ESTIMATION OF PLACENTA FUNCTION USING T2* MEASUREMENTS DURING HYPER- AND NORMOXIA

May 9th, 12 am, Computer no 73

Mother + O2 maskMother w/o mask

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40 50 60 70 80 90

ESTIMATION OF PLACENTA FUNCTION USING T2* MEASUREMENTS DURING

HYPER- AND NORMOXIA

4142

• David Alberg Peters • Department of Clinical Engineering, Central Denmark Region, Aarhus,

Denmark• David.Peters@stab.rm.dk

• Anne Sørensen• Department of Obstetrics and Gynecology, Aarhus University, Aalborg

Hospital, Denmark

• Torben Fründ• Department of Radiology, Aarhus University, Aalborg Hospital,

Denmark

• Ole Bjarne Christiansen• Department of Obstetrics and Gynecology, Aarhus University, Aalborg

Hospital, Denmark

• Niels Uldbjerg• Department of Obstetrics and Gynecology, Aarhus University

Hospital, Denmark.

May 9th, 12 am, Computer no 73

Materials

6 x g.w.28-35

MATLAB

Protocol

Loca

lizer

Mult

i Ech

o

GE

10 min

Mult

i Ech

o

GEBold

im

ag

ing

(sep

ara

te

stu

dy)

Multi Echo GE TR=70.9ms, TE=3.02 to 67.5 ms – step 4.3

ms. FOV 350x350 mm, Matrix 256 x 128, Three 8

mm slices

Normoxia (21% O2) Hyperoxia (100% O2)

Acquisition

Multi Echo GE sequence - Increasing TE

Placenta ROI

Processing

T2* fitted (Levenberg Marquardt implemented in MATLAB)

Fitted either Pixel by pixel or in a region of interest (ROI)

Results (ROI based fitting)

Subject 1

Subject 2

Subject 3

Subject 4-5-6

Mean change (P<0.01)

Results (Pixel by pixel fitting)

0 10 20 30 100

40 50 60 70 80 90

Normoxic Hyperoxic

T2* (ms)

Conclusion

T2* increases significantly in the placenta when the mother breathes oxygen

The change in T2* is inhomogeneously distributed in the placenta

The change in T2* is most likely caused by a change in the pO2 of the blood in placenta

Placenta structure

Fetal placenta

Maternal placenta

Discussion

Correspondance between “blue” areas in pre oxygen T2* map and fetal side of

placenta?

Same?

Same?

Discussion

Is the difference between hyperoxic and normoxic placenta T2* value an indicator of placenta function?

Is a reduced response sign of a poorly functioning placenta?