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ADRENOCORTICAL

HORMONES

AQSA SJUHADADepartment of Oral Biology

Faculty of Dentistry Airlangga University

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Hyperaldosteronemia

Renal Disorder

Disfunction of renal excretion

SEVERE HYPERTENSION

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HIGH LEVEL OF ALDOSTERON

OCCURRED ON:1. ECF K ion level2. Na ion

3. Renin-Angiotensin System- Angiotensin II >>

Aldosteron >>4. ACTH

ACTH

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STRESS

Stress (physic neurogenic)

ACTH

Cortisol

Protein and fat mobilization

Energy

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REGULATION OF CORTISOL

HypothalamusACTH-RH

Anterior hypophysisACTH

Adrenal cortex

Circadian rhythm:

ACTH-RH, ACTH and cortisol secretion- High in the morning- Low in the evening - night

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ABNORMALITIES

1. HYPOADRENALISM(Addison disease)- failure of cortex adrenalis- Aldost

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2. HYPERADRENALISM

(Cushing Disease)- adrenal cortex hypersecretion- Cortisol >>>

- Androgen >>>, masculinizing effect ,acne.- Fat mobilization, Buffalo torso - Steroid >>, face edema,

moon face - Plasma glucose >>, Adrenal Diabetes,Diabetes Mellitus