JointMeetingofthe

EASDIsletStudyGroup&BetaCellWorkshop

WestinBellevue,Dresden,May7-10th,2017

SUNDAY,MAY7th2017

From16:00h

REGISTRATIONANDDISTRIBUTIONOFMEETINGMATERIAL

18:30h

18:45h

OPENING

MicheleSolimena(fortheBCW)(Dresden,DE)

PierreMaechler(fortheEASD)(Geneva,CH)

KEYNOTELECTURE

Chair:PierreMaechler(Geneva,CH)

Phasetransition-drivenproteinassembly:anewviewonintra-cellular

compartimentalization

AnthonyHyman(Dresden,DE)

19:30h WELCOMERECEPTION

MONDAY,MAY8th2017

From8:00h

REGISTRATIONANDPOSTERMOUNTING

8:30h-10:30h

8:30h

9:00h

9:30h

10:00h

10:15h

10:30h

SESSION1:BETACELLDEVELOPMENT

Chair:LeifGroop(Malmö,SE)

Nkx2.2actsdownstreamofNeurog3tospecifypancreaticendocrine

lineages

LoriSussel(Denver,CO)

Beyondtranscriptionfactorsinthelineageselectionand

differentiationofpancreasprogenitors

AnthonyGavalas(Dresden,DE)

Myelintranscriptionfactorsrepressprecociousstressresponsesfor

thefunctionandsurvivalofpancreaticbetacells

GuoqiangGu(Nashville,TN)

Phosphoinositide3Kinase(PI3K)regulatesendocrinecellmotility

andpancreaticisletmorphogenesis(ShortTalk)

RobinKimmel(Innsbruck,AT)

Synaptotagmin13regulatesendocrinecelldelaminationduring

pancreasdevelopment(ShortTalk)

MostafaBakhti(Munich,DE)

COFFFEEBREAK

MONDAY,MAY8th2017

11:00h-13:00h

11:00h

11:30h

12:00h

12:30h

12:45h

13:00h

SESSION2:BETACELLMATURATIONANDREGENERATION

Chair:ChristopherWright(Nashville,TN)

Generatingfunctionallymaturebetacellsfromhumanstemcells

MatthiasHebrok(SanFrancisco,CA)

Glucotoxicblockofbetacellregeneration

YuvalDor(Jerusalem,IS)

mTORsignalingregulatesthemetabolicprogramingofbetacells

leadingtofunctionalmaturation

AnilBhushan(SanFrancisco,CA)

HeterogeneousNFkBactivitybalancesproliferationandfunctionin

agingbetacells(ShortTalk)

SharanJanjuha(Dresden,DE)

Transcriptomeanalysisofpancreaticcellsacrossdistantspecies

highlightsnovelimportantregulatorgenes(ShortTalk)

BernardPeers(Liège,BE)

LUNCH

MONDAY,MAY8th2017

14:00h-16:00h

14:00h

14:30h

15:00h

15:30h

16:00h

SESSION3:BETACELLFUNCTIONI

Chair:ShantaPersaud(London,UK)

NewandunexpectedrolesforSNAREproteinsinthepreservationof

functionalbetacellmass

DebbieThurmond(LosAngeles,CA)

Longitudinalinvivoimagingofisletsrevealsadominantroleofbeta

cellfunctionindiabetespathogenesis

StephanSpeier(Dresden,DE)

Regulationofbeta-cellfunctionandfatebyinsulin

JamesJohnson(Vancouver,CA)

Reversalofhumanbetacellfunctionaldamageinducedbylipo-

glucotoxicconditionsortype2diabetes

PieroMarchetti(Pisa,IT)

COFFEEBREAK

MONDAY,MAY8th2017

16:30h-18:30h

16:30h

17:00h

17:30h

18:00h

18:15h

18:30-20:30h

SESSION4:BETACELLFUNCTIONII

Chair:HindrikMulder(Malmö,SE)

Whyarelargeisletsunresponsivetoincretins?

SusumuSeino(Kobe,JP)

Fromabsencetohyperactivityofglutamatedehydrogenaseandthe

hypotohyperinsulinsim

PierreMaechler(Geneva,CH)

Geneticandnutritionalcontrolofbetacellconnnectivity

GuyRutter(London,UK)

Glucosedependentgranuledockinglimitsinsulinsecretionandis

decreasedinhumantype2diabetes(ShortTalk)

NikhilGandasi(Uppsala,SE)

Primaryciliadysfunctiondisruptsglucosetoleranceandbetacell

function(ShortTalk)

FrancescoVolta(Munich,DE)

POSTERPRESENTATIONSESSIONA(ODDNUMBERS)AND

REFRESHMENTS

TUESDAY,MAY9th2017

8:30h-13:00h

CITYTOURDRESDENWITHEXHIBITIONNEWMASTERSOROLD

MASTERS

13:00h

14:00h

14:45h-15:45h

14:45h

15:15h

15:45h

LUNCH

KEYNOTELECTURE

Chair:StefanBornstein(Dresden,DE)

Frommembraneraftstolipidomics:alife-longjourney

KaiSimons(Dresden,DE)

SESSION5:BETACELLMASSVS.DEDIFFERENTIATIONINT2D

Chair:GilLeibowitz(Jerusalem,IS)

Betacelllossintype2diabetesisnotaccountedforby

dedifferentiation

PeterButler(LosAngeles,CA)

Whenbetacellsfail:lessonsfromdedifferentiation

DomenicoAccili(NewYork,NY)

COFFFEEBREAK

TUESDAY,MAY9th2017

16:15h-18:15h

16:15h

16:45h

17:15h

17:45h

SESSION6:GENETICS&EPIGENETICSOFBETACELLSINT2D

Chair:MaureenGannon(NashvilleTN)

Usinghumangeneticsandgenomicstounravelcausalmechanisms

fordiabetes

AnnaGloyn(Oxford,UK)

Systemsbiologyonorgandonorandsurgicalpancreasspecimens

definesatranscriptomicsignatureoftype2diabeticislets

AnkeSchulte(Frankfurt,DE)

Non-codingRNAsandbetacellfunction

LenaEliasson(Malmö,SE)

Monogenicdiabetesasmodelsofbetacellorganelledysfunctionin

type2diabetes

MiriamCnop(Brussels,BE)

18:15h-20:15h

POSTERPRESENTATIONSESSIONB(EVENNUMBERS)AND

REFRESHMENTS

WEDNESDAY,MAY10th2017

9:00h-10:30h

9:00h

9:30h

10:00h

10:15h

SESSION7:THESOCIALENVIRONMENTOFTHEBETACELLS

Chair:EduardMontanya(Barcelona,SP)

Sharingiscaring:howbetacellfunctiondependsontheislet

environment

AlejandroCaicedo(Miami,FL)

Molecularandfunctionalinterplaybetweenalpha-andbeta-

cellularclocksinmouseandhumanmodels

CharnaDibner(Geneva,CH)

Elucidatingtheroleofpancreaticpericytesindiabetes-associated

betacelldysfunction(ShortTalk)

LimorLandsman(TelAviv,IS)

PYYmodulatespancreaticisletsecretoryfunctionandactsasaDPP-

IVsubstratetoregulateinsulinsecretion(ShortTalk)

ClaudiaGuida(Oxford,UK)

10:30h

COFFEEBREAK

WEDNESDAY,MAY10th2017

11:00h-13:00h

11:00h

11:30h

12:00h

12:30h

SESSION8:BETACELLTHERAPY

Chair:OleMadsen(Copenhagen,DK)

Reconstructinghumanpancreaticorganogenesis

RaphaelScharfmann(Paris,FR)

Drugdesignforbetacellprotectionindiabetesmellitus:NMDA

receptorantagonists

EckhardLammert(Düsseldorf,DE)

Advancesinpharmacologictherapyforhumanbetacell

regeneration

AndrewStewart(NewYork,NY)

Currentstatusandfutureperspectivesindiabetestherapy-from

cells,pills,andchimera

BarbaraLudwig(Dresden,DE)

13:00h

LUNCH

WEDNESDAY,MAY10th2017

14:00h-16:00h

14:00h

14:30h

15:00h

15:30h

15:45h

SESSION9:BETACELLIMMUNEINTERACTION

Chair:EzioBonifacio(Dresden,DE)

Theresidentphagocytesofpancreaticisletshaveaseminalrolein

isletdevelopmentandinflammation

EmilUnanue(St.Louis,MO)

Complexitiesofbetacellfailureintype1diabetes

ClaytonMathews(Gainsville,FL)

Coordinatedanalysisusingcomplementarymethodologiesrevealsa

viralsignatureanddemonstratesalowlevelenteroviralinfectionin

thepancreasintype1diabetes

TeresaRodriguez-Calvo(Munich,DE)

Anovel,highlyproliferativepopulationofisletendocrinecellsin

adolescentandadulthumanpancreata(ShortTalk)

JakeKushner(Houston,TX)

Exosome-mediatedtransferofmicroRNAsfromlymphocytestobeta

cellscontributestotype1diabetesdevelopment(ShortTalk)

ClaudianeGuay(Lausanne,CH)

16:00h

COFFEEBREAK

WEDNESDAY,MAY10th2017

16:30h-17:30h

16:30h

17:00h

17:30h-18:30h

17:30h

19:30h-24:00h

SESSION10:THEROLEOFALPHACELLSINISLETFUNCTION

Chair:AndersTengholm(Uppsala,SE)

Betacellreconstitutionbymodulationofisletcell-type

interconversion

PedroHerrera(Geneva,CH)

Somatostatinmediatesglucagonostaticeffectofinsulin

PatrikRorsman(Oxford,UK)

KEYNOTELECTUREANDCLOSINGREMARKS

Chair:MicheleSolimena(Dresden,DE)

Controlofpancreatichormonesecretionbybrainglucosesensing

networks

BernardThorens(Lausanne,CH)

FAREWELLDINNERAT“SCHLOSSALBRECHTSBERG”

Thursday,MAY11th2017

9:00h-17:00h

DEPARTUREOROPTIONALTOURSTO…

…DresdenMuseums

…CityofMeissen

…PillnitzCastle

…SaxonianSwitzerland