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EMF and Biological Effects: Proposed Mechanisms EFFECTS ON MOLECULAR BONDS EFFECTS IN GENE FUNCTION AND STRUCTURE EFFECTS ON SPECIFIC SUBCELLULAR ELEMENTS EFFECTS AT LEVEL OF MEMBRANE GROUP CELL BEHAVIOR ELECTRICAL EFFECTS ON CELLS, SYNAPSES PULSED, MAGNETIC EFFECTS ON CELLS, SYNAPSES EFFECTS ON PROTEINS, HORMONES AND NEUROTRANSMITTERS SPECIES EFFECTS, TROPHIC CASCADE EFFECTS, LOSS OF BIODIVERSITY "N o kno wn mec hanism" -- "So What?" BREAKAGE, OXIDATION MW/RF , MDA, brain Oxidative DNA damage NOS relationship ef fects Oxidative mechansims of RF ELF-EMF , oxidative stress, cell death LIVING ANTENNAS, ARTIFICIAL EMF GENETIC FUNCTIONAL CHANGES, DAMAGE FREE RADICAL DAMAGE, NUTRIENT DEPLETION DNA as a fractal antenna HAARP interference with bee homing Up and down-regulation of genes Heroux Unified Theory , DNA and MF Oxidation and antioxidant depletion Osmolarity af fects threshold field ef fects T riage nutrients diverted, stress response MAGNETIC FIELD EFFECT ON MAGNETITE EMF, INTERFACIAL WATER CHANGES TO CRYPTOCHROME MOLECULE ATP FORMATION AND MAGNETIC SPIN MITOCHONDRIA, COHERENCE ALTERATION Magnetite in human tissues ELF and biologic magnetite Cell death, ferromagnetic transduction Overview: Susak et al Overview: Ramazzini Institute Ef fect on A TPS due to water ef fect Living Rainbow H20, Mae-W an Ho Intracellular water dynames and NIR Cryptochromes EMF Cryptochrome mediates magnetosensitivity Ion-radical process, magnetic moment EM field disturbance of mitochondria BLOOD FLOW, VESSEL DAMAGE STATIC MAGNETIC FIELD PLUS EMF PUSHING MOLECULES CALCIUM EFFLUX, MEMBRANE/RECEPTOR EFFECTS INTRODUCTION OF "NOISE" MEMBRANE PORATION Disrupted cerebral blood flow Albumin leakage, barrier breech Induction of cyclotron resonance Calcium ion, cyclotron resonance, MF RF , receptor clustering Rouleau formation, MW Ion channel transduction Calcium channels, apoptosis Membrane nanopore formation Activation voltage gated calcium channels EM Biocompatibility: Compensatory Magnetic Oscillation Induction of stochastic resonance Stochastic resonance, voltage-gated channels, EMF Electroporation THERMOELASTIC WAVE EFFECT ORGAN AND TISSUE FUNCTION INTERFERENCE WITH NEURONAL OSCILLATIONS Microwave auditory ef fect Thermoelastic theory , MW MW , heart rate variability Decrease in band coherence Appearance of EEG slow waves More anterior alpha, less posterior Neuronal network firing/burst rate changes INDUCED E CURRENTS, INCREASED BODY VOLTAGE DISRUPTION, ENDOGENOUS EM OSCILLATIONS CHANGES IN POLARIZATION, SYNAPSES DENSITY OF PHOTONS EFFECT Electric currents, A.L.S. Body voltage information T ransients, BV , phys-ion movement EM interaction and well-being Electrical fields, polarization of neurons Gap junction changes, tumor promotion Plarization, dif ference natural/unnatural V oltage transients interfere with gap junctions High photon density , dielectric ef fect of MW Bioelectric phenomena and photon aggregation EFFECT ON NON-EXCITABLE CELLS PEMF mechanisms Possible novel mechanisms of AM ALTERATION OF MATRIX DEFICIENCY OF NATURAL EMF HEAT SHOCK PROTEINS DENATURATION OF PROTEINS CIRCADIAN RHYTHM EFFECTS Melatonin hypothesis Increased beta-amyloid Increased production, release, histamine Digital stress,global EM toxicity Stress protein synthesis Hsp70, mobile phone stress marker ELF , protein proton relaxation EMF and the folding of egg protein Chrononodisruptive ef fects Alteration of blood characteristics Power lines and nocturnal melatonin EFFECTS ON BEES, POLLINATORS EFFECTS ON TREES, OTHER PLANTS Barrie T rower , Bees, 2010 Massive destruction of nature by EMF EMF and T ree Damage ELF , pea roots, calcium disruption RF , tomato plants, stress response, mRNA HOW DO ARTIFICIAL NON-IONIZING ELECTROMAGNETIC FIELDS INTERFERE WITH BIOLOGICAL TISSUE FUNCTIONS AND STRUCTURES? MANY MECHANISMS HAVE BEEN PROPOSED. THEY ARE NOT EXCLUSIVE OF EACH OTHER. THEY ARE NOT EQUALLY WELL STUDIED OR SUPPORTED. SOME OF THE EFFECTS ARE MORE UPSTREAM PHYSIOLOGICALLY, AND THEREFORE CAUSE OTHERS. THE EFFECTS ON ANY GIVEN INDIVIDUAL DEPEND UPON THE TYPE OF EXPOSURE AS WELL AS THE SPECIES, GENDER, HEALTH, AGE OR TISSUE(S) INVOLVED. MECHANISMS DIFFER FROM SIGNS OF PATHOLOGY OR SYMPTOMS OF ILLNESS; RATHER, THEY EXPLAIN HOW SIGNS AND SYMPTOMS ARE INITIATED. Home: Oscillatorium Newest version this map Date of this update: 11-25-15 CELLULAR FUNCTIONS AND BEHAVIORS Orientation of magnetite "Switching" of cryptochrome molecule Enzyme functions, methionine synthase Gene expression, stress proteins, apoptosis Clumping of some cells, movements of others CELLULAR STRUCTURES Molecular bonds of DNA, RNA Alterations in ATP production, different mechanisms Membranes, cellular, subcellular Resonance changes within fluid compartments Receptors/channels within membranes Concentrations of ions, molecules, nutrients TISSUE EFFECTS Decreased integrity of blood-brain barrier Brain dysfunction: brainwaves, sensory disturbance Brain developmental issues: autism Brain structural changes, beta-amyloid, tumors Brain function, cognitive effects, abnormal proteins Circadian changes in hormonal releases Cardiovascular rhythm changes Immune response alterations CASCADING MECHANISMS MOLECULAR TO MULTI-SPECIES Free radical cascades Calcium influx and cellular activity Field reorientation of ions, cells Single species gene pool disruptions Multi-species trophic cascade

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EMFand

Biological Effects:Proposed Mechanisms

EFFECTS ON MOLECULAR BONDS

EFFECTS IN GENE FUNCTION AND STRUCTURE

EFFECTS ON SPECIFIC SUBCELLULAR ELEMENTS

EFFECTS AT LEVEL OF MEMBRANE

GROUP CELL BEHAVIOR

ELECTRICAL EFFECTS ON CELLS, SYNAPSES

PULSED, MAGNETIC EFFECTS ON CELLS, SYNAPSES

EFFECTS ON PROTEINS, HORMONES AND NEUROTRANSMITTERS

SPECIES EFFECTS, TROPHIC CASCADE EFFECTS, LOSS OF BIODIVERSITY

"No known mechanism" -- "So What?"

BREAKAGE, OXIDATION MW/RF, MDA, brain

Oxidative DNA damage

NOS relationship effects

Oxidative mechansims of RF

ELF-EMF, oxidative stress, cell death

LIVING ANTENNAS, ARTIFICIAL EMF

GENETIC FUNCTIONALCHANGES, DAMAGE

FREE RADICAL DAMAGE, NUTRIENT DEPLETION

DNA as a fractal antenna

HAARP interference with bee homing

Up and down-regulation of genes

Heroux Unified Theory, DNA and MF

Oxidation and antioxidant depletion

Osmolarity affects threshold field effects

Triage nutrients diverted, stress response

MAGNETIC FIELD EFFECT ON MAGNETITE

EMF, INTERFACIAL WATER

CHANGES TO CRYPTOCHROME MOLECULE

ATP FORMATION AND MAGNETIC SPIN

MITOCHONDRIA, COHERENCE ALTERATION

Magnetite in human tissues

ELF and biologic magnetite

Cell death, ferromagnetic transduction

Overview: Susak et al

Overview: Ramazzini Institute

Effect on ATPS due to water effect

Living Rainbow H20, Mae-Wan Ho

Intracellular water dynames and NIR

Cryptochromes EMF

Cryptochrome mediates magnetosensitivity

Ion-radical process, magnetic moment

EM field disturbance of mitochondria

BLOOD FLOW, VESSEL DAMAGE

STATIC MAGNETIC FIELDPLUS EMF PUSHING MOLECULES

CALCIUM EFFLUX,MEMBRANE/RECEPTOR EFFECTS

INTRODUCTION OF "NOISE"

MEMBRANE PORATION

Disrupted cerebral blood flow

Albumin leakage, barrier breech

Induction of cyclotron resonance

Calcium ion, cyclotron resonance, MF

RF, receptor clustering

Rouleau formation, MW

Ion channel transduction

Calcium channels, apoptosis

Membrane nanopore formation

Activation voltage gated calcium channels

EM Biocompatibility: Compensatory Magnetic Oscillation

Induction of stochastic resonance

Stochastic resonance, voltage-gated channels, EMF

Electroporation

THERMOELASTIC WAVE EFFECT

ORGAN AND TISSUE FUNCTION

INTERFERENCE WITH NEURONAL OSCILLATIONS

Microwave auditory effect

Thermoelastic theory, MW

MW, heart rate variability

Decrease in band coherence

Appearance of EEG slow waves

More anterior alpha, less posterior

Neuronal network firing/burst rate changes

INDUCED E CURRENTS,INCREASED BODY VOLTAGE

DISRUPTION, ENDOGENOUS EM OSCILLATIONS

CHANGES INPOLARIZATION, SYNAPSES

DENSITY OF PHOTONS EFFECT

Electric currents, A.L.S.

Body voltage information

Transients, BV, phys-ion movement

EM interaction and well-being

Electrical fields, polarization of neurons

Gap junction changes, tumor promotion

Plarization, difference natural/unnatural

Voltage transients interfere with gap junctions

High photon density, dielectric effect of MW

Bioelectric phenomena and photon aggregation

EFFECT ON NON-EXCITABLE CELLSPEMF mechanisms

Possible novel mechanisms of AM

ALTERATION OF MATRIX

DEFICIENCY OF NATURAL EMF

HEAT SHOCK PROTEINS

DENATURATION OF PROTEINS

CIRCADIAN RHYTHM EFFECTS

Melatonin hypothesis

Increased beta-amyloid

Increased production, release, histamine

Digital stress,global EM toxicity

Stress protein synthesis

Hsp70, mobile phone stress marker

ELF, protein proton relaxation

EMF and the folding of egg protein

Chrononodisruptive effects

Alteration of blood characteristics

Power lines and nocturnal melatonin

EFFECTS ON BEES, POLLINATORS

EFFECTS ON TREES, OTHER PLANTS

Barrie Trower, Bees, 2010

Massive destruction of nature by EMF

EMF and Tree Damage

ELF, pea roots, calcium disruption

RF, tomato plants, stress response, mRNA

HOW DO ARTIFICIAL NON-IONIZING ELECTROMAGNETIC FIELDS INTERFERE WITH BIOLOGICAL TISSUE FUNCTIONS AND STRUCTURES? MANY MECHANISMS HAVE BEEN PROPOSED. THEY ARE NOT EXCLUSIVE OF EACH OTHER. THEY ARE NOT EQUALLY WELL STUDIED OR SUPPORTED. SOME OF THE EFFECTS ARE MORE UPSTREAM PHYSIOLOGICALLY, AND THEREFORE CAUSE OTHERS. THE EFFECTS ON ANY GIVEN INDIVIDUAL DEPEND UPON THE TYPE OF EXPOSURE AS WELL AS THE SPECIES, GENDER, HEALTH, AGE OR TISSUE(S) INVOLVED. MECHANISMS DIFFER FROM SIGNS OF PATHOLOGY OR SYMPTOMS OF ILLNESS; RATHER, THEY EXPLAIN HOW SIGNS AND SYMPTOMS ARE INITIATED.

Home: OscillatoriumNewest version this mapDate of this update: 11-25-15

CELLULAR FUNCTIONS AND BEHAVIORS

Orientation of magnetite"Switching" of cryptochrome molecule

Enzyme functions, methionine synthaseGene expression, stress proteins, apoptosis

Clumping of some cells, movements of others

CELLULAR STRUCTURES

Molecular bonds of DNA, RNAAlterations in ATP production, different mechanisms

Membranes, cellular, subcellularResonance changes within fluid compartments

Receptors/channels within membranesConcentrations of ions, molecules, nutrients

TISSUE EFFECTS

Decreased integrity of blood-brain barrierBrain dysfunction: brainwaves, sensory disturbance

Brain developmental issues: autismBrain structural changes, beta-amyloid, tumors

Brain function, cognitive effects, abnormal proteinsCircadian changes in hormonal releases

Cardiovascular rhythm changesImmune response alterations

CASCADING MECHANISMSMOLECULAR TO MULTI-SPECIES

Free radical cascadesCalcium influx and cellular activity

Field reorientation of ions, cellsSingle species gene pool disruptions

Multi-species trophic cascade