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Italian CRO. Specialized in process development and small scale production.
ELIXENSGROUP
APOLLONSOLAR
French CMO. Specialized in liquidsfor F&F or other applications
LA MESTA
Essential oils & Fragrances Photovoltaïc
EGNO
French CMO. GMP or non GMP synthesis.Specialized in non trivial chemistry.
FLUODY
French family owned company
240 employees50 M€ of Turnover
Equity : 33M€
YRIEL GROUP
Italian CRO. Specialized in process development and small scale production.
ELIXENSGROUP
APOLLONSOLAR
French CMO. Specialized in liquidsfor F&F or other applications
LA MESTA
Essential oils & Fragrances Photovoltaïc
EGNO
French CMO. GMP or non GMP synthesis.Specialized in non trivial chemistry.
FLUODY
Being part of Yriel Group, La Mesta can also offer the synthesis of small quantities of products, impurities, standard reference via its sister company Fluody, an Italian CRO based in Villanova Mondovì (Italia).
La Mesta can also offer the synthesis of highly pure liquids via its other sister company, EGNO Chimie, located in Normandy (France). This company developed a catalog of pheromones and products dedicated to Flavor & Fragrances. On top of that, EGNO works as a CMO for fine chemistry, F&F, …
La Mesta is a CMO We develop the synthesis, industrialize and manufacture sophisticated products used in:
La Mesta offers, as a CMO, the best Quality, Health, Safety and Environmental standards:
ISO 9001 v 2015 certified
Standard Batch Equipment
Proprietary Continuous Flow Reactor : RAPTOR
cGMP certified production plant (ICH Q7A standards) with API sold in Europe, Canada and Japan.
Kosher certification (OU inspection)
FSSC 22000 certification for synthesis of products used in food applications (2018)
Rated Gold by Ecovadis.
FDA registered for flavors supply in the US.
Located in the French Riviera near Nice since 1971, La Mesta Chimie Fine offers the full range of services that you can expect from your chemical partner.
Quality Standards:
Production Technologies:
Pharma: Advanced Intermediates, Starting Materials, Active IngredientsFlavors & FragrancesPhoto IndustryAgrochemicals IntermediatesFine Chemicals
Since 2004, La Mesta has heavily invested in the development of its proprietary Continuous Flow Reactor (RAPTOR). This technology is used at industrial scale to produce different fine chemicals for example in Fragrance, photo or in Pharma (the final step of one API is produced under GMP using this technology).
Example of reactions performed in continuous
Our productions using RAPTOR technology involve different non-trivial chemistry
CONTINUOUS FLOW TECHNOLOGY
Synthesis of 2 MT in 3 weeksCO / Triflic acid 50%
Carbonylation
2 MT -> 317 m3 of CO2 generated and managed in a safe way.
H2O
Decarboxylation
150°C 275°C
High temperature reactions up to 275 °C.
2 MT in 3 weeksCOCl2
Phosgenation
NaHSO3 NaCN RCOCl
Multi steps reaction
In 2017, La Mesta invested in a workshop dedicated to multi-purpose Continuous Flow Production. This equipment allows the synthesis but also the work-up (washing, decantation) to be performed in continuous. Using this fully automatized equipment, La Mesta is able to work with a flow rate of 500 liters per hour, meaning for example the production of 60 MT of the following product in 10 weeks.
MsCl / NEt3
Flow rate: 500 L/h (133 kg/h of product).Production 60 MT in 10 weeks.
This new workshop brings La Mesta among the top players in multi products Continuous Flow Process.
For the synthesis of the above mesylate La Mesta is now able to produce 60 MT in 10 weeks instead of 25 weeks using a 6000 L.
Annual production 60 MT
Equipment used 6000 L vessel 1 L
Duration of production 25 weeks 10 weeks
Productivitysynthesis + washing 42 kg/h 133 kg/h
Toluene 3,5 vol 1,75 vol
Water (washing) 4 vol 2 vol
Excess CMS & TEA 30% 10%
Color Orange(extra discoloration needed)
Pale yellow
Waste 6,2 kg/kg 3 kg/kg
Total capacity at La Mesta: 140 m³ with:
BATCH EQUIPMENT
Multi-purpose batch reactors:
High Pressure batch vessels: 2000 L stainless steel vessels up to 100 bars.
Exemple of reactions done under high pressure
NH3 gaz H2 Raney Nickel
50 bars - 50°C 40 bars - 50°C
MeSO4-
H2 / NiCH3NO2Me2SO4
MeONa
Recycling of ammonia - Semi batch hydrogenation
Separation / Drying equipment:
Once the reactions are performed, separation and isolation are very important operations. It is normally one of the final step which insures the quality of the product (removing of impurities, avoidance of cross contamination or contamination by foreign entities).For this, La Mesta can offer:
Mix of Stainless Steel, Inconel, Hastelloy and Glass Line vessels ranging from 100 L (pilot) up to 27 000 L.
Distillation columns in stainless steel or anti corrosion material up to 60 theoretical plates 1 mbar / 250°C.
Liquid separation:
Powder isolation with:
Sieving and milling capabilities
Products from our filter dryers and dryers are isolated directly in clean rooms to prevent any contamination of the product and to protect our operators. Products can be sieved or milled if required.
Filter dryers in Stainless steel (up to 2,2 MT batch size) or Hastelloy (up to 500 kg).Centrifuges horizontal or verticalDryers in stainless steel or anti-corrosion material.
REACTIONS PERFORMED IN BATCH AND/OR CONTINUOUS
Acetylene Chemistry - EGNO
Alkylation (methyl sulfate, …)
Amidation
Amination (NH3 gas, liq.)
Birch chemistry (Na in NH3 liq) - EGNO
Keto ester synthesis
Carbanion Chemistry
Carbonylation (CO)
Chlorination (SOCl2, SO2Cl2, Cl2)
Cyclization – Heterocyclic Chemistry
De-benzylation
De-carboxylation
De-halogenation
Epoxidation
High Temperature, Pressure reactions
Hydrogenation (RaNi, Pd, Rh, Ru, Pt)
Hydrohalogenation
Isomerization (sodium)
Nitromethane reactions
Oxidations (50% H2O2)
Phosphorous Chemistry (POCl3 – PCl3)
Radical addition
Reductions (NaBH4, LiAlH4, DiBAL)
Silane Chemistry
Horner-Wadsworth–Emmons reaction
Pinner Reaction
Sulfur chemistry (H2S) - EGNO
Williamson Reaction
Fluody can synthesize customized dyes according to customer’s request.
Custom Synthesis from Grams to Kilos Scale
R&D Study, Process Development and Critical Steps Optimization
Analytical characterization
Fine Chemicals:
Fluorescent dyes:
Fluody has developed the synthesis of many organic molecules, most of them under confidentiality agreements, for the following applications:
Fluody can offer cyanine fluorescent dyes, covering the whole visible spectrum till Near Infrared, tailored for molecular imaging (in vivo) and diagnostic applications (in vitro).
Fine chemicalsWorking standardsAPI impurities
YieldQualityEconomical ConsiderationsReproducibility and scalabilityEquipment Loading
PharmaceuticalLife SciencesCosmeticImagingElectronic
HPLCLC-MSUV/Vis Spectroscopy (absorption and fluorescent emission)
IRGCNMR
FLUODY S.r.l. is an Italian private owned company, part of Yriel Group.
www.fluody.com
FLUODY SERVICES
FLUODY is a Contract Research Organization specialized in high added value organic chemistry: R&D, process development and small scale production.Our chemists have more than 20 years’ expertise in designing and synthesizing organic molecules from grams to kilos scale.
FLUODY PRODUCTS
Examples below:
EGNO is a Fine Chemicals company located in Normandie France, close to Le Havre.
www.egno-chimie.com
Na / NH3
Na / NH3
R-Br
Acetylene Chemistry
Birch Reduction
H2S
H2S Chemistry
EGNO is specialized in highly pure liquid products ranging from fewkilos to few metric tons.
Pharma industryFlavor & FragrancesPheromones marketFine Chemistry
EGNO has developed since 1981 its own catalog products used in:
EGNO has also a CMO activity with the possibility to offer process development and manufacturing of products to fit customers special needs.
Process development on a targeted molecule starting from literature or from proper know-howExclusive synthesis based on a process provided by customers under secrecy agreementCatalogue Products
EGNO aims to serve its customers with flexibility and effectiveness, and can propose:
EGNO among its technologies has developed special know-how in non-trivial chemistry :
NO
Alkylation of enolate
Phenyl boronic acids
A WIDE RANGE OF CHEMISTRY
NO
Alkylation of enolate
Phenyl boronic acids
A WIDE RANGE OF CHEMISTRY
LA MESTA CHIMIE FINE S.A.S.1336 route de l’Esteron06830 GILETTEFRANCETel : +33 492 08 53 00Fax : +33 492 08 53 40 [email protected]
www.la-mesta.com
La Mesta Chimie Fine is a technology driven Custom Manufacturing company located in France. We offer multistep organic chemistry for sophisticated products since 1971.
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