The Future of Flow Chemistry

asiafast, clean, safeflow chemistry

asia Asia is a revolutionary range of award-winning flow chemistry

products from Syrris. It has been designed by chemists for

chemists to enable the widest variety of chemical reactions and

ultimate ease of use.

The proprietary technology allows manually controlled or

fully automated experiments. Asia offers maximum chemical

resistance with an extensive range of temperatures, pressures,

and reaction times on scales from mg to kg.

Watch Asia videos at: www.syrris.com/videos

Asia Specifications

• Reactor temperature: -100°C to +250°C

• Liquid phase reactor volumes: 6.25μl, 62.5μl, 250μl, 1ml, 4ml, 16ml

• Solid phase reactor volumes: 0.7ml, 2.4ml, 5.6ml, 12ml

• Pressure: 0 to 20bar (300psi)

• Flow rate: 1μl/min to 10ml/min per pump channel

• Residence times: 1 second to multi hour

• Wetted materials: Glass, PTFE and PCTFE (stainless steel and hastelloy possible)

• Mixing: Rapid diffusion mixing

• Production volumes: micrograms to kilograms

• Perform a wider range of

chemistries

• Flexible to meet chemist needs (and

budget)

• Integration of synthesis, work-up and

analysis

• Safer and cleaner reactions

• More reactions in less time

• Maximum chemical resistance

• Ideal for synthesis, rapid optimization

and scale-up

• Robust and easy to use

Benefits

Learn about

flow chemistry benefits,

applications and

gain hands-on experience!

Worldwide locations.

Find out more:

www.syrris.com/news/

chemistry-workshops

Join our Free 1-Day Flow Chemistry Workshops

asia Asia is a revolutionary range of award winning flow

chemistry products from Syrris.

It has been designed by chemists for chemists to

enable the widest variety of chemical reactions and

ultimate ease of use. The proprietary technology allows

automated experiments with or without a PC. Asia

offers maximum chemical resistance with an extensive

range of temperatures, pressures, and reaction times

on scales from mg to kg.

systems

Asia is a modular range of flow chemistry systems, available in either regular or

advanced configurations for both beginners with modest budgets and experts

who demand the utmost functionality. The unique benefits of flow chemistry

make it a suitable tool for a wide range of applications. Syrris has pre-configured

systems for specific applications:

• Asia Starter Systems: affordable, ideal for beginners or education, easy to upgrade

• Asia Cold Systems: safe chemical reactions under cryogenic conditions

• Asia Electrochemistry Systems: easy access to flow electrochemical reactions

• Asia Discovery Chemistry Systems: ideal for limited quantities of starting material or handling of expensive reagents

• Asia Process Optimization Systems: ideal for converting batch reactions to flow processes. Reaction parameters can easily be varied for optimization

• Asia Nanoparticle Systems: reliable production of nanoparticles

• Asia Scale-up Systems: ideal for running test reactions on few mgs scale before increasing the manufactured amount up to a kg/day on the same system with minimal setup changes

• Asia Premium Systems: utmost functionality and access to the widest range of chemical space

Asia Features and Benefits

Asia Chip Climate ControllerEnables glass microreactors to be cooled or heated from -15°C to +150°C - no need for circulator or cold water supply.

Asia Reagent Injector2 extremely chemically resistant injection valves with sample loops. 0.1ml, 1ml, 5ml or 10ml, manual or automated control, 0 to 20 bar.

Asia Manager SoftwareEasy to use for total ‘walk-away’ control of the Asia System.

Asia Syringe PumpExtremely chemically resistant continuous flow pumps for ultra smooth flow. Flow rate from 1μl/min to 10ml/min each, 20 bar, pressure sensor.

Asia Pressurized Input Store Pressurizes four bottles with an inert gas enabling the use of air sensitive reagents and eliminates bubble formation when pumping. Input pressure 1-10 bar, output pressure 1 bar.

Asia Automator: Connect all modules to the Automator for PC Software control of all modules to automate reactions.

Asia Flux - Flow ElectrochemistryEnables a wide range of electrode materials to be changed in seconds. No tools. Includes a power supply and electrochemical flow cell with minimal electrode gap. Internal reaction volume 225µl.

Asia Pressure ControllerAutomatically pressurizes the reaction up to 20bar (300psi) for ultra-fast reaction rates.

Asia Sampler and DilutorEnables on-line reaction analysis by automated sample extraction, dilution and transfer to an analytical system e.g. LCMS or UPLC. Dilution factor: 5 to 250.

Asia FLLEXThe Flow Liquid Liquid EXtraction (FLLEX) offers continuous flow aqueous work up. Internal volume 100µl.

Asia Heater and ChipThis module has adaptors that can be changed in seconds to heat reactors. Temperature range from room temperature to 250°C.

Glass Microreactor 62.5µl, 250µl or 1ml. Max temp: +250°C

Tube Reactor: 4ml or 16 ml. Ideal for scale-up. Max temp: +250°C

Asia Solid Phase Reactor 0.7ml, 2.4ml, 5.6ml, 12ml. Max temp: +150°C

Asia Automated CollectorAllows collection of multiple reactions in separate vials or vessels. Waste is automatically diverted.

Asia Product Collector: enables waste to be diverted and can be used to automatically collect one reaction product, or manually collect many samples.

Asia Cryo ControllerRapidly cool a selection of fluoropolymer or stainless steel tube reactors to -70°C or a range of glass or quartz microreactors to -100°C. No tools, mains power only, cool down to -100°C.

Asia Tube Cooler (alternative):Cool Asia Tube Reactors to -68°C. Use as standalone or plug into an Asia Heater to have the reaction temperature monitored and displayed.

Asia Premium Advanced System

Asia Automated Reagent InjectorIncludes two independent chemically resistant channels allowing reagents stored in racks of septum capped vials to be automatically aspirated and loaded into injection loops.

Asia Cold Systems

The Asia Cold Systems have been specially defined to enable safe chemical reactions under cryogenic conditions (e.g. exothermic organometallic reactions).

The systems incorporate all the required parts for running reactions in continuous flow at temperatures down to -100°C. The Regular system uses a Tube Cooler with dry ice and acetone. The Advanced system centres on the Cryo Controller, an innovative and unique module able to cool down to -100°C using electric power only without the need for external cooling.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar‡

System temperature -68°C to ambient -100°C to +250°C

Pump channels 2 4

Chip Reactors Tube Reactors

Column Reactors Product collection manual automated

Pressurized inputs Injection valves 2 4

Automation

† Depending on the syringe size. ‡10 bar when using fluoropolymer tube reactors. Depending on cooling solution.

Asia Starter Systems

The Asia Starter Systems are ideal for chemists eager to begin using flow chemistry as well as academics interested in introducing flow chemistry to their group.

The easy-to-use and affordable systems contain all essential flow system parts: an Asia pump, an Asia Chip Climate Controller, a glass microreactor and an Asia Pressure Controller. The systems are future-proof and can be seamlessly upgraded with additional features and modules as the user experience with flow chemistry grows.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar 0 to 20bar‡

System temperature -15°C to +150°C -15°C to +250°C

Pump channels 2

Chip Reactors Tube Reactors

Column Reactors Product collection manual

Pressurized inputs Injection valves 2

-100°CAffordable, easy to

upgrade!

Asia Discovery Chemistry Systems

For limited quantities of starting material or expensive reagents, Asia Discovery Chemistry Systems offer setups capable of running flow experiments using very small amounts of reagents.

Users can design a list of experiments, each requiring just hundreds of microliters of reagents, and run them in sequence. Using a range of modules, the system will automatically inject the required amount for each reaction and collect the resulting solution in a small vial.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar 0 to 20bar‡

System temperature -15°C to +150°C -100°C to +250°C

Pump channels 2 4

Chip Reactors Tube Reactors

Column Reactors Product collection automated automated

Aqueous work-up Pressurized inputs

Injection valves 2 4

Auto injection valves 2

Automation

†Depending on the syringe size. ‡ 10 bar when using fluoropolymer tube reactors.

Asia Electrochemistry Systems

Electrochemical activation of chemical reagents enables selectivity and transformations impossible by other techniques. The Asia Electrochemistry Systems give easy access to electrochemical reactions in continuous flow.

The Asia Flux module and cell can accommodate a wide range of electrodes, assembled without the need for tools, and users can operate in either constant current (Galvanostatic) mode or constant voltage (Potentiostatic) mode to achieve reductions and oxidations.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 5bar

System temperature 0°C to +60°C

Pump channels 2 4

Chip Reactors Tube Reactors

Column Reactors Electrochemistry Flow cell volume 225µl 225µl

Product collection manual automated

Pressurized inputs Injection valves 2 4

Automation

Easy electrochemical reactions in flow!

For limited quantities of material

Asia Nanoparticle Systems

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar‡

System temperature +45°C to +250°C -15°C to +250°C

Pump channels 2 4

Chip Reactors Tube Reactors

Product collection manual automated

Pressurized inputs Injection valves 4

Automation

Asia Process Optimization Systems

Ideal for converting a batch reaction to a flow process and varying reaction parameters to optimize it.

Easy setup of tens of automated reactions using the intuitive Asia Manager Software. The systems will calculate the required flow rates and reagent amounts and fully automate each reaction. Risk prevention features such as automatic shutdown in case of detected blockage ensure maximum safety is maintained during the run. The systems can be expanded with capabilities such as electrochemistry.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar‡

System temperature -15°C to +250°C

Pump channels 2 4

Chip Reactors Tube Reactors

Column Reactors Product collection automated automated

Aqueous work-up Pressurized inputs

Injection valves 4

Auto injection valves 2

Automation

†Depending on the syringe size. ‡ 10 bar when using fluoropolymer tube reactors.

Narrowparticle sizedistribution

Automated reaction

optimization

Asia Scale-up Systems

Flow chemistry offers an easy way for scaling up reactions.

Flow reaction parameters can be optimized using a small microreactor on few milligrams before moving onto a large tube reactor system for synthesizing multi-gram quantities of products. The systems enable exploratory reactions to be performed and optimized on a few mgs scale. The manufactured amount can then be increased to kgs per day on the same system, with minimal setup changes.

Asia Premium Systems

Ideal for chemists who are interested in the utmost functionality and access to the widest range of chemical space.

The Asia Premium Systems offer a full range of Asia modules and enable standard flow chemistry operations (reaction optimization, scale-up, etc.) as well as advanced use (electrochemistry, multi-step reactions, cryogenic reactions, etc.). These exhaustive systems include the benefits of all the other systems.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar‡

System temperature -100°C to +250°C

Pump channels 4 6

Chip Reactors Tube Reactors

Column Reactors Electrochemistry

Product collection automated automated

Aqueous work-up Pressurized inputs

Injection valves 4 4

Auto injection valves 2

Analysis interface Automation †Depending on the syringe size. ‡ 10 bar when using fluoropolymer tube reactors. Depending on cooling solution.

Regular Advanced

Flow rate 1.0µl/min to 10ml/min†

Pressure 0 to 20bar‡

System temperature -68°C to +250°C -100°C to +250°C

Pump channels 2 4

Tube Reactors Column Reactors

Aqueous work-up Pressurized inputs Analysis interface

Automation

Utmost functionality for widest range of

chemistry!

4ml or 16ml tube

reactor for scale-up

Flow chemistry offers exceptional advantages for nanoparticle synthesis which result in narrow particle size distribution and control over shape and architecture.

The systems offer fast and reproducible mixing, excellent heat transfer and accurate temperature control.

The systems are ideal for rapid optimization and production of nanoparticle synthesis.

Testimonials

“We chose the Asia flow chemistry system

because of its ability to provide options for

mini-reactor, mini-column reactor and

micro-reactor set-ups in a single platform:

this level of flexibility is unique to the Asia

products. ” Florin Oancea, Scientific

Director at ICECHIM

“The modular design of the Asia system is very helpful,

allowing us to rearrange it into different configurations

to suit whatever multi-step synthesis sequence we need

to perform. The flexibility to change syringes enables

anything from very small scale to large scale synthesis to

be achieved.” Catherine Carter, Ley Group, University

of Cambridge, UK

“The system is running seven days a week, and is so

popular that people are queuing up to use it. The Asia

system helped us to become the first group at the

University – and in Brazil – to develop biocatalyzed

continuous flow reaction. It is a very user-friendly system,

and the wide range of flow rates offered by the Asia Pump

is a big advantage. We also have the capability to load the

solid phase column reactors with our own catalysts, which

is another great benefit.” Dr Rodrigo Souza, Associate

Professor in Organic Chemistry, UFRJ, Brazil

For more testimonials, visit: www.syrris.com/company/testimonials

Asia Starter

Systems

Asia Cold

Systems

Asia Electro-

chemistrySystems

Asia DiscoverySystems

Asia Process Optimi-zation

Systems

Asia Nano-

particleSystems

Asia Scale-UpSystems

Asia PremiumSystems

reg adv reg adv reg adv reg adv reg adv reg adv reg adv reg adv

Pressurized Input Store • • • • • • • • • • • • • • 2Pump (2 Channels) • • • 2 • 2 • 2 • 2 • 2 • 2 2 3Reagent Injector (2 Channels) • • 2 • 2 • 2 2 2 2 2Automated Reagent Injector • • •Chip Climate Controller • • • • • • • • • • •Heater • • • • • • • 2 • 2 • •Heater Chip Adaptor • • • • • • • 2 • •Heater Column Adaptor • • • • • • • • • •Heater Tube Adaptor • • • • • • • 2 • 2 • •Tube Cooler • •Cryo Controller • • • • •FLUX • • • •Pressure Controller • • • • • • • • • • • • • • •FLLEX • • • • •Asia Sampler and Dilutor • • • •Product Collector • • • •Automated Collector • • • • • • • • •Automator 2 2 • 2 • 2 • • 2 3Asia Manager PC Software • • • • • • • • • •

standard option•

Asia Systems - Configuration

All systems are available as either regular or advanced configurations to suit

different requirements and budgets. All systems include a common module – the

Asia Pump. This is the most advanced and sophisticated flow chemistry pump

available. Please see below which modules are included in each system.

Asia is designed and manufactured by Syrris, the world’s longest established provider of laboratory scale

flow chemistry systems.

Asia has received an R&D 100 Award, this recognizes Asia’s advanced functionalities, ease of use and applicability to an extremely

wide range of chemistries.

Syrris’ network of offices in the UK, USA, Japan, India and Brazil plus over 35 distributors worldwide offer local service and support.

Contact us now at:www.syrris.com

Syrris is a brand of Blacktrace Holdings Ltd