYK.A1 7.050005 7.25 56.5 1 K.DDASKPVHLTAFLGYK.A1 7.954558 4.25 78.6 2 R.ERLEQQVPVNQVFGQDEMIDVIGVTK.G


43 6.710571 4.58 31 1 K.NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLK.GTax_Id=10090 Gene_Symbol=Eif4a1 Eukaryotic initiation factor 4A-I

1 8.468939 3.83 38.4 2 R.SRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLR.G1 8.322711 3.96 100 1 K.MFVLDEADEMLSR.G1 8.789566 4.72 95.8 1 R.DFTVSAMHGDMDQK.E1 9.108422 4.89 80.8 1 R.DFTVSAMHGDMDQKER.D1 6.507654 4.89 64.4 1 R.DFTVSAMHGDMDQKER.D1 5.287485 3.31 53.6 2 R.DIETFYNTSIEEMPLNVADLI.-

Tax_Id=10090 Gene_Symbol=Rpl26 60S ribosomal protein L26 1 4.525352 6.56 100 1 K.FNPFVTSDR.S1 4.501564 4.72 100 6 R.KDDEVQVVR.G1 6.457165 4.89 94.7 4 K.GKYKEETIEKMQE.-1 5.149159 4.89 77.1 5 K.GKYKEETIEKMQE.-

Tax_Id=10090 Gene_Symbol=Rpl12 60S ribosomal protein L12 1 9.287933 4.46 100 1 K.EILGTAQSVGCNVDGR.H1 6.944868 4.4 75 1 R.HPHDIIDDINSGAVECPAS.-

Tax_Id=10090 Gene_Symbol=2310003C23Rik Protein C20orf11 homolog 1 8.630632 3.8 85.2 1 R.MESGIEPSVDLETLDER.I1 6.729815 4.12 56.1 1 R.QRETEAALEFAQTQLAEQGEESR.E

14 4.168863 3.89 36.1 1 R.ETEAALEFAQTQLAEQGEESRECLTEMER.TTax_Id=10090 Gene_Symbol=Glul 22 kDa protein

20 5.097786 4.12 31.3 1 K.CVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFR.D1 4.82671 5.63 92.3 3 R.DIVEAHYR.A

Tax_Id=10090 Gene_Symbol=Thrap3 Thyroid hormone receptor-associated protein 3 1 7.737729 4.42 43.2 2 K.DSRPSQAAGDNQGDEAKEQTFSGGTSQDIK.G1 5.504429 6.56 86.7 1 R.ASVSDLS(79.9663)PR.E3 7.547756 8.59 44.4 1 K.SPVGKS(79.9663)PPATGSAYGSSQKEESAASGGAAYSK.R

14 5.322969 5.02 46.2 1 R.YLEEQKTENGKDKEQK.Q1 7.997669 4.8 80.8 4 K.MADFHKEELDEHDKDK.S1 8.165404 4.8 78.7 6 K.MADFHKEELDEHDKDK.S1 4.500626 4.57 88.9 1 K.GRKEPEFDDEPK.F1 5.487259 4.57 78.8 4 K.GRKEPEFDDEPK.F1 7.927387 4.12 95.2 3 R.KAEEMEDEPFTER.S1 5.43494 4.25 65.6 1 R.MDSFDEDLARPSGLLAQER.K1 5.531497 4.25 85 1 R.SREEEWDPEYTPK.S1 8.054449 4.58 91.7 1 K.YYLHDDREGEGSDK.W1 6.576977 4.16 44.3 1 K.WAHDKFS(79.9663)GEEGEIEDDES(79.9663)GTENREEK.D

Tax_Id=10090 Gene_Symbol=Actn4 23 kDa protein 1 5.265406 5.8 87.5 5 R.HRPELIEYDK.L1 8.237044 4.4 93.1 1 R.KDDPVTNLNNAFEVAEK.Y1 6.458514 4.4 68.9 1 R.KDDPVTNLNNAFEVAEK.Y1 7.763043 4.25 84.6 1 K.MLDAEDIVNTARPDEK.A

Tax_Id=10090 Gene_Symbol=Thrap3 Thyroid hormone receptor associated protein 3 1 7.737729 4.42 43.2 2 K.DSRPSQAAGDNQGDEAKEQTFSGGTSQDIK.G1 5.504429 6.56 86.7 1 R.ASVSDLS(79.9663)PR.E

3 7.547756 8.59 44.4 1 K.SPVGKS(79.9663)PPATGSAYGSSQKEESAASGGAAYSK.R14 5.322969 5.02 46.2 1 R.YLEEQKTENGKDKEQK.Q

1 7.997669 4.8 80.8 4 K.MADFHKEELDEHDKDK.S1 8.165404 4.8 78.7 6 K.MADFHKEELDEHDKDK.S1 4.500626 4.57 88.9 1 K.GRKEPEFDDEPK.F1 5.487259 4.57 78.8 4 K.GRKEPEFDDEPK.F1 7.927387 4.12 95.2 3 R.KAEEMEDEPFTER.S1 5.43494 4.25 65.6 1 R.MDSFDEDLARPSGLLAQER.K

Tax_Id=10090 Gene_Symbol=Atp5j ATP synthase coupling factor VI 1 7.600949 3.96 60 1 R.QASGGPVDIGPEYQQDLDR.E

Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc similar to ubiquitin/40S ribosomal protein S27a fusion protein isoform 2 Tax_Id=10090 Gene_Symbol=Gm8430 similar to fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a

1 9.692141 4.4 83.9 1 R.ECPSDECGAGVFMGSHFDR.H1 7.952041 4.72 67.9 1 C.PSDECGAGVFMGSHFDR.H1 4.29579 4.72 59.1 1 C.PSDECGAGVFMGSHFDR.H1 8.652838 6.23 81.8 1 K.CCLTYCFNKPEDK.-1 5.875928 6.23 70.6 1 K.CCLTYCFNKPEDK.-

Tax_Id=10090 Gene_Symbol=Hadha Trifunctional enzyme subunit alpha, mitochondrial 1 6.064837 4.25 37.7 1 K.VNTLNKEVQSEFIEVMNEIWANDQIR.S1 9.339973 3.86 92.6 1 K.EVQSEFIEVMNEIWANDQIR.S1 4.833557 3.86 53.7 2 K.EVQSEFIEVMNEIWANDQIR.S1 8.504009 4.14 100 2 R.TIEYLEEVAVNFAK.G1 8.931259 4.14 92.3 1 K.AGLEQGSDAGYLAESQK.F1 7.277015 4.46 91.3 1 R.DSIFSNLIGQLDYK.G1 8.338574 4.72 72.4 1 R.DSIFSNLIGQLDYKGFEK.A1 5.97865 3.96 92 2 K.ADMVIEAVFEDLGVK.H1 8.911166 4.42 48.9 1 K.KLDALTTGFGFPVGAATLADEVGVDVAQHVAEDLGK.A1 7.88149 4.42 42.1 2 K.SLNSEMDNILANLRLPAKPEVSSDEDVQYR.V1 9.606128 4.4 92.3 1 R.LPAKPEVSSDEDVQYR.V1 6.326908 4.4 68.2 1 R.LPAKPEVSSDEDVQYR.V

owl|P11021| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN... 2 8.97624 4.28 39.7 1 A.EEEDKKEDVGTVVGIDLGTTYSCVGVFK.N1 5.409415 4.46 94.7 4 R.VEIIANDQGNR.I1 6.206944 4.46 60.9 2 R.ITPSYVAFTPEGER.L1 7.081274 4.46 95.8 1 K.NQLTSNPENTVFDAK.R1 6.592686 4.72 100 1 R.AKFEELNMDLFR.S1 7.431835 4.42 86.7 2 K.VLEDSDLKKSDIDEIVLVGGSTR.I2 5.898348 4.12 53.2 1 K.IEWLESHQDADIEDFK.A1 10.06747 4.42 85.7 1 K.IEWLESHQDADIEDFKAK.K6 4.953679 4.42 49 1 K.IEWLESHQDADIEDFKAK.K1 5.149179 4.14 94.7 1 K.ELEEIVQPIISK.L

Tax_Id=10090 Gene_Symbol=Rpl22;mCG_130059 60S ribosomal protein L22 Tax_Id=10090 Gene_Symbol=Gm6784;LOC632026 similar to ribosomal protein L22

1 7.994573 4.12 71.4 2 K.FTLDCTHPVEDGIMDAANFEQFLQER.I1 8.868443 4.12 49.3 2 K.FTLDCTHPVEDGIMDAANFEQFLQER.I

Tax_Id=10090 Gene_Symbol=Rps3 40S ribosomal protein S3 1 6.073593 4.46 93.3 1 K.AELNEFLTR.E1 8.067074 4.14 91.3 1 R.FGFPEGSVELYAEK.V

29 5.675801 5 34.8 1 K.KPLPDHVSIVEPKDEILPTT(79.9663)PISEQK.G1 5.030452 4.14 86.4 2 K.DEILPTTPISEQK.G

no description1 5.166164 6.56 95 1 R.FLEQQNQVLQTK.W1 8.028638 5.63 84 2 R.THNLEPYFESFINNLR.R1 5.861235 4.73 53.1 1 K.NMQDMVEDYRNKYEDEINKR.T1 5.232953 6.56 81.2 1 R.NKYEDEINKR.T3 5.401463 6.56 75 2 R.NKYEDEINKR.T1 6.95813 4.46 88.9 2 R.TNAENEFVTIK.K1 7.30665 6.56 94.7 1 R.TNAENEFVTIKK.D1 6.906163 4.46 93.3 4 K.DVDGAYMTK.V1 8.226635 4.89 58.9 1 K.SKAEAESLYQSKYEELQITAGR.H1 8.611511 4.46 95.8 1 K.QISNLQQSISDAEQR.G1 6.264318 4.72 82.1 1 K.NKLNDLEDALQQAK.E1 7.057441 4.14 95 1 K.LNDLEDALQQAK.E1 5.674906 4.46 92.9 1 R.DYQELMNTK.L

Tax_Id=10090 Gene_Symbol=Rpl10;LOC100048223;LOC100048462;Gm10041;Gm13891 60S ribosomal protein L10 Tax_Id=10090 Gene_Symbol=Rpl10 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gm3405 similar to QM protein Tax_Id=10090 Gene_Symbol=Rpl10 23 kDa protein

1 8.151094 4.28 52.1 1 K.AKVDEFPLCGHMVSDEYEQLSSEALEAAR.I1 7.208552 4.03 80.8 2 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I1 6.748696 4.03 47.1 2 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I

57 5.010604 4.03 31.9 1 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I1 5.662869 3.86 95.5 1 K.FNADEFEDMVAEK.R1 8.695766 4.25 87.5 1 K.FNADEFEDMVAEKR.L1 5.346152 4.25 59.5 1 K.FNADEFEDMVAEKR.L

Tax_Id=10090 Gene_Symbol=Myh9 Putative uncharacterized protein 1 8.519996 4.4 72.4 1 K.VEDMAELTCLNEASVLHNLK.E1 8.416608 4.14 100 1 K.NLPIYSEEIVEMYK.G1 7.822263 4.4 82.8 1 R.SMMQDREDQSILCTGESGAGK.T1 3.994156 4.4 55.6 1 R.SMMQDREDQSILCTGESGAGK.T

Tax_Id=10090 Gene_Symbol=Hnrnpu Heterogeneous nuclear ribonucleoprotein U 1 3.900911 4.72 100 5 K.VSELKEELK.K2 6.149959 4.25 39.2 2 R.LQAALDNEAGGRPAMEPGNGSLDLGGDAAGR.S1 7.095376 4.14 93.8 1 R.GYFEYIEENK.Y1 6.81282 4.72 95 1 R.GYFEYIEENKYSR.A1 5.810762 4.72 77.1 1 R.GYFEYIEENKYSR.A7 6.524446 4.31 32.1 3 R.AKS(79.9663)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK.I1 5.605329 4.25 51.9 1 K.EKPYFPIPEDCTFIQNVPLEDR.V1 6.379815 4.25 49.2 1 K.EKPYFPIPEDCTFIQNVPLEDR.V1 5.895058 6.56 100 1 R.NFILDQTNVSAAAQR.R1 10.23283 3.86 67.9 3 K.GNFTLPEVAECFDEITYVELQK.E1 6.263826 3.86 45.9 2 K.GNFTLPEVAECFDEITYVELQK.E1 6.169364 4.03 65.4 2 K.GNFTLPEVAECFDEITYVELQKEEAQK.L1 5.606988 4.72 100 2 K.LLEQYKEESK.K

Tax_Id=10090 Gene_Symbol=Ddx3x ATP-dependent RNA helicase DDX3X 1 6.289434 6.56 94.4 3 K.DKDAYSSFGSR.G

1 6.684825 4.42 71.4 1 R.WCDKSDEDDWSKPLPPSER.L2 6.396697 4.25 52 1 K.SDEDDWSKPLPPSER.L1 9.439453 4.14 96.4 1 R.LEQELFSGGNTGINFEK.Y1 6.070094 4.14 88.9 1 R.ELAVQIYEEAR.K1 8.15388 4.14 100 3 R.DFLDEYIFLAVGR.V1 7.509368 4.98 50 2 K.KGADSLEDFLYHEGYACTSIHGDR.S1 4.56104 4.98 44.3 3 K.KGADSLEDFLYHEGYACTSIHGDR.S1 4.446549 5.8 93.8 1 R.DREEALHQFR.S4 7.9315 4.84 44.4 1 K.HVINFDLPSDIEEYVHR.I1 5.2378 4.14 100 1 K.DLLDLLVEAK.Q

Tax_Id=10090 Gene_Symbol=Mtdh Protein LYRIC 1 8.890802 3.96 96 1 R.SWQDELAQQAEEGSAR.L

16 5.689828 4.89 39.1 1 R.KTEPSAWTQDTGDTNANGKDWGR.N1 5.188316 4.53 41.4 1 K.SQEPISNDQKVS(79.9663)DDDKEKGEGALPTGK.S

37 4.709105 4.31 34.8 1 K.QGEDNSHTQDTEDLEKDTREELPVNTSK.A1 9.408703 4.4 73.3 2 K.GDSDNSSSQVPPMLQDTDKPK.S

Tax_Id=10090 Gene_Symbol=Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 1 10.62634 3.96 86.7 2 K.VLLASPDLQEAVEEVLPTLK.K1 6.058482 6.56 94.1 1 K.DAVSVFYVSR.T6 4.73331 4.25 38.9 1 R.TSNTNGVDTILDKVDGVSAEPTPESWR.S1 7.930018 4.57 82.1 1 K.YDVEKDEPVRDANGYCIK.V5 6.277265 4.28 33.7 1 R.WKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.I1 7.478607 4.03 43.5 1 K.GENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.I1 6.731943 3.96 94.4 1 K.DTLYFMDDAEK.T

Tax_Id=10090 Gene_Symbol=Tpm4 Tropomyosin alpha-4 chain 1 9.125653 4.4 91.7 1 R.KIQALQQQADDAEDR.A1 6.629818 3.96 95.7 1 K.IQALQQQADDAEDR.A1 4.497397 3.96 100 1 R.IQLLEEELDR.A1 6.366801 3.95 45.7 1 R.IQLLEEELDRAQEQLATALQNLEEAEK.A1 5.602422 4.12 90.5 2 N.LEEAEKAADESER.G

Tax_Id=10090 Gene_Symbol=Rpl22l1 Isoform 1 of 60S ribosomal protein L22-like 1 Tax_Id=10090 Gene_Symbol=Rpl22l1 Isoform 2 of 60S ribosomal protein L22-like 1

1 5.882371 4.58 46.9 1 R.FHLDLTHPVEDGIFDSGNFEQFLR.ETax_Id=10090 Gene_Symbol=Ndufb4;Gm3244;Gm3873 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Tax_Id=10090 Gene_Symbol=Ndufb4 Putative uncharacterized protein

1 6.332535 4.4 44.8 2 K.YKPAPLATLPSTLDPAEYDVSPETR.RTax_Id=10090 Gene_Symbol=Mycbp C-Myc-binding protein Tax_Id=10090 Gene_Symbol=Mycbp Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Mycbp C-myc binding protein

1 5.708319 4.4 60 1 K.VLVALYEEPEKPTSALDFLK.HTax_Id=10090 Gene_Symbol=Hnrnpa3 Isoform 1 of Heterogeneous nuclear ribonucleoprotein A3 Tax_Id=10090 Gene_Symbol=- similar to heterogeneous nuclear ribonucleoprotein A3 Tax_Id=10090 Gene_Symbol=Gm5469 similar to heterogeneous nuclear ribonucleoprotein A3 Tax_Id=10090 Gene_Symbol=Gm9242 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1 Tax_Id=10090 Gene_Symbol=Gm11847 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 13 Tax_Id=10090 Gene_Symbol=Gm9242 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 3 Tax_Id=10090 Gene_Symbol=Gm9242 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 4 Tax_Id=10090 Gene_Symbol=- similar to heterogeneous nuclear ribonucleoprotein A3, isoform 2

Tax_Id=10090 Gene_Symbol=Gm11847 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 12 Tax_Id=10090 Gene_Symbol=Gm6793 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1 Tax_Id=10090 Gene_Symbol=Gm5469 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 7 Tax_Id=10090 Gene_Symbol=Gm6793 EG627828 protein Tax_Id=10090 Gene_Symbol=Gm11847 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 16 Tax_Id=10090 Gene_Symbol=- 33 kDa protein Tax_Id=10090 Gene_Symbol=Gm5469 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1 Tax_Id=10090 Gene_Symbol=Hnrnpa3 Heterogeneous nuclear ribonucleoprotein A3 Tax_Id=10090 Gene_Symbol=Hnrnpa3 Isoform 2 of Heterogeneous nuclear ribonucleoprotein A3

1 6.079035 5 50 7 R.KLFIGGLSFETTDDSLREHFEK.W1 8.721019 4.58 75.9 2 K.LFIGGLSFETTDDSLREHFEK.W1 6.043821 4.89 58.8 2 K.KIFVGGIKEDTEEYNLR.D1 7.84864 4.4 88.5 1 K.IFVGGIKEDTEEYNLR.D1 6.6169 4.42 56.9 2 K.IFVGGIKEDTEEYNLRDYFEK.Y1 6.725139 4.4 90.5 1 K.YGKIETIEVMEDR.Q1 7.237411 3.96 100 2 K.IETIEVMEDR.Q1 7.220628 4.89 80.8 1 K.RGFAFVTFDDHDTVDK.I1 5.889255 4.89 73.8 1 K.RGFAFVTFDDHDTVDK.I1 7.91624 4.4 95.8 1 R.GFAFVTFDDHDTVDK.I1 6.858712 4.4 61.5 1 R.GFAFVTFDDHDTVDK.I

Tax_Id=10090 Gene_Symbol=Rps23 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=LOC100046668;Rps23;Gm15450 40S ribosomal protein S23

1 6.201181 4.25 46.5 1 K.KITAFVPNDGCLNFIEENDEVLVAGFGR.KTax_Id=10090 Gene_Symbol=- similar to ribosomal protein S8 isoform 1

3 4.788437 3.96 82.4 2 K.LTPEEEEILNK.K1 7.853041 4.46 100 1 K.ISSLLEEQFQQGK.L1 6.361469 4.46 93.3 4 R.ADGYVLEGK.E1 7.65671 4.4 88 1 R.ADGYVLEGKELEFYLR.K1 7.294963 4.4 64.4 1 R.ADGYVLEGKELEFYLR.K

Tax_Id=10090 Gene_Symbol=Gm5121 similar to ribosomal protein S8 isoform 1 3 4.788437 3.96 82.4 2 K.LTPEEEEILNK.K1 7.853041 4.46 100 1 K.ISSLLEEQFQQGK.L1 6.361469 4.46 93.3 4 K.ADGYVLEGK.E1 7.65671 4.4 88 1 K.ADGYVLEGKELEFYLR.K1 7.294963 4.4 64.4 1 K.ADGYVLEGKELEFYLR.K

Tax_Id=10090 Gene_Symbol=Cetn2 Centrin-2 Tax_Id=10090 Gene_Symbol=Cetn2 19 kDa protein

1 6.524561 3.67 37 1 K.ELGENLTDEELQEMIDEADRDGDGEVNEQEFLR.ITax_Id=10090 Gene_Symbol=Gm6472;LOC634044 similar to ribosomal protein S7 isoform 1 Tax_Id=10090 Gene_Symbol=Gm9493 similar to ribosomal protein S7

1 10.90664 4.4 83.3 2 R.TLTAVHDAILEDLVFPSEIVGK.R1 4.601679 4.14 75 1 K.LTGKDVNFEFPEFQL.-

Tax_Id=10090 Gene_Symbol=Nme2 Nucleoside diphosphate kinase B 1 6.483158 4.72 95.8 3 R.NIIHGSDSVESAEK.E1 6.346973 4.72 65.9 6 R.NIIHGSDSVESAEK.E1 7.644941 4.8 44.6 6 R.NIIHGSDSVESAEKEIHLWFKPEELIDYK.S

26 6.662412 4.8 33.6 1 R.NIIHGSDSVESAEKEIHLWFKPEELIDYK.S1 4.98367 4.89 55 1 K.EIHLWFKPEELIDYK.S

Tax_Id=10090 Gene_Symbol=Zc3hav1 Putative uncharacterized protein 1 6.365308 3.86 55.2 2 R.MTLEELLGEISLPEAQLYELLK.A1 4.32614 3.86 42.9 1 R.MTLEELLGEISLPEAQLYELLK.A

Tax_Id=10090 Gene_Symbol=Calu Calumenin 2 5.823465 4.42 47.5 1 K.VHNDAQNFDYDHDAFLGAEEAK.S1 6.824978 4.12 95.8 1 K.IDDDKDGFVTVDELK.G1 5.835849 4.42 55.9 3 K.MDKEETKDWILPSDYDHAEAEAR.H

Tax_Id=10090 Gene_Symbol=Gm11353 Ribosomal protein S8 Tax_Id=10090 Gene_Symbol=Rps8 Ribosomal protein S8

1 7.188132 4.46 82.6 1 R.LDVGNFSWGSECCTR.K3 4.788437 3.96 82.4 2 K.LTPEEEEILNK.K1 7.853041 4.46 100 1 K.ISSLLEEQFQQGK.L

Tax_Id=10090 Gene_Symbol=Eno1;LOC100044223;Gm5506 Alpha-enolase Tax_Id=10090 Gene_Symbol=Eno1 Enolase

1 6.883618 4.14 100 3 K.LMIEMDGTENK.S1 7.472912 4.42 47.2 1 K.YGKDATNVGDEGGFAPNILENKEALELLK.T1 7.91605 3.96 70 2 K.DATNVGDEGGFAPNILENK.E1 8.203897 4.89 95.2 1 R.SGKYDLDFKSPDDPSR.Y1 4.979133 4.89 70.7 1 R.SGKYDLDFKSPDDPSR.Y1 5.920916 3.86 67.9 1 K.SFVQNYPVVSIEDPFDQDDWGAWQK.F

39 4.75768 3.86 34.8 1 K.SFVQNYPVVSIEDPFDQDDWGAWQK.FTax_Id=10090 Gene_Symbol=Mina Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Mina 43 kDa protein Tax_Id=10090 Gene_Symbol=Mina 9 kDa protein

1 7.613163 4.25 47.4 1 R.VKEELPETLSVLNFDSPSSFFESLISPIK.VTax_Id=10090 Gene_Symbol=Hnrnpk Isoform 3 of Heterogeneous nuclear ribonucleoprotein K

1 8.726964 4.25 95.5 1 K.RPAEDMEEEQAFK.R1 7.049439 4.57 79.2 1 K.RPAEDMEEEQAFKR.S1 5.027413 4.57 78.9 2 K.RPAEDMEEEQAFKR.S1 7.901464 4.14 82.1 1 R.TDYNASVSVPDSSGPER.I1 4.325107 4.14 92.3 3 R.DYDDMSPR.R1 10.00257 4.42 83.9 1 R.HESGASIKIDEPLEGSEDR.I1 6.736864 3.86 100 12 K.IDEPLEGSEDR.I1 7.094238 4.12 37.5 1 K.IDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVK.Q

Tax_Id=10090 Gene_Symbol=Cltc Clathrin, heavy polypeptide 1 8.842337 3.96 74.1 1 K.SVNESLNNLFITEEDYQALR.T5 6.438036 4.19 37.1 1 K.DAMQYASESKDTELAEELLQWFLQEEKR.E1 7.194625 3.8 88.5 1 K.DTELAEELLQWFLQEEK.R1 8.005528 3.8 64.6 1 K.DTELAEELLQWFLQEEK.R1 7.08519 4.12 60 1 K.DTELAEELLQWFLQEEKR.E

Tax_Id=10090 Gene_Symbol=Ssbp1 Single-stranded DNA-binding protein, mitochondrial Tax_Id=10090 Gene_Symbol=Ssbp1 single-stranded DNA binding protein 1 isoform 1

1 7.5271 4.14 92 1 R.SGDSEVYQMGDVSQK.T1 5.436069 4.14 92.9 1 K.VDYGEYMDK.N1 7.053665 4.72 90.5 1 K.VDYGEYMDKNNVR.R

Tax_Id=10090 Gene_Symbol=Atp5b ATP synthase subunit beta, mitochondrial 1 4.915421 4.14 80 1 R.IMNVIGEPIDER.G5 5.086824 4.25 39.1 1 K.QFAPIHAEAPEFIEMSVEQEILVTGIK.V

1 6.451744 4.4 73.1 1 R.EGNDLYHEMIESGVINLK.D1 8.741643 3.96 92.6 1 R.DQEGQDVLLFIDNIFR.F1 6.651627 3.96 77.8 1 R.DQEGQDVLLFIDNIFR.F1 7.759598 4.12 72.4 2 K.SLQDIIAILGMDELSEEDKLTVSR.A1 5.693914 4.12 49.2 4 K.SLQDIIAILGMDELSEEDKLTVSR.A

Tax_Id=10090 Gene_Symbol=Mettl1 tRNA (guanine-N(7)-)-methyltransferase 1 4.897523 4.25 48.4 3 R.YPVKPEEMDWSELYPEFFAPLIQNK.S1 7.121805 4.28 53.1 1 R.VPLEELSEDPIVEHLGSSTEEGKK.V

Tax_Id=10090 Gene_Symbol=- 47 kDa protein 1 9.739512 4.12 79.3 2 K.EQGYDVIAYLANIGQKEDFEEAR.K1 6.501326 4.12 50.8 1 K.EQGYDVIAYLANIGQKEDFEEAR.K

14 5.370244 4.28 35.1 3 K.KVFIEDVSKEFVEEFIWPAVQSSALYEDR.Y1 7.874978 3.86 78.6 2 K.EFVEEFIWPAVQSSALYEDR.Y1 6.686368 3.86 54.5 1 K.EFVEEFIWPAVQSSALYEDR.Y1 6.30787 4.4 59.6 1 K.SPWSMDENLMHISYEAGILENPK.N

Tax_Id=10090 Gene_Symbol=Arf4 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Arf4 20 kDa protein

1 9.209826 3.96 89.3 1 K.MLLEDELQDAVLLLFANK.Q1 5.406956 4.14 84.6 2 K.QDLPNAMAISEMTDK.L

Tax_Id=10090 Gene_Symbol=Stk38l Isoform 1 of Serine/threonine-protein kinase 38-like Tax_Id=10090 Gene_Symbol=Stk38l Serine/threonine kinase 38 like Tax_Id=10090 Gene_Symbol=Stk38l MCG15023 Tax_Id=10090 Gene_Symbol=Stk38l Isoform 2 of Serine/threonine-protein kinase 38-like

1 9.061385 4.03 100 2 K.KLEVAMEEEGLADEEK.K1 6.609488 4.28 49.1 2 K.KLEVAMEEEGLADEEKK.L1 7.827698 3.69 96 2 K.LEVAMEEEGLADEEK.K1 6.004178 4.14 100 1 R.LGLDDFESLK.V1 9.170904 4.7 48.7 1 K.KDTLTEEETQFYISETVLAIDAIHQLGFIHR.D

57 4.238689 4.42 30.3 1 K.DTLTEEETQFYISETVLAIDAIHQLGFIHR.D11 6.697094 6.56 38.2 1 R.RQLAY(79.9663)STVGTPDYIAPEVFMQTGYNK.L

4 4.261295 4.46 32.1 1 R.QLAYST(79.9663)VGTPDYIAPEVFMQTGYNK.LTax_Id=10090 Gene_Symbol=Eif4a1 eukaryotic translation initiation factor 4A1 isoform 2

1 8.468939 3.83 38.4 2 R.SRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLR.G1 8.322711 3.96 100 1 K.MFVLDEADEMLSR.G1 8.789566 4.72 95.8 1 R.DFTVSAMHGDMDQK.E1 9.108422 4.89 80.8 1 R.DFTVSAMHGDMDQKER.D1 6.507654 4.89 64.4 1 R.DFTVSAMHGDMDQKER.D

Tax_Id=10090 Gene_Symbol=Car3 Carbonic anhydrase 3 1 5.283688 5.63 73.7 1 K.GDNQSPIELHTK.D8 5.280074 5.8 50 1 K.DIKHDPSLQPWSASYDPGSAK.T1 6.209223 4.4 79.2 1 R.EKGEFQILLDALDK.I

no description1 4.880496 4.73 52 1 R.GMQDLVEDFKNKYEDEINKR.T1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T1 9.646843 4.25 89.7 1 R.NLDLDSIIAEVKAQYEEIAQR.S1 7.566906 4.25 58.2 3 R.NLDLDSIIAEVKAQYEEIAQR.S1 5.298876 6.56 94.4 2 R.NTKQEIAEINR.M

1 4.187907 4.72 74.3 1 K.NKLEGLEDALQK.ATax_Id=10090 Gene_Symbol=Opa3 Optic atrophy 3 protein homolog

1 6.110225 4.12 39.5 2 R.LALALEALQAQAQAMPSLSALEELREELQEVR.GTax_Id=10090 Gene_Symbol=Clns1a Methylosome subunit pICln

1 5.442837 5.63 65.4 1 R.DPNAYPQEHLYVMVNAK.L1 7.701669 3.64 62.1 1 R.NYEDGMEVETTPTVAGQFEDADVDH.-

Tax_Id=10090 Gene_Symbol=Eif2ak3 15 kDa protein 3 4.075363 3.8 43.8 1 R.VPAVATAEVTVEDAEALPAAAGEPESR.A

Tax_Id=10090 Gene_Symbol=Dnaja2 DnaJ homolog subfamily A member 2 1 7.241616 3.86 66.7 1 R.ITFTGEADQAPGVEPGDIVLLLQEK.E1 6.136188 3.86 46.6 1 R.ITFTGEADQAPGVEPGDIVLLLQEK.E1 4.958435 4.14 83.3 1 K.FDVQFPENNWINPDK.L1 7.780514 3.83 38.3 1 K.LSELEDLLPSRPEVPNVIGETEEVELQEFDSTR.G

Tax_Id=10090 Gene_Symbol=Pdha1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1 6.200113 7.41 66.7 1 R.YHGHS(79.9663)MSDPGVS(79.9663)YR.T1 7.566329 4.25 83.3 1 R.MVNSNLASVEELKEIDVEVR.K5 5.694622 4.12 34.9 2 R.KEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVR.G

Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 2 Tax_Id=10090 Gene_Symbol=Gm16468 similar to ribosomal protein L3 isoform 2

1 10.09677 7.25 77.8 1 K.DDASKPVHLTAFLGYK.A1 7.050005 7.25 56.5 1 K.DDASKPVHLTAFLGYK.A1 7.346695 5.8 85 1 K.TVFAEHISDECKR.R1 6.3805 4.14 93.8 3 K.NNASTDYDLSDK.S1 7.78947 4.14 90 16 K.NNASTDYDLSDK.S

43 6.710571 4.58 31 1 K.NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLK.GTax_Id=10090 Gene_Symbol=Csda Isoform 1 of DNA-binding protein A Tax_Id=10090 Gene_Symbol=Csda Y-box binding protein (Fragment)

1 9.728408 3.8 92.3 2 R.SVGDGETVEFDVVEGEK.G1 7.088382 3.89 38.6 2 R.SVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSR.Y1 7.83328 4.14 86.2 1 K.GAEAANVTGPDGVPVEGSR.Y2 7.936372 4.89 43.1 1 R.PRPAPAIGEAEDKENQQAANGPNQPSAR.R1 6.854197 4.4 44.3 2 R.PAPAIGEAEDKENQQAANGPNQPSAR.R

Tax_Id=10090 Gene_Symbol=Hnrnpk Putative uncharacterized protein 1 8.726964 4.25 95.5 1 E.RPAEDMEEEQAFK.R1 7.049439 4.57 79.2 1 E.RPAEDMEEEQAFKR.S1 5.027413 4.57 78.9 2 E.RPAEDMEEEQAFKR.S1 7.901464 4.14 82.1 1 R.TDYNASVSVPDSSGPER.I1 4.325107 4.14 92.3 3 R.DYDDMSPR.R1 10.00257 4.42 83.9 1 R.HESGASIKIDEPLEGSEDR.I1 6.736864 3.86 100 12 K.IDEPLEGSEDR.I1 7.094238 4.12 37.5 1 K.IDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVK.S

Tax_Id=10090 Gene_Symbol=Gstp1 Glutathione S-transferase P 1 1 7.437435 4.14 92.6 2 K.FEDGDLTLYQSNAILR.H1 6.596043 4.14 62.7 1 K.FEDGDLTLYQSNAILR.H1 6.712395 4.57 66.1 3 K.NQREAAQMDMVNDGVEDLRGK.Y1 7.107773 3.86 84 3 R.EAAQMDMVNDGVEDLR.G1 6.448991 3.86 80.4 1 R.EAAQMDMVNDGVEDLR.G1 9.417882 4.25 65.5 1 R.EAAQMDMVNDGVEDLRGK.Y

Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase gamma chain

1 6.15924 4.25 47.6 33 R.KPPTFGDASVIALELLNSGYEFDEGSIIFNQFK.STax_Id=10090 Gene_Symbol=Rpl10a 60S ribosomal protein L10a

1 6.172373 5.8 66.7 2 R.DTLYEAVREVLHGNQR.K1 8.066259 4.72 65.5 1 K.MTDDELVYNIHLAVNFLVSLLK.K

Tax_Id=10090 Gene_Symbol=D10Wsu52e 7 kDa protein 1 5.401273 4.14 94.4 1 R.NYNDELQFLDK.I

Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2 Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2

1 7.932013 4.25 88.5 1 K.TDLEKDIISDTSGDFR.K1 5.897157 4.25 63.3 1 K.TDLEKDIISDTSGDFR.K1 5.161139 4.57 87 1 K.TDLEKDIISDTSGDFRK.L1 7.130483 4.12 80 1 R.RAEDGSVIDYELIDQDAR.E1 5.337551 4.12 66.7 1 R.RAEDGSVIDYELIDQDAR.E4 4.940285 4.72 39.1 2 K.GDLENAFLNLVQCIQNKPLYFADR.L

Tax_Id=10090 Gene_Symbol=Psma2 Proteasome subunit alpha type Tax_Id=10090 Gene_Symbol=Psma2 Proteasome subunit alpha type-2

1 6.816559 4.58 57.1 2 K.RYNEDLELEDAIHTAILTLK.E1 10.37686 4.25 86.7 1 R.YNEDLELEDAIHTAILTLK.E1 6.022311 4.25 54.9 1 R.YNEDLELEDAIHTAILTLK.E1 7.335023 3.8 69 2 K.ESFEGQMTEDNIEVGICNEAGFR.R

Tax_Id=10090 Gene_Symbol=- 29 kDa protein Tax_Id=10090 Gene_Symbol=Rps6;Gm13654 40S ribosomal protein S6

1 4.451296 3.96 100 8 K.LIEVDDER.K19 6.928183 4.4 77.8 1 K.LIEVDDERK.L

1 5.062821 6.56 94.7 1 R.KLFNLSKEDDVR.Q1 5.152153 4.72 100 1 K.LFNLSKEDDVR.Q1 5.403587 6.56 100 1 K.KNKEEAAEYAK.L1 4.683478 12 88.9 1 R.RLSS(79.9663)LRAS(79.9663)TSK.S

Tax_Id=10090 Gene_Symbol=Nedd8 NEDD8 1 4.961413 4.12 77.3 1 K.EIEIDIEPTDKVER.I

Tax_Id=10090 Gene_Symbol=Skp1a S-phase kinase-associated protein 1 1 5.145075 3.64 48.4 1 K.TMLEDLGMDDEGDDDPVPLPNVNAAILK.K

Tax_Id=10090 Gene_Symbol=2900073G15Rik 7 kDa protein 1 5.965439 4.46 86.7 1 K.EAFNMIDQNR.D

Tax_Id=10090 Gene_Symbol=D1Pas1 Putative ATP-dependent RNA helicase Pl10 1 6.289434 6.56 94.4 3 K.DKDAYSSFGSR.S1 9.439453 4.14 96.4 1 R.LEQELFSGGNTGINFEK.Y1 6.070094 4.14 88.9 1 R.ELAVQIYEEAR.K1 8.15388 4.14 100 3 R.DFLDEYIFLAVGR.V1 7.509368 4.98 50 2 K.KGADSLEDFLYHEGYACTSIHGDR.S1 4.56104 4.98 44.3 3 K.KGADSLEDFLYHEGYACTSIHGDR.S1 4.446549 5.8 93.8 1 R.DREEALHQFR.S4 7.9315 4.84 44.4 1 K.HVINFDLPSDIEEYVHR.I1 5.2378 4.14 100 1 K.DLLDLLVEAK.Q

Tax_Id=10090 Gene_Symbol=Cox6c Cytochrome c oxidase subunit 6C

Tax_Id=10090 Gene_Symbol=Gm6265 hypothetical protein 1 5.596921 4.89 90 1 R.NYDSMKDFEEMRK.A

Tax_Id=10090 Gene_Symbol=Psmd3 26S proteasome non-ATPase regulatory subunit 3 Tax_Id=10090 Gene_Symbol=Psmd3 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3, isoform CRA_b

1 7.224123 4.19 35.5 2 K.AKPPPGGEQEPPPPAPQDVEMKEEAAAGSGSTGEGDGK.A1 6.705206 4.58 75 1 R.ELDTVTLEDIKEHVR.Q1 5.658857 4.12 67.9 1 R.DFLLPFLEEPMDTEADLQFRPR.T1 6.68598 3.96 95.8 1 K.LQLDSPEDAEFIVAK.A

Tax_Id=10090 Gene_Symbol=Psmc4 26S protease regulatory subunit 6B Tax_Id=10090 Gene_Symbol=Psmc4 proteasome 26S ATPase subunit 4

1 7.652721 4.03 43.4 2 K.IQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSR.Y1 7.152282 4.03 92 1 K.LQQELEFLEVQEEYIKDEQK.N1 5.611623 4.03 57.1 2 K.LQQELEFLEVQEEYIKDEQK.N1 7.811533 4.12 65.5 1 K.MNLSEEVDLEDYVARPDK.I1 5.329759 4.12 58.7 1 K.MNLSEEVDLEDYVARPDK.I

Tax_Id=10090 Gene_Symbol=Myh9 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Myh9 Myh9 protein

1 8.519996 4.4 72.4 1 K.VEDMAELTCLNEASVLHNLK.E1 8.416608 4.14 100 1 K.NLPIYSEEIVEMYK.G

Tax_Id=10090 Gene_Symbol=Prdx4 Putative uncharacterized protein 1 8.882395 4.72 75 1 R.ENECHFYAGGQVYPGEASR.V7 5.524995 4.72 48.1 1 R.ENECHFYAGGQVYPGEASR.V

Tax_Id=10090 Gene_Symbol=Ssb Lupus La protein homolog Tax_Id=10090 Gene_Symbol=Ssb 44 kDa protein Tax_Id=10090 Gene_Symbol=Ssb Putative uncharacterized protein

1 6.737861 4.89 70.4 1 R.SPSRPLPEVTDEYKNDVK.N1 8.100573 4.12 73.1 1 K.GFPTDATLDDIKEWLDDK.G1 7.457218 4.42 42.9 4 K.GFPTDATLDDIKEWLDDKGQILNIQMR.R1 6.850694 4.7 51.7 1 K.FSGDLDDQTCREDLHFLFSNHGEIK.W

Tax_Id=10090 Gene_Symbol=Ptges3;Gm9769;LOC100048119 Prostaglandin E synthase 3 1 8.368888 3.89 57.6 2 K.LNWLSVDFNNWKDWEDDS(79.9663)DEDMSNFDR.F

Tax_Id=10090 Gene_Symbol=Rps21 40S ribosomal protein S21 1 7.982684 4.72 100 1 K.DHASIQMNVAEVDR.T

Tax_Id=10090 Gene_Symbol=Actn4 Alpha-actinin 1 5.125649 4.25 54.9 1 K.AGTQIENIDEDFRDGLK.L1 5.265406 5.8 87.5 5 R.HRPELIEYDK.L1 8.237044 4.4 93.1 1 R.KDDPVTNLNNAFEVAEK.Y1 6.458514 4.4 68.9 1 R.KDDPVTNLNNAFEVAEK.Y1 9.164633 4.25 81.5 1 K.VLAVNQENEHLMEDYER.L2 4.886247 4.25 56.8 1 K.VLAVNQENEHLMEDYER.L1 5.97851 4.14 100 1 R.DYETATLSDIK.A1 10.56102 5.63 88.5 3 R.KHEAFESDLAAHQDR.V

Tax_Id=10090 Gene_Symbol=Hdac1 Histone deacetylase 1 Tax_Id=10090 Gene_Symbol=LOC100046039 similar to histone deacetylase HD1

1 11.7709 4.14 86.7 1 K.SEASGFCYVNDIVLAILELLK.Y3 6.235729 4.57 41.5 1 K.YYAVNYPLRDGIDDESYEAIFKPVMSK.V1 7.866008 4.25 71.4 1 R.DGIDDESYEAIFKPVMSK.V

46 5.869042 4.25 43.8 1 R.DGIDDESYEAIFKPVMSK.V

1 6.431736 4.01 36.6 2 R.MLPHAPGVQMQAIPEDAIPEES(79.9663)GDEDEEDPDKR.ITax_Id=10090 Gene_Symbol=Psmc2 Putative uncharacterized protein

1 6.156816 3.96 60 1 K.ESDTGLAPPALWDLAADK.Q1 8.658166 3.86 64.5 1 K.FVVDLSDQVAPTDIEEGMR.V

18 6.601852 4.28 34.2 1 K.IDPTVTMMQVEEKPDVTYSDVGGCKEQIEK.L1 5.628377 3.96 81.8 4 R.FDDGAGGDNEVQR.T

no description1 5.56328 6.56 100 2 K.VTMQNLNDR.L1 6.356577 3.96 95 1 R.ALEEANADLEVK.I1 9.575151 4.25 89.7 1 R.TDLEMQIEGLKEELAYLR.K1 8.221689 3.96 52.9 1 R.GQTGGDVNVEMDAAPGVDLSR.I1 10.18202 4.4 85.7 1 K.TEELNKEVASNSELVQSSR.S

Tax_Id=10090 Gene_Symbol=Csnk2a1 Casein kinase 2, alpha 1 polypeptide Tax_Id=10090 Gene_Symbol=Csnk2a1 Csnk2a1 protein

1 6.248424 4.12 48.3 1 R.EYWDYESHVVEWGNQDDYQLVR.KTax_Id=10090 Gene_Symbol=Snrpd1 Small nuclear ribonucleoprotein Sm D1 Tax_Id=10090 Gene_Symbol=Gm14277 similar to small nuclear riboprotein Sm-D isoform 2

1 6.195453 3.96 53.3 1 R.YFILPDSLPLDTLLVDVEPK.VTax_Id=10090 Gene_Symbol=Slc27a2 Very long-chain acyl-CoA synthetase

1 6.058482 6.56 94.1 1 K.DAVSVFYVSR.T6 4.73331 4.25 38.9 1 R.TSNTNGVDTILDKVDGVSAEPTPESWR.S1 7.930018 4.57 82.1 1 K.YDVEKDEPVRDANGYCIK.V5 6.277265 4.28 33.7 1 R.WKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.I1 7.478607 4.03 43.5 1 K.GENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.I1 6.731943 3.96 94.4 1 K.DTLYFMDDAEK.T

no description1 5.166164 6.56 95 1 R.FLEQQNQVLQTK.W1 11.8305 3.96 80 1 R.TSQNSELNNMQDLVEDYK.K1 8.89292 4.4 81.5 5 R.TSQNSELNNMQDLVEDYKK.K1 9.646843 4.25 89.7 1 R.NLDLDSIIAEVKAQYEEIAQR.S1 7.566906 4.25 58.2 3 R.NLDLDSIIAEVKAQYEEIAQR.S1 5.839627 4.14 94.7 1 K.NVQDAIADAEQR.G1 8.973569 4.89 96.3 1 K.NVQDAIADAEQRGEHALK.D1 6.800695 4.72 100 1 R.NKLNDLEEALQQAK.E1 4.796722 4.72 83.3 1 R.NKLNDLEEALQQAK.E1 9.46662 4.57 96.7 1 R.NKLNDLEEALQQAKEDLAR.L1 7.058166 4.57 62.3 1 R.NKLNDLEEALQQAKEDLAR.L

26 4.989918 4.57 52.1 1 R.NKLNDLEEALQQAKEDLAR.L1 7.134129 4.14 100 1 K.LNDLEEALQQAK.E1 4.636779 4.25 68.9 1 K.LNDLEEALQQAKEDLAR.L1 4.292123 4.46 92.9 1 R.DYQELMNVK.L1 5.074863 10.06 100 1 K.AAFGGSGGR.G

Tax_Id=10090 Gene_Symbol=Rps19 40S ribosomal protein S19 Tax_Id=10090 Gene_Symbol=Gm4327;Gm8683 hypothetical protein Tax_Id=10090 Gene_Symbol=Rps19 Rps19 protein Tax_Id=10090 Gene_Symbol=Rps19 8 kDa protein Tax_Id=10090 Gene_Symbol=Rps19 15 kDa protein Tax_Id=10090 Gene_Symbol=Rps19 23 kDa protein

Tax_Id=10090 Gene_Symbol=Rps19 19 kDa protein Tax_Id=10090 Gene_Symbol=Gm6636 hypothetical protein

1 5.245039 4.46 93.3 1 K.DVNQQEFVR.A1 6.04101 5.8 66.7 1 K.HKELAPYDENWFYTR.A1 7.645445 4.14 95.2 2 K.ELAPYDENWFYTR.A

Tax_Id=10090 Gene_Symbol=Fmr1 23 kDa protein 1 8.672832 4.25 69 2 K.DVHEDSITVAFENNWQPER.Q1 7.738663 3.86 95.5 1 K.DINESDEVEVYSR.A

Tax_Id=10090 Gene_Symbol=Spna2 Isoform 1 of Spectrin alpha chain, brain Tax_Id=10090 Gene_Symbol=Spna2 Spectrin alpha 2

1 5.221553 3.96 83.3 1 K.VLETAEDIQER.R1 9.188073 4.01 46.9 2 R.ECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK.K1 7.042672 4.58 76 1 K.KFEEFQTDLAAHEER.V1 5.375194 3.86 56.1 1 K.ALINADELANDVAGAEALLDR.H1 7.899552 3.8 83.9 2 K.QEAFLLNEDLGDSLDSVEALLK.K1 9.495851 4.03 70.4 1 R.NVEDIELWLYEVEGHLASDDYGK.D2 6.375448 3.86 93.8 1 R.DVEDEETWIR.E1 8.999676 4.12 61.8 1 R.RQDLEDSLQAQQYFADANEAESWMR.E1 5.582636 4.28 47.5 1 R.EKEPIVGSTDYGKDEDSAEALLK.K9 5.360422 4.12 33.3 1 R.QQVAPMDDETGKELVLALYDYQEK.S1 7.101793 3.96 84 2 K.QVEELYQSLLELGEK.R1 6.594566 4.89 91.7 7 R.LIQSHPESAEDLKEK.C1 5.036813 4.4 93.8 2 K.EKLDILDQER.T1 6.301621 4.14 95 1 R.DCEQAENWMAAR.E1 8.651164 4.12 84.4 1 R.EAFLNTEDKGDSLDSVEALIK.K1 5.343175 4.12 52.7 1 R.EAFLNTEDKGDSLDSVEALIK.K1 6.64964 3.86 93.8 2 R.DVDEIEAWISEK.L2 5.999442 3.86 83.3 1 R.DVDEIEAWISEK.L1 8.80329 3.8 89.7 1 K.DFDFWLSEVEALLASEDYGK.D2 4.518205 4.03 36.2 1 K.DFDFWLSEVEALLASEDYGKDLASVNNLLK.K1 6.029808 3.95 43.3 1 R.GQRLEESLEYQQFVANVEEEEAWINEK.M1 7.122556 3.64 50 1 R.LEESLEYQQFVANVEEEEAWINEK.M1 7.326896 4.25 59.3 1 K.KASAFNSWFENAEEDLTDPVR.C1 9.570733 3.86 78.6 1 K.ASAFNSWFENAEEDLTDPVR.C1 6.513659 4.14 89.7 1 R.SSLSSAQADFNQLAELDR.Q1 8.794413 4.25 93.3 1 K.KIEDLGAAMEEALILDNK.Y1 5.126239 4.25 65.4 1 K.KIEDLGAAMEEALILDNK.Y

Tax_Id=10090 Gene_Symbol=Spnb2 Isoform 2 of Spectrin beta chain, brain 1 1 4.158044 4.25 61 1 R.FQIQDISVETEDNKEK.K1 7.129631 4.12 88 1 K.LLDPEDISVDHPDEK.S1 8.95827 4.58 96 1 K.KHEAIETDIAAYEER.V

12 4.767412 4.53 37.4 1 R.SGHFEQAIKEGEDMIAEEHFGSEK.I1 7.331159 4.12 91.3 2 K.EGEDMIAEEHFGSEK.I1 10.23586 4.28 57.1 3 K.RLEEASLLHQFQADADDIDAWMLDILK.I1 7.988305 4.03 48.5 2 R.LEEASLLHQFQADADDIDAWMLDILK.I4 4.355957 4.53 31.3 1 K.DVAEEITNYRPTIDTLHEQASALPQAHAESPDVK.G1 7.3478 4.58 47.6 2 K.EQWLNNMQIPEKLEDLEVIQHR.F1 6.581081 4.14 95.5 2 R.FESLEPEMNNQASR.V

1 9.117633 4.72 71.4 1 K.DALLSALSIQNYHLECNETK.S1 7.022503 4.71 49 1 K.LSDLQKEAEKLESEHPDQAQAILSR.L1 9.374578 3.96 93.5 1 R.TQTAIASEDMPNTLTEAEK.L

11 4.527737 4.42 47.1 1 K.LLTQHENIKNEIDNYEEDYQK.M1 8.943095 3.96 92.6 1 K.EIEELQSQAQALSQEGK.S1 9.977992 4.84 68.3 2 K.HQILEQAVEDYAETVHQLSK.T1 6.105833 3.86 94.7 1 R.EVDDLEQWIAER.E1 9.434871 4.58 66 1 R.EVVAGSHELGQDYEHVTMLQER.F1 6.441625 3.86 75 1 K.DGLNEAWADLLELIDTR.T2 3.986001 3.86 62.2 3 K.DGLNEAWADLLELIDTR.T

18 4.609024 4.57 60 1 K.EMIDKWEDRWEWLR.LTax_Id=10090 Gene_Symbol=Cdkn2aipnl CDKN2AIP N-terminal-like protein Tax_Id=10090 Gene_Symbol=Cdkn2aipnl 13 kDa protein

1 7.151441 3.86 82.1 2 K.VMEMADGIEVEDLPQFTTR.STax_Id=10090 Gene_Symbol=Sdha Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1 8.597306 4.12 38.6 1 K.GSDWLGDQDAIHYMTEQAPASVVELENYGMPFSR.T29 7.514825 6.51 32.1 1 K.HVNGQDQIVPGLYACGEAACASVHGANR.L36 4.523503 3.96 32.5 2 R.GMVWNTDLVETLELQNLMLCALQTIYGAEAR.K

1 7.720975 4.72 85.7 1 R.VDEYDYSKPIQGQQK.KTax_Id=10090 Gene_Symbol=Dnaja3 Isoform 3 of DnaJ homolog subfamily A member 3, mitochondrial Tax_Id=10090 Gene_Symbol=Dnaja3 Isoform 1 of DnaJ homolog subfamily A member 3, mitochondrial

1 7.675702 3.96 84.6 1 K.FSQLAEAYEVLSDEVK.R1 6.033478 4.4 64.3 1 K.FSQLAEAYEVLSDEVKR.K3 6.829935 4.72 47.5 2 R.DGADIHSDLFISIAQAILGGTAK.A1 5.519248 4.25 37.2 1 R.QQNLILSYAEDETDVEGTVNGVTHTSTGGR.T

Tax_Id=10090 Gene_Symbol=Myl9 Myosin regulatory light polypeptide 9 1 5.965439 4.46 86.7 1 K.EAFNMIDQNR.D1 5.907545 4.58 64.6 1 R.DGFIDKEDLHDMLASLGK.N

Tax_Id=10090 Gene_Symbol=Erh;Gm10131 Enhancer of rudimentary homolog 1 9.367592 3.96 82.1 2 R.TYADYESVNECMEGVCK.M3 5.378797 3.96 52.2 1 R.TYADYESVNECMEGVCK.M

Tax_Id=10090 Gene_Symbol=Echs1 Enoyl-CoA hydratase, mitochondrial 9 6.285866 3.8 31.8 1 K.ALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDK.A1 6.291497 4.14 100 1 K.LVEEAIQCAEK.I

Tax_Id=10090 Gene_Symbol=2700078K21Rik Isoform 1 of Mps one binder kinase activator-like 2 Tax_Id=10090 Gene_Symbol=2700078K21Rik Isoform 2 of Mps one binder kinase activator-like 2

2 6.521447 4.25 34.4 1 K.ETAVMDDLTEVLCSSPGNSGATGDGANSGASGAQNHVK.ETax_Id=10090 Gene_Symbol=- Ig heavy chain V region 7-39

80 4.671022 6.56 43.4 1 K.LS(79.9663)CEASGFTFSNYGMSWVR.QTax_Id=10090 Gene_Symbol=Prdx1 Peroxiredoxin-1

1 7.011422 6.56 100 1 R.LVQAFQFTDK.H1 6.683962 7.11 80 1 K.HGEVCPAGWKPGSDTIKPDVNK.S1 6.528549 7.11 59.7 1 K.HGEVCPAGWKPGSDTIKPDVNK.S

Tax_Id=10090 Gene_Symbol=G3bp2 Isoform B of Ras GTPase-activating protein-binding protein 2 9 5.902732 6.56 40.6 1 K.SAT(79.9663)PPPAEPASLPQEPPKPR.V1 8.50524 4.53 38.8 1 R.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.I6 7.538407 4.53 29.7 1 R.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.I1 8.630968 4.14 77.8 1 K.LPNFGFVVFDDSEPVQR.I

Tax_Id=10090 Gene_Symbol=Spna2 Isoform 2 of Spectrin alpha chain, brain Tax_Id=10090 Gene_Symbol=Spna2 spectrin alpha 2

1 5.221553 3.96 83.3 1 K.VLETAEDIQER.R1 9.188073 4.01 46.9 2 R.ECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK.K1 7.042672 4.58 76 1 K.KFEEFQTDLAAHEER.V1 5.375194 3.86 56.1 1 K.ALINADELANDVAGAEALLDR.H1 7.899552 3.8 83.9 2 K.QEAFLLNEDLGDSLDSVEALLK.K1 9.495851 4.03 70.4 1 R.NVEDIELWLYEVEGHLASDDYGK.D2 6.375448 3.86 93.8 1 R.DVEDEETWIR.E1 8.999676 4.12 61.8 1 R.RQDLEDSLQAQQYFADANEAESWMR.E1 5.582636 4.28 47.5 1 R.EKEPIVGSTDYGKDEDSAEALLK.K9 5.360422 4.12 33.3 1 R.QQVAPMDDETGKELVLALYDYQEK.S1 6.594566 4.89 91.7 7 R.LIQSHPESAEDLKEK.C1 5.036813 4.4 93.8 2 K.EKLDILDQER.T1 6.301621 4.14 95 1 R.DCEQAENWMAAR.E1 8.651164 4.12 84.4 1 R.EAFLNTEDKGDSLDSVEALIK.K1 5.343175 4.12 52.7 1 R.EAFLNTEDKGDSLDSVEALIK.K1 6.64964 3.86 93.8 2 R.DVDEIEAWISEK.L2 5.999442 3.86 83.3 1 R.DVDEIEAWISEK.L1 8.80329 3.8 89.7 1 K.DFDFWLSEVEALLASEDYGK.D2 4.518205 4.03 36.2 1 K.DFDFWLSEVEALLASEDYGKDLASVNNLLK.K1 6.029808 3.95 43.3 1 R.GQRLEESLEYQQFVANVEEEEAWINEK.M1 7.122556 3.64 50 1 R.LEESLEYQQFVANVEEEEAWINEK.M1 7.326896 4.25 59.3 1 K.KASAFNSWFENAEEDLTDPVR.C1 9.570733 3.86 78.6 1 K.ASAFNSWFENAEEDLTDPVR.C1 6.513659 4.14 89.7 1 R.SSLSSAQADFNQLAELDR.Q1 8.794413 4.25 93.3 1 K.KIEDLGAAMEEALILDNK.Y1 5.126239 4.25 65.4 1 K.KIEDLGAAMEEALILDNK.Y

Tax_Id=10090 Gene_Symbol=Rps13;Gm10159;LOC100044992;Gm6573;LOC100048340 40S ribosomal protein S13 Tax_Id=10090 Gene_Symbol=Gm12270 similar to Rps13 protein

1 6.408641 7.33 100 1 R.DSHGVAQVR.F1 7.33146 4.72 70.8 3 K.GLAPDLPEDLYHLIK.K

Tax_Id=10090 Gene_Symbol=Ddx3y ATP-dependent RNA helicase DDX3Y 1 6.289434 6.56 94.4 3 K.DKDAYSSFGSR.D2 6.396697 4.25 52 1 R.SDEDDWSKPLPPSER.L1 9.439453 4.14 96.4 1 R.LEQELFSGGNTGINFEK.Y1 6.070094 4.14 88.9 1 R.ELAVQIYEEAR.K1 8.15388 4.14 100 3 R.DFLDEYIFLAVGR.V1 4.446549 5.8 93.8 1 K.DREEALHQFR.S4 7.9315 4.84 44.4 1 K.HVINFDLPSDIEEYVHR.I1 5.2378 4.14 100 1 K.DLLDLLVEAK.Q

Tax_Id=10090 Gene_Symbol=Gm11230 similar to ribosomal protein 1 5.802982 4.25 95 8 K.RAGELTEDEVER.V4 5.365396 4.25 69.7 1 K.RAGELTEDEVER.V1 5.757286 6.56 85 1 K.YSQVLANGLDNK.L

Tax_Id=10090 Gene_Symbol=Hsp90ab1 9 kDa protein 1 5.866208 4.14 100 1 R.ELISNASDALDK.I

Tax_Id=10090 Gene_Symbol=Thrap3 Thrap3 protein (Fragment)

1 7.997669 4.8 80.8 4 K.MADFHKEELDEHDKDK.S1 8.165404 4.8 78.7 6 K.MADFHKEELDEHDKDK.S1 4.500626 4.57 88.9 1 K.GRKEPEFDDEPK.F1 5.487259 4.57 78.8 4 K.GRKEPEFDDEPK.F1 7.927387 4.12 95.2 3 R.KAEEMEDEPFTER.S1 5.43494 4.25 65.6 1 R.MDSFDEDLARPSGLLAQER.K

Tax_Id=10090 Gene_Symbol=Mccc1 28 kDa protein 1 4.473609 4.4 43.4 1 R.NSMHVDMADEAYSIGPAPSQQSYLAMEK.I1 5.990706 4.72 85 1 K.KSFNDDAMLIEK.F1 5.286065 4.14 100 1 K.SFNDDAMLIEK.F

Tax_Id=10090 Gene_Symbol=Cyb5 Cytochrome b5 Tax_Id=10090 Gene_Symbol=Cyb5 11 kDa protein Tax_Id=10090 Gene_Symbol=Cyb5 12 kDa protein

1 10.05652 4.12 57.6 3 R.EQAGGDATENFEDVGHSTDAR.ETax_Id=10090 Gene_Symbol=Spnb2 Isoform 1 of Spectrin beta chain, brain 1 Tax_Id=10090 Gene_Symbol=Spnb2 MKIAA4049 protein

1 8.04878 3.86 87 1 R.WDVDDWDNENSSAR.L1 4.158044 4.25 61 1 R.FQIQDISVETEDNKEK.K1 7.129631 4.12 88 1 K.LLDPEDISVDHPDEK.S1 8.95827 4.58 96 1 K.KHEAIETDIAAYEER.V

12 4.767412 4.53 37.4 1 R.SGHFEQAIKEGEDMIAEEHFGSEK.I1 7.331159 4.12 91.3 2 K.EGEDMIAEEHFGSEK.I1 10.23586 4.28 57.1 3 K.RLEEASLLHQFQADADDIDAWMLDILK.I1 7.988305 4.03 48.5 2 R.LEEASLLHQFQADADDIDAWMLDILK.I4 4.355957 4.53 31.3 1 K.DVAEEITNYRPTIDTLHEQASALPQAHAESPDVK.G1 7.3478 4.58 47.6 2 K.EQWLNNMQIPEKLEDLEVIQHR.F1 6.581081 4.14 95.5 2 R.FESLEPEMNNQASR.V1 9.117633 4.72 71.4 1 K.DALLSALSIQNYHLECNETK.S1 7.022503 4.71 49 1 K.LSDLQKEAEKLESEHPDQAQAILSR.L1 9.374578 3.96 93.5 1 R.TQTAIASEDMPNTLTEAEK.L

11 4.527737 4.42 47.1 1 K.LLTQHENIKNEIDNYEEDYQK.M1 8.943095 3.96 92.6 1 K.EIEELQSQAQALSQEGK.S1 9.977992 4.84 68.3 2 K.HQILEQAVEDYAETVHQLSK.T1 6.105833 3.86 94.7 1 R.EVDDLEQWIAER.E1 9.434871 4.58 66 1 R.EVVAGSHELGQDYEHVTMLQER.F1 6.441625 3.86 75 1 K.DGLNEAWADLLELIDTR.T2 3.986001 3.86 62.2 3 K.DGLNEAWADLLELIDTR.T

18 4.609024 4.57 60 1 K.EMIDKWEDRWEWLR.LTax_Id=10090 Gene_Symbol=Ndufb9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1 7.049172 4.12 44.9 1 R.EAEEEFWQNQHPQPYIFPDSPGGTSFER.YTax_Id=10090 Gene_Symbol=Glul Glutamine synthetase

20 5.097786 4.12 31.3 1 K.CVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFR.D1 4.82671 5.63 92.3 3 R.DIVEAHYR.A1 7.919165 4.14 87.5 1 R.TCLLNETGDEPFQYK.N1 6.857695 4.14 84 1 R.TCLLNETGDEPFQYKN.-

Tax_Id=10090 Gene_Symbol=Rhoc Rho-related GTP-binding protein RhoC Tax_Id=10090 Gene_Symbol=Gm12844;LOC631743 similar to Rho family GTPase RhoA Tax_Id=10090 Gene_Symbol=Rhoa Transforming protein RhoA

58 6.251598 4.12 31.6 1 R.LRPLSYPDTDVILMCFSIDSPDSLENIPEK.WTax_Id=10090 Gene_Symbol=Rps27l 40S ribosomal protein S27-like Tax_Id=10090 Gene_Symbol=Rps27l 9 kDa protein Tax_Id=10090 Gene_Symbol=Rps27l 12 kDa protein

1 4.601579 4.4 88.9 1 R.DLLHPSLEEEK.K1 3.990299 5.74 85 1 R.DLLHPSLEEEKKK.H

Tax_Id=10090 Gene_Symbol=Gm9846;Rps27 40S ribosomal protein S27 Tax_Id=10090 Gene_Symbol=Gm4180 similar to ribosomal protein S27

1 4.36831 4.4 94.1 1 K.DLLHPSPEEEK.R1 7.511179 5.74 69.4 4 K.DLLHPSPEEEKRK.H

Tax_Id=10090 Gene_Symbol=Acox1 Putative uncharacterized protein 1 9.32176 4.12 76 1 R.EIENLILNDPDFQHEDYNFLTR.S1 6.353046 3.96 78.3 1 R.EFGIADPEEIMWFK.N1 5.082107 4.95 38.5 1 R.GHPEPLDLHLGMFLPTLLHQATEEQQER.F1 6.626176 4.4 48.3 1 R.INESIGQGDLSELPELHALTAGLK.A1 7.128127 4.14 86.4 2 R.YDGNVYENLFEWAK.K

Tax_Id=10090 Gene_Symbol=Acaa2 3-ketoacyl-CoA thiolase, mitochondrial Tax_Id=10090 Gene_Symbol=Acaa2 Acetyl-Coenzyme A acyltransferase 2 (Mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_k

1 8.567999 4.14 100 1 K.DFSATDLTEFAAR.A1 9.133221 3.96 65.8 1 K.DGTVTAGNASGVSDGAGAVIIASEDAVK.K1 7.260284 3.96 80 1 K.DMDLIDVNEAFAPQFLSVQK.A

Tax_Id=10090 Gene_Symbol=Mccc2 Mccc2 protein 1 10.28131 4.25 93.5 2 K.AATGEEVSAEDLGGADLHCR.K1 6.353033 4.25 62.1 2 K.AATGEEVSAEDLGGADLHCR.K1 7.417867 4.72 79.2 1 K.RFEEEGNPYYSSAR.L1 6.231418 3.96 86.4 1 R.LWDDGIIDPVDTR.L

Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase subunit gamma, mitochondrial Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit isoform b

1 6.15924 4.25 47.6 33 R.KPPTFGDASVIALELLNSGYEFDEGSIIFNQFK.S1 6.168426 3.47 72.7 1 K.ELIEIISGAAALD.-

Tax_Id=10090 Gene_Symbol=Rpl26 Ribosomal protein L26 Tax_Id=10090 Gene_Symbol=- 17 kDa protein

1 4.525352 6.56 100 1 K.FNPFVTSDR.S1 6.457165 4.89 94.7 4 K.GKYKEETIEKMQE.-1 5.149159 4.89 77.1 5 K.GKYKEETIEKMQE.-

Tax_Id=10090 Gene_Symbol=LOC100047828;Gm10027 similar to ribosomal protein isoform 1 1 5.895633 5.02 54 1 K.DGKYSQVLANGLDNKLREDLER.L1 5.757286 6.56 85 1 K.YSQVLANGLDNK.L2 5.434835 4.89 55.6 1 K.YSQVLANGLDNKLREDLER.L

13 5.41167 4.89 50 1 K.YSQVLANGLDNKLREDLER.LTax_Id=10090 Gene_Symbol=Ap2b1 Isoform 1 of AP-2 complex subunit beta Tax_Id=10090 Gene_Symbol=Ap2b1 Isoform 2 of AP-2 complex subunit beta

1 6.394936 3.96 71.4 2 K.DVSSLFPDVVNCMQTDNLELK.K2 5.810874 4.14 87.5 1 K.DCEDPNPLIR.A1 7.128848 4.25 48.5 1 R.LASQANIAQVLAELKEYATEVDVDFVR.K1 7.174499 4.12 47.6 1 K.YPNKYESIIATLCENLDSLDEPDAR.A1 8.493976 4.03 50.6 1 R.IDNADELLESFLEGFHDESTQVQLTLLTAIVK.L5 4.549275 4.03 37.5 2 R.IDNADELLESFLEGFHDESTQVQLTLLTAIVK.L

1 7.569104 4.25 44.9 1 K.KPSETQELVQQVLSLATQDSDNPDLR.D10 7.046579 4.42 36.5 1 K.KPSETQELVQQVLSLATQDSDNPDLRDR.G

Tax_Id=10090 Gene_Symbol=Pcna Proliferating cell nuclear antigen Tax_Id=10090 Gene_Symbol=LOC100046823 similar to proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) isoform 2 Tax_Id=10090 Gene_Symbol=LOC100046823 similar to proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) isoform 1 Tax_Id=10090 Gene_Symbol=Pcna Proliferating cell nuclear antigen

1 6.721146 3.86 75 1 R.AEDNADTLALVFEAPNQEK.V1 6.308637 3.86 77.8 1 K.LMDLDVEQLGIPEQEYSCVIK.M

Tax_Id=10090 Gene_Symbol=Psma7 Proteasome subunit alpha type-7 1 9.645297 3.86 92.3 1 K.NYTDDAIETDDLTIK.L4 5.668776 4.31 43.3 1 K.ILNPEEIEKYVAEIEKEKEENEK.K1 8.120958 4.42 83.3 4 K.YVAEIEKEKEENEK.K

Tax_Id=10090 Gene_Symbol=Paip2 Polyadenylate-binding protein-interacting protein 2 1 9.143544 4.03 100 1 R.CFQEMLEEEEEHEWFIPAR.D5 5.185562 4.03 44.9 1 R.CFQEMLEEEEEHEWFIPAR.D

Tax_Id=10090 Gene_Symbol=Dnaja3 Isoform 2 of DnaJ homolog subfamily A member 3, mitochondrial 1 7.675702 3.96 84.6 1 K.FSQLAEAYEVLSDEVK.R1 6.033478 4.4 64.3 1 K.FSQLAEAYEVLSDEVKR.K3 6.829935 4.72 47.5 2 R.DGADIHSDLFISIAQAILGGTAK.A1 5.571378 4.25 42.5 1 R.QQNLILSYAEDETDVEGTVNGVTHTSTGK.R

Tax_Id=10090 Gene_Symbol=Eif2s1 Eukaryotic translation initiation factor 2 subunit 1 1 7.126603 4.58 53.7 7 R.HVAEVLEYTKDEQLESLFQR.T1 6.892331 4.28 41.1 1 K.HAVSDPSILDSLDLNEDEREVLINNINR.R1 6.35033 4.28 42.2 1 K.HAVSDPSILDSLDLNEDEREVLINNINR.R

Tax_Id=10090 Gene_Symbol=Psma1 Proteasome subunit alpha type-1 1 6.830763 4.46 81.8 2 R.NQYDNDVTVWSPQGR.I1 6.049196 3.58 75 1 K.DLEFTIYDDDDVSPFLDGLEER.P2 4.949166 3.89 59.3 2 K.DLEFTIYDDDDVSPFLDGLEERPQR.K

Tax_Id=10090 Gene_Symbol=Gstm1 Glutathione S-transferase, mu 1 1 4.609347 3.96 85.7 1 R.MLLEYTDSSYDEK.R1 7.440577 4.4 95.5 1 R.MLLEYTDSSYDEKR.Y1 4.34949 4.72 80 1 K.RYTMGDAPDFDR.S1 7.550836 4.14 88.9 1 R.YTMGDAPDFDR.S1 7.568022 4.14 94.4 1 R.ADIVENQVMDTR.M

Tax_Id=10090 Gene_Symbol=Rps14 40S ribosomal protein S14 Tax_Id=10090 Gene_Symbol=Rps14 15 kDa protein Tax_Id=10090 Gene_Symbol=Rps14 13 kDa protein

2 5.555347 4.89 47.5 1 K.VKADRDESSPYAAMLAAQDVAQR.C1 10.47267 4.4 90.9 1 K.ADRDESSPYAAMLAAQDVAQR.C1 5.159477 4.4 59.6 1 K.ADRDESSPYAAMLAAQDVAQR.C1 10.88034 4.14 73.3 4 R.DESSPYAAMLAAQDVAQR.C

Tax_Id=10090 Gene_Symbol=Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 1 7.221914 4.28 75 1 K.IPVPEDKYTALVDQEEKEDVK.S1 5.061806 4.28 49.2 1 K.IPVPEDKYTALVDQEEKEDVK.S1 7.560277 4.25 95.8 1 K.YTALVDQEEKEDVK.S

Tax_Id=10090 Gene_Symbol=Fam82a2 Regulator of microtubule dynamics protein 3 1 8.452296 5.63 92.3 1 R.SHS(79.9663)LPNSLDYAQASER.G3 5.556239 5.63 69 1 R.S(79.9663)HSLPNSLDYAQASER.G

1 6.708993 3.96 73.3 2 R.AIPGEAGDAAILPSLSQEGQEK.V1 8.345051 4.25 84.6 1 R.AYSDMSDLTEEESGKK.S1 6.274813 3.96 88.9 1 K.LAQELPDVTNEDSAFQK.D

Tax_Id=10090 Gene_Symbol=Rpl4 60S ribosomal protein L4 2 7.368938 6.56 64.1 1 R.PLISVYSEKGESSGK.N1 6.849373 4.71 65.5 4 K.GHRIEEVPELPLVVEDKVEGYK.K1 4.596705 4.71 48.9 1 K.GHRIEEVPELPLVVEDKVEGYK.K

94 4.297946 5.08 35.3 1 K.GHRIEEVPELPLVVEDKVEGYKK.T1 8.525445 4.12 83.3 1 R.IEEVPELPLVVEDKVEGYK.K1 6.052372 4.42 42 1 R.IEEVPELPLVVEDKVEGYKK.T1 5.206081 6.56 70.8 1 R.RGPCIIYNEDNGIIK.A1 5.457571 4.46 86.4 1 R.GPCIIYNEDNGIIK.A1 5.05908 6.56 100 1 R.KLDELYGTWR.K

Tax_Id=10090 Gene_Symbol=Psmd7 26S proteasome non-ATPase regulatory subunit 7 1 10.71294 4.12 73.3 1 K.DLGLPTEAYISVEEVHDDGTPTSK.T1 8.969564 4.28 52.9 1 K.TFEHVTSEIGAEEAEEVGVEHLLR.D

Tax_Id=10090 Gene_Symbol=Actg1 Actin, gamma, cytoplasmic 1 1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 7.745204 4.72 86.4 1 K.QEYDESGPSIVHR.K1 5.562833 4.72 75 1 K.QEYDESGPSIVHR.K

Tax_Id=10090 Gene_Symbol=Hnrnpf Isoform 1 of Heterogeneous nuclear ribonucleoprotein F Tax_Id=10090 Gene_Symbol=Hnrnpf Isoform 2 of Heterogeneous nuclear ribonucleoprotein F

1 6.324845 3.8 76 4 R.QSGEAFVELESEDDVK.L1 8.953923 5.63 72 1 K.HSGPNSADSANDGFVR.L1 8.067249 4.14 100 1 K.ITGEAFVQFASQELAEK.A1 7.120841 5.63 85.7 1 R.DLSYCLSGMYDHR.Y

Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 1 of Heterogeneous nuclear ribonucleoprotein D0 Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 3 of Heterogeneous nuclear ribonucleoprotein D0

1 5.689414 4.58 61.7 1 K.IDASKNEEDEGHSNSSPR.H1 5.4364 4.14 79.2 1 K.IFVGGLSPDTPEEK.I1 6.136543 4.25 70 1 K.IREYFGGFGEVESIELPMDNK.T1 5.086267 4.25 49.2 1 K.IREYFGGFGEVESIELPMDNK.T1 8.062141 3.86 73.3 4 R.EYFGGFGEVESIELPMDNK.T

Tax_Id=10090 Gene_Symbol=Gm4923 similar to ribosomal protein L27a-like Tax_Id=10090 Gene_Symbol=Rpl27a;Gm7536 ribosomal protein L27a Tax_Id=10090 Gene_Symbol=Gm5908 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm8213 similar to ribosomal protein L27a-like Tax_Id=10090 Gene_Symbol=Gm6378 similar to ribosomal protein L27a-like

1 7.928088 6.56 90 1 R.NQSFCPTVNLDK.L1 6.29258 6.56 71.4 1 R.NQSFCPTVNLDKLWTLVSEQTR.V

Tax_Id=10090 Gene_Symbol=Rplp1 60S acidic ribosomal protein P1 Tax_Id=10090 Gene_Symbol=- similar to acidic ribosomal phosphoprotein P1 isoform 2 Tax_Id=10090 Gene_Symbol=Gm10073 similar to acidic ribosomal phosphoprotein P1 isoform 2 Tax_Id=10090 Gene_Symbol=- similar to acidic ribosomal phosphoprotein P1 isoform 1 Tax_Id=10090 Gene_Symbol=Gm10073 similar to acidic ribosomal phosphoprotein P1 isoform 1 Tax_Id=10090 Gene_Symbol=Gm11942 similar to acidic ribosomal phosphoprotein P1 isoform 1

1 9.521509 3.64 75.9 1 K.KEESEESEDDMGFGLFD.-1 6.30443 3.64 60.7 1 K.KEESEES(79.9663)EDDMGFGLFD.-

1 7.739797 3.64 64 2 K.KEES(79.9663)EES(79.9663)EDDMGFGLFD.-Tax_Id=10090 Gene_Symbol=Dars aspartyl-tRNA synthetase isoform 2

1 6.173244 4.25 85.7 1 R.EIVDAAEDYAKER.YTax_Id=10090 Gene_Symbol=Hdac2 Histone deacetylase 2

1 11.7709 4.14 86.7 1 K.SEASGFCYVNDIVLAILELLK.Y2 7.13057 4.4 51.9 1 R.DGIDDESYGQIFKPIISK.V3 5.705382 4.4 55.6 1 R.DGIDDESYGQIFKPIISK.V

25 4.775047 4.23 31.7 1 R.MLPHAPGVQMQAIPEDAVHEDS(79.9663)GDEDGEDPDKR.ITax_Id=10090 Gene_Symbol=G3bp1 Ras GTPase-activating protein-binding protein 1

1 6.446626 4.14 67.9 1 K.STS(79.9663)PAPADVAPAQEDLR.T1 7.320084 4.14 75.9 1 K.S(79.9663)TSPAPADVAPAQEDLR.T

25 5.406766 5.61 28.1 3 R.HPDSHQLFIGNLPHEVDKSELKDFFQNFGNVVELR.I1 6.168291 4.46 100 2 K.DFFQNFGNVVELR.I1 8.226283 4.14 74.1 2 K.LPNFGFVVFDDSEPVQK.V

Tax_Id=10090 Gene_Symbol=Tpm2 Isoform 1 of Tropomyosin beta chain Tax_Id=10090 Gene_Symbol=Tpm2 Isoform 2 of Tropomyosin beta chain Tax_Id=10090 Gene_Symbol=Tpm2 Tpm2 protein

1 4.942474 4.25 56.5 1 K.GTEDEVEKYSESVK.D1 6.432048 4.4 94.4 2 R.RIQLVEEELDR.A1 4.951957 4.57 64.1 1 R.RIQLVEEELDRAQER.L1 4.633641 3.96 93.8 1 R.IQLVEEELDR.A1 4.781236 4.25 81.8 1 R.IQLVEEELDRAQER.L1 5.602422 4.12 90.5 2 K.LEEAEKAADESER.G

Tax_Id=10090 Gene_Symbol=Calr Calreticulin 2 5.981086 4.12 51.7 7 K.IDNSQVESGSLEDDWDFLPPKK.I1 7.285361 4.42 83.3 1 K.IKDPDAAKPEDWDER.A

41 6.514089 4.31 35.9 1 K.IDDPTDSKPEDWDKPEHIPDPDAK.KTax_Id=10090 Gene_Symbol=Hnrnpul2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 Tax_Id=10090 Gene_Symbol=- similar to heterogeneous nuclear ribonucleoprotein U-like 2

1 5.556764 3.8 42.5 1 R.LQEALDAEMLEDEAGVGGAGPGGACK.A19 5.39822 4.23 27.2 1 R.S(79.9663)KSPPPPEEEAKDEEEDQTLVNLDTYTSDLHFQISK.D

1 7.768429 3.8 76 2 K.EVEGDDVPESIMLEMK.A28 6.087983 4.19 33.3 1 K.ANFSLPEKCDYMDEVTYGELEKEEAQPIVTK.Y

Tax_Id=10090 Gene_Symbol=Gm5978 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein S2 isoform 2 Tax_Id=10090 Gene_Symbol=Gm5921 hypothetical protein isoform 1

1 4.905957 4.72 94.4 1 K.AEDKEWIPVTK.L1 9.916904 4.25 86.7 3 K.ESEIIDFFLGASLKDEVLK.I1 6.655554 5.63 94.4 1 K.SPYQEFTDHLVK.T

Tax_Id=10090 Gene_Symbol=Ddx18 Protein 1 6.501577 4.28 46.4 1 R.GLDIPEVDWIVQYDPPDDPKEYIHR.V

Tax_Id=10090 Gene_Symbol=Ndufb11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial 1 5.194527 4.03 58.5 1 R.QREPTMQWQEDPEPEDENVYAK.N

Tax_Id=10090 Gene_Symbol=- 51 kDa protein 1 8.726964 4.25 95.5 1 K.RPAEDMEEEQAFK.R1 7.049439 4.57 79.2 1 K.RPAEDMEEEQAFKR.S1 5.027413 4.57 78.9 2 K.RPAEDMEEEQAFKR.S1 7.901464 4.14 82.1 1 R.TDYNASVSVPDSSGPER.I

1 4.656957 4.25 21.2 1 K.IIPTLEEGLQLPS(79.9663)PTATSQLPLESDAVECLNYQHYK.GTax_Id=10090 Gene_Symbol=Rps2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Rps2 32 kDa protein Tax_Id=10090 Gene_Symbol=Gm8842 hypothetical protein isoform 2 Tax_Id=10090 Gene_Symbol=LOC639606 hypothetical protein isoform 1

1 4.905957 4.72 94.4 1 K.AEDKEWIPVTK.L5 7.539693 4.28 37.2 6 K.SLEEIYLFSLPIKESEIIDFFLGASLKDEVLK.I1 9.916904 4.25 86.7 3 K.ESEIIDFFLGASLKDEVLK.I

Tax_Id=10090 Gene_Symbol=Vcp Transitional endoplasmic reticulum ATPase Tax_Id=10090 Gene_Symbol=LOC675857 similar to valosin isoform 1

1 7.062067 3.86 88.5 1 R.EAVCIVLSDDTCSDEK.I1 7.224471 4.28 45.2 1 K.LADDVDLEQVANETHGHVGADLAALCSEAALQAIR.K1 5.395182 3.8 64.3 1 R.ETVVEVPQVTWEDIGGLEDVK.R1 8.583917 4.12 70 1 R.ETVVEVPQVTWEDIGGLEDVKR.E1 6.673438 4.4 82.6 1 R.ELQELVQYPVEHPDK.F1 5.264347 4.14 92.9 1 K.DVDLEFLAK.M1 6.692241 3.8 41.9 1 R.QTNPSAMEVEEDDPVPEIR.R

Tax_Id=10090 Gene_Symbol=Psmd4 21 kDa protein 1 7.633557 4.12 66.7 1 R.AAAASAAEAGIATPGTEGERDSDDALLK.M2 5.077818 4.12 40.5 1 R.AAAASAAEAGIATPGTEGERDSDDALLK.M

Tax_Id=10090 Gene_Symbol=Calu calumenin isoform 2 2 5.823465 4.42 47.5 1 K.VHNDAQNFDYDHDAFLGAEEAK.S1 5.835849 4.42 55.9 3 K.MDKEETKDWILPSDYDHAEAEAR.H

Tax_Id=10090 Gene_Symbol=LOC630401 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 5 Tax_Id=10090 Gene_Symbol=LOC630401 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 6 Tax_Id=10090 Gene_Symbol=LOC630401 similar to heterogeneous nuclear ribonucleoprotein A3, isoform 1

1 6.079035 5 50 7 R.KLFIGGLSFETTDDSLREHFEK.W1 8.721019 4.58 75.9 2 K.LFIGGLSFETTDDSLREHFEK.W1 6.725139 4.4 90.5 1 K.YGKIETIEVMEDR.Q1 7.237411 3.96 100 2 K.IETIEVMEDR.Q1 7.220628 4.89 80.8 1 K.RGFAFVTFDDHDTVDK.I1 5.889255 4.89 73.8 1 K.RGFAFVTFDDHDTVDK.I1 7.91624 4.4 95.8 1 R.GFAFVTFDDHDTVDK.I1 6.858712 4.4 61.5 1 R.GFAFVTFDDHDTVDK.I

Tax_Id=10090 Gene_Symbol=Pgrmc2 Membrane-associated progesterone receptor component 2 1 6.343666 4.19 44.2 1 R.GLATFCLDKDALRDEYDDLSDLNAVQMESVR.E

Tax_Id=10090 Gene_Symbol=Wibg Isoform 1 of Partner of Y14 and mago Tax_Id=10090 Gene_Symbol=Wibg Isoform 2 of Partner of Y14 and mago

1 6.595889 3.96 66.7 2 K.EGYVPQEEVPVYENK.Y1 5.859811 3.8 75 1 R.RVLEEELEDLELGL.-1 7.373963 3.23 90 1 R.VLEEELEDLELGL.-

Tax_Id=10090 Gene_Symbol=Spnb2 11 kDa protein 1 8.04878 3.86 87 1 R.WDVDDWDNENSSAR.L

Tax_Id=10090 Gene_Symbol=Mina Myc-induced nuclear antigen 1 7.613163 4.25 47.4 1 R.VKEELPETLSVLNFDSPSSFFESLISPIK.V1 7.086985 4.89 61.1 1 K.DHIVLTVGPDKNPFDEAQQK.V

35 5.443294 4.25 48.9 1 R.QMHMIGEEEESEIFGLR.FTax_Id=10090 Gene_Symbol=Drg1 Developmentally-regulated GTP-binding protein 1

1 8.073946 4.4 70 1 K.DKGGINLTATCPQSELDAETVK.S1 8.358706 3.86 88.5 1 R.SDATADDLIDVVEGNR.V1 10.23223 4.25 100 1 K.DHTLEDEDVIQIVK.K

Tax_Id=10090 Gene_Symbol=Cald1 Protein Tax_Id=10090 Gene_Symbol=Cald1 Protein

1 6.044742 4.4 77.8 1 R.ASGDKEAEGAPQVEAGK.R1 5.26681 4.4 81 1 K.QQEAALELEELKK.K

Tax_Id=10090 Gene_Symbol=Slc27a2 Solute carrier family 27 (Fatty acid transporter), member 2 1 6.058482 6.56 94.1 1 K.DAVSVFYVSR.T6 4.73331 4.25 38.9 1 R.TSNTNGVDTILDKVDGVSAEPTPESWR.S

Tax_Id=10090 Gene_Symbol=Actc1 Actin alpha cardiac 1 5.45591 4.46 100 1 K.AGFAGDDAPR.A

Tax_Id=10090 Gene_Symbol=Csnk2b Casein kinase II subunit beta 41 5.17425 4.28 32.4 1 R.GNEFFCEVDEDYIQDKFNLTGLNEQVPHYR.Q50 4.19149 4.28 31.4 1 R.GNEFFCEVDEDYIQDKFNLTGLNEQVPHYR.Q

Tax_Id=10090 Gene_Symbol=LOC675192;Gm9026 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm15710;Rpl13;Gm12918 60S ribosomal protein L13

2 5.822288 4.46 92.3 1 R.GFSLEELR.V1 6.124732 6.56 94.7 2 K.STESLQANVQR.L1 6.727863 4.72 87.5 4 R.VITEEEKNFK.A

Tax_Id=10090 Gene_Symbol=Mup1;Mup2;Mup7;Mup10 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Mup13;Mup14 Novel member of the major urinary protein (Mup) gene family Tax_Id=10090 Gene_Symbol=CU041261.1 Novel member of the major urinary protein (Mup) gene family Tax_Id=10090 Gene_Symbol=Mup13;Mup14 11 kDa protein Tax_Id=10090 Gene_Symbol=Mup13;Mup14 Novel member of the major urinary protein (Mup) gene family Tax_Id=10090 Gene_Symbol=Mup2;Mup7;Mup1 Novel member of the major urinary protein (Mup) gene family Tax_Id=10090 Gene_Symbol=Mup13 major urinary protein 13 Tax_Id=10090 Gene_Symbol=Mup17 similar to major urinary protein 1 Tax_Id=10090 Gene_Symbol=Mup8 major urinary protein 8 Tax_Id=10090 Gene_Symbol=Mup2;Mup7;LOC100048883 major urinary protein 7

1 7.056067 4.25 71.4 1 K.DGETFQLMGLYGREPDLSSDIK.E14 7.358129 4.25 40.7 1 K.DGETFQLMGLYGREPDLSSDIK.E

Tax_Id=10090 Gene_Symbol=Golga3 13 kDa protein 1 11.81892 3.96 96.4 1 R.LPDQQDTAQDASVEVNR.G

Tax_Id=10090 Gene_Symbol=Hsph1 11 kDa protein 1 7.963583 4.14 95 2 R.AGGIETIANEFSDR.C

Tax_Id=10090 Gene_Symbol=Tmed2;Gm10698 Transmembrane emp24 domain-containing protein 2 Tax_Id=10090 Gene_Symbol=Tmed2 Putative uncharacterized protein

1 4.404832 4.42 37.5 1 K.GQDMETEAHQNKLEEMINELAVAMTAVK.HTax_Id=10090 Gene_Symbol=Gm6109 similar to ribosomal protein L30 Tax_Id=10090 Gene_Symbol=Gm6570 similar to ribosomal protein L30 Tax_Id=10090 Gene_Symbol=Gm2648 similar to ribosomal protein L30 Tax_Id=10090 Gene_Symbol=Gm7429 similar to ribosomal protein L30 Tax_Id=10090 Gene_Symbol=Gm6570 similar to ribosomal protein L30 Tax_Id=10090 Gene_Symbol=Rpl30;Gm8808 60S ribosomal protein L30

1 5.181052 4.14 70.8 1 R.VCTLAIIDPGDSDIIR.STax_Id=10090 Gene_Symbol=Akr1a4 Alcohol dehydrogenase [NADP+] Tax_Id=10090 Gene_Symbol=LOC100044692 similar to aldehyde reductase

1 10.25724 4.58 53.6 1 R.HIDCASVYGNETEIGEALKESVGSGK.A1 8.680069 4.25 70 3 R.HPDEPVLLEEPVVLALAEK.H1 4.508988 4.25 58.8 1 R.HPDEPVLLEEPVVLALAEK.H

Tax_Id=10090 Gene_Symbol=Gstt1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gstt1 glutathione S-transferase, theta 1 Tax_Id=10090 Gene_Symbol=Gstt1 26 kDa protein Tax_Id=10090 Gene_Symbol=Gstt1 Glutathione S-transferase theta-1

2 6.898027 3.8 36.1 1 K.VMFPVFLGEQIPPETLAATLAELDVNLQVLEDK.FTax_Id=10090 Gene_Symbol=Hprt Hypoxanthine-guanine phosphoribosyltransferase

27 5.964607 3.95 33.8 1 R.SPSVVISDDEPGYDLDLFCIPNHYAEDLEK.VTax_Id=10090 Gene_Symbol=Rpl19 60S ribosomal protein L19 Tax_Id=10090 Gene_Symbol=Rpl19 ribosomal protein L19 isoform 2 Tax_Id=10090 Gene_Symbol=Gm15360 similar to Mus musculus ribosomal protein L19

1 8.573355 4.72 73.3 2 K.KVWLDPNETNEIANANSR.Q1 5.057903 4.46 100 3 K.LLADQAEAR.R

Tax_Id=10090 Gene_Symbol=LOC100044630;Tomm20;Gm14494 Mitochondrial import receptor subunit TOM20 homolog Tax_Id=10090 Gene_Symbol=Gm15365 similar to Translocase of outer mitochondrial membrane 20 homolog

1 9.17494 3.8 86.7 1 K.FFLEEIQLGEELLAQGDYEK.G1 4.941478 3.8 58.3 2 K.FFLEEIQLGEELLAQGDYEK.G

Tax_Id=10090 Gene_Symbol=Mccc1 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial 1 4.473609 4.4 43.4 1 R.NSMHVDMADEAYSIGPAPSQQSYLAMEK.I1 5.990706 4.72 85 1 K.KSFNDDAMLIEK.F1 5.286065 4.14 100 1 K.SFNDDAMLIEK.F1 6.506928 4.72 61.7 1 K.IPLSQEEIPLQGHAFEAR.I1 6.099893 4.14 93.3 2 R.DGSYDMQIDNK.S1 6.345748 4.14 94.1 5 R.DGSYDMQIDNK.S1 7.415196 4.14 83.3 1 R.VLGDLSSEDGCTYLK.S1 8.931621 4.12 95.5 2 R.HAPLVEFEEEESDK.-

Tax_Id=10090 Gene_Symbol=Rps5 40S ribosomal protein S5 7 5.318247 6.51 36.5 1 K.HAFEIIHLLTGENPLQVLVNAIINSGPR.E

Tax_Id=10090 Gene_Symbol=1200014J11Rik Isoform 3 of Uncharacterized protein C17orf85 homolog Tax_Id=10090 Gene_Symbol=1200014J11Rik Isoform 1 of Uncharacterized protein C17orf85 homolog Tax_Id=10090 Gene_Symbol=1200014J11Rik Isoform 2 of Uncharacterized protein C17orf85 homolog

13 4.733908 3.96 43.8 1 K.AEAPAGPALGLPS(79.9663)PEVESGLER.GTax_Id=10090 Gene_Symbol=Gm4892 similar to QM protein Tax_Id=10090 Gene_Symbol=Rpl10 Ribosomal protein 10 Tax_Id=10090 Gene_Symbol=Rpl10 QM protein (Fragment) Tax_Id=10090 Gene_Symbol=Gm5621 similar to QM protein isoform 2 Tax_Id=10090 Gene_Symbol=Rpl10l 60S ribosomal protein L10-like

1 8.151094 4.28 52.1 1 K.AKVDEFPLCGHMVSDEYEQLSSEALEAAR.I1 7.208552 4.03 80.8 2 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I1 6.748696 4.03 47.1 2 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I

57 5.010604 4.03 31.9 1 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.ITax_Id=10090 Gene_Symbol=Eno1 Enolase

1 6.883618 4.14 100 3 K.LMIEMDGTENK.S1 7.91605 3.96 70 2 K.DATNVGDEGGFAPNILENK.-

Tax_Id=10090 Gene_Symbol=Abcf1 ATP-binding cassette sub-family F member 1 Tax_Id=10090 Gene_Symbol=Abcf1 ATP-binding cassette, sub-family F (GCN20), member 1

4 8.656591 3.86 48.5 2 K.QQPPEPEWIGDGEGTSPADK.V1 5.879139 4.03 58.6 1 K.TFFEELAVEDKQAGEEEK.L1 6.622065 3.86 73.3 2 K.QLSVPASDEEDEVPAPIPR.G1 6.055934 3.51 75 1 K.GGNVFEALIQDDSEEEEEEEENR.V1 8.809199 4.57 59.3 1 R.RLQGQLEQGDDTAAEKLEK.V1 8.171713 4.25 79.3 1 R.LQGQLEQGDDTAAEKLEK.V1 5.216708 3.86 77.3 1 K.NQDEESQEPPELLK.R

Tax_Id=10090 Gene_Symbol=Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 precursor Tax_Id=10090 Gene_Symbol=Ugt2b5 MCG1789

1 6.190502 3.96 56 1 R.DTCLSYSPLLQNMIDEFSDYFLSLCK.D1 7.616625 3.96 49.3 1 R.DTCLSYSPLLQNMIDEFSDYFLSLCK.D1 5.527166 3.96 46.8 1 K.FDVLLSDPVASCGELIAELLQIPFLYSIR.F1 6.727598 3.96 69 1 K.SDVLNALEEVIENPFYK.K1 5.633651 3.96 66 1 K.SDVLNALEEVIENPFYK.K1 8.268647 4.4 82.8 1 K.SDVLNALEEVIENPFYKK.N

Tax_Id=10090 Gene_Symbol=Vim Vimentin 1 5.057958 4.25 68.2 1 R.VEVERDNLAEDIMR.L1 9.942176 3.86 86.2 1 R.EMEENFALEAANYQDTIGR.L1 6.694027 4.4 91.3 1 R.LQDEIQNMKEEMAR.H1 6.312308 4.25 69.6 4 R.DGQVINETSQHHDDLE.-

Tax_Id=10090 Gene_Symbol=Aimp1 small inducible cytokine subfamily E, member 1 3 7.320722 4.42 49.1 4 K.EIEELKQELILAEIHNGVEQVR.V1 5.786956 4.42 55.2 2 K.KHPDADSLYVEEVDVGEAAPR.T

Tax_Id=10090 Gene_Symbol=Uqcrb MCG67985 Tax_Id=10090 Gene_Symbol=Uqcrb Cytochrome b-c1 complex subunit 7

1 5.929357 4.42 73.9 1 R.DDTLHETEDVKEAIR.R24 5.568401 4.42 53.8 1 R.DDTLHETEDVKEAIR.R

Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 1 Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 3

1 10.09677 7.25 77.8 1 K.DDASKPVHLTAFLGYK.A1 7.050005 7.25 56.5 1 K.DDASKPVHLTAFLGYK.A1 7.954558 4.25 78.6 2 R.ERLEQQVPVNQVFGQDEMIDVIGVTK.G


Tax_Id=10090 Gene_Symbol=Eef1a1 21 kDa protein 1 6.833761 4.89 100 1 R.TIEKFEKEAAEMGK.G1 5.732416 4.89 67.6 1 R.TIEKFEKEAAEMGK.G1 5.427823 4.46 77.8 4 K.MDSTEPPYSQK.R

Tax_Id=10090 Gene_Symbol=Mosc1 MOSC domain-containing protein 1, mitochondrial Tax_Id=10090 Gene_Symbol=LOC100045982 similar to MOSC domain-containing protein 1, mitochondrial isoform 1

1 8.750797 4.14 100 1 R.DCGEDAAQWVSSFLK.M1 9.418876 4.25 90 1 R.TKDQVAYSDASPFLVLSEASLEDLNSR.L1 4.851356 4.25 37.3 1 R.TKDQVAYSDASPFLVLSEASLEDLNSR.L

42 5.738032 4.42 37.3 1 R.TKDQVAYSDASPFLVLSEASLEDLNSRLER.RTax_Id=10090 Gene_Symbol=Zc3hav1 Isoform 1 of Zinc finger CCCH-type antiviral protein 1

1 6.365308 3.86 55.2 2 R.MTLEELLGEISLPEAQLYELLK.A1 4.32614 3.86 42.9 1 R.MTLEELLGEISLPEAQLYELLK.A

17 6.629286 4.25 35.2 1 K.NHELSGLNQEELAVLLVQSDPFFMPEICK.S1 6.897825 3.86 92 2 R.ASQEFLEDGDPDGLFSR.N1 6.75282 3.96 88.5 2 R.WQLFILPTWMDFQDMEYIER.A1 6.829831 3.8 64 1 R.NASTVSSNEYEFIELNNQDEEYAK.I

11 4.356682 3.8 40 1 R.NASTVSSNEYEFIELNNQDEEYAK.I1 8.583179 3.86 88 1 K.EQIYPEYVIEYMELEK.E1 5.480482 3.86 78.6 1 K.EQIYPEYVIEYMELEK.E1 7.557217 4.12 88.5 1 K.EQIYPEYVIEYMELEKEK.G

Tax_Id=10090 Gene_Symbol=Exosc7 Exosome complex exonuclease RRP42 Tax_Id=10090 Gene_Symbol=Exosc7 MCG23310, isoform CRA_b

1 6.792175 3.89 71.4 1 R.VLEDEEGAKDIELSDDPYDCIR.L1 6.586726 3.89 54.1 1 R.VLEDEEGAKDIELSDDPYDCIR.L1 5.974027 3.96 92 2 K.GSLDPESIFEMMESSK.R

Tax_Id=10090 Gene_Symbol=Esd S-formylglutathione hydrolase 21 4.768249 4.03 24.7 1 K.AYSGSQIDILIDQGKDDEFLSNGQLLPDNFIAACTEK.K

Tax_Id=10090 Gene_Symbol=Mrpl40 39S ribosomal protein L40, mitochondrial Tax_Id=10090 Gene_Symbol=Mrpl40 19 kDa protein

1 7.941895 4.03 44.1 2 R.SMLEAQQEALEELKLESAELYAEAIK.R1 6.677692 4.28 51.5 1 R.SMLEAQQEALEELKLESAELYAEAIKR.D

Tax_Id=10090 Gene_Symbol=Acsl1 16 kDa protein 1 8.632672 4.25 80.8 1 R.SAVLEDDKLLVYYYDDVR.T

Tax_Id=10090 Gene_Symbol=Usp7 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 7 1 9.383821 3.86 96.3 1 K.ENDWGFSNFMAWSEVTDPEK.G3 4.68742 4.12 34.9 1 K.NIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEK.G1 8.24613 4.7 58.9 2 R.CTKEEAIEHNYGGHDDDLSVR.H1 5.37138 3.89 52.1 1 K.ALDELMDGDIIVFQKDDPENDNSELPTAK.E1 5.558877 4.4 95.2 1 R.IQSLLDIQEKEFEK.F1 8.566133 4.4 87.5 1 R.HQYINEDEYEVNLK.D3 5.229021 4.7 36.3 1 R.HQYINEDEYEVNLKDFEPQPGNMSHPR.P

Tax_Id=10090 Gene_Symbol=Actn4 Alpha-actinin-4 1 5.125649 4.25 54.9 1 K.AGTQIENIDEDFRDGLK.L1 5.265406 5.8 87.5 5 R.HRPELIEYDK.L1 8.237044 4.4 93.1 1 R.KDDPVTNLNNAFEVAEK.Y1 6.458514 4.4 68.9 1 R.KDDPVTNLNNAFEVAEK.Y1 7.763043 4.25 84.6 1 K.MLDAEDIVNTARPDEK.A1 9.164633 4.25 81.5 1 K.VLAVNQENEHLMEDYER.L2 4.886247 4.25 56.8 1 K.VLAVNQENEHLMEDYER.L1 5.97851 4.14 100 1 R.DYETATLSDIK.A1 10.56102 5.63 88.5 3 R.KHEAFESDLAAHQDR.V1 9.403712 3.96 88 1 R.ETTDTDTADQVIASFK.V

Tax_Id=10090 Gene_Symbol=Sfpq Splicing factor, proline- and glutamine-rich Tax_Id=10090 Gene_Symbol=LOC100045887 similar to PTB-associated splicing factor

1 8.170116 3.96 85.2 2 R.LFVGNLPADITEDEFK.R1 8.48344 3.96 72.4 1 R.NLSPYVSNELLEEAFSQFGPIER.A4 5.43238 3.96 41.3 2 R.NLSPYVSNELLEEAFSQFGPIER.A1 6.220009 3.95 38.8 1 R.CSEGVFLLTTTPRPVIVEPLEQLDDEDGLPEK.L1 9.428707 4.7 92.6 2 K.DKLESEMEDAYHEHQANLLR.Q

Tax_Id=10090 Gene_Symbol=Pabpc4 Poly(A) binding protein, cytoplasmic 4

Tax_Id=10090 Gene_Symbol=- 68 kDa protein Tax_Id=10090 Gene_Symbol=Pabpc4 Poly A binding protein, cytoplasmic 4 Tax_Id=10090 Gene_Symbol=Pabpc4 Poly A binding protein, cytoplasmic 4 Tax_Id=10090 Gene_Symbol=Pabpc4 MCG5546, isoform CRA_c

1 7.352915 4.46 88.9 1 R.SLGYAYVNFQQPADAER.A1 7.844271 4.72 95.8 2 K.GYAFVHFETQEAADK.A1 8.076706 4.89 59.2 1 K.GYAFVHFETQEAADKAIEK.M1 10.52515 4.25 96.4 1 K.NFGEEVDDGNLKELFSQFGK.T1 5.921812 4.25 54.7 1 K.NFGEEVDDGNLKELFSQFGK.T1 9.441607 4.25 92.6 3 K.ITGMLLEIDNSELLHMLESPESLR.S2 6.471026 4.25 44.8 2 K.ITGMLLEIDNSELLHMLESPESLR.S

Tax_Id=10090 Gene_Symbol=Nap1l4 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Nap1l4 Nucleosome assembly protein 1-like 4

1 6.146759 4.4 87.5 1 K.FYEEVHDLER.K1 7.153618 3.86 71.4 1 R.NVDMLSELVQEYDEPILK.H1 8.135446 3.95 43.8 1 K.SEPDKADPFSFEGPEIVDCDGCTIDWK.K

Tax_Id=10090 Gene_Symbol=Ccdc47 Coiled-coil domain containing 47 Tax_Id=10090 Gene_Symbol=Ccdc47 Isoform 3 of Coiled-coil domain-containing protein 47

1 4.381197 4.14 51.7 2 K.DMESLLPLMNMVIYSIDK.ATax_Id=10090 Gene_Symbol=Gm6654 similar to ribosomal protein S26 Tax_Id=10090 Gene_Symbol=Gm7392 similar to ribosomal protein S26, isoform 1 Tax_Id=10090 Gene_Symbol=Gm6654 similar to ribosomal protein S26 Tax_Id=10090 Gene_Symbol=Rps26;LOC100047845 40S ribosomal protein S26

1 5.685002 4.14 76 1 R.DISEASVFDAYVLPK.LTax_Id=10090 Gene_Symbol=Lactb;LOC677144 Serine beta-lactamase-like protein LACTB, mitochondrial

1 6.893195 3.96 87.5 1 K.EVWSEGLGYADVENR.V1 5.274165 4.28 46 1 K.LDLDLPVQHYVPEFPEKEYEGEK.V2 5.262209 4.25 45 1 K.IFHDLDMLTTVQEENEPVIYNR.A1 6.505921 4.4 77.8 1 K.IALEFDKDRAD.-

Tax_Id=10090 Gene_Symbol=Bag2 BAG family molecular chaperone regulator 2 1 7.717726 4.42 54.3 2 R.DAATAVEQEKEILLEMIHSIQNSQDMR.Q

Tax_Id=10090 Gene_Symbol=Rpl23 60S ribosomal protein L23 Tax_Id=10090 Gene_Symbol=LOC100044627 similar to HL23 ribosomal protein

1 7.45271 4.14 69.2 11 K.DGVFLYFEDNAGVIVNNK.GTax_Id=10090 Gene_Symbol=Chd4 50 kDa protein

5 4.738763 4.16 35.4 1 K.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.A51 6.265984 4.16 34.7 1 K.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.A

2 4.893035 4.03 42.9 1 R.LLDRNQDETEDTELQGMNEYLSSFK.V1 8.459036 3.8 75.9 2 R.NQDETEDTELQGMNEYLSSFK.V

Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10C of 26S proteasome non-ATPase regulatory subunit 4 Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10B of 26S proteasome non-ATPase regulatory subunit 4

4 5.931435 4.12 48 1 K.EKVNVDIINFGEEEVNTEK.L1 7.633557 4.12 66.7 1 R.AAAASAAEAGIATPGTEGERDSDDALLK.M2 5.077818 4.12 40.5 1 R.AAAASAAEAGIATPGTEGERDSDDALLK.M

Tax_Id=10090 Gene_Symbol=Hdac2 Putative uncharacterized protein 1 11.7709 4.14 86.7 1 K.SEASGFCYVNDIVLAILELLK.Y2 7.13057 4.4 51.9 1 R.DGIDDESYGQIFKPIISK.V3 5.705382 4.4 55.6 1 R.DGIDDESYGQIFKPIISK.V

Tax_Id=10090 Gene_Symbol=Sfrs3 Isoform Long of Splicing factor, arginine/serine-rich 3 Tax_Id=10090 Gene_Symbol=Gm12355 MCG21910 Tax_Id=10090 Gene_Symbol=LOC100047744;Gm9761 similar to MGC89287 protein Tax_Id=10090 Gene_Symbol=Sfrs3 Isoform Short of Splicing factor, arginine/serine-rich 3

1 7.009878 4.25 70 1 R.NPPGFAFVEFEDPRDAADAVR.ETax_Id=10090 Gene_Symbol=Gm4963 similar to ribosomal protein S25 Tax_Id=10090 Gene_Symbol=Gm2225 similar to ribosomal protein S25 isoform 1 Tax_Id=10090 Gene_Symbol=LOC100045659 similar to hCG1640785 Tax_Id=10090 Gene_Symbol=- similar to hCG1640785 Tax_Id=10090 Gene_Symbol=Gm6029 similar to MGC82151 protein Tax_Id=10090 Gene_Symbol=Gm6988 similar to hCG1640785 Tax_Id=10090 Gene_Symbol=Rps25 40S ribosomal protein S25

1 6.279987 6.56 76.7 1 R.DKLNNLVLFDKATYDK.LTax_Id=10090 Gene_Symbol=Hspd1 Isoform 1 of 60 kDa heat shock protein, mitochondrial

1 8.885373 3.96 45.5 1 K.LVQDVANNTNEEAGDGTTTATVLAR.S1 6.245125 3.96 42.6 2 K.LVQDVANNTNEEAGDGTTTATVLAR.S1 7.335008 3.96 81.8 1 K.TLNDELEIIEGMK.F1 7.660267 4.25 84.6 1 K.TLNDELEIIEGMKFDR.G3 4.997611 4.25 52.1 1 K.TLNDELEIIEGMKFDR.G1 7.528364 4.14 81.8 1 K.CEFQDAYVLLSEK.K1 6.782995 4.12 71.4 1 R.IQEITEQLDITTSEYEKEK.L

Tax_Id=10090 Gene_Symbol=Lrrfip1 Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 2 6.351182 4.03 37 1 R.ASNSPEQSSCLEGLDSEVPGPTEDLKTDLGK.G1 6.94854 4.12 49.4 1 R.GTGGNQREDEVQAGDTTVEDQVGTVASGPAK.Q

Tax_Id=10090 Gene_Symbol=Ndfip1 NEDD4 family-interacting protein 1 Tax_Id=10090 Gene_Symbol=LOC100046168 similar to Nedd4 WW domain-binding protein 5

1 6.715578 4.12 42.9 1 K.TEATIPLVPGRDEDFVGRDDFDDTDQLR.ITax_Id=10090 Gene_Symbol=Akr1a4 Aldo-keto reductase family 1, member A4

1 10.25724 4.58 53.6 1 R.HIDCASVYGNETEIGEALKESVGSGK.ATax_Id=10090 Gene_Symbol=Hnrnpul2 Putative uncharacterized protein

1 5.556764 3.8 42.5 1 R.LQEALDAEMLEDEAGVGGAGPGGACK.ATax_Id=10090 Gene_Symbol=1110004F10Rik Small acidic protein Tax_Id=10090 Gene_Symbol=1110004F10Rik 9 kDa protein

1 8.614577 3.69 71 1 R.SASPDDDLGSSNWEAADLGNEER.KTax_Id=10090 Gene_Symbol=Mgst1 12 kDa protein

1 7.767704 4.46 95.5 1 K.VFANPEDCAGFGK.GTax_Id=10090 Gene_Symbol=D10Ertd641e UPF0448 protein C10orf104 homolog

1 6.91022 3.86 95.5 1 K.LAGLVEELEADEWR.FTax_Id=10090 Gene_Symbol=Usp7 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 7 Tax_Id=10090 Gene_Symbol=Usp7 Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 7

1 9.383821 3.86 96.3 1 E.ENDWGFSNFMAWSEVTDPEK.G3 4.68742 4.12 34.9 1 K.NIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEK.G1 8.24613 4.7 58.9 2 R.CTKEEAIEHNYGGHDDDLSVR.H1 5.37138 3.89 52.1 1 K.ALDELMDGDIIVFQKDDPENDNSELPTAK.E1 5.558877 4.4 95.2 1 R.IQSLLDIQEKEFEK.F1 8.566133 4.4 87.5 1 R.HQYINEDEYEVNLK.D3 5.229021 4.7 36.3 1 R.HQYINEDEYEVNLKDFEPQPGNMSHPR.P

Tax_Id=10090 Gene_Symbol=Hsp90ab1 MCG18238

Tax_Id=10090 Gene_Symbol=Hsp90ab1 Heat shock protein HSP 90-beta 1 5.866208 4.14 100 1 R.ELISNASDALDK.I1 7.424148 3.86 95.8 1 R.NPDDITQEEYGEFYK.S1 4.693698 4.57 47.3 1 K.CLELFSELAEDKENYKK.F1 7.735486 3.96 72 1 R.GFEVVYMTEPIDEYCVQQLK.E1 5.682735 4.4 45.7 1 K.DLVVLLFETALLSSGFSLEDPQTHSNR.I

Tax_Id=10090 Gene_Symbol=Derl2 Isoform 1 of Derlin-2 24 5.063487 4.03 32.5 2 R.TIFDTPDEDPNYNPLPEERPGGFAWGEGQR.L

Tax_Id=10090 Gene_Symbol=Gm6564 similar to QM protein 1 7.208552 4.03 80.8 2 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I1 6.748696 4.03 47.1 2 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.I

57 5.010604 4.03 31.9 1 K.VDEFPLCGHMVSDEYEQLSSEALEAAR.ITax_Id=10090 Gene_Symbol=Sfrs13a Isoform 3 of Splicing factor, arginine/serine-rich 13A Tax_Id=10090 Gene_Symbol=Sfrs13a Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Sfrs13a Isoform 2 of Splicing factor, arginine/serine-rich 13A Tax_Id=10090 Gene_Symbol=Sfrs13a Putative uncharacterized protein

1 6.772596 4.42 54.2 1 R.GFAYVQFEDVRDAEDALHNLDR.K1 6.095003 4.71 50.8 1 R.GFAYVQFEDVRDAEDALHNLDRK.W1 5.457883 4.4 94.1 1 R.DAEDALHNLDR.K

Tax_Id=10090 Gene_Symbol=LOC100047092 similar to Heat shock protein 1 Tax_Id=10090 Gene_Symbol=Hspd1 15 kDa protein Tax_Id=10090 Gene_Symbol=Hspd1 22 kDa protein

1 8.885373 3.96 45.5 1 K.LVQDVANNTNEEAGDGTTTATVLAR.S1 6.245125 3.96 42.6 2 K.LVQDVANNTNEEAGDGTTTATVLAR.S

Tax_Id=10090 Gene_Symbol=Stk38 Putative uncharacterized protein (Fragment) 2 6.371 4.72 61.5 1 K.VTLENFYSNLIAQHEER.E

Tax_Id=10090 Gene_Symbol=Rps20 40S ribosomal protein S20 2 6.461781 5.8 66.7 1 K.DTGKTPVEPEVAIHR.I2 6.201685 5.8 68.3 1 K.DTGKTPVEPEVAIHR.I

Tax_Id=10090 Gene_Symbol=Hnrnpl Heterogeneous nuclear ribonucleoprotein L Tax_Id=10090 Gene_Symbol=Hnrnpl Putative uncharacterized protein

1 8.299521 3.86 74.1 1 R.GLIDGVVEADLVEALQEFGPISYVVVMPK.K1 9.733744 3.86 45.9 2 R.GLIDGVVEADLVEALQEFGPISYVVVMPK.K1 8.56168 3.86 42.6 1 R.GLIDGVVEADLVEALQEFGPISYVVVMPK.K1 5.407742 4.4 45.2 1 K.NDQDTWDYTNPNLSGQGDPGSNPNKR.Q1 11.16988 4.72 80 1 K.SKPGAAMVEMADGYAVDR.A

Tax_Id=10090 Gene_Symbol=Ptbp1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Ptbp1 polypyrimidine tract binding protein 1 isoform 1

29 4.395688 4.72 38.6 1 R.KLPSDVTEGEVISLGLPFGK.V1 8.096987 4.89 63.3 1 R.EGQEDQGLTKDYGSSPLHR.F1 4.61389 4.89 57.1 1 R.EGQEDQGLTKDYGSSPLHR.F1 5.382919 7.33 100 1 K.DYGSSPLHR.F1 4.703752 4.72 44.6 1 K.NFQNIFPPSATLHLSNIPPSVSEDDLK.S

Tax_Id=10090 Gene_Symbol=Plin2 adipose differentiation related protein 1 6.26367 4.46 100 1 K.DSVASTVSGVVDK.T1 7.928849 3.8 76.9 2 K.SELLVDQYFPLTQEELEMEAK.K1 9.520053 4.42 77.8 1 R.SIGYDDTDESHCVEHIESR.T

Tax_Id=10090 Gene_Symbol=Txndc5 Thioredoxin domain-containing protein 5

32 4.610858 3.89 28 1 R.DFETLENWMLQTLNEEPATPEPEAEPPRAPELK.Q1 8.061159 3.86 65.5 1 K.EFPGLSDVTIAEVDCTAER.N

Tax_Id=10090 Gene_Symbol=2810422J05Rik;Gm11808;Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 no descriptionTax_Id=10090 Gene_Symbol=Gm1821 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc 23 kDa protein Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc Ubiquitin B Tax_Id=10090 Gene_Symbol=2810422J05Rik Ubiquitin A-52 residue ribosomal protein fusion product 1 Tax_Id=10090 Gene_Symbol=2810422J05Rik 27 kDa protein Tax_Id=10090 Gene_Symbol=2810422J05Rik 22 kDa protein Tax_Id=10090 Gene_Symbol=Gm11517 similar to ubiquitin A-52 residue ribosomal protein fusion product 1 isoform 1 Tax_Id=10090 Gene_Symbol=Gm7808 similar to ubiquitin A-52 residue ribosomal protein fusion product 1 Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc ubiquitin C Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc;Gm4802;LOC100048105 Ubc protein Tax_Id=10090 Gene_Symbol=Gm13215 similar to fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc Ubiquitin B

1 7.702595 3.96 88 1 K.TITLEVEPSDTIENVK.ATax_Id=10090 Gene_Symbol=Jak1 Tyrosine-protein kinase JAK1 Tax_Id=10090 Gene_Symbol=Jak1 Janus kinase 1

1 6.566537 4.58 44.9 1 K.TEQDGHDIENECLGMAVLAISHYAMMK.K1 10.8714 4.42 93.3 1 R.THIYSGTLLDYKDEEGIAEEK.K1 5.352984 4.42 55.4 1 R.THIYSGTLLDYKDEEGIAEEK.K1 9.037715 4.12 85.7 2 R.DVENIMVEEFVEGGPLDLFMHR.K1 5.384575 4.14 81 2 R.IPWIAPECVEDSK.N1 7.788322 4.25 88.5 1 R.DINKLEEQNPDIVSEK.Q1 5.99008 4.42 44 1 R.DINKLEEQNPDIVSEKQPTTEVDPTHFEK.R1 4.924952 4.63 42.7 1 R.DINKLEEQNPDIVSEKQPTTEVDPTHFEKR.F2 4.276947 3.96 60 1 R.YDPEGDNTGEQVAVK.S1 7.393421 4.57 69 1 K.AIETDKEYYTVKDDR.D

Tax_Id=10090 Gene_Symbol=Morc3 microrchidia 3 1 5.454336 4.57 73.9 1 K.NATEFDFEKDKYDIR.I

13 5.023244 4.57 50 1 K.NATEFDFEKDKYDIR.I1 5.1431 4.14 70.8 1 K.NAEYPVNLPVEDIQK.R1 6.466917 3.95 75 1 R.NCEVPEEPEDEDLVHPTYEK.T1 5.722209 4.23 31.7 1 R.RLSNPPVENSSYKNDDDEDVIILEENSTPKPAVDLEVK.S1 8.16956 3.86 100 2 K.SEVDEMAVQLDDVFR.Q1 5.879794 4.4 90.9 2 R.DQYKNEVQLLEIEK.S

Tax_Id=10090 Gene_Symbol=Sqstm1 Isoform 1 of Sequestosome-1 Tax_Id=10090 Gene_Symbol=Sqstm1 Isoform 2 of Sequestosome-1

1 7.227599 3.96 69.7 2 R.FSFCFSPEPEAEAQAAAGPGPCER.L13 6.785458 4.03 32.9 1 K.IALESVGQPEEQMESGNCS(79.9663)GGDDDWTHLSSK.E

Tax_Id=10090 Gene_Symbol=Ptplad1 Protein tyrosine phosphatase-like protein PTPLAD1 1 6.852893 4.58 60.7 1 K.GDNVYEFHLEFLDLVKPEPAYR.L1 6.463016 4.28 42.6 2 K.RPLFLAPDFDRWLDESDAEMELR.A1 7.150013 3.86 90 1 R.WLDESDAEMELR.A1 5.854661 3.86 75 1 R.WLDES(79.9663)DAEMELR.A

Tax_Id=10090 Gene_Symbol=Gm16409 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=- hypothetical protein isoform 1

1 4.451296 3.96 100 8 K.LIEVDDER.K19 6.928183 4.4 77.8 1 K.LIEVDDERK.L

1 5.403587 6.56 100 1 K.KNKEEAAEYAK.L1 4.683478 12 88.9 1 R.RLSS(79.9663)LRAS(79.9663)TSK.S

Tax_Id=10090 Gene_Symbol=Gm4805 similar to ribosomal protein L26 Tax_Id=10090 Gene_Symbol=Rpl26 Ribosomal protein L26

1 4.525352 6.56 100 1 K.FNPFVTSDR.S1 4.501564 4.72 100 6 Q.KDDEVQVVR.G

Tax_Id=10090 Gene_Symbol=Txn1 Thioredoxin 1 7.806682 4.14 100 1 K.EAFQEALAAAGDK.L

Tax_Id=10090 Gene_Symbol=Gm4978 hypothetical protein 1 7.380002 6.56 85.7 1 Q.AGVNTVTTLVENK.K

32 6.515301 8.22 41.5 1 R.KTCTTVAFTQVNSEDKGALAK.L1 5.926435 4.46 88 1 K.TCTTVAFTQVNSEDK.G1 10.20986 6.56 68.8 1 K.TCTTVAFTQVNSEDKGALAK.L

Tax_Id=10090 Gene_Symbol=Hnrnpab Heterogeneous nuclear ribonucleoprotein A/B Tax_Id=10090 Gene_Symbol=Hnrnpab Hnrpab protein Tax_Id=10090 Gene_Symbol=Hnrnpab heterogeneous nuclear ribonucleoprotein A/B isoform 1

7 5.006816 4.19 33.7 1 K.IFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPK.L1 6.007663 4.25 62.1 2 K.IREYFGQFGEIEAIELPIDPK.L1 6.19054 4.25 47.5 1 K.IREYFGQFGEIEAIELPIDPK.L2 6.427335 3.86 66.7 3 R.EYFGQFGEIEAIELPIDPK.L

13 4.990903 3.86 46.4 2 R.EYFGQFGEIEAIELPIDPK.LTax_Id=10090 Gene_Symbol=Cald1 16 kDa protein

1 6.044742 4.4 77.8 1 R.ASGDKEAEGAPQVEAGK.RTax_Id=10090 Gene_Symbol=Lrrfip1 Isoform 1 of Leucine-rich repeat flightless-interacting protein 1

1 4.593901 4.25 78.9 1 R.EIKDSLAEVEEK.Y1 6.410612 3.86 72.5 2 K.DMLLELEEQLAESQR.Q2 6.351182 4.03 37 1 R.ASNSPEQSSCLEGLDSEVPGPTEDLKTDLGK.G1 6.94854 4.12 49.4 1 R.GTGGNQREDEVQAGDTTVEDQVGTVASGPAK.Q

Tax_Id=10090 Gene_Symbol=Hmgcs2 Hydroxymethylglutaryl-CoA synthase, mitochondrial 1 7.955684 3.86 73.1 4 K.DVGILALEVYFPAQYVDQTDLEK.F4 6.294124 3.86 44.1 1 K.DVGILALEVYFPAQYVDQTDLEK.F1 6.056027 4.14 100 2 R.LEVGTETIIDK.S1 7.928341 4.89 88 1 R.GLKLEETYTNKDVDK.A1 7.920401 4.14 95 2 R.MSPEEFTEIMNQR.E

Tax_Id=10090 Gene_Symbol=Zfp622 Zinc finger protein 622 1 10.40991 3.86 86.7 1 K.LFTDGDAALEFADFYDFR.S3 4.844009 4.12 44.1 1 R.SSYPDYKEGQDPAELEALSTDK.I1 5.848015 3.86 73.1 2 K.ILECDDETMELILPSGAR.V

Tax_Id=10090 Gene_Symbol=Psmc3 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 Tax_Id=10090 Gene_Symbol=Psmc3 Protein Tax_Id=10090 Gene_Symbol=Psmc3 Proteasome (Prosome, macropain) 26S subunit ATPase 3

1 6.430658 3.8 56.6 1 K.MATVWDEAEQDGIGEEVLK.M1 7.605861 3.96 70.8 2 K.DSYLILETLPTEYDSR.V1 9.372992 4.12 80.6 1 K.AMEVDERPTEQYSDIGGLDK.Q7 5.120281 4.12 52.9 1 K.AMEVDERPTEQYSDIGGLDK.Q

Tax_Id=10090 Gene_Symbol=Tuba1a Tubulin alpha-1A chain Tax_Id=10090 Gene_Symbol=Tuba1c Tubulin alpha-1C chain Tax_Id=10090 Gene_Symbol=Tuba1b Tubulin alpha-1B chain

1 9.317764 4.14 66.7 1 K.TIGGGDDSFNTFFSETGAGK.H1 6.601391 3.96 95.7 1 R.AVFVDLEPTVIDEVR.T1 9.820419 4.25 85.7 2 R.AFVHWYVGEGMEEGEFSEAR.E

Tax_Id=10090 Gene_Symbol=Actbl2 Beta-actin-like protein 2 1 6.957728 5.52 46.1 1 R.TTGIVMDSGDGVTHTVPIYEGYALPHAILR.L1 6.187113 4.14 84 2 R.SYELPDGQVITIGNER.F

Tax_Id=10090 Gene_Symbol=LOC100048867 similar to Annexin A2 Tax_Id=10090 Gene_Symbol=Anxa2 Annexin A2

1 7.932013 4.25 88.5 1 K.TDLEKDIISDTSGDFR.K1 5.897157 4.25 63.3 1 K.TDLEKDIISDTSGDFR.K1 5.161139 4.57 87 1 K.TDLEKDIISDTSGDFRK.L1 7.130483 4.12 80 1 R.RAEDGSVIDYELIDQDAR.E1 5.337551 4.12 66.7 1 R.RAEDGSVIDYELIDQDAR.E

Tax_Id=10090 Gene_Symbol=Gsta3 Glutathione S-transferase A3 1 4.510056 4.12 41.4 1 R.ADIALVELLYHVEELDPGVVDNFPLLK.A1 5.794765 4.12 38.9 1 R.ADIALVELLYHVEELDPGVVDNFPLLK.A

Tax_Id=10090 Gene_Symbol=Cfl1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Cfl1 Cofilin-1 Tax_Id=10090 Gene_Symbol=LOC100048522 similar to Cofilin-1

1 9.104436 4.12 93.1 1 K.NIILEEGKEILVGDVGQTVDDPYTTFVK.M3 4.63758 4.12 41.3 1 K.NIILEEGKEILVGDVGQTVDDPYTTFVK.M

Tax_Id=10090 Gene_Symbol=Cps1 Carbamoyl-phosphate synthase [ammonia], mitochondrial 1 9.127857 3.96 95.7 1 K.IEFEGQSVDFVDPNK.Q1 8.087425 4.25 64.3 1 K.IEFEGQSVDFVDPNKQNLIAEVSTK.D

30 6.211952 4.25 37.9 2 K.IEFEGQSVDFVDPNKQNLIAEVSTK.D1 10.09746 4.14 91.7 1 K.VLGTSVESIMATEDR.Q1 6.18574 4.42 40 1 K.VLGTSVESIMATEDRQLFSDKLNEINEK.I1 8.127963 4.14 95.8 2 K.IAPSFAVESMEDALK.A1 8.66831 4.14 85.7 1 K.GLNSDSVTEETLR.K1 7.204567 4.19 38.7 1 K.KTVVVNCNPETVSTDFDECDKLYFEELSLER.I1 6.772341 4.57 62.3 1 K.FVEGAREVEMDAVGKEGR.V1 6.234828 4.95 38.6 1 R.VISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEK.V

16 5.287602 4.95 29.7 1 R.VISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEK.V1 6.751378 4.46 84.6 3 R.DGSIDLVINLPNNNTK.F

Tax_Id=10090 Gene_Symbol=Top1 DNA topoisomerase 1 Tax_Id=10090 Gene_Symbol=Top1 Putative uncharacterized protein

14 6.825253 4.81 40.7 2 R.IKDEPEDDGYFAPPKEDIKPLKR.L8 5.383348 4.81 40.6 1 R.IKDEPEDDGYFAPPKEDIKPLKR.L1 5.01111 4.57 82.9 2 R.LRDEDDADYKPK.K1 6.27868 4.4 85 2 K.WWEEERYPEGIK.W1 9.867483 4.42 62.5 2 R.VEHINLHPELDGQEYVVEFDFPGK.D1 6.751883 4.53 46.6 1 R.VEHINLHPELDGQEYVVEFDFPGKDSIR.Y1 8.255734 4.25 85.2 2 K.NLQLFMENKQPEDDLFDR.L

Tax_Id=10090 Gene_Symbol=Abcd3 ATP-binding cassette sub-family D member 3 Tax_Id=10090 Gene_Symbol=Abcd3 ATP-binding cassette, sub-family D, member 3

8 7.009384 4.4 48.4 1 K.FDHVPLATPNGDILIQDLSFEVR.S1 5.112396 4.4 85.7 6 R.DQVIYPDGKEDQK.K

16 5.113562 4.4 60 1 R.DQVIYPDGKEDQK.K1 6.163079 4.72 87 1 K.EYLDNVQLGHILER.E1 7.784729 3.86 82.8 1 R.EGGWDSVQDWMDVLSGGEK.Q1 5.95806 3.86 57.1 1 R.EGGWDSVQDWMDVLSGGEK.Q1 7.702382 4.14 94.1 1 K.KITEDTVEFGS.-

Tax_Id=10090 Gene_Symbol=Epb4.1l5 Isoform 2 of Band 4.1-like protein 5 Tax_Id=10090 Gene_Symbol=Epb4.1l5 Isoform 3 of Band 4.1-like protein 5 Tax_Id=10090 Gene_Symbol=Epb4.1l5 Isoform 1 of Band 4.1-like protein 5

5 6.359829 4.25 43.5 1 K.GQELFDQIMYHLDLIESDYFGLR.F1 7.537691 3.96 79.2 1 R.FVPIQTEEMELAIFEK.W1 7.667871 3.96 70 1 R.DGNDYSLGLTPTGVLVFEGETK.I

Tax_Id=10090 Gene_Symbol=Rpl8 60S ribosomal protein L8 1 7.291076 4.89 43.2 2 K.KAQLNIGNVLPVGTMPEGTIVCCLEEKPGDR.G

Tax_Id=10090 Gene_Symbol=Pin1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Tax_Id=10090 Gene_Symbol=Pin1l MCG20568

1 9.170718 3.86 69 1 K.SGEEDFESLASQFSDCSSAK.ATax_Id=10090 Gene_Symbol=Psmc1 26S protease regulatory subunit 4

1 7.770502 4.42 63 1 R.NQEQMKPLEEKQEEER.S1 6.50865 4.58 49.1 1 K.ESVELPLTHPEYYEEMGIKPPK.G1 8.11641 4.14 84 2 R.TMLELLNQLDGFDSR.G

Tax_Id=10090 Gene_Symbol=Prdx4 Peroxiredoxin-4 1 8.882395 4.72 75 1 R.ENECHFYAGGQVYPGEASR.V7 5.524995 4.72 48.1 1 R.ENECHFYAGGQVYPGEASR.V1 8.317435 4.72 95.7 1 K.DYGVYLEDSGHTLR.G

Tax_Id=10090 Gene_Symbol=Rps3 21 kDa protein 1 6.073593 4.46 93.3 1 K.AELNEFLTR.E1 8.067074 4.14 91.3 1 R.FGFPEGSVELYAEK.V

Tax_Id=10090 Gene_Symbol=Cisd1 CDGSH iron sulfur domain-containing protein 1 1 8.266534 4.4 100 1 K.VVHAFDMEDLGDK.A

Tax_Id=10090 Gene_Symbol=Mybbp1a Myb-binding protein 1A 14 5.972123 3.86 35.6 1 R.PCYSLALAQLLQSFEDIPLCDILDQIQEK.Y

1 5.639654 3.96 79.3 1 K.ALVDILSEVPESMFQEILPK.V1 7.921159 4.14 70 1 R.DMFLQPDLNSLVDFSTANQK.R

10 7.203441 3.58 34.6 2 K.AGNALGGVDNEEEEELGDEAMMALDQNLASLFK.E1 11.32189 4.03 96.4 1 K.LHGADTEDSEDQAANCLDLDFVTR.V1 7.681874 4.03 63.1 1 K.LHGADTEDSEDQAANCLDLDFVTR.V1 7.047584 3.96 55.6 1 R.VCFEDPEWEQLITQLLGK.A1 6.987885 9.08 77.3 1 K.SPAPSNPTLS(79.9663)PSTPAK.T

Tax_Id=10090 Gene_Symbol=Spna2 Spectrin alpha 2 1 7.326896 4.25 59.3 1 K.KASAFNSWFENAEEDLTDPVR.C1 9.570733 3.86 78.6 1 K.ASAFNSWFENAEEDLTDPVR.C1 6.513659 4.14 89.7 1 R.SSLSSAQADFNQLAELDR.Q1 8.794413 4.25 93.3 1 K.KIEDLGAAMEEALILDNK.Y1 5.126239 4.25 65.4 1 K.KIEDLGAAMEEALILDNK.Y

Tax_Id=10090 Gene_Symbol=Kctd17 Kctd17 protein 1 8.999023 4.03 85.7 2 K.LVLDKDMAEEGVLEEAEFYNIGPLIR.I

6 4.901824 4.03 40.8 1 K.LVLDKDMAEEGVLEEAEFYNIGPLIR.ITax_Id=10090 Gene_Symbol=Mrpl12 39S ribosomal protein L12, mitochondrial

3 5.932446 3.96 42.9 1 K.IQQLVQDIASLTLLEISDLNELLK.K1 7.15889 3.96 44.9 1 K.IQQLVQDIASLTLLEISDLNELLK.K

Tax_Id=10090 Gene_Symbol=Arpc4 Actin-related protein 2/3 complex subunit 4 Tax_Id=10090 Gene_Symbol=Arpc4 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Arpc4 actin related protein 2/3 complex, subunit 4 isoform 3

1 7.266367 4.42 85.2 1 K.LVDFVIHFMEEIDKEISEMK.L1 6.882074 4.42 64.2 1 K.LVDFVIHFMEEIDKEISEMK.L

Tax_Id=10090 Gene_Symbol=Actb Beta-actin FE-3 (Fragment) 1 6.187113 4.14 84 2 -.SYELPDGQVITIGNER.F

Tax_Id=10090 Gene_Symbol=Hist1h2bf;Hist1h2bl;Hist1h2bn;LOC100046213;Hist1h2bj Histone H2B type 1-F/J/L Tax_Id=10090 Gene_Symbol=- 15 kDa protein Tax_Id=10090 Gene_Symbol=- 15 kDa protein Tax_Id=10090 Gene_Symbol=- 14 kDa protein Tax_Id=10090 Gene_Symbol=- 14 kDa protein Tax_Id=10090 Gene_Symbol=Hist1h2bk 15 kDa protein Tax_Id=10090 Gene_Symbol=Hist1h2bh 15 kDa protein Tax_Id=10090 Gene_Symbol=Hist1h2bk 14 kDa protein Tax_Id=10090 Gene_Symbol=- 15 kDa protein Tax_Id=10090 Gene_Symbol=- 15 kDa protein Tax_Id=10090 Gene_Symbol=Hist1h2bm 15 kDa protein Tax_Id=10090 Gene_Symbol=Hist1h2bp Isoform 2 of Histone H2B type 1-P Tax_Id=10090 Gene_Symbol=Hist1h2bp Isoform 1 of Histone H2B type 1-P Tax_Id=10090 Gene_Symbol=Hist1h2bb Histone H2B type 1-B Tax_Id=10090 Gene_Symbol=Hist3h2ba Histone H2B type 3-A Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B Tax_Id=10090 Gene_Symbol=Hist1h2bp 16 kDa protein Tax_Id=10090 Gene_Symbol=Hist2h2bb Histone H2B type 2-B Tax_Id=10090 Gene_Symbol=Hist1h2bm Histone H2B type 1-M Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B type 1-C/E/G Tax_Id=10090 Gene_Symbol=Hist1h2bk Histone H2B type 1-K Tax_Id=10090 Gene_Symbol=Hist3h2bb histone cluster 3, H2bb Tax_Id=10090 Gene_Symbol=Hist1h2bh Histone H2B type 1-H Tax_Id=10090 Gene_Symbol=Hist2h2be Histone H2B type 2-E Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B Tax_Id=10090 Gene_Symbol=Hist2h2bb Hist2h2bb protein

1 9.04351 4.46 95.8 2 K.AMGIMNSFVNDIFER.ITax_Id=10090 Gene_Symbol=Ddx18 ATP-dependent RNA helicase DDX18

1 10.96215 3.86 59.4 2 R.SVPVDSAEAQSGGMPEETLENGK.V4 8.300697 3.95 37.3 2 K.EPLYVGVDDDKEVATVDGLEQGYVVCPSEK.R1 6.501577 4.28 46.4 1 R.GLDIPEVDWIVQYDPPDDPKEYIHR.V

Tax_Id=10090 Gene_Symbol=Sco2 Protein SCO2 homolog, mitochondrial 6 5.362608 4.28 35.6 2 R.KLEAEPDLPLVQPVFITVDPERDDVAAMAR.Y

Tax_Id=10090 Gene_Symbol=Ppil3 Isoform 1 of Peptidyl-prolyl cis-trans isomerase-like 3 6 4.547322 4.12 48 1 K.VIDGLETLDELEKLPVNEK.T

Tax_Id=10090 Gene_Symbol=Ephx2 Isoform 1 of Epoxide hydrolase 2 1 7.83661 3.96 70 1 R.DFLLGAYQTEFPEGPTEQLMK.G

1 6.545735 3.96 52.6 2 R.DFLLGAYQTEFPEGPTEQLMK.G1 10.00481 3.86 73.3 2 K.GYGDSSSPPEIEEYAMELLCK.E1 7.186882 3.96 60.7 3 R.SIPVFNYQLYFQEPGVAEAELEK.N1 4.581896 3.96 54.1 1 R.SIPVFNYQLYFQEPGVAEAELEK.N

Tax_Id=10090 Gene_Symbol=Mccc1 Putative uncharacterized protein 1 4.473609 4.4 43.4 1 R.NSMHVDMADEAYSIGPAPSQQSYLAMEK.I1 5.990706 4.72 85 1 K.KSFNDDAMLIEK.F1 5.286065 4.14 100 1 K.SFNDDAMLIEK.F1 6.506928 4.72 61.7 1 K.IPLSQEEIPLQGHAFEAR.I

Tax_Id=10090 Gene_Symbol=Tmpo thymopoietin isoform delta Tax_Id=10090 Gene_Symbol=Tmpo thymopoietin isoform alpha Tax_Id=10090 Gene_Symbol=Tmpo thymopoietin isoform epsilon

1 5.473436 4.25 57.4 1 K.GPPDFSSDEEREPTPVLGSGASVGR.G1 8.554949 3.89 89.3 1 R.LEDKDDLDVTELSNEELLDQLVR.Y1 5.672938 3.89 50 1 R.LEDKDDLDVTELSNEELLDQLVR.Y

Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10A of 26S proteasome non-ATPase regulatory subunit 4 Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10D of 26S proteasome non-ATPase regulatory subunit 4

4 5.931435 4.12 48 1 K.EKVNVDIINFGEEEVNTEK.L1 9.102313 3.86 63.9 1 R.AAAASAAEAGIATPGTEDSDDALLK.M

Tax_Id=10090 Gene_Symbol=Psmd10 26S proteasome non-ATPase regulatory subunit 10 Tax_Id=10090 Gene_Symbol=Psmd10 proteasome 26S non-ATPase subunit 10 isoform 1

1 4.977909 4.28 44.3 1 K.ASTNIQDTEGNTPLHLACDEERVEEAK.FTax_Id=10090 Gene_Symbol=Mcfd2 Multiple coagulation factor deficiency protein 2 homolog

1 7.258707 4.12 66.7 2 R.DDDKNNDGYIDYAEFAK.STax_Id=10090 Gene_Symbol=Mrps14 28S ribosomal protein S14, mitochondrial Tax_Id=10090 Gene_Symbol=Mrps14 14 kDa protein

1 5.78579 3.96 87.5 2 K.DLQEMAGDEIAALPR.DTax_Id=10090 Gene_Symbol=Mvp major vault protein

1 9.050058 3.86 72.4 1 R.SVGAYLPAVFEEVLDLVDAVILTEK.T1 7.325101 3.86 42.6 1 R.SVGAYLPAVFEEVLDLVDAVILTEK.T1 11.54501 4.42 84.4 1 K.ALQPLEEGEGEEKVAHQAGDR.W1 9.51408 4.25 67.7 1 K.ELPSGVEELLNLGHDPLADR.G1 7.215295 3.96 75 1 R.MAVFGFEMSEDAGPDGALLPR.A1 9.082598 3.96 95.7 1 K.AQALAIETEAELER.V

Tax_Id=10090 Gene_Symbol=Aldh3a2 Fatty aldehyde dehydrogenase variant form Tax_Id=10090 Gene_Symbol=Aldh3a2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Aldh3a2 Aldehyde dehydrogenase family 3, subfamily A2 Tax_Id=10090 Gene_Symbol=Aldh3a2 Aldehyde dehydrogenase family 3, subfamily A2 Tax_Id=10090 Gene_Symbol=Aldh3a2 Putative uncharacterized protein

27 6.438215 4.25 32.5 2 K.SELNAYSHEVITILGEIDFMLGNLPELASAR.P1 5.747377 4.4 63 2 K.SPCYIDRDCDLDVACR.R1 5.163769 4.4 70.7 1 K.SPCYIDRDCDLDVACR.R1 6.628826 4.14 90 1 K.NVDEAINFINDR.E

Tax_Id=10090 Gene_Symbol=Ccdc47 Isoform 1 of Coiled-coil domain-containing protein 47 Tax_Id=10090 Gene_Symbol=Ccdc47 Coiled-coil domain containing 47 Tax_Id=10090 Gene_Symbol=Ccdc47 Isoform 2 of Coiled-coil domain-containing protein 47

1 7.507968 4.4 87.5 1 K.EMQDLSEFCSDKPK.S1 8.227061 3.86 67.7 1 K.YGLPDSLAILSEMGEVTEGMMDTK.M

1 4.381197 4.14 51.7 2 K.DMESLLPLMNMVIYSIDK.ATax_Id=10090 Gene_Symbol=Hnrpdl Heterogeneous nuclear ribonucleoprotein D-like Tax_Id=10090 Gene_Symbol=Hnrpdl heterogeneous nuclear ribonucleoprotein D-like

15 5.164732 3.95 29.8 1 K.VFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTK.TTax_Id=10090 Gene_Symbol=Pabpc1 Polyadenylate-binding protein 1 Tax_Id=10090 Gene_Symbol=Pabpc1 poly(A) binding protein, cytoplasmic 1

1 7.352915 4.46 88.9 1 R.SLGYAYVNFQQPADAER.A1 8.525616 4.72 91.7 1 K.GYGFVHFETQEAAER.A1 6.625256 4.25 100 2 K.NFGEDMDDERLK.E1 9.255654 4.42 80.8 4 K.NFGEDMDDERLKELFGK.F1 5.057188 4.42 59.1 1 K.NFGEDMDDERLKELFGK.F1 9.441607 4.25 92.6 3 K.ITGMLLEIDNSELLHMLESPESLR.S2 6.471026 4.25 44.8 2 K.ITGMLLEIDNSELLHMLESPESLR.S

Tax_Id=10090 Gene_Symbol=Eef1a1 Elongation factor 1-alpha 1 Tax_Id=10090 Gene_Symbol=Eef1a1 28 kDa protein

1 6.833761 4.89 100 1 R.TIEKFEKEAAEMGK.G1 5.732416 4.89 67.6 1 R.TIEKFEKEAAEMGK.G1 5.427823 4.46 77.8 4 K.MDSTEPPYSQK.R2 5.372785 4.89 40.3 1 K.DGSASGTTLLEALDCILPPTRPTDKPLR.L

Tax_Id=10090 Gene_Symbol=Haao 3-hydroxyanthranilate 3,4-dioxygenase 1 8.921898 3.96 90.9 1 R.YYVGDTEDVLFEK.W

30 4.050766 4.72 38.3 1 K.DLGTQLAPIIQEFFHSEQYR.TTax_Id=10090 Gene_Symbol=Gm4957 similar to ribosomal protein L12 Tax_Id=10090 Gene_Symbol=LOC100046569;Gm12038 similar to ribosomal protein L12

1 6.944868 4.4 75 1 H.HPHDIIDDINSGAVECPAS.-Tax_Id=10090 Gene_Symbol=Rps24 Isoform 2 of 40S ribosomal protein S24 Tax_Id=10090 Gene_Symbol=Rps24 Isoform 3 of 40S ribosomal protein S24 Tax_Id=10090 Gene_Symbol=Rps24;LOC677113 40S ribosomal protein S24

1 7.390958 4.46 100 1 K.TTGFGMIYDSLDYAK.KTax_Id=10090 Gene_Symbol=Cltc Clathrin heavy chain 1 Tax_Id=10090 Gene_Symbol=Cltc Clathrin, heavy polypeptide

1 6.933183 4.12 91.3 1 K.EDKLECSEELGDLVK.S1 6.677131 4.4 87 1 R.GQFSTDELVAEVEKR.N1 4.716145 3.8 36 1 R.LDNYDAPDIANIAISNELFEEAFAIFR.K1 5.343969 5.8 49.2 1 R.KFDVNTSAVQVLIEHIGNLDR.A1 5.630856 3.86 53.1 1 K.ADDPSSYMEVVQAANASGNWEELVK.Y1 6.784248 4.4 56.1 1 R.LAELEEFINGPNNAHIQQVGDR.C1 8.403449 3.96 83.3 1 R.GYFEELITMLEAALGLER.A1 5.196945 3.96 60 1 R.GYFEELITMLEAALGLER.A1 8.842337 3.96 74.1 1 K.SVNESLNNLFITEEDYQALR.T5 6.438036 4.19 37.1 1 K.DAMQYASESKDTELAEELLQWFLQEEKR.E1 7.194625 3.8 88.5 1 K.DTELAEELLQWFLQEEK.R1 8.005528 3.8 64.6 1 K.DTELAEELLQWFLQEEK.R1 7.08519 4.12 60 1 K.DTELAEELLQWFLQEEKR.E

Tax_Id=10090 Gene_Symbol=Hax1 HCLS1-associated protein X-1 1 6.349206 4.12 39.7 1 R.DFNSIFSEMGAWTLPSHSPELPGPESETPGER.L

Tax_Id=10090 Gene_Symbol=Hsp90b1 Endoplasmin 1 5.180466 4.03 69 1 R.TDDEVVQREEEAIQLDGLNASQIR.E

2 4.905041 4.03 43.3 1 R.TDDEVVQREEEAIQLDGLNASQIR.E1 5.866208 4.14 100 1 R.ELISNASDALDK.I1 7.497837 3.86 90.5 1 K.EEASDYLELDTIK.N

45 4.248128 4.12 36.7 1 K.KGYEVIYLTEPVDEYCIQALPEFDGK.R1 9.83665 4.42 50 1 K.KGYEVIYLTEPVDEYCIQALPEFDGKR.F1 7.49247 4.4 83.3 1 R.EATEKEFEPLLNWMK.D

Tax_Id=10090 Gene_Symbol=Lmna Isoform C of Lamin-A/C Tax_Id=10090 Gene_Symbol=Lmna Isoform A of Lamin-A/C

1 6.10975 4.25 100 1 R.LQEKEDLQELNDR.L2 5.069744 4.25 75 1 R.LQEKEDLQELNDR.L1 6.607827 3.96 95.8 1 R.MQQQLDEYQELLDIK.L1 7.817143 4.25 100 1 R.VAVEEVDEEGKFVR.L1 5.086625 4.22 47.6 1 R.SLTMVEDNEDDDEDGEELLHHHR.V

Tax_Id=10090 Gene_Symbol=Lmna Isoform C2 of Lamin-A/C 1 6.607827 3.96 95.8 1 R.MQQQLDEYQELLDIK.L1 7.817143 4.25 100 1 R.VAVEEVDEEGKFVR.L1 5.086625 4.22 47.6 1 R.SLTMVEDNEDDDEDGEELLHHHR.V

Tax_Id=10090 Gene_Symbol=Hsp90b1 43 kDa protein 45 4.248128 4.12 36.7 1 K.KGYEVIYLTEPVDEYCIQALPEFDGK.R

1 9.83665 4.42 50 1 K.KGYEVIYLTEPVDEYCIQALPEFDGKR.F1 7.49247 4.4 83.3 1 R.EATEKEFEPLLNWMK.D

Tax_Id=10090 Gene_Symbol=Flna 36 kDa protein 1 6.21134 4.84 55.3 1 K.THEAEIVEGENHTYCIR.F1 9.036875 3.96 73.3 1 K.DGSCGVAYVVQEPGDYEVSVK.F

Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Isoform 3 of Heterogeneous nuclear ribonucleoproteins A2/B1 Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Heterogeneous nuclear ribonucleoprotein A2/B1 Tax_Id=10090 Gene_Symbol=LOC100045191 similar to heterogeneous nuclear ribonucleoprotein A2/B1 Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Isoform 1 of Heterogeneous nuclear ribonucleoproteins A2/B1 Tax_Id=10090 Gene_Symbol=Hnrnpa2b1 Isoform 2 of Heterogeneous nuclear ribonucleoproteins A2/B1

1 7.181664 4.14 100 1 R.DYFEEYGK.I1 9.03064 4.12 88.5 5 R.DYFEEYGKIDTIEIITDR.Q1 4.969142 4.12 54 3 R.DYFEEYGKIDTIEIITDR.Q1 5.063314 4.14 100 1 K.IDTIEIITDR.Q1 7.609891 4.89 68.9 1 K.RGFGFVTFDDHDPVDK.I1 6.774116 4.4 100 1 R.GFGFVTFDDHDPVDK.I

Tax_Id=10090 Gene_Symbol=Gm6436 similar to ribosomal protein Tax_Id=10090 Gene_Symbol=EG630612 similar to ribosomal protein

1 5.802982 4.25 95 8 K.RAGELTEDEVER.V4 5.365396 4.25 69.7 1 K.RAGELTEDEVER.V1 5.668098 4.57 51.9 1 K.RAGELTEDEVERVITIMQNPR.Q

Tax_Id=10090 Gene_Symbol=Actg2 22 kDa protein 1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G

Tax_Id=10090 Gene_Symbol=Ndufs5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Tax_Id=10090 Gene_Symbol=Ndufs5 NADH dehydrogenase (Ubiquinone) Fe-S protein 5

1 8.02752 3.86 100 2 K.IEFDDFEECLLR.YTax_Id=10090 Gene_Symbol=Ddx21 Nucleolar RNA helicase 2 Tax_Id=10090 Gene_Symbol=Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

1 6.90452 4.25 66.7 1 K.LGSDGAEESMETLPKPSEK.K1 10.03427 4.25 96.4 2 K.SKTEEATEGMEEAVSSK.A1 5.836314 4.25 72.3 2 K.SKTEEATEGMEEAVSSK.A1 5.606886 4.03 69.2 1 K.EIITEEPS(79.9663)EEEADMPKPK.K1 4.976612 4.4 68 1 K.NGLSQPSEEEVDIPKPK.K1 8.442823 4.72 64.3 1 K.DSEDNPQTLLFSATCPHWVFNVAK.K

Tax_Id=10090 Gene_Symbol=Zc3hav1 Isoform 2 of Zinc finger CCCH-type antiviral protein 1 Tax_Id=10090 Gene_Symbol=Zc3hav1 Zc3hav1 protein

1 6.365308 3.86 55.2 2 R.MTLEELLGEISLPEAQLYELLK.A1 4.32614 3.86 42.9 1 R.MTLEELLGEISLPEAQLYELLK.A

17 6.629286 4.25 35.2 1 K.NHELSGLNQEELAVLLVQSDPFFMPEICK.S1 6.897825 3.86 92 2 R.ASQEFLEDGDPDGLFSR.N1 6.75282 3.96 88.5 2 R.WQLFILPTWMDFQDMEYIER.A

Tax_Id=10090 Gene_Symbol=Mybbp1a Putative uncharacterized protein 14 5.972123 3.86 35.6 1 R.PCYSLALAQLLQSFEDIPLCDILDQIQEK.Y

1 5.639654 3.96 79.3 1 K.ALVDILSEVPESMFQEILPK.V1 7.047584 3.96 55.6 1 R.VCFEDPEWEQLITQLLGK.A1 6.987885 9.08 77.3 1 K.SPAPSNPTLS(79.9663)PSTPAK.T

Tax_Id=10090 Gene_Symbol=Acox1 Peroxisomal acyl-coenzyme A oxidase 1 Tax_Id=10090 Gene_Symbol=Acox1 Acyl-Coenzyme A oxidase 1, palmitoyl, isoform CRA_a

1 9.32176 4.12 76 1 R.EIENLILNDPDFQHEDYNFLTR.S1 6.353046 3.96 78.3 1 R.EFGIADPEEIMWFK.K1 6.626176 4.4 48.3 1 R.INESIGQGDLSELPELHALTAGLK.A1 7.128127 4.14 86.4 2 R.YDGNVYENLFEWAK.K

Tax_Id=10090 Gene_Symbol=LOC100048437 similar to histone deacetylase isoform 1 Tax_Id=10090 Gene_Symbol=LOC100048437 similar to histone deacetylase isoform 2

1 11.7709 4.14 86.7 1 K.SEASGFCYVNDIVLAILELLK.Y1 6.431736 4.01 36.6 2 R.MLPHAPGVQMQAIPEDAIPEES(79.9663)GDEDEEDPDKR.I

Tax_Id=10090 Gene_Symbol=Nono Isoform 1 of Non-POU domain-containing octamer-binding protein 1 8.418042 3.96 72.4 3 R.NLPQYVSNELLEEAFSVFGQVER.A1 9.296268 3.96 55.4 1 R.NLPQYVSNELLEEAFSVFGQVER.A1 9.771823 3.69 86.7 2 R.PVTVEPMDQLDDEEGLPEK.L1 6.019292 4.4 94.4 2 R.EKLEMEMEAAR.H

Tax_Id=10090 Gene_Symbol=Psmb7 Proteasome subunit beta type-7 2 4.797265 4.57 64.1 4 K.FRPDMEEEEAKK.L1 6.169928 3.31 59.3 2 K.VTPLEIEVLEETVQTMDTS.-

Tax_Id=10090 Gene_Symbol=Fdx1 Adrenodoxin, mitochondrial Tax_Id=10090 Gene_Symbol=Fdx1 Putative uncharacterized protein

1 9.666034 3.69 73.3 1 K.LDAITDEENDMLDLAFGLTDR.STax_Id=10090 Gene_Symbol=Pop5 Ribonuclease P/MRP protein subunit POP5

2 4.187815 4.46 52 1 K.DFYQLVWSALPFITYLENK.GTax_Id=10090 Gene_Symbol=Gm16376 hypothetical protein Tax_Id=10090 Gene_Symbol=- 18 kDa protein Tax_Id=10090 Gene_Symbol=Gm9104 ribosomal protein L21-like Tax_Id=10090 Gene_Symbol=Gm16060 similar to ribosomal protein L21 Tax_Id=10090 Gene_Symbol=LOC100048241;Gm10155 hypothetical protein Tax_Id=10090 Gene_Symbol=Rpl21 60S ribosomal protein L21 Tax_Id=10090 Gene_Symbol=Gm7218 hypothetical protein

Tax_Id=10090 Gene_Symbol=LOC100047314;Gm11703 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm16415 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Gm5495 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Gm5445 similar to hCG1782414 isoform 1 Tax_Id=10090 Gene_Symbol=- 19 kDa protein Tax_Id=10090 Gene_Symbol=Gm10240;Rpl21;Gm15150;Gm10163;LOC100046290;Gm14648;LOC100044606 ribosomal protein L21 Tax_Id=10090 Gene_Symbol=Gm5201 hypothetical protein

1 5.689849 3.96 65.4 1 R.TNGKEPELLEPIPYEFMA.-Tax_Id=10090 Gene_Symbol=Mrpl55 Isoform 2 of 39S ribosomal protein L55, mitochondrial Tax_Id=10090 Gene_Symbol=Mrpl55 Isoform 1 of 39S ribosomal protein L55, mitochondrial

1 8.319513 4.03 84.6 2 K.REEEPEVVDSFDTER.YTax_Id=10090 Gene_Symbol=Rab7 Ras-related protein Rab-7a

1 8.027069 4.42 55.7 1 R.NALKQETEVELYNEFPEPIKLDK.NTax_Id=10090 Gene_Symbol=Lmna 13 kDa protein

1 6.10975 4.25 100 1 R.LQEKEDLQELNDR.L2 5.069744 4.25 75 1 R.LQEKEDLQELNDR.L

Tax_Id=10090 Gene_Symbol=Csnk2a1 Casein kinase II subunit alpha Tax_Id=10090 Gene_Symbol=Csnk2a1;Gm10031 casein kinase 2, alpha 1 polypeptide

1 6.248424 4.12 48.3 1 R.EYWDYESHVVEWGNQDDYQLVR.K3 6.536666 4.12 52 1 K.VLGTEDLYDYIDKYNIELDPR.F

Tax_Id=10090 Gene_Symbol=Mettl1 26 kDa protein Tax_Id=10090 Gene_Symbol=Mettl1 Protein

1 4.897523 4.25 48.4 3 R.YPVKPEEMDWSELYPEFFAPLIQNK.STax_Id=10090 Gene_Symbol=Eif5a Eukaryotic translation initiation factor 5A-1 Tax_Id=10090 Gene_Symbol=Eif5al3 similar to initiation factor 4D Tax_Id=10090 Gene_Symbol=Eif5al3 similar to initiation factor 4D Tax_Id=10090 Gene_Symbol=Eif5a 16 kDa protein

1 5.607254 4.4 85 1 R.EDLRLPEGDLGK.E1 5.598588 4.42 73.1 1 R.EDLRLPEGDLGKEIEQK.Y

Tax_Id=10090 Gene_Symbol=Mtdh Putative uncharacterized protein 1 8.890802 3.96 96 1 R.SWQDELAQQAEEGSAR.L

Tax_Id=10090 Gene_Symbol=Mtpn Myotrophin 1 6.072774 4.4 95.2 1 K.NGDLDEVKDYVAK.G

Tax_Id=10090 Gene_Symbol=Acta2 Putative uncharacterized protein 1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G

Tax_Id=10090 Gene_Symbol=H2afv Histone H2A Tax_Id=10090 Gene_Symbol=H2afv Histone H2A Tax_Id=10090 Gene_Symbol=H2afz Histone H2A Tax_Id=10090 Gene_Symbol=Gm8203;H2afz Histone H2A

1 5.80589 3.96 100 1 R.GDEELDSLIK.ATax_Id=10090 Gene_Symbol=Iqgap1 Ras GTPase-activating-like protein IQGAP1

1 7.507258 3.8 85.7 1 R.WMEACLGEDLPPTTELEEGLR.N1 8.789025 4.25 41.2 2 K.IGGILANELSVDEAALHAAVIAINEAIDR.R1 6.069089 3.96 70 2 R.DVYEELLTQAEIQGNVNK.V6 4.991059 4.03 36.7 1 K.AQETQDESAVLWLDEIQGGIWQSNKDTQEAQR.F1 7.221717 4.42 60 1 R.KFVHLLDQSDQDFQEELDLMK.M1 5.407948 4.42 65.1 1 K.DSLHEKFPDAGEDELLK.I1 5.206489 4.12 60.7 1 R.FQPGETLTEILETPATNEQEAEHQR.A

1 7.284911 3.86 60 1 K.NVIFEIGPTEEVGDFEVK.ATax_Id=10090 Gene_Symbol=Krt10 keratin complex 1, acidic, gene 10 Tax_Id=10090 Gene_Symbol=Krt10 Isoform 2 of Keratin, type I cytoskeletal 10

1 5.56328 6.56 100 2 K.VTMQNLNDR.L1 7.984779 3.96 100 1 R.ALEESNYELEGK.I1 7.490369 4.14 74.2 2 Q.NVSTGDVNVEMNAAPGVDLTQLLNNMR.N1 7.801102 4.14 43.7 1 Q.NVSTGDVNVEMNAAPGVDLTQLLNNMR.N1 8.320866 4.14 81.8 3 K.QSLEASLAETEGR.Y

Tax_Id=10090 Gene_Symbol=Adh1 Alcohol dehydrogenase 1 1 5.127352 4.7 26.6 1 R.SDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDK.V1 7.455008 4.7 37.3 1 R.SDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDK.V

Tax_Id=10090 Gene_Symbol=Snd1 Staphylococcal nuclease domain-containing protein 1 1 6.790843 3.96 84.4 1 K.DTNGENIAESLVAEGLATR.R1 6.796806 3.96 76.7 1 R.NLPGLVQEGEPFSEEATLFTK.E1 5.442255 3.86 94.1 1 R.EVEVEVESMDK.A2 5.8742 4.42 38.2 1 R.SASYKPVFVTEITDDLHFYVQDVETGTQLEK.L1 6.63541 4.25 69.2 1 R.YGDFRADDADEFGYSR.-1 5.135167 4.25 68.2 1 R.YGDFRADDADEFGYSR.-

Tax_Id=10090 Gene_Symbol=Ddx1 ATP-dependent RNA helicase DDX1 10 7.41545 4.14 53.6 2 R.DQLSVLDNGVDIVVGTPGR.L

1 10.15404 3.96 80 1 R.FLVLDEADGLLSQGYSDFINR.M1 7.277611 3.96 56.5 1 R.FLVLDEADGLLSQGYSDFINR.M1 6.433154 4.72 79.3 1 K.DNTRPGANSPEMWSEAIK.I1 5.675531 4.89 43.5 1 R.TKIDCDNLEQYFMQQGGGPDKK.G

Tax_Id=10090 Gene_Symbol=Gnl3 Isoform 1 of Guanine nucleotide-binding protein-like 3 1 3.914337 4.19 46 1 R.KLEVSPGDEQSNVETREESDEPK.R

31 4.58549 4.19 26.1 1 R.NAEISDVAPVEETRELSPEQS(79.9663)TAGKPSDGSSALDR.ATax_Id=10090 Gene_Symbol=G3bp2 Isoform A of Ras GTPase-activating protein-binding protein 2

1 8.50524 4.53 38.8 1 R.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.I6 7.538407 4.53 29.7 1 R.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.I1 8.630968 4.14 77.8 1 K.LPNFGFVVFDDSEPVQR.I

Tax_Id=10090 Gene_Symbol=Lsm14a Protein LSM14 homolog A 3 5.327813 12 42.3 1 R.RS(79.9663)PVPARPLPPTSQK.A1 7.056014 4.12 67.9 1 K.DFDFESANAQFNKEEIDR.E1 7.26134 4.53 49.2 1 K.DFDFESANAQFNKEEIDREFHNK.L1 7.138127 4.14 100 1 K.SFFDNISCDDNR.E

Tax_Id=10090 Gene_Symbol=Eif4a2 Isoform 1 of Eukaryotic initiation factor 4A-II Tax_Id=10090 Gene_Symbol=Eif4a2 eukaryotic translation initiation factor 4A2 isoform c Tax_Id=10090 Gene_Symbol=Eif4a2 Isoform 2 of Eukaryotic initiation factor 4A-II

13 7.668766 3.89 34.7 1 R.EHGGPEGMDPDGVIESNWNEIVDNFDDMNLK.E1 8.322711 3.96 100 1 K.MFVLDEADEMLSR.G

Tax_Id=10090 Gene_Symbol=Psmc6 26S protease regulatory subunit S10B 1 8.595842 4.4 78.6 1 R.DHQPCIIFMDEIDAIGGR.R1 6.156205 4.4 60.4 1 R.DHQPCIIFMDEIDAIGGR.R1 7.153346 4.72 100 1 K.HGEIDYEAIVK.L1 7.867796 4.4 90 1 R.ADHDFVVQEDFMK.A

Tax_Id=10090 Gene_Symbol=Mapre1 Microtubule-associated protein RP/EB family member 1 1 5.035925 4.4 94.1 1 K.LTVEDLEKER.D

1 6.829372 3.86 79.3 1 R.NIELICQENEGENDPVLQR.ITax_Id=10090 Gene_Symbol=Rps11 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Rps11 40S ribosomal protein S11 Tax_Id=10090 Gene_Symbol=Gm9808 hypothetical protein

1 7.684178 4.72 75.9 1 R.DVQIGDIVTVGECRPLSK.TTax_Id=10090 Gene_Symbol=Pabpc4 Putative uncharacterized protein

1 7.844271 4.72 95.8 2 K.GYAFVHFETQEAADK.A1 8.076706 4.89 59.2 1 K.GYAFVHFETQEAADKAIEK.M1 10.52515 4.25 96.4 1 K.NFGEEVDDGNLKELFSQFGK.T1 5.921812 4.25 54.7 1 K.NFGEEVDDGNLKELFSQFGK.T1 9.441607 4.25 92.6 3 K.ITGMLLEIDNSELLHMLESPESLR.S2 6.471026 4.25 44.8 2 K.ITGMLLEIDNSELLHMLESPESLR.S

Tax_Id=10090 Gene_Symbol=Krt10 Isoform 1 of Keratin, type I cytoskeletal 10 1 5.56328 6.56 100 2 R.VTMQNLNDR.L1 7.984779 3.96 100 1 R.ALEESNYELEGK.I1 7.490369 4.14 74.2 2 Q.NVSTGDVNVEMNAAPGVDLTQLLNNMR.N1 7.801102 4.14 43.7 1 Q.NVSTGDVNVEMNAAPGVDLTQLLNNMR.N1 8.320866 4.14 81.8 3 K.QSLEASLAETEGR.Y

Tax_Id=10090 Gene_Symbol=Nap1l1 Nucleosome assembly protein 1-like 1 Tax_Id=10090 Gene_Symbol=Nap1l1 nucleosome assembly protein 1-like 1 isoform 1

1 6.146759 4.4 87.5 1 K.FYEEVHDLER.K1 6.194678 3.87 39 1 R.FEIINAIYEPTEEECEWKPDEEDEVSEELKEK.A

Tax_Id=10090 Gene_Symbol=Ppm1a Protein phosphatase 1A 1 7.412701 4.25 85.2 1 K.GPTEQLVSPEPEVHDIER.S2 5.347387 4.42 46.6 2 R.SRLEVTDDLEKVCNEVVDTCLYK.G

Tax_Id=10090 Gene_Symbol=Lactb Putative uncharacterized protein 1 6.893195 3.96 87.5 1 K.EVWSEGLGYADVENR.V1 5.274165 4.28 46 1 K.LDLDLPVQHYVPEFPEKEYEGEK.V

Tax_Id=10090 Gene_Symbol=Lrrc59 Leucine-rich repeat-containing protein 59 Tax_Id=10090 Gene_Symbol=Lrrc59 Putative uncharacterized protein

1 3.701073 4.53 44.8 1 K.GGNLRDKLDGNELDLSLSDLNEVPVKELAALPK.A1 8.270069 4.12 93.8 1 R.DKLDGNELDLSLSDLNEVPVK.E

Tax_Id=10090 Gene_Symbol=Sfrs5 Splicing factor, arginine/serine-rich 5 Tax_Id=10090 Gene_Symbol=Sfrs5 31 kDa protein Tax_Id=10090 Gene_Symbol=Sfrs5 splicing factor, arginine/serine-rich 5 Tax_Id=10090 Gene_Symbol=Sfrs5 MCG7614, isoform CRA_c Tax_Id=10090 Gene_Symbol=Gm12966 similar to SRp40-1

1 7.35376 3.95 75 1 R.GFGFVEFEDPRDADDAVYELDGK.E1 5.781773 3.95 53.4 1 R.GFGFVEFEDPRDADDAVYELDGK.E1 5.652168 4.05 36.8 1 R.GFGFVEFEDPRDADDAVYELDGKELCSER.V

Tax_Id=10090 Gene_Symbol=Calml3 Calmodulin-like protein 3 Tax_Id=10090 Gene_Symbol=Gm7308 similar to calmodulin

1 4.308271 4.73 60.5 1 R.KMKDTDSEEEIREAFR.VTax_Id=10090 Gene_Symbol=Hspa9 Stress-70 protein, mitochondrial Tax_Id=10090 Gene_Symbol=Hspa9 heat shock protein 9

1 4.861875 6.56 94.7 1 K.DAGQISGLNVLR.V1 9.291413 3.96 56.7 1 K.STNGDTFLGGEDFDQALLR.H1 9.493024 4.4 81.2 1 R.EQQIVIQSSGGLSKDDIENMVK.N

1 10.16989 4.58 86.2 1 K.ERVEAVNMAEGIIHDTETK.M1 5.993227 4.58 73.6 1 K.ERVEAVNMAEGIIHDTETK.M1 5.505276 4.4 64 1 R.VEAVNMAEGIIHDTETK.M

Tax_Id=10090 Gene_Symbol=Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 1 8.371628 3.96 100 1 K.EAFIDYGEEFSGR.G1 6.362267 6.56 100 1 K.DKDFLSLIGK.V1 7.527198 4.89 87 2 K.IKEHEESLDVTNPR.D1 5.355848 4.89 67.4 19 K.IKEHEESLDVTNPR.D1 4.899073 7.41 59.5 1 R.NHMPYTNAMVHEVQR.Y

Tax_Id=10090 Gene_Symbol=Ndufa9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Tax_Id=10090 Gene_Symbol=Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 precursor

1 6.563823 4.14 95.2 1 R.NFDFEDVFVNIPR.A1 4.848465 4.25 52.7 1 R.IHISDVMPTDLPGLEDLGVQPTPLELK.S

Tax_Id=10090 Gene_Symbol=Pdhb Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 3 6.006567 3.86 40 1 R.DNNPVVMLENELMYGVAFELPAEAQSK.D1 6.303391 4.14 88.2 1 K.EGIECEVINLR.T

Tax_Id=10090 Gene_Symbol=Nipsnap1 Protein NipSnap homolog 1 Tax_Id=10090 Gene_Symbol=Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 Tax_Id=10090 Gene_Symbol=Nipsnap1 Putative uncharacterized protein

1 4.633239 4.58 36.4 1 K.LHLDEDYPCSLVGNWNTWYGEQDQAVHLWR.FTax_Id=10090 Gene_Symbol=Hba-a1;Hba-a2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Hba-a1;Hba-a2 hemoglobin alpha, adult chain 2 Tax_Id=10090 Gene_Symbol=Hba-a1;Hba-a2 Hemoglobin subunit alpha

1 6.717183 4.72 75 2 K.IGGHGAEYGAEALER.MTax_Id=10090 Gene_Symbol=Gm2000;Rpl35 60S ribosomal protein L35 Tax_Id=10090 Gene_Symbol=Gm10269 similar to ribosomal protein L35

1 5.270735 4.72 61.5 1 K.QLDDLKVELSQLR.VTax_Id=10090 Gene_Symbol=Acsm3 Isoform 2 of Acyl-coenzyme A synthetase ACSM3, mitochondrial Tax_Id=10090 Gene_Symbol=Acsm3 Isoform 1 of Acyl-coenzyme A synthetase ACSM3, mitochondrial

1 4.949604 4.46 83.3 1 K.IEIPEYFNFAK.D1 5.421986 4.25 43.9 1 K.IEIPEYFNFAKDVLDQWTNMEK.A1 7.514735 4.14 94.4 1 K.DVLDQWTNMEK.A1 5.971148 4.72 71 1 K.HCVSAGEPINPEVMEQWR.K1 8.746247 4.14 100 2 R.GYMDEDGYFWFVAR.S1 7.951169 4.46 94.4 1 R.SDDIILSSGYR.I

Tax_Id=10090 Gene_Symbol=Nono Isoform 2 of Non-POU domain-containing octamer-binding protein 1 8.418042 3.96 72.4 3 R.NLPQYVSNELLEEAFSVFGQVER.A1 9.296268 3.96 55.4 1 R.NLPQYVSNELLEEAFSVFGQVER.A

Tax_Id=10090 Gene_Symbol=Ndufa8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 9.000395 4.25 66.7 2 M.PGIVELPTLEELKVEEVK.V

Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO3 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 71 kDa protein Tax_Id=10090 Gene_Symbol=Fmr1 67 kDa protein Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO8 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO1 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO7 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Fragile X mental retardation syndrome 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO12 of Fragile X mental retardation protein 1 homolog

Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO11 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO10 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO9 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO6 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO5 of Fragile X mental retardation protein 1 homolog Tax_Id=10090 Gene_Symbol=Fmr1 Isoform ISO4 of Fragile X mental retardation protein 1 homolog

1 8.672832 4.25 69 2 K.DVHEDSITVAFENNWQPER.Q1 7.738663 3.86 95.5 1 K.DINESDEVEVYSR.A4 7.546865 4.28 37.5 1 R.KVPGVTAIDLDEDTCTFHIYGEDQDAVK.K1 4.676683 4.53 39.4 1 R.KVPGVTAIDLDEDTCTFHIYGEDQDAVKK.A

Tax_Id=10090 Gene_Symbol=Ugt2b38 UDP glucuronosyltransferase 2 family, polypeptide B38 1 6.190502 3.96 56 1 R.DTCLSYSPLLQNMIDEFSDYFLSLCK.D1 7.616625 3.96 49.3 1 R.DTCLSYSPLLQNMIDEFSDYFLSLCK.D1 5.527166 3.96 46.8 1 K.FDVLLSDPVASCGELIAELLQIPFLYSIR.F

Tax_Id=10090 Gene_Symbol=Pdia5 Protein disulfide-isomerase A5 1 9.350843 3.96 69 1 R.FLFPYENYGSTAEDIVEWLK.N1 5.99572 4.03 35.8 1 K.NPLPPQPQVPETPWADEGGSVYHLTDEDFDQFVK.E

Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 2 of Heterogeneous nuclear ribonucleoprotein D0 Tax_Id=10090 Gene_Symbol=Hnrnpd Isoform 4 of Heterogeneous nuclear ribonucleoprotein D0

1 5.4364 4.14 79.2 1 K.IFVGGLSPDTPEEK.I1 6.136543 4.25 70 1 K.IREYFGGFGEVESIELPMDNK.T1 5.086267 4.25 49.2 1 K.IREYFGGFGEVESIELPMDNK.T1 8.062141 3.86 73.3 4 R.EYFGGFGEVESIELPMDNK.T

Tax_Id=10090 Gene_Symbol=Golph3 Isoform 1 of Golgi phosphoprotein 3 3 5.100033 4.25 36.7 1 R.LLALIYLAHASDVLENAFAPLLDEQYDLATK.R

Tax_Id=10090 Gene_Symbol=Caprin1 cytoplasmic activation/proliferation-associated protein 1 isoform c Tax_Id=10090 Gene_Symbol=Caprin1 cytoplasmic activation/proliferation-associated protein 1 isoform b Tax_Id=10090 Gene_Symbol=Caprin1 Caprin-1

1 10.63875 4.25 79.3 2 K.TVLELQYVLDKLGDDDVR.T1 6.620285 4.25 60.4 1 K.TVLELQYVLDKLGDDDVR.T1 5.818895 4.42 50 1 K.TVLELQYVLDKLGDDDVRTDLK.Q1 9.103195 3.86 79.3 1 K.QGLSGVPILSEEELSLLDEFYK.L4 5.829955 3.86 40.6 1 K.QGLSGVPILSEEELSLLDEFYK.L1 8.783781 4.84 84 1 R.LNEQYEHASIHLWDLLEGK.E1 8.155943 4.84 56.9 1 R.LNEQYEHASIHLWDLLEGK.E1 4.936807 6.56 92.3 2 R.DGYQQNFK.R

Tax_Id=10090 Gene_Symbol=Coro1c Coronin-1C 23 5.487812 4.72 45.3 1 R.YFEITDESPYVHYLNTFSSK.E

1 7.997066 3.89 48.7 1 R.KSDLFQDDLYPDTAGPEAALEAEEWFEGK.NTax_Id=10090 Gene_Symbol=Eef1d Isoform 1 of Elongation factor 1-delta Tax_Id=10090 Gene_Symbol=Eef1d Isoform 3 of Elongation factor 1-delta Tax_Id=10090 Gene_Symbol=Eef1d 27 kDa protein Tax_Id=10090 Gene_Symbol=Eef1d 22 kDa protein Tax_Id=10090 Gene_Symbol=Eef1d 23 kDa protein Tax_Id=10090 Gene_Symbol=Eef1d Isoform 2 of Elongation factor 1-delta

1 5.886336 3.87 42.5 1 K.GATPAEDDEDKDIDLFGS(79.9663)DEEEEDKEAAR.LTax_Id=10090 Gene_Symbol=Ak2 Isoform 2 of Adenylate kinase 2, mitochondrial Tax_Id=10090 Gene_Symbol=Ak2 Isoform 1 of Adenylate kinase 2, mitochondrial

1 7.077914 3.96 100 1 K.LVSDEMVVELIEK.N1 5.449914 3.96 76.5 1 R.QAEMLDDLMEK.R

Tax_Id=10090 Gene_Symbol=Gm14072 hypothetical protein isoform 3 1 6.04101 5.8 66.7 1 K.HKELAPYDENWFYTR.A1 7.645445 4.14 95.2 2 K.ELAPYDENWFYTR.A

Tax_Id=10090 Gene_Symbol=Sart1 U4/U6.U5 tri-snRNP-associated protein 1 1 8.513891 3.8 85.7 1 K.TLGEDDPWLDDTAAWIER.S1 8.600522 4.42 62.1 2 K.DKGVLQDGEDVLVNVNMVDKER.A1 7.846833 4.73 48.5 2 K.KKPDYLPYAEDESVDDLAQQKPR.S1 5.85188 3.86 63.3 1 R.ADDLLPLGDQTQDGDFGSR.L

Tax_Id=10090 Gene_Symbol=Acox1 Putative uncharacterized protein 1 5.082107 4.95 38.5 1 R.GHPEPLDLHLGMFLPTLLHQATEEQQER.F1 6.626176 4.4 48.3 1 R.INESIGQGDLSELPELHALTAGLK.A1 7.128127 4.14 86.4 2 R.YDGNVYENLFEWAK.K

Tax_Id=10090 Gene_Symbol=Dars Aspartyl-tRNA synthetase, cytoplasmic Tax_Id=10090 Gene_Symbol=Dars aspartyl-tRNA synthetase isoform 1

1 6.173244 4.25 85.7 1 R.EIVDAAEDYAKER.Y1 6.071553 4.03 69 1 R.LPLQLDDAIRPEVEGEEDGR.A2 7.405902 3.64 57.1 2 R.EAGVEMDDEEDLSTPNEK.L

no description1 5.56328 6.56 100 2 K.VTMQNLNDR.L1 6.356577 3.96 95 1 R.ALEEANADLEVK.I1 7.707012 4.25 85.2 1 R.ADLEMQIESLKEELAYLK.K1 5.681929 4.25 60.9 1 R.ADLEMQIESLKEELAYLK.K1 6.362315 4.14 92.9 1 K.DAEEWFFTK.T

Tax_Id=10090 Gene_Symbol=Ddt D-dopachrome decarboxylase 1 5.966881 3.96 90 1 K.FLTEELSLDQDR.I

Tax_Id=10090 Gene_Symbol=Ap2m1 AP-2 complex subunit mu Tax_Id=10090 Gene_Symbol=Ap2m1 Adaptor protein complex AP-2, mu1, isoform CRA_a

1 5.872308 3.86 42.5 1 K.NNFVLIYELLDEILDFGYPQNSETGALK.T1 5.451665 3.96 72 1 K.ESQISAEIELLPTNDK.K

Tax_Id=10090 Gene_Symbol=Acta1 Actin, alpha skeletal muscle Tax_Id=10090 Gene_Symbol=Actg2 30 kDa protein Tax_Id=10090 Gene_Symbol=Actc1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Actc1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Actc1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Actg2 Actin, gamma-enteric smooth muscle Tax_Id=10090 Gene_Symbol=Actg2 Smooth muscle gamma-actin Tax_Id=10090 Gene_Symbol=Acta2 Actin, aortic smooth muscle Tax_Id=10090 Gene_Symbol=Actc1 Actin, alpha cardiac muscle 1

1 5.45591 4.46 100 1 K.AGFAGDDAPR.A1 7.35542 4.72 89.5 4 K.DSYVGDEAQSKR.G1 6.187113 4.14 84 2 K.SYELPDGQVITIGNER.F

Tax_Id=10090 Gene_Symbol=Ap1s1 AP-1 complex subunit sigma-1A 1 8.42316 3.8 88.5 1 K.AIEQADLLQEEDESPR.S

Tax_Id=10090 Gene_Symbol=Pfn1 Profilin-1 Tax_Id=10090 Gene_Symbol=Pfn1 Profilin

1 7.592358 3.96 95.5 1 R.DSLLQDGEFTMDLR.T

Tax_Id=10090 Gene_Symbol=Gm9093 similar to Acidic ribosomal phosphoprotein P0 1 7.536709 4.4 47.4 1 S.SFGLIIQQVFDNGSIYNPEVLDITEQALHSR.F

Tax_Id=10090 Gene_Symbol=Rpl9;Gm10321 60S ribosomal protein L9 Tax_Id=10090 Gene_Symbol=Rpl9 9 kDa protein Tax_Id=10090 Gene_Symbol=Rpl9 19 kDa protein Tax_Id=10090 Gene_Symbol=Gm10117 similar to 60S ribosomal protein L9 isoform 2 Tax_Id=10090 Gene_Symbol=Gm10117 similar to 60S ribosomal protein L9 isoform 1 Tax_Id=10090 Gene_Symbol=Gm5451 similar to 60S ribosomal protein L9

1 6.052137 4.14 77.8 1 K.TILSNQTVDIPENVEITLK.GTax_Id=10090 Gene_Symbol=Fth1 Ferritin heavy chain

1 6.929183 4.25 51.7 2 R.DDWESGLNAMECALHLEK.STax_Id=10090 Gene_Symbol=Sep15 15 kDa selenoprotein

1 6.9551 4.25 64.3 1 K.WNTDSVEEFLSEKLER.ITax_Id=10090 Gene_Symbol=Myl6 Isoform Non-muscle of Myosin light polypeptide 6 Tax_Id=10090 Gene_Symbol=Gm8894 similar to non-muscle myosin alkali light chain Tax_Id=10090 Gene_Symbol=Gm8894 similar to non-muscle myosin alkali light chain Tax_Id=10090 Gene_Symbol=Gm5915 similar to 17,000 dalton myosin light chain Tax_Id=10090 Gene_Symbol=Gm5526 similar to MYL6 protein

1 7.971284 4.4 83.3 2 K.NKDQGTYEDYVEGLR.V1 5.92978 4.4 80.5 1 K.NKDQGTYEDYVEGLR.V1 7.658019 3.96 86.4 1 K.DQGTYEDYVEGLR.V

Tax_Id=10090 Gene_Symbol=Otud4 Otud4 protein 1 8.69344 4.14 70.8 2 K.DSSAMCQSLLYELLYEK.V3 5.150013 4.14 77.8 1 R.ESYYFGLSPEER.R1 5.187617 5.66 55.6 1 R.GHTHVDKKPEPSTLEISDDK.C3 5.58985 4.12 41.2 1 R.QNIVLPPDDKGELDLPLENLDLSK.E1 8.253922 3.86 84 3 K.ECDSVSAVDEFPDAR.V8 5.47487 4.42 46.2 1 R.LQRPKEES(79.9663)S(79.9663)EDENEVSNILR.S

Tax_Id=10090 Gene_Symbol=Hsph1 Isoform HSP105-alpha of Heat shock protein 105 kDa Tax_Id=10090 Gene_Symbol=Hsph1 Putative uncharacterized protein

1 7.963583 4.14 95 2 R.AGGIETIANEFSDR.C1 5.823019 4.4 57.4 1 R.RGPFELEAFYSDPQGVPYPEAK.I1 7.351387 3.83 45.9 1 K.VPTEEEDGSSLEADMECPNQRPTESSDVDK.N1 9.918936 3.69 85.7 1 R.LLTETEDWLYEEGEDQAK.Q

Tax_Id=10090 Gene_Symbol=Eif6 Eukaryotic translation initiation factor 6 Tax_Id=10090 Gene_Symbol=Eif6 Eukaryotic translation initiation factor 6

1 8.26529 3.96 66.7 2 K.TSIEDQDELSSLLQVPLVAGTVNR.G1 4.975964 3.96 52.2 1 K.TSIEDQDELSSLLQVPLVAGTVNR.G

Tax_Id=10090 Gene_Symbol=Mobkl3 Mps one binder kinase activator-like 3 1 5.957855 3.23 64.5 1 K.DNLIVPILEEEVQNSVSGESEA.-

Tax_Id=10090 Gene_Symbol=Cps1 Carbamoyl-phosphate synthetase 1 1 9.127857 3.96 95.7 1 K.IEFEGQSVDFVDPNK.Q1 8.087425 4.25 64.3 1 K.IEFEGQSVDFVDPNKQNLIAEVSTK.D

30 6.211952 4.25 37.9 2 K.IEFEGQSVDFVDPNKQNLIAEVSTK.D1 10.09746 4.14 91.7 1 K.VLGTSVESIMATEDR.Q1 6.18574 4.42 40 1 K.VLGTSVESIMATEDRQLFSDKLNEINEK.I1 8.127963 4.14 95.8 2 K.IAPSFAVESMEDALK.A1 8.66831 4.14 85.7 1 K.GLNSDSVTEETLR.K

1 7.204567 4.19 38.7 1 K.KTVVVNCNPETVSTDFDECDKLYFEELSLER.ITax_Id=10090 Gene_Symbol=Trim28 Isoform 1 of Transcription intermediary factor 1-beta Tax_Id=10090 Gene_Symbol=Trim28 Isoform 2 of Transcription intermediary factor 1-beta

34 5.423859 5.8 31.5 1 K.RPAASSAAAASAAAS(79.9663)SPAGGGGEAQELLEHCGVCR.E1 6.485851 4.72 94.7 1 K.DHQYQFLEDAVR.N8 7.899284 4.25 34.1 1 K.QGSGSSQPMEVQEGYGFGSDDPYSSAEPHVSGMK.R

Tax_Id=10090 Gene_Symbol=D10Wsu52e UPF0027 protein C22orf28 homolog 1 5.401273 4.14 94.4 1 R.NYNDELQFLDK.I1 10.62168 4.42 77.8 1 R.EGYAWAEDKEHCEEYGR.M1 5.658585 4.14 100 1 R.NLDFQDVLDK.L1 6.005256 4.14 94.4 1 K.LVMEEAPESYK.N

Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 3 of Heterogeneous nuclear ribonucleoprotein U-like protein 1 16 4.255572 4.23 30.3 1 R.RGRS(79.9663)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK.V

Tax_Id=10090 Gene_Symbol=Dusp3 Dual specificity protein phosphatase 3 Tax_Id=10090 Gene_Symbol=Dusp3 Dual specificity phosphatase 3

1 7.534622 4.14 58.6 1 R.EIGPNDGFLAQLCQLNDR.LTax_Id=10090 Gene_Symbol=Anxa2 Annexin A2

1 7.932013 4.25 88.5 1 K.TDLEKDIISDTSGDFR.K1 5.897157 4.25 63.3 1 K.TDLEKDIISDTSGDFR.K1 5.161139 4.57 87 1 K.TDLEKDIISDTSGDFRK.L

Tax_Id=10090 Gene_Symbol=Rrbp1 Isoform 3 of Ribosome-binding protein 1 Tax_Id=10090 Gene_Symbol=Rrbp1 ribosome binding protein 1 isoform a

1 7.573163 4.72 95.2 1 R.LKELESQVSCLEK.E2 4.216785 4.53 42.4 1 R.LKELESQVSCLEKETSELKEAMEQQK.G

33 4.257362 4.72 36.8 2 K.ETLLALLPGLSISAHQNYAEWLQEFK.E1 8.131578 4.25 82.1 1 K.LREAEETQNSLQAECDQYR.T1 5.227438 4.25 59.3 1 K.LREAEETQNSLQAECDQYR.T1 10.42537 3.86 85.7 2 R.EAEETQNSLQAECDQYR.T1 4.682747 4.72 92.3 1 K.HLEDIVEK.L1 6.704942 4.72 95 5 K.LKGELESSDQVR.E1 7.29374 4.84 95 2 R.EHTSHLEAELEK.H1 7.876478 4.42 44.6 1 R.QLLLESQSQLDEAKSEAQKQSDELALVR.Q1 8.837189 4.25 73.5 2 R.SHVEDGDVAGSPAVPPAEQDPMK.L

Tax_Id=10090 Gene_Symbol=Fxr1 Isoform E of Fragile X mental retardation syndrome-related protein 1 Tax_Id=10090 Gene_Symbol=Fxr1 Isoform F of Fragile X mental retardation syndrome-related protein 1 Tax_Id=10090 Gene_Symbol=Fxr1 Isoform D of Fragile X mental retardation syndrome-related protein 1 Tax_Id=10090 Gene_Symbol=Fxr1 Isoform C of Fragile X mental retardation syndrome-related protein 1 Tax_Id=10090 Gene_Symbol=Fxr1 Isoform B of Fragile X mental retardation syndrome-related protein 1 Tax_Id=10090 Gene_Symbol=Fxr1 Isoform A of Fragile X mental retardation syndrome-related protein 1

1 11.67368 4.25 100 1 K.DVHEDSLTVVFENNWQPER.Q2 6.526842 4.25 48.2 2 K.DVHEDSLTVVFENNWQPER.Q1 6.275707 4.25 95.8 1 K.KEISEGDEVEVYSR.A1 6.905198 3.86 95.2 1 K.EISEGDEVEVYSR.A1 5.857449 4.14 100 2 R.GFLEFVEDFIQVPR.N2 7.020724 4.14 62.2 1 R.GFLEFVEDFIQVPR.N1 6.286781 4.12 80 1 R.KDELSDWSLAGEDDR.E1 6.122984 4.28 55.2 1 R.KDELSDWSLAGEDDRETR.H1 6.853172 4.28 49.1 1 R.KDELSDWSLAGEDDRETR.H

Tax_Id=10090 Gene_Symbol=Cyp2c37 cytochrome P450, family 2, subfamily c, polypeptide 37 1 4.978395 4.89 78 1 K.IKEHEESLDVTIPR.D1 8.734098 3.96 86.2 2 R.DFIDYFLINGGQEDGNQPLQNR.L1 7.538657 3.96 50.7 1 R.DFIDYFLINGGQEDGNQPLQNR.L1 5.42104 4.72 94.4 1 K.VQEEIEHVIGK.H

Tax_Id=10090 Gene_Symbol=Serbp1 Isoform 1 of Plasminogen activator inhibitor 1 RNA-binding protein Tax_Id=10090 Gene_Symbol=Serbp1 SERPINE1 mRNA binding protein 1 isoform 2 Tax_Id=10090 Gene_Symbol=Serbp1 Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein Tax_Id=10090 Gene_Symbol=Serbp1 Isoform 2 of Plasminogen activator inhibitor 1 RNA-binding protein

1 5.738137 5.56 52.5 1 K.SKSEEAHAEDSVMDHHFR.K1 6.713977 3.86 73.3 1 R.TDKSSASAPDVDDPEAFPALA.-

Tax_Id=10090 Gene_Symbol=LOC639023 similar to cytochrome P450 1 7.036241 4.72 86.4 1 K.EALVDHGDVFAGR.G1 5.331432 4.57 69 1 K.DRDFLNLLEKLDEISK.I

Tax_Id=10090 Gene_Symbol=Mtch2 Mitochondrial carrier homolog 2 Tax_Id=10090 Gene_Symbol=Mtch2 Mtch2 protein (Fragment)

1 8.716488 4.4 79.3 1 K.VLQYYQESEKPEELGSVTVQK.E1 6.712747 4.4 56.4 1 K.VLQYYQESEKPEELGSVTVQK.E

53 5.236451 4.42 31.2 1 K.VLQYYQESEKPEELGSVTVQKEYSSSFDR.VTax_Id=10090 Gene_Symbol=Pabpc4 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Pabpc1 Protein

1 9.441607 4.25 92.6 3 K.ITGMLLEIDNSELLHMLESPESLR.S2 6.471026 4.25 44.8 2 K.ITGMLLEIDNSELLHMLESPESLR.S

Tax_Id=10090 Gene_Symbol=Psmb1 Proteasome subunit beta type-1 1 6.067314 5.63 95.2 1 K.NMQNVEHVPLTLDR.A1 5.475769 5.63 73 1 K.NMQNVEHVPLTLDR.A2 5.257895 4.46 93.3 1 K.DVFISAAER.D

Tax_Id=10090 Gene_Symbol=Nop16 Nucleolar protein 16 Tax_Id=10090 Gene_Symbol=Nop16 22 kDa protein

1 10.01783 4.4 92.9 1 R.KPYVVNDLEAEASLPEK.KTax_Id=10090 Gene_Symbol=0610009D07Rik Pre-mRNA branch site protein p14

1 6.152386 4.14 72.2 1 K.ITAEEMYDIFGK.YTax_Id=10090 Gene_Symbol=Opa1 Protein

7 4.885181 4.12 38.6 1 K.SLIDMYSEVLDVLSDYDASYNTQDHLPR.VTax_Id=10090 Gene_Symbol=Gadd45gip1 Growth arrest and DNA damage-inducible proteins-interacting protein 1

1 8.799954 3.8 80.8 1 R.ELEAEEQEWYPSLATMQESLR.LTax_Id=10090 Gene_Symbol=Camk2a Isoform Alpha KAP of Calcium/calmodulin-dependent protein kinase type II subunit alpha Tax_Id=10090 Gene_Symbol=Camk2a 26 kDa protein Tax_Id=10090 Gene_Symbol=Camk2a 21 kDa protein Tax_Id=10090 Gene_Symbol=Camk2a Isoform Alpha CaMKII of Calcium/calmodulin-dependent protein kinase type II subunit alpha Tax_Id=10090 Gene_Symbol=Camk2a MKIAA0968 protein

1 7.276726 3.96 88.9 1 K.VTEQLIEAISNGDFESYTK.MTax_Id=10090 Gene_Symbol=Rpl36 60S ribosomal protein L36 Tax_Id=10090 Gene_Symbol=- 10 kDa protein Tax_Id=10090 Gene_Symbol=LOC100048508;Rpl36 ribosomal protein L36 Tax_Id=10090 Gene_Symbol=LOC100045157;Gm10168 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm5745 hypothetical protein

2 5.820196 4.46 76.5 1 R.EVCGFAPYER.R

Tax_Id=10090 Gene_Symbol=Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 1 7.451894 3.96 81.5 1 K.MSINAEDVVVGDLVEVK.G1 6.751909 4.03 57.1 1 K.EQPLDEELKDAFQNAYLELGGLGER.V1 9.447263 3.96 96.3 2 K.GVGIISEGNETVEDIAAR.L1 7.731883 3.86 90 2 K.DMTSEELDDILR.Y9 7.105843 4.03 36.9 1 R.ETWDDRWVNDVEDSYGQQWTYEQR.K

Tax_Id=10090 Gene_Symbol=Ncbp1 Nuclear cap-binding protein subunit 1 1 9.051475 4.25 82.1 1 K.TSDANETEDHLESLICK.V1 8.400842 4.25 68.8 1 R.MFDYTDDPEGPVMPGSHSVER.F1 6.906148 4.25 50.9 2 R.WSWEDWSDCLTQDLESPKPK.F1 8.157312 3.8 73.1 1 K.DVPNPNQVDDDDEGFR.F

Tax_Id=10090 Gene_Symbol=Cct3 T-complex protein 1 subunit gamma 1 6.331768 4.28 38.2 1 R.ILQMEEEYIHQLCEDIIQLKPDVVITEK.G1 5.205732 4.42 55.9 1 R.IVSRPEELREDDVGTGAGLLEIK.K

Tax_Id=10090 Gene_Symbol=Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 Tax_Id=10090 Gene_Symbol=Cyp2c67 Putative uncharacterized protein

1 6.362267 6.56 100 1 K.DKDFLSLIGK.V1 7.527198 4.89 87 2 K.IKEHEESLDVTNPR.D1 5.355848 4.89 67.4 19 K.IKEHEESLDVTNPR.D1 5.566691 4.46 100 1 R.DFIDYFLIQR.R1 4.899073 7.41 59.5 1 R.NHMPYTNAMVHEVQR.Y

Tax_Id=10090 Gene_Symbol=Ptbp1 MCG13402, isoform CRA_d 1 8.096987 4.89 63.3 1 R.EGQEDQGLTKDYGSSPLHR.F1 4.61389 4.89 57.1 1 R.EGQEDQGLTKDYGSSPLHR.F1 5.382919 7.33 100 1 K.DYGSSPLHR.F1 4.703752 4.72 44.6 1 K.NFQNIFPPSATLHLSNIPPSVSEDDLK.S

Tax_Id=10090 Gene_Symbol=Hspa4 Heat shock 70 kDa protein 4 1 6.887048 4.14 77.3 1 R.AGGIETIANEYSDR.C1 7.104699 4.14 100 1 K.NAVEEYVYEMR.D1 6.356958 4.58 68.2 1 K.NKEDQYEHLDAADVTK.V1 5.302198 4.71 57.1 1 K.NKEDQYEHLDAADVTKVEK.S1 5.159682 4.71 58.4 1 K.NKEDQYEHLDAADVTKVEK.S1 8.088004 4.28 45.1 3 K.HAEQNGPVDGQGDNPGSQAAEHGADTAVPSDGDK.K

Tax_Id=10090 Gene_Symbol=Otc Ornithine carbamoyltransferase, mitochondrial Tax_Id=10090 Gene_Symbol=Otc Otc protein

1 8.615845 3.96 64.3 1 R.GGNVLITDTWISMGQEDEK.K1 8.0696 4.25 95.7 1 R.KPEEVDDEVFYSPR.S

Tax_Id=10090 Gene_Symbol=Rab1 Ras-related protein Rab-1A Tax_Id=10090 Gene_Symbol=Rab1 RAB1, member RAS oncogene family Tax_Id=10090 Gene_Symbol=Rab1b Ras-related protein Rab-1B

1 6.173169 3.96 60.7 1 R.FADDTYTESYISTIGVDFK.ITax_Id=10090 Gene_Symbol=Cyp2c50 Isoform 1 of Cytochrome P450 2C50

1 4.978395 4.89 78 1 K.IKEHEESLDVTIPR.D1 6.840579 3.96 76.7 3 R.DFIDYFLINGGQEDGNYPLK.N1 5.42104 4.72 94.4 1 K.VQEEIEHVIGK.H

Tax_Id=10090 Gene_Symbol=Bysl Bystin 1 7.978222 3.64 88.5 2 R.LGPGLPQDGS(79.9663)DEEDEEWPTLEK.A1 7.448002 4.12 73.3 1 K.MAGVDHQAEVIVDPEDER.A

Tax_Id=10090 Gene_Symbol=Prkar2a cAMP-dependent protein kinase type II-alpha regulatory subunit Tax_Id=10090 Gene_Symbol=Prkar2a Protein kinase, cAMP dependent regulatory, type II alpha, isoform CRA_b

1 10.08119 3.96 70.4 2 K.NLDQEQLSQVLDAMFEK.I1 8.640799 4.03 100 1 K.TDEHVIDQGDDGDNFYVIER.G

Tax_Id=10090 Gene_Symbol=Capzb Isoform 2 of F-actin-capping protein subunit beta Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_a Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta Tax_Id=10090 Gene_Symbol=Capzb Capping protein (Actin filament) muscle Z-line, beta Tax_Id=10090 Gene_Symbol=Capzb Isoform 1 of F-actin-capping protein subunit beta

1 4.734866 3.86 70.4 1 K.NLSDLIDLVPSLCEDLLSSVDQPLK.ITax_Id=10090 Gene_Symbol=Rab18 Ras-related protein Rab-18

2 6.097272 3.86 46.9 1 R.FTDDTFDPELAATIGVDFK.VTax_Id=10090 Gene_Symbol=Rer1 Protein RER1

1 7.746765 3.86 73.3 1 K.VDPSLMEDSDDGPSLPTK.QTax_Id=10090 Gene_Symbol=Hadhb 19 kDa protein

1 6.746629 4.14 68 2 K.DVVDYIIFGTVIQEVK.TTax_Id=10090 Gene_Symbol=Glrx5 Glutaredoxin-related protein 5, mitochondrial

1 7.375497 3.96 91.3 1 R.DYAAYNVLDDPELR.QTax_Id=10090 Gene_Symbol=Gcdh Glutaryl-CoA dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Gcdh glutaryl-Coenzyme A dehydrogenase precursor

1 7.005584 4.42 59.3 8 K.SSRPVFDWKDPLILEEQLTADEK.L1 7.554172 3.86 91.3 1 K.DPLILEEQLTADEK.L1 7.075278 4.14 60.7 1 R.DIVYEMGELGVLGPTIK.G

Tax_Id=10090 Gene_Symbol=Actr3 Actin-related protein 3 1 9.025684 4.12 88.9 1 K.GVDDLDFFIGDEAIEKPTYATK.W1 6.262422 4.4 80 1 R.DREVGIPPEQSLETAK.A

Tax_Id=10090 Gene_Symbol=Mpst 3-mercaptopyruvate sulfurtransferase 18 5.260274 4.25 35.7 1 R.DGIEPGHIPGSVNIPFTEFLTNEGLEK.S

Tax_Id=10090 Gene_Symbol=Psmb4 Proteasome subunit beta type-4 1 6.77579 3.96 65.5 3 K.GVEIEGPLSAQTNWDIAHMISGFE.-

Tax_Id=10090 Gene_Symbol=Nsun2 Isoform 2 of tRNA (cytosine-5-)-methyltransferase NSUN2 Tax_Id=10090 Gene_Symbol=Nsun2 Isoform 1 of tRNA (cytosine-5-)-methyltransferase NSUN2

1 4.729884 4.12 33.8 1 R.VSSHVAATEGNPSDQSELESQMITGAGDSETAHNTENTESNEK.K11 5.106818 3.8 48.1 2 K.EDPFVFIPEDDPLFPPIEK.F

Tax_Id=10090 Gene_Symbol=Hsp90b1 Putative uncharacterized protein 1 7.497837 3.86 90.5 1 K.EEASDYLELDTIK.N

45 4.248128 4.12 36.7 1 K.KGYEVIYLTEPVDEYCIQALPEFDGK.R1 9.83665 4.42 50 1 K.KGYEVIYLTEPVDEYCIQALPEFDGKR.F1 7.49247 4.4 83.3 1 R.EATEKEFEPLLNWMK.D

Tax_Id=10090 Gene_Symbol=Bcap31 B-cell receptor-associated protein 31 Tax_Id=10090 Gene_Symbol=Bcap31 B-cell receptor-associated protein 31, isoform CRA_c

1 6.139834 4.28 55.2 1 K.GAAEDGDKLDIGNTEMKLEENK.STax_Id=10090 Gene_Symbol=Rpl13 60S ribosomal protein L13 Tax_Id=10090 Gene_Symbol=- 22 kDa protein

2 5.822288 4.46 92.3 1 R.GFSLEELR.V1 6.124732 6.56 94.7 2 K.STESLQANVQR.L

Tax_Id=10090 Gene_Symbol=Gm6921 similar to insulinoma protein Tax_Id=10090 Gene_Symbol=- similar to insulinoma protein

1 6.574386 6.56 70.3 1 K.KEAPPMEKPEVVK.T1 5.394371 4.72 75 1 K.EAPPMEKPEVVK.T

Tax_Id=10090 Gene_Symbol=Ptbp1 Polypyrimidine tract-binding protein 1 29 4.395688 4.72 38.6 1 R.KLPSDVTEGEVISLGLPFGK.V

1 4.703752 4.72 44.6 1 K.NFQNIFPPSATLHLSNIPPSVSEDDLK.STax_Id=10090 Gene_Symbol=Tuba3b;Tuba3a Tubulin alpha-3 chain

1 9.317764 4.14 66.7 1 K.TIGGGDDSFNTFFSETGAGK.H1 9.820419 4.25 85.7 2 R.AFVHWYVGEGMEEGEFSEAR.E

Tax_Id=10090 Gene_Symbol=Tuba4a Tubulin alpha-4A chain 1 7.671852 4.14 55.6 1 K.TIGGGDDSFTTFFCETGAGK.H1 9.820419 4.25 85.7 2 R.AFVHWYVGEGMEEGEFSEAR.E

Tax_Id=10090 Gene_Symbol=Zc3h15 Isoform 1 of Zinc finger CCCH domain-containing protein 15 Tax_Id=10090 Gene_Symbol=Zc3h15 Isoform 2 of Zinc finger CCCH domain-containing protein 15

1 4.258296 4.42 67.4 1 K.KKEEKEDEISLEDLIER.E1 5.614239 3.83 81.5 1 R.EVFEFRPELVNDDDEEADDTR.Y1 7.545847 3.83 59.3 1 R.EVFEFRPELVNDDDEEADDTR.Y

Tax_Id=10090 Gene_Symbol=Uqcrc1 Cytochrome b-c1 complex subunit 1, mitochondrial Tax_Id=10090 Gene_Symbol=Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 precursor

9 9.160749 3.86 48.3 4 K.VVELLADIVQNSSLEDSQIEK.E1 8.253187 4.12 86.7 3 K.VVELLADIVQNSSLEDSQIEKER.D7 5.643981 4.12 44.4 3 K.VVELLADIVQNSSLEDSQIEKER.D1 9.009972 4.72 86.2 1 R.NALVSHLDGTTPVCEDIGR.S

Tax_Id=10090 Gene_Symbol=Psmc3 26S protease regulatory subunit 6A 1 6.430658 3.8 56.6 1 K.MATVWDEAEQDGIGEEVLK.M1 9.372992 4.12 80.6 1 K.AMEVDERPTEQYSDIGGLDK.Q7 5.120281 4.12 52.9 1 K.AMEVDERPTEQYSDIGGLDK.Q

Tax_Id=10090 Gene_Symbol=Hnrnpl Putative uncharacterized protein 1 8.299521 3.86 74.1 1 R.GLIDGVVEADLVEALQEFGPISYVVVMPK.K1 9.733744 3.86 45.9 2 R.GLIDGVVEADLVEALQEFGPISYVVVMPK.K1 8.56168 3.86 42.6 1 R.GLIDGVVEADLVEALQEFGPISYVVVMPK.K

Tax_Id=10090 Gene_Symbol=Rpl5;Gm15500 60S ribosomal protein L5 22 5.021102 4.25 61.8 1 R.YLMEEDEDAYKK.Q

1 4.938812 4.72 95.5 1 K.NNVTPDMMEEMYKK.ATax_Id=10090 Gene_Symbol=Exosc6 Exosome complex exonuclease MTR3

1 8.351375 4.12 57.1 1 R.IRGPEESQPPQLYAAEDDETPAAR.DTax_Id=10090 Gene_Symbol=Sfrs7 Isoform 2 of Splicing factor, arginine/serine-rich 7 Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 4 of Splicing factor, arginine/serine-rich 7 Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 3 of Splicing factor, arginine/serine-rich 7 Tax_Id=10090 Gene_Symbol=Sfrs7 Isoform 1 of Splicing factor, arginine/serine-rich 7

1 4.595105 4.12 64.3 1 R.NPPGFAFVEFEDPRDAEDAVR.G2 5.153581 4.12 44.4 1 R.NPPGFAFVEFEDPRDAEDAVR.G

Tax_Id=10090 Gene_Symbol=0610011F06Rik UPF0585 protein C16orf13 homolog 1 7.764429 3.96 78.6 1 R.DTVLLEELGQASGLVLER.M1 7.708775 3.96 70.4 1 R.DTVLLEELGQASGLVLER.M

Tax_Id=10090 Gene_Symbol=Arl1 ADP-ribosylation factor-like protein 1 Tax_Id=10090 Gene_Symbol=Arl1 Putative uncharacterized protein

1 8.427928 3.96 87 1 K.GTGLDEAMEWLVETLK.STax_Id=10090 Gene_Symbol=Ahcyl2 20 kDa protein

1 5.937253 3.96 69.2 2 R.EIEIAEQEMPALMALR.KTax_Id=10090 Gene_Symbol=Flii Protein flightless-1 homolog

1 9.144327 4.42 47.4 1 K.NSGVPDDIFKLDDLSVLDLSHNQLTECPR.E5 4.29697 3.58 35.1 1 R.QPPMPLAEAEQLMEEWNEDLDGMEGFVLEGR.K1 8.419567 4.19 74.1 1 R.YWVPVEYEEEEKTEDKEGK.A8 6.471351 3.95 34.6 4 K.QVINEGEEPENFFWVGIGAQKPYDDDAEYMK.H

Tax_Id=10090 Gene_Symbol=Actn1 Alpha-actinin-1 1 5.549257 4.25 60 1 K.MLDAEDIVGTARPDEK.A1 7.824974 3.86 92.6 1 K.VLAVNQENEQLMEDYEK.L1 8.811826 4.03 56.5 1 K.VLAVNQENEQLMEDYEKLASDLLEWIR.R1 10.56102 5.63 88.5 3 K.KHEAFESDLAAHQDR.V1 7.984794 4.25 88.9 1 K.IDQLECDHQLIQEALIFDNK.H1 6.015697 4.25 66.7 2 K.IDQLECDHQLIQEALIFDNK.H

Tax_Id=10090 Gene_Symbol=Gys2 Glycogen [starch] synthase, liver Tax_Id=10090 Gene_Symbol=Gys2 glycogen synthase 2 Tax_Id=10090 Gene_Symbol=LOC633620 similar to Glycogen synthase 2

1 7.884814 4.46 59.3 1 R.S(79.9663)LSVTS(79.9663)LGGLPVWEAER.L1 6.399271 4.42 43.3 1 R.YLCAANIDFYNQLDKFDIDKEAGER.Q1 7.342954 4.25 78.6 1 R.GEIPDMNSILDRDDLTIMK.R

Tax_Id=10090 Gene_Symbol=Rbbp7 Histone-binding protein RBBP7 Tax_Id=10090 Gene_Symbol=Rbbp7 Retinoblastoma binding protein 7

1 5.655731 3.86 100 1 K.EMFEDTVEER.V11 4.096867 4.28 37 1 K.IGEEQSAEDAEDGPPELLFIHGGHTAK.I

Tax_Id=10090 Gene_Symbol=Ighg1 Ig gamma-1 chain C region, membrane-bound form Tax_Id=10090 Gene_Symbol=Ighg1 Ig gamma-1 chain C region secreted form Tax_Id=10090 Gene_Symbol=Ighg1 Igh protein

1 8.81442 4.28 39 2 K.VTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPR.ETax_Id=10090 Gene_Symbol=Myh10 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Myh9 14 kDa protein

1 8.519996 4.4 72.4 1 K.VEDMAELTCLNEASVLHNLK.DTax_Id=10090 Gene_Symbol=Scp2 Sterol carrier protein 2, liver

1 10.21548 3.86 86.7 1 K.AVEIVAQEMMTDLPSTFEEK.STax_Id=10090 Gene_Symbol=- Modified fragile X mental retardation protein (Fragment)

1 7.738663 3.86 95.5 1 K.DINESDEVEVYSR.ATax_Id=10090 Gene_Symbol=Larp4 La ribonucleoprotein domain family, member 4 isoform 2 Tax_Id=10090 Gene_Symbol=Larp4 La-related protein 4

1 5.197295 4.25 52.1 2 K.DLYLISQMDSDQFVPIWTVANMEEIKK.L2 6.313211 8.26 35.6 1 K.DTLNPVAVPVS(79.9663)SPTATKPSPANTASPCTSNINPPR.A

Tax_Id=10090 Gene_Symbol=Glud1 Glutamate dehydrogenase 1, mitochondrial 1 6.352309 4.4 100 1 R.GASIVEDKLVEDLK.T1 7.363399 4.4 90.9 1 R.RDDGSWEVIEGYR.A1 6.726554 3.96 100 1 R.DDGSWEVIEGYR.A1 8.485896 3.86 75 2 K.VYEGSILEADCDILIPAASEK.Q1 4.08115 3.86 49.1 1 K.VYEGSILEADCDILIPAASEK.Q

Tax_Id=10090 Gene_Symbol=Pwp1 Periodic tryptophan protein 1 homolog 1 5.902045 4.42 64.9 2 K.DTEQYEHEDFLIKPTDNLIVCGR.A

1 4.936479 6.56 60.7 1 K.GLSVSGPCGSRS(79.9663)PQQTPMES.-1 6.799504 6.56 57.1 1 K.GLSVSGPCGS(79.9663)RSPQQTPMES.-

Tax_Id=10090 Gene_Symbol=Mrpl28 39S ribosomal protein L28, mitochondrial 1 8.756161 3.8 85.7 1 R.SFVIPEAEAEWVGLTLEEALEK.Q

13 8.244256 3.8 42.6 1 R.SFVIPEAEAEWVGLTLEEALEK.QTax_Id=10090 Gene_Symbol=Arf6 ADP-ribosylation factor 6

1 6.677914 4.89 78.3 1 K.QDLPDAMKPHEIQEK.LTax_Id=10090 Gene_Symbol=Npm3 Nucleoplasmin-3 Tax_Id=10090 Gene_Symbol=LOC639633 similar to nucleophosmin/nucleoplasmin-3

1 8.514729 4.72 96 1 R.DHDNQEIAVPVANLR.LTax_Id=10090 Gene_Symbol=Caprin1 Cell cycle associated protein 1 Tax_Id=10090 Gene_Symbol=Caprin1 38 kDa protein

1 4.936807 6.56 92.3 2 R.DGYQQNFK.RTax_Id=10090 Gene_Symbol=Bclaf1 BCL2-associated transcription factor 1 isoform 3

1 6.238249 4.2 71.4 1 K.SQEEPKDTFEHDPSESIDEFNK.S1 6.427136 4.2 50 1 K.SQEEPKDTFEHDPSESIDEFNK.S3 5.305352 4.19 46.4 1 K.GRADGDWDDQEVLDYFS(79.9663)DKESAK.Q1 8.205886 3.95 72 1 R.ADGDWDDQEVLDYFS(79.9663)DKESAK.Q1 6.645221 3.95 56.9 1 R.ADGDWDDQEVLDYFS(79.9663)DKESAK.Q1 6.213866 7.25 86.4 2 K.LKELFDYS(79.9663)PPLHK.S1 4.929446 7.25 57.5 1 K.LKELFDYS(79.9663)PPLHK.S3 5.373283 4.58 59.1 1 R.GTFHDDRDDGVDYWAK.R

Tax_Id=10090 Gene_Symbol=Acaa1a;Acaa1b 3-ketoacyl-CoA thiolase B, peroxisomal 1 7.758385 3.96 78.1 1 K.DTTPDELLSAVLTAVLQDVK.L1 6.836593 3.96 53.7 1 K.DTTPDELLSAVLTAVLQDVK.L1 5.073421 4.14 81.5 1 R.DCLIPMGITSENVAER.F

Tax_Id=10090 Gene_Symbol=Acaa1a;Acaa1b 3-ketoacyl-CoA thiolase A, peroxisomal 1 7.877132 4.14 63.6 1 K.NTTPDELLSAVLTAVLQDVR.L1 6.095857 4.14 85.2 2 R.DCLTPMGMTSENVAER.F

Tax_Id=10090 Gene_Symbol=LOC100047006 similar to Ribosomal protein L7a 32 6.515301 8.22 41.5 1 R.KTCTTVAFTQVNSEDKGALAK.L

1 5.926435 4.46 88 1 K.TCTTVAFTQVNSEDK.G1 10.20986 6.56 68.8 1 K.TCTTVAFTQVNSEDKGALAK.L

Tax_Id=10090 Gene_Symbol=Gm12141 similar to Heat shock protein 1 1 7.335008 3.96 81.8 1 K.TLNDELEIIEGMK.F1 7.660267 4.25 84.6 1 K.TLNDELEIIEGMKFDR.G3 4.997611 4.25 52.1 1 K.TLNDELEIIEGMKFDR.G1 7.528364 4.14 81.8 1 K.CEFQDAYVLLSEK.K1 6.782995 4.12 71.4 1 R.IQEITEQLDITTSEYEKEK.L

Tax_Id=10090 Gene_Symbol=Lrrfip1 Putative uncharacterized protein (Fragment) 1 4.593901 4.25 78.9 1 R.EIKDSLAEVEEK.Y1 6.410612 3.86 72.5 2 K.DMLLELEEQLAESQR.Q

Tax_Id=10090 Gene_Symbol=Decr1 2,4-dienoyl-CoA reductase, mitochondrial 1 8.241056 3.96 71.4 1 R.FDGGEEVFLSGEFNSLK.K1 5.168376 3.96 100 1 K.EEWDIIEGLIR.K

Tax_Id=10090 Gene_Symbol=Myo1b 34 kDa protein 35 5.147042 4.4 35.3 1 R.NAMQIVGFLDHEAEAVLEVVAAVLK.L

Tax_Id=10090 Gene_Symbol=Gm5116 similar to ribosomal protein L23a

Tax_Id=10090 Gene_Symbol=- 17 kDa protein Tax_Id=10090 Gene_Symbol=Gm3174;LOC100046821 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=LOC100048108 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm3362 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm3940 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm8290 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm10335 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm8137;Gm8264 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm8158;Gm8112 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=LOC639294 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm6666 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Gm6003 similar to ribosomal protein L23a Tax_Id=10090 Gene_Symbol=Rpl23a;Gm10132 60S ribosomal protein L23a

1 6.206596 4.14 95.2 1 C.LAPDYDALDVANK.ITax_Id=10090 Gene_Symbol=Cald1 caldesmon 1 Tax_Id=10090 Gene_Symbol=Cald1 63 kDa protein Tax_Id=10090 Gene_Symbol=Cald1 62 kDa protein Tax_Id=10090 Gene_Symbol=Cald1 62 kDa protein

1 4.522618 4.4 65.2 1 R.SGRYEVEETEVVIK.S1 6.036907 3.96 100 1 R.YEVEETEVVIK.S1 6.044742 4.4 77.8 1 R.ASGDKEAEGAPQVEAGK.R1 5.26681 4.4 81 1 K.QQEAALELEELKK.K

Tax_Id=10090 Gene_Symbol=Cmas Isoform 1 of N-acylneuraminate cytidylyltransferase Tax_Id=10090 Gene_Symbol=Cmas Isoform 2 of N-acylneuraminate cytidylyltransferase

1 6.733219 4.12 66.7 1 R.AEHSVDIDVDIDWPIAEQR.V1 6.844402 3.86 75 1 K.EVAYLGNEVSDEECLK.R1 8.167652 4.25 84.6 1 K.EVAYLGNEVSDEECLKR.V

Tax_Id=10090 Gene_Symbol=Set;Gm9531 Isoform 1 of Protein SET Tax_Id=10090 Gene_Symbol=Gm9531 similar to protein phosphatase 2A inhibitor-2 I-2PP2A isoform 2 Tax_Id=10090 Gene_Symbol=LOC100047898 similar to protein phosphatase 2A inhibitor-2 I-2PP2A Tax_Id=10090 Gene_Symbol=Set SET translocation Tax_Id=10090 Gene_Symbol=Set SET translocation Tax_Id=10090 Gene_Symbol=Set Isoform 2 of Protein SET Tax_Id=10090 Gene_Symbol=BC085271 cDNA sequence BC085271

1 5.427119 3.96 93.8 1 R.VEVTEFEDIK.S1 5.672243 3.96 95.2 1 R.IDFYFDENPYFENK.V

Tax_Id=10090 Gene_Symbol=Inmt Indolethylamine N-methyltransferase 14 5.184483 4.58 42.4 1 K.KEPGAYDWSSIVQHACELEGDR.S

Tax_Id=10090 Gene_Symbol=Gm4852 similar to mDj4 1 9.161229 3.8 88.5 1 R.DPFSFDFFEDPFDDFFGNR.R1 5.736693 4.12 57.1 1 R.DPFSFDFFEDPFDDFFGNRR.G

Tax_Id=10090 Gene_Symbol=Usp15 Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 Tax_Id=10090 Gene_Symbol=Usp15 Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 15

1 5.931719 4.25 66.7 1 K.EHLIDELDYILLPTEGWNK.LTax_Id=10090 Gene_Symbol=Arf2 ADP-ribosylation factor 2 Tax_Id=10090 Gene_Symbol=Arf2 ADP-ribosylation factor 2 Tax_Id=10090 Gene_Symbol=Arf3 ADP-ribosylation factor 3 Tax_Id=10090 Gene_Symbol=Arf1 ADP-ribosylation factor 1

1 6.311277 4.14 80.8 1 K.QDLPNAMNAAEITDK.LTax_Id=10090 Gene_Symbol=Ephx2 Isoform 2 of Epoxide hydrolase 2

1 10.00481 3.86 73.3 2 K.GYGDSSSPPEIEEYAMELLCK.E1 7.186882 3.96 60.7 3 R.SIPVFNYQLYFQEPGVAEAELEK.N1 4.581896 3.96 54.1 1 R.SIPVFNYQLYFQEPGVAEAELEK.N

Tax_Id=10090 Gene_Symbol=Cyp2d26 Cytochrome P450 2D26 2 6.310161 4.25 40.3 2 K.ESLGEDTGFVGEVLNAIPMLLHIPGLPDK.A1 6.590086 3.96 100 1 R.DLTDAFLAEVEK.A

Tax_Id=10090 Gene_Symbol=Cyp2c54 Cytochrome P450 2C54 1 7.036241 4.72 86.4 1 K.EALVDHGDVFAGR.G1 5.331432 4.57 69 1 K.DRDFLNLLEKLDEISK.I1 5.42104 4.72 94.4 1 K.VQEEIEHVIGK.H

Tax_Id=10090 Gene_Symbol=Cald1 H-caldesmon 1 5.143467 4.4 84.2 1 R.LRLEVEGQEQER.I1 6.044742 4.4 77.8 1 R.ASGDKEAEGAPQVEAGK.R

Tax_Id=10090 Gene_Symbol=Cnbp Isoform 2 of Cellular nucleic acid-binding protein Tax_Id=10090 Gene_Symbol=Cnbp Isoform 3 of Cellular nucleic acid-binding protein

1 7.821808 3.96 95 2 K.DCDLQEDACYNCGR.GTax_Id=10090 Gene_Symbol=Rpl35a;LOC100046034;LOC100044516;Gm10214;Gm10296;Gm13911;Gm10213;Gm15434;mCG_133520 60S ribosomal protein L35a Tax_Id=10090 Gene_Symbol=LOC100044591 similar to ribosomal protein L35a Tax_Id=10090 Gene_Symbol=Gm3649 similar to ribosomal protein L35a Tax_Id=10090 Gene_Symbol=LOC100048640 similar to ribosomal protein L35a Tax_Id=10090 Gene_Symbol=Gm10247 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm10237 similar to ribosomal protein L35a

1 6.878297 4.14 92.9 1 R.DETEFYLGK.RTax_Id=10090 Gene_Symbol=Krt14 Keratin, type I cytoskeletal 14

1 5.56328 6.56 100 2 K.VTMQNLNDR.L1 7.161708 3.96 94.7 1 R.ALEEANTELEVK.I1 7.707012 4.25 85.2 1 R.ADLEMQIESLKEELAYLK.K1 5.681929 4.25 60.9 1 R.ADLEMQIESLKEELAYLK.K

Tax_Id=10090 Gene_Symbol=Ppp2r2a Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 1 6.774388 6.56 84.2 2 K.NAAQFLLSTNDK.T1 4.158661 3.96 83.3 1 K.LFEEPEDPSNR.S1 6.051218 4.4 81 1 K.DEISVDSLDFNKK.I

Tax_Id=10090 Gene_Symbol=Erp44 Endoplasmic reticulum resident protein 44 1 8.788419 4.4 85.7 1 K.SNPVHEIQSLDEVTNLDR.S1 5.693111 3.86 78.3 2 K.DDTESLEIFQNEVAR.Q

Tax_Id=10090 Gene_Symbol=Psmc5 26S protease regulatory subunit 8 Tax_Id=10090 Gene_Symbol=Psmc5 Psmc5 protein

1 11.91744 4.14 100 1 K.VPDSTYEMIGGLDK.Q1 6.334387 4.4 69 1 R.EHAPSIIFMDEIDSIGSSR.L1 5.992373 4.4 60 1 R.EHAPSIIFMDEIDSIGSSR.L

Tax_Id=10090 Gene_Symbol=Hnrnpa1l2 similar to heterogeneous nuclear ribonucleoprotein A1, isoform 1 Tax_Id=10090 Gene_Symbol=- 21 kDa protein Tax_Id=10090 Gene_Symbol=Hnrnpa1 Isoform Long of Heterogeneous nuclear ribonucleoprotein A1 Tax_Id=10090 Gene_Symbol=Hnrnpa1l2 similar to heterogeneous nuclear ribonucleoprotein A1, isoform 2 Tax_Id=10090 Gene_Symbol=Hnrnpa1 Putative uncharacterized protein

1 6.131201 4.14 100 1 K.IEVIEIMTDR.G

1 5.555144 4.89 75 2 K.RGFAFVTFDDHDSVDK.ITax_Id=10090 Gene_Symbol=Ndufv2 Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1 7.905916 4.25 73.1 1 R.DTPENNPDTPFDFTPENYKR.ITax_Id=10090 Gene_Symbol=Prss3;Gm5771;Tcrb-V20;Prss1;EG436523 protease, serine, 1

32 6.073962 4.4 44.8 1 R.LGEHNINVLEGNEQFIDAAK.I4 4.023611 4.4 47.5 1 R.LGEHNINVLEGNEQFIDAAK.I

Tax_Id=10090 Gene_Symbol=Gsta2 Glutathione S-transferase A2 Tax_Id=10090 Gene_Symbol=Gm10639 Glutathione S-transferase Tax_Id=10090 Gene_Symbol=Gsta2 21 kDa protein Tax_Id=10090 Gene_Symbol=Gsta2 21 kDa protein Tax_Id=10090 Gene_Symbol=Gm10639 hypothetical protein LOC100042314 Tax_Id=10090 Gene_Symbol=Gsta1 Glutathione S-transferase A1 Tax_Id=10090 Gene_Symbol=Gsta2 glutathione S-transferase, alpha 2 Tax_Id=10090 Gene_Symbol=Gm3776;Gsta1 Glutathione S-transferase

1 6.889247 3.96 83.3 2 K.DGNLMFDQVPMVEIDGMK.LTax_Id=10090 Gene_Symbol=Dnm1l Isoform 5 of Dynamin-1-like protein

2 4.115016 4.03 51.9 1 K.LYTDFDEIRQEIENETER.ITax_Id=10090 Gene_Symbol=Sdc4 Syndecan-4

1 7.034649 4.25 88 2 R.VPSEPKELEENEVIPK.R16 4.481447 4.25 48.9 1 R.VPSEPKELEENEVIPK.R

Tax_Id=10090 Gene_Symbol=LOC100046435 similar to ribosomal protein L6 1 7.182919 4.4 100 14 R.HQEGEIFDTEK.E1 7.457183 4.58 70.3 4 R.HQEGEIFDTEKEK.Y

Tax_Id=10090 Gene_Symbol=Gm5453 similar to ribosomal protein L27A Tax_Id=10090 Gene_Symbol=Rpl27a 60S ribosomal protein L27a

1 7.928088 6.56 90 1 R.NQSFCPTVNLDK.PTax_Id=10090 Gene_Symbol=Spna2 Spectrin alpha 2

1 5.221553 3.96 83.3 1 K.VLETAEDIQER.RTax_Id=10090 Gene_Symbol=Gm7426 Putative histone H3-like Tax_Id=10090 Gene_Symbol=- 15 kDa protein Tax_Id=10090 Gene_Symbol=Gm12657 predicted gene 12657 Tax_Id=10090 Gene_Symbol=Hist1h3a;Hist1h3i;Hist1h3h;Hist1h3g Histone H3.1 Tax_Id=10090 Gene_Symbol=Gm12260 similar to histone H3

1 5.618752 4.72 94.4 1 Q.EIAQDFKTDLR.FTax_Id=10090 Gene_Symbol=Foxo6 Foxo6 protein Tax_Id=10090 Gene_Symbol=Foxo6 Forkhead box protein O6

1 8.148067 8.8 96.2 1 R.RNAWGNLSYADLITK.A1 6.872889 8.8 82.6 1 R.RNAWGNLS(79.9663)YADLITK.A1 7.137658 6.56 86.4 2 R.NAWGNLSYADLITK.A1 5.983445 6.56 86.4 1 R.NAWGNLSY(79.9663)ADLITK.A1 6.083241 6.56 94.1 4 K.DKGDSNSSAGWK.N1 6.413917 6.56 100 7 K.DKGDSNSSAGWK.N1 6.32866 8.8 92.3 2 K.DKGDSNSSAGWKNSIR.H1 5.828032 8.8 77.8 2 K.DKGDSNSSAGWKNS(79.9663)IR.H1 9.891484 6.56 86.7 1 R.VQNEGTGKSSWWMLNPEGGK.T1 6.024244 6.56 93.3 1 K.SSWWMLNPEGGK.T1 7.479659 6.56 100 1 K.SSWWMLNPEGGK.T1 5.050571 6.56 88.9 1 K.SS(79.9663)WWMLNPEGGK.T

Tax_Id=10090 Gene_Symbol=Hnrnph2 Heterogeneous nuclear ribonucleoprotein H2 Tax_Id=10090 Gene_Symbol=Hnrnph1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Hnrnph1 Heterogeneous nuclear ribonucleoprotein H

1 8.416397 4.03 83.9 3 R.EGRPSGEAFVELESEDEVK.L1 7.361403 3.8 92 1 R.PSGEAFVELESEDEVK.L1 7.363116 4.14 88.9 1 R.STGEAFVQFASQEIAEK.A

Tax_Id=10090 Gene_Symbol=Mrps27 28S ribosomal protein S27, mitochondrial 1 6.592736 4.58 55.6 1 R.EKEEYHLADLASLMDK.A1 9.341088 4.25 85.2 3 K.EKLPACEAEDLATYEQK.L3 5.900644 4.25 55.1 1 K.EKLPACEAEDLATYEQK.L

Tax_Id=10090 Gene_Symbol=Lsm14a LSM14 homolog A 1 7.056014 4.12 67.9 1 K.DFDFESANAQFNKEEIDR.E1 7.26134 4.53 49.2 1 K.DFDFESANAQFNKEEIDREFHNK.L

Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 1 owl|S68241| immunoglobulin light chain (Mab13-1) - mouse (fragment) owl|| Immunoglobulin igg1-kappa antibody fragment fab complexed With... Tax_Id=10090 Gene_Symbol=Igk-C Kappa light chain C_region (Fragment) Tax_Id=10090 Gene_Symbol=Igk-C If kappa light chain (Fragment) Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 3 Tax_Id=10090 Gene_Symbol=Gm10883 ENSMUSG00000076577 protein Tax_Id=10090 Gene_Symbol=Gm1499 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gm10880 LOC100046793 protein Tax_Id=10090 Gene_Symbol=Igk-C Igk protein Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 2 Tax_Id=10090 Gene_Symbol=Igk Igk protein Tax_Id=10090 Gene_Symbol=Igk Anti-colorectal carcinoma light chain

1 6.467754 4.4 71.4 1 K.DSTYSMSSTLTLTKDEYER.HTax_Id=10090 Gene_Symbol=Spcs2 Signal peptidase complex subunit 2

1 6.825541 3.96 75.9 1 K.DPTGMDPDDIWQLSSSLK.RTax_Id=10090 Gene_Symbol=Rpl28;Gm15435 60S ribosomal protein L28 Tax_Id=10090 Gene_Symbol=Gm12938 similar to ribosomal protein L28 Tax_Id=10090 Gene_Symbol=Gm10051 similar to ribosomal protein L28

1 6.855937 6.56 82.4 5 K.QTYSTEPNNLK.ATax_Id=10090 Gene_Symbol=Gm5437 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm6635 hypothetical protein Tax_Id=10090 Gene_Symbol=- 15 kDa protein Tax_Id=10090 Gene_Symbol=Gm10072 hypothetical protein Tax_Id=10090 Gene_Symbol=Gm16382 hypothetical protein

1 5.976572 3.55 100 1 K.NLQTVNVDEN.-Tax_Id=10090 Gene_Symbol=Golga3 Isoform 1 of Golgin subfamily A member 3 Tax_Id=10090 Gene_Symbol=Golga3 Isoform 2 of Golgin subfamily A member 3

1 11.81892 3.96 96.4 1 R.LPDQQDTAQDASVEVNR.G1 8.224593 4.4 58.6 1 K.DVLQAAAAQHQDQNQEANGEVR.S1 4.461796 4.58 79.2 1 R.EADSREDAIHFLQNEK.I1 7.373139 4.12 85.7 1 R.RLEEDTEETSGLLEQLR.Q

10 8.080359 4.28 35.7 1 K.KLDEQMSQQPTGSQEMEDLKWELDQK.E1 6.653878 4.12 65.4 1 K.SELEMVQEDLSETQKDK.F

Tax_Id=10090 Gene_Symbol=Aldh1l1 10-formyltetrahydrofolate dehydrogenase

1 6.706494 3.96 67.9 1 K.ECDVLPDDTVSTLYNR.F1 8.253685 3.86 78.1 2 K.GSASSALELTEEELATAEAVR.S1 6.364371 3.96 77.8 1 R.ILPNVPEVEDSTDFFK.S1 6.599182 4.57 55.2 1 R.KLRGEDGESECVINYVEK.A4 4.727261 4.57 50 1 R.KLRGEDGESECVINYVEK.A1 6.885556 4.25 79.1 1 K.LRGEDGESECVINYVEK.A1 7.471783 3.86 83.3 5 R.GEDGESECVINYVEK.A

Tax_Id=10090 Gene_Symbol=Capn2 Calpain-2 catalytic subunit 1 6.425451 3.83 58.1 1 K.LEEEDEDEEDGERGCTFLVGLIQK.H6 6.551599 3.9 35.1 2 K.KADYQAVDDEIEANIEEIDANEEDIDDGFRR.L

Tax_Id=10090 Gene_Symbol=Ddx52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 29 5.327582 3.95 35.3 1 K.QDPPGIDLTNVEWLVVDESDKLFEDGK.T

1 9.580374 3.96 58.6 2 R.NSAVETVEQELLFVGSETGK.LTax_Id=10090 Gene_Symbol=Aldh2 Aldehyde dehydrogenase, mitochondrial

32 8.02772 4.57 35.6 1 R.KTFPTVNPSTGEVICQVAEGNKEDVDK.A1 9.321492 3.96 91.3 1 R.TFVQENVYDEFVER.S

Tax_Id=10090 Gene_Symbol=Scyl2 Isoform 2 of SCY1-like protein 2 1 8.210492 4.14 95.8 1 R.SLDIGNQMSTSEETK.V1 8.346383 4.25 63.3 1 K.VFNNIGADLLSGSESENREDGMQGK.Q

Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L3 isoform 2 1 10.09677 7.25 77.8 1 K.DDASKPVHLTAFLGYK.A1 7.050005 7.25 56.5 1 K.DDASKPVHLTAFLGYK.A1 6.3805 4.14 93.8 3 K.NNASTDYDLSDK.S1 7.78947 4.14 90 16 K.NNASTDYDLSDK.S

Tax_Id=10090 Gene_Symbol=Kctd2 BTB/POZ domain-containing protein KCTD2 Tax_Id=10090 Gene_Symbol=Kctd2 potassium channel tetramerisation domain containing 2 Tax_Id=10090 Gene_Symbol=LOC100046153 similar to KIAA0176 Tax_Id=10090 Gene_Symbol=Kctd2 Potassium channel tetramerisation domain containing 2 Tax_Id=10090 Gene_Symbol=Kctd2 Potassium channel tetramerisation domain containing 2

1 9.73933 3.96 82.1 1 R.VLQCQEEELTQMVSTMSDGWK.FTax_Id=10090 Gene_Symbol=Gstz1 Maleylacetoacetate isomerase Tax_Id=10090 Gene_Symbol=Gstz1 Brain cDNA, clone MNCb-6148, similar to Mus musculus glutathione transferase zeta 1 (maleylacetoacetate isomerase) (Gstz1), mRNA

1 7.267852 4.14 74.1 4 K.DGGQQFTEEFQTLNPMK.QTax_Id=10090 Gene_Symbol=Prdx6 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Prdx6 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Prdx6 22 kDa protein Tax_Id=10090 Gene_Symbol=Prdx6 Peroxiredoxin-6

1 7.040293 4.14 83.3 1 R.DLAILLGMLDPVEK.DTax_Id=10090 Gene_Symbol=Dstn Destrin

1 8.082997 4.72 100 5 K.HEYQANGPEDLNR.TTax_Id=10090 Gene_Symbol=Ablim1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Ablim1 49 kDa protein Tax_Id=10090 Gene_Symbol=Ablim1 52 kDa protein Tax_Id=10090 Gene_Symbol=Ablim1 84 kDa protein Tax_Id=10090 Gene_Symbol=Ablim1 Ablim1 protein Tax_Id=10090 Gene_Symbol=Ablim1 87 kDa protein Tax_Id=10090 Gene_Symbol=Ablim1 77 kDa protein Tax_Id=10090 Gene_Symbol=Ablim1 80 kDa protein

Tax_Id=10090 Gene_Symbol=Ablim1 Isoform 3 of Actin-binding LIM protein 1 Tax_Id=10090 Gene_Symbol=Ablim1 Isoform 1 of Actin-binding LIM protein 1 Tax_Id=10090 Gene_Symbol=Ablim1 Isoform 2 of Actin-binding LIM protein 1 Tax_Id=10090 Gene_Symbol=Ablim1 Ablim1 protein

1 5.380269 4.28 49.3 1 K.AIYDIERPDLITYEPFYTSGYEDKQER.Q1 8.693713 4.89 45.6 1 R.HLAPEVFWEIFGMSIQEFDKLPLWR.R

no description1 9.646843 4.25 89.7 1 R.NLDLDSIIAEVKAQYEEIAQR.S1 7.566906 4.25 58.2 3 R.NLDLDSIIAEVKAQYEEIAQR.S1 5.298876 6.56 94.4 2 R.NTKQEIAEINR.M1 4.187907 4.72 74.3 1 K.NKLEGLEDALQK.A

Tax_Id=10090 Gene_Symbol=Cct5 T-complex protein 1 subunit epsilon Tax_Id=10090 Gene_Symbol=Cct5 22 kDa protein

1 8.249551 3.64 75.8 1 K.SQDDEIGDGTTGVVVLAGALLEEAEQLLDR.G1 6.729468 4.4 100 2 R.DVDFELIKVEGK.V

Tax_Id=10090 Gene_Symbol=Bckdha branched chain keto acid dehydrogenase E1, alpha polypeptide 1 9.141993 4.14 88.5 2 R.DYPLELFMSQCYGNVNDPGK.G1 7.074456 3.96 87 1 R.QYLLNQGWWDEEQEK.A

Tax_Id=10090 Gene_Symbol=Gm6139 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Gm8225 hypothetical protein

1 4.905957 4.72 94.4 1 K.AEDKEWIPVTK.L1 6.655554 5.63 94.4 1 K.SPYQEFTDHLVK.T

Tax_Id=10090 Gene_Symbol=Ywhah Putative uncharacterized protein 1 7.661809 4.4 84.6 3 R.LAEQAERYDDMASAMK.A1 6.424296 4.4 76.2 1 R.LAEQAERYDDMASAMK.A

Tax_Id=10090 Gene_Symbol=Lonp1 Lon protease homolog Tax_Id=10090 Gene_Symbol=Lonp1 Lon protease homolog, mitochondrial

1 6.461951 3.8 70.8 2 R.QLEVEPEGLEPEAEK.Q31 4.37532 4.03 39.1 1 K.EVEDELGPKPQLEMVTEAATDTSK.E22 4.469628 4.03 32.9 1 R.VVDNPIYLSDMGAALTGAESHELQDVLEETNILK.R

Tax_Id=10090 Gene_Symbol=Gm5513 similar to eukaryotic initiation factor 4AI isoform 1 1 8.322711 3.96 100 1 K.MFVLDEADEMLSR.G1 8.789566 4.72 95.8 1 R.DFTVSAMHGDMDQK.E1 9.108422 4.89 80.8 1 R.DFTVSAMHGDMDQKER.D1 6.507654 4.89 64.4 1 R.DFTVSAMHGDMDQKER.D

Tax_Id=10090 Gene_Symbol=Akr1d1 3-oxo-5-beta-steroid 4-dehydrogenase 1 5.77327 4.28 43.1 2 R.IKENFQIFDFSLTEEEMKDIDALNK.N

Tax_Id=10090 Gene_Symbol=Por 31 kDa protein 1 12.95715 3.69 96.9 1 R.IFELGLGDDDGNLEEDFITWR.E1 6.154703 3.69 59.6 1 R.IFELGLGDDDGNLEEDFITWR.E

Tax_Id=10090 Gene_Symbol=Sfrs2 Splicing factor, arginine/serine-rich 2 Tax_Id=10090 Gene_Symbol=Sfrs2 Putative uncharacterized protein

1 8.685083 3.8 92.6 1 R.DAEDAMDAMDGAVLDGR.ETax_Id=10090 Gene_Symbol=Cbx3 Chromobox protein homolog 3 Tax_Id=10090 Gene_Symbol=Cbx3 8 kDa protein Tax_Id=10090 Gene_Symbol=- similar to Chromobox homolog 3 Tax_Id=10090 Gene_Symbol=LOC633016 similar to Chromobox homolog 3 (HP1 gamma homolog, Drosophila) isoform 2 Tax_Id=10090 Gene_Symbol=LOC632383 similar to Chromobox homolog 3

Tax_Id=10090 Gene_Symbol=Gm6901 similar to Chromobox homolog 3 Tax_Id=10090 Gene_Symbol=Gm5792 similar to Chromobox homolog 3 Tax_Id=10090 Gene_Symbol=Gm5196 similar to Chromobox homolog 3

1 7.454795 4.12 100 2 K.KVEEAEPEEFVVEK.VTax_Id=10090 Gene_Symbol=Gm5566 similar to nucleoside diphosphate kinase B

1 6.483158 4.72 95.8 3 R.NIIHGSDSVESAEK.E1 6.346973 4.72 65.9 6 R.NIIHGSDSVESAEK.E

Tax_Id=10090 Gene_Symbol=Scp2 Isoform SCP2 of Non-specific lipid-transfer protein 1 6.112725 4.4 94.4 1 K.KLEEEGEQFVK.K

Tax_Id=10090 Gene_Symbol=Ppa1 Inorganic pyrophosphatase 1 5.150344 4.12 51.7 1 K.VIAINVDDPDAANYKDISDVER.L

Tax_Id=10090 Gene_Symbol=Mtif3 Translation initiation factor IF-3, mitochondrial 1 9.627267 4.4 82.1 1 R.NTSSEPPEYQLMTGEQIHQER.L

Tax_Id=10090 Gene_Symbol=Vapa Vesicle-associated membrane protein-associated protein A 1 9.740323 4.25 78.6 1 R.CVFEMPNENDKLNDMEPSK.A

Tax_Id=10090 Gene_Symbol=Gstp2 Glutathione S-transferase P 2 Tax_Id=10090 Gene_Symbol=Gm3934;LOC100046536 similar to glutathione S-transferase pi class A

1 7.437435 4.14 92.6 2 K.FEDGDLTLYQSNAILR.H1 6.596043 4.14 62.7 1 K.FEDGDLTLYQSNAILR.H

Tax_Id=10090 Gene_Symbol=Nedd4 Nedd4 protein 1 6.194222 3.86 73.9 2 R.LDLPPYESFDELWDK.L

Tax_Id=10090 Gene_Symbol=Rpl17 60S ribosomal protein L17 Tax_Id=10090 Gene_Symbol=Gm6133 EG620155 protein Tax_Id=10090 Gene_Symbol=LOC100048040 similar to RPL17 protein Tax_Id=10090 Gene_Symbol=Gm10166 similar to Ac2-210 isoform 2 Tax_Id=10090 Gene_Symbol=LOC100045527;Rpl17;Gm10223 ribosomal protein L17 Tax_Id=10090 Gene_Symbol=Gm10166 similar to Ac2-210 isoform 1 Tax_Id=10090 Gene_Symbol=LOC545379 similar to Rpl17 protein Tax_Id=10090 Gene_Symbol=LOC100045527 similar to Ac2-210 isoform 2 Tax_Id=10090 Gene_Symbol=Gm10223 similar to Rpl17 protein isoform 2 Tax_Id=10090 Gene_Symbol=Gm10362 similar to Rpl17 protein Tax_Id=10090 Gene_Symbol=Gm10164 similar to Rpl17 protein Tax_Id=10090 Gene_Symbol=Gm10268 similar to Rpl17 protein

1 4.939988 4.4 82.6 1 K.EQIVPKPEEEVAQK.KTax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-2 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-9 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 similar to UDP-glucuronosyltransferase 1A8 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A1 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-7C Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glycosyltransferase 1 family, polypeptide A10 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A6B Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-1 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5;Ugt1a6a UDP-glucuronosyltransferase 1-6

1 9.64318 3.96 83.3 1 R.GAGVTLNVLEMTADDLENALK.T1 9.121055 4.4 96.3 1 K.DRPIEPLDLAVFWVEYVMR.H1 6.722039 4.4 54.4 1 K.DRPIEPLDLAVFWVEYVMR.H

Tax_Id=10090 Gene_Symbol=Plin2 Perilipin-2

1 6.26367 4.46 100 1 K.DSVASTVSGVVDK.T1 9.520053 4.42 77.8 1 R.SIGYDDTDESHCVEHIESR.T

Tax_Id=10090 Gene_Symbol=Mrps22 28S ribosomal protein S22, mitochondrial 1 6.316759 4.58 45.5 1 R.DLVDDATSLVQLYHMLHPDGQSAQEAK.E

Tax_Id=10090 Gene_Symbol=Tyms Thymidylate synthase 1 7.52568 4.58 52.5 2 R.HFGAEYKDMDSDYSGQGVDQLQK.V1 7.592399 3.96 88.9 1 K.DMDSDYSGQGVDQLQK.V

Tax_Id=10090 Gene_Symbol=Caprin1 Cell cycle associated protein 1 1 8.783781 4.84 84 1 R.LNEQYEHASIHLWDLLEGK.E1 8.155943 4.84 56.9 1 R.LNEQYEHASIHLWDLLEGK.E

Tax_Id=10090 Gene_Symbol=Arl8a ADP-ribosylation factor-like protein 8A Tax_Id=10090 Gene_Symbol=Arl8a Protein

1 5.774099 4.25 87 2 R.DLAGALDEKELIEK.MTax_Id=10090 Gene_Symbol=Actn4 15 kDa protein

1 5.265406 5.8 87.5 5 R.HRPELIEYDK.LTax_Id=10090 Gene_Symbol=Hyou1 Hypoxia up-regulated protein 1

1 5.580517 3.86 78.9 1 R.VEFEELCADLFDR.V1 8.363174 3.69 72.4 2 R.VESVFETLVEDSPEEESTLTK.L1 8.784073 4.12 69.2 1 K.LYQPEYQEVSTEEQREEISGK.L1 6.433575 3.86 68 1 R.LIPEMDQVFTEVEMTTLEK.V

Tax_Id=10090 Gene_Symbol=Acsl1 Long-chain-fatty-acid--CoA ligase 1 Tax_Id=10090 Gene_Symbol=Acsl1 78 kDa protein Tax_Id=10090 Gene_Symbol=Acsl1 acyl-CoA synthetase long-chain family member 1

1 8.632672 4.25 80.8 1 R.SAVLEDDKLLVYYYDDVR.T1 7.068574 4.14 88.9 1 K.EVAELAECIGSGLIQK.G1 6.941803 4.89 78.3 1 R.TAEALDKDGWLHTGDIGK.W

Tax_Id=10090 Gene_Symbol=Srp68 Signal recognition particle 68 kDa protein Tax_Id=10090 Gene_Symbol=Srp68 Signal recognition particle 68 Tax_Id=10090 Gene_Symbol=Srp68 Signal recognition particle 68

18 4.983601 4.12 37.8 1 R.IFLLGLADNEAAIVQAESEETKER.L1 6.314388 3.86 75.9 1 R.LYDIILQNLVELLQLPGLEEDR.T1 5.102246 3.86 42.9 1 R.LYDIILQNLVELLQLPGLEEDR.T

Tax_Id=10090 Gene_Symbol=Aatf Isoform 1 of Protein AATF Tax_Id=10090 Gene_Symbol=Aatf Isoform 2 of Protein AATF

1 4.993258 4.19 56.1 1 R.VIDRFDEGEEEKDDLAVSSIR.K1 5.570643 3.95 54.7 1 R.DLDEEIFDDDDFYHQLLR.E

Tax_Id=10090 Gene_Symbol=Acadm Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 1 4.712218 3.96 44.2 1 K.AFAGDIANQLATDAVQIFGGYGFNTEYPVEK.L

Tax_Id=10090 Gene_Symbol=Tmem49 Transmembrane protein 49 1 5.603052 3.79 38 1 R.LSGAEPDDEEYQEFEEMLEHAEAAQDFASR.A

Tax_Id=10090 Gene_Symbol=Mrps7 28S ribosomal protein S7, mitochondrial 1 6.680186 4.73 53.5 1 R.KPVAELTEEEKYDQELKK.T

Tax_Id=10090 Gene_Symbol=Hspd1 Isoform 2 of 60 kDa heat shock protein, mitochondrial 1 6.782995 4.12 71.4 1 R.IQEITEQLDITTSEYEKEK.L

Tax_Id=10090 Gene_Symbol=Mrpl24 39S ribosomal protein L24, mitochondrial 1 5.254602 3.86 70.8 1 K.TLEEDVMEAMGIQETR.R1 6.49045 3.86 67.4 2 K.TLEEDVMEAMGIQETR.R

Tax_Id=10090 Gene_Symbol=Gm7263;LOC676847 similar to Rps15a protein

Tax_Id=10090 Gene_Symbol=Rps15a 8 kDa protein Tax_Id=10090 Gene_Symbol=Rps15a 12 kDa protein Tax_Id=10090 Gene_Symbol=Rps15a 8 kDa protein Tax_Id=10090 Gene_Symbol=LOC100044556 similar to hCG1994130 Tax_Id=10090 Gene_Symbol=Gm13253 similar to hCG1994130 Tax_Id=10090 Gene_Symbol=Rps15a 40S ribosomal protein S15a

1 8.465011 4.84 100 1 K.HGYIGEFEIIDDHR.A1 5.154336 4.84 76.3 1 K.HGYIGEFEIIDDHR.A

Tax_Id=10090 Gene_Symbol=Rpl18a 60S ribosomal protein L18a Tax_Id=10090 Gene_Symbol=Gm15427 ribosomal protein L18A family member Tax_Id=10090 Gene_Symbol=Rpl18a Rpl18a protein

1 6.469211 6.56 80 1 R.DLTTAGAVTQCYR.DTax_Id=10090 Gene_Symbol=Gm6457;Rsl24d1 Probable ribosome biogenesis protein RLP24 Tax_Id=10090 Gene_Symbol=Rsl24d1 Putative uncharacterized protein

1 7.663327 3.96 65 1 K.ELTVDNSFEFEK.RTax_Id=10090 Gene_Symbol=Gm4987 MCG49690 Tax_Id=10090 Gene_Symbol=Rpl32 60S ribosomal protein L32

1 5.023663 4.46 100 2 K.ELEVLLMCNK.STax_Id=10090 Gene_Symbol=Mrpl54 39S ribosomal protein L54, mitochondrial

1 4.235843 4.4 87.5 8 K.KLEELEPESR.ETax_Id=10090 Gene_Symbol=Ap1b1 adaptor protein complex AP-1, beta 1 subunit Tax_Id=10090 Gene_Symbol=Ap1b1 Putative uncharacterized protein

2 5.810874 4.14 87.5 1 K.DCEDPNPLIR.A1 7.128848 4.25 48.5 1 R.LASQANIAQVLAELKEYATEVDVDFVR.K1 7.606247 4.03 45.6 1 R.IDNADELLESFLEGFHDESTQVQLQLLTAIVK.L

Tax_Id=10090 Gene_Symbol=Cald1 89 kDa protein 1 4.522618 4.4 65.2 1 R.SGRYEVEETEVVIK.S1 6.036907 3.96 100 1 R.YEVEETEVVIK.S1 5.143467 4.4 84.2 1 R.LRLEVEGQEQER.I1 6.044742 4.4 77.8 1 R.ASGDKEAEGAPQVEAGK.R1 5.26681 4.4 81 1 K.QQEAALELEELKK.K

Tax_Id=10090 Gene_Symbol=Cyp2d10 Cytochrome P450 2D10 Tax_Id=10090 Gene_Symbol=Cyp2d10 57 kDa protein

1 6.105293 3.96 55.6 1 K.VLEDSLTEISGLIPEVLNMFPILLR.I1 6.611782 4.14 95 2 R.NLTDAFLAEIEK.V

Tax_Id=10090 Gene_Symbol=Cyp2c37 Cytochrome P450 2C37 1 4.978395 4.89 78 1 K.IKEHEESLDVTIPR.D1 8.734098 3.96 86.2 2 R.DFIDYFLINGGQEDGNQPLQNR.L1 7.538657 3.96 50.7 1 R.DFIDYFLINGGQEDGNQPLQNR.L

Tax_Id=10090 Gene_Symbol=Dlst Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 1 9.033238 3.96 51.5 2 K.NDVITVQTPAFAESVTEGDVR.W1 8.089745 4.14 95 1 R.NVETMNYADIER.T

Tax_Id=10090 Gene_Symbol=Psmd4 Isoform Rpn10E of 26S proteasome non-ATPase regulatory subunit 4 4 5.931435 4.12 48 1 K.EKVNVDIINFGEEEVNTEK.L

Tax_Id=10090 Gene_Symbol=Psma6 Proteasome subunit alpha type-6 1 9.557679 4.25 80 1 R.ILTEAEIDAHLVALAERD.-

11 5.177797 4.25 52.1 1 R.ILTEAEIDAHLVALAERD.-Tax_Id=10090 Gene_Symbol=Mrps34 28S ribosomal protein S34, mitochondrial

1 5.043071 4.58 55.6 1 K.HEEEAFTAFTAKPEDR.LTax_Id=10090 Gene_Symbol=Psmd2 26S proteasome non-ATPase regulatory subunit 2

1 5.652082 4.11 45.5 2 R.DAGEKDKEQELSEEDKQLQDELEMLVER.L1 6.132745 4.11 37.6 1 R.DAGEKDKEQELSEEDKQLQDELEMLVER.L8 6.785094 4.42 47.9 1 R.HLAGEVAKEWQELDDAEK.A2 5.253364 3.96 67.7 1 K.GEAIEAILAALEVVSEPFR.S1 6.339679 3.96 56.4 1 K.GEAIEAILAALEVVSEPFR.S

Tax_Id=10090 Gene_Symbol=Fxr1 Isoform G of Fragile X mental retardation syndrome-related protein 1 1 11.67368 4.25 100 1 K.DVHEDSLTVVFENNWQPER.Q2 6.526842 4.25 48.2 2 K.DVHEDSLTVVFENNWQPER.Q1 6.275707 4.25 95.8 1 K.KEISEGDEVEVYSR.A1 6.905198 3.86 95.2 1 K.EISEGDEVEVYSR.A1 5.857449 4.14 100 2 R.GFLEFVEDFIQVPR.N2 7.020724 4.14 62.2 1 R.GFLEFVEDFIQVPR.N

Tax_Id=10090 Gene_Symbol=Eif3m Eukaryotic translation initiation factor 3 subunit M Tax_Id=10090 Gene_Symbol=Eif3m Eukaryotic translation initiation factor 3, subunit M

1 7.48552 3.69 39.1 1 K.EISFDTMQQELQIGADDVEAFVIDAVR.TTax_Id=10090 Gene_Symbol=Stard10 PCTP-like protein

2 6.368962 4.12 43.5 1 R.MECCDVPAETLYDVLHDIEYR.KTax_Id=10090 Gene_Symbol=Mrps2 28S ribosomal protein S2, mitochondrial

1 7.911756 3.96 70.6 1 K.VTGAPVPAVSEPQDGDDFQSR.ITax_Id=10090 Gene_Symbol=- 22 kDa protein

1 7.220628 4.89 80.8 1 K.RGFAFVTFDDHDTVDK.I1 5.889255 4.89 73.8 1 K.RGFAFVTFDDHDTVDK.I1 7.91624 4.4 95.8 1 R.GFAFVTFDDHDTVDK.I1 6.858712 4.4 61.5 1 R.GFAFVTFDDHDTVDK.I

Tax_Id=10090 Gene_Symbol=Rbm3 Putative RNA-binding protein 3 1 6.161673 4.46 89.5 2 R.DYSGSQGGYDR.Y

Tax_Id=10090 Gene_Symbol=Ptcd3 Putative uncharacterized protein 2 4.900556 3.89 39.7 3 K.DIAEPHIPCLMPEYFEPQIEDVSEAALEER.I1 5.609831 4.89 57.1 1 R.DKHPPELQVAFADCAADIK.S

Tax_Id=10090 Gene_Symbol=Rangap1 Ran GTPase-activating protein 1 Tax_Id=10090 Gene_Symbol=Rangap1 RAN GTPase activating protein 1

1 6.80694 4.19 58.3 1 K.LNTAEDAKDVIKEIEEFDGLEALR.L1 6.588656 4.12 77.5 1 K.DVIKEIEEFDGLEALR.L1 8.908877 4.25 89.7 1 R.DAALVVAEAVADKAELEK.L

no description1 7.21702 10.06 94.7 1 R.SGGGGGGGFGR.V1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T1 5.514476 4.25 60 1 R.NLDLDSIIAEVKAQYEEIANR.S

Tax_Id=10090 Gene_Symbol=Gm12620 Putative uncharacterized protein (Fragment) Tax_Id=10090 Gene_Symbol=Gm12623 similar to Poly A binding protein, cytoplasmic 4 isoform 1

1 7.844271 4.72 95.8 2 K.GYAFVHFETQEAADK.A1 8.076706 4.89 59.2 1 K.GYAFVHFETQEAADKAIEK.M1 10.52515 4.25 96.4 1 K.NFGEEVDDGNLKELFSQFGK.T1 5.921812 4.25 54.7 1 K.NFGEEVDDGNLKELFSQFGK.T

Tax_Id=10090 Gene_Symbol=Farsa Phenylalanyl-tRNA synthetase alpha chain

Tax_Id=10090 Gene_Symbol=Farsa Farsla protein 1 5.638709 4.4 83.3 1 R.VVDSIEDEVQKR.L

37 5.183124 4.89 35.9 1 R.DQHDTFFLRDPAEALQLPMGYVQR.VTax_Id=10090 Gene_Symbol=Fgb Fibrinogen beta chain

1 7.878429 3.86 67.9 1 K.ENENVINEYSSILEDQR.L1 6.143432 3.96 86.4 1 R.MGPTELLIEMEDWK.G1 5.270053 4.25 67.4 2 R.MGPTELLIEMEDWKGDK.V

Tax_Id=10090 Gene_Symbol=Dnajb6 Isoform A of DnaJ homolog subfamily B member 6 Tax_Id=10090 Gene_Symbol=Dnajb6 Isoform B of DnaJ homolog subfamily B member 6

1 7.516807 4.03 56.9 2 R.EFFGGRDPFSFDFFEDPFDDFFGNR.R1 9.161229 3.8 88.5 1 R.DPFSFDFFEDPFDDFFGNR.R1 5.736693 4.12 57.1 1 R.DPFSFDFFEDPFDDFFGNRR.G

Tax_Id=10090 Gene_Symbol=Sfrs6 arginine/serine-rich splicing factor 6 1 9.152946 4.03 89.7 3 K.NGYGFVEFEDSRDADDAVYELNSK.E1 7.992976 4.03 47.8 1 K.NGYGFVEFEDSRDADDAVYELNSK.E1 8.468709 3.96 94.7 1 R.DADDAVYELNSK.E

Tax_Id=10090 Gene_Symbol=Mrpl46 39S ribosomal protein L46, mitochondrial 1 4.749955 3.96 50.9 1 K.ALTPLQEEMAGLLQQIEVER.S

Tax_Id=10090 Gene_Symbol=Thoc4 Isoform 1 of THO complex subunit 4 Tax_Id=10090 Gene_Symbol=Refbp2 RNA and export factor binding protein 2 Tax_Id=10090 Gene_Symbol=Refbp2 Isoform 2 of RNA and export factor-binding protein 2 Tax_Id=10090 Gene_Symbol=Refbp2 Isoform 1 of RNA and export factor-binding protein 2 Tax_Id=10090 Gene_Symbol=Thoc4 Isoform 2 of THO complex subunit 4

1 11.29896 3.96 83.3 1 K.QQLSAEELDAQLDAYNAR.MTax_Id=10090 Gene_Symbol=LOC635326 similar to hCG2028724

1 5.3949 6.56 88.9 1 K.NFGIGQDIQPK.RTax_Id=10090 Gene_Symbol=Sod1 Superoxide dismutase [Cu-Zn]

1 5.472766 4.14 88.9 1 K.DGVANVSIEDR.VTax_Id=10090 Gene_Symbol=Psmd1 26S proteasome non-ATPase regulatory subunit 1 Tax_Id=10090 Gene_Symbol=Psmd1 111 kDa protein

1 6.937254 3.95 45.2 1 K.LNAVVNDFWAEISESVDKIEVLYEDEGFR.S1 10.19907 4.4 89.7 1 K.NAQAIEDMVGYAQETQHEK.I1 4.215299 4.12 69.4 1 K.DTSEDVEELVEPVAAHGPK.I

Tax_Id=10090 Gene_Symbol=Taf15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor Tax_Id=10090 Gene_Symbol=Taf15 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Taf15 62 kDa protein

4 7.099924 3.89 29.4 1 R.DYGPRPDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFK.QTax_Id=10090 Gene_Symbol=Prpf31 Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp31 Tax_Id=10090 Gene_Symbol=Prpf31 Isoform 3 of U4/U6 small nuclear ribonucleoprotein Prp31

1 6.682764 4.4 72.7 1 K.VGYELKDEIER.K1 8.554687 4.12 78.6 1 R.MSFGEIEEDAYQEDLGFSLGHLGK.S1 7.105852 4.12 51.6 2 R.MSFGEIEEDAYQEDLGFSLGHLGK.S

no description1 9.512419 4.25 85.7 2 R.LQLETEIEALKEELLFMK.K1 6.551979 4.46 100 1 R.QAQEYEALLNIK.V

Tax_Id=10090 Gene_Symbol=Prmt1 Isoform 1 of Protein arginine N-methyltransferase 1 Tax_Id=10090 Gene_Symbol=Prmt1 Prmt1 protein Tax_Id=10090 Gene_Symbol=Prmt1 41 kDa protein

Tax_Id=10090 Gene_Symbol=Prmt1 Isoform 3 of Protein arginine N-methyltransferase 1 Tax_Id=10090 Gene_Symbol=Prmt1 Isoform 2 of Protein arginine N-methyltransferase 1

1 7.085578 4.4 94.7 1 K.GKVEEVELPVEK.V1 5.531974 4.72 82.6 1 R.DKWLAPDGLIFPDR.A

Tax_Id=10090 Gene_Symbol=Capza1 F-actin-capping protein subunit alpha-1 Tax_Id=10090 Gene_Symbol=Capza1 F-actin capping protein alpha-1 subunit Tax_Id=10090 Gene_Symbol=Gm3608 similar to Capping protein (actin filament) muscle Z-line, alpha 1 Tax_Id=10090 Gene_Symbol=Capza1 Putative uncharacterized protein

1 8.496123 4.25 69 1 K.IEGYDDQVLITEHGDLGNSR.F1 5.187169 4.25 54.5 1 K.IEGYDDQVLITEHGDLGNSR.F

Tax_Id=10090 Gene_Symbol=Rpl7 60S ribosomal protein L7 Tax_Id=10090 Gene_Symbol=Rpl7 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gm5045 similar to 60S ribosomal protein L7 isoform 2

1 6.329669 4.89 77.4 1 K.TTHFVEGGDAGNREDQINR.L33 4.433439 4.89 50.6 1 K.TTHFVEGGDAGNREDQINR.L

Tax_Id=10090 Gene_Symbol=Tagln2 Transgelin-2 1 6.011499 4.14 75 2 R.DDGLFSGDPNWFPK.K

Tax_Id=10090 Gene_Symbol=Chd4 Chromodomain-helicase-DNA-binding protein 4 Tax_Id=10090 Gene_Symbol=Chd4 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Chd4 MKIAA4075 protein

1 6.87089 3.95 49.2 1 K.SSAQLLEDWGMEDIDHVFSEEDYR.T1 5.826113 3.96 80 1 R.ENEFSFEDNAIR.G2 7.857689 4.42 48.3 2 R.FHNLEGFLEEFADIAKEDQIK.K6 4.541286 4.25 58.5 1 K.MLDLLEDFLEHEGYK.Y1 5.665415 4.42 54.9 1 K.MLDLLEDFLEHEGYKYER.I5 4.738763 4.16 35.4 1 K.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.A

51 6.265984 4.16 34.7 1 K.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.A2 4.893035 4.03 42.9 1 R.LLDRNQDETEDTELQGMNEYLSSFK.V1 8.459036 3.8 75.9 2 R.NQDETEDTELQGMNEYLSSFK.V

Tax_Id=10090 Gene_Symbol=Eif3b Eif3b protein Tax_Id=10090 Gene_Symbol=Eif3b 109 kDa protein

1 5.985964 4.12 50 1 R.GHPSAGAEEEGGSDGSAAEAEPR.A2 5.24246 4.12 44.1 1 K.DRPQEADGIDSVIVVDNVPQVGPDR.L1 9.728456 4.14 78.6 1 K.DFSWSPGGNIIAFWVPEDK.D

Tax_Id=10090 Gene_Symbol=Nop58 Nucleolar protein 58 1 10.19925 3.86 75 1 K.NYASASLSEFLSEEVEAEVK.A1 10.02678 3.96 93.1 1 R.YDAFGEDSSSAMGIENR.A

Tax_Id=10090 Gene_Symbol=Tor1aip1 Torsin-1A-interacting protein 1 Tax_Id=10090 Gene_Symbol=Tor1aip1 Lamina-associated polypeptide 1B

1 8.648098 3.86 91.3 2 R.FSEEPAEVYGDFEPR.A1 7.19132 4.42 69.1 2 K.AAQDSDLVKHEVDQELTDGFK.N

Tax_Id=10090 Gene_Symbol=LOC100048323 similar to RIKEN cDNA C730004C24 gene isoform 2 Tax_Id=10090 Gene_Symbol=Cyp2c69 similar to RIKEN cDNA C730004C24 gene isoform 2 Tax_Id=10090 Gene_Symbol=Cyp2c69 cytochrome P450, family 2, subfamily c, polypeptide 69 Tax_Id=10090 Gene_Symbol=LOC100048323 similar to RIKEN cDNA C730004C24 gene isoform 1

1 6.362267 6.56 100 1 K.DKDFLSLIGK.V1 7.527198 4.89 87 2 K.IKEHEESLDVTNPR.D1 5.355848 4.89 67.4 19 K.IKEHEESLDVTNPR.D

1 5.566691 4.46 100 1 R.DFIDYFLIQR.RTax_Id=10090 Gene_Symbol=Gm4949 similar to glutamine synthetase

1 4.82671 5.63 92.3 3 R.DIVEAHYR.A1 7.919165 4.14 87.5 1 R.TCLLNETGDEPFQYK.N1 6.857695 4.14 84 1 R.TCLLNETGDEPFQYKN.-

Tax_Id=10090 Gene_Symbol=Tfg Trk-fused Tax_Id=10090 Gene_Symbol=Tfg Trk-fused gene Tax_Id=10090 Gene_Symbol=Tfg Trk-fused gene Tax_Id=10090 Gene_Symbol=Tfg Trk-fused

1 10.36475 3.96 73.5 1 K.NVMSAFGLTDDQVSGPPSAPTEDR.S1 5.230842 3.96 67.2 2 K.NVMSAFGLTDDQVSGPPSAPTEDR.S

Tax_Id=10090 Gene_Symbol=Uox Uricase 1 6.03134 4.14 100 2 K.NDEVEFVR.T1 6.769864 4.72 90.9 2 R.RDVDFEAIWGAVR.D1 6.152906 4.14 100 1 R.DVDFEAIWGAVR.D

Tax_Id=10090 Gene_Symbol=Polr2c DNA-directed RNA polymerase II subunit RPB3 Tax_Id=10090 Gene_Symbol=Polr2c polymerase (RNA) II (DNA directed) polypeptide C Tax_Id=10090 Gene_Symbol=Polr2c Putative uncharacterized protein

1 5.078132 4.12 57.1 1 R.NRDNDPNDYVEQDDILIVK.LTax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph aspartate beta-hydroxylase isoform 2 Tax_Id=10090 Gene_Symbol=Asph 78 kDa protein Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase, isoform CRA_d Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartate-beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartyl/asparaginyl beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Aspartly beta-hydroxylase Tax_Id=10090 Gene_Symbol=Asph Cardiac junctate 3 Tax_Id=10090 Gene_Symbol=Asph Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Asph Asph protein

1 10.68749 3.69 89.7 2 K.LGVYDADGDGDFDVDDAK.VTax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein (Fragment) Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Spin1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Spin1;LOC100046080 Isoform 2 of Spindlin-1 Tax_Id=10090 Gene_Symbol=Spin1;LOC100046080 Isoform 1 of Spindlin-1

1 9.352684 4.42 96.2 2 K.AVEHMFETEDGSKDEWR.GTax_Id=10090 Gene_Symbol=Rpl15 60S ribosomal protein L15 Tax_Id=10090 Gene_Symbol=Gm4294 similar to ribosomal protein L15 Tax_Id=10090 Gene_Symbol=Gm4581 similar to ribosomal protein L15 Tax_Id=10090 Gene_Symbol=- 24 kDa protein

Tax_Id=10090 Gene_Symbol=LOC634785 similar to ribosomal protein L15 Tax_Id=10090 Gene_Symbol=Gm10020 similar to ribosomal protein L15 isoform 1 Tax_Id=10090 Gene_Symbol=Gm8420 similar to ribosomal protein L15 Tax_Id=10090 Gene_Symbol=Gm5292 similar to ribosomal protein L15

1 8.491267 4.46 86.4 1 R.VLNSYWVGEDSTYK.FTax_Id=10090 Gene_Symbol=Rpl18 60S ribosomal protein L18

1 7.081656 4.46 95.2 1 K.TAVVVGTVTDDVR.ITax_Id=10090 Gene_Symbol=Usp15 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 15

1 5.931719 4.25 66.7 1 K.EHLIDELDYILLPTEGWNK.L1 6.039727 10.04 60.7 1 R.GPSTPKS(79.9663)PGASNFSTLPK.I2 6.825223 4.25 44.4 2 R.FAPQFSGYQQQDCQELLAFLLDGLHEDLNR.I

Tax_Id=10090 Gene_Symbol=Canx Calnexin 1 8.913884 3.87 55.7 1 A.HDGHDDDAIDIEDDLDDVIEEVEDSK.S1 5.745703 4.57 70.8 1 K.YDGKWEVDEMKETK.L

Tax_Id=10090 Gene_Symbol=Eif3d Eukaryotic translation initiation factor 3 subunit D 1 5.586989 4.25 75 2 R.SDWEVKEEMDFPQLMK.M1 9.051258 3.8 79.3 1 R.YLEVSEPQDIECCGALEYYDK.A1 4.671405 3.8 48.2 1 R.YLEVSEPQDIECCGALEYYDK.A

Tax_Id=10090 Gene_Symbol=- 55 kDa protein 1 6.431736 4.01 36.6 2 R.MLPHAPGVQMQAIPEDAIPEES(79.9663)GDEDEEDPDKR.I

Tax_Id=10090 Gene_Symbol=Ankfy1 Isoform 2 of Ankyrin repeat and FYVE domain-containing protein 1 1 5.593844 4.4 40 1 K.KYSADVMSEMAQIAEALLQAGANPNMQDSK.G

Tax_Id=10090 Gene_Symbol=Ppp2cb Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Tax_Id=10090 Gene_Symbol=Ppp2ca Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1 5.119167 4.12 63.8 2 R.LQEVPHEGPMCDLLWSDPDDR.GTax_Id=10090 Gene_Symbol=Rpl6 60S ribosomal protein L6 Tax_Id=10090 Gene_Symbol=Gm6136 similar to ribosomal protein L6 Tax_Id=10090 Gene_Symbol=Gm5428 similar to ribosomal protein L6

1 7.182919 4.4 100 14 R.HQEGEIFDTEK.E1 7.457183 4.58 70.3 4 R.HQEGEIFDTEKEK.Y1 8.824912 4.53 88.9 4 R.HQEGEIFDTEKEKYEITEQR.K1 8.858498 4.53 54.2 2 R.HQEGEIFDTEKEKYEITEQR.K

44 5.518724 4.53 40.2 1 R.HQEGEIFDTEKEKYEITEQR.KTax_Id=10090 Gene_Symbol=Dnajb9 DnaJ homolog subfamily B member 9 Tax_Id=10090 Gene_Symbol=Dnajb9 Dnajb9 protein

1 10.6403 3.96 100 1 R.EIAEAYETLSDANSR.KTax_Id=10090 Gene_Symbol=Grhpr Glyoxylate reductase/hydroxypyruvate reductase Tax_Id=10090 Gene_Symbol=Grhpr 21 kDa protein

1 6.686914 3.86 88.9 2 R.AALAQAADCEVEQWNSDDPIPR.K1 7.126633 3.86 52.4 3 R.AALAQAADCEVEQWNSDDPIPR.K

Tax_Id=10090 Gene_Symbol=Gm5611 similar to Nucleophosmin 1 isoform 1 1 6.739462 4.25 93.5 1 K.DELHIVEAEAMNYEGSPIK.V

Tax_Id=10090 Gene_Symbol=Scyl2 Isoform 1 of SCY1-like protein 2 12 6.584411 4.14 42.9 1 K.IPFFDDVGAVTLQYFDTLFQR.D

1 8.210492 4.14 95.8 1 R.SLDIGNQMSTSEETK.V1 8.346383 4.25 63.3 1 K.VFNNIGADLLSGSESENREDGMQGK.Q

Tax_Id=10090 Gene_Symbol=Hsph1 Isoform HSP105-beta of Heat shock protein 105 kDa 1 7.963583 4.14 95 2 R.AGGIETIANEFSDR.C

1 5.823019 4.4 57.4 1 R.RGPFELEAFYSDPQGVPYPEAK.I1 9.918936 3.69 85.7 1 R.LLTETEDWLYEEGEDQAK.Q

no description1 6.356577 3.96 95 1 R.ALEEANADLEVK.I1 7.43499 3.86 84.6 1 K.TDLEMQIESLNEELAYMK.K

Tax_Id=10090 Gene_Symbol=Pwp1 Putative uncharacterized protein 1 5.902045 4.42 64.9 2 K.DTEQYEHEDFLIKPTDNLIVCGR.A

Tax_Id=10090 Gene_Symbol=Nedd4 Neural cell expressed, developmentally down-regulted gene 4, isoform CRA_c 1 7.830691 3.96 75.9 2 R.DDFLGQVDVPLYPLPTENPR.M

Tax_Id=10090 Gene_Symbol=Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 1 9.482121 4.25 89.7 1 K.GDVAEGDLIEHFSQFGAVEK.A

Tax_Id=10090 Gene_Symbol=Sf3b1 Putative uncharacterized protein 1 6.778873 3.96 58.6 2 K.DYIYAVTPLLEDALMDR.D

Tax_Id=10090 Gene_Symbol=Plin2 Adipose differentiation related protein 1 6.26367 4.46 100 1 K.DSVASTVSGVVDK.T

Tax_Id=10090 Gene_Symbol=Ppia Peptidyl-prolyl cis-trans isomerase 1 5.805728 4.14 88.2 1 K.EGMNIVEAMER.F

Tax_Id=10090 Gene_Symbol=Gm6301 hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Rpl27 60S ribosomal protein L27

1 8.942692 4.46 86.7 1 R.YSVDIPLDK.TTax_Id=10090 Gene_Symbol=Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform

1 7.141724 3.8 78.6 1 R.ELEQQMQQILDDTSEPQPGEAK.L1 5.420929 3.8 62.1 1 R.ELEQQMQQILDDTSEPQPGEAK.L1 8.9568 3.95 66.7 2 K.AAFFVTLDESEQGYREEDPEASIDSYAK.S2 5.384557 3.95 46.5 1 K.AAFFVTLDESEQGYREEDPEASIDSYAK.S

Tax_Id=10090 Gene_Symbol=Tceb3 Transcription elongation factor B polypeptide 3 Tax_Id=10090 Gene_Symbol=Tceb3 Transcription elongation factor B (SIII), polypeptide 3

1 7.759032 4.42 44.4 2 R.DALQREEELEGNYQESWKPSGSR.S3 7.164564 3.89 41.2 1 K.AEETDVDDEFERPTMSFESYLSYDQPR.K

Tax_Id=10090 Gene_Symbol=Akr1c19 aldo-keto reductase family 1, member C19 2 5.47708 4.03 43.9 1 K.ENEIKENIQVFEFELPSEDMK.I1 7.872746 3.86 84.6 1 K.ENIQVFEFELPSEDMK.I

Tax_Id=10090 Gene_Symbol=Mrpl45 39S ribosomal protein L45, mitochondrial Tax_Id=10090 Gene_Symbol=Mrpl45 Putative uncharacterized protein (Fragment)

1 8.09072 4.25 48.1 1 R.LMYGQEDVPKDVLEYVVFER.HTax_Id=10090 Gene_Symbol=Srpk2 WW domain binding protein 6 (Fragment) Tax_Id=10090 Gene_Symbol=Srpk2 serine/arginine-rich protein-specific kinase 2

1 5.678046 4.12 54.9 1 R.ESDPSDPNKDMVVQLIDDFK.ITax_Id=10090 Gene_Symbol=- 33 kDa protein Tax_Id=10090 Gene_Symbol=Gm9774 similar to Adhesion regulating molecule 1 isoform 1 Tax_Id=10090 Gene_Symbol=Gm9774 similar to Adhesion regulating molecule 1 isoform 2 Tax_Id=10090 Gene_Symbol=Adrm1 Proteasomal ubiquitin receptor ADRM1 Tax_Id=10090 Gene_Symbol=Adrm1 Adrm1 protein

1 7.373424 4.12 59.3 1 R.TSGTVEDDLIIFPDDCEFKR.VTax_Id=10090 Gene_Symbol=Rps4x 40S ribosomal protein S4, X isoform Tax_Id=10090 Gene_Symbol=Gm9294 predicted gene 9294

1 8.590503 4.14 78.6 1 R.TDITYPAGFMDVISIDK.TTax_Id=10090 Gene_Symbol=Ppib Peptidyl-prolyl cis-trans isomerase B

1 6.31517 6.56 87 1 R.DKPLKDVIIVDSGK.I1 6.08031 6.56 75.7 1 R.DKPLKDVIIVDSGK.I

Tax_Id=10090 Gene_Symbol=Uox 23 kDa protein 1 6.769864 4.72 90.9 2 R.RDVDFEAIWGAVR.D1 6.152906 4.14 100 1 R.DVDFEAIWGAVR.D

Tax_Id=10090 Gene_Symbol=Cars Isoform 1 of Cysteinyl-tRNA synthetase, cytoplasmic Tax_Id=10090 Gene_Symbol=Cars Isoform 2 of Cysteinyl-tRNA synthetase, cytoplasmic

1 4.788624 4.03 42.5 1 K.VQVLLEEAKDLLSDWLDSTGGSEVTDNSIFSK.L1 5.114928 4.12 52.7 1 R.APVDITGQFEKWEAEEVELNK.N1 5.019541 3.96 88.2 1 K.WEAEEVELNK.N

Tax_Id=10090 Gene_Symbol=Dnajb11 DnaJ homolog subfamily B member 11 1 8.173158 4.03 67.7 1 R.DGMEYPFIGEGEPHVDGEPGDLR.F1 5.289865 4.03 44.1 1 R.DGMEYPFIGEGEPHVDGEPGDLR.F

Tax_Id=10090 Gene_Symbol=Sfxn5 Sideroflexin-5 Tax_Id=10090 Gene_Symbol=Sfxn5 Putative uncharacterized protein

1 9.911429 3.8 93.3 1 R.YGELEEGIDVLDADGNLVGSSK.ITax_Id=10090 Gene_Symbol=Ttc35 Tetratricopeptide repeat protein 35

2 6.689462 3.86 51.9 1 R.NSEQIMEVGEELINDYASK.LTax_Id=10090 Gene_Symbol=Rrp7a Ribosomal RNA-processing protein 7 homolog A Tax_Id=10090 Gene_Symbol=Gm3436 hypothetical protein

1 5.926594 4.25 76.7 1 K.TVELQEKPDLAESPTEPK.STax_Id=10090 Gene_Symbol=Mtap S-methyl-5'-thioadenosine phosphorylase

1 9.707487 3.96 76.7 1 K.IGIIGGTGLDDPEILEGR.TTax_Id=10090 Gene_Symbol=Srrm2 Srrm2 protein

1 7.986946 3.64 92.3 1 R.CLELEEMMEEQGYEEQQIQEK.V1 7.638578 3.64 51.7 1 R.CLELEEMMEEQGYEEQQIQEK.V1 7.805557 4.58 75.9 1 K.EETPGQRPVVTETHQLAELNEK.K

27 4.904378 4.58 37.7 1 K.EETPGQRPVVTETHQLAELNEK.K1 7.760741 6.56 53.1 1 K.S(79.9663)GTPPRPGSVTNMQADECTATPQR.Q1 8.303785 6.56 55.4 1 K.SGT(79.9663)PPRPGSVTNMQADECTATPQR.Q1 6.975522 6.56 48.4 1 K.S(79.9663)GTPPRPGSVTNMQADECTAT(79.9663)PQR.Q1 6.36395 6.56 57.7 1 R.DKFS(79.9663)PTQDRPESSTVLK.V1 5.777978 3.96 61.5 2 K.SLLPNSSQDELMEVEK.S1 7.363914 5.63 65.5 1 K.AAETPAVASCWSGPQVS(79.9663)PEHK.E2 9.438515 3.86 45.2 1 K.EELNGSFLNQTEADPSVDMK.E1 4.987989 12 69.2 3 R.NHSGS(79.9663)RTPPVALSSSR.M1 5.137278 8.26 62.5 1 R.CRS(79.9663)PGMLEPLGSAR.T

Tax_Id=10090 Gene_Symbol=Bclaf1 Isoform 2 of Bcl-2-associated transcription factor 1 Tax_Id=10090 Gene_Symbol=Bclaf1 Isoform 3 of Bcl-2-associated transcription factor 1 Tax_Id=10090 Gene_Symbol=Bclaf1 Isoform 1 of Bcl-2-associated transcription factor 1

1 6.238249 4.2 71.4 1 K.SQEEPKDTFEHDPSESIDEFNK.S1 6.427136 4.2 50 1 K.SQEEPKDTFEHDPSESIDEFNK.S3 5.305352 4.19 46.4 1 K.GRADGDWDDQEVLDYFS(79.9663)DKESAK.Q1 8.205886 3.95 72 1 R.ADGDWDDQEVLDYFS(79.9663)DKESAK.Q1 6.645221 3.95 56.9 1 R.ADGDWDDQEVLDYFS(79.9663)DKESAK.Q1 6.213866 7.25 86.4 2 K.LKELFDYS(79.9663)PPLHK.S1 4.929446 7.25 57.5 1 K.LKELFDYS(79.9663)PPLHK.S

Tax_Id=10090 Gene_Symbol=Rbm10 Isoform 1 of RNA-binding protein 10

Tax_Id=10090 Gene_Symbol=Rbm10 103 kDa protein Tax_Id=10090 Gene_Symbol=Rbm10 Isoform 3 of RNA-binding protein 10

1 5.780915 12 72.2 3 R.HRHS(79.9663)PTGPPGFPR.D2 6.01637 3.67 42.6 1 R.TEQGEEEEEEDEEEEEEKASNIVMLR.M1 4.960102 4.42 85.7 1 R.AHLSENELEALEKNDMEQMK.Y

Tax_Id=10090 Gene_Symbol=Copg Putative uncharacterized protein 7 5.386787 4.03 40 1 K.QLEEEDGSRDSPLFDFIESCLR.N1 7.096972 3.71 45 2 K.DCDPNTGEIDEEGYEDEYVLEDLEVTVADHIQK.V

Tax_Id=10090 Gene_Symbol=Por NADPH--cytochrome P450 reductase Tax_Id=10090 Gene_Symbol=Por Por protein

1 12.95715 3.69 96.9 1 R.IFELGLGDDDGNLEEDFITWR.E1 6.154703 3.69 59.6 1 R.IFELGLGDDDGNLEEDFITWR.E4 7.016111 4.84 44.1 2 R.TNVLYELAQYASEPSEQEHLHK.M

Tax_Id=10090 Gene_Symbol=Srpk1 Serine/threonine-protein kinase SRPK1 1 6.965266 3.96 70.4 1 K.LEESNSIGQDQTLTER.G

15 5.882138 3.8 36.8 1 K.YEWPQEEAAGFTDFLLPMLELMPEK.RTax_Id=10090 Gene_Symbol=Flna Protein

1 4.659928 4.72 93.8 1 K.DLAEDAPWKK.I1 8.420554 4.25 74.2 1 R.SAGQGEVLVYVEDPAGHQEEAK.V

Tax_Id=10090 Gene_Symbol=Krt16 Keratin intermediate filament 16a Tax_Id=10090 Gene_Symbol=Krt16 Keratin, type I cytoskeletal 16

1 5.56328 6.56 100 2 K.VTMQNLNDR.L1 8.221689 3.96 52.9 1 R.GQTGGDVNVEMDAAPGVDLSR.I

Tax_Id=10090 Gene_Symbol=Dnaja1 DnaJ homolog subfamily A member 1 Tax_Id=10090 Gene_Symbol=Gm15542 similar to DnaJ-like protein Tax_Id=10090 Gene_Symbol=Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 Tax_Id=10090 Gene_Symbol=Gm7816 similar to DnaJ-like protein

1 8.241656 4.12 83.3 4 K.ITFHGEGDQEPGLEPGDIIIVLDQK.D1 5.152883 4.12 57.4 4 K.ITFHGEGDQEPGLEPGDIIIVLDQK.D

Tax_Id=10090 Gene_Symbol=Sqstm1 42 kDa protein 1 7.227599 3.96 69.7 2 R.FSFCFSPEPEAEAQAAAGPGPCER.L

Tax_Id=10090 Gene_Symbol=Csnk2a2 Casein kinase II subunit alpha' 2 6.842186 4.25 45 1 R.EYWDYEAHVPSWGNQDDYQLVR.K

Tax_Id=10090 Gene_Symbol=Twf1 Twinfilin-1 Tax_Id=10090 Gene_Symbol=Gm4887 similar to Twinfilin, actin-binding protein, homolog 1

1 7.664631 4.28 63.8 2 R.KIEIDNGDELTADFLYDEVHPK.QTax_Id=10090 Gene_Symbol=LOC100047957 similar to Casein kinase 2, alpha 1 polypeptide

3 6.536666 4.12 52 1 K.VLGTEDLYDYIDKYNIELDPR.FTax_Id=10090 Gene_Symbol=Hsd17b7 3-keto-steroid reductase

1 5.491309 3.95 59.3 1 K.MDIDEDTAEKFYEVLLELEK.R1 7.149722 4.19 56.9 1 K.MDIDEDTAEKFYEVLLELEKR.V

Tax_Id=10090 Gene_Symbol=Dhdh Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase 1 10.28256 3.8 90 1 K.ESPVVPLAESELLAEILEEAR.K

Tax_Id=10090 Gene_Symbol=Gm3200 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=- 36 kDa protein Tax_Id=10090 Gene_Symbol=- 36 kDa protein Tax_Id=10090 Gene_Symbol=Gm10284 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100047232 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1

Tax_Id=10090 Gene_Symbol=Gm13464 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=Gm3534 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=Gm2606 similar to Glyceraldehyde-3-phosphate dehydrogenase isoform 1 Tax_Id=10090 Gene_Symbol=Gm13292 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm10358 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 Tax_Id=10090 Gene_Symbol=Gm2451 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100048117 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=- similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 Tax_Id=10090 Gene_Symbol=LOC100047129 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=LOC100047232 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 Tax_Id=10090 Gene_Symbol=Gm2606 similar to Glyceraldehyde-3-phosphate dehydrogenase isoform 3 Tax_Id=10090 Gene_Symbol=Gm3222 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=Gm10358 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm10284 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 Tax_Id=10090 Gene_Symbol=LOC100046806;Gm10327 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm10293;Gapdh similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=- similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm4609 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100044724 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=LOC100045908 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm2451 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 Tax_Id=10090 Gene_Symbol=Gm10291 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=- similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm3839 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100042025 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 Tax_Id=10090 Gene_Symbol=Gm5507 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=LOC100044981 similar to Glyceraldehyde-3-phosphate dehydrogenase Tax_Id=10090 Gene_Symbol=Gm10293;Gapdh;LOC100042025;Gm10359;Gm2574;Gm5138;Gm12033;Gm3272 Glyceraldehyde-3-phosphate dehydrogenase

1 9.423004 3.96 90 3 K.WGEAGAEYVVESTGVFTTMEK.A1 5.568315 3.96 50.8 1 K.WGEAGAEYVVESTGVFTTMEK.A

Tax_Id=10090 Gene_Symbol=Mrpl47 39S ribosomal protein L47, mitochondrial 1 7.928679 4.12 83.3 2 K.GLEEFFDDPKNWGEEK.V

Tax_Id=10090 Gene_Symbol=Sfrs9 Splicing factor, arginine/serine-rich 9 10 5.954618 4.25 55 1 R.FEDPRDAEDAIYGR.N

Tax_Id=10090 Gene_Symbol=Gm5766 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=- 30 kDa protein

1 7.380002 6.56 85.7 1 R.AGVNTVTTLVENK.KTax_Id=10090 Gene_Symbol=Rars Arginyl-tRNA synthetase, cytoplasmic

4 8.800476 4.4 37.5 3 K.DFVSEQLTSLLVNGVQLPVLGDKEK.V1 9.410092 4.14 92.3 2 K.SDGGYTYDTSDLAAIK.Q

Tax_Id=10090 Gene_Symbol=Oasl1 Putative uncharacterized protein 1 8.810019 4.25 88.5 2 R.EWKEEVLETVQTVEQFLR.Q1 5.432335 4.25 62.5 1 R.EWKEEVLETVQTVEQFLR.Q1 6.022257 4.4 64.3 1 R.LEFQGHILEDWFDFK.S

Tax_Id=10090 Gene_Symbol=Fmo5;LOC100046051 flavin containing monooxygenase 5 Tax_Id=10090 Gene_Symbol=LOC100046051 similar to Flavin containing monooxygenase 5 isoform 3

22 4.628413 4.42 31.7 1 R.HTIQGDYIDTMEEIADLVGVRPNILPLVFTDPR.LTax_Id=10090 Gene_Symbol=Cct2 T-complex protein 1 subunit beta

Tax_Id=10090 Gene_Symbol=Cct2 Brain cDNA, clone MNCb-1272, similar to Mus musculus chaperonin subunit 2 (beta) (Cct2), mRNA 1 10.47244 3.86 72.7 1 R.VQDDEVGDGTTSVTVLAAELLR.E1 6.380325 3.86 55.7 1 R.VQDDEVGDGTTSVTVLAAELLR.E1 5.866506 4.89 94.1 1 K.VAEIEHAEKEK.M

Tax_Id=10090 Gene_Symbol=Fus RNA-binding protein FUS Tax_Id=10090 Gene_Symbol=Fus 53 kDa protein

1 8.026333 4.03 42.5 2 R.HDSEQDNSDNNTIFVQGLGENVTIESVADYFK.QTax_Id=10090 Gene_Symbol=Phkg2 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform Tax_Id=10090 Gene_Symbol=Phkg2 phosphorylase kinase, gamma 2

1 8.734536 3.8 71.9 1 R.LFPIAATELEGDSGAITEDEATLVR.S1 4.970163 3.8 49.3 1 R.LFPIAATELEGDSGAITEDEATLVR.S

Tax_Id=10090 Gene_Symbol=Smn1 Survival motor neuron protein 1 8.257082 3.86 77.8 1 R.GTGQSDDSDIWDDTALIK.A

Tax_Id=10090 Gene_Symbol=Gstm1 23 kDa protein 1 7.568022 4.14 94.4 1 R.ADIVENQVMDTR.M

Tax_Id=10090 Gene_Symbol=Mrpl11 39S ribosomal protein L11, mitochondrial 1 7.873481 3.96 100 1 K.DLSAEELEAFQK.E

Tax_Id=10090 Gene_Symbol=Rpl26l1 similar to ribosomal protein L26 1 4.525352 6.56 100 1 K.FNPFVTSDR.S

Tax_Id=10090 Gene_Symbol=Farp1 FERMRhoGEF (Arhgef) and pleckstrin domain protein 1 Tax_Id=10090 Gene_Symbol=LOC100045542 similar to FERMRhoGEF (Arhgef) and pleckstrin domain protein 1

1 6.204536 4.46 90.5 1 R.LGAPENSGIST(79.9663)LER.G55 5.747303 4.12 31.6 2 R.LTCNDTSAALLISHIVQSEIGDFDEALDR.E

4 5.452498 4.53 33.1 1 R.LTCNDTSAALLISHIVQSEIGDFDEALDREHLAK.N1 6.01532 7.11 78.3 2 K.ACTLELGPHQS(79.9663)PALPK.S

Tax_Id=10090 Gene_Symbol=Dach1 Isoform 1 of Dachshund homolog 1 Tax_Id=10090 Gene_Symbol=Dach1 Dach1 protein Tax_Id=10090 Gene_Symbol=Dach1 Isoform 2 of Dachshund homolog 1

15 4.154581 6.12 27.4 1 M.AVPAALIPPT(79.9663)QLVPPQPPISTSASSSGT(79.9663)TTSTSSATSSPAPSIGPP.ATax_Id=10090 Gene_Symbol=Tubb2b Tubulin beta-2B chain Tax_Id=10090 Gene_Symbol=Tubb2a Tubulin beta-2A chain

1 8.410699 4.28 46.7 1 K.FWEVISDEHGIDPTGSYHGDSDLQLER.ITax_Id=10090 Gene_Symbol=Tubb5 Tubulin beta-5 chain

1 7.316475 4.28 48.6 3 K.FWEVISDEHGIDPTGTYHGDSDLQLDR.ITax_Id=10090 Gene_Symbol=Tubb4 Tubulin beta-4 chain Tax_Id=10090 Gene_Symbol=Tubb2c Tubulin beta-2C chain

1 6.901072 4.28 52 2 K.FWEVISDEHGIDPTGTYHGDSDLQLER.ITax_Id=10090 Gene_Symbol=BC003331 Isoform 2 of Protein odr-4 homolog Tax_Id=10090 Gene_Symbol=BC003331 50 kDa protein Tax_Id=10090 Gene_Symbol=BC003331 Isoform 3 of Protein odr-4 homolog Tax_Id=10090 Gene_Symbol=BC003331 Isoform 1 of Protein odr-4 homolog

1 6.087678 4.28 44.8 1 R.DILNTVADRCEILFEDLLLNEIPEKK.NTax_Id=10090 Gene_Symbol=Glyat Isoform 1 of Glycine N-acyltransferase Tax_Id=10090 Gene_Symbol=Glyat Isoform 2 of Glycine N-acyltransferase

1 9.555967 3.96 92.9 2 K.DPQNCQEFLESSEVINWK.QTax_Id=10090 Gene_Symbol=Iqgap2 Ras GTPase-activating-like protein IQGAP2

1 5.543529 4.14 63 1 R.NPNAVLTCVDDSLSQEYQK.E1 8.895764 3.86 85.7 1 K.VLWLDEIQQAINEANVDENR.A

1 6.006921 3.86 62.3 1 K.VLWLDEIQQAINEANVDENR.A1 8.552951 3.96 85.7 1 K.TDNESSEGSWVTLNVQEK.Y1 9.436985 3.64 80 1 K.ESWLTGEEIEDIVEEVTSDYIR.E1 7.323577 4.25 88.5 1 R.KYFQEACDVPEPEEK.F1 7.464371 3.86 79.2 1 K.YFQEACDVPEPEEK.F

Tax_Id=10090 Gene_Symbol=Slc27a5 Bile acyl-CoA synthetase 1 6.825992 3.86 83.3 2 R.SSGASVLIVDPDLQENLEEVLPK.L1 4.625417 3.86 56.1 2 R.SSGASVLIVDPDLQENLEEVLPK.L1 8.648916 3.96 88.9 1 R.EGFDVGIIADPLYILDNK.A

Tax_Id=10090 Gene_Symbol=Tubb6 Tubulin beta-6 chain 2 5.952949 4.12 38.2 1 K.FWEVISDEHGIDQAGGYVGDSALQLER.I

Tax_Id=10090 Gene_Symbol=Arg1 Arginase-1 1 5.462992 4.72 80 1 K.LKETEYDVR.D1 5.454742 4.72 94.1 1 R.DVDPGEHYIIK.T

Tax_Id=10090 Gene_Symbol=Rgn Regucalcin 1 8.014753 4.12 89.3 1 K.MEKDEQIPDGMCIDAEGK.L

Tax_Id=10090 Gene_Symbol=Zfr Protein 1 4.203909 4.25 67.9 1 R.EGDVTSGMVKDPPDVLDR.Q

Tax_Id=10090 Gene_Symbol=Psme1 Proteasome activator complex subunit 1 1 8.737762 4.25 87.5 1 R.QLVHELDEAEYQEIR.L1 4.908009 4.25 65 1 R.QLVHELDEAEYQEIR.L

Tax_Id=10090 Gene_Symbol=Dlst Isoform 2 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 1 8.089745 4.14 95 1 R.NVETMNYADIER.T

Tax_Id=10090 Gene_Symbol=Foxo4 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Foxo3 26 kDa protein

1 6.083241 6.56 94.1 4 K.DKGDSNSSAGWK.V1 6.413917 6.56 100 7 K.DKGDSNSSAGWK.V

Tax_Id=10090 Gene_Symbol=Myo18a Isoform 2 of Myosin-XVIIIa Tax_Id=10090 Gene_Symbol=Myo18a Isoform 5 of Myosin-XVIIIa Tax_Id=10090 Gene_Symbol=Myo18a Isoform 7 of Myosin-XVIIIa Tax_Id=10090 Gene_Symbol=Myo18a Isoform 6 of Myosin-XVIIIa Tax_Id=10090 Gene_Symbol=Myo18a Isoform 1 of Myosin-XVIIIa Tax_Id=10090 Gene_Symbol=Myo18a Isoform 3 of Myosin-XVIIIa

1 5.426135 3.86 100 1 R.AVEELLESLDLEK.S1 6.860967 3.95 43.6 1 R.ISELTSELTDERNTGESASQLLDAETAER.L1 7.883195 3.96 88.9 2 R.NTGESASQLLDAETAER.L1 6.858555 4.12 50 1 K.VVSLEAELQDISSQESKDEASLAK.V1 5.133248 4.03 63 1 K.VKDQEEELDEQAGSIQMLEQAK.L1 5.900329 3.8 95 1 R.LEEDQEDMNELMK.K

Tax_Id=10090 Gene_Symbol=Eif5b Eukaryotic translation initiation factor 5B 1 10.67839 4.03 87.5 3 K.SEDSTKDDTDLGALAAEIEGAGAAK.E1 4.953262 4.03 55.6 1 K.SEDSTKDDTDLGALAAEIEGAGAAK.E1 7.480914 3.86 71.4 2 K.SVPTVDSGNEDDDSSFK.I1 6.96282 4.4 46.7 2 R.GSSLCDIAILVVDIMHGLEPQTIESINILK.S

Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 1 of Heterogeneous nuclear ribonucleoprotein U-like protein 1 Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 2 of Heterogeneous nuclear ribonucleoprotein U-like protein 1

16 4.255572 4.23 30.3 1 R.RGRS(79.9663)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK.V5 5.188077 4.71 52.8 1 K.RTDEEGKDVPDHAVLEMK.A

1 5.718867 4.42 66 1 R.TDEEGKDVPDHAVLEMK.ATax_Id=10090 Gene_Symbol=Hsp90aa1 Heat shock protein HSP 90-alpha

1 8.340808 3.86 87.5 1 R.NPDDITNEEYGEFYK.S1 4.641105 4.57 50 1 K.CLELFTELAEDKENYKK.F1 6.76872 4.46 84.2 1 K.DQVANSAFVER.L

Tax_Id=10090 Gene_Symbol=Cttn Src substrate cortactin Tax_Id=10090 Gene_Symbol=Cttn Cortactin, isoform CRA_e Tax_Id=10090 Gene_Symbol=Cttn Putative uncharacterized protein

1 7.691321 3.89 44.3 1 K.ASAGHAVSITQDDGGADDWETDPDFVNDVSEK.ETax_Id=10090 Gene_Symbol=Dnpep aspartyl aminopeptidase isoform a Tax_Id=10090 Gene_Symbol=Dnpep aspartyl aminopeptidase isoform b

1 5.240652 4.25 41.3 2 R.NINENFGPNTEIHLVPILATAVQEELEK.GTax_Id=10090 Gene_Symbol=Wdr4 WD repeat domain 4

1 5.447393 4.12 47.1 1 K.ATPEDKGEDGQPADTGSDSILASTFSK.STax_Id=10090 Gene_Symbol=Psmd13 Isoform 1 of 26S proteasome non-ATPase regulatory subunit 13 Tax_Id=10090 Gene_Symbol=Psmd13 Isoform 2 of 26S proteasome non-ATPase regulatory subunit 13

1 6.331887 4.25 73.3 1 K.ETIEDVEEMLNNLPGVTSVHSR.F1 6.549773 4.25 62.9 1 K.ETIEDVEEMLNNLPGVTSVHSR.F

Tax_Id=10090 Gene_Symbol=Lman2 Lectin, mannose-binding 2 Tax_Id=10090 Gene_Symbol=Lman2 Vesicular integral-membrane protein VIP36

1 4.903993 4.25 57.4 1 K.DNFHGLAIFLDTYPNDETTER.VTax_Id=10090 Gene_Symbol=Ctsb Cathepsin B

1 8.322476 4.14 80 1 R.DQGSCGSCWAFGAVEAISDR.TTax_Id=10090 Gene_Symbol=Fhl3 Four and a half LIM domains protein 3 Tax_Id=10090 Gene_Symbol=Fhl3 four and a half LIM domains 3 Tax_Id=10090 Gene_Symbol=Fhl3 Four and a half LIM domains 3

1 7.564815 3.96 82.1 2 R.DDDPYCVACFGELFAPK.CTax_Id=10090 Gene_Symbol=Psme2 Proteasome activator complex subunit 2 Tax_Id=10090 Gene_Symbol=Psme2 proteasome activator subunit 2 isoform 2

2 4.813158 3.96 62.5 1 K.IEDGNDFGVAIQEK.VTax_Id=10090 Gene_Symbol=Srrm2 Isoform 3 of Serine/arginine repetitive matrix protein 2 Tax_Id=10090 Gene_Symbol=Srrm2 Isoform 1 of Serine/arginine repetitive matrix protein 2

1 7.986946 3.64 92.3 1 R.CLELEEMMEEQGYEEQQIQEK.V1 7.638578 3.64 51.7 1 R.CLELEEMMEEQGYEEQQIQEK.V1 7.805557 4.58 75.9 1 K.EETPGQRPVVTETHQLAELNEK.K

27 4.904378 4.58 37.7 1 K.EETPGQRPVVTETHQLAELNEK.K1 7.760741 6.56 53.1 1 K.S(79.9663)GTPPRPGSVTNMQADECTATPQR.Q1 8.303785 6.56 55.4 1 K.SGT(79.9663)PPRPGSVTNMQADECTATPQR.Q1 6.975522 6.56 48.4 1 K.S(79.9663)GTPPRPGSVTNMQADECTAT(79.9663)PQR.Q1 6.36395 6.56 57.7 1 R.DKFS(79.9663)PTQDRPESSTVLK.V1 5.777978 3.96 61.5 2 K.SLLPNSSQDELMEVEK.S2 9.438515 3.86 45.2 1 K.EELNGSFLNQTEADPSVDMK.E1 4.987989 12 69.2 3 R.NHSGS(79.9663)RTPPVALSSSR.M1 5.137278 8.26 62.5 1 R.CRS(79.9663)PGMLEPLGSAR.T

Tax_Id=10090 Gene_Symbol=Hnrnpm Isoform 1 of Heterogeneous nuclear ribonucleoprotein M Tax_Id=10090 Gene_Symbol=Hnrnpm Isoform 2 of Heterogeneous nuclear ribonucleoprotein M

2 4.799319 4.25 60.9 1 K.EKVGEVTYVELLMDAEGK.S1 8.648477 3.96 92 1 K.VGEVTYVELLMDAEGK.S

15 5.155983 5.8 53.5 1 K.DKFNECGHVLYADIK.M1 5.680079 4.14 100 3 K.FESPEVAER.A

Tax_Id=10090 Gene_Symbol=Sgpl1 Sphingosine-1-phosphate lyase 1 Tax_Id=10090 Gene_Symbol=Sgpl1 55 kDa protein

1 5.048518 4.4 72.7 2 K.LKDFEPYLEILESYSTK.A1 5.783876 4.72 73.1 1 K.TPEIVAPESAHAAFDK.A

Tax_Id=10090 Gene_Symbol=Es31 Isoform 1 of Liver carboxylesterase 31 Tax_Id=10090 Gene_Symbol=Es31 Isoform 2 of Liver carboxylesterase 31

54 5.569647 3.95 30.1 1 K.ADHSSENAFVFGGPFLTDESSLLAFPEATEEEK.QTax_Id=10090 Gene_Symbol=Capn2 Putative uncharacterized protein

6 6.551599 3.9 35.1 2 K.KADYQAVDDEIEANIEEIDANEEDIDDGFRR.LTax_Id=10090 Gene_Symbol=Rsl1d1 Putative uncharacterized protein

61 3.661933 4.28 33.8 1 K.QKVTEECEEAIPQLVPIGETPDKENVK.M1 5.012496 4.03 49.3 2 K.VTEECEEAIPQLVPIGETPDKENVK.M

Tax_Id=10090 Gene_Symbol=Krt17 Keratin, type I cytoskeletal 17 1 7.161708 3.96 94.7 1 R.ALEEANTELEVK.I1 8.357609 4.72 86.4 1 R.DYSAYYHTIEDLK.N

Tax_Id=10090 Gene_Symbol=Echs1 Protein 1 6.291497 4.14 100 1 K.LVEEAIQCAEK.I

Tax_Id=10090 Gene_Symbol=Upf1 Isoform 1 of Regulator of nonsense transcripts 1 Tax_Id=10090 Gene_Symbol=Upf1 Isoform 2 of Regulator of nonsense transcripts 1

1 8.380729 3.69 71.4 1 K.TSQLLAELNFEEDEEDTYYTK.D1 7.976356 4.28 45.6 2 K.ENPSATLEDLEKPGVDEEPQHVLLR.Y1 7.273041 4.25 96.4 1 K.LQQLKDETGELSSADEK.R1 5.252097 4.25 68.2 1 K.LQQLKDETGELSSADEK.R1 4.901688 4.57 57.3 1 K.LQQLKDETGELSSADEKR.Y

Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 4 of Dynamin-1-like protein 2 4.115016 4.03 51.9 1 M.LYTDFDEIRQEIENETER.I1 8.265374 3.86 89.3 1 K.SSLLDDLLTESEDMAQR.R

Tax_Id=10090 Gene_Symbol=Eefsec Selenocysteine-specific elongation factor Tax_Id=10090 Gene_Symbol=Eefsec eukaryotic elongation factor, selenocysteine-tRNA-specific

1 6.385222 4.25 37.2 2 R.GAPIIPVAAKPGGPEAPETEAPQGISELIELLK.STax_Id=10090 Gene_Symbol=Suox Sulfite oxidase, mitochondrial

20 5.338942 4.28 32.6 1 K.IGELNPEDSMSPSVEASDPYADDPIRHPALR.ITax_Id=10090 Gene_Symbol=Scp2 Isoform SCPx of Non-specific lipid-transfer protein

1 10.21548 3.86 86.7 1 K.AVEIVAQEMMTDLPSTFEEK.S1 6.112725 4.4 94.4 1 K.KLEEEGEQFVK.K

Tax_Id=10090 Gene_Symbol=Ecsit Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial 26 4.106043 3.89 38.7 1 R.ADLPPPEEEKVEEIPEEWELYYPQK.L

Tax_Id=10090 Gene_Symbol=Mrps31 28S ribosomal protein S31, mitochondrial 1 9.356914 3.8 75.9 2 K.AFADEPPEPEASPSLWEIEFAK.Q

Tax_Id=10090 Gene_Symbol=H2afy Isoform 1 of Core histone macro-H2A.1 Tax_Id=10090 Gene_Symbol=H2afy H2A histone family, member Y isoform 2 Tax_Id=10090 Gene_Symbol=H2afy H2A histone family, member Y isoform 4 Tax_Id=10090 Gene_Symbol=H2afy Isoform 2 of Core histone macro-H2A.1

1 7.462015 4.89 53.6 2 K.FVIHCNSPVWGADKCEELLEK.TTax_Id=10090 Gene_Symbol=Copb1 Coatomer subunit beta

1 8.055857 4.58 62.1 1 R.NFEHLIPDAPELIHDFLVNEK.D

1 6.947381 4.89 69.6 1 K.TNNVSEHEDTDKYR.Q1 6.854729 4.25 79.3 1 K.EAGELKPEEEITVGPVQK.L

Tax_Id=10090 Gene_Symbol=Pdia4 protein disulfide isomerase A4 1 10.53991 4.12 86.7 1 K.DLGLSESGEDVNAAILDESGKK.F1 5.772998 3.86 85.7 1 K.FAMEPEEFDSDTLR.E

Tax_Id=10090 Gene_Symbol=Xrcc6 ATP-dependent DNA helicase 2 subunit 1 1 11.13632 4.03 96.6 1 R.DIITTAEDEDLGVHFEESSK.L1 6.710979 4.57 78.3 2 R.QIVLEKEETEELKR.F

Tax_Id=10090 Gene_Symbol=Araf Serine/threonine-protein kinase A-Raf Tax_Id=10090 Gene_Symbol=Araf Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Araf v-raf murine sarcoma 3611 viral oncogene homolog isoform 2 Tax_Id=10090 Gene_Symbol=Araf V-raf murine sarcoma 3611 viral oncogene homolog

34 4.461355 4.03 31 1 K.TVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVR.KTax_Id=10090 Gene_Symbol=Iqcd Isoform 2 of IQ domain-containing protein D Tax_Id=10090 Gene_Symbol=Iqcd Isoform 1 of IQ domain-containing protein D

6 4.539896 7.33 37.5 1 R.ERHAVLVEEFS(79.9663)QIRAES(79.9663)EINSKKR.VTax_Id=10090 Gene_Symbol=Rg9mtd1 Mitochondrial ribonuclease P protein 1

2 5.539147 4.03 46.8 2 K.SSIQEDGVSEVSDKDEDSLASTR.ETax_Id=10090 Gene_Symbol=Fam98b Protein FAM98B

1 10.07535 3.8 90.6 2 R.GPELGPETSMEGDVLDTLEALGYK.GTax_Id=10090 Gene_Symbol=Cbwd1 Isoform 1 of COBW domain-containing protein 1 Tax_Id=10090 Gene_Symbol=Cbwd1 Isoform 2 of COBW domain-containing protein 1

1 5.950206 4.25 47.5 1 R.NLDKDVLQQLFLTAVAEAEEQR.TTax_Id=10090 Gene_Symbol=Atxn3 Ataxin-3 Tax_Id=10090 Gene_Symbol=Atxn3 33 kDa protein Tax_Id=10090 Gene_Symbol=Atxn3 Atxn3 protein Tax_Id=10090 Gene_Symbol=Atxn3 ataxin 3 isoform 2

1 9.788751 3.64 80 2 R.VLEAADGSGIFDEDEDDLQR.ATax_Id=10090 Gene_Symbol=Fbp1 Fructose-1,6-bisphosphatase 1 Tax_Id=10090 Gene_Symbol=Fbp1 Fructose-1,6-bisphosphatase

1 11.34548 3.96 90 2 K.APVVMGSSEDVQEFLEIYR.KTax_Id=10090 Gene_Symbol=Capza2 F-actin-capping protein subunit alpha-2

1 5.890068 4.14 80 1 K.DIQDSLTVSNEVQTAK.ETax_Id=10090 Gene_Symbol=Sar1b GTP-binding protein SAR1b

1 5.108244 4.4 77.8 3 K.IDRPEAISEER.LTax_Id=10090 Gene_Symbol=Gpx4 Isoform Mitochondrial of Phospholipid hydroperoxide glutathione peroxidase, mitochondrial Tax_Id=10090 Gene_Symbol=Gpx4 glutathione peroxidase 4 isoform 1 precursor Tax_Id=10090 Gene_Symbol=Gpx4 Phospholipid hydroperoxide glutathione peroxidase, nuclear

1 6.366694 4.72 94.4 1 K.DIDGHMVCLDK.YTax_Id=10090 Gene_Symbol=Gm7589 hypothetical protein Tax_Id=10090 Gene_Symbol=LOC100045024 similar to ribosomal protein L11 Tax_Id=10090 Gene_Symbol=Rpl11 Ribosomal protein L11 Tax_Id=10090 Gene_Symbol=Gm10288 similar to ribosomal protein L11 Tax_Id=10090 Gene_Symbol=Gm10036 similar to ribosomal protein L11 Tax_Id=10090 Gene_Symbol=Gm5093 similar to ribosomal protein L11 Tax_Id=10090 Gene_Symbol=Rpl11 60S ribosomal protein L11

1 4.491448 4.72 93.3 3 R.GAKAEEILEK.GTax_Id=10090 Gene_Symbol=Slc25a13 Calcium-binding mitochondrial carrier protein Aralar2

1 7.48371 4.4 91.7 1 K.DVEVTKEEFALAAQK.F1 5.479271 4.4 73.7 1 K.DVEVTKEEFALAAQK.F1 7.832393 3.96 85.7 1 K.FGQVTPMEVDILFQLADLYEPR.G

Tax_Id=10090 Gene_Symbol=Hspa1b Heat shock 70 kDa protein 1B Tax_Id=10090 Gene_Symbol=Hspa1a Inducible heat shock protein 70

1 5.409415 4.46 94.7 4 K.VEIIANDQGNR.T1 9.594308 4.14 75 2 K.QTQTFTTYSDNQPGVLIQVYEGER.A

Tax_Id=10090 Gene_Symbol=Nars Asparaginyl-tRNA synthetase, cytoplasmic Tax_Id=10090 Gene_Symbol=Nars asparaginyl-tRNA synthetase isoform 2

1 7.921456 3.69 72.4 1 K.EDGTFYEFGDDIPEAPER.L1 6.83885 4.4 100 1 R.SWDSEEILEGYKR.E

Tax_Id=10090 Gene_Symbol=Api5 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gm2981 similar to Apoptosis inhibitor 5 Tax_Id=10090 Gene_Symbol=Api5 Apoptosis inhibitor 5

1 6.281076 3.96 39.5 1 R.VADILTQLLQTDDSAEFNLVNNALLSIFK.MTax_Id=10090 Gene_Symbol=Ahcyl1 Putative adenosylhomocysteinase 2 Tax_Id=10090 Gene_Symbol=Ahcyl1 Protein Tax_Id=10090 Gene_Symbol=Ahcyl1 23 kDa protein

1 6.477489 3.96 84 2 R.EIEIAEQDMSALISLR.K1 6.910946 3.86 90 1 K.GESEDDFWWCIDR.C

Tax_Id=10090 Gene_Symbol=Hadhb Trifunctional enzyme subunit beta, mitochondrial Tax_Id=10090 Gene_Symbol=Gm13910 similar to Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

1 6.746629 4.14 68 2 K.DVVDYIIFGTVIQEVK.T1 6.132137 4.46 100 2 R.DFIYVSQDPK.D

Tax_Id=10090 Gene_Symbol=Slc27a5 46 kDa protein 1 6.825992 3.86 83.3 2 R.SSGASVLIVDPDLQENLEEVLPK.L1 4.625417 3.86 56.1 2 R.SSGASVLIVDPDLQENLEEVLPK.L

Tax_Id=10090 Gene_Symbol=Cdc37 Hsp90 co-chaperone Cdc37 1 10.05375 3.86 76.7 1 R.LGPGGLDPVEVYESLPEELQK.C

Tax_Id=10090 Gene_Symbol=1110002N22Rik UPF0629 protein C17orf42 homolog Tax_Id=10090 Gene_Symbol=1110002N22Rik Novel protein

1 8.177371 4.4 80 1 R.VASVAACDTDGKEPGNPLDR.LTax_Id=10090 Gene_Symbol=Pcbp2 Isoform 1 of Poly(rC)-binding protein 2 Tax_Id=10090 Gene_Symbol=Pcbp3 Pcbp3 protein Tax_Id=10090 Gene_Symbol=Pcbp3 Isoform 2 of Poly(rC)-binding protein 3 Tax_Id=10090 Gene_Symbol=Pcbp3 poly(rC) binding protein 3 Tax_Id=10090 Gene_Symbol=Pcbp2 Isoform 3 of Poly(rC)-binding protein 2 Tax_Id=10090 Gene_Symbol=Pcbp2 Isoform 2 of Poly(rC)-binding protein 2 Tax_Id=10090 Gene_Symbol=Pcbp1 Poly(rC)-binding protein 1

1 8.830273 4.14 78.1 2 R.ESTGAQVQVAGDMLPNSTER.ATax_Id=10090 Gene_Symbol=Ctsz Cathepsin Z

1 8.600524 4.4 73.1 1 K.DQDCDKFNQCGTCTEFK.ETax_Id=10090 Gene_Symbol=Cald1 Cald1 protein

1 4.522618 4.4 65.2 1 R.SGRYEVEETEVVIK.S1 6.036907 3.96 100 1 R.YEVEETEVVIK.S

Tax_Id=10090 Gene_Symbol=Cbr4 Carbonyl reductase family member 4 Tax_Id=10090 Gene_Symbol=Cbr4 15 kDa protein

1 5.65713 3.96 80 1 K.EQDVQSTFQEMEK.H

Tax_Id=10090 Gene_Symbol=Rpl14 60S ribosomal protein L14 Tax_Id=10090 Gene_Symbol=Rpl14 Ribosomal protein L14 Tax_Id=10090 Gene_Symbol=Gm9811 hypothetical protein Tax_Id=10090 Gene_Symbol=Rpl14 Putative uncharacterized protein

1 7.596201 4.46 95 1 K.LVAIVDVIDQNR.ATax_Id=10090 Gene_Symbol=Htatsf1 Isoform 1 of HIV Tat-specific factor 1 homolog

1 10.56694 4.12 73.3 1 K.AQEATTGMAFEETIDENKFEK.A1 9.577997 3.8 80 1 R.ALEPEEGNPQTEAQENGPER.E

Tax_Id=10090 Gene_Symbol=Anxa6 annexin A6 isoform b Tax_Id=10090 Gene_Symbol=Anxa6 76 kDa protein Tax_Id=10090 Gene_Symbol=Anxa6 annexin A6 isoform a Tax_Id=10090 Gene_Symbol=Anxa6 Annexin A6

1 6.852619 4.25 64.3 1 R.GSVHDFPEFDANQDAEALYTAMK.G1 6.574645 4.4 95 1 K.DLIEDLKYELTGK.F

Tax_Id=10090 Gene_Symbol=Bag3 BAG family molecular chaperone regulator 3 Tax_Id=10090 Gene_Symbol=Bag3 BCL2-associated athanogene 3

1 7.558212 3.96 90.9 1 K.ELLALDSVDPEGR.A1 5.595871 4.89 55.1 1 K.KGPENKDPQTESQQLEAK.A

Tax_Id=10090 Gene_Symbol=Pdia6 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=LOC100046302 similar to Protein disulfide isomerase associated 6

1 5.303649 3.8 43.1 2 R.ALDLFSDNAPPPELLEIINEDIAK.KTax_Id=10090 Gene_Symbol=Tor1aip1 torsin A interacting protein 1 isoform 3

1 7.19132 4.42 69.1 2 K.AAQDSDLVKHEVDQELTDGFK.NTax_Id=10090 Gene_Symbol=Rhbdd1 Rhomboid domain-containing protein 1

1 7.325523 3.86 81.5 1 R.NYDVYTAGLSEEEQLER.ATax_Id=10090 Gene_Symbol=Acaa1a;Acaa1b Putative uncharacterized protein

1 6.095857 4.14 85.2 2 R.DCLTPMGMTSENVAER.FTax_Id=10090 Gene_Symbol=Nudt7 Isoform 2 of Peroxisomal coenzyme A diphosphatase NUDT7 Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 3 of Peroxisomal coenzyme A diphosphatase NUDT7 Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 5 of Peroxisomal coenzyme A diphosphatase NUDT7 Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 4 of Peroxisomal coenzyme A diphosphatase NUDT7 Tax_Id=10090 Gene_Symbol=Nudt7 Isoform 1 of Peroxisomal coenzyme A diphosphatase NUDT7

1 8.019569 4.4 79.2 2 K.RDPVDTDDTATALR.ETax_Id=10090 Gene_Symbol=Prdx4 Peroxiredoxin 4

1 8.317435 4.72 95.7 1 K.DYGVYLEDSGHTLR.GTax_Id=10090 Gene_Symbol=Dpm1 Dolichol-phosphate mannosyltransferase Tax_Id=10090 Gene_Symbol=Dpm1 Protein Tax_Id=10090 Gene_Symbol=Dpm1 Dolichol-phosphate (Beta-D) mannosyltransferase 1

2 7.182396 3.96 65.2 1 R.EVAEQLAEIYGPDR.ITax_Id=10090 Gene_Symbol=Rpl13a;Flt3l 60S ribosomal protein L13a Tax_Id=10090 Gene_Symbol=Flt3l 48 kDa protein Tax_Id=10090 Gene_Symbol=LOC638236 similar to 60S ribosomal protein L13a Tax_Id=10090 Gene_Symbol=Rpl13a Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gm5520 similar to rat ribosomal protein L13a

1 4.733803 4.46 88.9 1 K.YQAVTATLEEK.RTax_Id=10090 Gene_Symbol=Eprs Bifunctional aminoacyl-tRNA synthetase Tax_Id=10090 Gene_Symbol=LOC633677 Glutamyl-prolyl-tRNA synthetase

3 4.852202 4.28 54.5 1 R.FDDTNPEKEKEDFEK.V

1 6.755345 4.58 48.1 2 R.TTEYHDRDEQFYWIIEALGIR.K1 5.962377 4.14 100 1 K.DQVDSAVQELLQLK.A8 6.132636 4.03 36.4 1 R.EFLWQEGHSAFATFEEAADEVLQILELYAR.V

Tax_Id=10090 Gene_Symbol=Ankfy1 Isoform 1 of Ankyrin repeat and FYVE domain-containing protein 1 Tax_Id=10090 Gene_Symbol=Ankfy1 ankyrin repeat and FYVE domain containing 1

1 5.593844 4.4 40 1 K.KYSADVMSEMAQIAEALLQAGANPNMQDSK.G48 5.922981 4.25 34.5 1 R.GADMSVPDEKGNPPLWLALASNLEDIASTLVR.H

1 9.156235 4.46 89.7 2 K.GNPPLWLALASNLEDIASTLVR.HTax_Id=10090 Gene_Symbol=Larp4 Putative uncharacterized protein

2 6.313211 8.26 35.6 1 K.DTLNPVAVPVS(79.9663)SPTATKPSPANTASPCTSNINPPR.ATax_Id=10090 Gene_Symbol=Stau1 Double-stranded RNA-binding protein Staufen homolog 1 Tax_Id=10090 Gene_Symbol=Stau1 staufen (RNA binding protein) homolog 1 isoform 2 Tax_Id=10090 Gene_Symbol=Stau1 Staufen (RNA binding protein) homolog 1 Tax_Id=10090 Gene_Symbol=Stau1 staufen (RNA binding protein) homolog 1 isoform 1

1 5.525542 4.14 81 1 R.VSVGEFVGEGEGK.S4 4.286184 4.89 69.7 2 K.KEKEPEYMLLTER.G

Tax_Id=10090 Gene_Symbol=Eef1g Elongation factor 1-gamma Tax_Id=10090 Gene_Symbol=- hypothetical protein isoform 1 Tax_Id=10090 Gene_Symbol=Gm5525 hypothetical protein isoform 1

1 8.019664 4.03 79.3 2 K.KAAAPAPEEEMDECEQALAAEPK.A1 6.862943 4.03 51.6 1 K.KAAAPAPEEEMDECEQALAAEPK.A1 10.22889 3.69 83.3 1 K.AAAPAPEEEMDECEQALAAEPK.A

Tax_Id=10090 Gene_Symbol=Akr1c14 Aldo-keto reductase family 1, member C14, isoform CRA_b 1 7.204743 3.86 88.5 3 K.LLAEAVDLCDTWEAMEK.C

Tax_Id=10090 Gene_Symbol=Akr1c6 Estradiol 17 beta-dehydrogenase 5 Tax_Id=10090 Gene_Symbol=Akr1c6 20 kDa protein

1 8.909294 3.86 81.5 2 K.LIYDAVDICDTWEAMEK.CTax_Id=10090 Gene_Symbol=Psmb5 Proteasome subunit beta type-5 Tax_Id=10090 Gene_Symbol=Psmb5 22 kDa protein Tax_Id=10090 Gene_Symbol=Psmb5 Putative uncharacterized protein

1 7.634187 7.33 78.3 1 R.DAYSGGAVNLYHVR.ETax_Id=10090 Gene_Symbol=Gm14449 similar to Mus musculus ribosomal protein L19 Tax_Id=10090 Gene_Symbol=LOC100045367 similar to ribosomal protein L19 Tax_Id=10090 Gene_Symbol=- similar to ribosomal protein L19

1 5.057903 4.46 100 3 K.LLADQAEAR.RTax_Id=10090 Gene_Symbol=Flna Isoform 1 of Filamin-A Tax_Id=10090 Gene_Symbol=Flna Filamin, alpha Tax_Id=10090 Gene_Symbol=Flna filamin, alpha Tax_Id=10090 Gene_Symbol=Flna Filamin, alpha

1 4.659928 4.72 93.8 1 K.DLAEDAPWKK.I1 8.420554 4.25 74.2 1 R.SAGQGEVLVYVEDPAGHQEEAK.V1 7.828402 4.84 87 1 R.DVDIIDHHDNTYTVK.Y1 6.812907 4.4 77.4 1 K.DAGEGLLAVQITDPEGKPK.K1 6.818018 4.14 80 1 K.DAGEGGLSLAIEGPSK.A1 5.485651 8.23 58.7 1 R.RAPS(79.9663)VANIGSHCDLSLK.I1 6.21134 4.84 55.3 1 K.THEAEIVEGENHTYCIR.F1 9.036875 3.96 73.3 1 K.DGSCGVAYVVQEPGDYEVSVK.F

Tax_Id=10090 Gene_Symbol=Opa1 Isoform 1 of Dynamin-like 120 kDa protein, mitochondrial

Tax_Id=10090 Gene_Symbol=Opa1 60 kDa protein Tax_Id=10090 Gene_Symbol=Opa1 113 kDa protein Tax_Id=10090 Gene_Symbol=Opa1 79 kDa protein Tax_Id=10090 Gene_Symbol=LOC100046998 similar to optic atrophy 1 Tax_Id=10090 Gene_Symbol=Opa1 Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial

7 4.885181 4.12 38.6 1 K.SLIDMYSEVLDVLSDYDASYNTQDHLPR.V1 5.260048 4.12 45.5 1 K.GNSSESIEAIREYEEEFFQNSK.L

Tax_Id=10090 Gene_Symbol=Akap8 A-kinase anchor protein 8 7 6.217168 4.05 35.7 1 K.AVEGEGEPAAAHSDVLTEVEGPVDTAEASSDPHTEK.L

Tax_Id=10090 Gene_Symbol=Tcp1 Isoform 1 of T-complex protein 1 subunit alpha Tax_Id=10090 Gene_Symbol=Tcp1 Isoform 2 of T-complex protein 1 subunit alpha

1 7.228804 4.12 55.8 1 K.VLCELADLQDKEVGDGTTSVVIIAAELLK.NTax_Id=10090 Gene_Symbol=Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 Tax_Id=10090 Gene_Symbol=Aldh1a1 Retinal dehydrogenase 1

4 4.89588 4.53 41.2 1 K.KFPVLNPATEEVICHVEEGDKADVDK.A1 5.484637 4.28 42.4 1 K.FPVLNPATEEVICHVEEGDKADVDK.A

Tax_Id=10090 Gene_Symbol=Lyar Cell growth-regulating nucleolar protein Tax_Id=10090 Gene_Symbol=Lyar 22 kDa protein Tax_Id=10090 Gene_Symbol=Lyar 6 kDa protein Tax_Id=10090 Gene_Symbol=Lyar 11 kDa protein Tax_Id=10090 Gene_Symbol=Lyar 15 kDa protein Tax_Id=10090 Gene_Symbol=Lyar 22 kDa protein

1 4.942719 4.25 52.8 1 R.NCECLSCIDCGKDFWGDDYK.STax_Id=10090 Gene_Symbol=Uchl5 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 Tax_Id=10090 Gene_Symbol=Uchl5 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

1 5.389228 3.86 70.8 1 R.GAQVEEIWSLEPESFEK.LTax_Id=10090 Gene_Symbol=Psmd14 26S proteasome non-ATPase regulatory subunit 14

1 7.294362 4.25 92 1 K.AVEEEDKMTPEQLAIK.NTax_Id=10090 Gene_Symbol=Gm12922 similar to hCG2016250 Tax_Id=10090 Gene_Symbol=Gm6549 similar to hCG2016250 Tax_Id=10090 Gene_Symbol=LOC671929 similar to hCG2016250 Tax_Id=10090 Gene_Symbol=Gm6549 similar to hCG2016250, isoform 3

1 6.655554 5.63 94.4 1 K.SPYQEFTDHLVK.TTax_Id=10090 Gene_Symbol=Hist1h1c Histone H1.2 Tax_Id=10090 Gene_Symbol=Hist1h1d Histone H1.3 Tax_Id=10090 Gene_Symbol=Hist1h1t histone cluster 1, H1t Tax_Id=10090 Gene_Symbol=Hist1h1e Histone H1.4

1 7.145549 4.46 86.7 1 K.ALAAAGYDVEK.NTax_Id=10090 Gene_Symbol=Ythdc2 Probable ATP-dependent RNA helicase YTHDC2

1 6.111261 3.69 47.9 1 R.AVASVSEEYDLLDDGGDAVFSQLTEK.D3 7.157859 4.28 40.3 2 K.TIDAMDAWEDLTELGYHLADLPVEPHLGK.M1 8.71478 3.86 78.6 2 R.DGQELEPQVGEQLLQLWER.L

Tax_Id=10090 Gene_Symbol=Supt5h Isoform 1 of Transcription elongation factor SPT5 1 6.490499 4.25 80 1 R.DQREEELGEYYMK.K2 4.964785 3.96 48.4 1 R.SLGGDVASDGDFLIFEGNR.Y1 5.801362 4.25 48.4 1 R.EHNFQPGDNVEVCEGELINLQGK.V

Tax_Id=10090 Gene_Symbol=Usp15 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 15 Tax_Id=10090 Gene_Symbol=Usp15 Ubiquitin carboxyl-terminal hydrolase

1 5.931719 4.25 66.7 1 K.EHLIDELDYILLPTEGWNK.L2 6.825223 4.25 44.4 2 R.FAPQFSGYQQQDCQELLAFLLDGLHEDLNR.I

Tax_Id=10090 Gene_Symbol=Ctnnd1 Isoform 3 of Catenin delta-1 Tax_Id=10090 Gene_Symbol=Ctnnd1 98 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 107 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 100 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 97 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 101 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 102 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 105 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 108 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 96 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 97 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 104 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 P120ctn Tax_Id=10090 Gene_Symbol=Ctnnd1 99 kDa protein Tax_Id=10090 Gene_Symbol=Ctnnd1 Isoform 2 of Catenin delta-1 Tax_Id=10090 Gene_Symbol=Ctnnd1 catenin, delta 1 isoform 3 Tax_Id=10090 Gene_Symbol=Ctnnd1 Isoform 1 of Catenin delta-1

14 4.449254 4.12 37.3 1 R.SYEDMIGEEVPPDQYYWAPLAQHER.G1 5.831264 4.4 72.4 1 R.DMDLTEVITGTLWNLSSHDSIK.M

Tax_Id=10090 Gene_Symbol=Ftsj3 Putative rRNA methyltransferase 3 1 7.50799 3.69 77.4 1 K.DGFSGIEDDADEALEISQAQLLYK.S1 7.078705 3.69 71.4 1 R.YAFNEEEGELPEWFAQEEK.Q

Tax_Id=10090 Gene_Symbol=Riok2 Serine/threonine-protein kinase RIO2 1 5.649912 4.03 38.4 1 K.DGGLPEESAHVSSFEVTALSQAVEEMER.Q

Tax_Id=10090 Gene_Symbol=Ephx1 Epoxide hydrolase 1, microsomal, isoform CRA_c Tax_Id=10090 Gene_Symbol=Ephx1 16 kDa protein Tax_Id=10090 Gene_Symbol=Ephx1 51 kDa protein Tax_Id=10090 Gene_Symbol=Ephx1 Epoxide hydrolase 1

3 7.221626 4.63 50 4 K.EDESIRPFKVETSDEEIKDLHQR.ITax_Id=10090 Gene_Symbol=Bag5 BAG family molecular chaperone regulator 5 Tax_Id=10090 Gene_Symbol=LOC100047042 similar to BCL2-associated athanogene 5

1 8.63644 4.14 54.8 1 K.AVWEILGNLSEILGEVLSFGGNR.TTax_Id=10090 Gene_Symbol=Suclg2 Isoform 1 of Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Tax_Id=10090 Gene_Symbol=Suclg2 Isoform 2 of Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

8 4.117557 4.28 41.4 1 R.QKDIFAMDDKSENEPIENEAAR.YTax_Id=10090 Gene_Symbol=Habp4 hyaluronic acid binding protein 4

1 7.574329 3.64 88.9 1 K.VPELEVEEENQVQEMTLDEWK.NTax_Id=10090 Gene_Symbol=Mrpl1 39S ribosomal protein L1, mitochondrial Tax_Id=10090 Gene_Symbol=Mrpl1 mitochondrial ribosomal protein L1 isoform 2

1 8.574249 4.25 85.7 1 K.SYTYMESDPEDDVYLKR.LTax_Id=10090 Gene_Symbol=Ldha L-lactate dehydrogenase A chain Tax_Id=10090 Gene_Symbol=Ldha 30 kDa protein Tax_Id=10090 Gene_Symbol=Ldha Ldha protein Tax_Id=10090 Gene_Symbol=Ldha lactate dehydrogenase A isoform 2

1 6.715701 4.72 87.5 3 K.DQLIVNLLKEEQAPQNK.ITax_Id=10090 Gene_Symbol=Grpel1 GrpE protein homolog 1, mitochondrial

1 4.809484 3.96 94.4 1 K.DLLEVADILEK.ATax_Id=10090 Gene_Symbol=Serpinb6a Serpin B6 Tax_Id=10090 Gene_Symbol=Serpinb6a serine (or cysteine) proteinase inhibitor, clade B, member 6a isoform a Tax_Id=10090 Gene_Symbol=Serpinb6a Putative uncharacterized protein

1 10.30345 3.69 96.4 2 K.FYEAELEELDFQGATEESR.QTax_Id=10090 Gene_Symbol=Ssr1 Translocon-associated protein alpha, muscle specific isoform Tax_Id=10090 Gene_Symbol=Ssr1 Translocon-associated protein subunit alpha Tax_Id=10090 Gene_Symbol=LOC636537 similar to translocon-associated protein alpha, muscle specific

1 7.47655 3.96 79.2 1 K.GTEDFIVESLDASFR.YTax_Id=10090 Gene_Symbol=Gm7204 similar to MSP23 isoform 2 Tax_Id=10090 Gene_Symbol=Gm7204 similar to MSP23 isoform 1 Tax_Id=10090 Gene_Symbol=Prdx1 Peroxiredoxin 1 Tax_Id=10090 Gene_Symbol=Prdx1 Peroxiredoxin 1

1 7.011422 6.56 100 1 R.LVQAFQFTDK.HTax_Id=10090 Gene_Symbol=Srrm2 Isoform 2 of Serine/arginine repetitive matrix protein 2

1 7.805557 4.58 75.9 1 K.EETPGQRPVVTETHQLAELNEK.K27 4.904378 4.58 37.7 1 K.EETPGQRPVVTETHQLAELNEK.K

1 7.760741 6.56 53.1 1 K.S(79.9663)GTPPRPGSVTNMQADECTATPQR.Q1 8.303785 6.56 55.4 1 K.SGT(79.9663)PPRPGSVTNMQADECTATPQR.Q1 6.975522 6.56 48.4 1 K.S(79.9663)GTPPRPGSVTNMQADECTAT(79.9663)PQR.Q1 6.36395 6.56 57.7 1 R.DKFS(79.9663)PTQDRPESSTVLK.V1 5.777978 3.96 61.5 2 K.SLLPNSSQDELMEVEK.S2 9.438515 3.86 45.2 1 K.EELNGSFLNQTEADPSVDMK.E1 4.987989 12 69.2 3 R.NHSGS(79.9663)RTPPVALSSSR.M1 5.137278 8.26 62.5 1 R.CRS(79.9663)PGMLEPLGSAR.T

Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 2 of Dynamin-1-like protein Tax_Id=10090 Gene_Symbol=Dnm1l dynamin 1-like isoform a Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 3 of Dynamin-1-like protein Tax_Id=10090 Gene_Symbol=Dnm1l Isoform 1 of Dynamin-1-like protein

2 4.115016 4.03 51.9 1 K.LYTDFDEIRQEIENETER.I1 8.265374 3.86 89.3 1 K.SSLLDDLLTESEDMAQR.R

Tax_Id=10090 Gene_Symbol=Acsm1 Isoform 1 of Acyl-coenzyme A synthetase ACSM1, mitochondrial Tax_Id=10090 Gene_Symbol=Acsm1 20 kDa protein Tax_Id=10090 Gene_Symbol=Acsm1 Isoform 2 of Acyl-coenzyme A synthetase ACSM1, mitochondrial

33 6.908852 3.89 34.3 1 R.WNDHDSPEEFNFASDVLDYWAQMEEEGK.RTax_Id=10090 Gene_Symbol=Atp5a1 ATP synthase subunit alpha, mitochondrial Tax_Id=10090 Gene_Symbol=Atp5a1 55 kDa protein

1 5.06188 4.14 66.7 2 R.TGAIVDVPVGEELLGR.V1 7.28538 5.63 88.9 1 K.HALIIYDDLSK.Q

Tax_Id=10090 Gene_Symbol=Prpf31 Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp31 1 8.554687 4.12 78.6 1 R.MSFGEIEEDAYQEDLGFSLGHLGK.S1 7.105852 4.12 51.6 2 R.MSFGEIEEDAYQEDLGFSLGHLGK.S

Tax_Id=10090 Gene_Symbol=Grwd1 Glutamate-rich WD repeat-containing protein 1 Tax_Id=10090 Gene_Symbol=Grwd1 11 kDa protein Tax_Id=10090 Gene_Symbol=Grwd1 46 kDa protein

1 9.987804 4.12 53.8 2 R.GPPLSEGEELVMDEEAYVLYHR.ATax_Id=10090 Gene_Symbol=Rnmt Isoform 3 of mRNA cap guanine-N7 methyltransferase Tax_Id=10090 Gene_Symbol=Rnmt 14 kDa protein

Tax_Id=10090 Gene_Symbol=Rnmt 23 kDa protein Tax_Id=10090 Gene_Symbol=Rnmt Isoform 2 of mRNA cap guanine-N7 methyltransferase Tax_Id=10090 Gene_Symbol=Rnmt Isoform 1 of mRNA cap guanine-N7 methyltransferase

1 8.312731 3.86 86.7 2 K.EFGEDLVEQNSSYVQDSPSK.KTax_Id=10090 Gene_Symbol=Stub1 STIP1 homology and U box-containing protein 1

1 7.721381 3.86 95.8 1 K.YMADMDELFSQVDEK.RTax_Id=10090 Gene_Symbol=Tra2b Isoform 1 of Transformer-2 protein homolog beta

1 7.977355 4.14 100 1 R.GFAFVYFENVDDAK.ETax_Id=10090 Gene_Symbol=Myo9b Isoform 1 of Myosin-IXb Tax_Id=10090 Gene_Symbol=Myo9b myosin IXb isoform 2 Tax_Id=10090 Gene_Symbol=Myo9b myosin IXb isoform 1 Tax_Id=10090 Gene_Symbol=Myo9b Isoform 3 of Myosin-IXb Tax_Id=10090 Gene_Symbol=Myo9b Isoform 2 of Myosin-IXb

1 7.184186 4.25 55.2 1 K.ESGGEEWVLDASDSPVHR.V1 6.226112 4.72 72.7 1 R.RAS(79.9663)LEIGESFPEGTK.G1 8.835061 3.96 64.3 1 R.EDGLEAWTETTAPSSSK.Q1 5.680897 4.4 71.4 1 R.GEKDTNLVLNVFQSLLDEFTR.S1 9.478665 4.14 93.1 1 K.DTNLVLNVFQSLLDEFTR.S

10 4.92132 4.7 34.2 2 R.AVELPEKQEQLSAIYAVLDHLPEANHTSLER.LTax_Id=10090 Gene_Symbol=Ubap2l Isoform 5 of Ubiquitin-associated protein 2-like Tax_Id=10090 Gene_Symbol=Ubap2l Nice-4 protein homolog isoform 6 Tax_Id=10090 Gene_Symbol=Ubap2l Nice-4 protein homolog isoform 2 Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 1 of Ubiquitin-associated protein 2-like Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 3 of Ubiquitin-associated protein 2-like Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 2 of Ubiquitin-associated protein 2-like Tax_Id=10090 Gene_Symbol=Ubap2l Isoform 4 of Ubiquitin-associated protein 2-like

1 8.685661 4.25 92 1 R.LAQMISDHNDADFEEK.V9 4.768975 4.25 61 1 R.LAQMISDHNDADFEEK.V1 8.835414 4.4 72.4 1 K.NQDECVIALHDCNGDVNR.A1 7.046501 3.69 81.5 1 R.TATEEWGTEDWNEDLSETK.I

Tax_Id=10090 Gene_Symbol=Kpna3 Importin subunit alpha-3 6 6.100691 3.8 39.1 1 K.NILIMAGDEASTIAEIIEECGGLEK.I

Tax_Id=10090 Gene_Symbol=Ddi2 Protein DDI1 homolog 2 1 6.036422 4.03 62 2 R.EDIRPEEIADQELAEAIQK.S

Tax_Id=10090 Gene_Symbol=Gnai3 Guanine nucleotide-binding protein G(k) subunit alpha 1 8.633833 3.96 71.4 1 R.EYQLNDSASYYLNDLDR.I

Tax_Id=10090 Gene_Symbol=Ctsl Cathepsin L1 1 7.25418 3.86 57.7 1 K.ENGGLDSEESYPYEAK.D

Tax_Id=10090 Gene_Symbol=Lrpprc Leucine-rich PPR motif-containing protein, mitochondrial Tax_Id=10090 Gene_Symbol=Lrpprc 147 kDa protein

34 5.866433 4.4 33.8 3 R.YCSKPPGPAEAVGYFLYNLIDSMSDSEVQAK.E1 7.512539 4.14 84 1 K.TSQVTSSDLESTLEK.L1 6.987329 3.96 57.1 2 K.DVGEPVPFPEPPESFAFYIK.Q

Tax_Id=10090 Gene_Symbol=Zfr Zinc finger RNA-binding protein 41 5.519906 4.12 30.9 1 K.QDAGSEPVTPASLAALQSDVQPVGHDYVEEVR.N

1 4.203909 4.25 67.9 1 R.EGDVTSGMVKDPPDVLDR.QTax_Id=10090 Gene_Symbol=Supt5h Isoform 2 of Transcription elongation factor SPT5

2 4.964785 3.96 48.4 1 R.SLGGDVASDGDFLIFEGNR.Y

1 5.801362 4.25 48.4 1 R.EHNFQPGDNVEVCEGELINLQGK.VTax_Id=10090 Gene_Symbol=Sf3b2 splicing factor 3b, subunit 2

1 7.091798 3.86 76.7 1 K.IEEAMDGSETPQLFTVLPEK.R1 8.32144 4.42 60.7 1 R.EQQAQVEKEDFSDMVAEHAAK.Q

Tax_Id=10090 Gene_Symbol=Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 precursor 1 8.237451 4.46 88.5 1 R.DDGAAILVAVSNMVQK.I1 9.507913 3.86 60.7 1 R.YDDIEETNYFQQASELAK.L

Tax_Id=10090 Gene_Symbol=Rbm47 Isoform 1 of RNA-binding protein 47 Tax_Id=10090 Gene_Symbol=Rbm47 Isoform 2 of RNA-binding protein 47

1 4.878443 4.03 41.7 2 R.IQLWGHQIAVDWAEPEIDVDEDVMQTVK.ITax_Id=10090 Gene_Symbol=Sf3b4 Splicing factor 3B subunit 4 Tax_Id=10090 Gene_Symbol=Gm7935 similar to Splicing factor 3b, subunit 4

1 10.20874 3.86 81.2 2 K.NLDVGANIFIGNLDPEIDEK.LTax_Id=10090 Gene_Symbol=Ybx2 Isoform 1 of Y-box-binding protein 2 Tax_Id=10090 Gene_Symbol=Ybx2 Y box protein 2 Tax_Id=10090 Gene_Symbol=LOC100045903 similar to Y box protein 2 Tax_Id=10090 Gene_Symbol=Ybx2 Isoform 2 of Y-box-binding protein 2

1 9.728408 3.8 92.3 2 R.SVGDGETVEFDVVEGEK.GTax_Id=10090 Gene_Symbol=Tpi1 triosephosphate isomerase 1

1 6.069138 5.63 77.3 1 K.DLGATWVVLGHSER.RTax_Id=10090 Gene_Symbol=LOC677576 similar to 3-methylcrotonyl-CoA carboxylase alpha subunit

1 5.990706 4.72 85 1 K.KSFNDDAMLIEK.C1 5.286065 4.14 100 1 K.SFNDDAMLIEK.C

Tax_Id=10090 Gene_Symbol=Lonp2 Isoform 1 of Peroxisomal Lon protease homolog 2 Tax_Id=10090 Gene_Symbol=Lonp2 Isoform 2 of Peroxisomal Lon protease homolog 2

1 4.419359 4.4 77.3 1 K.SREELGELSEQFYR.Y1 5.030576 3.79 51.7 1 R.IPHIPGTLEDEEEEEDNDDIVMLEK.K

Tax_Id=10090 Gene_Symbol=Utp14a Isoform 1 of U3 small nucleolar RNA-associated protein 14 homolog A 1 7.149059 4.25 81.8 1 R.KVDPDAALEELEK.M1 5.954779 3.86 70 1 R.TPSVTSLALPTTVEELEDEGAR.D

Tax_Id=10090 Gene_Symbol=Gckr Glucokinase regulatory protein 1 6.785445 4.12 41.8 1 R.YQHVIETPEPGEWELSGYEAAVPITEK.S

Tax_Id=10090 Gene_Symbol=Prpf19 Isoform 2 of Pre-mRNA-processing factor 19 Tax_Id=10090 Gene_Symbol=Prpf19 Isoform 1 of Pre-mRNA-processing factor 19

5 4.574637 3.86 42.9 1 K.YIAENGTDPINNQPLSEEQLIDIK.VTax_Id=10090 Gene_Symbol=Gnl3 Isoform 2 of Guanine nucleotide-binding protein-like 3

1 3.914337 4.19 46 1 R.KLEVSPGDEQSNVETREESDEPK.RTax_Id=10090 Gene_Symbol=Gsr Isoform Mitochondrial of Glutathione reductase, mitochondrial Tax_Id=10090 Gene_Symbol=Gsr Isoform Cytoplasmic of Glutathione reductase, mitochondrial

1 8.910794 3.86 68.8 1 R.NFDSLISSNCTEELENAGVEVLK.FTax_Id=10090 Gene_Symbol=Aatf Isoform 3 of Protein AATF

1 4.993258 4.19 56.1 1 R.VIDRFDEGEEEKDDLAVSSIR.KTax_Id=10090 Gene_Symbol=Krt42 Keratin, type I cytoskeletal 42

1 6.356577 3.96 95 1 R.ALEEANADLEVK.I1 6.362315 4.14 92.9 1 K.DAEEWFFTK.T

Tax_Id=10090 Gene_Symbol=Shq1 Isoform 2 of Protein SHQ1 homolog Tax_Id=10090 Gene_Symbol=Shq1 Isoform 1 of Protein SHQ1 homolog

2 5.835946 4.03 49.1 1 K.FDPDHYLADFFEDEAVEQILK.Y

Tax_Id=10090 Gene_Symbol=Dbnl Isoform 2 of Drebrin-like protein Tax_Id=10090 Gene_Symbol=Dbnl Isoform 3 of Drebrin-like protein Tax_Id=10090 Gene_Symbol=Dbnl Isoform 1 of Drebrin-like protein

1 11.33226 3.86 73.3 2 R.VAGTGEGGLEELVEELNSGK.VTax_Id=10090 Gene_Symbol=Oat Ornithine aminotransferase, mitochondrial

1 8.297511 3.8 70 1 R.IAIAALEVLEEENLAENADK.MTax_Id=10090 Gene_Symbol=Polr1c Polr1c protein Tax_Id=10090 Gene_Symbol=Polr1c 30 kDa protein Tax_Id=10090 Gene_Symbol=Polr1c 29 kDa protein Tax_Id=10090 Gene_Symbol=Polr1c DNA-directed RNA polymerases I and III subunit RPAC1

1 10.11469 3.86 88.5 1 R.NQGEEEGTEIDTLQFR.LTax_Id=10090 Gene_Symbol=Eif3i Eukaryotic translation initiation factor 3 subunit I

1 9.075554 3.96 69.6 5 R.IHYFDPQYFEFEFEA.-Tax_Id=10090 Gene_Symbol=Tor1aip1 Putative uncharacterized protein

1 8.648098 3.86 91.3 2 R.FSEEPAEVYGDFEPR.ATax_Id=10090 Gene_Symbol=Sdhb Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

3 5.160664 4.25 63.9 1 R.WMIDSRDDFTEER.LTax_Id=10090 Gene_Symbol=Arhgef2 Isoform 1 of Rho guanine nucleotide exchange factor 2 Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 4 of Rho guanine nucleotide exchange factor 2 Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 5 of Rho guanine nucleotide exchange factor 2

1 6.247036 4.25 83.3 1 K.ELLSNVDQDVHELEK.E1 6.446993 4.72 43.2 2 R.SPQEEVLQPLINLYGLLHGLQAVVVQQER.L

Tax_Id=10090 Gene_Symbol=Nop14 probable nucleolar complex protein 14 1 6.435698 4.25 90 1 R.DAMHEMEEMIETK.G8 5.045663 4.4 39.7 1 K.HLADCSLPQELQELAQSILSAMEGQK.Q

Tax_Id=10090 Gene_Symbol=Ctnnb1 Catenin beta-1 Tax_Id=10090 Gene_Symbol=Ctnnb1 Putative uncharacterized protein

2 6.788198 4.28 36.8 1 R.VAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSR.N2 6.117282 4.28 33.8 1 R.VAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSR.N

Tax_Id=10090 Gene_Symbol=Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 isoform 1 Tax_Id=10090 Gene_Symbol=Ahcyl2 Adenosylhomocysteinase (Fragment) Tax_Id=10090 Gene_Symbol=Ahcyl2 27 kDa protein Tax_Id=10090 Gene_Symbol=Ahcyl2 57 kDa protein Tax_Id=10090 Gene_Symbol=Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 isoform 2 Tax_Id=10090 Gene_Symbol=Ahcyl2 Isoform 2 of Putative adenosylhomocysteinase 3

1 5.937253 3.96 69.2 2 R.EIEIAEQEMPALMALR.K1 6.910946 3.86 90 1 K.GESEDDFWWCIDR.C

Tax_Id=10090 Gene_Symbol=Sars Seryl-aminoacyl-tRNA synthetase, isoform CRA_b Tax_Id=10090 Gene_Symbol=Sars Seryl-tRNA synthetase, cytoplasmic

2 6.683171 4.42 43.1 1 R.EIGNLLHPSVPISNDEDADNKVER.ITax_Id=10090 Gene_Symbol=Cyp27a1 Sterol 26-hydroxylase, mitochondrial

1 4.837046 4.25 46.9 1 R.LLKPDEAALYTDALNEVISDFITR.LTax_Id=10090 Gene_Symbol=Tom1l2 Isoform 1 of TOM1-like protein 2 Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 2 of TOM1-like protein 2 Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 3 of TOM1-like protein 2 Tax_Id=10090 Gene_Symbol=Tom1l2 Target of myb1-like 2 Tax_Id=10090 Gene_Symbol=Tom1l2 Target of myb1-like 2 Tax_Id=10090 Gene_Symbol=Tom1l2 Target of myb1-like 2

Tax_Id=10090 Gene_Symbol=Tom1l2 Isoform 4 of TOM1-like protein 2 1 4.37206 4.12 46.7 1 R.VSNEEVTEELLHVNDDLNNVFLR.Y

Tax_Id=10090 Gene_Symbol=Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 Tax_Id=10090 Gene_Symbol=Ifit1 Putative uncharacterized protein

1 6.261303 4.89 58.9 1 R.RQDNVQELAQQAIHEFQETLK.LTax_Id=10090 Gene_Symbol=Tuba8 Tubulin alpha-8 chain Tax_Id=10090 Gene_Symbol=Tuba3b;Tuba3a Putative uncharacterized protein

1 9.820419 4.25 85.7 2 R.AFVHWYVGEGMEEGEFSEAR.ETax_Id=10090 Gene_Symbol=Cpox Coproporphyrinogen-III oxidase, mitochondrial

48 5.033721 4.25 45.1 1 R.GIGGIFFDDLDSPSKEEAFR.FTax_Id=10090 Gene_Symbol=Apoe Apolipoprotein E

8 5.08536 3.86 54.5 1 K.ELEEQLGPVAEETR.ATax_Id=10090 Gene_Symbol=Hsd17b12 Isoform 1 of Estradiol 17-beta-dehydrogenase 12

1 9.18304 3.96 100 2 R.TIAVDFSLDDIYDK.ITax_Id=10090 Gene_Symbol=Rbm6 Rbm6 protein

1 4.772573 4.84 53.1 1 R.DGPHGDYQGGEGPGHDFR.G1 8.005361 3.95 42.9 2 K.LSGGEQQSSDAGLFKEEGDLDFLGQQDTDYR.S

Tax_Id=10090 Gene_Symbol=Mtap4 Isoform 1 of Microtubule-associated protein 4 Tax_Id=10090 Gene_Symbol=Mtap4 microtubule-associated protein 4 Tax_Id=10090 Gene_Symbol=Mtap4 Isoform 3 of Microtubule-associated protein 4

9 6.540067 3.69 50 2 R.DFMAALEAEPYDDIVGETVEK.T1 5.705069 4.12 47.3 1 K.DVTLPLEAERPLVTDMTPSLETEMTLGK.E

Tax_Id=10090 Gene_Symbol=Dus3l Isoform 1 of tRNA-dihydrouridine synthase 3-like Tax_Id=10090 Gene_Symbol=Dus3l Isoform 2 of tRNA-dihydrouridine synthase 3-like

1 6.573335 4.28 43.2 1 R.FHEYLDGDKQEGACQEVPTGDPAEPGAK.RTax_Id=10090 Gene_Symbol=Cct7 T-complex protein 1 subunit eta

1 9.645261 4.42 42.6 1 R.VHTVEDYQAIVDAEWNILYDKLEK.ITax_Id=10090 Gene_Symbol=Hmgcs1;LOC100040592 Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1 6.056027 4.14 100 2 R.LEVGTETIIDK.S1 5.517194 4.25 89.5 1 K.LEDTYFDRDVEK.A

Tax_Id=10090 Gene_Symbol=Selenbp2 Selenium-binding protein 2 Tax_Id=10090 Gene_Symbol=LOC100044204;Selenbp1 Selenium-binding protein 1

1 7.859649 3.96 80.6 1 K.GWMLPEMPGLITDILLSLDDR.FTax_Id=10090 Gene_Symbol=Uqcrc2 Cytochrome b-c1 complex subunit 2, mitochondrial

1 4.687386 3.96 57.1 2 R.SDIEILMEFLLNVTTAPEFR.R8 6.642366 3.96 45.3 1 R.SDIEILMEFLLNVTTAPEFR.R

Tax_Id=10090 Gene_Symbol=Rcc1 Regulator of chromosome condensation 1 Tax_Id=10090 Gene_Symbol=Rcc1 Regulator of chromosome condensation

1 6.034043 4.25 60 1 R.DTSVEGSEMVPGKVELQEK.VTax_Id=10090 Gene_Symbol=Rdx radixin isoform b Tax_Id=10090 Gene_Symbol=Rdx radixin isoform a Tax_Id=10090 Gene_Symbol=Rdx Radixin

1 6.022758 3.86 64.3 2 K.FFPEDVSEELIQEITQR.LTax_Id=10090 Gene_Symbol=Ctsd Cathepsin D Tax_Id=10090 Gene_Symbol=Ctsd Protein Tax_Id=10090 Gene_Symbol=Ctsd Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Ctsd Putative uncharacterized protein

1 7.898258 3.96 75 1 R.DPEGQPGGELMLGGTDSK.Y

Tax_Id=10090 Gene_Symbol=G3bp1 Putative uncharacterized protein 1 6.446626 4.14 67.9 1 K.STS(79.9663)PAPADVAPAQEDLR.T1 7.320084 4.14 75.9 1 K.S(79.9663)TSPAPADVAPAQEDLR.T

Tax_Id=10090 Gene_Symbol=Fn1 Fn1 protein 1 8.357416 4.25 74.1 3 R.GFNCESKPEPEETCFDK.Y

Tax_Id=10090 Gene_Symbol=Sept2 Septin-2 Tax_Id=10090 Gene_Symbol=Sept2 septin 2 b

4 5.490563 4.57 57.1 1 R.KVENEDMNKDQILLEK.ETax_Id=10090 Gene_Symbol=Cep170 Isoform 3 of Centrosomal protein of 170 kDa

1 6.731749 3.8 75 1 R.FNPDGEEEDVTVHE.-Tax_Id=10090 Gene_Symbol=Slc25a5 ADP/ATP translocase 2 Tax_Id=10090 Gene_Symbol=- similar to adenine nucleotide translocase isoform 1 Tax_Id=10090 Gene_Symbol=Gm5529 similar to adenine nucleotide translocase

1 7.141141 6.56 95.5 1 K.DFLAGGVAAAISK.TTax_Id=10090 Gene_Symbol=Gm16406 similar to ribosomal protein S6

1 5.403587 6.56 100 1 K.KNKEEAAEYAK.LTax_Id=10090 Gene_Symbol=Eif3a Eukaryotic translation initiation factor 3 subunit A

6 3.710191 4.4 44.6 1 R.EQPEKEPELQQYVPQLQNNTILR.L1 7.396213 3.95 96.3 1 K.AFKDIDIEDLEELDPDFIMAK.Q1 5.244528 3.95 52.7 1 K.AFKDIDIEDLEELDPDFIMAK.Q1 7.906724 3.64 60.7 2 K.DIDIEDLEELDPDFIMAK.Q1 6.867305 4.12 100 1 R.VKDMDLWEQQEEER.I1 5.20794 4.12 78.4 1 R.VKDMDLWEQQEEER.I

Tax_Id=10090 Gene_Symbol=Myo6 MKIAA0389 protein Tax_Id=10090 Gene_Symbol=Myo6 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Myo6 146 kDa protein Tax_Id=10090 Gene_Symbol=Myo6 myosin VI

1 7.65589 3.96 88.5 1 R.YLTESYGTGQDIDDR.I1 9.084539 3.86 78.6 1 K.SAPSLEYCAELLGLDQDDLR.V1 10.49902 3.86 73.3 1 R.IAQNESELISDEAQGDMALR.S

Tax_Id=10090 Gene_Symbol=Cth Cystathionine gamma-lyase 1 7.454086 3.69 57.1 1 R.LSVGLEDEQDLLEDLDR.A

Tax_Id=10090 Gene_Symbol=LOC100045982 similar to MOSC domain-containing protein 1, mitochondrial isoform 2 Tax_Id=10090 Gene_Symbol=Mosc1 MOCO sulphurase C-terminal domain containing 1

1 8.750797 4.14 100 1 R.DCGEDAAQWVSSFLK.MTax_Id=10090 Gene_Symbol=Fbl;LOC100044829 rRNA 2'-O-methyltransferase fibrillarin Tax_Id=10090 Gene_Symbol=LOC100044829 similar to Fibrillarin isoform 2

1 4.970608 4.89 73.7 1 K.RVSISEGDDKIEYR.A1 7.266667 4.4 90.5 1 R.VSISEGDDKIEYR.A

Tax_Id=10090 Gene_Symbol=Psma3 Proteasome subunit alpha type-3 Tax_Id=10090 Gene_Symbol=Psma3 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gm13835 similar to proteasome alpha7/C8 subunit

1 5.460603 4.89 77.8 1 K.DIREEAEKYAK.E21 5.350371 4.89 69 1 K.DIREEAEKYAK.E

Tax_Id=10090 Gene_Symbol=Myo1b myosin IB isoform 2 Tax_Id=10090 Gene_Symbol=Myo1b Isoform 2 of Myosin-Ib Tax_Id=10090 Gene_Symbol=Myo1b Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Myo1b myosin IB isoform 1

35 5.147042 4.4 35.3 1 R.NAMQIVGFLDHEAEAVLEVVAAVLK.L1 6.755528 4.25 70.4 1 R.SGVEVLFNELEIPVEEHSFGR.S1 4.557912 4.25 52.9 1 R.SGVEVLFNELEIPVEEHSFGR.S

Tax_Id=10090 Gene_Symbol=Ppfibp1 Isoform 3 of Liprin-beta-1 Tax_Id=10090 Gene_Symbol=LOC100046025 similar to mKIAA1230 protein isoform 2 Tax_Id=10090 Gene_Symbol=LOC100046025 similar to mKIAA1230 protein isoform 3 Tax_Id=10090 Gene_Symbol=LOC100046025 similar to mKIAA1230 protein isoform 1 Tax_Id=10090 Gene_Symbol=Ppfibp1 Isoform 1 of Liprin-beta-1

1 6.124469 4.12 46 1 R.LENDKESLVLQVSVLTDQVEAQGEK.I1 6.580382 4.14 84 1 R.DAMELPDYVLLTATAK.V

Tax_Id=10090 Gene_Symbol=Eif3c Eukaryotic translation initiation factor 3 subunit C 1 9.629309 4.03 87.5 1 R.ILADLEDYLNELWEDKEGK.K1 8.935817 3.69 90.3 2 K.SEQDQAENEGEDSAVLMER.L

Tax_Id=10090 Gene_Symbol=A1cf Isoform 1 of APOBEC1 complementation factor Tax_Id=10090 Gene_Symbol=A1cf Isoform 2 of APOBEC1 complementation factor Tax_Id=10090 Gene_Symbol=A1cf Isoform 3 of APOBEC1 complementation factor

1 7.586579 4.57 47.7 1 R.NLMLSTSEEMIEKEFNSIKPGAVER.VTax_Id=10090 Gene_Symbol=Sptlc1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Sptlc1 Serine palmitoyltransferase 1

1 4.665822 4.12 52.9 2 K.EKEELIEEWQPEPLVPPVSK.NTax_Id=10090 Gene_Symbol=Krt7 Keratin, type II cytoskeletal 7 no description

1 8.335616 4.14 74.2 1 A.ELQSQISDTSVVLSMDNSR.STax_Id=10090 Gene_Symbol=Ruvbl1 RuvB-like 1 Tax_Id=10090 Gene_Symbol=Ruvbl1 Putative uncharacterized protein

1 6.50701 4.28 61.2 1 K.DSIEKEHVEEISELFYDAK.STax_Id=10090 Gene_Symbol=Ahcy;Gm9826 Adenosylhomocysteinase Tax_Id=10090 Gene_Symbol=LOC677344 similar to S-adenosylhomocysteine hydrolase

1 7.777085 4.25 75 2 K.GETDEEYLWCIEQTLHFK.DTax_Id=10090 Gene_Symbol=Mapk1 Mitogen-activated protein kinase 1 Tax_Id=10090 Gene_Symbol=Mapk3 42 kDa protein Tax_Id=10090 Gene_Symbol=Mapk3 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Mapk1 ERK2 Tax_Id=10090 Gene_Symbol=Mapk3 Mitogen-activated protein kinase 3

1 8.978431 3.96 87.5 3 K.DVYIVQDLMETDLYK.LTax_Id=10090 Gene_Symbol=Eif4a2 eukaryotic translation initiation factor 4A2 isoform b

1 8.322711 3.96 100 1 K.MFVLDEADEMLSR.GTax_Id=10090 Gene_Symbol=Cope Coatomer subunit epsilon Tax_Id=10090 Gene_Symbol=Cope 26 kDa protein Tax_Id=10090 Gene_Symbol=Cope 25 kDa protein

1 5.552986 4.4 90 1 R.DSIVLELDREMSR.STax_Id=10090 Gene_Symbol=Pgam5 Isoform 2 of Serine/threonine-protein phosphatase PGAM5, mitochondrial Tax_Id=10090 Gene_Symbol=Pgam5 Isoform 1 of Serine/threonine-protein phosphatase PGAM5, mitochondrial Tax_Id=10090 Gene_Symbol=Pgam5 29 kDa protein

1 7.354112 3.96 90 3 R.NVESGEDELTSR.LTax_Id=10090 Gene_Symbol=Pdcd6ip Isoform 3 of Programmed cell death 6-interacting protein Tax_Id=10090 Gene_Symbol=Pdcd6ip programmed cell death 6 interacting protein isoform 2 Tax_Id=10090 Gene_Symbol=Pdcd6ip programmed cell death 6 interacting protein isoform 1

Tax_Id=10090 Gene_Symbol=Pdcd6ip programmed cell death 6 interacting protein isoform 3 1 9.266639 3.8 100 4 R.LLDEEEATDNDLR.A9 6.084542 3.86 43.1 1 K.FLTALAQDGVINEEALSVTELDR.I

Tax_Id=10090 Gene_Symbol=Trap1 Heat shock protein 75 kDa, mitochondrial 1 6.216199 3.69 42.7 2 R.ESEPELAQLLVDQIYENAMIAAGLVDDPR.A

Tax_Id=10090 Gene_Symbol=Cdc40 Pre-mRNA-processing factor 17 1 6.481843 4.31 49.2 1 K.YVDEKDVAKPSEEEQKELDEITAK.R

Tax_Id=10090 Gene_Symbol=Nop56 Nucleolar protein 56 Tax_Id=10090 Gene_Symbol=Nop56 Nucleolar protein 5A

1 9.420426 3.8 86.2 1 R.LAALALASSENSSTPEECEEVNEK.S1 5.98347 3.8 52.3 1 R.LAALALASSENSSTPEECEEVNEK.S

Tax_Id=10090 Gene_Symbol=Eif2ak2 Interferon-induced, double-stranded RNA-activated protein kinase 1 5.631155 3.86 62.1 1 R.FNSDFEDIEEIGLGGFGQVFK.A

Tax_Id=10090 Gene_Symbol=Znhit6 Isoform 1 of Box C/D snoRNA protein 1 Tax_Id=10090 Gene_Symbol=Znhit6 MCG7779, isoform CRA_c

1 5.664299 4.19 57.7 1 K.VKEEVTDWEEVKEEDLTIK.QTax_Id=10090 Gene_Symbol=Lrrfip2 Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 Tax_Id=10090 Gene_Symbol=Lrrfip2 Isoform 2 of Leucine-rich repeat flightless-interacting protein 2 Tax_Id=10090 Gene_Symbol=Lrrfip2 Putative uncharacterized protein

1 6.590194 4.42 59.3 1 K.TAAENAEKIEDELKAER.R1 4.673933 4.42 67.4 1 K.TAAENAEKIEDELKAER.R

Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-1 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-3 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tax_Id=10090 Gene_Symbol=Gnas 44 kDa protein Tax_Id=10090 Gene_Symbol=Gnas Isoform XLas-4 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tax_Id=10090 Gene_Symbol=Gnas Isoform XLas-1 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1 6.797296 3.86 63 1 R.YTTPEDATPEPGEDPR.VTax_Id=10090 Gene_Symbol=Psmd6 26S proteasome non-ATPase regulatory subunit 6

1 4.297428 4.89 64.3 1 K.IDKVNEIVETNRPDSK.NTax_Id=10090 Gene_Symbol=Rad23b UV excision repair protein RAD23 homolog B Tax_Id=10090 Gene_Symbol=Rad23b RAD23b homolog

27 4.595522 3.34 42.3 3 K.NENLAANFLLQQNFDED.-Tax_Id=10090 Gene_Symbol=Ndrg1 Protein NDRG1

1 5.325281 4.58 62.5 1 R.ELHDVDLAEVKPLVEK.GTax_Id=10090 Gene_Symbol=Rnps1 RNA/DNA-binding protein Tax_Id=10090 Gene_Symbol=Gm9825 similar to Rnps1 protein Tax_Id=10090 Gene_Symbol=Rnps1 Isoform 2 of RNA-binding protein with serine-rich domain 1 Tax_Id=10090 Gene_Symbol=Rnps1 Isoform 1 of RNA-binding protein with serine-rich domain 1

1 7.586719 3.86 91.3 1 K.GYAYVEFENPDEAEK.ATax_Id=10090 Gene_Symbol=Bdh1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Bdh1 3-hydroxybutyrate dehydrogenase, type 1 precursor Tax_Id=10090 Gene_Symbol=Bdh1 29 kDa protein

1 5.661453 4.14 86.4 1 R.TIQLNVCNSEEVEK.ATax_Id=10090 Gene_Symbol=Rpl5 Ribosomal protein L5

22 5.021102 4.25 61.8 1 R.YLMEEDEDAYKK.QTax_Id=10090 Gene_Symbol=Hmgcs1 Putative uncharacterized protein

1 6.056027 4.14 100 2 R.LEVGTETIIDK.S

Tax_Id=10090 Gene_Symbol=Spnb3 Putative uncharacterized protein 1 4.158044 4.25 61 1 R.FQIQDISVETEDNKEK.K1 6.381642 3.8 87.5 1 K.LLDPEDVNVDQPDEK.S1 8.174205 4.03 53.5 1 R.EKEVEAIQAQAQALAQEDQSAGEVER.T5 6.561984 4.12 47.3 1 R.DAAEAEAWMGEQELHMMGQEK.A1 7.622946 3.86 81.5 1 K.DSLNEAWADLLELLDTR.G

Tax_Id=10090 Gene_Symbol=Fn1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Fn1 Putative uncharacterized protein

1 8.357416 4.25 74.1 3 R.GFNCESKPEPEETCFDK.Y1 9.005938 4.72 74.1 1 R.QDGHLWCSTTSNYEQDQK.Y1 7.149082 4.72 76.1 1 R.QDGHLWCSTTSNYEQDQK.Y

39 4.586426 3.64 31.3 1 R.VEYELSEEGDEPQYLDLPSTATSVNIPDLLPGR.K1 7.999936 4.25 51.5 2 K.DDKESAPISDTVVPAVPPPTDLR.F

Tax_Id=10090 Gene_Symbol=Myo18a Isoform 4 of Myosin-XVIIIa 1 5.426135 3.86 100 1 R.AVEELLESLDLEK.S1 6.860967 3.95 43.6 1 R.ISELTSELTDERNTGESASQLLDAETAER.L1 7.883195 3.96 88.9 2 R.NTGESASQLLDAETAER.L1 6.858555 4.12 50 1 K.VVSLEAELQDISSQESKDEASLAK.V1 5.900329 3.8 95 1 R.LEEDQEDMNELMK.K

Tax_Id=10090 Gene_Symbol=Eif2ak3 Eukaryotic translation initiation factor 2-alpha kinase 3 3 4.075363 3.8 43.8 1 R.VPAVATAEVTVEDAEALPAAAGEPESR.A1 5.596072 3.95 73.1 2 R.RWDSDEMEEEEDILLLQR.T

Tax_Id=10090 Gene_Symbol=Uba1 Ubiquitin-like modifier-activating enzyme 1 1 7.020474 3.96 82.8 1 R.NEEDATELVGLAQAVNAR.S1 6.153935 4.42 50.8 1 K.IHVSDQELQSANASVDDSRLEELK.A

Tax_Id=10090 Gene_Symbol=Eps8l2 Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 2 Tax_Id=10090 Gene_Symbol=Eps8l2 Isoform 2 of Epidermal growth factor receptor kinase substrate 8-like protein 2

1 7.632532 4.25 50.7 2 R.LLDVESQEELENFPLPTVQHSQTVLNQLR.YTax_Id=10090 Gene_Symbol=Ivns1abp Isoform 1 of Influenza virus NS1A-binding protein homolog

40 4.043106 4.03 35.8 1 R.SIWENGDSLEELMEEVQTLYYSADHK.LTax_Id=10090 Gene_Symbol=Acadvl Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Acadvl Acyl-Coenzyme A dehydrogenase, very long chain

1 6.675123 4.19 47.8 1 R.FFEEVNDPAKNDALEKVEDDTLQGLK.ETax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5;LOC100048744;LOC100048662 UDP glycosyltransferase 1 family polypeptide A13 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 23 kDa protein Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 23 kDa protein Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 18 kDa protein

1 9.64318 3.96 83.3 1 R.GAGVTLNVLEMTADDLENALK.TTax_Id=10090 Gene_Symbol=Cat Catalase Tax_Id=10090 Gene_Symbol=Cat catalase Tax_Id=10090 Gene_Symbol=Cat Catalase, isoform CRA_a

1 6.168646 4.58 53.2 1 R.GPLLVQDVVFTDEMAHFDRER.ITax_Id=10090 Gene_Symbol=Kpna4 Importin subunit alpha-4

1 7.661946 3.8 83.3 1 K.MAEDQAETIANLIEECGGLEK.ITax_Id=10090 Gene_Symbol=Tufm Isoform 1 of Elongation factor Tu, mitochondrial Tax_Id=10090 Gene_Symbol=- hypothetical protein Tax_Id=10090 Gene_Symbol=Tufm Isoform 2 of Elongation factor Tu, mitochondrial

1 8.414626 3.8 92.9 1 K.ADAVQDSEMVELVELEIR.E

1 4.352605 3.8 57.4 1 K.ADAVQDSEMVELVELEIR.ETax_Id=10090 Gene_Symbol=Fkbp8 Isoform 1 of Peptidyl-prolyl cis-trans isomerase FKBP8 Tax_Id=10090 Gene_Symbol=Fkbp8 Isoform 2 of Peptidyl-prolyl cis-trans isomerase FKBP8

1 7.705672 3.86 75 1 K.TAEDGPDLEMLSGQER.VTax_Id=10090 Gene_Symbol=Stoml2 Stomatin-like protein 2 Tax_Id=10090 Gene_Symbol=Stoml2 Stomatin (Epb7.2)-like 2

1 7.284089 3.96 95.5 2 R.DVQATDTSIEELGR.VTax_Id=10090 Gene_Symbol=Ptgr1 Prostaglandin reductase 1

1 6.507394 4.72 71.4 1 K.VQCHEYVTEGFEK.MTax_Id=10090 Gene_Symbol=Flna Isoform 2 of Filamin-A Tax_Id=10090 Gene_Symbol=Flnc Isoform 2 of Filamin-C Tax_Id=10090 Gene_Symbol=Flnc Isoform 1 of Filamin-C

1 4.659928 4.72 93.8 1 K.DLAEDAPWKK.ITax_Id=10090 Gene_Symbol=Nedd4 E3 ubiquitin-protein ligase NEDD4

1 7.830691 3.96 75.9 2 R.DDFLGQVDVPLYPLPTENPR.M1 6.194222 3.86 73.9 2 R.LDLPPYESFDELWDK.L

Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 Tax_Id=10090 Gene_Symbol=Exosc10 exosome component 10 Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10 Tax_Id=10090 Gene_Symbol=Exosc10 Exosome component 10

2 5.994635 4.25 50 2 R.AVGETPCHLVSSLDELVELNEK.L1 5.358323 4.72 83.3 2 R.DDTHYLLYIYDR.M

Tax_Id=10090 Gene_Symbol=Las1l Isoform 1 of Protein LAS1 homolog Tax_Id=10090 Gene_Symbol=Las1l Isoform 2 of Protein LAS1 homolog

1 6.423802 4.03 44.3 1 R.LPGQTEDPAELMLDNYDTMYLLDQPVIEHR.LTax_Id=10090 Gene_Symbol=Ppp2r1a Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1 9.11165 4.58 57.1 3 K.DNTIEHLLPLFLAQLKDECPEVR.LTax_Id=10090 Gene_Symbol=Riok1 Serine/threonine-protein kinase RIO1

1 9.456476 3.8 69 2 R.ELFDFVTDPSITADNMDAYLEK.ATax_Id=10090 Gene_Symbol=Aldh6a1 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

1 9.702935 3.8 86.7 2 K.EEIFGPVLVVLETETLDEAIK.I1 5.909332 3.8 46.2 2 K.EEIFGPVLVVLETETLDEAIK.I

Tax_Id=10090 Gene_Symbol=Dpys Dihydropyrimidinase 1 8.956351 3.86 70 2 R.IVNDDFSQVADVLVEDGVVR.A

Tax_Id=10090 Gene_Symbol=Sept7 cell division cycle 10 homolog Tax_Id=10090 Gene_Symbol=Sept7 Septin-7

1 9.361938 4.03 92.6 1 K.IYEFPETDDEEENKLVK.KTax_Id=10090 Gene_Symbol=Acot10 Acyl-coenzyme A thioesterase 10, mitochondrial Tax_Id=10090 Gene_Symbol=Acot9 Acyl-coenzyme A thioesterase 9, mitochondrial

1 7.965132 3.96 63 1 R.DSYIEVLLPLGTDPELR.DTax_Id=10090 Gene_Symbol=Lgmn Legumain

1 6.652093 3.96 82.1 2 K.DYTGEDVTPENFLAVLR.GTax_Id=10090 Gene_Symbol=Fam82a1 Regulator of microtubule dynamics protein 2

2 4.638225 4.25 64.1 1 K.LNELLTNMEELKEEIR.FTax_Id=10090 Gene_Symbol=Hsd17b2 Estradiol 17-beta-dehydrogenase 2

1 8.067639 4.72 95.8 1 K.DIQENYGQDYVHTQK.LTax_Id=10090 Gene_Symbol=H2-L H-2 class I histocompatibility antigen, L-D alpha chain Tax_Id=10090 Gene_Symbol=Gm8810 MHC class I antigen (Fragment) Tax_Id=10090 Gene_Symbol=H2-gs10 H2-gs10 protein Tax_Id=10090 Gene_Symbol=H2-Q10 40 kDa protein Tax_Id=10090 Gene_Symbol=Gm8909 hypothetical protein LOC667977 Tax_Id=10090 Gene_Symbol=H2-L H2-D1 protein (Fragment) Tax_Id=10090 Gene_Symbol=H2-D1 MHC class I L-q alpha-chain gene (H2 haplotype), exons 1-3 (Fragment) Tax_Id=10090 Gene_Symbol=H2-Q1 14 kDa protein Tax_Id=10090 Gene_Symbol=H2-Q2 H2-D1 protein (Fragment) Tax_Id=10090 Gene_Symbol=H2-Q2 H2-D1 protein (Fragment) Tax_Id=10090 Gene_Symbol=Gm8909 MHC classIb T5 Tax_Id=10090 Gene_Symbol=H2-Bl Truncated MHC class I antigen splice variant Bl.2 Tax_Id=10090 Gene_Symbol=H2-D1 MHC class I D-q alpha-chain (H2 haplotype), exons 1-3 (Fragment) Tax_Id=10090 Gene_Symbol=LOC634869 similar to major histocompability complex Q1b Tax_Id=10090 Gene_Symbol=H2-L H-2D cell surface glycoprotein (Fragment) Tax_Id=10090 Gene_Symbol=H2-L H-2D cell surface glycoprotein (Fragment) Tax_Id=10090 Gene_Symbol=H2-D1 H-2 class I histocompatibility antigen, D-B alpha chain Tax_Id=10090 Gene_Symbol=H2-Q1 MCG68121, isoform CRA_b Tax_Id=10090 Gene_Symbol=H2-Q10 41 kDa protein Tax_Id=10090 Gene_Symbol=LOC547349 MHC class I antigen Tax_Id=10090 Gene_Symbol=H2-gs10 MHC class I like protein GS10 Tax_Id=10090 Gene_Symbol=H2-L H-2D cell surface glycoprotein (Fragment) Tax_Id=10090 Gene_Symbol=H2-gs10 40 kDa protein Tax_Id=10090 Gene_Symbol=H2-Q10 H2-Q10 protein (Fragment) Tax_Id=10090 Gene_Symbol=H2-Q2;H2-Q1 Class Ib major histocompatibility complex Tax_Id=10090 Gene_Symbol=H2-Q10 H-2 class I histocompatibility antigen, Q10 alpha chain Tax_Id=10090 Gene_Symbol=H2-D1 H-2D cell surface glycoprotein Tax_Id=10090 Gene_Symbol=H2-Bl Major histocompatibility complex class I b

1 8.061541 3.96 86.4 1 Q.APWMEQEGPEYWER.I1 7.088612 3.96 90 1 P.WMEQEGPEYWER.I

Tax_Id=10090 Gene_Symbol=Krt42 Putative uncharacterized protein 1 6.362315 4.14 92.9 1 K.DAEEWFFTK.T

Tax_Id=10090 Gene_Symbol=Sf3b1 Splicing factor 3B subunit 1 1 7.038622 4.12 75 1 K.LLVDVDESTLSPEEQKER.K1 6.379345 4.57 81 1 R.IVDDLKDEAEQYRK.M1 6.778873 3.96 58.6 2 K.DYIYAVTPLLEDALMDR.D

Tax_Id=10090 Gene_Symbol=Sf3b3 Isoform 1 of Splicing factor 3B subunit 3 Tax_Id=10090 Gene_Symbol=Sf3b3 Isoform 2 of Splicing factor 3B subunit 3

1 7.978625 3.86 90.9 1 K.ITLETDEDMVTEIR.L1 8.142489 3.86 76.9 2 R.LPPNTNDEVDEDPTGNK.A1 7.372432 4.4 87 1 K.NVSEELDRTPPEVSK.K

Tax_Id=10090 Gene_Symbol=Acsl5 Long-chain-fatty-acid--CoA ligase 5 2 5.993643 4.4 38.6 1 K.FLEPIFQPTSDDVTISYLPLAHMFER.L

Tax_Id=10090 Gene_Symbol=Rhot2 70 kDa protein Tax_Id=10090 Gene_Symbol=Rhot2 Mitochondrial Rho GTPase 2

5 6.05381 4.2 40 1 K.VPTHIVDYSEAEQTEEELQEEIHK.ATax_Id=10090 Gene_Symbol=Krt1 Keratin, type II cytoskeletal 1

1 5.166164 6.56 95 1 R.FLEQQNQVLQTK.W1 6.95813 4.46 88.9 2 R.TNAENEFVTIK.K1 7.30665 6.56 94.7 1 R.TNAENEFVTIKK.D

Tax_Id=10090 Gene_Symbol=Krt77 Keratin, type II cytoskeletal 1b 1 5.166164 6.56 95 1 R.FLEQQNQVLQTK.W1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T

Tax_Id=10090 Gene_Symbol=Eif2b4 Isoform 1 of Translation initiation factor eIF-2B subunit delta Tax_Id=10090 Gene_Symbol=Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta isoform 2 Tax_Id=10090 Gene_Symbol=Eif2b4 62 kDa protein Tax_Id=10090 Gene_Symbol=Eif2b4 Isoform 2 of Translation initiation factor eIF-2B subunit delta

1 7.540856 3.8 75.9 1 R.VQTDAFVSNELDDPDDLQCK.RTax_Id=10090 Gene_Symbol=Hpd 4-hydroxyphenylpyruvate dioxygenase Tax_Id=10090 Gene_Symbol=Hpd 18 kDa protein

1 6.581592 4.25 83.3 1 K.DIAFEVEDCDHIVQK.ATax_Id=10090 Gene_Symbol=Hsd3b3 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 3 Tax_Id=10090 Gene_Symbol=Hsd3b2 3 beta-hydroxysteroid dehydrogenase 2 Tax_Id=10090 Gene_Symbol=Hsd3b6 3 beta-hydroxysteroid dehydrogenase 6 Tax_Id=10090 Gene_Symbol=Gm4450 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 3 Tax_Id=10090 Gene_Symbol=Gm4450 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 1 Tax_Id=10090 Gene_Symbol=Gm10681 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 3 Tax_Id=10090 Gene_Symbol=Hsd3b3 3 beta-hydroxysteroid dehydrogenase 3 isoform 2 Tax_Id=10090 Gene_Symbol=Hsd3b6 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 6 Tax_Id=10090 Gene_Symbol=Hsd3b2 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 2 Tax_Id=10090 Gene_Symbol=Hsd3b4;Gm10681 3 beta-hydroxysteroid dehydrogenase type 4

1 8.692047 3.96 100 1 R.DLGYEPLVSWEEAK.QTax_Id=10090 Gene_Symbol=Hsd3b5 3 beta-hydroxysteroid dehydrogenase type 5

1 7.3726 4.14 85 2 R.DLGYQPLVSWEEAK.QTax_Id=10090 Gene_Symbol=1810022C23Rik MCG120270, isoform CRA_a Tax_Id=10090 Gene_Symbol=Peci Isoform 1 of Peroxisomal 3,2-trans-enoyl-CoA isomerase Tax_Id=10090 Gene_Symbol=Peci Isoform 2 of Peroxisomal 3,2-trans-enoyl-CoA isomerase

1 5.517255 4.14 90 1 K.DILVTSEDGITK.ITax_Id=10090 Gene_Symbol=Myh10 Myosin, heavy polypeptide 10, non-muscle Tax_Id=10090 Gene_Symbol=Myh10 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Myh10 Myosin-10

1 8.519996 4.4 72.4 1 K.VEDMAELTCLNEASVLHNLK.D1 5.814803 4.72 100 1 R.AGVLAHLEEER.D3 5.525894 3.89 40 1 R.DLSEELEALKTELEDTLDTTAAQQELR.T1 8.968273 3.69 100 6 R.TQLEELEDELQATEDAK.L

Tax_Id=10090 Gene_Symbol=Hdlbp Vigilin 3 6.505232 4.03 39.4 2 R.EAQKELEALIQNLENVVEDYMLVDPK.H1 9.278583 3.8 85.7 1 K.ELEALIQNLENVVEDYMLVDPK.H2 6.049598 3.8 45 1 K.ELEALIQNLENVVEDYMLVDPK.H1 5.711717 4.25 53.6 1 K.EALEALVPVTIEVEVPFDLHR.Y

Tax_Id=10090 Gene_Symbol=Zyx Zyxin Tax_Id=10090 Gene_Symbol=Zyx Zyx protein Tax_Id=10090 Gene_Symbol=Zyx zyxin

1 7.594768 4.12 84.6 1 K.EVEELEQLTQQLMQDMEHPQR.Q

Tax_Id=10090 Gene_Symbol=Gltscr2 glioma tumor suppressor candidate region gene 2 1 10.40708 3.8 93.1 2 R.LAEEPLGLEVDQFLEDVR.L

Tax_Id=10090 Gene_Symbol=Strap 39 kDa protein Tax_Id=10090 Gene_Symbol=Strap Serine-threonine kinase receptor-associated protein

1 8.801445 3.96 100 2 K.YDYNSGEELESYK.GTax_Id=10090 Gene_Symbol=Gm6807 similar to ribosomal protein L6 isoform 1 Tax_Id=10090 Gene_Symbol=Gm6807 similar to ribosomal protein L6 isoform 2

1 7.182919 4.4 100 14 R.HQEGEIFDTEK.DTax_Id=10090 Gene_Symbol=Eef2 Elongation factor 2

1 5.596717 3.86 51.7 1 R.CELLYEGPPDDEAAMGIK.S1 5.269208 4.89 95.2 1 K.DLEEDHACIPIKK.S

Tax_Id=10090 Gene_Symbol=Hgs Hepatocyte growth factor-regulated tyrosine kinase substrate Tax_Id=10090 Gene_Symbol=Hgs HGF-regulated tyrosine kinase substrate isoform 1

1 8.516017 4.05 49.3 1 K.RDETALQEEEELQLALALSQSEAEEKER.MTax_Id=10090 Gene_Symbol=Hspa2 Heat shock-related 70 kDa protein 2 Tax_Id=10090 Gene_Symbol=Hspa2 heat shock protein 2

1 5.409415 4.46 94.7 4 K.VEIIANDQGNR.T1 5.35944 4.72 100 1 R.ARFEELNADLFR.G1 4.931673 4.72 68.6 1 R.ARFEELNADLFR.G1 6.608333 4.14 100 2 R.FEELNADLFR.G

Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1 Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1 Tax_Id=10090 Gene_Symbol=Ewsr1 RNA-binding protein EWS Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1 Tax_Id=10090 Gene_Symbol=Ewsr1 Ewing sarcoma breakpoint region 1

1 7.038168 4.72 51.6 1 R.QDHPSSMGVYGQESGGFSGPGENR.STax_Id=10090 Gene_Symbol=Ctnnd1 68 kDa protein

1 5.831264 4.4 72.4 1 R.DMDLTEVITGTLWNLSSHDSIK.MTax_Id=10090 Gene_Symbol=Ik IK cytokine Tax_Id=10090 Gene_Symbol=Ik Protein Red

1 4.186878 4.25 47.2 1 R.DGVNKDYEETELISTTANYR.ATax_Id=10090 Gene_Symbol=Dak Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

1 8.423138 4.14 71.4 1 R.AAPTEPPEAPEATAAGGVTSK.QTax_Id=10090 Gene_Symbol=Flna 56 kDa protein

1 6.812907 4.4 77.4 1 K.DAGEGLLAVQITDPEGKPK.KTax_Id=10090 Gene_Symbol=Baat Bile acid-CoA:amino acid N-acyltransferase

1 6.912971 3.86 80 1 K.VDLEYFEEGVEFLLR.HTax_Id=10090 Gene_Symbol=Aldob Fructose-bisphosphate aldolase B

1 5.200244 4.14 72.7 1 K.ETTIQGLDGLSER.CTax_Id=10090 Gene_Symbol=Tgm2 Protein-glutamine gamma-glutamyltransferase 2

1 7.269046 4.8 46 2 K.SVGRDDREDITHTYKYPEGSPEER.E1 4.166378 4.53 50.9 1 R.DDREDITHTYKYPEGSPEER.E

Tax_Id=10090 Gene_Symbol=Wdr46 WD repeat-containing protein 46 1 8.508308 3.69 86.7 1 R.AELLLAEEPGFLVGEDGEDTAK.I

Tax_Id=10090 Gene_Symbol=Elp3 Isoform 2 of Elongator complex protein 3 Tax_Id=10090 Gene_Symbol=Elp3 Isoform 1 of Elongator complex protein 3

1 5.222965 4.25 51.9 2 R.DIEQFIEFFENPAFRPDGLK.LTax_Id=10090 Gene_Symbol=Myef2 Isoform 2 of Myelin expression factor 2

Tax_Id=10090 Gene_Symbol=Myef2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Myef2 myelin basic protein expression factor 2, repressor isoform 3 Tax_Id=10090 Gene_Symbol=Myef2 Myelin basic protein expression factor 2, repressor Tax_Id=10090 Gene_Symbol=Myef2;Gm9833 Isoform 4 of Myelin expression factor 2 Tax_Id=10090 Gene_Symbol=LOC100045569 similar to Myef2 protein Tax_Id=10090 Gene_Symbol=Myef2 Isoform 1 of Myelin expression factor 2

6 4.356113 4.57 49 1 K.YDLSGRPLNIKEDPDGENAR.RTax_Id=10090 Gene_Symbol=Lap3 Isoform 1 of Cytosol aminopeptidase Tax_Id=10090 Gene_Symbol=Lap3 Isoform 2 of Cytosol aminopeptidase

1 7.275976 4.25 82.8 1 K.DKDDDLPQFTSAGESFNK.LTax_Id=10090 Gene_Symbol=Ddx6 Probable ATP-dependent RNA helicase DDX6

1 8.859517 4.25 81.5 1 K.SLYVAEYHSEPAEDEKP.-Tax_Id=10090 Gene_Symbol=Dctn2 Dynactin subunit 2

1 5.776341 4.4 95.5 1 R.LLHEVQELTTEVEK.ITax_Id=10090 Gene_Symbol=Oplah 5-oxoprolinase

1 6.49841 4.12 39 4 R.DLLHIGTQARPDLFDLAVPMPEVLYEEVVEVDER.V1 5.9722 4.14 93.8 2 R.ITDPEILESR.Y

Tax_Id=10090 Gene_Symbol=Lig3 Isoform Alpha of DNA ligase 3 Tax_Id=10090 Gene_Symbol=Lig3 113 kDa protein Tax_Id=10090 Gene_Symbol=Lig3 DNA ligase (ATP) 3 Tax_Id=10090 Gene_Symbol=Lig3 DNA ligase Tax_Id=10090 Gene_Symbol=Lig3 Isoform Beta of DNA ligase 3

5 5.855938 4.12 34.8 1 K.DKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCK.GTax_Id=10090 Gene_Symbol=Zbtb10 zinc finger and BTB domain containing 10

49 4.630225 4.12 34.2 1 R.SGGDGGDEAEGSGVGAGEGETVQHFPLAR.PTax_Id=10090 Gene_Symbol=Wdr26 WD repeat-containing protein 26 Tax_Id=10090 Gene_Symbol=LOC100045629;Wdr26 WD repeat domain 26 Tax_Id=10090 Gene_Symbol=LOC100045629 similar to myocardial ischemic preconditioning upregulated protein 2 isoform 1

1 6.042882 3.86 65.4 1 R.IWGPAPFIDHQNIEEECSSMDS.-Tax_Id=10090 Gene_Symbol=Dlat Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1 9.510985 4.4 82.1 1 R.DVPVGSIICITVEKPQDIEAFK.NTax_Id=10090 Gene_Symbol=Chdh Choline dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Chdh Putative uncharacterized protein

1 5.329198 4.58 50 1 R.DHPVIHPNYLSTETDVEDFR.QTax_Id=10090 Gene_Symbol=Nt5c2 Cytosolic purine 5'-nucleotidase Tax_Id=10090 Gene_Symbol=Nt5c2 5'-nucleotidase, cytosolic II isoform 1 Tax_Id=10090 Gene_Symbol=Nt5c2 5'-nucleotidase, cytosolic II isoform 2

1 9.690022 3.96 85.2 1 K.SSLFEELQSLDIFLAELYK.HTax_Id=10090 Gene_Symbol=Sptlc2 Serine palmitoyltransferase 2

1 9.264419 3.69 70.4 2 R.LVPLLDRPFDETTYEETED.-Tax_Id=10090 Gene_Symbol=Ugt2b37 MCG131369

1 6.727598 3.96 69 1 R.SDVLNALEEVIENPFYK.K1 5.633651 3.96 66 1 R.SDVLNALEEVIENPFYK.K1 8.268647 4.4 82.8 1 R.SDVLNALEEVIENPFYKK.N

Tax_Id=10090 Gene_Symbol=Dtx3l 53 kDa protein Tax_Id=10090 Gene_Symbol=Dtx3l Isoform 2 of E3 ubiquitin-protein ligase DTX3L Tax_Id=10090 Gene_Symbol=Dtx3l Isoform 1 of E3 ubiquitin-protein ligase DTX3L

1 6.216233 3.86 62.5 1 K.LLEPELLQEISEIEQK.F

Tax_Id=10090 Gene_Symbol=Gdi2 Isoform 1 of Rab GDP dissociation inhibitor beta Tax_Id=10090 Gene_Symbol=Gdi2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Gdi2 Isoform 2 of Rab GDP dissociation inhibitor beta

1 7.516819 3.96 83.3 1 R.TDDYLDQPCCETINR.ITax_Id=10090 Gene_Symbol=LOC100048642 similar to Snx5 protein

1 5.662869 3.86 95.5 1 K.FNADEFEDMVAEK.QTax_Id=10090 Gene_Symbol=Eno1 Enolase Tax_Id=10090 Gene_Symbol=Eno1 Enolase 1, alpha non-neuron Tax_Id=10090 Gene_Symbol=LOC100047882 similar to enolase 1, alpha non-neuron

1 6.883618 4.14 100 3 K.LMIEMDGTENK.STax_Id=10090 Gene_Symbol=Purb Transcriptional activator protein Pur-beta

1 6.656418 4.4 94.4 1 R.YADEMKEIQER.Q2 6.678989 4.4 63.6 1 R.YADEMKEIQER.Q

Tax_Id=10090 Gene_Symbol=Letm1 LETM1 and EF-hand domain-containing protein 1, mitochondrial 1 4.868755 4.05 53.4 1 K.EKEELELLKEDVQDYSEDLQEIK.K1 7.317544 4.23 51.5 2 K.EKEELELLKEDVQDYSEDLQEIKK.E1 5.401685 4.23 43 1 K.EKEELELLKEDVQDYSEDLQEIKK.E

Tax_Id=10090 Gene_Symbol=Tmpo Isoform Alpha of Lamina-associated polypeptide 2, isoforms alpha/zeta Tax_Id=10090 Gene_Symbol=Tmpo Isoform Zeta of Lamina-associated polypeptide 2, isoforms alpha/zeta Tax_Id=10090 Gene_Symbol=Tmpo Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma Tax_Id=10090 Gene_Symbol=Tmpo Isoform Delta of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma Tax_Id=10090 Gene_Symbol=Tmpo Isoform Epsilon of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma Tax_Id=10090 Gene_Symbol=Tmpo Putative uncharacterized protein (Fragment) Tax_Id=10090 Gene_Symbol=Tmpo Isoform Beta of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

1 8.554949 3.89 89.3 1 R.LEDKDDLDVTELSNEELLDQLVR.Y1 5.672938 3.89 50 1 R.LEDKDDLDVTELSNEELLDQLVR.Y

Tax_Id=10090 Gene_Symbol=Fxr2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Fxr2 Fragile X mental retardation syndrome-related protein 2 Tax_Id=10090 Gene_Symbol=Fxr2 Putative uncharacterized protein (Fragment)

6 5.49468 4.12 44.8 1 R.LPPPADYNKEITEGDEVEVYSR.A1 7.11386 3.86 100 1 K.EITEGDEVEVYSR.A

Tax_Id=10090 Gene_Symbol=Ddx52 Probable ATP-dependent RNA helicase DDX52 1 9.580374 3.96 58.6 2 R.NSAVETVEQELLFVGSETGK.L

Tax_Id=10090 Gene_Symbol=Krt5 Keratin, type II cytoskeletal 5 Tax_Id=10090 Gene_Symbol=Krt5 60 kDa protein

1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T2 5.766051 4.46 83.3 1 K.AQYEDIANR.S

Tax_Id=10090 Gene_Symbol=Atl3 Isoform 1 of Atlastin-3 Tax_Id=10090 Gene_Symbol=Atl3 atlastin GTPase 3 isoform 1

1 7.414141 4.12 56 1 R.YQQELEEEIKELYENFCK.HTax_Id=10090 Gene_Symbol=Cyp2a12 MCG133379, isoform CRA_a Tax_Id=10090 Gene_Symbol=Cyp2a12 Cytochrome P450 2A12

1 6.312462 4.4 84.6 1 R.KLEDINESPTPEGFTR.ITax_Id=10090 Gene_Symbol=Pacsin2 Protein kinase C and casein kinase substrate in neurons protein 2

1 7.754213 4.25 72 1 R.ALYDYEGQEHDELSFK.ATax_Id=10090 Gene_Symbol=Grsf1 G-rich sequence factor 1 Tax_Id=10090 Gene_Symbol=Grsf1 G-rich RNA sequence binding factor 1 isoform 2

1 7.915232 4.25 84.6 1 R.RGDALIEMESEQDVQK.ATax_Id=10090 Gene_Symbol=Gm5620 similar to Tubulin, alpha 3c isoform 1 Tax_Id=10090 Gene_Symbol=Gm5620 similar to Tubulin, alpha 3c isoform 3

1 6.601391 3.96 95.7 1 R.AVFVDLEPTVIDEVR.TTax_Id=10090 Gene_Symbol=Rnh1 Ribonuclease inhibitor Tax_Id=10090 Gene_Symbol=Rnh1 ribonuclease inhibitor isoform b

1 7.46859 4.4 76.9 1 K.ELSLASNELKDEGAR.LTax_Id=10090 Gene_Symbol=Krt2 Keratin (Fragment) Tax_Id=10090 Gene_Symbol=Krt2 71 kDa protein Tax_Id=10090 Gene_Symbol=Krt2 Keratin, type II cytoskeletal 2 epidermal

1 5.674906 4.46 92.9 1 R.DYQELMNTK.LTax_Id=10090 Gene_Symbol=Flnb Filamin-B

1 4.659928 4.72 93.8 1 K.DLAEDAPWKK.I1 5.259384 4.03 42.6 1 K.FTVDTISAGQGDVMVFVEDPEGNKEEAR.V1 6.543955 4.14 88.2 1 K.NSVELLVEDR.G1 6.860137 4.4 65.6 1 R.DAGEGLLAVQITDQEGKPQR.A1 6.42786 3.86 90.9 1 K.VDIQTEDLEDGTCK.V

Tax_Id=10090 Gene_Symbol=Myo6 Myosin-VI Tax_Id=10090 Gene_Symbol=Myo6 146 kDa protein

1 9.084539 3.86 78.6 1 K.SAPSLEYCAELLGLDQDDLR.V1 10.49902 3.86 73.3 1 R.IAQNESELISDEAQGDMALR.R

Tax_Id=10090 Gene_Symbol=Uso1 Isoform 1 of General vesicular transport factor p115 Tax_Id=10090 Gene_Symbol=Uso1 Isoform 2 of General vesicular transport factor p115 Tax_Id=10090 Gene_Symbol=Uso1 Isoform 3 of General vesicular transport factor p115

1 8.393962 3.56 47.4 1 R.SDSEIIAYALDTLYNIISNDEEEELEENSTR.QTax_Id=10090 Gene_Symbol=Mttp Isoform 1 of Microsomal triglyceride transfer protein large subunit Tax_Id=10090 Gene_Symbol=Mttp Isoform 2 of Microsomal triglyceride transfer protein large subunit

1 4.735926 3.8 43.2 1 K.EVLPQLVDAVTSAQTPDSLEAILDFLDFK.STax_Id=10090 Gene_Symbol=Slc4a1ap solute carrier family 4 (anion exchanger), member 1, adaptor protein Tax_Id=10090 Gene_Symbol=Slc4a1ap Slc4a1ap protein Tax_Id=10090 Gene_Symbol=Slc4a1ap 83 kDa protein Tax_Id=10090 Gene_Symbol=Slc4a1ap Kanadaptin

1 5.426077 4.12 55.7 2 R.LFILQGPEEDREAESELTVTQLK.ETax_Id=10090 Gene_Symbol=Dll4 delta-like 4 precursor

1 4.850633 8.59 50 1 R.CTSNPCANGGQCQNRGPSRT(79.9663)CR.CTax_Id=10090 Gene_Symbol=Papss2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Tax_Id=10090 Gene_Symbol=Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1 8.22041 4.25 74.1 1 K.GFTGIDSDYEKPETPECVLK.TTax_Id=10090 Gene_Symbol=Cct4 T-complex protein 1 subunit delta

1 7.98834 3.96 70.4 1 K.TDMDNQIVVSDYAQMDR.VTax_Id=10090 Gene_Symbol=Slc7a11 Cystine/glutamate transporter

1 5.257866 3.96 75 1 R.TLQIILEVVPEDSKEL.-Tax_Id=10090 Gene_Symbol=Foxo4 Forkhead box protein O4 Tax_Id=10090 Gene_Symbol=Foxo4 Forkhead box O4 Tax_Id=10090 Gene_Symbol=Foxo3 Foxo3 protein (Fragment) Tax_Id=10090 Gene_Symbol=Foxo3 Forkhead box O3a

1 6.083241 6.56 94.1 4 K.DKGDSNSSAGWK.N1 6.413917 6.56 100 7 K.DKGDSNSSAGWK.N

1 6.32866 8.8 92.3 2 K.DKGDSNSSAGWKNSIR.H1 5.828032 8.8 77.8 2 K.DKGDSNSSAGWKNS(79.9663)IR.H

Tax_Id=10090 Gene_Symbol=Utp3 Isoform 1 of Something about silencing protein 10 Tax_Id=10090 Gene_Symbol=Utp3 Isoform 2 of Something about silencing protein 10

1 6.522038 3.86 91.3 2 K.ESPELLELIEDLQAK.LTax_Id=10090 Gene_Symbol=Ddost Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Tax_Id=10090 Gene_Symbol=Ddost Putative uncharacterized protein

1 6.526918 3.8 86.4 1 R.ELGSECGIEFDEEK.TTax_Id=10090 Gene_Symbol=H2-K1 42 kDa protein Tax_Id=10090 Gene_Symbol=LOC676708 similar to class I (Qa) Q2k antigen Tax_Id=10090 Gene_Symbol=Gm8810 MHC class I antigen (Fragment) Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t 33 kDa protein Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t 23 kDa protein Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t 37 kDa protein Tax_Id=10090 Gene_Symbol=H2-K1 H-2 class I histocompatibility antigen, K-B alpha chain Tax_Id=10090 Gene_Symbol=H2-Q2 Class I (Qa) Q2k antigen Tax_Id=10090 Gene_Symbol=H2-K1 MHC class Ia H2-K antigen (Fragment) Tax_Id=10090 Gene_Symbol=H2-K1 mRNA Tax_Id=10090 Gene_Symbol=H2-Q7 40 kDa protein Tax_Id=10090 Gene_Symbol=H2-Q9 H-2 class I histocompatibility antigen, Q9 alpha chain (Fragment) Tax_Id=10090 Gene_Symbol=LOC676689 MHC class I D-region cell surface antigen (Fragment) Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t similar to class Ib MHC antigen Qa-2 isoform 2 Tax_Id=10090 Gene_Symbol=H2-K1 MHC class I H2-K-b gene Tax_Id=10090 Gene_Symbol=H2-K1 40 kDa protein Tax_Id=10090 Gene_Symbol=H2-Q8 MHC class I Q8/9d cell surface antigen (Fragment) Tax_Id=10090 Gene_Symbol=C920025E04Rik C920025E04Rik protein Tax_Id=10090 Gene_Symbol=H2-Q8 H-2 class I histocompatibility antigen, Q8 alpha chain Tax_Id=10090 Gene_Symbol=H2-Q6;LOC68395;Ms10t Class Ib MHC antigen Qa-2 Tax_Id=10090 Gene_Symbol=H2-D1 MRNA, Tax_Id=10090 Gene_Symbol=H2-T23 Qa-1 Tax_Id=10090 Gene_Symbol=H2-K1 MHC class I heavy chain H2-K Tax_Id=10090 Gene_Symbol=H2-K1 MHC H-2K antigen Tax_Id=10090 Gene_Symbol=H2-Q8 histocompatibility 2, Q region locus 8 Tax_Id=10090 Gene_Symbol=H2-Q7 H-2 class I histocompatibility antigen, Q7 alpha chain Tax_Id=10090 Gene_Symbol=H2-K1 MRNA, Tax_Id=10090 Gene_Symbol=H2-D1 H-2 class I histocompatibility antigen, D-K alpha chain

1 7.088612 3.96 90 1 R.WMEQEGPEYWER.ETax_Id=10090 Gene_Symbol=Gnb2l1 Guanine nucleotide-binding protein subunit beta-2-like 1

2 5.068754 4.46 82.4 1 R.DETNYGIPQR.ATax_Id=10090 Gene_Symbol=Copa Putative uncharacterized protein

1 4.894077 4.23 30.1 1 K.SLAYLSAATHGLDEEAESLKETFDPEKETIPDIDPNAK.LTax_Id=10090 Gene_Symbol=Dhx36 Probable ATP-dependent RNA helicase DHX36

6 5.400506 4.25 33.3 1 K.FSEYFGNCPMIHIPGFTFPVVEYLLEDIIEK.ITax_Id=10090 Gene_Symbol=Rbm6 RNA binding motif protein 6 isoform b

1 8.005361 3.95 42.9 2 K.LSGGEQQSSDAGLFKEEGDLDFLGQQDTDYR.STax_Id=10090 Gene_Symbol=Pygl Glycogen phosphorylase, liver form Tax_Id=10090 Gene_Symbol=Pygl Phosphorylase Tax_Id=10090 Gene_Symbol=Pygl liver glycogen phosphorylase

1 6.383602 3.86 90 1 R.EGWQVEEADDWLR.H1 5.941156 4.4 85.7 2 K.DFSELEPDKFQNK.T

Tax_Id=10090 Gene_Symbol=Matr3 Matrin-3 17 6.672035 4.42 34.3 2 R.DLDELSRYPEDKITPENLPQILLQLK.R

Tax_Id=10090 Gene_Symbol=Hook2 Protein Hook homolog 2 Tax_Id=10090 Gene_Symbol=Hook2 hook homolog 2 isoform 2 Tax_Id=10090 Gene_Symbol=Hook2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Hook2 hook homolog 2 isoform 1

45 4.258261 4.4 41.1 1 R.IMTLEESVQHVVMEAIQELMTK.DTax_Id=10090 Gene_Symbol=Psmd11 26S proteasome non-ATPase regulatory subunit 11

1 5.454784 3.86 95.2 2 R.DIQENDEEAVQVK.ETax_Id=10090 Gene_Symbol=Gm13050 similar to Eukaryotic translation elongation factor 2

1 5.269208 4.89 95.2 1 K.DLEEDHACIPIKK.STax_Id=10090 Gene_Symbol=Gm5803 predicted gene 5803

1 6.131201 4.14 100 1 K.IEVIEIMTDR.GTax_Id=10090 Gene_Symbol=Cep170 Isoform 1 of Centrosomal protein of 170 kDa

1 6.603322 4.42 40 1 R.LGEASDSELADADKASVASEVSTTSSTSKPPTGR.R1 6.731749 3.8 75 1 R.FNPDGEEEDVTVHE.-

Tax_Id=10090 Gene_Symbol=Ipo7 Importin-7 1 5.390671 3.96 90.9 2 R.ETENDDLTNVIQK.M1 10.1618 3.8 89.3 1 Y.STIIDDEDNPVDEYQIFK.A

Tax_Id=10090 Gene_Symbol=Sec24c Sec24 related gene family, member C isoform 1 Tax_Id=10090 Gene_Symbol=Sec24c Sec24 related gene family, member C isoform 2

1 7.003972 3.96 43.8 2 K.SSLAQPQMMVVSDVADMFVPLLDGFLVNVSESR.ATax_Id=10090 Gene_Symbol=Kif5b Kinesin-1 heavy chain Tax_Id=10090 Gene_Symbol=Kif5b kinesin family member 5B

1 8.150111 4.19 42.5 1 R.LQAENDASKEEVKEVLQALEELAVNYDQK.STax_Id=10090 Gene_Symbol=Ptcd1 Pentatricopeptide repeat-containing protein 1 Tax_Id=10090 Gene_Symbol=Ptcd1 pentatricopeptide repeat domain 1 Tax_Id=10090 Gene_Symbol=Ptcd1 Putative uncharacterized protein

1 6.233028 3.86 54.8 1 K.LSTVAPQEEAEEESFGSLSGK.FTax_Id=10090 Gene_Symbol=Parn Poly(A)-specific ribonuclease PARN

14 5.045547 4.42 48 1 K.FIDQVIEKIEDFLQSEEKR.STax_Id=10090 Gene_Symbol=Lcp1 Plastin-2 Tax_Id=10090 Gene_Symbol=Lcp1 13 kDa protein Tax_Id=10090 Gene_Symbol=Lcp1 8 kDa protein Tax_Id=10090 Gene_Symbol=Lcp1 11 kDa protein Tax_Id=10090 Gene_Symbol=Lcp1 12 kDa protein

30 7.009795 3.96 39.3 1 K.VDTDGNGYISCNELNDLFK.ATax_Id=10090 Gene_Symbol=Acbd3 Golgi resident protein GCP60

1 7.999048 3.86 91.7 1 K.VLEPEAAEEALENGPK.DTax_Id=10090 Gene_Symbol=Sf3a3 Splicing factor 3A subunit 3

1 8.334682 3.96 79.2 2 R.YLEMLLEYLQDYTDR.VTax_Id=10090 Gene_Symbol=Eef1a2 Elongation factor 1-alpha 2

1 6.833761 4.89 100 1 R.TIEKFEKEAAEMGK.G1 5.732416 4.89 67.6 1 R.TIEKFEKEAAEMGK.G

Tax_Id=10090 Gene_Symbol=Stau1 Staufen 4 4.286184 4.89 69.7 2 K.KEKEPEYMLLTER.G

Tax_Id=10090 Gene_Symbol=Prmt8 Protein arginine N-methyltransferase 8 Tax_Id=10090 Gene_Symbol=Prmt1 Putative uncharacterized protein

1 7.085578 4.4 94.7 1 K.GKVEEVELPVEK.VTax_Id=10090 Gene_Symbol=Actr2 Actin-related protein 2 Tax_Id=10090 Gene_Symbol=Actr2 Putative uncharacterized protein

1 6.821433 3.96 100 1 K.DLMVGDEASELR.STax_Id=10090 Gene_Symbol=- similar to Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

1 6.132137 4.46 100 2 R.DFIYVSQDPK.DTax_Id=10090 Gene_Symbol=Srrm1 Isoform 2 of Serine/arginine repetitive matrix protein 1 Tax_Id=10090 Gene_Symbol=Srrm1 Serine/arginine repetitive matrix 1 Tax_Id=10090 Gene_Symbol=Srrm1 serine/arginine repetitive matrix 1 isoform 2 Tax_Id=10090 Gene_Symbol=Srrm1 Isoform 1 of Serine/arginine repetitive matrix protein 1

33 5.649641 10.31 34.2 1 K.KPPAPPSPVQSQSPSTNWS(79.9663)PAVPAKK.ATax_Id=10090 Gene_Symbol=1810074P20Rik Isoform 1 of E3 UFM1-protein ligase 1 Tax_Id=10090 Gene_Symbol=1810074P20Rik Isoform 3 of E3 UFM1-protein ligase 1 Tax_Id=10090 Gene_Symbol=1810074P20Rik Isoform 2 of E3 UFM1-protein ligase 1

1 8.500482 4.58 55.6 1 K.HIQDAPEEFISELAEYLIKPLNK.MTax_Id=10090 Gene_Symbol=Rbm28 RNA-binding protein 28

1 6.854815 3.8 46.7 1 R.NLSFDSEEEALGEVLQQFGDLK.YTax_Id=10090 Gene_Symbol=Nxf1 Nuclear RNA export factor 1 Tax_Id=10090 Gene_Symbol=Nxf1 Nuclear RNA export factor 1 homolog (S. cerevisiae), isoform CRA_b

1 10.32557 3.69 73.3 1 R.FEEDDGDVAMNDPQDGPR.VTax_Id=10090 Gene_Symbol=Rpa1 Replication protein A 70 kDa DNA-binding subunit Tax_Id=10090 Gene_Symbol=Rpa1 replication protein A1 isoform 1

1 4.998308 4.4 50 1 K.VVTTTLWGEDADKFDGSR.QTax_Id=10090 Gene_Symbol=Msn Moesin

1 9.659101 3.86 70.4 3 K.FYPEDVSEELIQDITQR.L1 4.841049 3.86 48 1 K.FYPEDVSEELIQDITQR.L

Tax_Id=10090 Gene_Symbol=Hnrpll Isoform 1 of Heterogeneous nuclear ribonucleoprotein L-like Tax_Id=10090 Gene_Symbol=- Putative uncharacterized protein (Fragment) Tax_Id=10090 Gene_Symbol=Hnrpll Isoform 2 of Heterogeneous nuclear ribonucleoprotein L-like

1 6.836323 3.86 92.6 1 R.GLCESVVEADLVEALEK.F1 6.2453 3.86 66 1 R.GLCESVVEADLVEALEK.F

Tax_Id=10090 Gene_Symbol=Eif3d 64 kDa protein 1 5.586989 4.25 75 2 R.SDWEVKEEMDFPQLMK.M

Tax_Id=10090 Gene_Symbol=Vtn Vitronectin 1 5.823964 4.14 85.7 1 R.DSWENIFELLFWGR.S

Tax_Id=10090 Gene_Symbol=Ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Tax_Id=10090 Gene_Symbol=Ppp2r2d Protein

1 6.051218 4.4 81 1 K.DEISVDSLDFNKK.ITax_Id=10090 Gene_Symbol=Dhx9 Isoform 2 of ATP-dependent RNA helicase A

1 8.319742 3.96 58.8 2 K.AEAENNSGVESSGYGSPGPTWDR.G1 5.968409 3.86 73.1 2 R.ELDALDANDELTPLGR.I

Tax_Id=10090 Gene_Symbol=Bms1 BMS1-like, ribosome assembly protein 1 7.133889 4.25 100 1 R.HLQDLQLGDEEDAR.K1 5.46374 3.89 50.9 1 K.ILAEEEELYGDFEDLETGDVHK.G

Tax_Id=10090 Gene_Symbol=Cul1 Cullin-1 Tax_Id=10090 Gene_Symbol=Cul1 Putative uncharacterized protein

1 6.084042 4.25 46 1 K.SSKNPEEAELEDTLNQVMVVFK.YTax_Id=10090 Gene_Symbol=Dpy19l1 Isoform 1 of Protein dpy-19 homolog 1

1 8.43658 3.96 76.5 1 R.SSPPPLSGASEVDAGELGSER.TTax_Id=10090 Gene_Symbol=Srp72 signal recognition particle 72 Tax_Id=10090 Gene_Symbol=Srp72 Putative uncharacterized protein

1 8.463213 4.72 92.6 1 K.DIHTLAQLISAYSLVDPEK.ATax_Id=10090 Gene_Symbol=Trim25 E3 ubiquitin/ISG15 ligase TRIM25 Tax_Id=10090 Gene_Symbol=- Tripartite motif protein 25 Tax_Id=10090 Gene_Symbol=- Tripartite motif protein 25 Tax_Id=10090 Gene_Symbol=- Tripartite motif protein 25 Tax_Id=10090 Gene_Symbol=Trim25 Tripartite motif protein 25 Tax_Id=10090 Gene_Symbol=Trim25 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Trim25 tripartite motif protein 25

1 7.723657 4.03 85.7 2 K.AEVELIMDKGDEFEFLEK.ATax_Id=10090 Gene_Symbol=Hnrnpm Heterogeneous nuclear ribonucleoprotein M Tax_Id=10090 Gene_Symbol=Hnrnpm Heterogeneous nuclear ribonucleoprotein M

2 4.799319 4.25 60.9 1 K.EKVGEVTYVELLMDAEGK.S1 8.648477 3.96 92 1 K.VGEVTYVELLMDAEGK.S

Tax_Id=10090 Gene_Symbol=Hacl1 2-hydroxyacyl-CoA lyase 1 1 7.199457 4.14 88 1 R.DSFIVSEGANTMDIGR.T

Tax_Id=10090 Gene_Symbol=Aldh7a1 aldehyde dehydrogenase 7 family, member A1 isoform a Tax_Id=10090 Gene_Symbol=Aldh7a1 Alpha-aminoadipic semialdehyde dehydrogenase

1 7.225026 3.8 70.8 1 K.FQDEEEVFEWNNEVK.QTax_Id=10090 Gene_Symbol=Cyp2e1 Cytochrome P450 2E1

1 5.50088 3.96 90 1 R.DVTDCLLIEMEK.E1 6.839861 4.25 77.3 2 R.DVTDCLLIEMEKEK.H

Tax_Id=10090 Gene_Symbol=Ruvbl2 RuvB-like 2 Tax_Id=10090 Gene_Symbol=Ruvbl2 24 kDa protein

1 7.216016 4.72 95.5 1 K.DKVQAGDVITIDK.Ano description

1 7.161708 3.96 94.7 1 R.ALEEANTELEVK.ITax_Id=10090 Gene_Symbol=Fn1 Fibronectin

1 8.357416 4.25 74.1 3 R.GFNCESKPEPEETCFDK.Y1 9.005938 4.72 74.1 1 R.QDGHLWCSTTSNYEQDQK.Y1 7.149082 4.72 76.1 1 R.QDGHLWCSTTSNYEQDQK.Y

39 4.586426 3.64 31.3 1 R.VEYELSEEGDEPQYLDLPSTATSVNIPDLLPGR.KTax_Id=10090 Gene_Symbol=Sardh Sarcosine dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Sardh Sarcosine dehydrogenase

1 5.197542 4.25 42.4 1 R.DILQDVLDADLSNEAFPFSTHQLVR.ATax_Id=10090 Gene_Symbol=Ddx23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

4 4.324496 4.28 43.9 1 K.ILEHMPVSNQKPDTDEAEDPEK.MTax_Id=10090 Gene_Symbol=Pes1 Pescadillo homolog 1, containing BRCT domain

1 8.178704 3.86 76.9 3 K.ISEDTYALDSESSMEK.LTax_Id=10090 Gene_Symbol=Hgd Homogentisate 1,2-dioxygenase Tax_Id=10090 Gene_Symbol=Hgd homogentisate 1,2-dioxygenase

1 4.907019 4.14 84.2 1 R.DFLIPVAWYEDR.RTax_Id=10090 Gene_Symbol=Dhx38 Putative uncharacterized protein

1 7.86529 3.69 100 1 R.LEVDEDFEEDNAAK.V

1 5.528459 4.42 74.5 1 R.EADLDHYSAVIMDEAHER.STax_Id=10090 Gene_Symbol=Supt16h FACT complex subunit SPT16

1 6.69137 3.9 58.2 1 K.NVGIFLKNEDDEEEEEEKDEAEDLLGR.GTax_Id=10090 Gene_Symbol=- 68 kDa protein Tax_Id=10090 Gene_Symbol=Slain2 Isoform 1 of SLAIN motif-containing protein 2 Tax_Id=10090 Gene_Symbol=Slain2 Isoform 2 of SLAIN motif-containing protein 2

1 7.476577 3.86 65.4 1 R.LSGWEEEEESWLYSSPK.KTax_Id=10090 Gene_Symbol=Acsf2 Acyl-CoA synthetase family member 2, mitochondrial Tax_Id=10090 Gene_Symbol=- 68 kDa protein

1 5.407648 3.96 62.5 2 R.GGENIYPAELEDFFLK.HTax_Id=10090 Gene_Symbol=Arhgef2 Isoform 3 of Rho guanine nucleotide exchange factor 2 Tax_Id=10090 Gene_Symbol=Arhgef2 Isoform 2 of Rho guanine nucleotide exchange factor 2

1 6.247036 4.25 83.3 1 K.ELLSNVDQDVHELEK.ETax_Id=10090 Gene_Symbol=Pdia3 Protein disulfide-isomerase A3

1 7.5851 3.96 100 1 K.DLLTAYYDVDYEK.Nno descriptionno description

1 6.356577 3.96 95 1 R.ALEEANADLEVK.ITax_Id=10090 Gene_Symbol=Cyp2c50 Isoform 2 of Cytochrome P450 2C50 Tax_Id=10090 Gene_Symbol=LOC100044352 similar to cytochrome P450

1 5.42104 4.72 94.4 1 K.VQEEIEHVIGK.HTax_Id=10090 Gene_Symbol=Rbbp7 Retinoblastoma binding protein 7

1 5.655731 3.86 100 1 K.EMFEDTVEER.VTax_Id=10090 Gene_Symbol=Fuk L-fucose kinase Tax_Id=10090 Gene_Symbol=Fuk MFLJ00241 protein Tax_Id=10090 Gene_Symbol=Fuk Fucokinase, isoform CRA_a

3 4.869725 4.4 40 1 R.DQPLTMVYVPDGGYSYMTTDATEFLHR.LTax_Id=10090 Gene_Symbol=Safb2 MKIAA0138 protein Tax_Id=10090 Gene_Symbol=Safb scaffold attachment factor B Tax_Id=10090 Gene_Symbol=Safb2 Scaffold attachment factor B2

1 5.102628 4.12 45.6 1 K.SEPVKEEGSELEQPFAQATSSVGPDR.KTax_Id=10090 Gene_Symbol=Ndufs1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1 9.507913 3.86 60.7 1 R.YDDIEETNYFQQASELAK.LTax_Id=10090 Gene_Symbol=Crot Peroxisomal carnitine O-octanoyltransferase

1 5.980088 3.86 65.2 1 R.DIPLPEELVFTVDEK.ITax_Id=10090 Gene_Symbol=Rpn1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1 6.472615 4.14 81 1 R.ASSFVLALEPELESR.LTax_Id=10090 Gene_Symbol=Abce1 ATP-binding cassette sub-family E member 1

1 6.703136 3.96 88 2 K.YDDPPDWQEILTYFR.GTax_Id=10090 Gene_Symbol=Dld Dihydrolipoyl dehydrogenase Tax_Id=10090 Gene_Symbol=Dld Dihydrolipoyl dehydrogenase, mitochondrial

1 6.360505 4.25 81 1 K.SEEQLKEEGIEFK.I1 5.470654 4.25 77.1 1 K.SEEQLKEEGIEFK.I

Tax_Id=10090 Gene_Symbol=Ppp2r2c Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform 1 4.158661 3.96 83.3 1 K.LFEEPEDPSNR.S

Tax_Id=10090 Gene_Symbol=Eif2s3x Eukaryotic translation initiation factor 2 subunit 3, X-linked Tax_Id=10090 Gene_Symbol=LOC100048746 similar to translation initiation factor eIF-2 gamma subunit Tax_Id=10090 Gene_Symbol=Gm2223 similar to translation initiation factor eIF-2 gamma subunit

17 4.838307 4.72 57.9 2 R.RGVTIKPTVDDD.-Tax_Id=10090 Gene_Symbol=Gm3555 similar to serine/threonine kinase 38-like

1 6.004178 4.14 100 1 R.LGLDDFESLK.VTax_Id=10090 Gene_Symbol=Elavl1 ELAV-like protein 1 Tax_Id=10090 Gene_Symbol=Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1

1 5.928083 4.14 92.3 1 K.DVEDMFSR.FTax_Id=10090 Gene_Symbol=Ogdh Isoform 4 of 2-oxoglutarate dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Ogdh Isoform 3 of 2-oxoglutarate dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Ogdh Isoform 2 of 2-oxoglutarate dehydrogenase, mitochondrial Tax_Id=10090 Gene_Symbol=Ogdh Isoform 1 of 2-oxoglutarate dehydrogenase, mitochondrial

1 5.193402 4.12 44.8 1 K.YAELLVSQGVVNQPEYEEEISKYDK.ITax_Id=10090 Gene_Symbol=Gldc Glycine dehydrogenase [decarboxylating], mitochondrial Tax_Id=10090 Gene_Symbol=Gldc Putative uncharacterized protein

1 6.009044 4.03 42.4 1 K.DVCGVLFQYPDTEGKVEDFTELVDR.ATax_Id=10090 Gene_Symbol=Gaa Lysosomal alpha-glucosidase

19 4.697831 4.25 45.5 1 R.GDTVARPLFLEFPEDPSTWSVDR.QTax_Id=10090 Gene_Symbol=Exoc1 Exocyst complex component 1 Tax_Id=10090 Gene_Symbol=Exoc1 Exocyst complex component 1 Tax_Id=10090 Gene_Symbol=LOC100047515 similar to Exocyst complex component 1 Tax_Id=10090 Gene_Symbol=Exoc1 Exocyst complex component 1

1 6.2656 3.86 57.1 1 K.QVNTLMQLLDEALTEVDQIELK.LTax_Id=10090 Gene_Symbol=LOC100047696 similar to Eukaryotic translation initiation factor 3, subunit 8

1 8.935817 3.69 90.3 2 K.SEQDQAENEGEDSAVLMER.LTax_Id=10090 Gene_Symbol=Mogs Mannosyl-oligosaccharide glucosidase

1 7.472342 4.84 48.3 1 R.HTCEQGDGVGPYGWEFHDGR.TTax_Id=10090 Gene_Symbol=Vps35 Vacuolar protein sorting-associated protein 35

1 10.43603 4.12 93.3 2 K.IREDLPNLESSEETEQINK.H1 5.346088 4.12 54 1 K.IREDLPNLESSEETEQINK.H

Tax_Id=10090 Gene_Symbol=Gbe1 1,4-alpha-glucan-branching enzyme Tax_Id=10090 Gene_Symbol=Gbe1 Putative uncharacterized protein (Fragment)

1 7.544106 4.4 72.4 2 K.FSQVLHDIGENEGGIDK.F1 5.741345 4.4 68.9 1 K.FSQVLHDIGENEGGIDK.F

Tax_Id=10090 Gene_Symbol=Yme1l1 ATP-dependent metalloprotease YME1L1 1 8.011215 4.25 84.6 2 K.GVEEAKQELQEVVEFLK.N1 5.124166 4.25 76.7 1 K.GVEEAKQELQEVVEFLK.N

Tax_Id=10090 Gene_Symbol=Larp4b Isoform 2 of La-related protein 4B Tax_Id=10090 Gene_Symbol=Larp4b Isoform 3 of La-related protein 4B Tax_Id=10090 Gene_Symbol=Larp4b Isoform 1 of La-related protein 4B

1 8.84383 3.86 76 2 R.EISESTPVEEVEALFK.GTax_Id=10090 Gene_Symbol=Lrrfip1 Isoform 2 of Leucine-rich repeat flightless-interacting protein 1 Tax_Id=10090 Gene_Symbol=Lrrfip1 Lrrfip1 protein Tax_Id=10090 Gene_Symbol=Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 isoform 3

1 6.410612 3.86 72.5 2 K.DMLLELEEQLAESQR.QTax_Id=10090 Gene_Symbol=Cyp2d11 Cytochrome P450 2D11 Tax_Id=10090 Gene_Symbol=- Cyp2d12 protein Tax_Id=10090 Gene_Symbol=Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 Tax_Id=10090 Gene_Symbol=Cyp2d12 MCG10954, isoform CRA_a Tax_Id=10090 Gene_Symbol=Cyp2d11 cytochrome P450, family 2, subfamily d, polypeptide 11

1 6.611782 4.14 95 2 R.NLTDAFLAEIEK.ATax_Id=10090 Gene_Symbol=Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22

1 6.590086 3.96 100 1 R.DLTDAFLAEVEK.ATax_Id=10090 Gene_Symbol=Usp9x Ubiquitin carboxyl-terminal hydrolase

11 5.749953 4.25 35.4 1 K.YFLPIIEMVPQFLENLTDEELKK.E1 6.511574 3.86 73.1 1 K.IELFVGGELIDPGDDR.K1 9.842909 4.12 86.2 1 R.EQHDALEFFNSLVDSLDEALK.A2 4.495232 4.12 50.9 1 R.EQHDALEFFNSLVDSLDEALK.A

Tax_Id=10090 Gene_Symbol=Rfc1 Rfc1 protein Tax_Id=10090 Gene_Symbol=Rfc1 Isoform 1 of Replication factor C subunit 1 Tax_Id=10090 Gene_Symbol=Rfc1 Isoform 2 of Replication factor C subunit 1

1 5.137098 4.12 42 1 K.GAENCLEGLTFVITGVLESIERDEAK.STax_Id=10090 Gene_Symbol=Fam120a Constitutive coactivator of PPAR-gamma-like protein 1

1 7.598871 4.72 90.5 1 R.NIHDTSDLDAIAK.D1 6.220568 3.96 90.5 1 R.EAALEAAVLNKEE.-

no description1 6.153935 4.42 50.8 1 K.IHVSDQELQSANASVDDSRLEELK.A

Tax_Id=10090 Gene_Symbol=D030074E01Rik MKIAA1012 protein (Fragment) 1 7.08291 3.8 50.7 2 R.VTGEPEMIGTEVISEFLINSEESK.V

Tax_Id=10090 Gene_Symbol=Saps3 Isoform 1 of Serine/threonine-protein phosphatase 6 regulatory subunit 3 30 4.45728 4.46 33.3 1 K.NESAIVSAIQILLTLLETR.R

Tax_Id=10090 Gene_Symbol=Rbm10 Isoform 2 of RNA-binding protein 10 1 4.960102 4.42 85.7 1 R.AHLSENELEALEKNDMEQMK.Y

Tax_Id=10090 Gene_Symbol=Ctage5 CTAGE family, member 5 isoform 1 Tax_Id=10090 Gene_Symbol=Ctage5 CTAGE family, member 5 isoform 2 Tax_Id=10090 Gene_Symbol=Ctage5 CTAGE family, member 5 isoform 3

1 7.291344 4.19 62 1 K.SKLEDEILLLEEKLEEER.ATax_Id=10090 Gene_Symbol=Ppfibp1 Isoform 2 of Liprin-beta-1 Tax_Id=10090 Gene_Symbol=Ppfibp1 Ppfibp1 protein

1 6.580382 4.14 84 1 R.DAMELPDYVLLTATAK.VTax_Id=10090 Gene_Symbol=Alb Serum albumin

1 6.605121 4.25 82.6 5 K.ECCHGDLLECADDR.ATax_Id=10090 Gene_Symbol=Fbxw8 Isoform 1 of F-box/WD repeat-containing protein 8 Tax_Id=10090 Gene_Symbol=Fbxw8 Isoform 2 of F-box/WD repeat-containing protein 8

1 6.377076 3.86 77.3 2 R.DLNELDDVPFFDVR.LTax_Id=10090 Gene_Symbol=LOC100048323 similar to RIKEN cDNA C730004C24 gene isoform 3 Tax_Id=10090 Gene_Symbol=Cyp2c69 similar to RIKEN cDNA C730004C24 gene isoform 3

1 6.362267 6.56 100 1 K.DKDFLSLIGK.VTax_Id=10090 Gene_Symbol=Bat2 Large proline-rich protein BAT2

2 5.666794 3.94 37.3 1 K.EDNLKEFDQLDQENDDGWAGAHEEVDYTEK.L1 4.862064 3.94 35.5 1 K.EDNLKEFDQLDQENDDGWAGAHEEVDYTEK.L1 7.491233 4.25 78.6 1 R.GGPPCKPPAPEDEDEAWR.Q1 5.865855 4.25 61.9 1 R.GGPPCKPPAPEDEDEAWR.Q

Tax_Id=10090 Gene_Symbol=2310057J16Rik Isoform 1 of Calmodulin-regulated spectrin-associated protein 3 Tax_Id=10090 Gene_Symbol=2310057J16Rik Nezha isoform 1 Tax_Id=10090 Gene_Symbol=2310057J16Rik Isoform 2 of Calmodulin-regulated spectrin-associated protein 3

11 5.973763 4.25 35.1 1 R.NSAQPAPESGDLPTIEEALQIIHSAEPR.LTax_Id=10090 Gene_Symbol=Ppp1r12a Isoform 1 of Protein phosphatase 1 regulatory subunit 12A

Tax_Id=10090 Gene_Symbol=Ppp1r12a Isoform 2 of Protein phosphatase 1 regulatory subunit 12A 1 11.04109 3.8 96.7 1 K.VGQTAFDVADEDILGYLEELQK.K1 5.461412 3.8 46.8 2 K.VGQTAFDVADEDILGYLEELQK.K4 4.498935 4.12 45.6 1 K.VGQTAFDVADEDILGYLEELQKK.Q

Tax_Id=10090 Gene_Symbol=Znfx1 Zinc finger, NFX1-type containing 1 Tax_Id=10090 Gene_Symbol=Znfx1 Zinc finger, NFX1-type containing 1

1 10.79542 3.86 80 2 R.VDTYTLVQAEAEGEVESYR.ATax_Id=10090 Gene_Symbol=Aco1 Cytoplasmic aconitase Tax_Id=10090 Gene_Symbol=Aco1 aconitase 1

1 6.677743 3.8 73.3 1 R.DFNDTSQDPDFTQVVELDLK.TTax_Id=10090 Gene_Symbol=Cdc5l Cell division cycle 5-related protein Tax_Id=10090 Gene_Symbol=Gm9030 similar to Cell division cycle 5-like Tax_Id=10090 Gene_Symbol=Gm9029 similar to Cell division cycle 5-like

1 5.449313 3.96 85 1 K.NDFEIVLPENAEK.E1 6.252038 4.03 66.7 1 K.NDFEIVLPENAEKELEER.E

Tax_Id=10090 Gene_Symbol=Nphp3;Acad11 Acyl-CoA dehydrogenase family member 11 Tax_Id=10090 Gene_Symbol=Nphp3 74 kDa protein

1 7.903767 4.25 57.1 1 K.NLPDSDSEECLVHGDFK.LTax_Id=10090 Gene_Symbol=Immt Isoform 1 of Mitochondrial inner membrane protein Tax_Id=10090 Gene_Symbol=Immt Isoform 3 of Mitochondrial inner membrane protein Tax_Id=10090 Gene_Symbol=Immt Isoform 5 of Mitochondrial inner membrane protein Tax_Id=10090 Gene_Symbol=Immt Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Immt Isoform 2 of Mitochondrial inner membrane protein

1 6.096116 4.25 80 1 K.VQEQELKYEFEQGLSEK.LTax_Id=10090 Gene_Symbol=Cast Isoform 2 of Calpastatin Tax_Id=10090 Gene_Symbol=Cast Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Cast Isoform 1 of Calpastatin Tax_Id=10090 Gene_Symbol=Cast Isoform 6 of Calpastatin Tax_Id=10090 Gene_Symbol=Cast Isoform 5 of Calpastatin Tax_Id=10090 Gene_Symbol=Cast Isoform 4 of Calpastatin Tax_Id=10090 Gene_Symbol=Cast Isoform 3 of Calpastatin

1 8.669147 3.86 77.8 2 K.SLSESELIGELSADFDR.STax_Id=10090 Gene_Symbol=Trim56 Tripartite motif-containing protein 56 Tax_Id=10090 Gene_Symbol=Trim56 tripartite motif-containing 56

1 6.313527 3.96 77.8 1 R.EQAASVGTQVEEAAER.ITax_Id=10090 Gene_Symbol=Krt73 Keratin, type II cytoskeletal 73 Tax_Id=10090 Gene_Symbol=Krt71 Keratin, type II cytoskeletal 71 Tax_Id=10090 Gene_Symbol=Krt74 Keratin, type II cytoskeletal 74

1 5.166164 6.56 95 1 R.FLEQQNQVLQTK.WTax_Id=10090 Gene_Symbol=- ATP synthase subunit alpha

1 7.28538 5.63 88.9 1 M.HALIIYDDLSK.QTax_Id=10090 Gene_Symbol=Znfx1 NFX1-type zinc finger-containing protein 1 Tax_Id=10090 Gene_Symbol=Znfx1 zinc finger, NFX1-type containing 1

1 10.79542 3.86 80 2 R.VDTYTLVQAEAEGEVESYR.A1 8.038834 3.8 77.8 1 R.VCQPDEVTQIFFGFEDEPDAR.F

Tax_Id=10090 Gene_Symbol=Iars Isoleucyl-tRNA synthetase, cytoplasmic Tax_Id=10090 Gene_Symbol=Iars isoleucine tRNA synthetase

1 5.131069 3.96 93.3 1 K.QESDYEILER.F

1 7.045337 4.25 69.2 1 K.EIVVIHQDPEALEDIR.STax_Id=10090 Gene_Symbol=Pcx Pyruvate carboxylase, mitochondrial Tax_Id=10090 Gene_Symbol=Pcx pyruvate carboxylase isoform 1

1 7.367883 4.4 100 2 R.VVHSYEELEENYTR.A1 6.568117 3.86 100 2 K.IAEEFEVELER.G

Tax_Id=10090 Gene_Symbol=Kdm1a Lysine-specific histone demethylase 1 Tax_Id=10090 Gene_Symbol=LOC100046934 similar to amine oxidase (flavin containing) domain 2 Tax_Id=10090 Gene_Symbol=Kdm1a Amine oxidase (Flavin containing) domain 2 Tax_Id=10090 Gene_Symbol=Kdm1a Amine oxidase (Flavin containing) domain 2

1 7.859638 4.58 71.4 1 K.HWDQDDDFEFTGSHLTVR.NTax_Id=10090 Gene_Symbol=Dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 10 Tax_Id=10090 Gene_Symbol=Dnajc10 DnaJ homolog subfamily C member 10 Tax_Id=10090 Gene_Symbol=Dnajc10 Putative uncharacterized protein (Fragment)

1 8.758454 3.8 75.9 1 R.YDFGIYDDDPEIITLER.RTax_Id=10090 Gene_Symbol=Csde1 Cold shock domain-containing protein E1 Tax_Id=10090 Gene_Symbol=Csde1 cold shock domain containing E1, RNA binding isoform 2 Tax_Id=10090 Gene_Symbol=Csde1 MKIAA0885 protein (Fragment)

1 7.354983 4.12 66.7 2 K.DKEAEDGIIAYDDCGVK.LTax_Id=10090 Gene_Symbol=Ddx27 Isoform 1 of Probable ATP-dependent RNA helicase DDX27 Tax_Id=10090 Gene_Symbol=Ddx27 MCG14602, isoform CRA_c

1 6.489085 3.96 88.5 1 K.GQAAGGFFEDASEYDK.STax_Id=10090 Gene_Symbol=Aco2 Aconitate hydratase, mitochondrial

1 8.039592 4.4 85.2 1 K.IVYGHLDDPANQEIER.G1 5.704269 4.4 71.1 1 K.IVYGHLDDPANQEIER.G

Tax_Id=10090 Gene_Symbol=Acox2 Peroxisomal acyl-coenzyme A oxidase 2 Tax_Id=10090 Gene_Symbol=Acox2 acyl-Coenzyme A oxidase 2

1 4.778734 4.14 86.4 1 K.LAWSLGWSEDGPER.ITax_Id=10090 Gene_Symbol=Psip1 Isoform 1 of PC4 and SFRS1-interacting protein Tax_Id=10090 Gene_Symbol=Psip1 PC4 and SFRS1 interacting protein 1 Tax_Id=10090 Gene_Symbol=Psip1 PC4 and SFRS1 interacting protein 1 Tax_Id=10090 Gene_Symbol=Psip1 Isoform 2 of PC4 and SFRS1-interacting protein

1 5.191502 4.72 77.8 1 K.DIFPYSENKEK.YTax_Id=10090 Gene_Symbol=Acat1 Acetyl-CoA acetyltransferase, mitochondrial

1 7.181222 4.46 93.3 1 K.DGLTDVYNK.ITax_Id=10090 Gene_Symbol=Eif4g1 Isoform 1 of Eukaryotic translation initiation factor 4 gamma 1 Tax_Id=10090 Gene_Symbol=Eif4g1 eukaryotic translation initiation factor 4, gamma 1 isoform b Tax_Id=10090 Gene_Symbol=Eif4g1 Eif4g1 protein Tax_Id=10090 Gene_Symbol=Eif4g1 Isoform 2 of Eukaryotic translation initiation factor 4 gamma 1

1 6.140693 3.96 85.7 1 R.EFLAEGQDVGSFVAEK.K1 9.846534 4.4 96.3 1 K.KVEYTLGEESEAPGQR.T

Tax_Id=10090 Gene_Symbol=Dhx30 Isoform 3 of Putative ATP-dependent RNA helicase DHX30 Tax_Id=10090 Gene_Symbol=Dhx30 133 kDa protein Tax_Id=10090 Gene_Symbol=Dhx30 Isoform 2 of Putative ATP-dependent RNA helicase DHX30 Tax_Id=10090 Gene_Symbol=Dhx30 Isoform 1 of Putative ATP-dependent RNA helicase DHX30

1 7.977248 4.25 70 1 K.DSGPLSDPITGKPYMPLSEAEEVR.L1 5.754465 4.25 54.7 1 K.DSGPLSDPITGKPYMPLSEAEEVR.L

Tax_Id=10090 Gene_Symbol=Smarca5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 5.333396 4.12 50.9 1 R.NFTMDTESSVYNFEGEDYREK.Q

Tax_Id=10090 Gene_Symbol=Znfx1 Zinc finger, NFX1-type containing 1 1 8.038834 3.8 77.8 1 R.VCQPDEVTQIFFGFEDEPDAR.F

Tax_Id=10090 Gene_Symbol=2610101N10Rik Isoform 3 of U2-associated protein SR140 Tax_Id=10090 Gene_Symbol=2610101N10Rik Isoform 1 of U2-associated protein SR140 Tax_Id=10090 Gene_Symbol=2610101N10Rik Isoform 2 of U2-associated protein SR140

21 4.348661 3.86 40 1 K.AAAEIYEEFLAAFEGSDGNK.VTax_Id=10090 Gene_Symbol=Wdr3 WD repeat-containing protein 3

1 8.489558 3.64 85.7 3 R.AWDIDYLQEIDDPEEPEPK.KTax_Id=10090 Gene_Symbol=Naa16 NMDA receptor-regulated 1-like protein

1 5.406163 4.25 57.7 1 R.EANLFQESLEHIETYEK.LTax_Id=10090 Gene_Symbol=Ctnna1 Catenin alpha-1

1 7.598214 3.58 76.9 1 R.TPEELDDS(79.9663)DFETEDFDVR.STax_Id=10090 Gene_Symbol=Lonp2 Isoform 3 of Peroxisomal Lon protease homolog 2

1 4.419359 4.4 77.3 1 K.SREELGELSEQFYR.YTax_Id=10090 Gene_Symbol=Farsb Phenylalanyl-tRNA synthetase beta chain Tax_Id=10090 Gene_Symbol=Farsb Putative uncharacterized protein

1 3.795538 4.4 90 1 K.DRYDSFIELQEK.LTax_Id=10090 Gene_Symbol=Krt6b Keratin, type II cytoskeletal 6B Tax_Id=10090 Gene_Symbol=- 24 kDa protein Tax_Id=10090 Gene_Symbol=Krt6b keratin complex 2, basic, gene 6b Tax_Id=10090 Gene_Symbol=Krt6a 50 kDa protein Tax_Id=10090 Gene_Symbol=Gm5414 Type II keratin Kb14 Tax_Id=10090 Gene_Symbol=Krt6a Keratin, type II cytoskeletal 6A

1 5.298876 6.56 94.4 2 R.NTKQEIAEINR.MTax_Id=10090 Gene_Symbol=Krt25 Keratin, type I cytoskeletal 25 Tax_Id=10090 Gene_Symbol=Krt15 Keratin, type I cytoskeletal 15 Tax_Id=10090 Gene_Symbol=Krt15 keratin 15 Tax_Id=10090 Gene_Symbol=Krt27 Keratin, type I cytoskeletal 27

1 5.56328 6.56 100 2 K.VTMQNLNDR.LTax_Id=10090 Gene_Symbol=Ranbp2 E3 SUMO-protein ligase RanBP2

1 6.448595 3.96 83.3 1 R.FLGLLYEVEENIDK.A1 7.322464 4.19 53 2 R.KAEDIENDALSPEEQEECKNYLR.K1 8.100997 3.86 65.5 1 K.EMLNSVMQELEDYSEGGTLYK.N

Tax_Id=10090 Gene_Symbol=Mtap1b microtubule-associated protein 1B 1 5.683447 3.96 76 1 R.SWDTNLIECNLDQELK.L1 7.244415 4.53 46.1 1 K.SSHLPTEVTEKPQAVPVSFEFSEAKDENER.A

Tax_Id=10090 Gene_Symbol=Larp1 Isoform 1 of La-related protein 1 1 7.398113 4.12 66.7 1 K.DFQEETVKDYEAGQLYGLEK.F

Tax_Id=10090 Gene_Symbol=Gemin4 gemin 4 1 9.237851 3.86 64.5 1 R.EPDLVLSLLETVMEVISSDR.V

Tax_Id=10090 Gene_Symbol=Zc3h18 Isoform 1 of Zinc finger CCCH domain-containing protein 18 Tax_Id=10090 Gene_Symbol=Zc3h18 conserved nuclear protein Nhn1 isoform a

1 6.292406 3.8 76.9 2 R.DTTLEPYADPYYDYEIER.FTax_Id=10090 Gene_Symbol=Cpsf2 Cleavage and polyadenylation specificity factor subunit 2

1 5.307503 4.25 71.4 1 K.DGEEEIVYAVDFNHK.RTax_Id=10090 Gene_Symbol=Gtpbp4 Nucleolar GTP-binding protein 1

1 3.570447 4.42 67.6 1 K.KLEELEKEEELR.TTax_Id=10090 Gene_Symbol=Rpn2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

Tax_Id=10090 Gene_Symbol=Rpn2 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Rpn2 Ribophorin II

1 6.945693 3.96 90 2 R.NIVEEIEDLVAR.LTax_Id=10090 Gene_Symbol=Krt79 Keratin, type II cytoskeletal 79

1 5.232953 6.56 81.2 1 K.NKYEDEINKR.T3 5.401463 6.56 75 2 K.NKYEDEINKR.T

Tax_Id=10090 Gene_Symbol=Ndufv1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Tax_Id=10090 Gene_Symbol=Ndufv1 50 kDa protein Tax_Id=10090 Gene_Symbol=Ndufv1 42 kDa protein

3 6.060776 5.8 77.8 3 R.HFRPELEDR.MTax_Id=10090 Gene_Symbol=Setx Isoform 1 of Probable helicase senataxin

1 5.103107 4.25 64.6 2 K.VDRDDYYDLQEVLTCLFK.V1 6.259566 4.12 46.2 1 R.IVQGSDVLEADSDEPDDHRVSEPLAISNEK.Q

Tax_Id=10090 Gene_Symbol=Polrmt DNA-directed RNA polymerase, mitochondrial Tax_Id=10090 Gene_Symbol=Polrmt DNA-directed RNA polymerase Tax_Id=10090 Gene_Symbol=Polrmt 102 kDa protein Tax_Id=10090 Gene_Symbol=Polrmt Protein

1 6.749115 3.8 75 1 R.LAFADEVMEEILDSADNPLTGR.KTax_Id=10090 Gene_Symbol=Mia3 Isoform 2 of Melanoma inhibitory activity protein 3

1 6.761082 3.69 69 1 K.ESSPLEEAEVLDDIQDLIYFVR.YTax_Id=10090 Gene_Symbol=Myo1e myosin IE

1 6.762895 3.96 77.8 1 R.DVLFMDLIELMQSSELPFIK.S1 5.636689 3.96 50.8 1 R.DVLFMDLIELMQSSELPFIK.S

Tax_Id=10090 Gene_Symbol=Nol6 Isoform 2 of Nucleolar protein 6 Tax_Id=10090 Gene_Symbol=Nol6 Isoform 1 of Nucleolar protein 6

1 5.403205 4.03 64.3 1 R.ATEDPEVMELAFEGMDKEK.ATax_Id=10090 Gene_Symbol=Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 Tax_Id=10090 Gene_Symbol=Atp1a2 104 kDa protein Tax_Id=10090 Gene_Symbol=Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide, isoform CRA_c Tax_Id=10090 Gene_Symbol=Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2

1 9.447263 3.96 96.3 2 K.GVGIISEGNETVEDIAAR.LTax_Id=10090 Gene_Symbol=Eftud2 116 kDa U5 small nuclear ribonucleoprotein component Tax_Id=10090 Gene_Symbol=Eftud2 elongation factor Tu GTP binding domain containing 2 isoform b

1 7.747073 3.96 81.5 1 K.GLAEDIENEVVQITWNR.KTax_Id=10090 Gene_Symbol=Aass Alpha-aminoadipic semialdehyde synthase, mitochondrial

1 6.73292 4.57 59.1 1 R.KTDGVYDPVEYEKYPER.YTax_Id=10090 Gene_Symbol=Hspa4l Isoform 1 of Heat shock 70 kDa protein 4L Tax_Id=10090 Gene_Symbol=Hspa4l 64 kDa protein Tax_Id=10090 Gene_Symbol=Hspa4l Isoform 2 of Heat shock 70 kDa protein 4L

1 9.65062 3.96 100 1 K.TSFEEGTGECEVFSK.NTax_Id=10090 Gene_Symbol=Cdk11b Isoform 1 of Cell division protein kinase 11 Tax_Id=10090 Gene_Symbol=Cdk11b Cell division cycle 2-like 1

1 4.416415 3.86 81.8 1 R.DLLSDLQDISDSER.KTax_Id=10090 Gene_Symbol=Dpp4 Dipeptidyl peptidase 4 Tax_Id=10090 Gene_Symbol=Dpp4 dipeptidylpeptidase 4 isoform 2

1 7.832625 3.96 90 1 R.LGTLEVEDQIEAAR.QTax_Id=10090 Gene_Symbol=Gnl2 Nucleolar GTP-binding protein 2 Tax_Id=10090 Gene_Symbol=Gnl2 guanine nucleotide binding protein-like 2

1 6.667898 3.86 95.2 1 K.IESWENAEDFLEK.LTax_Id=10090 Gene_Symbol=Ddx5 Probable ATP-dependent RNA helicase DDX5

1 7.661357 4.14 94.4 1 R.TTYLVLDEADR.MTax_Id=10090 Gene_Symbol=Ikbkap Elongator complex protein 1

1 10.11748 3.86 90.3 1 K.EGSPLEGLALLEALSEVVQSVEK.LTax_Id=10090 Gene_Symbol=Slk Isoform 1 of STE20-like serine/threonine-protein kinase Tax_Id=10090 Gene_Symbol=Slk Isoform 2 of STE20-like serine/threonine-protein kinase

1 9.467294 3.8 83.3 1 R.DLNPEEFWEIIGELGDGAFGK.VTax_Id=10090 Gene_Symbol=Vars Valyl-tRNA synthetase

1 9.283513 4.12 62.3 1 K.VPLEVQEADEAKLQQTEAELR.KTax_Id=10090 Gene_Symbol=Acly Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=Acly ATP-citrate synthase

1 9.517322 3.86 86.7 1 R.SFDELGEIIQSVYEDLVAK.GTax_Id=10090 Gene_Symbol=Ubap2 Ubiquitin-associated protein 2

1 10.00603 3.69 88.9 2 K.NSVEEWTTEDWTEDLSETK.VTax_Id=10090 Gene_Symbol=Parp1 Isoform 1 of Poly [ADP-ribose] polymerase 1 Tax_Id=10090 Gene_Symbol=Parp1 Isoform 2 of Poly [ADP-ribose] polymerase 1 Tax_Id=10090 Gene_Symbol=Parp1 Putative uncharacterized protein

1 5.287633 4.25 72 1 R.GGSDDSSKDPIDVNYEK.LTax_Id=10090 Gene_Symbol=Prpf40a Isoform 1 of Pre-mRNA-processing factor 40 homolog A Tax_Id=10090 Gene_Symbol=Prpf40a Isoform 2 of Pre-mRNA-processing factor 40 homolog A

1 4.610203 4.25 62.8 1 R.FVKEPAFEDITLESER.KTax_Id=10090 Gene_Symbol=Actn2 Alpha-actinin-2 Tax_Id=10090 Gene_Symbol=Actn2 actinin alpha 2

1 10.56102 5.63 88.5 3 R.KHEAFESDLAAHQDR.VTax_Id=10090 Gene_Symbol=Cul3 Cullin-3

1 6.885262 3.96 100 1 K.GLTEQEVETILDK.ATax_Id=10090 Gene_Symbol=Hspa1l Heat shock 70 kDa protein 1-like owl|P36604| 78 KD GLUCOSE REGULATED PROTEIN HOMOLOG PRECURSOR (GRP 78) (IMMUNOGLOBULIN... owl|P49118| 78 KD GLUCOSE REGULATED PROTEIN HOMOLOG PRECURSOR (GRP 78) (IMMUNOGLOBULIN... Tax_Id=10090 Gene_Symbol=Hspa1a Spermatid-specific heat shock protein 70 (Fragment)

1 5.409415 4.46 94.7 4 K.VEIIANDQGNR.TTax_Id=10090 Gene_Symbol=Uggt1 UDP-glucose:glycoprotein glucosyltransferase 1

1 5.583222 4.12 57.1 1 R.IIGPLEDNELFNQDDFHLLENIILK.TTax_Id=10090 Gene_Symbol=Ap3d1 AP-3 complex subunit delta-1

1 7.901838 3.86 96.6 1 K.EQAADTEAAQEVTQLLVER.LTax_Id=10090 Gene_Symbol=Ganab Isoform 2 of Neutral alpha-glucosidase AB Tax_Id=10090 Gene_Symbol=Ganab Isoform 1 of Neutral alpha-glucosidase AB

1 5.707495 3.96 75 1 R.DDNSVELTVAEGPYK.ITax_Id=10090 Gene_Symbol=Xrn2 Isoform 1 of 5'-3' exoribonuclease 2 Tax_Id=10090 Gene_Symbol=Xrn2 Isoform 2 of 5'-3' exoribonuclease 2

1 10.101 3.86 95.8 1 K.NEDEMMVAIFEYIDR.LTax_Id=10090 Gene_Symbol=Dhx15 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 Tax_Id=10090 Gene_Symbol=Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 isoform 1

1 7.252671 3.86 95.2 3 R.EVDDLGPEVGDIK.ITax_Id=10090 Gene_Symbol=Krt75 Keratin, type II cytoskeletal 75 Tax_Id=10090 Gene_Symbol=4732456N10Rik hypothetical protein LOC239673

2 5.766051 4.46 83.3 1 K.AQYEDIANR.S

Tax_Id=10090 Gene_Symbol=Usp9x Probable ubiquitin carboxyl-terminal hydrolase FAF-X 11 5.749953 4.25 35.4 1 K.YFLPIIEMVPQFLENLTDEELKK.E

1 6.511574 3.86 73.1 1 K.IELFVGGELIDPGDDR.KTax_Id=10090 Gene_Symbol=Nup155 Nuclear pore complex protein Nup155

1 8.708921 4.25 68.8 2 K.SSTAISSIAADGEFLHELEEK.MTax_Id=10090 Gene_Symbol=Rrp12 RRP12-like protein

1 11.16311 3.86 78.6 2 K.SQAPETTMDQDPEVAFTEK.STax_Id=10090 Gene_Symbol=Nop14 Nucleolar protein 14

1 6.435698 4.25 90 1 R.DAMHEMEEMIETK.GTax_Id=10090 Gene_Symbol=Krt76 Keratin, type II cytoskeletal 2 oral

1 5.442219 4.46 92.9 2 K.AQYEDIAQK.STax_Id=10090 Gene_Symbol=Ptprk Receptor-type tyrosine-protein phosphatase kappa

1 7.276418 4.12 65.6 1 R.KESEETIIQTDEDVPGPVPVK.STax_Id=10090 Gene_Symbol=D6Wsu116e Isoform 1 of WASH complex subunit FAM21 Tax_Id=10090 Gene_Symbol=D6Wsu116e Isoform 2 of WASH complex subunit FAM21

1 8.561105 3.64 61.5 1 K.TNLFEDDDDDEVDLFAIAK.DTax_Id=10090 Gene_Symbol=Lars Leucyl-tRNA synthetase, cytoplasmic

1 7.937214 3.96 88 2 K.NMIDAGDALIYMEPEK.QTax_Id=10090 Gene_Symbol=Dhx9 Isoform 3 of ATP-dependent RNA helicase A Tax_Id=10090 Gene_Symbol=Dhx9 Isoform 1 of ATP-dependent RNA helicase A

1 5.968409 3.86 73.1 2 R.ELDALDANDELTPLGR.ITax_Id=10090 Gene_Symbol=Mthfd1l 111 kDa protein Tax_Id=10090 Gene_Symbol=Mthfd1l Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1 7.864249 3.96 90.5 1 K.EIGLLADEIEIYGK.STax_Id=10090 Gene_Symbol=Sec23a Protein transport protein Sec23A

1 5.521858 5.8 94.4 2 R.SWHDIEKDNAK.Yno descriptionno description

1 4.292123 4.46 92.9 1 R.DYQELMNVK.LTax_Id=10090 Gene_Symbol=Tpr nuclear pore complex-associated protein Tpr

1 6.238305 3.96 77.3 2 R.ELQELQDSLNVER.E1 7.568615 4.25 73.3 1 R.KLELDILPLQEANAELSEK.S1 6.184297 4.25 58.8 1 R.KLELDILPLQEANAELSEK.S

Tax_Id=10090 Gene_Symbol=Setx Isoform 2 of Probable helicase senataxin 1 6.259566 4.12 46.2 1 R.IVQGSDVLEADSDEPDDHRVSEPLAISNEK.Q

Tax_Id=10090 Gene_Symbol=Dhx57 Isoform 2 of Putative ATP-dependent RNA helicase DHX57 Tax_Id=10090 Gene_Symbol=Dhx57 Isoform 3 of Putative ATP-dependent RNA helicase DHX57 Tax_Id=10090 Gene_Symbol=Dhx57 Isoform 1 of Putative ATP-dependent RNA helicase DHX57

1 7.555579 3.96 77.8 1 K.VNLELIEALLEWIVDGK.HTax_Id=10090 Gene_Symbol=Skiv2l2 Superkiller viralicidic activity 2-like 2 Tax_Id=10090 Gene_Symbol=Skiv2l2 Putative uncharacterized protein

1 8.035909 3.86 95.2 1 R.DLDVEGTDEPIFGK.KTax_Id=10090 Gene_Symbol=Ssrp1 Isoform 2 of FACT complex subunit SSRP1 Tax_Id=10090 Gene_Symbol=Ssrp1 81 kDa protein Tax_Id=10090 Gene_Symbol=Ssrp1 Structure specific recognition protein 1 Tax_Id=10090 Gene_Symbol=Ssrp1 Isoform 1 of FACT complex subunit SSRP1

1 5.748786 4.14 100 1 R.SFDFEIETK.QTax_Id=10090 Gene_Symbol=Tln1 Talin-1

Tax_Id=10090 Gene_Symbol=Tln1 talin 1 1 8.238468 3.69 34.1 1 K.GTEWVDPEDPTVIAENELLGAAAAIEAAAK.K

Tax_Id=10090 Gene_Symbol=Ascc3 activating signal cointegrator 1 complex subunit 3 isoform 2 1 6.433653 4.03 44.1 1 R.LKPECSTEELLSILSDAEEYTDLPVR.H

Tax_Id=10090 Gene_Symbol=Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Tax_Id=10090 Gene_Symbol=Cad Cad-pending protein Tax_Id=10090 Gene_Symbol=Cad Cad protein

1 5.783606 4.25 48.5 1 R.MAEIGEHVAPSEAANSLEQAQAAAER.LTax_Id=10090 Gene_Symbol=Dhx37 DEAH (Asp-Glu-Ala-His) box polypeptide 37

1 4.662844 4.25 81.8 1 R.ELFEELDRPAASEK.ETax_Id=10090 Gene_Symbol=Dync1h1 Cytoplasmic dynein 1 heavy chain 1

1 6.281786 4.12 55.9 1 R.KLVPLLLEDGGDAPAALEAALEEK.S1 7.454871 3.8 53.6 1 K.LVPLLLEDGGDAPAALEAALEEK.S5 4.773167 4.12 38.1 1 K.VFYEEELDVPLVLFNEVLDHVLR.I

Tax_Id=10090 Gene_Symbol=Parp4 poly (ADP-ribose) polymerase family, member 4 58 4.422593 4.25 45.8 1 K.QTSEGAIEYYESYVEDLKR.Q

Tax_Id=10090 Gene_Symbol=Macf1 microtubule-actin crosslinking factor 1 Tax_Id=10090 Gene_Symbol=Macf1 Microtubule-actin crosslinking factor 1

1 4.526801 3.89 42.5 1 R.SLLEILNSAADILINSSEIDEDEIRDEK.A2 5.826045 3.69 65.5 1 R.LFGEDEVEVLNWLAEVEDK.L

Tax_Id=10090 Gene_Symbol=Huwe1 Isoform 2 of E3 ubiquitin-protein ligase HUWE1 Tax_Id=10090 Gene_Symbol=Huwe1 HECT, UBA and WWE domain containing 1 Tax_Id=10090 Gene_Symbol=Huwe1 HECT, UBA and WWE domain containing 1 Tax_Id=10090 Gene_Symbol=Huwe1 Isoform 4 of E3 ubiquitin-protein ligase HUWE1

1 6.825401 4.03 40.8 2 K.VPVSEGLEHSDLPDGTGEFLDAWLMLVEK.MTax_Id=10090 Gene_Symbol=Svil Supervillin Tax_Id=10090 Gene_Symbol=Svil Protein Tax_Id=10090 Gene_Symbol=Svil 230 kDa protein Tax_Id=10090 Gene_Symbol=Svil Svil protein Tax_Id=10090 Gene_Symbol=Svil Archvillin

1 8.004736 3.8 77.8 1 R.SPVELEEDFDVIFDPYAPK.LTax_Id=10090 Gene_Symbol=Myh11 smooth muscle myosin heavy chain 11 isoform 1

1 8.968273 3.69 100 6 K.TQLEELEDELQATEDAK.LTax_Id=10090 Gene_Symbol=Ankrd17 Isoform 3 of Ankyrin repeat domain-containing protein 17 Tax_Id=10090 Gene_Symbol=Ankrd17 Isoform 1 of Ankyrin repeat domain-containing protein 17 Tax_Id=10090 Gene_Symbol=Ankrd17 ankyrin repeat domain protein 17 isoform b

1 6.076171 3.96 81 1 K.NASILLEELDLEK.LTax_Id=10090 Gene_Symbol=Prpf8 Pre-mRNA-processing-splicing factor 8 Tax_Id=10090 Gene_Symbol=Prpf8 Pre-mRNA processing factor 8

1 8.842952 3.8 81.5 1 R.DINLQDEDWNEFNDINK.ITax_Id=10090 Gene_Symbol=Ahnak AHNAK nucleoprotein isoform 1

1 8.508979 3.8 64.3 2 K.GPSVDVEVPDVDLECPDAK.L1 5.888625 3.96 76 1 K.VDIEGPNVNIEGPEGK.L

Tax_Id=10090 Gene_Symbol=Bat2l2 HLA-B associated transcript 2-like 2 Tax_Id=10090 Gene_Symbol=Bat2l2 Isoform 1 of Protein BAT2-like 2 Tax_Id=10090 Gene_Symbol=Bat2l2 Isoform 3 of Protein BAT2-like 2 Tax_Id=10090 Gene_Symbol=Bat2l2 Isoform 5 of Protein BAT2-like 2

1 7.922378 4.4 86.2 1 R.DQMEGSPNSSESFEHIAR.S

Tax_Id=10090 Gene_Symbol=Gcn1l1 GCN1 general control of amino-acid synthesis 1-like 1 Tax_Id=10090 Gene_Symbol=Gcn1l1 Putative uncharacterized protein Tax_Id=10090 Gene_Symbol=LOC100047016 similar to GCN1 general control of amino-acid synthesis 1-like 1

1 3.951211 3.8 64 1 K.QLDDEEVSEFALDGLK.QTax_Id=10090 Gene_Symbol=Mtap1b Microtubule-associated protein 1B

1 5.683447 3.96 76 1 R.SWDTNLIECNLDQELK.LTax_Id=10090 Gene_Symbol=Chd5 chromodomain helicase DNA binding protein 5 isoform 2 Tax_Id=10090 Gene_Symbol=Chd5 chromodomain helicase DNA binding protein 5 isoform1

1 5.826113 3.96 80 1 R.ENEFSFEDNAIR.GTax_Id=10090 Gene_Symbol=Macf1 Isoform 3 of Microtubule-actin cross-linking factor 1 Tax_Id=10090 Gene_Symbol=Macf1 Isoform 1 of Microtubule-actin cross-linking factor 1 Tax_Id=10090 Gene_Symbol=Macf1 Isoform 2 of Microtubule-actin cross-linking factor 1 Tax_Id=10090 Gene_Symbol=Macf1 Microtubule-actin crosslinking factor 1b Tax_Id=10090 Gene_Symbol=Macf1 Microtubule-actin crosslinking factor 1

1 4.526801 3.89 42.5 1 R.SLLEILNSAADILINSSEIDEDEIRDEK.ATax_Id=10090 Gene_Symbol=Ubr4 Isoform 1 of E3 ubiquitin-protein ligase UBR4 Tax_Id=10090 Gene_Symbol=Ubr4 Isoform 3 of E3 ubiquitin-protein ligase UBR4 Tax_Id=10090 Gene_Symbol=Ubr4 Isoform 5 of E3 ubiquitin-protein ligase UBR4

2 5.916657 6.56 43.8 1 R.KDPELFSGLASNILNFITTSMLNSR.NTax_Id=10090 Gene_Symbol=- Ring finger protein 213

1 6.993504 4.42 44.8 1 K.DSHIFQDFWQETAESLNTLDKDPR.ETax_Id=10090 Gene_Symbol=Mll2 similar to myeloid/lymphoid or mixed-lineage leukemia 2 Tax_Id=10090 Gene_Symbol=Mll2 myeloid/lymphoid or mixed-lineage leukemia 2 Tax_Id=10090 Gene_Symbol=Mll2 myeloid/lymphoid or mixed-lineage leukemia 2

22 4.670767 9.53 35.5 1 K.IQKQLDQVRKQQKEHT(79.9663)NLMAEYR.NTax_Id=10090 Gene_Symbol=Acacb acetyl-Coenzyme A carboxylase beta Tax_Id=10090 Gene_Symbol=Acaca Isoform 2 of Acetyl-CoA carboxylase 1 Tax_Id=10090 Gene_Symbol=Acaca Isoform 1 of Acetyl-CoA carboxylase 1

1 7.58938 3.96 95 1 K.EASFEYLQNEGER.LTax_Id=10090 Gene_Symbol=Plec plectin isoform 1b2alpha Tax_Id=10090 Gene_Symbol=Plec plectin isoform 1c Tax_Id=10090 Gene_Symbol=Plec plectin isoform 12alpha Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1B of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1E of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1F of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1 of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1D of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1A of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1G of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-1H of Plectin-1 Tax_Id=10090 Gene_Symbol=Plec Isoform PLEC-0 of Plectin-1

1 7.600145 3.69 63 3 R.GLFDEEMNEILTDPSDDTK.GTax_Id=10090 Gene_Symbol=Eppk1 Epiplakin

1 9.410539 3.86 89.3 1 K.LGVMELVSLLTQIIEETEER.L1 5.904853 3.86 50 1 K.LGVMELVSLLTQIIEETEER.L

K.ILDSVGIEADDDRLNKVISELNGKNIEDVIAQGVGK.L

K.LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK.K

K.KEES(79.9663)EES(79.9663)DDDMGFGLFD.-

K.KKAS(79.9663)LQSGQEGPGDSPGSQFSK.WK.KKASLQSGQEGPGDSPGS(79.9663)QFSK.W

K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.PK.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFR.PK.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.P

K.WPASPGS(79.9663)HSNDDFDNWSTFRPR.TK.WPASPGSHS(79.9663)NDDFDNWSTFRPR.TK.WPAS(79.9663)PGSHSNDDFDNWSTFRPR.T

K.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFRPR.TK.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFRPR.T

R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVH.SR.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSL.VR.TSSNAS(79.9663)TISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNAST(79.9663)ISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.MR.TSS(79.9663)NASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TS(79.9663)SNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.MR.T(79.9663)SSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLS(79.9663)PIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.MN.ASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

R.LSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.MR.LS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M

K.YTYGQSSMS(79.9663)PLPQMPMQTLQDSK.SK.YTYGQSS(79.9663)MSPLPQMPMQTLQDSK.S

K.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.VK.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.VK.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.VK.ELLTSDS(79.9663)PPHNDIMSPVDPGVAQPNSR.VK.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.VK.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.VK.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.V

R.VLGQNVMMGPNSVMPAYGSQAS(79.9663)HNK.MR.VLGQNVMMGPNSVMPAYGS(79.9663)QASHNK.M

R.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.TR.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.TR.LTPVKT(79.9663)PLQVPLSHPMQMSALGSYSSVSSCNGYGR.MK.TPLQVPLSHPMQMSALGSYSSVSSCNGYGR.M

R.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.NR.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.N

R.LDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVK.T

K.KKAS(79.9663)LQSGQEGPGDSPGSQFSK.WK.KKASLQSGQEGPGDSPGS(79.9663)QFSK.W

K.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.PK.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFR.PK.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFR.P

K.WPASPGS(79.9663)HSNDDFDNWSTFRPR.TK.WPASPGSHS(79.9663)NDDFDNWSTFRPR.TK.WPAS(79.9663)PGSHSNDDFDNWSTFRPR.TK.WPAS(79.9663)PGS(79.9663)HSNDDFDNWSTFRPR.TK.WPAS(79.9663)PGSHS(79.9663)NDDFDNWSTFRPR.T

R.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVH.SR.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSL.VR.TSSNAS(79.9663)TISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNAST(79.9663)ISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.MR.TSS(79.9663)NASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TS(79.9663)SNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.MR.T(79.9663)SSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.MR.TSSNASTISGRLS(79.9663)PIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.MN.ASTIS(79.9663)GRLSPIMTEQDDLGDGDVHSLVYPPSAAK.M

R.LSPIMT(79.9663)EQDDLGDGDVHSLVYPPSAAK.MR.LS(79.9663)PIMTEQDDLGDGDVHSLVYPPSAAK.M

K.YTYGQSSMS(79.9663)PLPQMPMQTLQDSK.SK.YTYGQSS(79.9663)MSPLPQMPMQTLQDSK.S

K.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.VK.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.VK.ELLTSDSPPHNDIMS(79.9663)PVDPGVAQPNSR.VK.ELLTSDS(79.9663)PPHNDIMSPVDPGVAQPNSR.VK.ELLTS(79.9663)DSPPHNDIMSPVDPGVAQPNSR.VK.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.VK.ELLTSDS(79.9663)PPHNDIMS(79.9663)PVDPGVAQPNSR.V

R.VLGQNVMMGPNSVMPAYGSQAS(79.9663)HNK.MR.VLGQNVMMGPNSVMPAYGS(79.9663)QASHNK.M

R.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.TR.TLPHVVNTMPHTSAMNRLT(79.9663)PVK.TR.LTPVKT(79.9663)PLQVPLSHPMQMSALGSYSSVSSCNGYGR.M

K.TPLQVPLSHPMQMSALGSYSSVSSCNGYGR.M

R.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.NR.MGVLHQEKLPSDLDGMFIERLDCDMESIIR.N

K.LPSDLDGMFIERLDCDMESIIRNDPMDGDTLDFNFDNVLPNQSFPHSVK.T

R.NDPMDGDTLDFNFDNVLPNQSFPHS(79.9663)VK.TR.NDPMDGDTLDFNFDNVLPNQS(79.9663)FPHSVK.T

K.AAFDDAIAELDTLS(79.9663)EESYKDSTLIMQLLR.D

R.DNLTLWTSDMQGDGEEQNKEALQDVEDENQ.-R.DNLTLWTSDMQGDGEEQNKEALQDVEDENQ.-

R.LAEQAERYDDMAAAMKNVTELNEPLSNEER.N

K.TAFDDAIAELDTLNEDS(79.9663)YKDSTLIMQLLR.DK.TAFDDAIAELDT(79.9663)LNEDSYKDSTLIMQLLR.D

R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.KR.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.KR.YLAEVAAGDDKKGIVDQSQQAYQEAFEISKK.E

R.VEMEDAHTAVVGIPHGLDNWSFFAVYDGHAGSR.V

K.LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK.K

K.KEES(79.9663)EES(79.9663)DDDMGFGLFD.-



K.VEGEESPADPAAAAASSNSDGGNPVAMQER.D


R.SRLPKSPPY(79.9663)TAFLGNLPYDVTEDSIK.DR.SRLPKS(79.9663)PPYTAFLGNLPYDVTEDSIK.D

R.SQSSDTEQPS(79.9663)PTSGGGKVAAVQPPEEGPSRK.D

Tax_Id=10090 Gene_Symbol=C1qbp Complement component 1 Q subcomponent-binding protein, mitochondrial

R.NYQQNYQNSESGEKNEGSESAPEGQAQQR.R

Tax_Id=10090 Gene_Symbol=Ywhab Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

K.DPSAAPNEGFCSAGVQTEAGVADLTWVGDK.GK.DPSAAPNEGFCSAGVQTEAGVADLTWVGDK.G

Tax_Id=10090 Gene_Symbol=Ywhae Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

R.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.KR.YLAEVAAGDDKKGIVDQSQQAYQEAFEISK.KR.YLAEVAAGDDKKGIVDQSQQAYQEAFEISKK.E

R.SVWGGSVGSAGLAGMGGIQTEKETMQDLNDR.L

K.CGSGPVHISGQHLVAVEEDAES(79.9663)EDEDEEDVK.LK.CGSGPVHISGQHLVAVEEDAES(79.9663)EDEDEEDVKLLGMSGK.RK.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVK.KK.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVK.KK.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.SK.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.S

K.VKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.SK.LDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKK.S

K.WAHDKFS(79.9663)GEEGEIEDDES(79.9663)GTENREEK.D

R.SVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSK.YR.NYQQNYQNSESGEKNEGSESAPEGQAQQR.R

R.LCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLR.HR.LCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLR.H

K.EALKDEYDDLSDLTPAQQETLSDWDSQFTFK.Y

K.NYSPYYNTIDDLKDQIVDLTVGNNKTLLDIDNTR.M

K.NRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLR.H

R.RQLAFST(79.9663)VGTPDYIAPEVFMQTGYNK.LR.QLAFST(79.9663)VGTPDYIAPEVFMQTGYNK.L

K.SIDDTSNFDEFPESDILKPTVTTSSHPETDYK.N

K.FPEEDEILEKDEALEDEDSKKDDGISFSSQTAWAGSER.D

R.ASLEAAIADAEQRGEMAIKDAQTKLAELEAALQR.A

K.AEAKEES(79.9663)EES(79.9663)DEDMGFGLFD.-

R.VGATAAVYSAAILEYLTAEVLELAGNASKDLK.V

R.EHGGPEGMDPDGVIESNWNEIVDNFDDMNLK.E

Tax_Id=10090 Gene_Symbol=Hist2h3c1;Hist1h3e;Hist1h3f;Hist2h3c2;Hist2h3b;Hist1h3b;Hist1h3d;Hist1h3c Histone H3.2 Tax_Id=10090 Gene_Symbol=Hist2h3c1;Hist1h3e;Hist1h3f;Hist2h3c2;Hist2h3b;Hist1h3b;Hist1h3d;Hist1h3c histone cluster 2, H3c1

R.FQSSAVMALQEASEAYLVGLFEDTNLCAIHAK.RR.FQSSAVMALQEASEAYLVGLFEDTNLCAIHAK.R

R.FQSAAIGALQEASEAYLVGLFEDTNLCAIHAK.R

K.CVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFR.D

Tax_Id=10090 Gene_Symbol=Hist1h4c;Hist1h4m;Hist1h4j;Hist1h4i;Gm11275;Hist1h4a;Hist1h4f;Hist2h4;Hist1h4h;Hist4h4;Hist1h4k;4930558J22Rik;Hist1h4d;Hist1h4b Histone H4

R.AHLNDLENIVPFLGIGLLYSLSGPDLSTALMHFR.I

K.FELT(79.9663)GIPPAPRGVPQIEVTFDIDANGILNVSAVDK.S

K.ILDKCNEIISWLDKNQTAEKEEFEHQQKELEK.V

K.LGEESKEPLS(79.9663)DEDEEDNDDVEPISEFR.F

K.FPEEDEILEKDEALEDEDSKKDDGISFSSQTAWAGSER.D

R.DYLGDFIEHYAQLGPSQPPDLAQAQDEPRR.A

K.RAACEQLHQQQQQQQEETTAATLLLQGEEEGEED.-

R.TGPAATTLSDTAAAESLVDSSEVTVIGFFKDVESDSAK.Q

K.FLESGGQDGAGDDEDLDLEEALEPDMEEDDDQK.AK.FLESGGQDGAGDDEDLDLEEALEPDMEEDDDQKAVKDEL.-

R.SVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSR.Y

K.GYEDYLQSPLQPLMDNLESQTYEVFEKDPIK.Y

K.AEAKEES(79.9663)EES(79.9663)DEDMGFGLFD.-

K.VEWAALVQAADTLNLAEVPKEPTEGYEHDETFLR.K

Tax_Id=10090 Gene_Symbol=Hist1h2an;Hist1h2ao;Hist1h2ad;Hist1h2ac;Hist1h2ae;Hist1h2ag;Hist1h2ai;RP23-480B19.10;Hist1h2ab Histone H2A type 1

R.VGAGAPVYLAAVLEYLTAEILELAGNAARDNK.KR.VGAGAPVYLAAVLEYLTAEILELAGNAARDNKK.TR.VGAGAPVYLAAVLEYLTAEILELAGNAARDNKK.T

K.FELT(79.9663)GIPPAPRGVPQIEVTFDIDANGILNVSAVDK.S

K.ILDKCNEIISWLDKNQTAEKEEFEHQQKELEK.V

R.AIEALKEFNEDGALAVLQQFKDSDLSHVQNK.SR.AIEALKEFNEDGALAVLQQFKDSDLSHVQNK.S

K.IIPTLEEGLQLPS(79.9663)PTATSQLPLESDAVECLNYQHYK.G

K.IDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVK.Q

K.GATPAEDDEDKDIDLFGS(79.9663)DEEEEDKEAAR.LR.KLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNK.I

R.DRIDNLIDPGSPFLEFSQFAGYQLYGDEEVPAGGIITGIGR.V

Tax_Id=10090 Gene_Symbol=Echs1 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, isoform CRA_c K.ALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDK.A

R.FLSEHPGGEEVLLEQAGADATESFEDVGHSPDAR.E

R.LTCNDTSAALLISHIVQSEIGDFDEALDREHLAK.N

K.GYEDYLQSPLQPLMDNLESQTYEVFEKDPIK.Y

K.NNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLK.G


R.SRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLR.G


K.DSRPSQAAGDNQGDEAKEQTFSGGTSQDIK.G

K.SPVGKS(79.9663)PPATGSAYGSSQKEESAASGGAAYSK.R

K.WAHDKFS(79.9663)GEEGEIEDDES(79.9663)GTENREEK.D

K.DSRPSQAAGDNQGDEAKEQTFSGGTSQDIK.G

K.SPVGKS(79.9663)PPATGSAYGSSQKEESAASGGAAYSK.R

Tax_Id=10090 Gene_Symbol=Ubb;Rps27a;Ubc similar to ubiquitin/40S ribosomal protein S27a fusion protein isoform 2 Tax_Id=10090 Gene_Symbol=Gm8430 similar to fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a

K.KLDALTTGFGFPVGAATLADEVGVDVAQHVAEDLGK.A

K.KPLPDHVSIVEPKDEILPTT(79.9663)PISEQK.G

Tax_Id=10090 Gene_Symbol=Rpl10;LOC100048223;LOC100048462;Gm10041;Gm13891 60S ribosomal protein L10

R.LQAALDNEAGGRPAMEPGNGSLDLGGDAAGR.S

R.AKS(79.9663)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK.I

K.SQEPISNDQKVS(79.9663)DDDKEKGEGALPTGK.S

R.WKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.IK.GENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.I

Tax_Id=10090 Gene_Symbol=Ndufb4;Gm3244;Gm3873 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

K.ELGENLTDEELQEMIDEADRDGDGEVNEQEFLR.I

K.IDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVK.Q

R.RQLAY(79.9663)STVGTPDYIAPEVFMQTGYNK.LR.QLAYST(79.9663)VGTPDYIAPEVFMQTGYNK.L

R.SRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLR.G

R.LALALEALQAQAQAMPSLSALEELREELQEVR.G

K.LSELEDLLPSRPEVPNVIGETEEVELQEFDSTR.GTax_Id=10090 Gene_Symbol=Pdha1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

R.KEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVR.G


R.SVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSR.Y

K.IDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVK.S

Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

R.KPPTFGDASVIALELLNSGYEFDEGSIIFNQFK.S

Tax_Id=10090 Gene_Symbol=Psmd3 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3, isoform CRA_b K.AKPPPGGEQEPPPPAPQDVEMKEEAAAGSGSTGEGDGK.A

K.IQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSR.Y

K.LNWLSVDFNNWKDWEDDS(79.9663)DEDMSNFDR.F

R.MLPHAPGVQMQAIPEDAIPEES(79.9663)GDEDEEDPDKR.I

K.IDPTVTMMQVEEKPDVTYSDVGGCKEQIEK.L

R.WKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.IK.GENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGR.I

R.ECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK.K

K.DVAEEITNYRPTIDTLHEQASALPQAHAESPDVK.G

Tax_Id=10090 Gene_Symbol=Sdha Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial K.GSDWLGDQDAIHYMTEQAPASVVELENYGMPFSR.T

R.GMVWNTDLVETLELQNLMLCALQTIYGAEAR.K

R.QQNLILSYAEDETDVEGTVNGVTHTSTGGR.T

K.ALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDK.A

K.ETAVMDDLTEVLCSSPGNSGATGDGANSGASGAQNHVK.E

R.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.IR.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.I

R.ECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK.K

Tax_Id=10090 Gene_Symbol=Rps13;Gm10159;LOC100044992;Gm6573;LOC100048340 40S ribosomal protein S13

K.DVAEEITNYRPTIDTLHEQASALPQAHAESPDVK.G


Tax_Id=10090 Gene_Symbol=Acaa2 Acetyl-Coenzyme A acyltransferase 2 (Mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_k

Tax_Id=10090 Gene_Symbol=Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit isoform b R.KPPTFGDASVIALELLNSGYEFDEGSIIFNQFK.S

Tax_Id=10090 Gene_Symbol=LOC100046823 similar to proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) isoform 2 Tax_Id=10090 Gene_Symbol=LOC100046823 similar to proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) isoform 1

K.KEES(79.9663)EES(79.9663)EDDMGFGLFD.-

R.MLPHAPGVQMQAIPEDAVHEDS(79.9663)GDEDGEDPDKR.I

R.HPDSHQLFIGNLPHEVDKSELKDFFQNFGNVVELR.I

R.S(79.9663)KSPPPPEEEAKDEEEDQTLVNLDTYTSDLHFQISK.D

K.ANFSLPEKCDYMDEVTYGELEKEEAQPIVTK.Y

Tax_Id=10090 Gene_Symbol=Ndufb11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

K.IIPTLEEGLQLPS(79.9663)PTATSQLPLESDAVECLNYQHYK.G

K.LADDVDLEQVANETHGHVGADLAALCSEAALQAIR.K

R.GLATFCLDKDALRDEYDDLSDLNAVQMESVR.E

R.GNEFFCEVDEDYIQDKFNLTGLNEQVPHYR.QR.GNEFFCEVDEDYIQDKFNLTGLNEQVPHYR.Q

Tax_Id=10090 Gene_Symbol=Mup2;Mup7;Mup1 Novel member of the major urinary protein (Mup) gene family

K.GQDMETEAHQNKLEEMINELAVAMTAVK.H

K.VMFPVFLGEQIPPETLAATLAELDVNLQVLEDK.F

Tax_Id=10090 Gene_Symbol=LOC100044630;Tomm20;Gm14494 Mitochondrial import receptor subunit TOM20 homolog

Tax_Id=10090 Gene_Symbol=LOC100045982 similar to MOSC domain-containing protein 1, mitochondrial isoform 1

K.AYSGSQIDILIDQGKDDEFLSNGQLLPDNFIAACTEK.K

K.NIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEK.G

R.CSEGVFLLTTTPRPVIVEPLEQLDDEDGLPEK.L

K.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.AK.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.A

R.ASNSPEQSSCLEGLDSEVPGPTEDLKTDLGK.GR.GTGGNQREDEVQAGDTTVEDQVGTVASGPAK.Q

K.NIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEK.G

R.TIFDTPDEDPNYNPLPEERPGGFAWGEGQR.L

R.DFETLENWMLQTLNEEPATPEPEAEPPRAPELK.Q

Tax_Id=10090 Gene_Symbol=2810422J05Rik;Gm11808;Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1

Tax_Id=10090 Gene_Symbol=Gm11517 similar to ubiquitin A-52 residue ribosomal protein fusion product 1 isoform 1

Tax_Id=10090 Gene_Symbol=Gm13215 similar to fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a

R.RLSNPPVENSSYKNDDDEDVIILEENSTPKPAVDLEVK.S

K.IALESVGQPEEQMESGNCS(79.9663)GGDDDWTHLSSK.E

K.IFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPK.L

R.ASNSPEQSSCLEGLDSEVPGPTEDLKTDLGK.GR.GTGGNQREDEVQAGDTTVEDQVGTVASGPAK.Q

R.VISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEK.VR.VISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEK.V

K.KAQLNIGNVLPVGTMPEGTIVCCLEEKPGDR.G

K.AGNALGGVDNEEEEELGDEAMMALDQNLASLFK.E

Tax_Id=10090 Gene_Symbol=Hist1h2bf;Hist1h2bl;Hist1h2bn;LOC100046213;Hist1h2bj Histone H2B type 1-F/J/L

Tax_Id=10090 Gene_Symbol=Gm13646;Hist1h2be;Hist1h2bc;Hist1h2bg;LOC665622 Histone H2B type 1-C/E/G

K.EPLYVGVDDDKEVATVDGLEQGYVVCPSEK.R

R.KLEAEPDLPLVQPVFITVDPERDDVAAMAR.Y

K.VFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTK.T

R.DFNSIFSEMGAWTLPSHSPELPGPESETPGER.L


Tax_Id=10090 Gene_Symbol=Gm10240;Rpl21;Gm15150;Gm10163;LOC100046290;Gm14648;LOC100044606 ribosomal protein L21

K.AQETQDESAVLWLDEIQGGIWQSNKDTQEAQR.F

R.SDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDK.VR.SDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDK.V

R.NAEISDVAPVEETRELSPEQS(79.9663)TAGKPSDGSSALDR.A

R.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.IR.YPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELR.I

R.EHGGPEGMDPDGVIESNWNEIVDNFDDMNLK.E

K.GGNLRDKLDGNELDLSLSDLNEVPVKELAALPK.A

Tax_Id=10090 Gene_Symbol=Ndufa9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Tax_Id=10090 Gene_Symbol=Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1

K.LHLDEDYPCSLVGNWNTWYGEQDQAVHLWR.F

K.NPLPPQPQVPETPWADEGGSVYHLTDEDFDQFVK.E

K.GATPAEDDEDKDIDLFGS(79.9663)DEEEEDKEAAR.L

R.LQRPKEES(79.9663)S(79.9663)EDENEVSNILR.S

K.VPTEEEDGSSLEADMECPNQRPTESSDVDK.N

K.RPAASSAAAASAAAS(79.9663)SPAGGGGEAQELLEHCGVCR.E

K.QGSGSSQPMEVQEGYGFGSDDPYSSAEPHVSGMK.R

Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 3 of Heterogeneous nuclear ribonucleoprotein U-like protein 1 R.RGRS(79.9663)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK.V

Tax_Id=10090 Gene_Symbol=Gadd45gip1 Growth arrest and DNA damage-inducible proteins-interacting protein 1

Tax_Id=10090 Gene_Symbol=Camk2a Isoform Alpha KAP of Calcium/calmodulin-dependent protein kinase type II subunit alpha

Tax_Id=10090 Gene_Symbol=Camk2a Isoform Alpha CaMKII of Calcium/calmodulin-dependent protein kinase type II subunit alpha

K.HAEQNGPVDGQGDNPGSQAAEHGADTAVPSDGDK.K

Tax_Id=10090 Gene_Symbol=Prkar2a Protein kinase, cAMP dependent regulatory, type II alpha, isoform CRA_b

R.VSSHVAATEGNPSDQSELESQMITGAGDSETAHNTENTESNEK.K

R.QPPMPLAEAEQLMEEWNEDLDGMEGFVLEGR.K

K.QVINEGEEPENFFWVGIGAQKPYDDDAEYMK.H

R.S(79.9663)LSVTS(79.9663)LGGLPVWEAER.L

K.VTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPR.E

K.DTLNPVAVPVS(79.9663)SPTATKPSPANTASPCTSNINPPR.A

K.GRADGDWDDQEVLDYFS(79.9663)DKESAK.Q

Tax_Id=10090 Gene_Symbol=Rpl35a;LOC100046034;LOC100044516;Gm10214;Gm10296;Gm13911;Gm10213;Gm15434;mCG_133520 60S ribosomal protein L35a

Tax_Id=10090 Gene_Symbol=Ppp2r2a Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Tax_Id=10090 Gene_Symbol=Ndufv2 Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Tax_Id=10090 Gene_Symbol=LOC100047628 similar to Chain L, Structural Basis Of Antigen Mimicry In A Clinically Relevant Melanoma Antigen System isoform 1



K.KADYQAVDDEIEANIEEIDANEEDIDDGFRR.L

Tax_Id=10090 Gene_Symbol=Gstz1 Brain cDNA, clone MNCb-6148, similar to Mus musculus glutathione transferase zeta 1 (maleylacetoacetate isomerase) (Gstz1), mRNA

R.VVDNPIYLSDMGAALTGAESHELQDVLEETNILK.R

Tax_Id=10090 Gene_Symbol=LOC633016 similar to Chromobox homolog 3 (HP1 gamma homolog, Drosophila) isoform 2

Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-2 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-9 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 similar to UDP-glucuronosyltransferase 1A8 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A1 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-7C Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glycosyltransferase 1 family, polypeptide A10 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A6B Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 UDP-glucuronosyltransferase 1-1 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5;Ugt1a6a UDP-glucuronosyltransferase 1-6

K.AFAGDIANQLATDAVQIFGGYGFNTEYPVEK.L

R.LSGAEPDDEEYQEFEEMLEHAEAAQDFASR.A

R.IDNADELLESFLEGFHDESTQVQLQLLTAIVK.L

Tax_Id=10090 Gene_Symbol=Dlst Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Tax_Id=10090 Gene_Symbol=Taf15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor

R.DYGPRPDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFK.Q

K.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.AK.FGTEELFKDEATDGGGDNKEGEDSSVIHYDDK.A


K.KYSADVMSEMAQIAEALLQAGANPNMQDSK.GTax_Id=10090 Gene_Symbol=Ppp2cb Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Tax_Id=10090 Gene_Symbol=Ppp2ca Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Tax_Id=10090 Gene_Symbol=Nedd4 Neural cell expressed, developmentally down-regulted gene 4, isoform CRA_c

K.VQVLLEEAKDLLSDWLDSTGGSEVTDNSIFSK.L

K.S(79.9663)GTPPRPGSVTNMQADECTATPQR.QK.SGT(79.9663)PPRPGSVTNMQADECTATPQR.QK.S(79.9663)GTPPRPGSVTNMQADECTAT(79.9663)PQR.Q

K.GRADGDWDDQEVLDYFS(79.9663)DKESAK.Q

K.DCDPNTGEIDEEGYEDEYVLEDLEVTVADHIQK.V

Tax_Id=10090 Gene_Symbol=Gm10284 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100047232 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1

Tax_Id=10090 Gene_Symbol=Gm13292 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm10358 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3 Tax_Id=10090 Gene_Symbol=Gm2451 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100048117 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1

Tax_Id=10090 Gene_Symbol=LOC100047232 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3

Tax_Id=10090 Gene_Symbol=Gm10358 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm10284 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2 Tax_Id=10090 Gene_Symbol=LOC100046806;Gm10327 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1

Tax_Id=10090 Gene_Symbol=Gm4609 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1

Tax_Id=10090 Gene_Symbol=LOC100045908 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=Gm2451 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 2

Tax_Id=10090 Gene_Symbol=Gm3839 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 1 Tax_Id=10090 Gene_Symbol=LOC100042025 similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoform 3

Tax_Id=10090 Gene_Symbol=Gm10293;Gapdh;LOC100042025;Gm10359;Gm2574;Gm5138;Gm12033;Gm3272 Glyceraldehyde-3-phosphate dehydrogenase

R.HTIQGDYIDTMEEIADLVGVRPNILPLVFTDPR.L

Tax_Id=10090 Gene_Symbol=Cct2 Brain cDNA, clone MNCb-1272, similar to Mus musculus chaperonin subunit 2 (beta) (Cct2), mRNA

R.HDSEQDNSDNNTIFVQGLGENVTIESVADYFK.Q

Tax_Id=10090 Gene_Symbol=LOC100045542 similar to FERMRhoGEF (Arhgef) and pleckstrin domain protein 1

R.LTCNDTSAALLISHIVQSEIGDFDEALDREHLAK.N

M.AVPAALIPPT(79.9663)QLVPPQPPISTSASSSGT(79.9663)TTSTSSATSSPAPSIGPP.A

Tax_Id=10090 Gene_Symbol=Dlst Isoform 2 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 1 of Heterogeneous nuclear ribonucleoprotein U-like protein 1 Tax_Id=10090 Gene_Symbol=Hnrnpul1 Isoform 2 of Heterogeneous nuclear ribonucleoprotein U-like protein 1

R.RGRS(79.9663)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK.V

K.ASAGHAVSITQDDGGADDWETDPDFVNDVSEK.E


K.ADHSSENAFVFGGPFLTDESSLLAFPEATEEEK.Q

K.KADYQAVDDEIEANIEEIDANEEDIDDGFRR.L

R.GAPIIPVAAKPGGPEAPETEAPQGISELIELLK.S

Tax_Id=10090 Gene_Symbol=Ecsit Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

K.TVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVR.K

R.ERHAVLVEEFS(79.9663)QIRAES(79.9663)EINSKKR.V

Tax_Id=10090 Gene_Symbol=Gpx4 Isoform Mitochondrial of Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

Tax_Id=10090 Gene_Symbol=Gm13910 similar to Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

K.KYSADVMSEMAQIAEALLQAGANPNMQDSK.GR.GADMSVPDEKGNPPLWLALASNLEDIASTLVR.H

K.DTLNPVAVPVS(79.9663)SPTATKPSPANTASPCTSNINPPR.A

K.AVEGEGEPAAAHSDVLTEVEGPVDTAEASSDPHTEK.L

K.TIDAMDAWEDLTELGYHLADLPVEPHLGK.M

Tax_Id=10090 Gene_Symbol=Suclg2 Isoform 1 of Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Tax_Id=10090 Gene_Symbol=Suclg2 Isoform 2 of Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

Tax_Id=10090 Gene_Symbol=Serpinb6a serine (or cysteine) proteinase inhibitor, clade B, member 6a isoform a


R.WNDHDSPEEFNFASDVLDYWAQMEEEGK.R

R.YCSKPPGPAEAVGYFLYNLIDSMSDSEVQAK.E

K.QDAGSEPVTPASLAALQSDVQPVGHDYVEEVR.N

R.VAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSR.NR.VAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSR.N

K.LSGGEQQSSDAGLFKEEGDLDFLGQQDTDYR.S

Tax_Id=10090 Gene_Symbol=LOC100045982 similar to MOSC domain-containing protein 1, mitochondrial isoform 2

Tax_Id=10090 Gene_Symbol=Pgam5 Isoform 2 of Serine/threonine-protein phosphatase PGAM5, mitochondrial Tax_Id=10090 Gene_Symbol=Pgam5 Isoform 1 of Serine/threonine-protein phosphatase PGAM5, mitochondrial

Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-1 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-3 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Tax_Id=10090 Gene_Symbol=Gnas Isoform XLas-4 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Tax_Id=10090 Gene_Symbol=Gnas Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tax_Id=10090 Gene_Symbol=Gnas Isoform XLas-1 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

R.VEYELSEEGDEPQYLDLPSTATSVNIPDLLPGR.K

Tax_Id=10090 Gene_Symbol=Eps8l2 Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 2 Tax_Id=10090 Gene_Symbol=Eps8l2 Isoform 2 of Epidermal growth factor receptor kinase substrate 8-like protein 2

Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5;LOC100048744;LOC100048662 UDP glycosyltransferase 1 family polypeptide A13 Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 23 kDa protein Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 23 kDa protein Tax_Id=10090 Gene_Symbol=LOC632297;Ugt1a10;Ugt1a6b;Ugt1a7c;Ugt1a2;Ugt1a9;Ugt1a1;Ugt1a5 18 kDa protein

R.LPGQTEDPAELMLDNYDTMYLLDQPVIEHR.LTax_Id=10090 Gene_Symbol=Ppp2r1a Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Tax_Id=10090 Gene_Symbol=Aldh6a1 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Tax_Id=10090 Gene_Symbol=Gm4450 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 3 Tax_Id=10090 Gene_Symbol=Gm4450 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 1 Tax_Id=10090 Gene_Symbol=Gm10681 similar to 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase isoform 3

Tax_Id=10090 Gene_Symbol=Dak Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

R.DLLHIGTQARPDLFDLAVPMPEVLYEEVVEVDER.V

K.DKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCK.G

R.SGGDGGDEAEGSGVGAGEGETVQHFPLAR.P

Tax_Id=10090 Gene_Symbol=LOC100045629 similar to myocardial ischemic preconditioning upregulated protein 2 isoform 1

Tax_Id=10090 Gene_Symbol=Dlat Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Tax_Id=10090 Gene_Symbol=Tmpo Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma Tax_Id=10090 Gene_Symbol=Tmpo Isoform Delta of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma Tax_Id=10090 Gene_Symbol=Tmpo Isoform Epsilon of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

Tax_Id=10090 Gene_Symbol=Tmpo Isoform Beta of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

R.CTSNPCANGGQCQNRGPSRT(79.9663)CR.C

Tax_Id=10090 Gene_Symbol=Ddost Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

K.SLAYLSAATHGLDEEAESLKETFDPEKETIPDIDPNAK.L

K.LSGGEQQSSDAGLFKEEGDLDFLGQQDTDYR.S

R.LGEASDSELADADKASVASEVSTTSSTSKPPTGR.R

K.SSLAQPQMMVVSDVADMFVPLLDGFLVNVSESR.A

Tax_Id=10090 Gene_Symbol=- similar to Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

K.KPPAPPSPVQSQSPSTNWS(79.9663)PAVPAKK.A

Tax_Id=10090 Gene_Symbol=Ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

R.VEYELSEEGDEPQYLDLPSTATSVNIPDLLPGR.K

Tax_Id=10090 Gene_Symbol=Ppp2r2c Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Tax_Id=10090 Gene_Symbol=Saps3 Isoform 1 of Serine/threonine-protein phosphatase 6 regulatory subunit 3

K.EDNLKEFDQLDQENDDGWAGAHEEVDYTEK.LK.EDNLKEFDQLDQENDDGWAGAHEEVDYTEK.L

Tax_Id=10090 Gene_Symbol=Smarca5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Tax_Id=10090 Gene_Symbol=Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

K.VPVSEGLEHSDLPDGTGEFLDAWLMLVEK.M

K.IQKQLDQVRKQQKEHT(79.9663)NLMAEYR.N

Documents

fields.scripps.edufields.scripps.edu/published/foxo1_Tabas_… · XLS file · Web view · 2012-01-05Tax_Id=10090 Gene_Symbol=Glul 12 kDa protein FOXO_KO.36700.36700.3 K.CVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFR.D