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Effects of Low-Frequency Bias Tones on Stimulus-Frequency Otoacoustic Emissions. Eric L. Carmichel Mentors Dr. Michael Dorman Dr. Lin Bian. Committee Members. Dr. Lin Bian (Committee Chair) Dr. Michael Dorman Dr. Andrea Pittman. Otoacoustic Emissions (OAEs). - PowerPoint PPT Presentation
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Effects of Low-Frequency Bias Tones on Stimulus-Frequency Otoacoustic
Emissions
Eric L. Carmichel
Mentors
Dr. Michael Dorman
Dr. Lin Bian
Committee Members
Dr. Lin Bian (Committee Chair)
Dr. Michael Dorman
Dr. Andrea Pittman
Otoacoustic Emissions (OAEs)
Faint acoustical signals originating from the inner ear but can be detected in ear canal
They can occur spontaneously (SOAEs) Can occur during and after stimulation of the
ear In general, healthy ears produce OAEs,
whereas hearing-impaired ears do not
Otoacoustic Emissions (OAEs)
OAEs are a by-product of the active mechanism of the inner ear (Probst et al., 1991)
When OHCs are damaged, the active mechanism is reduced in effectiveness or lost altogether
Compressive nonlinearity is associated with the active cochlear process
What does “compressive nonlinearity” mean?
Previous studies
Low-frequency biasing technique used to assess the dynamic nonlinearity of the inner ear
The bias tone can shift the cochlear partition. This produced an amplitude modulation of DPOAEs (Bian et al., 2002, 2007; Bian, 2004)
Cochlear partition—Consists of the basilar membrane, tectorial membrane, and the
Organ of Corti
Cochlear partition
Biasing the cochlear partition
Question: Can the biasing technique be applied to SFOAEs?
SFOAEs evoked in response to a single external tone
Measuring SFOAEs presents a unique challenge. As the name implies…
The emission is at the same frequency as the stimulus (or probe) tone
DPOAE visiblevia spectral
analysis
SFOAEcannot be
“seen”
Question: Can the biasing technique be applied to SFOAEs?
Cannot “see” the emission Separating a minute signal (i.e.,the emission)
requires an indirect method Can we study the effects of amplitude
modulating the SFOAE with a bias tone? More theory (oh boy!) and a hardware model
“OHC”
Probe
|Bias|
Bias tone
Question: Can the biasing technique be applied to SFOAEs?
We have a mathematical foundation We have a working hardware model Now all we need… are human ears!
Methods
Nine participants, ages 21 – 48 yrs (M=25) Ten ears total Eight normal ears with robust DPOAEs Two ears with profound hearing loss Bias tone and probe tone presented
simultaneously Ear canal acoustics recorded
Participants were
comfortably seated
Summary
Noninvasive nature of biasing technique—shows potential as a research tool and development of new clinical applications
Normal and impaired ears can be tested—potentially be applied in the differential diagnosis of cochlear pathologies
Just the beginning—present assay can be expanded upon
Acknowledgements
Thanks to committee members Dr. Bian, Dr. Dorman, and Dr. Pittman
Thanks to Tina Stinson for recruiting and screening participants
Thanks to the participantsMany thanks to all of you!