VIANZON, REYNALDO JR., M. BSN4 ELECTIVE 2 Physiologic Theories a. Biologic Clock Theory The aging-clock theory avers that aging results from a pre- programmed sequence, as in a clock, built into the operation of the nervous or endocrine system of the body. In rapidly dividing cells the shortening of the telomeres would provide just such a clock. This idea is in direct contradiction with the evolutionary based theory of aging. b. Immune Theory The autoimmune theory holds that aging results from an acceleration in autoantibodies that attack the body’s tissues. Diseases such as atrophic gastritis and Hashimoto’s thyroiditis (associated with aging) are probably autoimmune in this way. Neuroendocrine Theory a. Glycation Theory Suggests that glucose acts a mediator of aging. Glycation is the nonenzymic reaction between glucose & tissue protein. Studies conclude that glycation may have profound cumulative effect during a person's life. The negative effects of this process on proteins may be a major contributor to age changes. The effects of this process may be similar to elevated glucose levels & shorter life spans of diabetics
a. Biologic Clock TheoryThe aging-clock theory avers that aging
results from a pre-programmed sequence, as in a clock, built into
the operation of the nervous or endocrine system of the body. In
rapidly dividing cells the shortening of the telomeres would
provide just such a clock. This idea is in direct contradiction
with the evolutionary based theory of aging.b. Immune TheoryThe
autoimmune theory holds that aging results from an acceleration in
autoantibodies that attack the bodys tissues. Diseases such as
atrophic gastritis and Hashimotos thyroiditis (associated with
aging) are probably autoimmune in this way.Neuroendocrine
Theory
a. Glycation TheorySuggests that glucose acts a mediator of
aging. Glycation is the nonenzymic reaction between glucose &
tissue protein. Studies conclude that glycation may have profound
cumulative effect during a person's life. The negative effects of
this process on proteins may be a major contributor to age changes.
The effects of this process may be similar to elevated glucose
levels & shorter life spans of diabetics
