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    Group 2

    j

    By Group 2

    Akash Singh

    Garvit Agarwal

    Eli Lilly Page 1

    Eli Lilly and

    CompanyEli Lilly and Company

    Answers That Matter

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    Gyan Prakash

    Jai Mohan Singh Sood

    Ramya Ramakrishnan

    Introduction

    Colonel Lilly, founder Eli Lilly

    Eli Lilly and Company has been in business more than 132 years. The global,

    research-based company was founded in May 1876 by Colonel Eli Lilly in

    Indianapolis, in the Midwestern section of the United States. A 38-year-old

    pharmaceutical chemist and a veteran of the U.S. Civil War, Colonel Lilly was

    frustrated by the poorly prepared, often ineffective medicines of his day.

    Consequently, he made these commitments to himself and to society:

    - He would found a company that manufactured pharmaceutical products of the

    highest possible quality.

    - His company would develop only medicines that would be dispensed at the

    suggestion of physicians rather than by eloquent sideshow hucksters.

    - Lilly pharmaceuticals would be based on the best science of the day.

    Eli Lilly Page 2

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    Major Drugs

    Prozac, the first major introduction in a new class of drugs for treatment of clinical depression.

    Zyprexa, now the world's top-selling antipsychotic for the treatment of schizophrenia

    Humulin insulin identical to that produced by the human body

    Ceclor, a member of the cephalosporin family, was eventually became the world's top-selling

    oral antibiotic

    Eli Lilly Page 3

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    Demand Function

    The demand for Eli Lilly is a function of the following factors

    A. Population Size of the country (Larger the population, higher the demand)

    B. Income levels in the country (Higher the income levels, higher the demand)

    C. Lifestyle of people ( as they may lead to change in disease patterns, and demand for newmedicines to combat lifestyle related diseases)

    D. Demand for health care services by the Patients (Larger demand for health care serviceswill lead to higher demand for medicines)

    E. Doctors Recommendations, which in turn are influenced by the Pharmaceutical

    Companies ( More the doctors recommend the companys medicines, more the demand)

    F. Geographical and climatic conditions prevalent in the region ( Influences the demand forparticular drugs)

    G. Awareness and acceptance of modern drugs by the society ( More the society accepts theusage of modern medicine, larger the demand for drugs)

    H. Infrastructure spending by the government, as it enables them to tap rural market (As themarket grows, demands also increases)

    Eli Lilly Page 4

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    I. Advertising and Sales Promotion ( People are at times influenced by advertisings whenthe buy drugs especially when they have not seen to a doctor)

    Demand function for Eli Lilly

    Revenue Function

    Eli Lilly Page 5

    Effect of Doctors Recommendation on demand

    for Eli Lilly

    D = f (A, B, C, D, E, F,

    G, H, I)

    Eli Lillys Demand Curve -

    Overall

    As most of its medicines are

    necessaries any change in

    price leads to relatively a

    very small change in price

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    Business Segments

    Eli Lilly's business is split into two major divisions: Pharmaceuticals and Animal Health. The

    Pharmaceutical division is responsible for the majority of revenue generation for the company.

    For FY 2010, Eli Lilly reported total sales of $23 billion and net income of $5 billion.

    Eli Lilly's best-selling product, Zyprexa is a treatment for schizophrenia, bipolar disorder, and

    other psychological disorders.

    Brief Description of the Various Segments from which Eli Lilly generates revenue -

    Neurology (45% of 2010 Sales)

    Eli Lilly's best-selling product, Zyprexa is a treatment for schizophrenia, bipolar disorder, and

    other psychological disorders. It has also been used off-label for depression and dementia.Zyprexa loses its patent protection in 2011. Cymbalta is a treatment for depression, anxiety, and

    pain management for diabetics. The product's patent expires in 2013.

    Endrocrinology (28% of 2010 Sales)

    Humalog is an insulin analog used for managing diabetes. Humalog's patent expires in 2013.Evista is an osteoporosis drug approved only for postmenopausal women. Evista's patent expiresin 2014. Humulin is another insulin analog used for managing diabetes, but has fewer sales thanHumalog.

    Oncology (16% of 2010 Sales)

    Gemzar is a chemotherapy drug for lung cancer, pancreatic cancer, and breast cancer. Like many

    other chemotherapy drugs, the drug also stops the division of healthy cells, leading to severe sideeffects. Gemzar began to face generic competition in 2009. Alimta is a lung and chest cancerdrug. Alimta's patent expires in 2016.

    Cardiovascular (10% of 2010 Sales)

    With a longer therapeutic window than Pfizer's Viagra, Cialis is the longest-lasting erectiledysfunction drug on the market. Cialis' patent expires in 2016.

    Animal Health (6% of 2010 Sales)

    Lilly's animal health division operates independently of its main pharmaceutical business.

    Research and Development ($4.9B in 2010)

    Eli Lilly's future revenues depend on gaining approvals for their drug molecules from theirproduct pipelines from the FDA. The majority of the company's pipeline is comprised of potentialcancer treating compounds, however there are also candidates for the treatment ofdiabetes,alzheimer's, depression, and schizophrenia in late-stage clinical trials.

    Eli Lilly Page 6

    http://www.wikinvest.com/wiki/Antipsychotic_drug_markethttp://www.wikinvest.com/wiki/Diabeteshttp://www.wikinvest.com/wiki/Osteoporosishttp://www.wikinvest.com/wiki/Diabeteshttp://www.wikinvest.com/wiki/Incidence_of_Cancerhttp://www.wikinvest.com/wiki/Incidence_of_Cancerhttp://www.wikinvest.com/wiki/Pfizer_(PFE)http://www.wikinvest.com/wiki/Erectile_dysfunctionhttp://www.wikinvest.com/wiki/Erectile_dysfunctionhttp://www.wikinvest.com/wiki/Diabetes_drug_markethttp://www.wikinvest.com/stock/Eli_Lilly_and_Company_(LLY)?action=edit&section=8http://www.wikinvest.com/stock/Eli_Lilly_and_Company_(LLY)?action=edit&section=7http://www.wikinvest.com/stock/Eli_Lilly_and_Company_(LLY)?action=edit&section=6http://www.wikinvest.com/stock/Eli_Lilly_and_Company_(LLY)?action=edit&section=5http://www.wikinvest.com/stock/Eli_Lilly_and_Company_(LLY)?action=edit&section=4http://www.wikinvest.com/stock/Eli_Lilly_and_Company_(LLY)?action=edit&section=3http://www.wikinvest.com/wiki/Diabeteshttp://www.wikinvest.com/wiki/Osteoporosishttp://www.wikinvest.com/wiki/Diabeteshttp://www.wikinvest.com/wiki/Incidence_of_Cancerhttp://www.wikinvest.com/wiki/Incidence_of_Cancerhttp://www.wikinvest.com/wiki/Pfizer_(PFE)http://www.wikinvest.com/wiki/Erectile_dysfunctionhttp://www.wikinvest.com/wiki/Erectile_dysfunctionhttp://www.wikinvest.com/wiki/Diabetes_drug_markethttp://www.wikinvest.com/wiki/Antipsychotic_drug_market
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    Revenue for Eli Lilly would be

    Revenue = Quantity of drugs sold * their respective Prices

    So,

    Revenue = f (Quantity sold, Price)

    As Eli Lillys goods are necessaries, the company faces an inelastic demand curve and it can

    increase its prices without much loss in quantity sold.

    Also even if prices fall, the quantity demanded will not increase considerably.

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    Eli Lilly Page 8

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    Cost Function

    The cost function of Eli Lilly can be defined as follows

    Cost = f (R&D, Sc, Lb, Pt, Mfg, Mktg)

    Where,

    R&D Research and Development

    Sc Scientists

    Lb Lab and related factors

    Pt Patents

    Mfg Manufacturing

    Mktg Marketing

    Exploring the Cost Variables

    1: Research and Development

    Research and development is one of the most important cost factor of a pharmaceutical

    company principally due to the fact that majority of their products are intensive in terms of the

    formulation and the scientific specification that goes into their product. No pharmaceutical company

    can launch a product without sufficient research and groundwork being put in the development of the

    product. However, the cost of R&D of a particular item in a product line might become negligible

    Eli Lilly Page 9

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    over a period of time, in the event of it being a successful product surviving for a period of time long

    enough to absorb the costs of research and development.

    2: Scientists

    The major labour costs associated with the pharmaceutical industry lies in acquiring talent,

    providing for their knowledge updation and retention of such talent. This cost of back-office labor is

    probably the next in priority with respect to cost factors. However, unlike R&D the cost f scientists is

    not a onetime/ non-recurring cost. Hence it would be classified under variable or semi-variable cost

    factors, assuming the cost function is being generated for a particular product.

    3: Lab and Related Factors

    Fixed cost factor of Eli Lilly include the laboratory and technology input outlay. The

    expenditure that the company incurs would be classified under Capital Expenditure. Consequently it

    is a long-term expenditure, meant to be absorbed over a period of time. Lab and technology expenses

    would be classified under fixed costs, whose per-unit costs can be expected to reduce with increase in

    production and diversification to newer product lines and variations. The possibility of change in

    technology, technology becoming obsolete, government regulations prohibiting the use of certain

    technology might alter the currents costs associated with production. It may be classified under semi-

    variable or contingent costs of the business.

    4: Patents

    Every product that the company has researched and developed has to be protected from beingpoached by competitive firms. Hence patenting is imperative for every product that the company

    develops. In certain countries, this cost can be bifurcated into product patent and process patent. It is

    majorly a one-time expenditure, and may be classified under fixed non-recurring expenditure.

    However the corresponding income generated from patents is relatively short-lived as compared to

    the benefits derived from the other costs, owing to the fact that patents are not non-terminating

    intellectual property rights. That is to say that after the expiry of the patent, the firm cannot draw the

    Eli Lilly Page 10

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    patent benefits anymore, even though it had incurred the initial cost of developing the product/

    process.

    5: Manufacturing

    The next process in the functioning of a pharmaceutical company is the mass manufacturing of the

    product. A classic case manufacturing front will include primary cost components like:

    i. Cost of production centre/ lease-rentals: The expenses incurred with respect to acquiring or

    leasing the manufacturing facility

    ii. Staffing: The expenses associated with procuring trained staff to handle the equipments in the

    facility, and training them in handling and maintaining hygiene.

    iii. Equipment: Cost of procuring manufacturing, processing and storage equipments.

    iv. Maintenance of equipment: The expenses incurred in maintaining, sterilizing and ensuring

    appropriate use of the equipments

    v. General precautionary measures/ initiatives: Safety and hygiene initiative to be undertaken in

    ensuring that the efficiency of product is maintained

    vi. Disposal of wastes/Emissions: Ensuring that the waste is properly disposed off without

    causing avoidable harm to the environment

    vii. Acquiring approvals and clearances from regulatory agencies: Certain regulatory agencies

    including the government charge for granting of approval to manufacture the product.

    viii.Special taxes, duties: The manufacture of certain drugs may attract duties associated with

    certain acts (Drug User Fee Act for instance), and this may also include carbon-print tax,

    considering the modern-day usage of technology-intensive manufacturing methods

    ix. Testing expenses (pre-manufacturing costs): The expenses that the company incurs with

    regards to testing the drug before proceeding to commercial manufacture.

    x. Cost of ingredients: Another major cost that the manufacturing front would incur would be

    the cost of ingredients. Being sensitive to time, climate and aspects like these, the company

    can also be expected to incur substantial costs on logistics, including transport, storage, and

    location. Hence implementation of best inventory practices may not be technically possible.

    6: Marketing

    Marketing, for pharmaceutical companies is primarily by targeting doctors and health-care

    institutes. Hence the marketing efforts are relatively restricted to a smaller target audience.

    Eli Lilly Page 11

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    Consequently, the intensity of the marketing efforts have to be high, in order to get a better success

    rate. This also means that samples given are directly proportional to the marketing efforts, assuming a

    situation of sales- representatives with significant level of integrity. Hence marketing efforts of Eli

    Lilly may be comprised into costs on representatives, samples, logistics and marketing tactics to cope

    with competitive products/firms.

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    Profit Function

    Profits = Total Revenue Total Cost

    Profit for a firm is dependent on the revenues generated by the firm.

    So Eli Lillys profit is based on its total revenue which is the total sales of its drugs.

    More specialized form of drugs enables Eli Lilly to charge higher prices which in turn

    enhances its profit function. Also those drugs which have a patent can make additional

    profits.

    Profit function for Eli Lilly can be calculated through -

    Profit = f (Revenue)

    Utility Function

    It is completely dependent on the customer satisfaction

    Mathematically Utility Function is derived as follows:

    Eli Lilly Page 13

    High

    Tech

    nolog

    y

    Used

    Low Profits GeneratedHigh

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    C1 the customer is absolutely satisfied; c2 customer is dissatisfied; x1 P(occurrence

    of c1); x2 P(occurrence of c2)

    Utility function = u(c1, c2, x1, x2) = x1*v(c1) + x2*v(c2); v(c1) the weights given forthe occurrence of the probability

    In the case of Eli Lilly the factors affecting the Utility Function are -

    Government action(s) against business

    Availability of medicines

    Length of time business has been operating.

    Complaint volume filed for business of this size.

    Response to complaint(s) filed against business.

    Resolution of complaint(s) filed against business.

    Eli Lilly Page 14