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EditorialHijacking of Endocrine and Metabolic Regulation inCancer and Diabetes
Eileen M. McGowan,1 Ann Simpson,1 James McManaman,2
Viroj Boonyaratanakornkit,3 and Anandwardhan A. Hardikar4
1Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW 2007, Australia2Division of Basic Reproductive Sciences, Graduate Program in Integrative Physiology, University of Colorado School of Medicine,Denver, CO 80045, USA3Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Rama I Road,Wangmai, Pathumwan, Bangkok 10330, Thailand4NHMRC Clinical Trials Centre, University of Sydney, NSW 2006, Australia
Correspondence should be addressed to Eileen M. McGowan; [email protected]
Received 31 December 2014; Accepted 31 December 2014
Copyright © 2015 Eileen M. McGowan et al. This is an open access article distributed under the Creative Commons AttributionLicense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properlycited.
This issue features articles related to endocrine andmetabolicregulation in cancer and diabetes. The modern diet, rich infat and refined carbohydrates, is creating worldwide obesityand diabetes epidemics. As early as 1959, Joslin and colleaguesspeculated about an association between diabetes and cancer,and current epidemiologic evidence indicates an increasedrisk of various types of cancer, with increased morbidity,in diabetes patients. The underlying mechanisms for thisassociation have not been fully elucidated as yet.
Cancer, diabetes, and obesity are all chronic diseaseswith common discernible alterations in metabolic processes.A sweet tooth and alterations in the glucose metabolismare common underlying themes. As scientists uncover moreevidence to support this idea, the current research focuses onpreventative strategies and treatments targeting disturbancesin common cellular metabolic pathways. Some of the drugsused clinically to treat diabetes have been shown to haveantitumour effects, as highlighted in the review of N. Turneret al. (University of New South Wales, Australia).
However, targeted treatments are not so easily imple-mented and have some inherent complexities, which derivefrom the possibility that some diabetes treatments may altercancer risk. Alternatively, some cancer treatments may beincompatible with diabetes therapies.Thiazolidinediones andmetformin are two common diabetes treatments which show
promise as cancer therapeutics. In this edition, E. Frohlichand R. Wahl (University of Tuebingen, Germany) discussthiazolidinediones as treatments for multiple cancer typeswhilst the review by D. Hatoum and E. M. McGowan(University of Technology Sydney, Australia) summarizesrecent advances in the use of metformin in comorbidity ofdiabetes and breast cancer. Although the in vitro evidence iscompelling, retrospective evidence for comorbidity therapyis controversial. As another option, contemporary researchdirected at targeting the sphingolipid rheostat holds greatpromise for diabetes and cancer therapy. The paper by K.Marzec et al. (Kolling Institute, Sydney, Australia) stronglysupports a role for targeting sphingosine kinase 1 (SphK1) incombinational treatments for the hard tomanage triple nega-tive breast cancers (TNBC), whereas the corresponding paperby N. K. Haass et al. (University of Queensland/University ofTechnology Sydney, Australia) focuses on the complexitiesinherent in the use of sphingosine kinase/sphingosine-1-phosphate modulators in the treatment of comorbidity ofcancer and diabetes.
It is becoming clear that obesity and cancer is not a ran-dom association. A. J. Hoy et al. (University of Sydney, Aus-tralia) emphasize that key pathways of fatty acid metabolismare altered in cancer. Associations between obesity, ovariansteroid hormones, and cancer are common themes in two
Hindawi Publishing CorporationBioMed Research InternationalVolume 2015, Article ID 386203, 2 pageshttp://dx.doi.org/10.1155/2015/386203
2 BioMed Research International
complementary papers by V. Boonyaratanakornkit and P.Pateetin (Chulalongkorn University, Thailand) and K. H.Joung et al. (Chungnam National School of Medicine, NorthKorea).These papers describe the strong prevalence of cancerin postmenopausal obese women. V. Boonyaratanakornkitand P. Pateetin raise the importance of developing a bet-ter understanding of the molecular mechanisms and sig-nalling pathways associated with alterations in endocrine andmetabolic regulation in obese women for improved breastcancer treatment.
IGF-1 and insulin are strongly associated with mostdiabetes related cancers. Several of the papers in this issuefocus on the importance of the insulin-like growth factors(IGFs) as novel targets for cancer therapies. K. Marzec et al.concentrate on IGF binding protein 3 (IGFP-3) as a criticaltarget for TNBCs. The original paper authored by the R.Pietras group (UCLA, USA) showed that elevated IGF-2 wasconcomitant with stimulated estrogen receptor-𝛽 (ER𝛽) andpoor overall survival. Furthermore, the paper by H. S. Atreyaet al. (Indian Institute of Science, India) advanced the conceptof blocking IGF and IGFBPs in cancer therapies.
The scope of this special issue highlights the growingawareness of the link between altered cellularmetabolism andthe risk of developing diabetes and cancer. Understandingand targeting altered cellular metabolism in individuals withor without diabetes, so as to reduce the risk of developingcancer, form the basis for future combinational treatments.
Acknowledgments
Thanks are due to all the authors for their contributions inthis special issue. We would especially like to acknowledgeDr. Lee Goodglick for his 25 years of dedication to cancerresearch. Dr. Goodglick recently passed away of pancreaticcancer during the preparation of this special issue.
Eileen M. McGowanAnn Simpson
James McManamanViroj Boonyaratanakornkit
Anandwardhan A. Hardikar
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