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1 Clare Brown, Sean G. Young, Mick Tilford, Jenil Patel, Suman Maity, Jaimi Allen, Jyotishka Datta, Benjamin C. Amick III, Mark L. Williams* *corresponding author November 6, 2020

Fay W. Boozman College of Public Health - Clare Brown, Sean G. … · 2020. 11. 10. · Clare Brown, Sean G. Young, Mick Tilford, Jenil Patel, Suman Maity, Jaimi Allen, Jyotishka

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  • 1

    Clare Brown, Sean G. Young, Mick Tilford, Jenil Patel, Suman

    Maity, Jaimi Allen, Jyotishka Datta, Benjamin C. Amick III,

    Mark L. Williams*

    *corresponding author

    November 6, 2020

  • 2

    COVID-19 Forecasts, Projections, and Impact Assessments

    The University of Arkansas for Medical Sciences (UAMS) Fay W. Boozman College of

    Public Health (COPH) faculty conducted three types of assessments for this bi-weekly report: 1)

    short-term forecasts of confirmed and probable cases, hospitalizations, and deaths, 2) long-term

    projections of infections and hospitalizations; and 3) findings from the Arkansas Pandemic Poll.

    All forecasts and projections were developed using COVID-19 data from the Arkansas

    Department of Health through Nov. 1. All findings related to the Arkansas Pandemic Poll come

    from data collected by the COPH from Oct. 3 through Oct. 17.

    Summary points are:

    15-day models continue to predict increasing numbers of daily cases, hospitalizations, and deaths due to COVID-19. The 15-day model forecasts 112,101 cumulative

    confirmed COVID-19 cases in Arkansas by Nov. 16. Including confirmed and

    probable cases, the 15-day model forecasts 121,627 cases by Nov. 16.

    Fifteen-day models continue to show Arkansans between 35 and 59 will have the highest number of COVID-19 cases. Young adults 18 to 34 will have the second

    highest number of cases. These two age groups will make up around 68% of the

    COVID-19 caseload.

    All counties in Arkansas reported new COVID-19 cases in the past two weeks. Two counties had two-week rates of change greater than 100%, and 12 counties had rates

    of change greater than 50%.

    The 15-day models are forecasting 7,893 cumulative hospitalizations and 2,627 cumulative intensive care patients by Nov. 16.

    The trend for greatest number of hospitalizations continues to be in adults 60 to 74 years, who surpass the previously highest group of adults 35 to 59. Children younger

    than 17 continue to have the fewest number of hospitalizations.

    The mid-term model is forecasting hospitalizations by Dec. 30 will, if the forecast holds true, increase by 2,443 over hospitalizations on Nov. 1.

    The 15-day model is forecasting 2,202 cumulative deaths by Nov. 16.

    The long-term eSIR model suggests the pandemic will peak in March or April 2021 with between 20,000 and 63,000 active infections.

    There are strong differences in willingness to accept a COVID-19 vaccine by race/ethnicity. Blacks have lower COVID-19 vaccine acceptance than Hispanics and

    Whites. Differences by race/ethnicity appear to be centered on perceived vaccine

    safety.

    There are clear differences in willingness to accept a COVD-19 vaccine by acceptance of infection mitigation behaviors. Stronger beliefs about the necessity and

    effectiveness of COVID-19 mitigation behaviors are strongly correlated with greater

    willingness to accept a COVID-19 vaccine. This suggests addressing acceptance of

    mitigation behaviors is likely to positively impact vaccine acceptance.

    Despite differences by race/ethnicity and beliefs about mitigation behaviors, Arkansans in general appear to be tepid toward accepting a COVID-19 vaccine.

    .

  • 3

    COVID-19 Cases and Infection

    15-day forecast of confirmed COVID-19 cases in Arkansas. Figure 1 shows actual and

    forecast COVID-19 cases in Arkansas. The model forecasts Arkansas will reach a cumulative

    112,101 confirmed

    COVID-19 cases by

    Nov. 16, an increase of

    7,738 confirmed cases.

    As shown in Figure

    1, confirmed COVID-19

    cases continue to

    increase, with little

    change in the rate of the

    growth curve since early

    July. The model is

    forecasting a steady

    increase in cases over the

    next 15-days.

    The 15-day forecast

    in the last report was

    101,780 cumulative

    confirmed cases by Nov.

    1, around 2.4% less than the 104,239 confirmed cases reported on that date by the Arkansas

    Health Department.

    In addition to the 15-

    day forecast of

    confirmed cases, we

    forecast future cases

    using both confirmed

    and probable cases. The

    15-day forecast of

    cumulative confirmed

    and probable cases is

    121,627 by Nov. 16, as

    seen in Figure 2. As this

    is the first time we are

    providing this forecast,

    we cannot assess its

    accuracy. We will

    include this assessment

    in our next report.

    Figure 1 Forecast confirmed COVID-19 cases through Nov. 16

    Figure 2 Forecast confirmed plus probable COVID-19 cases through Nov. 16

    121,627

  • 4

    Confirmed cases are those identified using the PCR test. The Department of Health

    distinguishes between confirmed and probable cases. Probable cases are diagnosed using an

    antigen test, which is considered less reliable than the more commonly used PCR test. The

    Department of Health

    provides the number of total

    cases in Arkansas by adding

    the number of confirmed

    and probable tests together.

    Because the Department of

    Health was not including

    positive antigen tests until

    Sept. 2, we included only

    positive antigen tests on or

    after Sept. 2.

    Forecast confirmed

    cases by age and race. The

    greatest growth in cases will

    continue to be in adults 18

    to 59, as shown in Figure 3.

    The 15-day model is forecasting 39,846 confirmed cases in adults 35 to 59 by Nov. 16. The

    second highest growth will be in young adults 18 to 34. The model is forecasting 35,960

    cumulative confirmed cases in young adults 18 to 34 by Nov. 16. Together, these two age groups

    will account for 68% of the COVID-19 caseload in the state. The least growth will be in adults

    older than 75, with a projected 8,265 confirmed cases by Nov. 16.

    As shown in Figure 4,

    the 15-day model is

    forecasting increasing

    cases in all racial/ethnic

    groups in Arkansas.

    However, the model

    forecasts the increase will

    be greater in Whites.

    Indeed, if we compare the

    slopes for Blacks and

    Hispanics to that of

    Whites, the slopes are

    increasing far more

    modestly in Blacks and

    Hispanics. The 15-day

    model is forecasting

    60,826 cumulative

    confirmed COVID-19 cases among Whites by Nov. 16, an increase of approximately 10,000

    cases over the number reported through Nov. 1st.

    As shown in Table 1, we assessed the relative change in case rates by age and race/ethnicity

    from Oct. 19 to Nov. 1. The greatest relative change was among adults older than 75 and those

    60 to 74. The relative rate of increase was 16% and 13% respectfully. Those 17 or younger and

    Figure 3 Forecast COVID-19 cases through Nov. 16 by age

    Figure 4 Forecast COVID-19 cases through Nov. 16 by race

  • 5

    adults 35 to 59 both had relative rates of increase of 10% and 8%. Arkansans 18 to 34 had the

    lowest rate of change in the past two weeks.

    Table 1: Relative change in confirmed cases by race/ethnicity and age

    Increase Relative change

    Race/ethnicity

    White 4,871 11%

    Black 1,576 8%

    Hispanic 658 4%

    Age

    < 17

    18 to 34

    35 to 59

    60 to 74

    > 75

    1,162

    2,515

    3,272

    1,470

    981

    10%

    8%

    9%

    12%

    16%

    Map 1 Relative change in reported cases by County

  • 6

    The relative change in cases from Oct. 19 to Nov. 1 was greatest among Whites, 11%. Blacks

    had a relative change of 8%, and Hispanics 4%.

    Relative change in community COVID-19 cases. Map 1, on the previous page, shows the

    relative change in each county’s case rate in the last two weeks. The relative change is

    determined by calculating the percent change between case rates from the most recent two-week

    period, Oct. 19 to Nov. 1, with the case rates from the prior two-week period, Oct. 5 to Oct 18.

    Counties in red had the greatest relative change.

    Fewer counties are showing large change rates in this report than in the previous one.

    Counties with positive change rates greater than 50%, shown in red, continue to be concentrated

    in rural counties in Arkansas. In the current report, we identified 12 counties with a positive rate

    of change over 50%, compared to 17 counties in the previous report. Additionally, two counties

    had change rates greater than 100%. Cleveland County had a change rate of 483% and Sevier

    County 130%. Thirty-eight of the 75 counties in Arkansas had no change or negative change

    rates.

    It is important to note that the rate of change, if viewed without knowing underlying rates,

    may not tell the full story of a county’s COVID-19 burden. A steady rate of 250 cases per 10,000

    from one reporting period to the next would have a rate of change of 0%, even though the

    disease rate is

    high. There are

    a number of

    factors to

    consider

    beyond the

    underlying

    rate. Changes

    in rates can be

    affected by

    recent events.

    For example,

    ADH recently

    hosted two

    free mass

    testing events

    in Cleveland

    and Scott

    counties,

    which likely

    contributed to

    the high

    relative

    increases in

    those counties.

    While what can be said about a county’s COVID-19 burden is limited when assessing change

    rates alone, change rates are useful when combined with other data. Map 2 shows the number of

    COVID-19 cases per capita for each county. Per capita rates can be used along with data shown

    on Map 1 to draw conclusions about how COVID-19 is spreading throughout the state. Per capita

    Map 2 COVID-19 cases per 10,000 population, Oct. 19 to Nov. 1

  • 7

    rates are concerning when high. No county had a per capita rate in the last two weeks that

    exceeded 100 per 10,000. The three counties with the highest per capita rates in the last two

    weeks were Poinsett, 81, Craighead, 63, and Greene, 59.

    When data are combined to form an overall picture, what we can conclude, for example, is

    that Poinsett County has a high and slowly increasing caseload, compared to Cleveland County,

    which has a more modest, but rapidly increasing caseload. If we look at data from the two maps

    together, we can conclude that the pandemic has now firmly established itself in rural areas of

    the state, primarily in the northeastern and western counties of the state, with comparatively high

    case and relative change rates. We can also conclude the state would benefit from more

    widespread testing to better describe the scope and magnitude of the pandemic.

    COVID-19 positivity rates. Broadly defined, the COVID-19 positivity rate is the number of

    people who test positive for COVID-19 as a proportion of the number of people who have been

    tested. The positivity rate is an indicator of COVID-19 transmission in the state. A lower

    positivity rate is indicative of less transmission, and a higher rate is indicative of greater COVID-

    19 transmission. The positivity rate is dependent on the number of tests conducted. The positivity

    rate has also taken on greater significance as part of CDC guidelines for local schools having in-

    person classes. According to guidelines, the ideal positivity rate is less than 5%, but for practical

    purposes less than 10% is acceptable.

    Testing for

    COVID-19 in

    the state is on

    par with the

    national average

    (2.7/1,000

    versus

    3.9/1,000).

    Figure 5 shows

    the seven-day

    moving average

    of the positivity

    rates for

    Arkansas and

    the United

    States.

    Following the

    second week in

    May, the

    positivity rate in

    Arkansas increased and remained above the national average, except for two drops below the

    national average for short periods in August and September. The October positivity rate declined

    compared to rates in August and September. As of Oct. 31, the positivity rate in Arkansas was

    11%, higher than the national rate of 6.8%.

    Mid-term forecast of COVID-19 cases. The mid-term forecast provides a look at what

    might happen between the end of November to the beginning of 2021. We used a SEIR model to

    predict a seven-day rolling average.

    Figure 5 COVID-19 positivity rate for Arkansas and the U.S.

  • 8

    As shown in

    Figure 6, the

    model forecasts

    150,777

    cumulative

    cases on Dec.

    31. The growth

    rate will be

    2.6% per week.

    If the forecast

    holds true,

    Arkansas will

    add 50,000 new

    cases over the

    number

    reported to the

    Department of Health on Oct. 31. If we include estimated active cases not reported, largely

    because they are asymptomatic, we can expect an additional 20,000 active cases.

    Long-term projection of active cases. As shown above in Figure 7, the eSIR model is

    projecting the peak of the epidemic in Arkansas will be in late March or early April, with a mean

    prediction of 35,718 active infections. The light-pink shaded region in Figure 7 shows the

    uncertainty in the model (90% confidence interval), while the red line shows the mean estimate.

    Summary. The short-term forecast describes significant continued growth in COVID-19

    cases over the next 15 days. A plausible reason for this outcome is that portions of the

    community do not see themselves at high risk of infection and are behaving accordingly. A

    second plausible reason is pandemic fatigue. While not measured, it is described by many as

    people and households simply tired of following CDC and state guidelines. The greatest number

    Figure 7 Projected active COVID-19 infections

    Figure 6 Projected COVID-19 cases through Dec. 31

  • 9

    of cases are in adults between the ages of 18 and 59. Adults younger than 60 may have

    developed the impression that COVID-19 is not a significant risk for them or if infected they will

    not develop serious disease.

    For the long-term projections the timing and number of cases at the peak of the pandemic has

    not changed substantially from the previous reports, although the lower bound of the confidence

    interval has expanded downward. What this suggests is a greater amount of uncertainty in the

    model.

  • 10

    COVID-19 Hospitalizations and ICU Admissions

    Short-term forecasts of hospitalizations. Figure 8 shows the 15-day forecast for COVID-19

    hospitalizations in the state on Nov. 16. The estimated trend in hospitalizations is consistent with

    the increasing trend in confirmed cases. The 15-day model forecasts there will be 7,893

    cumulative hospitalizations in Arkansas by Nov. 16, an increase of 801 or 11% in

    hospitalizations over Nov. 1.

    Figure 9 below shows a similar growth pattern for patients needing intensive care. The 15-

    day model is forecasting 2,627 COVID-19 cumulative intensive care patients by Nov. 16, an

    increase of 197 or 8% over Nov. 1.

    In our last report, forecast

    hospitalizations and patients needing

    intensive care were very close to actual

    numbers, within 1% and 2%

    respectively. The model forecast 7,109

    cumulative hospitalizations by Nov. 1

    while the actual number was 7,092, a

    difference of 17 hospitalizations.

    Cumulative intensive care patients were

    forecasted to be 2,401, less than 30

    fewer than the actual number of

    intensive care patients on Nov. 1 of

    2,430.

    Similar to the previous report, the

    forecast of hospitalizations by age,

    shown in Figure 10 on the next page,

    presents a similar growth pattern

    compared to the growth pattern for cases

    shown in Figure 3, and emphasizes the

    reasons why mitigation of COVID-19 is

    important, especially for older adults.

    The current report forecast the greatest

    number of hospitalizations will be in

    adults 60 to 74. Adults 60 to 74 are

    forecast to have 2,545 cumulative

    hospitalizations by Nov. 16, increasing

    by 290 hospitalization. This compares

    to 2,454 hospitalizations in adults 35 to

    59, the second highest number.

    The hospitalization rate of adults 60

    to 74 diagnosed with COVID-19 is 18%,

    almost three times higher than the

    hospitalization rate of 6% among adults

    Figure 8 Forecast hospitalizations

    Figure 9. Forecast intensive care

  • 11

    35 to 59.

    Hospitalizations in

    adults 35 to 59 are

    forecast to increase

    by 138. The group

    with the third highest

    number of

    hospitalizations are

    adults over 75.

    Almost one quarter of

    adults over 75

    diagnosed with

    COVID-19 will be

    hospitalized.

    The groups with

    the fewest

    hospitalizations are young adults between 18 and 34 and children 17 or younger. Young adults

    have a relatively low rate of growth in hospitalizations compared to older adults. Nonetheless,

    the number of actual hospitalizations is not trivial. Young adults 18 to 34 are forecast to have

    719 hospitalizations by Nov. 16, an increase of 42. The relative change in hospitalizations by

    race/ethnicity and age are shown in Table 2.

    Children younger than 17 are forecast to have approximately 163 cumulative hospitalizations

    by Nov. 16. While the number of hospitalizations is small compared to other age groups, this

    group continues to have growing hospitalization numbers. The number of actual hospitalizations

    in children under 17 was 147 on Nov. 1. An increase of 16 hospitalizations represents an increase

    of 11% in just two weeks.

    Table 2: Relative change in hospitalizations by race/ethnicity and age

    Increase Relative change

    Race/ethnicity

    White 283 8%

    Black 65 4%

    Hispanic 15 2%

    Age

    < 17*

    18 to 24

    35 to 59

    60 to 74

    > 75

    *

    30

    94

    143

    135

    *

    5%

    4%

    7%

    9%

    *number of cases too small to report

    Figure 10 Forecast COVID-19 hospitalizations by age

  • 12

    Our forecasts of hospitalizations by age groups for Nov. 1 were fairly accurate and close to

    actual hospitalizations observed for all groups, with differences less than 11% between actual

    and forecasted hospitalizations across all age groups.

    We also forecasted

    hospitalizations by race as

    shown in Figure 11. All races

    are forecast to show steady

    increases in hospitalizations.

    As expected, the majority of

    hospitalizations were noted in

    Whites. By Nov. 16, we

    expect hospitalizations to rise

    from 3,822 to 4,545 among

    Whites, 1,919 to 2,331 among

    Blacks, and 744 to 925 among

    Hispanics.

    Figure 11

    Forecast COVID-19 hospitalizations by race

  • 13

    Hospitalizations by county. Evaluating the distribution of hospitalizations across the state

    can help understand the impact COVID-19 may have on regional and state health system

    resources. We created two graphics related to county-level hospitalization. For privacy reasons,

    three counties with fewer than 10 hospitalizations were excluded from the analyses.

    Map 3 provides the hospitalization rates per 100,000 residents. Make note that these are per

    100,000, rather than per 10,000 like the maps related to positive cases. Sixty-seven of the 75

    counties in Arkansas have hospitalization rates per 100,000 that are greater than 100. This means

    that one out of every 1,000 people has been hospitalized for COVID-19 in nearly every Arkansas

    county. The counties with the highest per capita hospitalization rates are Lee, 614.0, Chicot,

    584.7, and Hempstead, 557.0. For these three counties, one of every 200 residents have been

    hospitalized for COVID-19.

    Map 3 Hospitalization Rates per 100,000 Residents by County of Residence

  • 14

    Similarly, understanding the percent of COVID-19 positive patients who have been

    hospitalized can be an important measure of disease spread and an indicator of future

    hospitalizations when combined with the number of new local cases. Map 4 provides the percent

    of confirmed COVID-19 cases hospitalized. For example, a value of 5% means that 5 out of 100

    of COVID-19 cases from that county were hospitalized. Fourteen counties have rates above 10,

    which means that one of every 10 COVID-19 cases in those 14 counties were hospitalized. There

    are nine counties with less than 5% hospitalization rates. The counties with the highest rates are

    Cleburne, 12.4%, Lawrence, 12.3%, and Sharp, 12.3%. These are rural counties.

    Mid-term hospitalization projections through Dec. 31. We introduce, for the first time,

    mid-term projections for hospitalizations. Based on the SEIR prediction of the total cases, we

    factored in the hospitalization rate, estimated over 15-day average to adjust for higher variability,

    to predict the total number of cases requiring hospitalization at any given time. As shown in

    Figure 12, the number of hospitalizations will continue to increase through the end of December.

    Map 4 Percent of Positive Cases that were Hospitalized by County of Residence

  • 15

    By Dec. 31, hospitalizations are forecast to reach 9,537 cumulative hospitalizations, an increase

    of 2,443 over Nov. 1. These results are based on limited data and as we receive more data we

    will have greater confidence in our projection.

    Long-Term Projections. Table 3, below, shows the long-term projections for

    hospitalizations. By April 7, it is expected there will be 857 individuals hospitalized for COVID-

    19 disease based on over 35,000 active infections. Of these hospitalizations, 299 will require

    intensive care. We also consider a worst-case scenario. The worst-case scenario projects 1,426

    hospitalizations based on almost 60,000 active infections on March 30. If the projected number

    of hospitalizations holds true, the number of patients requiring intensive care would be 499.

    Summary. The 15-day models are forecasting the greatest number of hospitalizations due to

    COVID-19 will be in adults 60 to 74. COVID-19 disease is more severe in older people. The

    rapid increase in the growth trend, with a 17% hospitalization rate in this group, highlights the

    growing impact COVID-19 will have on the state’s hospitals. The forecast cases and

    hospitalizations continue to be worrisome for older Arkansans and emphasizes the need for

    continuing mitigation practices by all age groups. Almost a fourth of adults 60 and over who test

    Table 3: Long-term projections of active infections, hospitalizations, intensive care, and

    ventilations in Arkansas

    Mean-Case Estimates Worst-Case Estimates

    Peak Date April 7 March 30

    Active Infections 35,718 59,421

    Hospitalizations 857 1,426

    Intensive Care 299 499

    Ventilations 104 174

    Figure 12 Projected hospitalizations by Dec. 31

  • 16

    positive for COVID-19 are hospitalized. Currently, growth in COVID-19 cases among these age

    groups is relatively slow. But, with family holidays approaching and anticipated mixing of

    family members and friends of all ages, infection rates in older adults could markedly increase. If

    this were to happen, hospitalizations will also dramatically increase.

    The second highest hospitalizations were noted in adults 35 to 59. The high growth in

    COVID-19 cases and hospitalization among adults 18 to 65 is important. The vast majority of the

    workforce is between the ages of 18 and 65. Even if not hospitalized with COVID-19 disease,

    these adults will likely be out of the workforce for extended periods of time in isolation. Isolating

    persons with COVID-19 will have a ripple effect, as persons in close contact with infected

    persons are quarantined. As the pandemic in Arkansas continues to increase, isolating infected

    persons and quarantining their contacts will result in significant numbers of people unable to

    work.

  • 17

    COVID-19 Deaths

    15-day forecast of COVID-19 deaths. The 15-day model is forecasting 2,202 deaths by

    Nov. 16, as shown in Figure 13. The forecast is an increase of 357 or 16% over deaths reported

    on Nov. 1. Our previous forecast of COVID-19 deaths was within 5% of actual numbers. The

    model forecast 1,925 deaths by Nov. 1. The actual number was 1,845, a difference of 80.

    Mid-term projections

    of COVID-19 deaths. Mid-

    term projections provide a

    look at what might happen

    between the end of

    November and late-

    December. As has been

    stressed previously, the

    farther out in time a model

    projects, the less confidence

    we have in model outcomes.

    We use a SEIR model to

    predict a seven-day rolling

    average.

    As shown in Figure 14,

    the seven-day rolling

    average forecast of

    cumulative deaths in the

    state on Dec. 31 is 2,887.

    This is an increase of 1,042

    deaths compared to actual

    deaths on Nov. 1. The

    weekly growth rate of deaths

    through the end of the year

    is forecast to be 2.4%.

    To assess changes in the

    number of deaths since the

    last report, we measured the

    relative change in the

    number of cumulative deaths

    by age and by race/ethnicity

    from Oct. 19 to Nov. 1. The

    growth rates in deaths align

    with the growth rates in

    hospitalizations, with the

    exception of the younger 3

    age categories. The younger

    age categories show lower growth rates in deaths. This is consistent with the expectation that

    COVID-19 will cause milder disease in children and young adults compared to older adults. The

    relative change in deaths by race/ethnicity and age are shown in Table 4.

    Figure 13 Projected COVID-19 deaths through Nov. 16

    Figure 14 Projected COVID-19 deaths through Dec. 31

  • 18

    Summary. Consistent with increasing cases and hospitalizations over the last two weeks,

    deaths rates continued to increase and are expected to do so for the foreseeable future. The recent

    spikes in cases and hospitalizations may be reflected in an increasing death rate in the upcoming

    forecasts. As the slope of the 15-day forecast suggests, the number of deaths is likely to increase

    at a high rate in the next two weeks. If we compare the 15-day and mid-term forecasts,

    November and December are likely to see 1,000 deaths, which is half again as many COVID-19

    deaths in Arkansas as between March and October. Unfortunately, given current data, we cannot

    take the Thanksgiving holiday into account. But, with the gathering of families over the holidays,

    we are likely to see a sharp increase in cases, hospitalizations, and deaths similar to previous

    holidays.

    Table 4: Relative change in deaths by race/ethnicity and age

    Increase Relative change

    Race/ethnicity

    White 96 9%

    Black 65 4%

    Hispanic* - 1%

    Age

    < 17*

    18 to 24*

    35 to 59*

    60 to 74

    > 75

    -

    -

    -

    33

    79

    -

    5%

    3%

    7%

    8%

    *number of cases too small to report

  • 19

    Arkansas Pandemic Poll

    The Fay W. Boozman College of Public Health at the University of Arkansas for Medical

    Sciences (COPH) instituted a random digit dial (RDD) telephone poll to assess Arkansan’s views

    on the COVID-19 pandemic. The pulse poll captures a random sample of adults in Arkansas

    using random digit dialing. However, to ensure the results reflect the adult population of

    Arkansas as a whole, we weighted survey results based on age and gender. To date, almost 9,000

    Arkansans have completed the survey.

    In this report, we examine vaccine acceptance among Arkansans. Vaccine acceptance is the

    willingness to take a vaccine. We used a recently validated measure for vaccine acceptance

    designed for the general population. We asked the respondent to focus on COVID-19 when

    answering questions (see Methodological Notes). Data on vaccine acceptance was collected

    between Oct. 3 and Oct. 17. The sample used for this assessment was 1,100.

    Vaccine Acceptance in Arkansas

    Figure 14 shows the mean levels of vaccine acceptance using a 10-item scale. In addition to

    the overall measure, the scale has five subscales. The total scale score is the average score on all

    10 items. Responses on a single item ranged from 1 to 7, with 4 signifying neither agreement nor

    disagreement. The higher the

    overall score, the more a person

    is willing to accept a vaccine.

    The overall vaccine acceptance

    score of the 1,100 Arkansas who

    participated in the poll is 5.0.

    High vaccine acceptance would

    be 6.0 or greater, so 5.0 is

    slightly better than neither agree

    nor disagree.

    As shown in Figure 14,

    ‘safety’ refers to the subscale

    measuring perceived vaccine

    safety, and had a mean value of 4.7. ‘Effect’ refers to perceived vaccine effectiveness and the

    belief that vaccines are necessary. This subscale had a mean value of 5. ‘Accept’ refers to

    subscale measuring acceptance of vaccine selection and scheduling. This subscale had a mean of

    5.1. “Value’ measures perceived value and effect of a vaccine. This subscale had a mean of 5.3.

    Perceived legitimacy of authorities to require vaccinations is measured by the subscale ‘Legit.” It

    had a sample mean of 4.9. Overall, no scale or subscale mean was significantly greater than 4.

    This suggests Arkansans are very tepid when it comes to accepting a coronavirus vaccine.

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Score Safety Effect Accept Value Legit

    Figure 14 Mean Values for Vaccince Accpetance and the

    Subscales in Arkansas

  • 20

    Variation in vaccine acceptance by

    race/ethnicity. There were no differences in

    vaccine acceptance by sex or age. However,

    racial/ethnic differences were observed, as

    shown in Figure 15. Acceptance was highest

    among Hispanics (5.3) and lowest among

    Blacks (4.5). The mean acceptance score for

    Whites was 5.1. The differences across

    race/ethnicity were relatively large and

    statistically significant.

    There were also differences across all

    acceptance subscales by race/ethnicity, as

    shown in Figure 16. Blacks score lowest on

    all subscales, but especially on perceived

    vaccine safety. Blacks reported their highest

    scores on believing vaccines have positive value, 4.7 compared to 5.6 for Hispanics, and 5.2 for

    Whites. On the subscale, selection of vaccines and their scheduling, the mean for Blacks is 4.8

    compared to 5.6 for Hispanics and 5.2 for

    Whites.

    Overall, Blacks were least willing to

    accept vaccines. This finding suggests the

    state should make special efforts to

    understand how Blacks perceive the

    acceptability of vaccines differently than

    Whites and Hispanics, and develop

    communication and distribution programs

    accordingly. However, the results also

    argue for a primary need to move the

    whole Arkansas population higher in

    terms of vaccine acceptance.

    Vaccine acceptance by pandemic

    characteristics. We considered vaccine acceptance by beliefs about other pandemic mitigation

    behaviors: wearing a mask regularly in public, agree wearing a mask helps stop the spread of

    COVID-19, perceived chance of getting COVID, agree with the decision to allow large groups to

    gather, and past two weeks attended church, temple, or other religious gathering. Other questions

    were explored but the pattern is the same.

    Chances of getting COVID-19. We asked respondents what they thought the chances are of

    getting the coronavirus. There were differences across all vaccine acceptance subscales. As

    shown in Figure 17 on the next page, respondents who said there was no chance they would get

    infected had a mean vaccine acceptance score of 4.6 compared to a mean of 5.1 for those who

    felt there was some chance they would get infected. There were similar differences across

    vaccine effectiveness (5.1 vs. 4.6) and legitimacy of government to require vaccines (5.0 vs. 4.5).

    Vaccine safety had the lowest values for both any chance (4.9) and no chance (4.2) of getting

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Safety Effect Accept Value Legit

    Figure 16 Vaccine Acceptance Subscales by

    Race/Ethnicity

    White Black Hispanic

    3

    3.5

    4

    4.5

    5

    5.5

    6

    White Black Hispanic

    Figure 15 Overall Vaccine Acceptance Scale by

    Race/Ethnicity

  • 21

    COVID-19. The acceptance of scheduling of vaccines (5.2 vs. 4.8) and vaccines have a positive

    value (5.4 vs. 4.9) had the highest mean scores.

    Mask Wearing.

    We asked three

    questions about

    mask wearing. First,

    we asked if a

    respondent had

    regularly worn a

    mask in the past

    two weeks. Second,

    we asked if a

    respondent thought

    the mask helped

    protect him/her

    from the getting the

    coronavirus. Third,

    we asked if a

    respondent believed

    a state order requiring citizens to wear a face mask in public is needed.

    Figure 18 shows the results for persons who said they regularly wear masks in the past two

    weeks. For this group, the overall vaccine acceptance score was 5.1 compared to 4.1 for those

    who did not

    regularly wear a

    mask. Differences

    across the

    subscales are most

    striking for vaccine

    safety (4.7 vs. 3.7)

    and legitimacy of

    the government to

    require vaccines

    (5.0 vs. 3.6).

    Differences

    between regular

    mask wearers and

    non-regular mask

    wearers in vaccine

    acceptance was less stark across the subscales of vaccines have a positive value (5.4 vs. 4.6),

    vaccines are effective (5.1 vs. 4.2), and acceptance of selection and scheduling of vaccines (5.1

    vs. 4.3).

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Safety Effect Accept Value Legit

    Figure 18 Vaccine Accpetance by Regularly Wears Mask

    Yes No

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Safety Effect Accept Value Legit

    Figure 17 Vaccine Acceptance by Chance of Getting Coronavirus

    No chance Any chance

  • 22

    Next, we examined if

    respondents believe masks

    helped stop the spread of

    the coronavirus. Overall, if

    the respondent believes

    wearing masks helps stop

    the spread of the virus, the

    total vaccine acceptance

    measure was higher, 5.2,

    than if the respondent does

    not believe masks help

    stop viral transmission,

    4.5. Large differences were

    found for perceived safety

    (4.9 vs. 4.0) and legitimacy

    of government to require

    vaccines (5.2 vs. 4.3). Positive value of the vaccine had the highest values (5.4 vs. 5.0) with the

    smallest difference. Both effectiveness of the vaccine (5.2 vs.4.5) and acceptance of selection

    and scheduling the vaccine (5.2 vs. 4.7) showed large mean differences.

    Finally, we assessed if respondents believed the state order to wear a mask was needed was

    related to vaccine acceptance. As Figure 20 shows, the difference in mean scores was not large.

    Those who felt a state order was needed had a mean score of 5.1 compared to those who felt it

    was not needed, 4.8.

    The mean difference

    across the vaccine

    acceptance subscale

    was largest for

    legitimacy of

    government to

    require vaccines (5.1

    vs. 4.6) and smallest

    for the belief that

    vaccines have a

    positive value (5.4 vs.

    5.2). Perceived safety

    of the vaccine was

    low for those who felt

    the order was

    warranted (4.8) and those who felt it was not warranted (4.4). For vaccine effectiveness (5.1 vs.

    4.8) and acceptance of the scheduling of vaccines (5.2 vs. 4.9) the results were similar to the

    overall vaccine acceptance scale scores.

    Social Gathering. Several questions in the Pandemic Poll ask about social gatherings. One

    asks about whether a respondent agrees or disagrees with the decision to allow large social

    gatherings. A second question asks the respondent if he/she attended church, temple or other

    religious event in person in the past two weeks.

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Safety Effect Accept Value Legit

    Figure 19 Vaccine Acceptance by Masks Helps Stop the Spread of

    the Coronavirus

    Yes No

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Safety Effect Accept Value Legit

    Figure 20 Vaccince Acceptance by Statewide Mask order Needed

    Yes No

  • 23

    As shown in Figure 21, the mean difference on the vaccine acceptance scale and subscales

    between those who believe large gatherings should be allowed and those who do not are small

    (5.1 vs. 4.8). Furthermore, there was no real mean difference between the groups on the subscale

    measuring the value

    of vaccines.

    Generally, if a

    person agreed with

    the decision to

    allow large group

    gatherings, they

    were less likely to

    accept vaccines

    than those who

    disagree with the

    decision to allow

    large gatherings.

    As shown in

    Figure 22, there

    were small

    differences in the

    overall measure of

    vaccine acceptance

    by the measure of

    church attendance,

    4.8 vs. 5.1. And,

    differences were

    small across all the

    sub-scales. Overall,

    greater church

    attendance was

    associated with

    lower vaccine

    acceptance, but the

    difference was not

    large.

    Summary. As Arkansas works towards developing a COVID-19 vaccination program, it is

    important to understand variation in vaccine acceptance across the state. We used a valid and

    reliable tool designed to assess vaccine acceptance in the general population. The tool was

    designed to assess multiple components of vaccine acceptance. Essentially, the measure assumes

    a person’s decision to accept a vaccine is the product of an evaluation of vaccine safety,

    effectiveness, scheduling, beliefs about the positive value the vaccine has for self and society,

    and legitimacy of the government to require vaccines. We found important differences for

    vaccine acceptance and its subscale components by race/ethnicity and beliefs about pandemic

    mitigation efforts. Asking a simple question about taking a COVID-19 vaccine misses important

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Safety Effect Accept Value Legit

    Figure 21 Vaccince Acceptance and Agree with Decision to Allow Large

    Social Gatherings

    Agree Disagree

    3

    3.5

    4

    4.5

    5

    5.5

    6

    Total Safety Effect Accept Value Legit

    Figure 22 Vaccine Accpetance by Whether Attended Church, Temple of

    Other Religious Gathering in person in Past Two Weeks

    Yes No

  • 24

    opportunities to target different approaches to different groups to improve vaccine acceptance.

    What is clear is: Blacks have lower vaccine acceptance than Hispanics and Whites and

    differences may center on perceived vaccine safety. It is also clear that the more a person agrees

    with and practices COVID-19 mitigation practices, the more likely he/she is to accept a vaccine.

  • 25

    Methodological Notes

    Short-term forecasts. Time series forecasting is a method that uses observed data to predict

    future values. The purpose of the models is to fit the best curve to data and extend the curve into

    the future. To forecast aspects of the pandemic in Arkansans, the models used COVID-19 cases,

    hospitalizations, ICU admissions, and death data reported to the Arkansas Department of Health.

    It should be noted the report defines a “case” as a COVID-19 test result reported and posted by

    the Department of Health. As indicated by recent research, the number of undiagnosed COVID-

    19 infections in the community may be higher by 40 to 50%. We cannot provide a precise

    number of undiagnosed infections in the community, as an antibody seroprevalence study has not

    yet been completed in the state.

    Mid-term Projections. The SEIR model projects COVID-19 cases and deaths using the

    same basic parameters — susceptible (S), exposed (E), infected (I), and recovered (R), that have

    been widely used to model epidemics since the 1920s. In addition, SEIR models account for the

    changing social conditions, such as the face mask order and opening schools, changing infection

    probabilities, and symptomatic and asymptomatic spread of cases. To arrive at the best model fit

    for mid-term projections of COVID-19, we first used a SEIR model (Exposed (E)) to model

    existing cases. The resulting fit was very good, but required a second step to project cases out to

    predicted date. The difficulty with SEIR-like models is that actual COVID-19 cases may not

    accurately represent viral spread. This can occur for a number of reasons, including variation in

    rates of testing and limited knowledge of the contribution of asymptomatic infections to viral

    spread. To extend our SEIR model projections, we calculated a seven-day rolling average model

    using the number of cases to date. Results between the SEIR and seven-day rolling average

    estimates were consistent, with a fit coefficient above 75%.

    Long-term projections. The eSIR model is based on the extended state-space SIR (eSIR)

    model. A standard SIR model has three components: susceptible (S), infected (I), and removed

    (R), including both recoveries and deaths. The proportion of the population falling into each

    mutually exclusive category is assumed to vary over time, creating the standard epidemic curve.

    The model creates projections of active infections, including mild and asymptomatic infections,

    over time. Active infections are not cumulative infections from the beginning of the pandemic,

    nor are they restricted to new cases on a given day. Rather, the model estimates the proportion of

    the population with an unresolved infection at a given point in time.

    Changing model assumptions and their impact on projections. Since the last report, the

    model’s assumption regarding the likelihood of transmission has been adjusted slightly upward

    to better match Arkansas data. The model was also extended an additional six months into the

    future to better observe the predicted post-peak dynamics. The eSIR model was originally

    developed using assumptions based on data from China, such as the R0 estimate. R0 (pronounced

    R-naught) is a measure of how many people one infected person can infect. The model learns

    and improves over time by adjusting internal assumptions as more Arkansas-specific data

    become available. For example, the R0 changed in the model over time from 3.15 to 1.39. Earlier

    versions of the model, working with less Arkansas data, relied more heavily on the assumptions

    derived from Chinese studies. Consequently, in the beginning, the model predicted a more

    aggressive epidemic than we have observed in Arkansas. As more Arkansas data have become

    available, the model has adjusted itself to better reflect the more extended epidemic curve we

    now observe.

  • 26

    Comparison to other models. Curve fitting models, like the widely cited University of

    Washington IHME model, tend to make strong assumptions, which are unlikely to hold as more

    data become available. In addition, curve fitting models cannot account for epidemic dynamics.

    This often results in severe reductions in predictive strength beyond short-term windows.

    SIR/eSIR models, like we use in this report, have a stronger theoretical basis for long-term

    projections. Regarding the eSIR model’s relatively late date for a peak, this is in line with other

    long-term projection models, such as the CIDRAP Viewpoint, which predicts the COVID-19

    pandemic will last 18 to 24 months. Furthermore, reports from week to week cannot be

    compared to each other. As more data are added to a model, differences reflect new Arkansas-

    specific data. Therefore, the results reported above should not be compared to the previous

    reports. However, the eSIR model may be suggesting the COVID-19 growth curve may be

    leveling off.

    Arkansas Pandemic Poll. One the challenges of looking at responses by race/ethnicity is

    that some racial/ethnic groups in the poll have too few numbers to be included in the analyses.

    For example, we do not have enough respondents who are Marshallese to include them in the

    analyses. However, the Marshallese are an important racial/ethnic group in the state with respect

    to the COVID-19 pandemic.

    The percentage of individuals who felt that they have a low chance of getting infected in the

    last two weeks. Response categories vary from 1 (no chance) to 5 (high chance). Responses 1, 2,

    and 3 were recoded as low chance and 4 and 5 are recoded as high chance of contracting

    COVID-19.

    Vaccine Acceptance Measure

    Original source: A survey instrument for measuring vaccine acceptance. Sarathchandra, D,

    Navin. C, Largent, M, McCright, A. Preventive Medicine 109:1-7, 2020.

    Instructions for the interviewer to read to the respondent. The following questions ask your

    views on vaccines particularly potential COVID-19 vaccines. Please indicate how much you

    agree or disagree with the following. Interviewer, read response categories following each

    question. (Note the underlined text in the instructions is the only change from the original

    instrument.) The response categories are: strongly disagree, moderately disagree, slightly

    disagree, I am not sure, slightly agree, moderately agree, strongly agree. The questions are :

    vaccines are safe; vaccines contain dangerous ingredients; some vaccines are unnecessary since

    they target relatively harmless diseases; vaccines are effective in preventing diseases; we give

    children the right number of vaccines; we give children too many vaccines, vaccines conflict

    with my beliefs that children should use natural products and avoid toxins; vaccines are a major

    advance for humanity; the government should not force children to get vaccinated to attend

    school; to protect public health, we should follow government guidelines about vaccines.

    The overall vaccine acceptance scale is the sum of 10 items. Subscales are the following

    sums: 1&2 perceived safety of vaccines; 3&4 perceived effectiveness and necessity of vaccines;

    5&6 acceptance of vaccine selection and scheduling; 7&8 perceives the value of vaccines; 9&10

    perceived legitimacy of authorities to require vaccinations.

    The Cronbach’s alpha for overall scale is 0.83.

  • 27

    Glossary of Terms

    Active infection = a positive infection, with or without a COVID-19 test, that has not yet

    recovered or died

    Case = a positive COVID-19 test result reported to the Arkansas Department of Health

    Community = population not in a prison or population not in a prison or nursing home

    Cumulative = total number of a given outcome (e.g., cases) up to date

    Extended state-space SIR (eSIR) model = a model based on three components: susceptible

    (S), infected (I), and removed (R, including both recoveries and deaths)

    Susceptible-Exposed-Infected-Recovered model (SEIR) = another variant of standard

    epidemiological model considering exposure as another factor controlling for disease dynamics

    Hospitalization = a positive infection or case that was admitted to the hospital

    ICU = intensive care unit admission

    Infection = a COVID-19 infection, with or without a test and regardless of having recovered

    or died

    Non-incarcerated (NI) = representative of an individual who is not in a jail or in a

    correctional facility

    Positivity Rate = The number of people who test positive for covid-19 as a proportion of

    people have been tested

    Projections = long-term predictions

    Recovered = a positive infection that is no longer symptomatic or shedding virus

    Susceptible = an individual who can be infected with the disease of interest

    Time series forecast = short-term forecast of events through a sequence of time