Upload
others
View
7
Download
0
Embed Size (px)
Citation preview
1
Delhi Technological University
(Formerly Delhi College of Engineering Delhi)
Department of Applied Physics
Program M Tech (Nano-Science amp Technology)
Nanotechnology is a rapidly advancing area of scientific and technological opportunity that applies
the tools and processes of nano microfabrication to build devices and study their properties in
nanoscale regime It is a scientific urge to create new micro-nano materials based devices to better
understand their properties in nanoscale regime
To train engineers and scientists with diverse background Applied Physics department has taken
initiative to start the two year ldquoMTech (Nano-science amp technology)rdquo program from the academic
year 2009-2010 The curriculum has been designed in a manner so that students are trained to
various aspects of nanomaterials latest development in the synthesis characterization and
fabrication of nanomaterials based optical and electronic devices Besides the commitment to
trained students in nanotechnology we would like to develop a bridge between research and
industry by taking the discoveries from laboratories and realizing their real-world application
benefit to society
2
COURSE CURRICULUM amp SCHEME OF EXAMINATION
for
MTech (Nano-Science amp Technology) 2017-2018
Semester I Examination November 2017
Semester II Examination May 2018
Semester III Examination November 2018
Semester IV Examination May 2019
Scheme of Examination for MTech Nano-Science and Technology (Offered by Applied Physics Department)
Sem Group Details No of papers
Marks Internal (Each Paper)
Marks External
(Each Paper)
Total Marks (Each Paper)
Semester Total
I A Course work of 3 Core Theory papers 3 50 100 150 1000
(20 Credits)
1 Laboratory 1 30 70 100 B Course work of 2 Core Theory papers 2 50 100 150
1 Laboratory 1 30 70 100 Self study Open area Seminar-I - 50 - 50
II C Course work of 1 Core amp 2 Elective Theory Papers
3 50 100 150 1000
(20 Credits)
1 Laboratory 1 30 70 100 D Course work of 2 Elective Theory papers 2 50 100 150
1 Laboratory 1 30 70 100 Minor project-I - 50 - 50
III E Course work of 2 Elective Theory papers 2 50 100 150 1000
(20 Credits) Self study Open area Seminar-II - 50 50 100
Minor Project-II - 150 150 300 Major Project Part-I - 150 150 300
IV F Major Project Part-II - 500 500 1000 1000
(20 Credits) TOTAL 4000
(80 Credits)
3
COURSE STRUCTURE FOR MTech FIRST SEMESTER (Nano-science amp Technology)
SNo Course No Subject LTP Evaluation Internal External
Total Marks
Credit
1 AP-501 Computational Physics and Programming
300 50 100 150 3
2 AP-502 Chemistry for Nano -science and Technology
300 50 100 150 3
3 AP-503 Physics for Nano-science and Technology
300 50 100 150 3
4 AP-504 Engineering of Materials Laboratory-I 002 30 70 100 2
5 AP-551 Characterization of Materials 300 50 100 150 3
6 AP-552 Fundamental of Nano-science and technology
300 50 100 150 3
7 AP-553 Engineering Materials Laboratory-II 002 30 70 100 2
8 AP-554 Self study Open Area Seminar I 001 50 - 50 1
TOTAL 20 hrs 1000 20
COURSE STRUCTURE FOR MTech SECOND SEMESTER (Nano-science amp Technology)
SNo Course No Subject LTP Evaluation Internal External
Total Marks
Credit
1 AP-601 Physics of Low Dimensional Systems 300 50 100 150 3
2 AP-6021 Materials Science at Nanoscale (Elective-I)
300 50 100 150 3
3 AP-6031 Processing amp Fabrication of Nanostructures (Elective-II)
300 50 100 150 3
4 AP-6511 Nano electronics amp Nano photonics (Elective-III)
300 50 100 150 3
5 AP-6521 Semiconductors Nanostructures amp Devices (Elective-IV)
300 50 100 150 3
6 AP-604 Processing amp Fabrication of Nanostructure Lab
002 30 70 100 2
6 AP-653 Characterization of Materials Science lab
002 30 70 100 2
7 AP-654 Minor Project I 001 50 - 50 1
TOTAL 20 hrs 1000 20
4
COURSE STRUCTURE FOR MTech THIRD SEMESTER (Nano-Science amp Technology)
SNo Course No Subject LTP Evaluation
Internal External
Total
Marks
Credit
1 AP-7011 Nano Electromechanical Materials amp
Devices (Elective-V)
300 50 100
150 3
2 AP-7012 Functional material and device
(Elective-V)
3 AP-7021 Nano Biotechnology (Elective-VI) 300 50 100 150 3
4 AP-703 Self study Open Area Seminar II 002 - 100 100 2
5 AP-704 Minor Project II 006 150 150 300 6
6 AP-705 Major Project I 006 150 150 300 6
TOTAL 20 hrs 1000 20
COURSE STRUCTURE FOR MTech FOURTH SEMESTER (Nano-Science amp Technology)
SNo Course No Subject LTP Evaluation
Internal External
Total
Marks
Credit
1 AP-801 Major Project II - 500 500 1000 20
TOTAL 1000 20
5
SYLLABUS MTech (NanoScience amp Technology)
AP-501 Computational Physics and Programming (3-0-0)
Unit I
A review of the numerical techniques (Interpolations differentiations integrations nonlinear
equations the bisection methods Newtonrsquos method root findings Differential equations Eulerrsquos
method the Runge-Kutta method Matrices-inverting finding eigen values and eigen functions
Bessel functions Hermite Legendre and Lagurre polynomials etc
Unit II
Simple problems based on section-I using Matlab Mathematica (mechanics optics and quantum
mechanics ) Atomistix and related softwares Introduction to Lab view software
Unit III
C++ Programming Introduction to Object oriented Paradigm Basic concept of Object Oriented
Programming (OOP) Benefits of OOP Applications of OOP Classes and Objects- specifying a
class memory allocations for objects static daa members and member functions array of objects
Objects as function arguments friendly Functions returning objects constructors and destructors
Unit IV
Inheritance and Polymorphisms Inheritance types of inheritance Derivation-Public private and
protected polymorphism types of polymorphism- compile time and runtime function overloading
operator overloading virtual functions
References
1 Handbook of Theoretical and Computational Nanotechnology Eds Michael Rieth and Wolfram
Schommers 2006
2 Introductory Computational Physics Kelvin and Godunov (Cambridge)
3 Computational physics RC Verma KC Sharmaamp PK Ahluwalia
4 Introduction to Computer simulations Gould Tobochnik etal (Addition Wesely 2006)
5 Visual basic and C++ Schuam Series
6 Mat labs Programming by Rudrapratap Singh
7 Mathematical Physics Harper
8 Applied mathematics for engineers amp Physicist Pipes and Harvil
9 Numerical Recepies in C The art of scientific Computing WH Press
10 Computer Programming Language Addition Wesely
11 Object oriented Programming in turbo C++ Robert Lafore
6
AP-502 Chemistry for Nano Science amp Technology (3-0-0)
Unit I
Surface adsorption Definition Significance and Applications of it Freudlich and Langmiur
Adsorption Isotherm Gibbrsquos Isotherm Their fundamental approach to Nanomaterials
Unit II
Colloidal chemistry Colloidal properties origin of charge on colloidal properties Determination of
colloidal particle size Synthesis of Nano materialsNano systems employing chemical
precipitation coprecipitation sol-gel synthesis microemulsion thermolysis Electrochemical and
photochemical methods
Unit III
Nano polymersNanocomposites Synthesis Characterization Properties and applications of Nano
polymersNanocomposites ie Polymers metal oxide glass and ceramic based nano composites and
their use in catalysis
Unit IV
Metal and Alloy Nanoparticles Preparation and Stabalization of MetalAlloy nanoparticles particle
size determination particle size distribution their conducting semiconducting and catalytic
properties Separation and purification of Nano particles by Membrane Technology Ion Exchange
Membranes Electrodialysis Reverse Osmosis Ultrafiltration Microfiltration and Nanofiltration
Techniques
References
1 Nanocomposites Science and Technology by PM Ajayan LS Schodler Wiley New York
2 Chemistry of Nanomaterials Synthesis properties and applications by C N R Rao Wiley New York
3 Nanochemistry A chemical approach to nanomaterials- Royal Society of Chemistry Cambridge UK
2005
4 Active Metals preparation Characterization and Application by A Frustner Ed VCH New York 1996
5 Membrane Handbook WSWinston Ho amp Kamlesh K Sirkar Chapman hall (1992)
6 Colloidal Dispersion ndash Russel WB Saville DA Cambridge University Press 1989
7 Surfactants and Polymers In Aqueous by K Holmberg B jonsson B Kromberg Wiley England 2004
7
AP-503 Physics for Nano Science and Technology (3-0-0)
Unit I
Review of fundamentals of Quantum mechanics Schroumldinger equation tunneling density of states
free electron theory of metals The angular momentum problem The spin half problem and
properties of Pauli spin matrices
Unit II
Approximate methods Time independent and time dependent perturbation Theory for non-
degenerate and degenerate energy levels the variational Method WKB approximation adiabatic
approximation sudden approximation
Unit III
Statistical Mechanics Microstates and entropy and its statistical definition Entropy of mixing
Gibbrsquos free energy Gibbrsquos paradox phase space density ergodic hypothesis Liouvillersquos theorem
The microcanonical- canonical- and grand canonical ensemble and their connections Fluctuations
Classical Statistical systems Boltzman statistics and quantum statistical systems Fermi-Dirac and
Bose-Einstein Statistics and their applications (an overview)
Unit IV
Crystal structure crystallographic planes Miller indices Braggrsquos law X-ray Diffraction particle
size determination Confinement and transport in Nanostructures Current reservoirs and electron
channels conductance formula for nanostructures quantized conductance Local density of states
Ballistic transport Coulomb blockade Diffusive transport Fock space Dielectric properties
Polarization ferroelectric behaviour Optical Properties Photoconductivity Optical absorption and
transmission Photoluminescence Fluorescence Phosphorescence Electroluminescence
References
1 Quantum Physics- A Ghatak
2 Quantum Physics of atoms Molecules Solids Nuclei and particles 2nd edition by Eisberg Robert
Resnik Robert
3 Principles of Quantum Mechanics 2nd ed ndash R Shankar
4 Statistical Physics by K Huang
5 Statistical Mechanics- Landau amp Lifshitz
6 Statistical Mechanics- Sonntag
7 Introduction to Solid State Physics- C Kittel Solid State Physics- AJ Dekker
8 The Physics and Chemistry of Solids- Stephen Elliott amp SR Elliot
9 Scanning Probe Microscopy Analytical Methods(NanoScience and Technology)-Roland Wiesendanger
10 Advance X-ray Techniques in Research and Industries ndash AKSingh(editor)
11 Basic Solid State Chemistry ndash Anthony RWest
8
AP-551 Characterization of Material (3-0-0)
UNIT I
X-ray Diffraction Braggrsquos law Application in crystallography Diffractogram Paricle size
determination using XRD
UNIT II
Probe techniques Atomic force Microscopy (AFM) scanning electron microscopy (SEM)
Scanning tunneling microscopy (STM) Transmission Electron Microscopy (TEM) High
Resolution Transmission Electron Microscopy (HRTEM)
UNIT III
Infrared Spectroscopy Raman Spectroscopy Electronic spectroscopy for atoms and molecules
Spin Resonance Spectroscopy Nuclear Magnetic Resonance spectroscopy (NMR)
UNIT IV
Deep level transient spectroscopy (DLTS) Kelvin-probe measurements Nanoscale current-voltage
(I-V) investigations Capacitance-Voltage (C-V) Relationships
References
1 Nanostructures amp Nano Materials Ghuzang Cao
2 Handbook of Nanophase amp Nanomaterials (vol IampII) Zhong Lin Wang
3 Fabrication of fine pitch by holography electron beam lithography and nano-imprint lithography
(proceeding papers) Author(s) Darren Goodchild Simon Wingar Nak Kim
4 Microfabrication and Nanomanufacturing- Mark James Jackson
5 Processing amp properties of structural nanomaterials- LeonLShaw(editor)
6 Fundamentals of molecular spectroscopy C N Banwell Tata McGraw
9
AP-552 Fundamentals of Nano-Science amp Technology (3-0-0)
UNIT I
Introduction and Classification What is nanotechnology The Canvas of Nano Classification of
nanostructures Nanoscale architectures Effects of nanometer length scale Changes to the system
total energy changes to the system structure Nanoscale dimensions and its affects properties
UNIT II
Investigating and manipulating materials at nanoscale Introduction Electron microscopies
Scanning probe microscopies Other kinds of microscopies X-Ray Diffraction Associated
techniques
UNIT III
Fabrication Methods Top Down Processes Bottom Up Processes of Silicon nanowire ZnO
nanowire Carbon nanotubegrapheme Ordering of nanosystems Preparation Safety and Storage
issues Fa
UNIT IV
Society and Nano Societal implications of nanotechnology Introduction From first Industrial
Revolution to the Nano Revolution Issues and outlook Harnessing Nanotechnology for social and
economic development
References
1 Introduction to Nanotechnology Charles PPoole Jr and Frank J Owens
2 Nanotechnology Principles and Practices Sulabha K kulkarni
3 Nanoscale Science and Technology Robert W Kelshall Ian W Hamley and mark Geoghegan
4 NanoThe Essentials ndashUnderstanding Nanoscience and Nanotechnology ndashT Pradeep
5 Handbook of Nanotechnology Bharat Bhusan
10
AP-601 Physics of Low Dimensional Systems (3-0-0)
UNIT I
Maxwell-Boltzmannrsquos statistics Fermi-Dirac statistics and fermions Paulirsquos exclusion principle
Bose Einstein statistics Bosons Bose condensation
UNIT I
Molecular structure Born oppenheimer approximation electronic structure ionic and covalent
bonding H2 H2+ vibrational and rotational structure
UNIT III
Molecular spetra microwave infrared and optical spectra of molecules selection rules suitable
examples
UNIT IV
Transport properties parallel and perpendicular transport quantization of conductance density of
states coulomb blockade kondo effect Hall quantum Hall and fractional Hall effects Other
relevant topics
References
1 Quantum Mechanics by L I Schiff
2 Quantum Mechanics by J L Powell and Crasmann
3 Introduction to Quantum Mechanics by Pauling amp Wilson
4 Quantum Mechanics by A K Ghatak amp S Loknathan
5 The Physics of low-dimensional semiconductors An introduction by J H Davies
6 Concepts of Modern Physics by Arthur Beiser
7 Physics of Molecules by Wolf Gang Demtroder
8 Handbook of Molecular Physics amp Quantum Chemistry by Stephen Wilson
9 Quantum Heterostructures by Maiteir and others
11
AP-6021 Materials Science at Nanoscale (3-0-0)
UNIT I
Single crystalline polycrystalline and amorphous structures crystal structure classification of
crystals imperfection in solids grain boundaries and its effect on mechanical properties Phase
transitions in nanosystems-comparison to large systems
UNIT II
Carbon molecules nature of carbon bonds new carbon structures small carbon clusters C60-
crystal structure larger and smaller fullerenes Buckyballs Carbon Nanotubes-fabrication
structure electrical vibrational and mechanical properties
UNIT III
Applications in field emission shielding computers fuel cells sensors catalysis mechanical
reinforcement
Bulk nanostructured materials synthesis mechanical and electrical properties metal nanocluster
composite glasses porous silicon natural nanocrystals nanoparticles in zeolites crystals of metal
naoparticles nanoparticle lattices in suspensions photonic crystals nanocopmposites
nanoceramics ceramic matrix composites
UNIT IV
Nanostructured ferromagnetism effect of nanostructuring nanomagnets nano carbon ferromagnets
giant and colossal magnetoresistance ferrofluids Nanocmposites of dielectric piezoelectric and
ferroelectric materials Polarization types frequency dependence other relevant current topics
References
1 Materials Science amp Engineering An introduction by W D Callister
2 Introduction to Solid State Physics by C Kittel
3 Solid State Physics by A J Dekker
4 Solid State Physics by Aschroft amp Mermin
5 Nanocomposite Science and Technology by Ajayan Schadler and Braun
6 Principles of Nanotechnology by G Ali Mansoori
7 Nanomaterials Nano-tech amp Design by Michael F Ashby
12
AP-6031 Processing amp Fabrication of Nanostructures (3-0-0)
UNIT I
Fundamental concepts of Bottom-up and top down approaches self assembly and self organization
formation of nanostructure by mechanical milling (ball milling)
UNIT II
Synthesis of carbon nanotubes growth mechanism arc discharge laser ablation sputtering and
growth from solutions and melts
UNIT III
Chemical vapor deposition plasma enhanced CVD thermal CVD vapor phase growth laser
assisted thermal CVD CoMoCat process High pressure CO dispropornation process flame
synthesis pulsed laser deposition (PLD)
UNIT IV
Fabrication of nanoparticles synthesis of colloidal particles synthesis of nanogold particles
synthesis of nanocomposites and nanostructures fabrication of quantum dots nanowires nanorods
nanointermetallics controlled colloidal synthesis Synthesis of polymer supported clusters and
polymeric nanofibers
Nanolithography electron beam and focused ion beam lithographies other relevant current topics
References
1 Nanotechnology by Gregory Timp
2 Introduction to Nanoscale Science amp Technology by M Di Ventra et al
3 Nanophotonics by Paras N Prasad
4 Microlithography Sciences amp Technology ndash Sheats J R and Amith B W (Marcel Dekker Inc New York)
5 Nanolithography A borderland between STM EB IB and X-ray lithographies- M Gentili et al
(Springer)
13
AP-6511 Nano Electronics amp Nano photonic (3-0-0)
UNIT I
Photons and electrons- similarities and differences confinement of photons and electrons
Nanoscale optical interactions-axial and lateral nanoscopic localization quantum confinement
effects cooperative transitions and emission
UNIT II
Quantum well double quantum wells wires dots rings size effects manifestation of quantum
confinement-optical properties conduction electrons and dimensionality potential wells resonant
tunneling and ballistic transport single-electron tunneling infrared detectors quantum dot lasers
UNIT III
Photonic crystals-basic concepts features of photonic crystals photonic crystal optical circuitry
non-linear photonic crystals photonic crystal fibers optical communication and sensors
UNIT IV
Basics of nanoelectronics and molecular electronics break junction nanowires nanocircuits single
molecule magnet molecular conductance molecular logic gate MEMS other relevant topics
Fundamentals of Spintronics spin polarized transport Kondo effect Kubo effect spin relaxation
and injection Spintronics memory devices and applications
References
1 Nanophotonics by Paras N Prasad
2 Introduction to Nanoscale Science amp Technology by M Di Ventra et al
3 Handbook of Photonics by Mool Chand Gupta amp John Ballato
4 Optical properties of photonic crystals by K Sakoda
5 Detection of optical and infrared radiation by Kingston amp Mac Adam
6 Introduction to Nanotechnology by C P Poole Jr and Franks J Owens
7 Spintronics fundamentals and applications by I Zutic and SD Sarma
8 Introduction to spintronics by Supriyo Bandopadhayay
9 Spin electronics by David D Awschalom
10 Quantum Electronics by A Yariv
14
AP-6521 Semiconductors Nanostructures amp Devices (3-0-0)
UNIT I
Basics of semiconductors microelectronic devices and technology silicon technology processing
of III-V semiconductors semiconductor nanoparticles synthesis cluster compounds quantum dots
using MBE CVD and MOCVD
UNIT II
Semiconducting nanoparticles size dependent physical properties band-gap variations-quantum
confinement Fundamentals of carrier transport in quantum structures electrical transport properties
in semiconductors nanostructures temperature effects resonating tunneling diodes structure and
operation of MOS
UNIT III
Small dimension effects Nanoscale MOSFET transistors LED and solar cells Doping nano
particles
Semiconductor nanowires fabrication and integration quantum conductance effects in
semiconductors porous silicon nanobelts nanoribbons nanosprings
UNIT IV
Single electron tunneling superconducting single electron transistor implementation of single
electron transistors applications of single electron transistors other relevant current topics
References
1 Introduction to Nanoscale Science amp Technology by M Di Ventra et al
2 Nanotechnology by Gregory Timp
3 Nanophotonics by Paras N Prasad
4 Introduction to Nanotechnology by C P Poole Jr and Franks J Owens
5 Encyclopedia of Nanotechnology by Hari Singh Nalwa
6 Handbook of Semiconductor Nanostructures amp Nanodevices Volumes-1-5 A A Balandin and K L Wang
7 Nanostructures and Nanomaterials ndash Synthesis Properties amp Applications by Cao amp Guozhong
15
AP-7011 Nano Electromechanical Materials amp Devices (Elective-V (3-0-0)
UNIT I
Introduction of carbon materials Diamond nanodiamond fullerene graphene carbon fiber and
amorphous carbon Synthesis route CVD for synthesis of nanodinamond carbon nanotube and
graphene and other methods of preparation of CNT and graphene
UNIT II
Structure and properties of carbon nanotubes and graphene Electrical Optical Mechanical
Vibrational properties etc
UNIT III
Applications of carbon nanotubes and graphene Biosensors FET Field emission Fuel Cells
Display devices
UNIT IV
Functionalization and purification method for carbon nanotubes Oxidative Purification Defect
Functionalization ndashTransformation and Modification of Carboxylic Functionalization like
Amidation Thiolation Halogenations Hydrogenation Addition of Radicals Addition of
Nucleophilic Carbenes Sidewall Functionlaization through Electrophili Addition Cycloadditions
Carbenes Addition Addition of Nitrenes Noncovalent Exohedral Functionalization Endohedral
Functionalization
References
1 Nanoscale materials -Liz Marzan and Kamat
2 Physical properties of Carbon Nanotube-R Satio
3 Applied Physics Of Carbon Nanotubes Fundamentals Of Theory Optics And Transport Devices - S
Subramony amp SV Rotkins
4 Carbon Nanotubes Properties and Applications- Michael J OConnell
5 CARBON NANOTECHNOLOGY- Liming Dai
6 Nanotubes and Nanowires- CNR Rao and A Govindaraj RCS Publishing
16
AP-7021 Nanobiotechnology (3-0-0)
UNIT I
Biological Methods of Synthesis Use of bacteria fungi Actinomycetes for nanoparticle synthesis
Magnetotactic bacteria for natural spynthesis of magnetic nanoparticles Mechanism of formation
Viruses as components for the formation of nanostructured materials Synthesis process and
application Role of plants in nanoparticle synthesis
UNIT II
Microorganisms for synthesis of nanomaterials and for toxicity detection Natural and artificial
synthesis of nanoparticles in microorganisms Use of microorganisms for nanostructure formation
Testing of environmental toxic effect of nanoparticles using microorganisms
UNIT III
Nanocomposite biomaterials teeth and bone substitution Natural nanocomposite systems as spider
silk bones shells organic-inorganic nanocomposite formation through self-assembly Biomimetic
synthesis of nanocomposite material Use of synthetic nanocomposites for bone teeth replacement
UNIT IV
Nanobio Systems Nanoparticle-biomaterial hybrid systems for bioelectronic devices Bioelectronic
systems based on nanoparticle-enzyme hybrids nanoparticle based bioelectronic biorecognition
events Biomaterial nanocircuitry Protein based nanocircuitry Neurons for network formation
DNA nanostructures for mechanics and computing and DNA based computation DNA based
nanomechanical devices Biosensor and Biochips
References
1 Bionanotechnology Lessons from Nature by David S Goodsell
2 Nanomedicine Vol IIA Biocompatibility by Robert A Freitas
3 Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology - Hari Singh
Nalwa
4 Nanobiotechnology ed CMNiemeyer CA Mirkin
5 Nanocomposite Science amp Technology Ajayan Schadler amp Braun
6 BioMEMS (Microsystems) - Gerald A Urban
7 Introduction to Nanoscale Science and Technology (Nanostructure Science and Technology) ndash
Massimiliano Di Ventra
8 Nanosystems Molecular Machinery Manufacturing and Computation - K Eric Drexler
9 Springer Handbook of Nanotechnology - Bharat Bhushan
10 Nanobiotechnology ed CMNiemeyer CA Mirkin
12 Nanomedicine Vol I Basic Capabilities
13 Nanomedicine Vol IIA Biocompatibility - Robert A Freitas
17
Self-Study Open Area Seminar-I ampII
Compulsory seminar by each candidate on the emerging topics related to nanotechnology
Minor (I ampII) or Major Project
A minor project related to emerging areas in the nanotechnology is to be completed Emphasis will
be given of area related to synthesis characterization and device fabrication Faculty member will
help for selecting area of major projects
Scheme of Examination and Syllabus
MTech in Industrial Biotechnology
Department of Biotechnology Delhi Technological University
Bawana Road New Delhi -110042
MTech in Industrial Biotechnology Biotechnology Industry Organization (BIO) USA has mentioned three major waves in the field of
biotechnology The first wave Green Biotechnology refers to agricultural biotechnology The
second wave Red Biotechnology refers to pharmaceutical and medical biotechnology while the third
wave White Biotechnology refers to industrial biotechnology Industrial biotechnology is mainly
based on biocatalysis (the use of enzymes and cells to catalyse chemical reactions) and fermentation
technology (directed use of micro-organisms) in combination with recent breakthroughs in the
forefront of molecular genetics and metabolic engineering It includes manufacturing of antibiotics
(cephalosporins streptomycin penicillin) food (yoghurt cheese single cell protein mushroom
probiotics) renewable energy (bioethanol biodiesel biohydrogen) health care (growth hormone
antibodies) biopolymers (polyhydroxy butyrate polylactic acid) enzymes (protease lipase amylase
cellulase pectinase xylanase) in various industries (pulp and paper detergent textile food
processing industry) Industrial biotechnology also involved in bioremediation microbial
degradation of pollutants (hydrocarbons polychlorinated biphenyl polyaromatic hydrocarbons)
Biological waste water treatment is undoubtedly one of the most important biotechnological
processes which have been used to treat municipal waste and industrial waste water The proposed
syllabus has been developed to address the need of well trained industrial biotechnologist cutting
edge RampD for this field The trained manpower will be well versed in techniques of protein science
bio-catalysis engineering biosynthesis microbial manufacturing engineering biological systems and
bio-process engineering Moreover they can easily implement these hands on training in industry to
increase the yield more accurately
Delhi Technological University Delhi
Department of Biotechnology
Scheme of Examination
MTech in Industrial Biotechnology
First semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-521 Bioenergy 3 1 0 50 100 150 3
BT-522 Food Engineering
amp Biotechnology
3 1 0 50 100 150 3
BT-523 Enzyme
Engineering amp
technology
3 1 0 50 100 150 3
BT-571 Industrial Plant
Biotechnology
3 1 0 50 100 150 3
BT-572 Bioinstrumentation 3 1 0 50 100 150 3
BT-573 Food engineering
and Biotechnology
Lab
0 0 2 30 70 100 2
BT-524 Bioinstrumentation
Lab
0 0 2 30 70 100 2
BT-574 Self Study open
area seminar-I
0 0 1 50 - 50 1
TOTAL 360 640 1000 20
Second semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-621 Biopharmaceuticals 3 1 0 50 100 150 3
BT-6221 Bioprocess
Engineering
3 1 0 50 100 150 3
BT-6231 Biosensor 3 1 0 50 100 150 3
BT-6711 Nanobiotechnology 3 1 0 50 100 150 3
BT-6721 Environmental
Biotechnology
3 1 0 50 100 150 3
BT-673 Environmental
Biotechnology Lab
0 0 2 30 70 100 2
BT-624 Bioprocess
Engineering Lab
0 0 2 30 70 100 2
BT-674 Minor Project-I 0 0 1 50 - 50 1
TOTAL 360 640 1000 20
Third semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-721 Professional
Elective I
3 1 0 50 100 150 3
BT-722 Professional
Elective II
3 1 0 50 100 150 3
BT-723 Self Study open
area seminar-II
0 0 1 100 100 2
BT-724 Minor Project-II 300 300 6
BT-725 Major Project-I 300 300 6
TOTAL 200 800 1000 20
Fourth semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-821 Major Project-II 400 600 1000 20
TOTAL 1000 20
BT- 721 ELECTIVE SUBJECTS- I
BT-7211 Bioseparation Technology
BT-7212 Industrial waste water treatment
BT-7213 Biopolymer Technology
BT-7214 Bioprocess Plant Designing
BT-7215 Transport Phenomenon
BT-7216 Biochemical Thermodynamics
BT-722 ELECTIVE SUBJECTS- II
BT-7221 Bioethics Biosafety and IPR
BT-7222 Quality Management
BT-7223 Protein Engineering
BT-722 4 Metabolic Engineering
BT-7225 Design and Development of Biological Treatment process
BT-7226 Bioinformatics
SEMESTER I
BT- 521 Bioenergy
Unit-I
Introduction
Global energy scenario Indian energy scenario types of energy sources description of Biofuels
various Biofuels Bioenergy from biomass Biofuel Production Alternative Biochemical Pathways for
Organo-heterotrophic Lithotrophic and Phototrophic Metabolism Importance of biofuel feed stocks
Cellulose starch sugar Lignocellulosic Agro and Industrial by-products
Unit-II
Production of Bio-ethanol
Process Technology for Bioethanol production using Sugar Starch and Lignocellulosic Selection of
micro-organisms and raw materials Unit Operations in Alcohol production Continuous
fermentation Distillery quality control Alcohol distillation
Unit-III
Production of Biodiesel
Chemical Thermodynamic and Reaction Kinetic Aspects of Biodiesel Production Lipids as a source
of biodiesel Methods of Biodiesel Production ndash General procedure and large scale production
Quality Control Aspects Biodiesel production from microalgae and future prospects
Unit-IV
Production of Biohydrogen
Biohydrogen production by anaerobic bacteria and photosynthetic algae Enzymes involved in
biohydrogen Production Biochemical Pathway Batch Fermentation Factors affecting biohydrogen
production Carbon sources Process and Culture Parameters Detection and Quantification of
biohydrogen
Unit-V
Microbial Fuel Cells
Introduction and biochemical basis History of microbial fuel cell development Microbes used in
microbial fuel cells Design of microbial fuel cells MFC components Two and Single MFC systems
Stacked microbial fuel cell Performances of microbial fuel cells Ideal performance Actual MFC
performance Effects of operating conditions pH buffer and electrolyte Proton exchange system
Operating conditions in the anodic chamber Operating conditions in the cathodic chamber
Applications Electricity generation Biohydrogen Wastewater treatment Biosensor MFCs in the
future
Unit-VI
Case studies
Text books
1 Caye M Drapcho NP Nhuan and T H Walker Biofuels Engineering Process Technology Mc
Graw Hill Publishers New York 2008
2 Jonathan RM Biofuels ndash Methods and Protocols (Methods in Molecular Biology Series) Humana
Press New York 2009
3 Lisbeth Olsson (Ed) Biofuels (Advances in Biochemical EngineeringBiotechnology Series
Springer-Verlag Publishers Berlin 2007
BT- 522 Food Engineering and Biotechnology
Unit- I
Food chemistry
Food chemistry-definition and importance Composition of foods and function of water
carbohydrates proteins amino acids lipids vitamins and shelf life of food Bioavailability and
stability of nutrients Nutritive value of foods Food as a source of energy Food Health and diseases
Unit ndash II
Food Microbiology
History and significance of microorganisms in foods Biotechnological improvements catabolic
repression Microbial growth pattern Biochemical changes caused by micro-organisms deterioration
of various types of food product Food poisoning and microbial toxins standards for different foods
Food borne intcericants and mycotoxius
Unit ndashIII
Fermentation products
Dairy products Production of starter cultures Cheese - principles of cheese making Cheddar
Cheese Swiss Cheese Surface ripened Cheeses Mold ripened Cheeses General principles of
manufacture of Kefir Fermented foods Soy sauce Miso Sufu Natto Idli fermented fish products
Fermented vegetables Sauer Krant pickles Olives Fermented sausages Distilled beverages
Alcohol wine brandy and beer Food additives organic acid (acetic acid lactic acid and citric acid)
amino acids (glutamic acid lysine threonine arginine and histidine) food flavourants and pigments
Unit ndashIV
Food Preservation and storage
General principles underlying spoilage and chemical changes of food caused by microorganisms
(Staphylococcal Salmonellosis Ecoli) food spoiling enzymes Botulism toxin production and
deterioration of foods Principles of food preservation by physical methods (irradiation drying heat
processing chilling and freezing high pressure and modification of atmosphere) by chemical
methods and biological methods Storage Stability Food Preservation with Low Temperatures Food
Preservation with High Temperatures Preservation of Foods by Drying Indicator and Food-borne
Pathogens
Unit V
Food process technology
Packaging and canning of foods ndash preparation for packaging thermal processing of foods
Microwave heating thermal inactivation of microorganisms thermal process evaluations freezing
and thawing of foods Food process operations Evaporation single and multi effect evaporation
dehydration psychomatric charts drying-tunnel tray spray drum freeze distillation food
processing aid through biotechnology Food sanitation Good manufacturing practices ndash Hazard
analysis Critical control points Personnel hygiene
Unit ndashVI
Food Processing and Quality assurance
Basic principles unit operations and equipment involved in the commercially important food
processing methods and unit operations materials and containers used in food packaging Objectives
importance and functions of quality control Methods of quality assessment of food materials-fruits
vegetables cereals dairy products meat and poultry Food regulations grades and standards
Concept of Codex AlmentariousHACCPUSFDAISO 9000 series etc Food laws and standards
Text Books
1 Frazier WS and Weshoff DC Food Microbiology 4th Edn McGraw Hill Book Co New
York 1998
2 Mann amp Trusswell Essentials of human nutrition 3rd edition oxford university press 2007
3 Prescott and Dunns Gerald Reed Industrial Microbiology 4th Edition AVI Publishing Company
Inc Conneticut 1983
4 BSivashankar ndash Food processing and preservation Prentice ndash Hall of India PvtLtdNew Delhi
2002
BT- 523 Enzyme Engineering and Technology
Unit-I
Introduction to enzymes
Introduction nomenclature and classification of enzyme Mechanism and catalysis concept of active
site and energetics of enzyme substrate complex formation specificity of enzyme action principles
of catalysis ndash collision theory transition state theory role of entropy in catalysis Biocatalysis in
organic liquids Enzymatic catalysis in biphasic system Ribozyme Abzyme (catalytic antibodies)
Biosynthesis and regulation of enzyme in microorganism
Unit-II
Enzyme Kinetics
Kinetics of substrate and multisubstrate reactions King-Altmanrsquos method Analysis of kinetic data
Inhibition - substrate product and inhibitors Active and legend binding sites Allosteric regulation of
enzymes Monod changeux wyman model deactivation kinetics Molecular folding and defolding of
enzymes
Unit - III
Enzyme immobilization
Methods of immobilization External and internal diffusional mass transfer limitation Effectiveness
factor and modulus electrostatic and stearic effects in immobilized enzyme systems
Unit-IV
Enzyme Reactor
Reactors for Batch continuous enzymatic processing choice of reactor type idealized enzyme
reactor systems Mass transfer in enzyme reactors Steady state analysis of mass transfer and
biochemical reaction in enzyme reactors
Unit ndashV
Purification and Characterization of enzymes from natural source
Production and purification of crude enzyme extracts from plant animal and microbial sources
methods of characterization of enzymes
Unit-VI
Application of enzymes
Application of enzymes in different industries (Pulp and Paper industry Detergent industry Textile
industry Food processing industry) Medical and analytical application of enzyme Biosensor
Text books
1 Enzymes A Practical Introduction to Structure Mechanism and Data Analysis by RA Copeland
Publisher John Wiley and Sons Inc
2 Enzymes by Palmer (2001) Horwood Publishing Series
3 Introduction to Biocatalysis using Enzymes and Microorganisms by SM Roberts NJ Turner and
A J Willetts Publisher Cambridge University Press
4 Fundamentals of Enzymology by Price and Stevens (2002) Publisher Oxford University Press
5 Enzyme Technology by Helmut Uhling (1998) Publisher John Wiley
6 Introduction to Proteins Structure by Branden and Tooze (1998) Publisher Garland Publishing
7 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady - State Enzyme
Systems by IH Segel Publisher Wiley-Interscience
BT-571 Industrial Plant Biotechnology
Unit-I
Plant genome organization
Organization and features of mitochondrial nuclear and choloroplast genome ndash Structural features of
gene families in plants
Unit-II
Plant cell cultivation
Callus cultures cell cultures and protoplast cultures Micropropagation Organogenesis and somatic
embryogenesis Cell suspension culture Ovule culture Anther culture Production of haploids
Protoplast isolation and fusion Selection systems for somatic hybridscybrids Somaclonal variation
Preservation of germplasm Formation of Secondary Metabolites in Tissue Culture Production of
pharmaceuticals by tissue culture pigments perfumes flavors insecticides flavonoids
Biotransformation using plant cell cultures Bioreactor system and models for mass cultivation of
plant cells hairy root culture Quality assurance and quality control
Unit-III
Transgenic plant and application
Transgenesis in plants Gene transfer in plants ndash Gene transfer through vectors - Biology of vectors
used - Ti and Ri plasmids binary vectors viral vectors cloning strategy and method of gene transfer
Vectorless gene transfer ndash electroporation and gene gun method DNA bar coding Application of
transgenic plants Virus resistance coat protein mediated nucleocapsid gene Nematode resistance
Abiotic stress Drought cold and salt Post-harvest losses long shelf life of fruits and flowers use of
ACC synthase polygalacturanase ACC oxidase male sterile lines bar and barnase systems
carbohydrate composition and storage ADP glucose pyrophosphatase RNAi and Reverse genetics
Unit- IV
Natural Resource Management
Different approaches of Biodiversity Conservation Biotechnological Characterization and strategies
for the conservation of different populations of endangered plants Molecular markers and genetic
diversity screening
Unit-V
Plant metabolism Metabolomics and metabolic engineering
General concepts of metabolism Introduction to databases from plant transcriptomics to
metabolomics
Unit VI
Industrial applications
Industries engaged in tissue cultureplant cell suspension culture their working and management
Pharmaseutically useful metabolites generated by suspension cultures
Text books
1 Dixon RA and Gonzales Plant Cell Culture A Practical Approach IRL Press 1995
2 Lindsey K and MGK Jones Plant Biotechnology in Agriculture Prentice Hall New Jersey
1990
3 Biotol series In vitro Cultivation of Plant cell Butterworth Heinemann Ltd 1994
4 Ranga MM Animal Biotechnology (3e) Agrobios 2007
5 Bhojwani amp Rajdhan Animal and Plant Biotechnology Elsevier 1996 )
6 Gene cloning amp DNA Analysis An introduction by T A Brown Fourth edition (2001)
7 Genetic Engineering by S Rastogi and N Pathak Publishers Oxford University Press(2009)
8 Principles of Gene Manipulation amp Genomics by Primrose amp Twyman Seven edition (2006)
BT- 572 Bioinstrumentation
Unit I
Electrochemistry Temperature pH buffers Conductivity Dissolved oxygen carbon dioxide
Unit II
Centrifugation Basic principle and application Analytical and Preparative centrifuges and ultra
centrifugation
Unit III
Electrophoretic Techniques Paper and gel electrophoresis Immuno electrophoresis isoelectric
focussing two-dimensional electrophoresis capillary electrophoresis
Unit IV
Chromatographic Methods Paper TLC gas chromatography gel filtration ion exchange
chromatography affinity chromatography and HPLC FPLC
Unit V
Spectroscopy UVvisible and NIR spectrofluorimetry Atomic absorption spectrophotometryMass
Spectrometry Infrared and Raman SpectroscopyNuclear Magnetic Resonance and Electron Spin
Resonance spectroscopy
Unit VI
Microscopy Principle parts types and functioning of Microscope Optical and Electron
Microscopy Transmission and Scanning Electron Microscopy Tunneling Electron Microscopy
Atomic Force Microscopy Fluorescence microscopy Confocal microscopy
Text books
1 Principles and Techniques of Practical Biochemistry by Keith Wilson and JohnWalker Cambridge
University Press
2 Biophysical Chemistry The conformation of Biological Macromolecules by CRCantor and PR
Schimmel Publisher WH Freeman
Reference books
1 Essentials of Biophysics by P Narayanan Publishers New Age InternationalPublishers
2 Introduction to Spectroscopy by DL Pavia GM Lampman and G S Kriz Publisher Brooks
Cole
3 Physical Chemistry of Macromolecules by C Tanford Publisher John Wileyand Sons Inc
4 Principles of Physical Biochemistry by KE Van Holde Publisher Prentice Hall
BT-524 Lab- Bioinstrumentation 1 Measurement and control of pH 2 Measurement of conductivity of a given sample
3 Measurement of conductivity and dissolved oxygen in given sample
4 Protein quantification
5 Protein separation through electrophoresis
6 Sample preparation for light microscopy and Electron Microscopy
7 Quantification of DNA RNA Lipid Fatty acids
8 Sample analysis through AAS
9 Sample preparation for Fluorescence and Confocal microscopy
10 Isolation of DNA and analysis by gel electrophoresis
BT-573 Lab- Food Engineering and Biotechnology
1 Isolation of industrially important microbes
2 Production of fermented product
3 Comparative studies of ethanol production using different substrates
4 Production of wine
5 Production of citric acid
6 Detection of adulterants in food
7 Mushroom cultivation
8 Bread making
9 Colourant production
10 Studies of different methods of food preservation
11 Estimation of carbohydrates and proteins
BT-574 Self Study Open Area Seminar-I
SEMESTER II BT- 621 Biopharmaceuticals
Unit-I
Drug metabolism Oxidation reduction hydrolysis conjugation Need for developing new drugs
Procedure followed in drug design Molecular modification of lead compounds Prodrug and soft
drugs Physico-chemical parameters in drug design QSAR Active site determination of enzymes
Design of enzyme inhibitors
Unit-II
Pharmacokinetics and Drug discovery
Biotransformation of drugs Preclinical Pharmacokinetics Compartment modelingone compartment
open model two compartment open model multi compartment model non linear kinetics
bioavailability and bioequivalence excretion of drugs pharmacokinetics ndash effects of food and
fasting Substances derived from bacteria plants insects and animals Sources of active principles
Assay systems and models (eg Knock-out Mice) Protein molecular modeling by computer
Docking studies Structure based drug designing using software
Unit-III
Pharmaceutical dosage forms
Dosage Forms and Basic Preparations Excipients for Pharmaceutical Dosage Forms Compressed
tablets wet granulation dry granulation or slugging direct compression tablet formulation coating
capsules sustained action dosage form parental oral liquids ointments recombinant blood products
and therapeutic enzymes hormones of therapeutic interest Pharmaceutical products Analysis and
Control laxatives ndash analgesics ndash non steroidal contraceptives ndash external antiseptics ndash antacids and
other antibiotics ndash biological ndash hormones ndash vitamins - preservation analytical methods and test for
various drugs and pharmaceuticals packaging techniques ndash quality control
Unit-IV
Pharmaceutical products and products of DNA technology
Microbial products - Antibiotics (penicillin streptomycin tetracycline) vitamins probiotics Plant
secondary metabolites - control mechanism and manipulation of pheny-propanoid pathway and
shikimate pathway Tissue culture production of alkaloids flavanoids steroids terpenoids animal
vaccines Pharmaceutical products of DNA technology Therapeutic proteins ndash Insulin human
growth hormone clotting factors interferons interleukins tissue plasminogen activators
erythropoietin DNAseI alginate lyase muteins Production advantages limitations and applications
of monoclonal antibody Oligonucleotides and Gene therapy ras-Antisense therapy gene delivery
system Vector usage strategies for gene therapy Clinical trials
Unit-V
Drug safety evaluation
Strategy and Phasing for Drug Safety Evaluation in the Discovery and Development of
Pharmaceuticals Regulation of Human Pharmaceutical Safety Acute Toxicity Testing in Drug
Safety Evaluation Special Concerns for the Preclinical Evaluation of Biotechnology Products
Immunotoxicology in Pharmaceutical Development The Application of In Vitro Techniques in Drug
Safety Assessment Pharmaceutical Quality Assurance
Unit-VI
Patenting process in drug manufacturing process
Patenting- Patent types The patent application Patenting in biotechnology Preclinical trials Clinical
trials The role and remit of regulatory authorities-The Food and Drug Administration The
investigational new drug application The new drug application European regulations Guides to
good manufacturing practice Formulation and Delivery Issues of Therapeutic Proteins
Biotechnology-Derived Drug Products Formulation Development Stability Testing Filling and
Packaging
Text books
1 Heinrich Klefenz Industrial pharmaceutical biotechnology John Wiley sons 2002
2 Susanna Wu-Pong Yongyut Rojanasakul and Joseph Robinson Biopharmaceutical drug and
design and development Humana Press 2007
3 Gary Walsh Biopharmaceuticals Biochemistry and Biotechnology (2e) John Wiley amp Sons
2003
4 Herbert A Kirst Wu-Kuang Yeh Milton J Enzyme Technologies for pharmaceutical and
biotechnological applications WILEY-VCH Verlag 2003
BT- 6221 Bioprocess Engineering
Unit I
Media design and Sterilization kinetics
Criteria for good medium medium requirements for fermentation processes carbon nitrogen
minerals vitamins and other complex nutrients oxygen requirements medium formulation of
optimal growth and product formation examples of simple and complex media medium
optimization methods ndash Plackett and Burman and Response surface method Thermal death kinetics
of microorganisms batch and continuous heat sterilization of liquid media design of sterilization
equipment-batch and continuous ilter sterilization of liquid media air sterilization
Unit II
Metabolic stoichiometry and energetics
Stoichiometry of cell growth and product formation elemental balances degrees of reduction of
substrate and biomass available electron balances yield coefficients of biomass and product
formation maintenance coefficients energetic analysis of microbial growth and product formation
oxygen consumption ndash steps involved in the transfer of oxygen to broth and heat evolution in aerobic
cultures
Unit III
Growth and Production kinetics
Kinetic models for microbial growth Monod model growth of filamentous organisms product
formation kinetics - leudeking-piret models substrate and product inhibition on cell growth and
product formation Production kinetics Design for single and multiple reaction size comparisons of
single reactor for single reactions multiple reactor systems for single reaction reactions in parallel
in series and seriesparallel reactions of first order Heterogeneous reactions kinetics and mechanism
of heterogeneous non catalytic and catalytic reactions Non ideal flow - residence time distribution
studies CE F and I curves RTD in ideal reactors Models for Non ideal flow ndash zero ndash parameter
model One parameter model and two parameter model
Unit IV
Types and design of bioreactor
Construction material Basic components ndash Agitator aerator valves and steam traps seals stirrer
glands Stirred tank batch bioreactor stirred batch bio reactor for enzymes cell cultures Continuous
Stirred Tank Bioreactor Continuous operation of mixed reactor enzyme reactions in a mixed
reactor substrate inhibition kinetics and product inhibition kinetics chemostat with cell cultures ndash
steady state cell and substrate concentrations and productivity as a function of dilution rate CSTR
with immobilized enzymes operation of CSTR in a constant feed rate policy-simulation for
conversions with and without diffusion limitations chemostat in series Graphical design Plug Flow
and Packed Bed Bioreactor Performance equation with Michelin-Menten kinetics substrate
inhibition and product inhibition plug flow reactor for immobilized enzymes operation of plug flow
reactor in constant feed rate policy simulation for conversion with and without diffusion limitations
Fedndashbatch reactor Applications of fed reactor Fed batch operation of mixed reactor material
balance on cell and substrate Recycle system Chemostat with recycle Biological waste water
treatment Feed forward control of the activated sludge process The Transient Behavior of
Bioreactors Stability analysis Stability of the chemostat Stability of chemostat with substrate
inhibition Operating diagram Transient responses of the chemostat control of the chemostat
Turbidostat operation Nutristat operation
Unit V
Instrumentation and Control
Biochemical process variables and their measurements Control principles and their application in
bioreactors Theory of electrode processes and their applications Measurement and control of pH
temperature dissolved oxygen aeration and agitation redox potential foam etc On-line analysis of
process parameters Introduction to biosensors Transduction principles used in biosensors
Characteristics of biosensors Biosensors based on amperometric potentiometric thermistor FET
fiber optics and bioluminescence Microbial biosensors Fundamentals of digital process control Use
of computer in control and optimization of microbiological processes
Unit VI
Downstream processing
Removal of microbial cells and solid matter foam separation precipitation filtration centrifugation
cell disruptions liquid-liquid extraction chromatography membrane process drying and
crystallization Quality analysis and product formulation - Product appearance product stabilization
shelf life analysis usage specific formulations quality analysis and control
Text books
1 Biochemical Engineering Fundamentals by JE Baily and DF Ollis Publisher McGraw Hill
(1986)
2 Biochemical Engineering by SAiba AE Humphry and NF Millis Publisher University of
Tokyo press(1973)
3 Bioreaction engineering principles by J Nielson and J Villadsen Publisher Plenum Press (1994)
4 Chemical Engineering Design Fourth edition by JM Coulson and JF Richardson Publisher
Butterworth Heinemann(2005)
5 Bioprocess Engineering- Kinetics Mass transport reactors and gene expression by WR Veith
Publisher John Wiley and Sons Inc(1994)
6Bioprocess Engineering Basic Concepts by ML Shuler and F Kargi Publisher Prentice Hall
(1987)
7Bioprocess engineering principles by P Doran Publisher- Academic press (1995)
BT-6231 Biosensor Unit-I
Introduction
A historical perspective Definition and Expanding Needs of Biosensors Advantages and limitations
Biosensor Economics various components of biosensors
Unit-II
Types of Biosensors
Biocatalysts based biosensors bio affinity based biosensors amp microorganisms based
biosensors biologically active material and analyte Types of membranes used in
biosensor constructions
Unit-III
Transducers in Biosensors
Various types of transducers principles and applications Bio- chemi- and lectrochemiluminescence
for fiber-optic biosensors Fluorescence-based fiber-optic biosensors
Unit-IV
Electrical Signal Detection in Biological Systems
Silicon glass and metal electrodes amplifier design Bioelectronic device production
microelectronic fabrication methods as adapted to bioelectronics hard and soft lithography bio-
compatibility of materials Existing types of Biosensors Miniaturisation and micro-systems
including sensing using optical techniques field effect transistors ion-selective and enzymatic
sensitive electrodes as well as impedance monitoring
Unit-V
Kinetic modeling for biosensors
The purpose and practice of modeling The flux equations The flux diagram for the membrane
enzyme electrode Deriving a complete kinetic model Kinetic modeling in other types of
biosensors- Potentiometric enzyme electrodes Optical and photometric biosensors Immunosensors
Unit-VI
Application and Uses of Biosensors
Biosensors in medicine and health care (For glucose monitoring and for DNA analysis Analysis of
the neural cell impulse signal and neural signal processing) biosensors for agriculture and food Low
cost- biosensor for industrial processes for online monitoring biosensors for environmental
monitoring
Text books
1 Rajmohan Joshi Biosensors (1e) Gyan Books 2006
2 Cooper JM and Anthony EG Biosensors (2e) Oxford University Press 2004
3 Turner APF KarubeI and WilsonGS Biosensors Fundamentals and applications Oxford Univ
Press 1990
4 SadanaA Biosensors Kinetics of Binding and Dissociation Using Fractals (1e) Elsevier BV
1995
5 Ashok M and Kim Rogers Enzyme amp Microbial Biosensors Techniques and Protocols (Methods
in Biotechnology) (1e) Humana Press 1998
6 Ashok M and Kim Rogers Affinity Biosensors Techniques and Protocols (Methods in
Biotechnology) (1e) Humana Press 1998
7 Damia Barcelo Biosensors for the Environmental Monitoring of Aquatic Systems Bioanalytical
and Chemical Methods for Endocrine Disruptors (1e) Springer 2009
BT-6711 Nanobiotechnology
Unit-I
Introduction
Nano - definition The fundamental Science behind nanotechnology- electrons atomsand ions
molecules metals biosystems Synthesis and Characterizations of Nanoscale Materials Strategies for
Nano architecture (top down and bottom up approaches) Fabrication Technologies and
Characterizations Self-assembly Systems Basic aspects of Nanofluidics surfactants polymers
emulsions and colloids Nanoscale Artificial Platforms Lipids in Self-assembly Structures
Nanoparticle synthesis in plants bacteria and yeast and its applications
Unit-II
Nano-structured materials
Fullerenes - Properties and CharacteristicsCarbon Nanotubes - Characteristics and Applications
Quantum Dots and WiresGold Nanoparticles Nanopores carbon nanotubes Applications of
NanoMolecules in Biosystems
Unit-III
Structural and functional principles of nanobiotechnology
Structural principle Factors governing biomolecular structure and stability Protein folding Self
assembly Self-organization Molecular recognition and Flexibility of biomaterials Functional
principles of Bionanotechnology Information driven nanoassembly Energetics Role of enzymes in
chemical transformation allosteric motion and covalent modification in protein activity regulation
Structure and functional properties of Biomaterials Bimolecular motors ATP Synthetase and
flagellar motors Traffic across membranes Potassium channels ABC Transporters and
Bactreriorhodapsin Bimolecular sensing Self replication Machine-Phase Bionanotechnology
Unit-IV
Bionanomachines and their Basic
Negligible gravity and inertia atomic granularity thermal motion water environment and their
importance in bionanomachines The role of proteins amino acids nucleic acids lipids and
polysaccharides in modern biomaterials Overview of natural Bionanomachines Thymidylate
Sythetase ATP synthetase Actin and myosin Opsin Antibodies and Collagen
Unit-V
Biophotonics and Bioimaging
Overview of imaging biological systems from the cellular level through to wholebody medical
imaging Introduction to biophysics basic physical concepts in imaging Major techniques using
ionizing and non-ionizing radiation fluorescence and multi-photon microscopy spectroscopy OCT
MRI X-ray CT PET and SPECT imaging
Unit-VI
Application of Nanobiotechnology
Nano-biotechnology in drug Delivery Nanoscale Devices for Drug Discovery Micelles for Drug
Delivery Protein targeting Small Molecule-Protein Interactions Micro-array and Genome Chips
Nanotechnology and the Cell Cell Motility Nano Motors and Cellular Navigation hemotaxis -
Transmembrane Signalling and Related Protein Nanotechnology for Cancer Diagnostics and
Treatment Nanotechnology for Cancer Research and Therapy siRNA Tumor-targeted Drug
Delivery Systems Nanotechnology for Imaging and Detection
Text Books
1 NANO by TPradeep 2006Tata Mc Graw Publishers India
2 Nanobiotechnology Concepts Applications and Perspectives Christof MNiemeyer Chad
AMirkin (eds) Wiley-VCH Weinheim (2004)
3 Kamali Kannangara Geoff Smith Michelle Simmons Burkhard Raguse
4 Overseas Press (2005)
5 David S Goodsell Bionanotechnology John Wiley amp Sons 2004
6 Greco Ralph S Nanoscale Technology in Biological Systems CRC Press 2005
BT-6721 Environmental Biotechnology
Unit-I
Basic concepts of ecology Interaction between environment and biota Concept of habitat and
ecological niches Limiting factor Energy flow food chain food web and trophic level NPC and S
cycles in nature Ecosystem dynamics and management Environmental impact assessment
Principles of conservation Conservation strategies sustainable development Global environmental
problems ozone depletion UV-B radiation green house effect and acid rain their impact in
biotechnological approaches for management
Unit-II
Environmental pollution
Types of pollution and pollution analysis ndash noise air and gaseous pollution Noise pollution Source
measurement impact on ecosystem and control Air pollution Types source method of sampling
measurement impact on ecosystem and control Control of noise and air pollution by
biotechnological methods Gaseous pollutants and odours General sources methods of control
fundamentals of adsorption mechanism of adsorption equilibrium isotherms break through curve
adsorption equipment regeneration of adsorbent application of adsorption for control of gaseous
and odour emission
Unit-III
Water pollution Impurities in water water pollution by industrial waste examination of water
collection of water samples water analysis ndash physical chemical and biological Standards of water
quality Water treatment processes Primary treatment screening skimming with coagulants
flocculation filteration aeration and disinfection Secondary treatment Aerobic processes ndash
activated sludge oxidation ditches recirculating system trickling filter towers rotating discs
rotating drums oxidation ponds Anaerobic digestion anaerobic filters Up flow anaerobic sludge
blanket reactors Tertiary treatment Activated carbon treatment reverse osmosis and electro dialysis
Unit-IV
Bioremediation
In situ and ex situ bioremediation technologies for various pollutants and sites bioremediation of oil
spills and heavy metal pollution use of microbes in bioremediation hydroponic system pollution
control boards and pollution control acts
Unit-V
Solid waste management sewage sludge treatment and utilization refuse disposal excreta disposal
in unsewered area composting and vermiculture biodegradation of noncellulosic wastes for
environmental conservation and fuel bioconversion of cellulosic wastes into protein and fuel
bioremediation of contaminated soils and waste lands radioactive product waste disposal
Unit-VI
Effluent treatment Sources of pollution impact on ecosystem and treatment of following industrial
effluents starch paper and pulp tannery dairy distillery oil refineries and pharmaceutical
Microbes in mining ore leaching oil recovery biopolymers biosurfactants
Text Books
1 Bruce E Rittmann and perry L Mccarty ldquoEnvironmental Biotechnology Principle and
Applicationsrdquo McGraw Hill publishing company Ltd2001
2 Mecalf and Eddy Inc ldquoWastewater Engineering Treatment Disposal Reuserdquo McGraHill
publishing company Ltd1991
3 Des W Connell ldquoBasic concepts of Environmental chemistryrdquo Lewis publishers2005
4 Michal J PelczarECS ChanNoel RKriegTata McGraw Hill publishing company Ltd1993
5 Alan Scragg Environmental BiotechnologyOxford University press2005
6 Prescott Harley Klein Microbiology WCB publishers1996
7 Richard T Wright and Bernard J Nebel ldquoEnvironmental Science towards a Sustainable Futurerdquo
Prentice Hall of India 2004
BT-624-Bioprocess Engineering Lab
1 To determine the concentration of protein content by Lowry method
2 To determine the concentration of sugar by 3 5 dinitrosalicylic acid method
3 To determine the optimum pH for given enzyme sample
4 To determine the optimum temperature for given enzyme sample
5 To study the immobilization of invertase enzyme
6 Measurement of citric acid production by Aspergillus niger with TLC
7 Determination of thermal death point (TDP) of the given microorganism
8 Production of ethanol from yeast fermentation of sugars
9 To prepare the growth curve of micro-organism cultured in a shake flask
10 To study the kinetics of lipase enzyme
BT-673- Environmental Biotechnology Lab 1 Environmental Impact Assessment Measurement of Air and Noise Pollution
2 Analysis of water temperature and pH
3 Measurement of Conductivity and TDS in water
4 Measurement of Dissolved Oxygen
5 Measurement of Carbondi Oxide and Hardness of water
6 Measurement and analysis of Ammonia and Ammonium in water
7 Measurement of Nitrite Nitrate and Total Nitrogen in water
8 Biochemical Oxygen Demand and Chemical Oxygen Demand measurements and analysis
9 Analysis of any one industrial effluent
10 Production of methane from sewage sludge
11 Vermicomposting
BT-674 Minor Project- I
SEMESTER III
BT-721 1 Elective ndash Bioseparation Technology Unit- I
Role of Downstream Processing in Biotechnology
Role and importance of downstream processing in biotechnological processes Problems and
requirements of bioproduct purification Economics and downstream processing in Biotechnology
Cost cutting strategies characterstics of biological mixtures process design criteria for various
classes of bioproducts (high volume-low value products and low volume- high value products)
physicochemical basis of bioseparation processes
Unit- II
Primary Separation and Recovery Processes
Cell disruption methods for intracellular products removal of insolubles biomass (and particulate
debris) separation techniques flocculation and sedimentation centrifugation and filtration methods
Precipitation methodsPrecipitation with salts organic solvents amp polymers
Unit- III
Extraction
Batch extractions staged extractions-cross current co current counter current extractions
Differential extractions fractional extractions with a stationary phase fractional extractions with two
moving phases Aqueous two-phase extraction reverse micelle extraction supercritical fluid
extraction in-situ product removalintegrated bioprocessing
Unit- IV
Membrane-based separations (micro- and ultra-filtration)
Theory design amp configuration of membrane separation equipment applications
reverse osmosis dialysis electro dialysis Isoelectric focusing
Unit- V
Adsorption
Adsorption isotherms industrial adsorbents adsorption equipments for batch and continuous
operations (co current and counter current) adsorption in fixed beds
Unit- VI
Chromatography
Principles of chromatographic separation ndash gel filtration reversed phase hydrophobic interaction
ion-exchange expanded bed adsorption bio affinity and IMAC supercritical fluid chromatography
Text books
1 Belter PA Cussler E and Wei Shan Hu Bioseparation ndash Downstream Processing for
Biotechnology Wiley Interscience 1988
2 Asenjo and Juan A Asenjo Separation Processes in Biotechnology CRC Press 1990
3 Wankat PC Rate Controlled Separation Kluwer Publishers 1990
4 Wang DIC Cooney CL Demain AL DunnilP Humphery AE and Lilly MD Fermentation
and Enzyme Technology John Wiley and Sons 1979
BT-721 2 Elective - Industrial Waste water treatment
UNIT I
Waste disposal management Methods of waste disposal industrial waste (solid liquid and gaseous
emission) effect of industrial wastes on streams and sewerage systems Treatment system of waste
disposal eg Incenerator differences in waste quality and quantity physico-chemical and biological
treatments of waste and their evaluation in respect of treatment
UNIT II
Characteristic features of wastes (solid liquid and gaseous emission) manufacturing processes and
toxic byproducts generated from iron ore alumina heavy metals units paper and pulp industries
pesticides industry thermal power station distillery textile and crude oil industry
UNIT III
Small and large scale industries for waste reduction and remediation various methods for waste
alteration volume and strength minimization recycling plants material restoration and conservation
Methods for neutralisation equalization precipitation and solidification for waste handling
Economic sustainability and government support for joint treatment of raw effluent municipal
sewage and debris
UNIT IV
Unit operations and their design for treatment and management of wastes (solid liquid and gaseous)
UNIT V
Landfill design and operation including site selection engineered sites liners and covers leachate
control and treatment gas recovery and control including utilization of recovered gas (energy) and
landfill monitoring and reclamation
UNIT VI
Case studies
Text Books
1 S P Mahajan ldquoPollution Control in Process Industriesrdquo Tata Mc Graw Hill Publications
2 W Wesley Eckenfelder Jrrdquo Industrial Water Pollution Controlrdquo Mc Graw Hill Publications
3 Ronald W Crites Sherwood C Reed and Robert Bastion ldquoLand Treatment Systems for Municipal
amp Industrial Wastesrdquo Mc Graw Hill Publications
4 Neal K Ostler ldquoIndustrial Waste Stream Generationrdquo Prentice Hall
5 Rao and Dutta ldquoIndustrial waste treatmentrdquo Oxford and IBH Publishing Co Pvt Ltd New Delhi
6 Dr A D Patwardhan ldquoindustrial Waste Water Treatmentrdquo Prentice Hall of India
BT-721 3 Elective-Biopolymer Technology Unit-I
Introduction
Biopolymers ndash The current scenario different biopolymers ndash produced from various renewable
resources characteristics merits and demerits over conventional polymers
Unit-II
Biopolymer Technology and Applications
Biopolymers and Artificial Biopolymers in Biomedical Applications an Overview Novel Synthesis
of Biopolymers and Their Medical Applications Composite Films Based on Poly (Vinylalcohol) and
Lignocellulosic Fibres Preparation and Characterizations Composite Materials Based on Gelatin
and Fillers from Renewable Resources Thermal and Mechanical Properties Properties of PHAs and
Their Correlation to Fermentation Conditions
Unit-III
Biosynthesis and Modifications
Synthesis and modification of different Biopolymers like xanthum gum
Unit-IV
Biosurfactants
Source characteristics and properties of Biosurfactants Production of Biosurfactants via the
fermentation and biotransformation routes Production of Biosurfactants with immobilized cells
Integrated bioprocess for continuous production of Biosurfactants including downstream processing
Applications of Biosurfactants-Food Industry Environmental Control
Unit-V
Bioplastic
Different types of bioplastics Starch-based plastic Cellulose-based plastic Aliphatic polyesters
Poly-3-hydroxybutyrate (PHB) Polylactic acid (PLA) Polyamide Bio-derived polyethylene
Advantages of bioplastic over petroleum-based polymer Mechanism of synthesis of Poly (-
hydroxybutyric acid) (PHB)
Unit-VI
Material Testing and Analytical Methods
An Overview of Available Testing Methods Comparison of Test Systems for the Examination of the
Fermentability of Biodegradable Materials Structure- Biodegradability Relationship of biopolymers
Text Books
1 Emo Chiellini Emo Chiellini and Helena Gil Biorelated Polymers Sustainable Polymer Science
and Technology Springer 2001
2 Johnson RM LY Mwaikambo and N Tucker Biopolymers Rapra Technology 2003
3 Naim Kosaric (Ed) Biosurfactants Marcell Dekker Inc 1993
BT-721 4 Elective ndash Bioprocess Plant Designing Unit-I
Process development
Introduction to Design ndash nature of design ndash Technical feasibility survey Mass and energy balance
process development ndash data acquisition ndash design data information of project - Organization of project
ndash Project documentation ndash codes and standards
Unit-II
Design Development
Equipment selection and specifications-materials of construction ndash flow sheeting - piping and
instrumentation ndash process safety and loss prevention
Unit-III
General site consideration
Introduction ndash plant location and site selection ndash site layout- plant layout utilities ndash environmental
considerationsndash waste management ndash visual impact ndash government regulations and other legal
restrictions community factors and other factors affecting investment and production costs ndash human
resources
Unit ndashIV
Selection and specification
Selection and specification of equipment for handling fluids and solids Selection specification
design of heat and mass transfer equipment used in bioprocess industries Design of facilities for
cleaning of process equipment used in biochemical industries Utilities for biotechnology
Unit-V
Design of fermenters
Design of fermentation Design considerations for maintaining sterility of processing equipment
Unit-VI
Process economics
Production plants Bioprocess validation Safety considerations
Text books
1 Applied Process Design for Chemical and Petrochemical Plants by EE Ludwig Publisher
Butterworth-Heinemann
2 Chemical Engineering by RK Sinnott JM Coulson and JF Richardsons Publisher
Butterworth-Heinemann Vol-6 Butterworth Heinemann III editionndash 2002
3 Peters and Timmerhaus Plant Design and Economics for Chemical Engineers Mcgraw Hill
4thEdition 1989
4 Rudd and Watson Strategy of Process Engineering Wiley 1987
BT-721 5 Elective- Transport Phenomenon Unit -I
Diffusion
Molecular and turbulent diffusion Diffusion coefficient Flickrsquos Law of diffusion Dependence of
diffusion coefficient on temperature pressure and composition Diffusion in multi-component gas
mixtures Diffusion in solids Molecular Knudsen ampsurface diffusion Inter- phase mass transfer
Mass transfer coefficients Diffusion between phases Equilibrium solubility of gases in liquids
Mass Transfer theories Mass transfer in fluidized beds flow past solids and boundary layers
Simultaneous heat and mass transfer Mixing in a Bioreactor -Flow regimes with and without baffles
various types of impellers and mixing equipment Power Requirements for Mixing Ungassed
Newtonian Fluids Gassed Fluids Improving Mixing in Fermenters Effect of Rheological Properties
on Mixing Role of Shear in Stirred Fermenters
Unit-II
Drying and Crystallization
Solid-gas equilibria Different modes of drying operation Types of batch and continuous dryer
Definitions of moisture contents Rate of batch drying Time of drying Mechanism of batch drying
Continuous drying Equilibrium yield of crystallization Heat and mass transfer rates in
crystallization Theories of crystallization Factors governing nucleation and crystal growth rates
controlled growth of crystal Classification of crystallizers
Unit ndashIII
Absorption and Adsorption
Gas-Liquid equilibriaHenryrsquos Law Selection of solvents Absorption in tray column Graphical and
analytical methods Absorption in packed column Design equation for packed column HTU NTU
and HTEP concepts Equipments Description of adsorption process and their application Types of
adsorption Nature of adsorbents Adsorption equilibrium and adsorption hysterises Stage wise and
continuous contact adsorption operation operations Determination of number of stages Equipments
Unit-IV
Momentum transfer
Review of basic concepts ndash Conservation of Mass Conservation of Energy Momentum Balance ndash
Momentum Balance in a Circular Pipe Flow Velocity Profile Fermentation Broth Rheology ndash
Viscosity Rheological Properties of Fermentation Broths Factors affecting broth viscosity
Unit V
Conduction and Convection
Introduction Conduction Basic concepts of conduction in solids liquids and gases One and two
dimensional heat conduction Critical and optimum insulation thickness Introduction to unsteady
state heat transfer Principles of convection Equations of forced and free convection
Unit ndashVI
Radiation
Basic laws of heat transfer by radiation black body and gray body concepts solar radiations
combined heat transfer coefficients by convection and radiation Introduction of Heat Transfer
Equipments Heat Exchangers Evaporators Condenser
Text Books
1 Holman JP ldquoHeat Transferrdquo 9 th ed McGraw Hill (1989)
2 Treybal R ldquoMass Transfer Operationsrdquo 3rd ed New York McGraw-Hill (1980)
3 McCabe Smith Unit Operations in Chemical Engineering McGraw Hill
4 Foust A S etal ldquoPrinciples of Unit Operationsrdquo John Wiley (1980)
5 R B Bird et al Transport Phenomena 2nd Edition Wiley(2006)
BT-721 6 Elective ndash Biochemical thermodynamics Unit-I
Fundamental concepts of Thermodynamics
System and Surroundings First law of thermodynamics -Internal energy enthalpy Heat capacity
applied examples from biochemistry Second law ndash Entropy and universe Concept of heat engines
protein stability and calorimetric measurements Fundamentals of Differential scanning calorimeter
and Isothermal calorimeter in biological property measurements Third law of thermodynamics
Maxwell equations Gibbs-Duhem Equation and the Phase Rule Legendre Transforms
Unit-II
Non-equilibrium Thermodynamics
Reversible work exact differentials and function of state first and second law The electrochemical
potential External forces and steady state Fickrsquos Law chemical reactions in the steady state internal
entropy production cells as non-equilibrium stationary states Diffusion and membrane transport
Biological Systems as Open Non-equilibrium Systems Failure of classical thermodynamics in
describing biological processes Standard free energy changes and equilibrium constants direction
and rate
Unit-III
Bioenergetics
Energetics of metabolic pathways ndash energy coupling (ATP amp NADH) stoichiometry ndashenergetic
analysis of cell growth and product formation ndash elemental balances Degree ofreduction concepts
available- electron balances yield coefficients oxygen consumptionand heat evolution in aerobic
cultures thermodynamic efficiency of growth Thermodynamics of Biological Systems
Thermodynamic analysis of oxidative photophosphorylation stability of non-equilibrium stationary
states ordering in time and space far from equilibrium glycolytic oscillations Biological clocks
routes to chaos
Unit-IV
Chemical Potential
Visualization of the potential Steady velocity and steady flow Fickrsquos law and diffusion Local
Equilibria and Steady State Energy vs Power Transducers in biological states Constitutive
equations Dynamic efficiency and Onsager (nonequilibrium thermodynamics) Prigoginersquos principle
Spontaneous coupling and entropy production
Unit-V
Gibbs free energy and its Applications
Gibbs free energy and equilibrium Chemical potential ionic solutions Equilibrium constant
standard state in biochemistry Acid and bases chemical coupling and redox reactions Gibbs free
energy in photosynthesis glycolysis citric acid cycle Oxidative phosphorylation and ATP
hydrolysis substrate cycling Membrane transport Enzyme substrate interaction Haemoglobin
Protien solubility stability and dynamics
Unit-VI
Reaction Kinetics
Rate of a reaction rate constant and order of the reaction effect of temperature collision and
transition state theory Electron transfer kinetics Enzyme kinetics and inhibition Reaction
mechanism of lysozyme protein folding and pathological misfolding polymerisation muscle
contraction and the molecular motors
Text Books
1 Smith JM Van Ness HC Abbot MM Chemical Engineering Thermodynamics 6th Edition
McGraw-Hill 2001
2 Narayanan KV A Text Book Of Chemical Engineering Thermodynamics Prentice Hall India
2001
3 Sandler SI Chemical And Engineering Thermodynamics John Wiley1989
4 Bailey amp Ollis Biochemical Engineering Fundamentals II edition Megraw Hil ndash 1986
5 Donald T Haynie Biological Thermodynamics Cambridge press 2008
6 Robert A Alberty Thermodynamics of Biochemical Reactions John willy publications 2003
7 Bioenergetics by AL Lehninger Publisher WA Benjamin Inc
8 Biological Thermodynamics by DT Haynie Publisher Cambridge University Press
9 Biophysical Chemistry by CR Cantor and PR Schimmel Publisher
10 FreemanThermodynamics and Kinetics for the Biological Sciences by GG Hammes Publisher
John Wiley and Sons Inc
BT-7221 Elective - Bioethics Biosafety and IPR Unit I
Introduction to ethics and bioethics
Personal ethics profession and professionalism -Moral Reasoning -Ethical theories - person as an
experimenter -Moral leadership (integrity and ingenuinity) ndash framework for ethical decision making
Biotechnology and ethics Biotechnology in agriculture and environment benefits and risks ndash
benefits and risks of genetic engineering ndash ethical aspects of genetic testing ndash ethical aspects relating
to use of genetic information ndash genetic engineering and biowarfare
Unit-II
Ethical implications of cloning
Reproductive cloning therapeutic cloning Ethical legal and socio-economic aspects of gene
therapy germ line somatic embryonic and adult stem cell research- GM crops and GMO‟s ndash
biotechnology and biopiracy ndash ELSI of human genome project
Unit-III
Introduction to biosafety
Biosafety issues in biotechnology ndash risk assessment and risk management ndash safety protocols risk
groups ndash biosafety levels ndash biosafety guidelines and regulations (National and International) ndash
operation of biosafety guidelines and regulations ndash types of biosafety containment International
guidelines with regard to rDNA technology transgenic science GM crops etc Experimental
protocol approvals levels of containment Guidelines for research in transgenic plants Good
manufacturing practice and Good lab practice (GMO and GLP)
Unit-IV
Introduction to intellectual property and intellectual property rights
Types patents copy rights trade marks design rights geographical indications ndash importance of IPR
ndash patentable and non patentables ndash patenting life ndash legal protection of biotechnological inventions ndash
world intellectual property rights organization (WIPO) Plant breederrsquos rights Legal implications
Biodiversity and farmers rights Examples of patents in biotechnology Special application of patent
laws in biotechnology Licensing and cross licensing Flavr SavrTm- Tomato as model case and case
studies
Unit-V
Public acceptance issues for biotechnology
Environmental aspects of biotech application Use of genetically modified organisms and their
release in environment Case studies or experiences from developing and developed countries
Biotechnology and hunger Challenges for the Indian Biotechnological research and industries
Unit-VI
Socioeconomic impacts of biotechnology
The legal and socioeconomic impacts of biotechnology public education of the processes of
biotechnology involved in generating new forms of life for informed decision making
Text Books
1 Ethics in engineering Martin MW and SchinzingerR III Edition Tata McGraw- Hill New
Delhi 2003
2 Biotechnologies and Development UNESCO Publications 1988
3 A Biotechnologies in developing countries present and future UNESCO Publishers 1993
4 Singh K Intellectual property rights on Biotechnology BCIL New Delhi
BT-722 4 Elective ndash Metabolic Engineering Unit ndash I
Cellular metabolism
An overview of cellular metabolism-transport processes- Fueling reactions -glycolysis-fermentative
pathways-TCA cycle and oxidative phosphorylation-anaplerotic pathways -catabolism of fats
organic acids and amino acids -biosynthetic reactions of amino acids ndash nucleic acids fatty acids and
other building blocks -polymerization - growth energetics
Unit ndash II
Comprehensive models for cellular reactions
Stoichiometry of cellular reactions -reaction rates-dynamic mass balances-Yield coefficients and
linear rate equation Material Balance and data consistency ndashblack box model elemental balance -
heat balance -analysis of over determined systems - identification of gross measurement errors
Unit ndash III
Regulation of metabolic pathways
Overview of enzyme kinetics ndash simple reversible inhibition systems ndash irreversible inhibition ndash
allosteric enzymes cooperativity ndash regulation of enzyme concentration ndash transcription initiation ndash
translation regulation at whole cell level ndash regulation of metabolic networks enhancements of
product yield and productivity for ethanol and amino acids pathways metabolic pathway
manipulations to extend substrate range product spectrum and novel products improvement of
cellular properties
Unit ndash IV
Metabolic flux analysis
Theory ndash overdetermined systems ndash underdetermined systems ndash sensitivity analysis ndash methods for the
experimental determination of metabolic fluxes by isotope labeling direct flux determination from
fractional enrichment ndash applications involving complete enumeration of metabolite isotopomers ndash
carbon metabolite balances Applications of metabolic flux analysis ndash amino acid production by
Glutamic acid Bacteria
Unit ndash V
Metabolic control analysis
Fundamentals of Metabolic control analysis -determination of flux control coefficients ndash MCA of
Linear pathways ndash branched pathways ndash theory of large deviation
Unit-VI
Applications of metabolic engineering
Text Books
1 Gregory N Stepanopoulos Aristos A Aristidou Jens Nielsen Metabolic Engineeing
2 Principles and methodologies Academic Press 1998
3 Wang DIC Cooney CL Demain AL DunnilP Humphery AE Lilly MD
4 ldquoFermentation And Enzyme Technologyrdquo John Wiley And Sons 1980
5 Zubay G ldquoBiochemistryrdquo Macmillan Publishers 1989
BT-722 3 Elective ndash Protein Engineering Unit-I
Bonds and Energies in protein
Covalent Ionic Hydrogen Coordinate hydrophobic and Vander walls interactions in protein
structure Interaction with electromagnetic radiation (radio micro infrared visible ultraviolet X-
ray) and elucidation of protein structure
Unit-II
Amino acids and their characteristics
Amino acids ndash structure with three and single letter codes- molecular properties (size solubility
charge pKa) Chemical reactivity in relation to post-translational modification (involving amino
carboxyl hydroxyl thiol imidazole groups) and peptide synthesis
Unit - III
Protein architecture
Primary structure peptide mapping peptide sequencing - automated Edman method amp massspec
High-throughput protein sequencing setup Secondary structure Alpha beta and loop structures and
methods to determine Super-secondary structure Aphaturn- alpha beta-turn-beta (hairpin) beta-
sheets alpha-beta-alpha topology diagrams up and down amp TIM barrel structures nucleotide
binding folds prediction of substrate binding sites Tertiary structure Domains folding denaturation
and renaturation overview of methods todetermine 3D structures Quaternary structure Modular
nature formation of complexes
Unit-IV
Structure-function relationship
DNA-binding proteins prokaryotic transcription factors Helix-turn-Helix motif in DNA binding
Trp repressor Eucaryotic transcription factors Zn fingers helix-turn helix motifs in homeodomain
Leucine zippers Membrane proteins and receptors bacteriorhodopsin and Photosynthetic reaction
center Immunoglobulins IgG Light chain and heavy chain architecture abzymes and Enzymes
Serine proteases understanding catalytic design by engineering trypsin chymotrypsin and elastase
substrate-assisted catalysis other commercial applications
Unit -V
Identification and analysis of proteins
Identification and analysis of proteins by 2D analysis Spot visualization and picking Tryptic
digestion of protein and peptide fingerprinting Mass spectrometry ion source (MALDI spray
sources) analyzer (ToF quadrupole quadrupole ion trap) and detector
Unit-VI
Tools in proteomics and genomics
Site directed mutagenesis for specific protein function Basic concept for designing a new
proteinenzyme molecule Specific examples of enzyme engineering Tryesyl t RNA synthetase
Dihydrofolate reductase Subtilisin Advantages ndash protein data base analysis ndash methods to alter
primary structure of proteins examples of engineered proteins thermal stability of T4-lysozyme
recombinant insulin to reduce aggregation and inactivation de novo protein design ndash principles and
examples
Text Books
1 Voet D and Voet G Biochemistry Third edn John Wiley and Sons 2001
2 Moody PCE and Wilkinson AJ Protein Engineering IRL Press Oxford UK 1990
3 Branden C and Tooze J Introduction to Protein Structured Second Edition GarlandPublishing
NY USA 1999
4 Creighton TE Proteins Freeman WH Second Edition 1993
BT-7222 Elective ndash Quality Management Unit-I
Quality Concepts
Definition of Quality Dimensions of Quality Quality Planning Quality costs ndash Analysis
Techniques for Quality Costs Evolution of Quality Control Basic concepts of Total Quality
Management Historical Review Leadership ndash Concepts Role of Senior Management Quality
Council Quality Statements Strategic Planning Deming Philosophy Barriers to TQM
Implementation Control on Purchased Product Procurement of various products evaluation of
supplies capacity verification Development of sources procurement procedure Manufacturing
Quality Methods and techniques for manufacture inspection and control of product quality in sales
and services guarantee analysis of claims
Unit-II
Quality Management
Organization structure and design quality function decentralization designing and fitting
organization for different type products and company economics of quality value and contribution
quality cost optimizing quality cost seduction program Human Factor in quality Attitude of top
management cooperation of groups operators attitude responsibility causes of apparatus error and
corrective methods
Unit-III
Control Charts
Theory of control charts measurement range construction and analysis of R charts process
capability study use of control charts
Attributes of Control Chart
Defects construction and analysis of charts improvement by control chart variable sample size
construction and analysis of C charts
Unit -IV
Defects diagnosis and prevention defect study identification and analysis of defects correcting
measure factors affecting reliability MTTF calculation of reliability building reliability in the
product evaluation of reliability interpretation of test results reliability control maintainability zero
defects quality circle
Unit-V
Statistical process control
The seven tools of quality Statistical Fundamentals ndash Measures of central Tendency and Dispersion
Population and Sample Normal Curve Control Charts for variables and attributes Process
capability Concept of six sigma New seven Management tools
Unit-VI
Quality system
Need for ISO 9000 and Other Quality Systems ISO 90002000 Quality System ndash Elements
Implementation of Quality System Documentation Quality Auditing QS 9000 ISO 14000 ndash
Concept Requirements and Benefits
Text Books
1 Lt Gen H Lal ldquoTotal Quality Managementrdquo Eastern Limited 1990
2 Greg Bounds ldquoBeyond Total Quality Managementrdquo McGraw Hill 1994
3 Menon HG ldquoTQM in New Product manufacturingrdquo McGraw Hill 1992
4 Dale HBesterfiled et at Total Quality Management Pearson Education Asia 1999
5 James REvans amp William MLidsay The Management and Control of Quality (5thEdition)
South-Western (Thomson Learning) 2002 (ISBN 0- 324-06680-5)
6 FeigenbaumAV ldquoTotal Quality Management McGraw-Hill 1991
7 OaklandJS ldquoTotal Quality Management Butterworth ndash Hcinemann Ltd Oxford 1989
8 Narayana V and Sreenivasan NS Quality Management ndash Concepts and Tasks New Age
International 1996
9 Zeiri ldquoTotal Quality Management for Engineers Wood Head Publishers 1991
BT-722 5 ElectivendashDesign and Development of Biological Treatment process
Unit-I
Bacterial metabolism in wastewater treatment systems
Introduction decomposition of organic carbon compounds in natural and manmade systems aerobic
and anaerobic decomposition of glucose protein carbohydrates proteins lipids etc Nitrogen
removal during treatment enhanced biological phosphate removal biological removal bio-
transformations and biosorption of metal ions aerobic and anaerobic degradation of xenobiotics
Unit-II
Activated sludge process
Single and two stage process special developments technological and microbiological aspects plant
configurations design
Unit-III
Modeling of aerobic waste water treatment process
Introduction purpose of modeling activated sludge model presentations waste water characteristics
various disinfection methods for waste water
Unit-IV
High rate anaerobic waste water treatment
Introduction basic principles reactor design parameters reactor operation
Unit-V
Biological Nutrient removal
Suspended growth and attached growth nutrient removal processes and design criteria ndash Nitrogen
(Nitrification and denitrification) and Phosphorus precipitation biological) Biological removal of
toxic and recalcitrant organic wastes
Unit-VI
Water reuse
Wastewater reclamation risk assessment various reclamation technologies storage agricultural
reuse industrial reuse groundwater recharge
Text book
1 Joumlrdening HJ and JWinter Environmental Biotechnology - Concepts and Applications
Cambridge University Press 2006
2 George Tchobanoglous and Franlin L Burton Wastewater Engineering- Treatment Disposal and
Reuse Tata McGraw Hill Publishing Co Ltd 1990
BT-722 6 Elective ndash Bioinformatics
Unit I
Introduction to Biological Databases Types Overview of Biological Databases and Retrieve
Nucleic acid databases NCBI PubMed Entrez Blast OMIM Books Taxonomy Structure
Locuslink Protein Databases- Primary Functional Composite Secondary Structural classification
database Sequence Formats amp storage Sequence submission to sequence Database
Unit II
Genomics Structure of DNA Polymorphisms in DNA Sequence Human Genome Project
Complete Genome Sequences Functional Annotation
Unit III
Human Genetic Variation Databases and Concepts Introduction Forms and mechanisms of
genetic variation Databases of human genetic variation SNP databases Mutation databases Genetic
marker and microsatellite databases Nonnuclear and somatic mutation databases Tools for SNP and
mutation visualization
Unit IV
Biological Sequence Analysis amp Characterization Predictive Functional Analysis of coding and
non-polymorphisms Amino Acid Properties and Consequences of Substitutions
Unit V
Genetics Genomics Interfaces Technologies for the measurement of gene expression The Cancer
Genome Anatomy Project (CGAP) The Human Transcriptome Map Protein Interaction Networks
Computational methods for pathways and systems biology databases and web resources
Unit VI
Soft computation Neural Networks and Machine learning support vector machines fuzzy logic
evolutionary computing genetic algorithms- applications to data mining and bioinformatics
Text Books
1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves Noah Hardy
ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd
2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-81-8318minus831minus9
Himalaya Publication House Discovering Genomics Proteomics and Bioinformatics Campbell
ISBN978813171 5598 Pearson Education
3 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya Publication House
4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978- 3-527-30541-4
John Wiley amp Sons India Pte Ltd
5 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003
6 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor Laboratory 1st edition
2004
7 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by Andreas D
Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition 2004
8 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st edition (2003)
9 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer Pearson education
First edition (2004)
BT-723 Self Study Open Area Seminar-II
BT-724 Minor Project- II
BT-725 Major Project- I
SEMESTER IV
BT-821 Major Project- II
Scheme of Examination and Syllabus
MTech in Industrial Biotechnology
Department of Biotechnology Delhi Technological University
Bawana Road New Delhi -110042
MTech in Industrial Biotechnology Biotechnology Industry Organization (BIO) USA has mentioned three major waves in the field of
biotechnology The first wave Green Biotechnology refers to agricultural biotechnology The
second wave Red Biotechnology refers to pharmaceutical and medical biotechnology while the third
wave White Biotechnology refers to industrial biotechnology Industrial biotechnology is mainly
based on biocatalysis (the use of enzymes and cells to catalyse chemical reactions) and fermentation
technology (directed use of micro-organisms) in combination with recent breakthroughs in the
forefront of molecular genetics and metabolic engineering It includes manufacturing of antibiotics
(cephalosporins streptomycin penicillin) food (yoghurt cheese single cell protein mushroom
probiotics) renewable energy (bioethanol biodiesel biohydrogen) health care (growth hormone
antibodies) biopolymers (polyhydroxy butyrate polylactic acid) enzymes (protease lipase amylase
cellulase pectinase xylanase) in various industries (pulp and paper detergent textile food
processing industry) Industrial biotechnology also involved in bioremediation microbial
degradation of pollutants (hydrocarbons polychlorinated biphenyl polyaromatic hydrocarbons)
Biological waste water treatment is undoubtedly one of the most important biotechnological
processes which have been used to treat municipal waste and industrial waste water The proposed
syllabus has been developed to address the need of well trained industrial biotechnologist cutting
edge RampD for this field The trained manpower will be well versed in techniques of protein science
bio-catalysis engineering biosynthesis microbial manufacturing engineering biological systems and
bio-process engineering Moreover they can easily implement these hands on training in industry to
increase the yield more accurately
Delhi Technological University Delhi
Department of Biotechnology
Scheme of Examination
MTech in Industrial Biotechnology
First semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-521 Bioenergy 3 1 0 50 100 150 3
BT-522 Food Engineering
amp Biotechnology
3 1 0 50 100 150 3
BT-523 Enzyme
Engineering amp
technology
3 1 0 50 100 150 3
BT-571 Industrial Plant
Biotechnology
3 1 0 50 100 150 3
BT-572 Bioinstrumentation 3 1 0 50 100 150 3
BT-573 Food engineering
and Biotechnology
Lab
0 0 2 30 70 100 2
BT-524 Bioinstrumentation
Lab
0 0 2 30 70 100 2
BT-574 Self Study open
area seminar-I
0 0 1 50 - 50 1
TOTAL 360 640 1000 20
Second semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-621 Biopharmaceuticals 3 1 0 50 100 150 3
BT-6221 Bioprocess
Engineering
3 1 0 50 100 150 3
BT-6231 Biosensor 3 1 0 50 100 150 3
BT-6711 Nanobiotechnology 3 1 0 50 100 150 3
BT-6721 Environmental
Biotechnology
3 1 0 50 100 150 3
BT-673 Environmental
Biotechnology Lab
0 0 2 30 70 100 2
BT-624 Bioprocess
Engineering Lab
0 0 2 30 70 100 2
BT-674 Minor Project-I 0 0 1 50 - 50 1
TOTAL 360 640 1000 20
Third semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-721 Professional
Elective I
3 1 0 50 100 150 3
BT-722 Professional
Elective II
3 1 0 50 100 150 3
BT-723 Self Study open
area seminar-II
0 0 1 100 100 2
BT-724 Minor Project-II 300 300 6
BT-725 Major Project-I 300 300 6
TOTAL 200 800 1000 20
Fourth semester
Course
Code
Subject L T P Internal
Marks
End Sem
Marks
Total
Marks
Credit
BT-821 Major Project-II 400 600 1000 20
TOTAL 1000 20
BT- 721 ELECTIVE SUBJECTS- I
BT-7211 Bioseparation Technology
BT-7212 Industrial waste water treatment
BT-7213 Biopolymer Technology
BT-7214 Bioprocess Plant Designing
BT-7215 Transport Phenomenon
BT-7216 Biochemical Thermodynamics
BT-722 ELECTIVE SUBJECTS- II
BT-7221 Bioethics Biosafety and IPR
BT-7222 Quality Management
BT-7223 Protein Engineering
BT-722 4 Metabolic Engineering
BT-7225 Design and Development of Biological Treatment process
BT-7226 Bioinformatics
SEMESTER I
BT- 521 Bioenergy
Unit-I
Introduction
Global energy scenario Indian energy scenario types of energy sources description of Biofuels
various Biofuels Bioenergy from biomass Biofuel Production Alternative Biochemical Pathways for
Organo-heterotrophic Lithotrophic and Phototrophic Metabolism Importance of biofuel feed stocks
Cellulose starch sugar Lignocellulosic Agro and Industrial by-products
Unit-II
Production of Bio-ethanol
Process Technology for Bioethanol production using Sugar Starch and Lignocellulosic Selection of
micro-organisms and raw materials Unit Operations in Alcohol production Continuous
fermentation Distillery quality control Alcohol distillation
Unit-III
Production of Biodiesel
Chemical Thermodynamic and Reaction Kinetic Aspects of Biodiesel Production Lipids as a source
of biodiesel Methods of Biodiesel Production ndash General procedure and large scale production
Quality Control Aspects Biodiesel production from microalgae and future prospects
Unit-IV
Production of Biohydrogen
Biohydrogen production by anaerobic bacteria and photosynthetic algae Enzymes involved in
biohydrogen Production Biochemical Pathway Batch Fermentation Factors affecting biohydrogen
production Carbon sources Process and Culture Parameters Detection and Quantification of
biohydrogen
Unit-V
Microbial Fuel Cells
Introduction and biochemical basis History of microbial fuel cell development Microbes used in
microbial fuel cells Design of microbial fuel cells MFC components Two and Single MFC systems
Stacked microbial fuel cell Performances of microbial fuel cells Ideal performance Actual MFC
performance Effects of operating conditions pH buffer and electrolyte Proton exchange system
Operating conditions in the anodic chamber Operating conditions in the cathodic chamber
Applications Electricity generation Biohydrogen Wastewater treatment Biosensor MFCs in the
future
Unit-VI
Case studies
Text books
1 Caye M Drapcho NP Nhuan and T H Walker Biofuels Engineering Process Technology Mc
Graw Hill Publishers New York 2008
2 Jonathan RM Biofuels ndash Methods and Protocols (Methods in Molecular Biology Series) Humana
Press New York 2009
3 Lisbeth Olsson (Ed) Biofuels (Advances in Biochemical EngineeringBiotechnology Series
Springer-Verlag Publishers Berlin 2007
BT- 522 Food Engineering and Biotechnology
Unit- I
Food chemistry
Food chemistry-definition and importance Composition of foods and function of water
carbohydrates proteins amino acids lipids vitamins and shelf life of food Bioavailability and
stability of nutrients Nutritive value of foods Food as a source of energy Food Health and diseases
Unit ndash II
Food Microbiology
History and significance of microorganisms in foods Biotechnological improvements catabolic
repression Microbial growth pattern Biochemical changes caused by micro-organisms deterioration
of various types of food product Food poisoning and microbial toxins standards for different foods
Food borne intcericants and mycotoxius
Unit ndashIII
Fermentation products
Dairy products Production of starter cultures Cheese - principles of cheese making Cheddar
Cheese Swiss Cheese Surface ripened Cheeses Mold ripened Cheeses General principles of
manufacture of Kefir Fermented foods Soy sauce Miso Sufu Natto Idli fermented fish products
Fermented vegetables Sauer Krant pickles Olives Fermented sausages Distilled beverages
Alcohol wine brandy and beer Food additives organic acid (acetic acid lactic acid and citric acid)
amino acids (glutamic acid lysine threonine arginine and histidine) food flavourants and pigments
Unit ndashIV
Food Preservation and storage
General principles underlying spoilage and chemical changes of food caused by microorganisms
(Staphylococcal Salmonellosis Ecoli) food spoiling enzymes Botulism toxin production and
deterioration of foods Principles of food preservation by physical methods (irradiation drying heat
processing chilling and freezing high pressure and modification of atmosphere) by chemical
methods and biological methods Storage Stability Food Preservation with Low Temperatures Food
Preservation with High Temperatures Preservation of Foods by Drying Indicator and Food-borne
Pathogens
Unit V
Food process technology
Packaging and canning of foods ndash preparation for packaging thermal processing of foods
Microwave heating thermal inactivation of microorganisms thermal process evaluations freezing
and thawing of foods Food process operations Evaporation single and multi effect evaporation
dehydration psychomatric charts drying-tunnel tray spray drum freeze distillation food
processing aid through biotechnology Food sanitation Good manufacturing practices ndash Hazard
analysis Critical control points Personnel hygiene
Unit ndashVI
Food Processing and Quality assurance
Basic principles unit operations and equipment involved in the commercially important food
processing methods and unit operations materials and containers used in food packaging Objectives
importance and functions of quality control Methods of quality assessment of food materials-fruits
vegetables cereals dairy products meat and poultry Food regulations grades and standards
Concept of Codex AlmentariousHACCPUSFDAISO 9000 series etc Food laws and standards
Text Books
1 Frazier WS and Weshoff DC Food Microbiology 4th Edn McGraw Hill Book Co New
York 1998
2 Mann amp Trusswell Essentials of human nutrition 3rd edition oxford university press 2007
3 Prescott and Dunns Gerald Reed Industrial Microbiology 4th Edition AVI Publishing Company
Inc Conneticut 1983
4 BSivashankar ndash Food processing and preservation Prentice ndash Hall of India PvtLtdNew Delhi
2002
BT- 523 Enzyme Engineering and Technology
Unit-I
Introduction to enzymes
Introduction nomenclature and classification of enzyme Mechanism and catalysis concept of active
site and energetics of enzyme substrate complex formation specificity of enzyme action principles
of catalysis ndash collision theory transition state theory role of entropy in catalysis Biocatalysis in
organic liquids Enzymatic catalysis in biphasic system Ribozyme Abzyme (catalytic antibodies)
Biosynthesis and regulation of enzyme in microorganism
Unit-II
Enzyme Kinetics
Kinetics of substrate and multisubstrate reactions King-Altmanrsquos method Analysis of kinetic data
Inhibition - substrate product and inhibitors Active and legend binding sites Allosteric regulation of
enzymes Monod changeux wyman model deactivation kinetics Molecular folding and defolding of
enzymes
Unit - III
Enzyme immobilization
Methods of immobilization External and internal diffusional mass transfer limitation Effectiveness
factor and modulus electrostatic and stearic effects in immobilized enzyme systems
Unit-IV
Enzyme Reactor
Reactors for Batch continuous enzymatic processing choice of reactor type idealized enzyme
reactor systems Mass transfer in enzyme reactors Steady state analysis of mass transfer and
biochemical reaction in enzyme reactors
Unit ndashV
Purification and Characterization of enzymes from natural source
Production and purification of crude enzyme extracts from plant animal and microbial sources
methods of characterization of enzymes
Unit-VI
Application of enzymes
Application of enzymes in different industries (Pulp and Paper industry Detergent industry Textile
industry Food processing industry) Medical and analytical application of enzyme Biosensor
Text books
1 Enzymes A Practical Introduction to Structure Mechanism and Data Analysis by RA Copeland
Publisher John Wiley and Sons Inc
2 Enzymes by Palmer (2001) Horwood Publishing Series
3 Introduction to Biocatalysis using Enzymes and Microorganisms by SM Roberts NJ Turner and
A J Willetts Publisher Cambridge University Press
4 Fundamentals of Enzymology by Price and Stevens (2002) Publisher Oxford University Press
5 Enzyme Technology by Helmut Uhling (1998) Publisher John Wiley
6 Introduction to Proteins Structure by Branden and Tooze (1998) Publisher Garland Publishing
7 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady - State Enzyme
Systems by IH Segel Publisher Wiley-Interscience
BT-571 Industrial Plant Biotechnology
Unit-I
Plant genome organization
Organization and features of mitochondrial nuclear and choloroplast genome ndash Structural features of
gene families in plants
Unit-II
Plant cell cultivation
Callus cultures cell cultures and protoplast cultures Micropropagation Organogenesis and somatic
embryogenesis Cell suspension culture Ovule culture Anther culture Production of haploids
Protoplast isolation and fusion Selection systems for somatic hybridscybrids Somaclonal variation
Preservation of germplasm Formation of Secondary Metabolites in Tissue Culture Production of
pharmaceuticals by tissue culture pigments perfumes flavors insecticides flavonoids
Biotransformation using plant cell cultures Bioreactor system and models for mass cultivation of
plant cells hairy root culture Quality assurance and quality control
Unit-III
Transgenic plant and application
Transgenesis in plants Gene transfer in plants ndash Gene transfer through vectors - Biology of vectors
used - Ti and Ri plasmids binary vectors viral vectors cloning strategy and method of gene transfer
Vectorless gene transfer ndash electroporation and gene gun method DNA bar coding Application of
transgenic plants Virus resistance coat protein mediated nucleocapsid gene Nematode resistance
Abiotic stress Drought cold and salt Post-harvest losses long shelf life of fruits and flowers use of
ACC synthase polygalacturanase ACC oxidase male sterile lines bar and barnase systems
carbohydrate composition and storage ADP glucose pyrophosphatase RNAi and Reverse genetics
Unit- IV
Natural Resource Management
Different approaches of Biodiversity Conservation Biotechnological Characterization and strategies
for the conservation of different populations of endangered plants Molecular markers and genetic
diversity screening
Unit-V
Plant metabolism Metabolomics and metabolic engineering
General concepts of metabolism Introduction to databases from plant transcriptomics to
metabolomics
Unit VI
Industrial applications
Industries engaged in tissue cultureplant cell suspension culture their working and management
Pharmaseutically useful metabolites generated by suspension cultures
Text books
1 Dixon RA and Gonzales Plant Cell Culture A Practical Approach IRL Press 1995
2 Lindsey K and MGK Jones Plant Biotechnology in Agriculture Prentice Hall New Jersey
1990
3 Biotol series In vitro Cultivation of Plant cell Butterworth Heinemann Ltd 1994
4 Ranga MM Animal Biotechnology (3e) Agrobios 2007
5 Bhojwani amp Rajdhan Animal and Plant Biotechnology Elsevier 1996 )
6 Gene cloning amp DNA Analysis An introduction by T A Brown Fourth edition (2001)
7 Genetic Engineering by S Rastogi and N Pathak Publishers Oxford University Press(2009)
8 Principles of Gene Manipulation amp Genomics by Primrose amp Twyman Seven edition (2006)
BT- 572 Bioinstrumentation
Unit I
Electrochemistry Temperature pH buffers Conductivity Dissolved oxygen carbon dioxide
Unit II
Centrifugation Basic principle and application Analytical and Preparative centrifuges and ultra
centrifugation
Unit III
Electrophoretic Techniques Paper and gel electrophoresis Immuno electrophoresis isoelectric
focussing two-dimensional electrophoresis capillary electrophoresis
Unit IV
Chromatographic Methods Paper TLC gas chromatography gel filtration ion exchange
chromatography affinity chromatography and HPLC FPLC
Unit V
Spectroscopy UVvisible and NIR spectrofluorimetry Atomic absorption spectrophotometryMass
Spectrometry Infrared and Raman SpectroscopyNuclear Magnetic Resonance and Electron Spin
Resonance spectroscopy
Unit VI
Microscopy Principle parts types and functioning of Microscope Optical and Electron
Microscopy Transmission and Scanning Electron Microscopy Tunneling Electron Microscopy
Atomic Force Microscopy Fluorescence microscopy Confocal microscopy
Text books
1 Principles and Techniques of Practical Biochemistry by Keith Wilson and JohnWalker Cambridge
University Press
2 Biophysical Chemistry The conformation of Biological Macromolecules by CRCantor and PR
Schimmel Publisher WH Freeman
Reference books
1 Essentials of Biophysics by P Narayanan Publishers New Age InternationalPublishers
2 Introduction to Spectroscopy by DL Pavia GM Lampman and G S Kriz Publisher Brooks
Cole
3 Physical Chemistry of Macromolecules by C Tanford Publisher John Wileyand Sons Inc
4 Principles of Physical Biochemistry by KE Van Holde Publisher Prentice Hall
BT-524 Lab- Bioinstrumentation 1 Measurement and control of pH 2 Measurement of conductivity of a given sample
3 Measurement of conductivity and dissolved oxygen in given sample
4 Protein quantification
5 Protein separation through electrophoresis
6 Sample preparation for light microscopy and Electron Microscopy
7 Quantification of DNA RNA Lipid Fatty acids
8 Sample analysis through AAS
9 Sample preparation for Fluorescence and Confocal microscopy
10 Isolation of DNA and analysis by gel electrophoresis
BT-573 Lab- Food Engineering and Biotechnology
1 Isolation of industrially important microbes
2 Production of fermented product
3 Comparative studies of ethanol production using different substrates
4 Production of wine
5 Production of citric acid
6 Detection of adulterants in food
7 Mushroom cultivation
8 Bread making
9 Colourant production
10 Studies of different methods of food preservation
11 Estimation of carbohydrates and proteins
BT-574 Self Study Open Area Seminar-I
SEMESTER II BT- 621 Biopharmaceuticals
Unit-I
Drug metabolism Oxidation reduction hydrolysis conjugation Need for developing new drugs
Procedure followed in drug design Molecular modification of lead compounds Prodrug and soft
drugs Physico-chemical parameters in drug design QSAR Active site determination of enzymes
Design of enzyme inhibitors
Unit-II
Pharmacokinetics and Drug discovery
Biotransformation of drugs Preclinical Pharmacokinetics Compartment modelingone compartment
open model two compartment open model multi compartment model non linear kinetics
bioavailability and bioequivalence excretion of drugs pharmacokinetics ndash effects of food and
fasting Substances derived from bacteria plants insects and animals Sources of active principles
Assay systems and models (eg Knock-out Mice) Protein molecular modeling by computer
Docking studies Structure based drug designing using software
Unit-III
Pharmaceutical dosage forms
Dosage Forms and Basic Preparations Excipients for Pharmaceutical Dosage Forms Compressed
tablets wet granulation dry granulation or slugging direct compression tablet formulation coating
capsules sustained action dosage form parental oral liquids ointments recombinant blood products
and therapeutic enzymes hormones of therapeutic interest Pharmaceutical products Analysis and
Control laxatives ndash analgesics ndash non steroidal contraceptives ndash external antiseptics ndash antacids and
other antibiotics ndash biological ndash hormones ndash vitamins - preservation analytical methods and test for
various drugs and pharmaceuticals packaging techniques ndash quality control
Unit-IV
Pharmaceutical products and products of DNA technology
Microbial products - Antibiotics (penicillin streptomycin tetracycline) vitamins probiotics Plant
secondary metabolites - control mechanism and manipulation of pheny-propanoid pathway and
shikimate pathway Tissue culture production of alkaloids flavanoids steroids terpenoids animal
vaccines Pharmaceutical products of DNA technology Therapeutic proteins ndash Insulin human
growth hormone clotting factors interferons interleukins tissue plasminogen activators
erythropoietin DNAseI alginate lyase muteins Production advantages limitations and applications
of monoclonal antibody Oligonucleotides and Gene therapy ras-Antisense therapy gene delivery
system Vector usage strategies for gene therapy Clinical trials
Unit-V
Drug safety evaluation
Strategy and Phasing for Drug Safety Evaluation in the Discovery and Development of
Pharmaceuticals Regulation of Human Pharmaceutical Safety Acute Toxicity Testing in Drug
Safety Evaluation Special Concerns for the Preclinical Evaluation of Biotechnology Products
Immunotoxicology in Pharmaceutical Development The Application of In Vitro Techniques in Drug
Safety Assessment Pharmaceutical Quality Assurance
Unit-VI
Patenting process in drug manufacturing process
Patenting- Patent types The patent application Patenting in biotechnology Preclinical trials Clinical
trials The role and remit of regulatory authorities-The Food and Drug Administration The
investigational new drug application The new drug application European regulations Guides to
good manufacturing practice Formulation and Delivery Issues of Therapeutic Proteins
Biotechnology-Derived Drug Products Formulation Development Stability Testing Filling and
Packaging
Text books
1 Heinrich Klefenz Industrial pharmaceutical biotechnology John Wiley sons 2002
2 Susanna Wu-Pong Yongyut Rojanasakul and Joseph Robinson Biopharmaceutical drug and
design and development Humana Press 2007
3 Gary Walsh Biopharmaceuticals Biochemistry and Biotechnology (2e) John Wiley amp Sons
2003
4 Herbert A Kirst Wu-Kuang Yeh Milton J Enzyme Technologies for pharmaceutical and
biotechnological applications WILEY-VCH Verlag 2003
BT- 6221 Bioprocess Engineering
Unit I
Media design and Sterilization kinetics
Criteria for good medium medium requirements for fermentation processes carbon nitrogen
minerals vitamins and other complex nutrients oxygen requirements medium formulation of
optimal growth and product formation examples of simple and complex media medium
optimization methods ndash Plackett and Burman and Response surface method Thermal death kinetics
of microorganisms batch and continuous heat sterilization of liquid media design of sterilization
equipment-batch and continuous ilter sterilization of liquid media air sterilization
Unit II
Metabolic stoichiometry and energetics
Stoichiometry of cell growth and product formation elemental balances degrees of reduction of
substrate and biomass available electron balances yield coefficients of biomass and product
formation maintenance coefficients energetic analysis of microbial growth and product formation
oxygen consumption ndash steps involved in the transfer of oxygen to broth and heat evolution in aerobic
cultures
Unit III
Growth and Production kinetics
Kinetic models for microbial growth Monod model growth of filamentous organisms product
formation kinetics - leudeking-piret models substrate and product inhibition on cell growth and
product formation Production kinetics Design for single and multiple reaction size comparisons of
single reactor for single reactions multiple reactor systems for single reaction reactions in parallel
in series and seriesparallel reactions of first order Heterogeneous reactions kinetics and mechanism
of heterogeneous non catalytic and catalytic reactions Non ideal flow - residence time distribution
studies CE F and I curves RTD in ideal reactors Models for Non ideal flow ndash zero ndash parameter
model One parameter model and two parameter model
Unit IV
Types and design of bioreactor
Construction material Basic components ndash Agitator aerator valves and steam traps seals stirrer
glands Stirred tank batch bioreactor stirred batch bio reactor for enzymes cell cultures Continuous
Stirred Tank Bioreactor Continuous operation of mixed reactor enzyme reactions in a mixed
reactor substrate inhibition kinetics and product inhibition kinetics chemostat with cell cultures ndash
steady state cell and substrate concentrations and productivity as a function of dilution rate CSTR
with immobilized enzymes operation of CSTR in a constant feed rate policy-simulation for
conversions with and without diffusion limitations chemostat in series Graphical design Plug Flow
and Packed Bed Bioreactor Performance equation with Michelin-Menten kinetics substrate
inhibition and product inhibition plug flow reactor for immobilized enzymes operation of plug flow
reactor in constant feed rate policy simulation for conversion with and without diffusion limitations
Fedndashbatch reactor Applications of fed reactor Fed batch operation of mixed reactor material
balance on cell and substrate Recycle system Chemostat with recycle Biological waste water
treatment Feed forward control of the activated sludge process The Transient Behavior of
Bioreactors Stability analysis Stability of the chemostat Stability of chemostat with substrate
inhibition Operating diagram Transient responses of the chemostat control of the chemostat
Turbidostat operation Nutristat operation
Unit V
Instrumentation and Control
Biochemical process variables and their measurements Control principles and their application in
bioreactors Theory of electrode processes and their applications Measurement and control of pH
temperature dissolved oxygen aeration and agitation redox potential foam etc On-line analysis of
process parameters Introduction to biosensors Transduction principles used in biosensors
Characteristics of biosensors Biosensors based on amperometric potentiometric thermistor FET
fiber optics and bioluminescence Microbial biosensors Fundamentals of digital process control Use
of computer in control and optimization of microbiological processes
Unit VI
Downstream processing
Removal of microbial cells and solid matter foam separation precipitation filtration centrifugation
cell disruptions liquid-liquid extraction chromatography membrane process drying and
crystallization Quality analysis and product formulation - Product appearance product stabilization
shelf life analysis usage specific formulations quality analysis and control
Text books
1 Biochemical Engineering Fundamentals by JE Baily and DF Ollis Publisher McGraw Hill
(1986)
2 Biochemical Engineering by SAiba AE Humphry and NF Millis Publisher University of
Tokyo press(1973)
3 Bioreaction engineering principles by J Nielson and J Villadsen Publisher Plenum Press (1994)
4 Chemical Engineering Design Fourth edition by JM Coulson and JF Richardson Publisher
Butterworth Heinemann(2005)
5 Bioprocess Engineering- Kinetics Mass transport reactors and gene expression by WR Veith
Publisher John Wiley and Sons Inc(1994)
6Bioprocess Engineering Basic Concepts by ML Shuler and F Kargi Publisher Prentice Hall
(1987)
7Bioprocess engineering principles by P Doran Publisher- Academic press (1995)
BT-6231 Biosensor Unit-I
Introduction
A historical perspective Definition and Expanding Needs of Biosensors Advantages and limitations
Biosensor Economics various components of biosensors
Unit-II
Types of Biosensors
Biocatalysts based biosensors bio affinity based biosensors amp microorganisms based
biosensors biologically active material and analyte Types of membranes used in
biosensor constructions
Unit-III
Transducers in Biosensors
Various types of transducers principles and applications Bio- chemi- and lectrochemiluminescence
for fiber-optic biosensors Fluorescence-based fiber-optic biosensors
Unit-IV
Electrical Signal Detection in Biological Systems
Silicon glass and metal electrodes amplifier design Bioelectronic device production
microelectronic fabrication methods as adapted to bioelectronics hard and soft lithography bio-
compatibility of materials Existing types of Biosensors Miniaturisation and micro-systems
including sensing using optical techniques field effect transistors ion-selective and enzymatic
sensitive electrodes as well as impedance monitoring
Unit-V
Kinetic modeling for biosensors
The purpose and practice of modeling The flux equations The flux diagram for the membrane
enzyme electrode Deriving a complete kinetic model Kinetic modeling in other types of
biosensors- Potentiometric enzyme electrodes Optical and photometric biosensors Immunosensors
Unit-VI
Application and Uses of Biosensors
Biosensors in medicine and health care (For glucose monitoring and for DNA analysis Analysis of
the neural cell impulse signal and neural signal processing) biosensors for agriculture and food Low
cost- biosensor for industrial processes for online monitoring biosensors for environmental
monitoring
Text books
1 Rajmohan Joshi Biosensors (1e) Gyan Books 2006
2 Cooper JM and Anthony EG Biosensors (2e) Oxford University Press 2004
3 Turner APF KarubeI and WilsonGS Biosensors Fundamentals and applications Oxford Univ
Press 1990
4 SadanaA Biosensors Kinetics of Binding and Dissociation Using Fractals (1e) Elsevier BV
1995
5 Ashok M and Kim Rogers Enzyme amp Microbial Biosensors Techniques and Protocols (Methods
in Biotechnology) (1e) Humana Press 1998
6 Ashok M and Kim Rogers Affinity Biosensors Techniques and Protocols (Methods in
Biotechnology) (1e) Humana Press 1998
7 Damia Barcelo Biosensors for the Environmental Monitoring of Aquatic Systems Bioanalytical
and Chemical Methods for Endocrine Disruptors (1e) Springer 2009
BT-6711 Nanobiotechnology
Unit-I
Introduction
Nano - definition The fundamental Science behind nanotechnology- electrons atomsand ions
molecules metals biosystems Synthesis and Characterizations of Nanoscale Materials Strategies for
Nano architecture (top down and bottom up approaches) Fabrication Technologies and
Characterizations Self-assembly Systems Basic aspects of Nanofluidics surfactants polymers
emulsions and colloids Nanoscale Artificial Platforms Lipids in Self-assembly Structures
Nanoparticle synthesis in plants bacteria and yeast and its applications
Unit-II
Nano-structured materials
Fullerenes - Properties and CharacteristicsCarbon Nanotubes - Characteristics and Applications
Quantum Dots and WiresGold Nanoparticles Nanopores carbon nanotubes Applications of
NanoMolecules in Biosystems
Unit-III
Structural and functional principles of nanobiotechnology
Structural principle Factors governing biomolecular structure and stability Protein folding Self
assembly Self-organization Molecular recognition and Flexibility of biomaterials Functional
principles of Bionanotechnology Information driven nanoassembly Energetics Role of enzymes in
chemical transformation allosteric motion and covalent modification in protein activity regulation
Structure and functional properties of Biomaterials Bimolecular motors ATP Synthetase and
flagellar motors Traffic across membranes Potassium channels ABC Transporters and
Bactreriorhodapsin Bimolecular sensing Self replication Machine-Phase Bionanotechnology
Unit-IV
Bionanomachines and their Basic
Negligible gravity and inertia atomic granularity thermal motion water environment and their
importance in bionanomachines The role of proteins amino acids nucleic acids lipids and
polysaccharides in modern biomaterials Overview of natural Bionanomachines Thymidylate
Sythetase ATP synthetase Actin and myosin Opsin Antibodies and Collagen
Unit-V
Biophotonics and Bioimaging
Overview of imaging biological systems from the cellular level through to wholebody medical
imaging Introduction to biophysics basic physical concepts in imaging Major techniques using
ionizing and non-ionizing radiation fluorescence and multi-photon microscopy spectroscopy OCT
MRI X-ray CT PET and SPECT imaging
Unit-VI
Application of Nanobiotechnology
Nano-biotechnology in drug Delivery Nanoscale Devices for Drug Discovery Micelles for Drug
Delivery Protein targeting Small Molecule-Protein Interactions Micro-array and Genome Chips
Nanotechnology and the Cell Cell Motility Nano Motors and Cellular Navigation hemotaxis -
Transmembrane Signalling and Related Protein Nanotechnology for Cancer Diagnostics and
Treatment Nanotechnology for Cancer Research and Therapy siRNA Tumor-targeted Drug
Delivery Systems Nanotechnology for Imaging and Detection
Text Books
1 NANO by TPradeep 2006Tata Mc Graw Publishers India
2 Nanobiotechnology Concepts Applications and Perspectives Christof MNiemeyer Chad
AMirkin (eds) Wiley-VCH Weinheim (2004)
3 Kamali Kannangara Geoff Smith Michelle Simmons Burkhard Raguse
4 Overseas Press (2005)
5 David S Goodsell Bionanotechnology John Wiley amp Sons 2004
6 Greco Ralph S Nanoscale Technology in Biological Systems CRC Press 2005
BT-6721 Environmental Biotechnology
Unit-I
Basic concepts of ecology Interaction between environment and biota Concept of habitat and
ecological niches Limiting factor Energy flow food chain food web and trophic level NPC and S
cycles in nature Ecosystem dynamics and management Environmental impact assessment
Principles of conservation Conservation strategies sustainable development Global environmental
problems ozone depletion UV-B radiation green house effect and acid rain their impact in
biotechnological approaches for management
Unit-II
Environmental pollution
Types of pollution and pollution analysis ndash noise air and gaseous pollution Noise pollution Source
measurement impact on ecosystem and control Air pollution Types source method of sampling
measurement impact on ecosystem and control Control of noise and air pollution by
biotechnological methods Gaseous pollutants and odours General sources methods of control
fundamentals of adsorption mechanism of adsorption equilibrium isotherms break through curve
adsorption equipment regeneration of adsorbent application of adsorption for control of gaseous
and odour emission
Unit-III
Water pollution Impurities in water water pollution by industrial waste examination of water
collection of water samples water analysis ndash physical chemical and biological Standards of water
quality Water treatment processes Primary treatment screening skimming with coagulants
flocculation filteration aeration and disinfection Secondary treatment Aerobic processes ndash
activated sludge oxidation ditches recirculating system trickling filter towers rotating discs
rotating drums oxidation ponds Anaerobic digestion anaerobic filters Up flow anaerobic sludge
blanket reactors Tertiary treatment Activated carbon treatment reverse osmosis and electro dialysis
Unit-IV
Bioremediation
In situ and ex situ bioremediation technologies for various pollutants and sites bioremediation of oil
spills and heavy metal pollution use of microbes in bioremediation hydroponic system pollution
control boards and pollution control acts
Unit-V
Solid waste management sewage sludge treatment and utilization refuse disposal excreta disposal
in unsewered area composting and vermiculture biodegradation of noncellulosic wastes for
environmental conservation and fuel bioconversion of cellulosic wastes into protein and fuel
bioremediation of contaminated soils and waste lands radioactive product waste disposal
Unit-VI
Effluent treatment Sources of pollution impact on ecosystem and treatment of following industrial
effluents starch paper and pulp tannery dairy distillery oil refineries and pharmaceutical
Microbes in mining ore leaching oil recovery biopolymers biosurfactants
Text Books
1 Bruce E Rittmann and perry L Mccarty ldquoEnvironmental Biotechnology Principle and
Applicationsrdquo McGraw Hill publishing company Ltd2001
2 Mecalf and Eddy Inc ldquoWastewater Engineering Treatment Disposal Reuserdquo McGraHill
publishing company Ltd1991
3 Des W Connell ldquoBasic concepts of Environmental chemistryrdquo Lewis publishers2005
4 Michal J PelczarECS ChanNoel RKriegTata McGraw Hill publishing company Ltd1993
5 Alan Scragg Environmental BiotechnologyOxford University press2005
6 Prescott Harley Klein Microbiology WCB publishers1996
7 Richard T Wright and Bernard J Nebel ldquoEnvironmental Science towards a Sustainable Futurerdquo
Prentice Hall of India 2004
BT-624-Bioprocess Engineering Lab
1 To determine the concentration of protein content by Lowry method
2 To determine the concentration of sugar by 3 5 dinitrosalicylic acid method
3 To determine the optimum pH for given enzyme sample
4 To determine the optimum temperature for given enzyme sample
5 To study the immobilization of invertase enzyme
6 Measurement of citric acid production by Aspergillus niger with TLC
7 Determination of thermal death point (TDP) of the given microorganism
8 Production of ethanol from yeast fermentation of sugars
9 To prepare the growth curve of micro-organism cultured in a shake flask
10 To study the kinetics of lipase enzyme
BT-673- Environmental Biotechnology Lab 1 Environmental Impact Assessment Measurement of Air and Noise Pollution
2 Analysis of water temperature and pH
3 Measurement of Conductivity and TDS in water
4 Measurement of Dissolved Oxygen
5 Measurement of Carbondi Oxide and Hardness of water
6 Measurement and analysis of Ammonia and Ammonium in water
7 Measurement of Nitrite Nitrate and Total Nitrogen in water
8 Biochemical Oxygen Demand and Chemical Oxygen Demand measurements and analysis
9 Analysis of any one industrial effluent
10 Production of methane from sewage sludge
11 Vermicomposting
BT-674 Minor Project- I
SEMESTER III
BT-721 1 Elective ndash Bioseparation Technology Unit- I
Role of Downstream Processing in Biotechnology
Role and importance of downstream processing in biotechnological processes Problems and
requirements of bioproduct purification Economics and downstream processing in Biotechnology
Cost cutting strategies characterstics of biological mixtures process design criteria for various
classes of bioproducts (high volume-low value products and low volume- high value products)
physicochemical basis of bioseparation processes
Unit- II
Primary Separation and Recovery Processes
Cell disruption methods for intracellular products removal of insolubles biomass (and particulate
debris) separation techniques flocculation and sedimentation centrifugation and filtration methods
Precipitation methodsPrecipitation with salts organic solvents amp polymers
Unit- III
Extraction
Batch extractions staged extractions-cross current co current counter current extractions
Differential extractions fractional extractions with a stationary phase fractional extractions with two
moving phases Aqueous two-phase extraction reverse micelle extraction supercritical fluid
extraction in-situ product removalintegrated bioprocessing
Unit- IV
Membrane-based separations (micro- and ultra-filtration)
Theory design amp configuration of membrane separation equipment applications
reverse osmosis dialysis electro dialysis Isoelectric focusing
Unit- V
Adsorption
Adsorption isotherms industrial adsorbents adsorption equipments for batch and continuous
operations (co current and counter current) adsorption in fixed beds
Unit- VI
Chromatography
Principles of chromatographic separation ndash gel filtration reversed phase hydrophobic interaction
ion-exchange expanded bed adsorption bio affinity and IMAC supercritical fluid chromatography
Text books
1 Belter PA Cussler E and Wei Shan Hu Bioseparation ndash Downstream Processing for
Biotechnology Wiley Interscience 1988
2 Asenjo and Juan A Asenjo Separation Processes in Biotechnology CRC Press 1990
3 Wankat PC Rate Controlled Separation Kluwer Publishers 1990
4 Wang DIC Cooney CL Demain AL DunnilP Humphery AE and Lilly MD Fermentation
and Enzyme Technology John Wiley and Sons 1979
BT-721 2 Elective - Industrial Waste water treatment
UNIT I
Waste disposal management Methods of waste disposal industrial waste (solid liquid and gaseous
emission) effect of industrial wastes on streams and sewerage systems Treatment system of waste
disposal eg Incenerator differences in waste quality and quantity physico-chemical and biological
treatments of waste and their evaluation in respect of treatment
UNIT II
Characteristic features of wastes (solid liquid and gaseous emission) manufacturing processes and
toxic byproducts generated from iron ore alumina heavy metals units paper and pulp industries
pesticides industry thermal power station distillery textile and crude oil industry
UNIT III
Small and large scale industries for waste reduction and remediation various methods for waste
alteration volume and strength minimization recycling plants material restoration and conservation
Methods for neutralisation equalization precipitation and solidification for waste handling
Economic sustainability and government support for joint treatment of raw effluent municipal
sewage and debris
UNIT IV
Unit operations and their design for treatment and management of wastes (solid liquid and gaseous)
UNIT V
Landfill design and operation including site selection engineered sites liners and covers leachate
control and treatment gas recovery and control including utilization of recovered gas (energy) and
landfill monitoring and reclamation
UNIT VI
Case studies
Text Books
1 S P Mahajan ldquoPollution Control in Process Industriesrdquo Tata Mc Graw Hill Publications
2 W Wesley Eckenfelder Jrrdquo Industrial Water Pollution Controlrdquo Mc Graw Hill Publications
3 Ronald W Crites Sherwood C Reed and Robert Bastion ldquoLand Treatment Systems for Municipal
amp Industrial Wastesrdquo Mc Graw Hill Publications
4 Neal K Ostler ldquoIndustrial Waste Stream Generationrdquo Prentice Hall
5 Rao and Dutta ldquoIndustrial waste treatmentrdquo Oxford and IBH Publishing Co Pvt Ltd New Delhi
6 Dr A D Patwardhan ldquoindustrial Waste Water Treatmentrdquo Prentice Hall of India
BT-721 3 Elective-Biopolymer Technology Unit-I
Introduction
Biopolymers ndash The current scenario different biopolymers ndash produced from various renewable
resources characteristics merits and demerits over conventional polymers
Unit-II
Biopolymer Technology and Applications
Biopolymers and Artificial Biopolymers in Biomedical Applications an Overview Novel Synthesis
of Biopolymers and Their Medical Applications Composite Films Based on Poly (Vinylalcohol) and
Lignocellulosic Fibres Preparation and Characterizations Composite Materials Based on Gelatin
and Fillers from Renewable Resources Thermal and Mechanical Properties Properties of PHAs and
Their Correlation to Fermentation Conditions
Unit-III
Biosynthesis and Modifications
Synthesis and modification of different Biopolymers like xanthum gum
Unit-IV
Biosurfactants
Source characteristics and properties of Biosurfactants Production of Biosurfactants via the
fermentation and biotransformation routes Production of Biosurfactants with immobilized cells
Integrated bioprocess for continuous production of Biosurfactants including downstream processing
Applications of Biosurfactants-Food Industry Environmental Control
Unit-V
Bioplastic
Different types of bioplastics Starch-based plastic Cellulose-based plastic Aliphatic polyesters
Poly-3-hydroxybutyrate (PHB) Polylactic acid (PLA) Polyamide Bio-derived polyethylene
Advantages of bioplastic over petroleum-based polymer Mechanism of synthesis of Poly (-
hydroxybutyric acid) (PHB)
Unit-VI
Material Testing and Analytical Methods
An Overview of Available Testing Methods Comparison of Test Systems for the Examination of the
Fermentability of Biodegradable Materials Structure- Biodegradability Relationship of biopolymers
Text Books
1 Emo Chiellini Emo Chiellini and Helena Gil Biorelated Polymers Sustainable Polymer Science
and Technology Springer 2001
2 Johnson RM LY Mwaikambo and N Tucker Biopolymers Rapra Technology 2003
3 Naim Kosaric (Ed) Biosurfactants Marcell Dekker Inc 1993
BT-721 4 Elective ndash Bioprocess Plant Designing Unit-I
Process development
Introduction to Design ndash nature of design ndash Technical feasibility survey Mass and energy balance
process development ndash data acquisition ndash design data information of project - Organization of project
ndash Project documentation ndash codes and standards
Unit-II
Design Development
Equipment selection and specifications-materials of construction ndash flow sheeting - piping and
instrumentation ndash process safety and loss prevention
Unit-III
General site consideration
Introduction ndash plant location and site selection ndash site layout- plant layout utilities ndash environmental
considerationsndash waste management ndash visual impact ndash government regulations and other legal
restrictions community factors and other factors affecting investment and production costs ndash human
resources
Unit ndashIV
Selection and specification
Selection and specification of equipment for handling fluids and solids Selection specification
design of heat and mass transfer equipment used in bioprocess industries Design of facilities for
cleaning of process equipment used in biochemical industries Utilities for biotechnology
Unit-V
Design of fermenters
Design of fermentation Design considerations for maintaining sterility of processing equipment
Unit-VI
Process economics
Production plants Bioprocess validation Safety considerations
Text books
1 Applied Process Design for Chemical and Petrochemical Plants by EE Ludwig Publisher
Butterworth-Heinemann
2 Chemical Engineering by RK Sinnott JM Coulson and JF Richardsons Publisher
Butterworth-Heinemann Vol-6 Butterworth Heinemann III editionndash 2002
3 Peters and Timmerhaus Plant Design and Economics for Chemical Engineers Mcgraw Hill
4thEdition 1989
4 Rudd and Watson Strategy of Process Engineering Wiley 1987
BT-721 5 Elective- Transport Phenomenon Unit -I
Diffusion
Molecular and turbulent diffusion Diffusion coefficient Flickrsquos Law of diffusion Dependence of
diffusion coefficient on temperature pressure and composition Diffusion in multi-component gas
mixtures Diffusion in solids Molecular Knudsen ampsurface diffusion Inter- phase mass transfer
Mass transfer coefficients Diffusion between phases Equilibrium solubility of gases in liquids
Mass Transfer theories Mass transfer in fluidized beds flow past solids and boundary layers
Simultaneous heat and mass transfer Mixing in a Bioreactor -Flow regimes with and without baffles
various types of impellers and mixing equipment Power Requirements for Mixing Ungassed
Newtonian Fluids Gassed Fluids Improving Mixing in Fermenters Effect of Rheological Properties
on Mixing Role of Shear in Stirred Fermenters
Unit-II
Drying and Crystallization
Solid-gas equilibria Different modes of drying operation Types of batch and continuous dryer
Definitions of moisture contents Rate of batch drying Time of drying Mechanism of batch drying
Continuous drying Equilibrium yield of crystallization Heat and mass transfer rates in
crystallization Theories of crystallization Factors governing nucleation and crystal growth rates
controlled growth of crystal Classification of crystallizers
Unit ndashIII
Absorption and Adsorption
Gas-Liquid equilibriaHenryrsquos Law Selection of solvents Absorption in tray column Graphical and
analytical methods Absorption in packed column Design equation for packed column HTU NTU
and HTEP concepts Equipments Description of adsorption process and their application Types of
adsorption Nature of adsorbents Adsorption equilibrium and adsorption hysterises Stage wise and
continuous contact adsorption operation operations Determination of number of stages Equipments
Unit-IV
Momentum transfer
Review of basic concepts ndash Conservation of Mass Conservation of Energy Momentum Balance ndash
Momentum Balance in a Circular Pipe Flow Velocity Profile Fermentation Broth Rheology ndash
Viscosity Rheological Properties of Fermentation Broths Factors affecting broth viscosity
Unit V
Conduction and Convection
Introduction Conduction Basic concepts of conduction in solids liquids and gases One and two
dimensional heat conduction Critical and optimum insulation thickness Introduction to unsteady
state heat transfer Principles of convection Equations of forced and free convection
Unit ndashVI
Radiation
Basic laws of heat transfer by radiation black body and gray body concepts solar radiations
combined heat transfer coefficients by convection and radiation Introduction of Heat Transfer
Equipments Heat Exchangers Evaporators Condenser
Text Books
1 Holman JP ldquoHeat Transferrdquo 9 th ed McGraw Hill (1989)
2 Treybal R ldquoMass Transfer Operationsrdquo 3rd ed New York McGraw-Hill (1980)
3 McCabe Smith Unit Operations in Chemical Engineering McGraw Hill
4 Foust A S etal ldquoPrinciples of Unit Operationsrdquo John Wiley (1980)
5 R B Bird et al Transport Phenomena 2nd Edition Wiley(2006)
BT-721 6 Elective ndash Biochemical thermodynamics Unit-I
Fundamental concepts of Thermodynamics
System and Surroundings First law of thermodynamics -Internal energy enthalpy Heat capacity
applied examples from biochemistry Second law ndash Entropy and universe Concept of heat engines
protein stability and calorimetric measurements Fundamentals of Differential scanning calorimeter
and Isothermal calorimeter in biological property measurements Third law of thermodynamics
Maxwell equations Gibbs-Duhem Equation and the Phase Rule Legendre Transforms
Unit-II
Non-equilibrium Thermodynamics
Reversible work exact differentials and function of state first and second law The electrochemical
potential External forces and steady state Fickrsquos Law chemical reactions in the steady state internal
entropy production cells as non-equilibrium stationary states Diffusion and membrane transport
Biological Systems as Open Non-equilibrium Systems Failure of classical thermodynamics in
describing biological processes Standard free energy changes and equilibrium constants direction
and rate
Unit-III
Bioenergetics
Energetics of metabolic pathways ndash energy coupling (ATP amp NADH) stoichiometry ndashenergetic
analysis of cell growth and product formation ndash elemental balances Degree ofreduction concepts
available- electron balances yield coefficients oxygen consumptionand heat evolution in aerobic
cultures thermodynamic efficiency of growth Thermodynamics of Biological Systems
Thermodynamic analysis of oxidative photophosphorylation stability of non-equilibrium stationary
states ordering in time and space far from equilibrium glycolytic oscillations Biological clocks
routes to chaos
Unit-IV
Chemical Potential
Visualization of the potential Steady velocity and steady flow Fickrsquos law and diffusion Local
Equilibria and Steady State Energy vs Power Transducers in biological states Constitutive
equations Dynamic efficiency and Onsager (nonequilibrium thermodynamics) Prigoginersquos principle
Spontaneous coupling and entropy production
Unit-V
Gibbs free energy and its Applications
Gibbs free energy and equilibrium Chemical potential ionic solutions Equilibrium constant
standard state in biochemistry Acid and bases chemical coupling and redox reactions Gibbs free
energy in photosynthesis glycolysis citric acid cycle Oxidative phosphorylation and ATP
hydrolysis substrate cycling Membrane transport Enzyme substrate interaction Haemoglobin
Protien solubility stability and dynamics
Unit-VI
Reaction Kinetics
Rate of a reaction rate constant and order of the reaction effect of temperature collision and
transition state theory Electron transfer kinetics Enzyme kinetics and inhibition Reaction
mechanism of lysozyme protein folding and pathological misfolding polymerisation muscle
contraction and the molecular motors
Text Books
1 Smith JM Van Ness HC Abbot MM Chemical Engineering Thermodynamics 6th Edition
McGraw-Hill 2001
2 Narayanan KV A Text Book Of Chemical Engineering Thermodynamics Prentice Hall India
2001
3 Sandler SI Chemical And Engineering Thermodynamics John Wiley1989
4 Bailey amp Ollis Biochemical Engineering Fundamentals II edition Megraw Hil ndash 1986
5 Donald T Haynie Biological Thermodynamics Cambridge press 2008
6 Robert A Alberty Thermodynamics of Biochemical Reactions John willy publications 2003
7 Bioenergetics by AL Lehninger Publisher WA Benjamin Inc
8 Biological Thermodynamics by DT Haynie Publisher Cambridge University Press
9 Biophysical Chemistry by CR Cantor and PR Schimmel Publisher
10 FreemanThermodynamics and Kinetics for the Biological Sciences by GG Hammes Publisher
John Wiley and Sons Inc
BT-7221 Elective - Bioethics Biosafety and IPR Unit I
Introduction to ethics and bioethics
Personal ethics profession and professionalism -Moral Reasoning -Ethical theories - person as an
experimenter -Moral leadership (integrity and ingenuinity) ndash framework for ethical decision making
Biotechnology and ethics Biotechnology in agriculture and environment benefits and risks ndash
benefits and risks of genetic engineering ndash ethical aspects of genetic testing ndash ethical aspects relating
to use of genetic information ndash genetic engineering and biowarfare
Unit-II
Ethical implications of cloning
Reproductive cloning therapeutic cloning Ethical legal and socio-economic aspects of gene
therapy germ line somatic embryonic and adult stem cell research- GM crops and GMO‟s ndash
biotechnology and biopiracy ndash ELSI of human genome project
Unit-III
Introduction to biosafety
Biosafety issues in biotechnology ndash risk assessment and risk management ndash safety protocols risk
groups ndash biosafety levels ndash biosafety guidelines and regulations (National and International) ndash
operation of biosafety guidelines and regulations ndash types of biosafety containment International
guidelines with regard to rDNA technology transgenic science GM crops etc Experimental
protocol approvals levels of containment Guidelines for research in transgenic plants Good
manufacturing practice and Good lab practice (GMO and GLP)
Unit-IV
Introduction to intellectual property and intellectual property rights
Types patents copy rights trade marks design rights geographical indications ndash importance of IPR
ndash patentable and non patentables ndash patenting life ndash legal protection of biotechnological inventions ndash
world intellectual property rights organization (WIPO) Plant breederrsquos rights Legal implications
Biodiversity and farmers rights Examples of patents in biotechnology Special application of patent
laws in biotechnology Licensing and cross licensing Flavr SavrTm- Tomato as model case and case
studies
Unit-V
Public acceptance issues for biotechnology
Environmental aspects of biotech application Use of genetically modified organisms and their
release in environment Case studies or experiences from developing and developed countries
Biotechnology and hunger Challenges for the Indian Biotechnological research and industries
Unit-VI
Socioeconomic impacts of biotechnology
The legal and socioeconomic impacts of biotechnology public education of the processes of
biotechnology involved in generating new forms of life for informed decision making
Text Books
1 Ethics in engineering Martin MW and SchinzingerR III Edition Tata McGraw- Hill New
Delhi 2003
2 Biotechnologies and Development UNESCO Publications 1988
3 A Biotechnologies in developing countries present and future UNESCO Publishers 1993
4 Singh K Intellectual property rights on Biotechnology BCIL New Delhi
BT-722 4 Elective ndash Metabolic Engineering Unit ndash I
Cellular metabolism
An overview of cellular metabolism-transport processes- Fueling reactions -glycolysis-fermentative
pathways-TCA cycle and oxidative phosphorylation-anaplerotic pathways -catabolism of fats
organic acids and amino acids -biosynthetic reactions of amino acids ndash nucleic acids fatty acids and
other building blocks -polymerization - growth energetics
Unit ndash II
Comprehensive models for cellular reactions
Stoichiometry of cellular reactions -reaction rates-dynamic mass balances-Yield coefficients and
linear rate equation Material Balance and data consistency ndashblack box model elemental balance -
heat balance -analysis of over determined systems - identification of gross measurement errors
Unit ndash III
Regulation of metabolic pathways
Overview of enzyme kinetics ndash simple reversible inhibition systems ndash irreversible inhibition ndash
allosteric enzymes cooperativity ndash regulation of enzyme concentration ndash transcription initiation ndash
translation regulation at whole cell level ndash regulation of metabolic networks enhancements of
product yield and productivity for ethanol and amino acids pathways metabolic pathway
manipulations to extend substrate range product spectrum and novel products improvement of
cellular properties
Unit ndash IV
Metabolic flux analysis
Theory ndash overdetermined systems ndash underdetermined systems ndash sensitivity analysis ndash methods for the
experimental determination of metabolic fluxes by isotope labeling direct flux determination from
fractional enrichment ndash applications involving complete enumeration of metabolite isotopomers ndash
carbon metabolite balances Applications of metabolic flux analysis ndash amino acid production by
Glutamic acid Bacteria
Unit ndash V
Metabolic control analysis
Fundamentals of Metabolic control analysis -determination of flux control coefficients ndash MCA of
Linear pathways ndash branched pathways ndash theory of large deviation
Unit-VI
Applications of metabolic engineering
Text Books
1 Gregory N Stepanopoulos Aristos A Aristidou Jens Nielsen Metabolic Engineeing
2 Principles and methodologies Academic Press 1998
3 Wang DIC Cooney CL Demain AL DunnilP Humphery AE Lilly MD
4 ldquoFermentation And Enzyme Technologyrdquo John Wiley And Sons 1980
5 Zubay G ldquoBiochemistryrdquo Macmillan Publishers 1989
BT-722 3 Elective ndash Protein Engineering Unit-I
Bonds and Energies in protein
Covalent Ionic Hydrogen Coordinate hydrophobic and Vander walls interactions in protein
structure Interaction with electromagnetic radiation (radio micro infrared visible ultraviolet X-
ray) and elucidation of protein structure
Unit-II
Amino acids and their characteristics
Amino acids ndash structure with three and single letter codes- molecular properties (size solubility
charge pKa) Chemical reactivity in relation to post-translational modification (involving amino
carboxyl hydroxyl thiol imidazole groups) and peptide synthesis
Unit - III
Protein architecture
Primary structure peptide mapping peptide sequencing - automated Edman method amp massspec
High-throughput protein sequencing setup Secondary structure Alpha beta and loop structures and
methods to determine Super-secondary structure Aphaturn- alpha beta-turn-beta (hairpin) beta-
sheets alpha-beta-alpha topology diagrams up and down amp TIM barrel structures nucleotide
binding folds prediction of substrate binding sites Tertiary structure Domains folding denaturation
and renaturation overview of methods todetermine 3D structures Quaternary structure Modular
nature formation of complexes
Unit-IV
Structure-function relationship
DNA-binding proteins prokaryotic transcription factors Helix-turn-Helix motif in DNA binding
Trp repressor Eucaryotic transcription factors Zn fingers helix-turn helix motifs in homeodomain
Leucine zippers Membrane proteins and receptors bacteriorhodopsin and Photosynthetic reaction
center Immunoglobulins IgG Light chain and heavy chain architecture abzymes and Enzymes
Serine proteases understanding catalytic design by engineering trypsin chymotrypsin and elastase
substrate-assisted catalysis other commercial applications
Unit -V
Identification and analysis of proteins
Identification and analysis of proteins by 2D analysis Spot visualization and picking Tryptic
digestion of protein and peptide fingerprinting Mass spectrometry ion source (MALDI spray
sources) analyzer (ToF quadrupole quadrupole ion trap) and detector
Unit-VI
Tools in proteomics and genomics
Site directed mutagenesis for specific protein function Basic concept for designing a new
proteinenzyme molecule Specific examples of enzyme engineering Tryesyl t RNA synthetase
Dihydrofolate reductase Subtilisin Advantages ndash protein data base analysis ndash methods to alter
primary structure of proteins examples of engineered proteins thermal stability of T4-lysozyme
recombinant insulin to reduce aggregation and inactivation de novo protein design ndash principles and
examples
Text Books
1 Voet D and Voet G Biochemistry Third edn John Wiley and Sons 2001
2 Moody PCE and Wilkinson AJ Protein Engineering IRL Press Oxford UK 1990
3 Branden C and Tooze J Introduction to Protein Structured Second Edition GarlandPublishing
NY USA 1999
4 Creighton TE Proteins Freeman WH Second Edition 1993
BT-7222 Elective ndash Quality Management Unit-I
Quality Concepts
Definition of Quality Dimensions of Quality Quality Planning Quality costs ndash Analysis
Techniques for Quality Costs Evolution of Quality Control Basic concepts of Total Quality
Management Historical Review Leadership ndash Concepts Role of Senior Management Quality
Council Quality Statements Strategic Planning Deming Philosophy Barriers to TQM
Implementation Control on Purchased Product Procurement of various products evaluation of
supplies capacity verification Development of sources procurement procedure Manufacturing
Quality Methods and techniques for manufacture inspection and control of product quality in sales
and services guarantee analysis of claims
Unit-II
Quality Management
Organization structure and design quality function decentralization designing and fitting
organization for different type products and company economics of quality value and contribution
quality cost optimizing quality cost seduction program Human Factor in quality Attitude of top
management cooperation of groups operators attitude responsibility causes of apparatus error and
corrective methods
Unit-III
Control Charts
Theory of control charts measurement range construction and analysis of R charts process
capability study use of control charts
Attributes of Control Chart
Defects construction and analysis of charts improvement by control chart variable sample size
construction and analysis of C charts
Unit -IV
Defects diagnosis and prevention defect study identification and analysis of defects correcting
measure factors affecting reliability MTTF calculation of reliability building reliability in the
product evaluation of reliability interpretation of test results reliability control maintainability zero
defects quality circle
Unit-V
Statistical process control
The seven tools of quality Statistical Fundamentals ndash Measures of central Tendency and Dispersion
Population and Sample Normal Curve Control Charts for variables and attributes Process
capability Concept of six sigma New seven Management tools
Unit-VI
Quality system
Need for ISO 9000 and Other Quality Systems ISO 90002000 Quality System ndash Elements
Implementation of Quality System Documentation Quality Auditing QS 9000 ISO 14000 ndash
Concept Requirements and Benefits
Text Books
1 Lt Gen H Lal ldquoTotal Quality Managementrdquo Eastern Limited 1990
2 Greg Bounds ldquoBeyond Total Quality Managementrdquo McGraw Hill 1994
3 Menon HG ldquoTQM in New Product manufacturingrdquo McGraw Hill 1992
4 Dale HBesterfiled et at Total Quality Management Pearson Education Asia 1999
5 James REvans amp William MLidsay The Management and Control of Quality (5thEdition)
South-Western (Thomson Learning) 2002 (ISBN 0- 324-06680-5)
6 FeigenbaumAV ldquoTotal Quality Management McGraw-Hill 1991
7 OaklandJS ldquoTotal Quality Management Butterworth ndash Hcinemann Ltd Oxford 1989
8 Narayana V and Sreenivasan NS Quality Management ndash Concepts and Tasks New Age
International 1996
9 Zeiri ldquoTotal Quality Management for Engineers Wood Head Publishers 1991
BT-722 5 ElectivendashDesign and Development of Biological Treatment process
Unit-I
Bacterial metabolism in wastewater treatment systems
Introduction decomposition of organic carbon compounds in natural and manmade systems aerobic
and anaerobic decomposition of glucose protein carbohydrates proteins lipids etc Nitrogen
removal during treatment enhanced biological phosphate removal biological removal bio-
transformations and biosorption of metal ions aerobic and anaerobic degradation of xenobiotics
Unit-II
Activated sludge process
Single and two stage process special developments technological and microbiological aspects plant
configurations design
Unit-III
Modeling of aerobic waste water treatment process
Introduction purpose of modeling activated sludge model presentations waste water characteristics
various disinfection methods for waste water
Unit-IV
High rate anaerobic waste water treatment
Introduction basic principles reactor design parameters reactor operation
Unit-V
Biological Nutrient removal
Suspended growth and attached growth nutrient removal processes and design criteria ndash Nitrogen
(Nitrification and denitrification) and Phosphorus precipitation biological) Biological removal of
toxic and recalcitrant organic wastes
Unit-VI
Water reuse
Wastewater reclamation risk assessment various reclamation technologies storage agricultural
reuse industrial reuse groundwater recharge
Text book
1 Joumlrdening HJ and JWinter Environmental Biotechnology - Concepts and Applications
Cambridge University Press 2006
2 George Tchobanoglous and Franlin L Burton Wastewater Engineering- Treatment Disposal and
Reuse Tata McGraw Hill Publishing Co Ltd 1990
BT-722 6 Elective ndash Bioinformatics
Unit I
Introduction to Biological Databases Types Overview of Biological Databases and Retrieve
Nucleic acid databases NCBI PubMed Entrez Blast OMIM Books Taxonomy Structure
Locuslink Protein Databases- Primary Functional Composite Secondary Structural classification
database Sequence Formats amp storage Sequence submission to sequence Database
Unit II
Genomics Structure of DNA Polymorphisms in DNA Sequence Human Genome Project
Complete Genome Sequences Functional Annotation
Unit III
Human Genetic Variation Databases and Concepts Introduction Forms and mechanisms of
genetic variation Databases of human genetic variation SNP databases Mutation databases Genetic
marker and microsatellite databases Nonnuclear and somatic mutation databases Tools for SNP and
mutation visualization
Unit IV
Biological Sequence Analysis amp Characterization Predictive Functional Analysis of coding and
non-polymorphisms Amino Acid Properties and Consequences of Substitutions
Unit V
Genetics Genomics Interfaces Technologies for the measurement of gene expression The Cancer
Genome Anatomy Project (CGAP) The Human Transcriptome Map Protein Interaction Networks
Computational methods for pathways and systems biology databases and web resources
Unit VI
Soft computation Neural Networks and Machine learning support vector machines fuzzy logic
evolutionary computing genetic algorithms- applications to data mining and bioinformatics
Text Books
1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves Noah Hardy
ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd
2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-81-8318minus831minus9
Himalaya Publication House Discovering Genomics Proteomics and Bioinformatics Campbell
ISBN978813171 5598 Pearson Education
3 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya Publication House
4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978- 3-527-30541-4
John Wiley amp Sons India Pte Ltd
5 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003
6 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor Laboratory 1st edition
2004
7 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by Andreas D
Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition 2004
8 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st edition (2003)
9 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer Pearson education
First edition (2004)
BT-723 Self Study Open Area Seminar-II
BT-724 Minor Project- II
BT-725 Major Project- I
SEMESTER IV
BT-821 Major Project- II
1
Scheme of Examination amp Syllabus
MTech in Bioinformatics
Delhi Technological University
Main Bawana Road
Delhi -110042
2
MTech in Bioinformatics
Bioinformatics is an emerging discipline of biological science and computer science
mathematics and statistics with the objectives of developing tools to analyze several types
of biological data and generate new knowledge for existing life in universe
Bioinformatics has two subfields the development of computational tools and databases
and the application of these tools and databases in generating biological knowledge to
better understanding living systems These fields are complementary to each other The
tools development includes writing software for sequence structural and functional
analysis as well as construction and curating of biological databases
It is clear that the promise of bioinformatics and advanced level RampD in its field will be
fulfilled by those who have sound background of Biological science computer science
mathematics and statistics The proposed syllabus has been developed to address the
need of well trained bioinformaticians cutting edge RampD for this field bioinformatics
entrepreneurship and bioinformatics-business management The trained manpower will
be well versed in techniques of modern biology biochemistry strong skills in
combinatorial computing and search and retrieval techniques in large biological
databases
3
Delhi Technological University Delhi
Department of Biotechnology
Scheme of Examination
MTech in Bioinformatics
Semester I
Sem I Course
Code
Subject
L T P Internal
Marks
End
sem
Marks
Total
Marks
Credits
Group A BT-501 Advanced Proteomics 3 0 0 50 100 150 3
BT-502 Bioinformatics I 3 0 0 50 100 150 3
BT-503 Population Genetics 3 0 0 50 100 150 3
BT-504 Bioinformatics I
Laboratory
0 0 2 30 70 100 2
Group B BT-551 Biostatistics 3 0 0 50 100 150 3
BT-552 High-Throughput
Structural Biology
3 0 0 50 100 150 3
BT-553 High-Throughput
Structural Biology
Laboratory
0 0 2 30 70 100 2
BT-554 Self Study Open Area
Seminar
0 0 1 50 -- 50 1
Total 360 640 1000 20
4
Semester II
Semester III
Course
Code
Subject
L T P Internal
marks
End
sem
marks
Total
Marks
Credits
Group E BT-701 Professional Elective V 3 0 0 50 100 150 3
BT-702 Professional Elective VI 3 0 0 50 100 150 3
BT-703 Self Study Open Area
Seminar
0 0 2 100 --- 100 2
BT-704 Minor Project - II 0 0 2 -- 300 300 6
BT-705 Major Project-I 0 0 4 300 300 6
Total 200 800 1000 20
Course
Code
Subject
L T P Internal
Marks
End
sem
Marks
Total
Marks
Credits
Group C BT-601 Bioinformatics II 3 0 0 50 100 150 3
BT-602 Professional Elective I 3 0 0 50 100 150 3
BT-603 Professional Elective II 3 0 0 50 100 150 3
BT-604 Bioinformatics II
Laboratory
0 0 2 30 70 100 2
Group D BT-651 Professional Elective III 3 0 0 50 100 150 3
BT-652 Professional Elective IV 3 0 0 50 100 150 3
BT-653 Lab based on Elective
III
0 0 2 30 70 100 2
BT-654 Minor Project ndash I 0 0 1 50 -- 50 1
Total
360 640 1000 20
5
Semester IV
Subject
Code
Subject
L T P Internal
marks
End sem
marks
Total
marks
Credits
Group F BT-801 Major Project - II 0 0 15 400 600 1000 20
Total
400 600 1000 20
BT-602 Professional Elective I
BT-6021 Biological Database Management
BT-6022 Advanced Genetic Engineering
BT-6023 Web Application Development
BT-603 Professional Elective II
BT-6031 Computational Genomics
BT-6032 Drug Design and Discovery
BT-6033 Chemoinformatics
BT-651 Professional Elective III
BT-6511 Computer Aided Drug Design
BT-6512 Computer Graphics
BT-6513 Pharmacogenomics and Personalized Medicine
6
BT-652 Professional Elective IV
BT-6521 Combinatorial Methods in Biopharmaceuticals
BT-6522 Data Warehousing and Data mining
BT-6523 Genomics From Human Genome Project to Medical Applications
BT-653 Professional Elective-III Laboratory
BT-6531 Computer-Aided Drug Design Laboratory
BT-6532 Computer Graphics Laboratory
BT-6533 Pharmacogenomics and Personalized Medicine Laboratory
BT-654 Minor Project-I
BT-701 Professional Elective V
BT-7011 Immunoinformatics
BT-7012 Medical Bioinformatics
BT-7013 Advanced Genetic Engineering
BT-702 Professional Elective VI
BT-7021 Nanotechnology in health care
BT-7022 Resource Planning amp Management in Bioinformatics
BT-7023 Advanced Drug Delivery Systems
7
SYLLABUS
MTECH (BIOINFORMATICS)
Semester I
Group-A
BT-501 Advanced Proteomics
Unit I
Introduction The proteome and the Genome life and death of a protein protein a
modular structure functional protein families need for proteomics scope of proteomics
challenges of proteomics Strategies for protein separation Two-dimensional
polyacrylamide gel electrophoresis for proteome analysis Brief history of 2-DE 2-DE
with immobilized pH gradients sample preparation solubilization Reduction The first
dimension IEF with IPG Equilibration between dimensions The second dimension
SDS-PAGE resolution reproducibility of 2-DE liquid chromatography in proteomics
Unit II
Detection of proteins in polyacrylamide gels and on electroblot membranes Organic
dyes and silver stains Reverse stains Colloidal dispersion stains organic fluorophore
stains metal chelate stains Image analysis of two-dimensional gels Data acquisition
digital image processing Protein spot detection and quantification Gel matching Data
analysis data presentation data bases
Unit III
Enhancing high-throughput proteome analysis the impact of stable isotope labeling
Sample preparation two-dimensional gel separation and analysis Mass spectrometry
8
protein identification using MS data Mass spectrometry protein identification using
MSMS data Protein modification in proteomics Introduction phosphor-proteins
glycoproteins Ubiquitin etc
Unit IV
Protein-Protein interactions- Yeast two hybrid Co-Precipitation Phage Display
Phylogenetic Profile Domain fusion Gene Neighborhood Gene Cluster Mirror Tree
Analysis of genome wide Protein-Protein Interactions in yeast Genome wide yeast two
hybrid analysis of other organisms Protein fragment complementation assays
Unit V
Protein chips and functional proteomics Introduction different types of protein chips
detection and quantification of proteins bound to protein chips emerging protein chips
technologies
Unit VI
Applications of Proteome analysis Mining proteomes protein expression profile
identification of protein-protein interactions and protein complexes mapping proteins
complexes recent advances in Proteomics
Reference Books
1 Proteomics From Protein Sequence to Function by SR Pennington and MJ
Dunn Viva Books Private Limited (2001)
2 Introduction to Proteomics by Daniel C Liebler Humana Press
3 Discovering Genomics Proteomics amp Bioinfo AM Campbell CSH
Press(2003)
4 Handbook of Comparative Genomics Principles and Methodology by Cecilia
Saccone Graziano Pesole Wiley-LISS Publication (2003)
5 Comparative Genomics by Melody S Clark Kluwer Academic Publishers (2001)
9
BT -502 Bioinformatics I
Unit I
Introduction to Biological Databases Types Overview of Biological Databases and
Retrieve Nucleic acid databases NCBI Protein Databases- Primary Functional
Composite Secondary Ensembl Sequence Formats amp storage Sequence submission to
sequence Database
Unit II
Genomics Structure of DNA Polymorphisms in DNA Sequence Types of SNPs
Human Genome Project Genetic Association Studies HapMap Project
Unit III
Protein Functional Annotation and Characterization Gene Ontology GO
Annotations Manual Annotations Computational Annotation Methods Functional
Analysis of Datasets
Unit IV
Pairwise Sequence Alignment Local alignment Global alignment Scoring matrices
PAM BLOSUM Gaps Dot Plots Dynamic programming Approach Needleman and
Wunsch Algorithm Smith and waterman Algorithm Heuristic Approach BLAST
FASTA
Unit V
Multiple Sequence Alignment and Phylogenetic Analysis Algorithms for multiple
sequence alignments global and local alignment programs and methods for multiple
sequence alignment Algorithms for alignment Phylogenetic Analysis
Unit VI
Introduction to Perl Programming Introduction and Installation Arithmetic and
10
Logical operators Conditionals and Loops List and Arrays Working with files
Reference Books
1 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003
2 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor
Laboratory 1st edition 2004
3 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by
Andreas D Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition
2004
4 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st
edition (2003)
5 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer
Pearson education First edition (2004)
6 Beginning Perl for Bioinformatics James Tisdall OrsquoReilly 1st Edn 2001
BT -503 Population Genetics
Unit I
Introduction Scope amp Premises of Population Genetics Genetic and Phenotypic
Variation Random Mating Loci and alleles Mutations and Polymorphisms Genotype
and Allele Frequencies Effect of Mutations on Fitness Rate of Spontaneous Mutation
Unit II
Population Structure The Hardy-Weinberg Principle Testing for Hardy-Weinberg
Equilibrium Extensions of the Hardy-Weinberg Principle Linkage and Linkage
Disequilibrium Genetic Drift The Wright-Fisher Model of Random Genetic Drift
Effective Population Size Gene Trees and Coalescence Mutation The Neutral Theory
Recombination Migration Inbreeding and Heterosis Darwinian Selection Selection in
Haploid Organisms Selection in Diploid Organisms Overdominance More Complex
Types of Selection Molecular Population Genetics Molecular Polymorphisms Patterns
of Change in Nucleotide and Amino Acid Sequences Polymorphism and Divergence
11
Molecular Phylogenetics Transposable Elements mtDNA Y-DNA Separating History
from Gene Flow
Unit III
Population Genomics and proteomics Genome-Wide Patterns of Polymorphism
Human Population Genetics Human Polymorphism Population Genetic Inferences from
Human SNPs Population Structure Inferred from Human Polymorphism Mendelian
Disease and Population Genetics Genetic Basis for Variation in Risk of Complex
Disease Human Origins
Unit IV
Evolutionary Analysis Quantitative Genetics Quantitative Genetics of Natural
Populations Quantitative Trait Loci (QTLs) Types of Quantitative Traits Genes That
Affect Quantitative Traits the Number of Genes Affecting Quantitative Traits Methods
for Mapping QTLs
Unit V
Selection Measures of Fitness amp Constant Fitness Models Nonrandom Mating Identity
by descent Inbreeding Selection on Quantitative Traits Pleiotropy and Developmental
Constraints Interactions of selection with other evolutionary forces The Shifting Balance
Theory The Unit of Selection Meiotic and Molecular Drive Sexual Frequency amp
Density Dependent Selection
Unit VI
Genetic Variability in Natural Populations Introduction Measures of Genetic
Variation Gene Diversity within Populations- Enzyme and Protein Loci Blood Groups
and other loci Genetic Diversity in Subdivided Populations Mechanisms of Maintenance
of Protein Polymorphisms Overdominance hypothesis Other types of Balancing
Selection Neutral Mutations Transient Polymorphisms due to selection
Reference Books
12
1 Evolutionary Analysis Scott Freeman John C Hendon Fourth Edition Pearson
Education
2 Molecular Genetic Analysis of Populations Hoelzel 2nd Edition Oxford
University 1998
3 Genetics -Principles and Analysis Hartl and Jones 5th edition Jones and Barlet
2001
4 Genetics of Populations P W Hedrick 2nd Edition Jones amp Bartlett 2000
5 Principles of Population Genetics Hartl amp Clark Third Edition Sinauer
Associates Inc 1997
BT-504 Bioinformatics-I Laboratory
1 Inter-conversion different sequence file format
2 Database Searching using Entrez and SRS
3 Study of Databases and Data retrieval
4 Dot Matrix Alignments
5 Needleman Wunsch Alignments
6 Smith Waterman Alignments
7 Multiple Sequence Alignment
8 Phylogenetic Analysis
9 Perl Programs
13
Group B
BT-551 Biostatistics
Unit 1
Random variable and Expectation Random variable and distribution function Jointly
distributed random variables Mathematical expectation Statistical parameters Moment
generating function Chebyshevrsquos inequality
Unit 2
Probability Distributions Binomial distributions Multinomial distribution Geometric
distribution Poisson distribution Normal distribution Normal distribution as limiting
case of Binomial distribution Exponential distribution
Unit 3
Correlation and Regression Method of least square and curve fitting Correlation Karl
Pearsonrsquos coefficient of linear correlation Probable error Rank correlation and
Spearmanrsquos coefficient Regression
Unit 4
Sampling distributions and Large sample estimation Sampling plans Statistics and
sampling distributions The central limit theorem The sampling distribution of the
sample mean The sampling distribution of the sample proportion Tests of significance
Large samples testing Sampling of attributes
Unit 5
Exact sampling distributions and small sample test The Chi-square distribution
Studentrsquos t-distribution Snedecorrsquos F- distribution Their Properties and applications
14
Unit 6
ANOVA One - way analysis of variance Two - way analysis of variance Three - way
analysis of variance
Reference Books
1 Pagano M and Gaureau K lsquoPrinciples of Biostatisticsrsquo 7th ed Thomson
Learning2007
2 Ross SM lsquoProbability and Statistics for Engineers and Scientistsrsquo 3rd ed
Academic Press 2005
3 Walpole RE Myers RH MyersSL Ye K lsquoProbability and Statistics for
Engineers and Scientistsrsquo Prentice Hall Inc 2002
4 Taneja HC lsquoStatistical Method for Engineering and Sciencesrsquo IK
Intenational2009
BT-552 High-Throughput Structural Biology
Unit I
Introduction Peptide Bonds hydrogen bonding ionic and hydrophobic interactions
Protein Structure Reverse Turns and Organized Folds Structure Classification Folding
Mechanisms Bond lengths bond angles and torsion angles Degrees of freedom Cyclic
molecules Rotation about a bond Eulerian angles Helices and their notations Analysis
and manipulation of structures Ramachandran plots Chaperones and Chaperonins
Structure Determination Dynamics Simulation Protein Folding Nucleic Acid Structure-
DNARNA Structural Biology for the Optimization of Gene Therapy Vectors Hands-on
assembly of amino acid and nucleotide dimer CPK models
Unit II
X-Ray Crystallography Computing amp NMR Structure Determination X-ray
Crystallography Computing The Phase Problem Least Square Solutions Entropy
Maximization Indirect Methods NMR Structure Determination Nuclear Magnetic
Resonance Distance Geometry Distance-based Modeling Structural Analysis
15
Unit III
Optical spectroscopy Absorbance spectrum and melting of a protein circular
dichroism molecular chirality structural transitions of macromolecules and analysis of
spectral results ligand binding and cell sorting Circular dichroic spectrum and melting
of a protein radiation radioactive decay particle detection liquid scintillation surface
plasmon resonance Thermodynamics of macromolecular transitions Mass spectroscopy
application to complex proteins Diffraction overview crystallization wavevector math
and scattering scattering from a periodic lattice reciprocal space and symmetry
multiwavelength anomalous diffraction and crystallographic statistics
Unit IV
Potential Energy Minimization Potential Energy Function Local Optimization Global
Optimization Energy Transformation
Unit V
Molecular Dynamics Simulation Equations of Motion Initial-Value Problem
Boundary-Value Problem Normal Mode Analysis
Unit VI
Knowledge-based Protein Modelling SequenceStructural Alignment Fold
RecognitionInverse Folding Knowledge-based Structural Refinement Structural
Computing Comparative and ab initio modelling
Reference Books
1 Principles of Biochemistry D L Nelson and MM Cox Lehninger W H
Freeman Fourth Edition 2004
2 Structural Genomics and High-Throughput Structural Biology Michael
Sundstroumlm Martin Norin Aled Edwards CRC Press 2006
3 The Physical Basis of Biochemistry The Foundations of Molecular Biophysics
PR Bergethon Springer Corrected edition 2000
16
4 Principles of Physical Biochemistry KE van Holde CJohnson and PShing Ho
Prentice Hall Second edition 2005
5 Lecture Notes on Computational Structural Biology Zhijun Wu World Scientific
Publishing Co Pte Ltd 2008
BT-553 High-Throughput Structural Biology Laboratory
1 Chemical modification of proteins
2 Peptide mapping
3 Analysis of amino acid composition
4 Analysis and interpretation of spectrophotometric data for denaturation studies
5 Analysis of CD data
6 Analysis and interpretation of NMR data
7 Crystallization of Lysozyme ndash pH driven and salt driven crystallization Effect of
concentration BMCD
8 Analysis and interpretation of X-Ray crystallographic data
9 Public domain software for structure modeling and visualization
BT -554 Self Study Open Area Seminar
17
Semester II
Group C
BT-601 Bioinformatics II
Unit I
Human Genetic Variation Databases of human genetic variation SNP databases
Mutation databases Tools for SNP and mutation visualization
Unit II
Biological Sequence Analysis amp Characterization Predictive Functional Analysis of
coding and non-polymorphisms Amino Acid Properties and Consequences of
Substitutions
Unit III
Genotype-Phenotype Mapping Relationship between genotypes and phenotypes
Genetic programming and its influence on phenotypes Monogenic and complex
disorders Interplay of genetic and environmental factors Integration of clinical and
molecular data Understanding the factors influencing disease susceptibility
Unit IV
Soft computation Machine learning Supervised and Unsupervised Methods Artificial
Neural Networks support vector machines fuzzy logic applications to data mining and
bioinformatics
18
Unit V
Pharmacogenomics and Pharmacogenetics Introduction Pharmacogenetics Drug
Response Single Nucleotide Polymorphism Case Study Pharmacogenomics Databases
OpenPGx Consortium
Unit VI
Bioinformatics Applications and Case Studies Novel Data Annotation and Curation
Pharmacogenomics Applications Database Creation Development of a Predictive Tool
Reference Books
1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves
Noah Hardy ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd
2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-
81-8318minus831minus9 Himalaya Publication House
3 Discovering Genomics Proteomics and Bioinformatics Campbell
ISBN978813171 5598 Pearson Education
4 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya
Publication House
5 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978-3-
527-30541-4 John Wiley amp Sons India Pte Ltd
BT-602 Professional Elective I
BT-6021 Biological Database Management
Unit I
Introduction to Database Systems Overview File Systems vs DBMS Advantages of
DBMS Describing and Storing Data in DBMS Queries in a DBMS Structure of a
DBMS Exercises
19
Unit II
Relational Databases for Bioinformatics Relational Queries Relational Algebra amp
Calculus SQL Queries Programming amp Triggers Query by Example From relational
algebra to SQL
Unit III
Data Storage and Indexing File Organizations amp Indexes Tree-Structured amp Hash-
Based Indexing
Unit IV
Introduction to biological databases Nucleic acid and protein sequence data banks
GenBank EMBL DDBJ TrEMBL GenPept nucleotide sequence databank cDNA
databanks AIDS Virus sequence data bank rRNA data bank NBRF-PIR SWISSPROT
Signal peptide data bank etc
Unit V
Design of Biological Database System for Bioinformatics Schema Refinement amp
Normal Forms Physical Database Design amp Tuning Database Security amp Access
Control
Unit VI
Advanced DBMS Topics Parallel amp Distributed Databases Internet Databases Data
Mining Object-Database Systems Spatial Data Management
Reference Books
1 Database System Concept By CJ Date
2 Database System By Aho Ullman
3 Database Systems By Rob Coronel
4 Database Management Systems Raghu Ramakrishnan amp Johannes Gehrke
Second Edition
20
5 Database Modeling and Design Logical Design Toby J Teorey Sam S
Lightstone Tom Nadeau Publisher Morgan Kaufmann 4th Edition 2005
BT-6022 Plant Bioinformatics
Unit I
Plant Databases and Resources NCBI MIPS TAIR ArEnsEMBL Legume Maize
and Barley Resources
Unit II
Methods for Analysis of Gene Expression in Plants MPSS Classification of mRNA
Signatures Genomic Database MPSS Expression Database
Unit III
Metabolomics Data Analysis Visualization and Integration GC-MS HPLC-MS and
UPLC-MS Metabolic Profiling Methods
Unit IV
KEGG Bioinformatics Resource for Plant Genomics Research Pathway Maps
SSDB EXPRESSSION BRITE LIGAND GENOME
Unit V
Automated Discovery of Single Nucleotide Polymorphism and Simple Sequence
Repeat Molecular Genetic Markers SSR Discovery SNP Discovery SSRPrimer
SNPServer
Unit VI
Methods for Gene Ontology Annotation Web Sites for Browsing GO GO
Annotations Manual Annotations Computational Annotation Methods Functional
Analysis of Datasets
21
References
1 Plant Genomics Methods and Protocols Daryl J Somers Peter Langridge and J
Perry Gustafson Humana Press 2009
2 Plant Bioinformatics Methods and Protocols David Edwards Humana Press
2007
3 Biotechnology in Agriculture and Forestry Plant Metabolomics K Saito RA
Dixon and LWillmitzer Springer-Verlag Berlin Heidelberg 2006
4 Plant Genomics and Proteomics CHRISTOPHER A CULLIS John Wiley amp
Sons Inc 2004
5 Data Mining for Genomics and Proteomics Darius M Dziuda John Wiley amp
Sons Inc 2010
BT -6023 Web Application Development
Unit I
Perl Programming
Introduction and Installation
Unit II
Data types Arithmetic and Logical operators Conditionals and Loops List and Arrays
Working with files Regular Expression and Pattern Matching Bioperl installation and
any two related modules
Unit III
MySQL CGI and PHP Installing MySQL MySQL Programs Working with Data
MySQL Privileges
Unit IV
MySQL and Perl Perl DBI Connect Statement Handles Error Handling Server
Admin
22
Unit V
Apache Understanding Apache Installation Configuration
Unit VI
Database Creation using Perl Apache amp MySQL
Reference Books
1 Perl and Apache Adam McDaniel Wiley Publishing Inc 2010
2 Beginning Perl for Bioinformatics James Tisdall OrsquoReilly 1st Edn 2001
3 Developing Web Applications with Apache MySQL memcatched and Perl
Patrick Galbraith Wiley Publishing Inc 2009
4 Beginning Perl Development Steve Suehring Springer-Verlag New York Inc
2006
5 Database Management Systems Raghu Ramakrishnan amp Johannes Gehrke
Second Edition
BT-603 Professional Elective II
BT-6031 Computational Genomics
Unit I
DNA Sequencing Principles of DNA sequencing Pyrosequencing Automated DNA
sequencing Shotgun sequencing ndash contig assembly High through put sequencing
Double Digest Problem DNA double digest problem multiple solutions to double
digest problem Algorithm for DDP- Integer programming Partition problem and
travelling salesman problem probed partial digest problem homometric sets
23
Unit II
Cloning and clone libraries libraries by complete and partial digestion Gene mapping
mapping with unique and non-unique probes optical mapping interval graphs mapping
with restriction fragment fingerprints Lander-Waterman statistics screening clone
libraries radiation hybrid mapping
Unit III
Genome mapping Commonly Used DNA Markers SNPs or single nucleotide
polymorphisms Genetic Mapping and Physical Mapping alternating Eulerian cycles
transformations in Eulerian cycles Radiation maps STS NCBI and Map Integration
NCBIs Map Viewer Human Genome DNA analysis for health care Study of Model
Species
Unit IV
Functional Genomics DNA arrays sequencing by hybridization (SBH) positional
sequencing by hybridization SBH and the shortest superstring problem SBH and the
Eulerian path problem probability of unique sequence rearrangements string
rearrangements design of DNA microarrays fidelity probes for DNA arrays ESTs
Digital Northerns SAGE Relational Data Base cDNA Microarrays Oligonucleotide
Microarray Chips Cancer and Genomic microarrays Examples for application of
Microarrays Microarrays Data Analysis Gene finding tool
Unit V
Gene expression analysis Gene Control in Prokaryotes and Eukaryotes Structural
Motifs in Eukaryotic Transcription Factors Softwares for Motif Finding SAGE
SAGEmap GEO Profiles GEO DataSets GEO BLAST GEO DataSet Cluster Analysis
Gene Expression Data Analysis cDNA ESTs dbEST and Gene expression study
24
Unit VI
Gene prediction
Gene finding composition based finding sequence motif-based finding Finding of ORF
CpG Island Exons-Introns boundaries Splice site Homology Ab initio gene prediction
program Type of Gene prediction methods and algorithms Eukaryotic gene finding
Gene model in most gene finders Promoter Region Transcriptions Factor and Signals
GENSCAN FGENESH FGENES Promoter recognition programs TSSG NSITE
Pattern Search program Motif representation consensus regular expressions PSSMs
Markov models Other features of nucleic acid sequencing Protein motifs amp domains
Reference Books
1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves
Noah Hardy ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd
2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS
ISBN978minus81minus8318minus831minus9 Himalaya Publication House
3 Discovering Genomics Proteomics and Bioinformatics Campbell
ISBN97881317155 98 Pearson Education
4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978-3-
527- 30541-4 John Wiley amp Sons India Pte Ltd
5 Introduction to Computational Genomics A Case Studies Approach Nello
Cristianini Matthew W Hahn ISBN-139780521671910 Cambridge University
Press India Private Limited
BT-6032 Drug Design and Discovery
Unit I
Drug Discovery Organized Drug discovery and development Source of drugs
Pharmacological Microbial Recombinant Biochemical and Molecular level screening
systems and their construction strategies
25
Unit II
Approaches to New Drug Discovery Alternative strategies in Lead identification Lead
optimization Preclinical development Clinical trials Patenting and clearance for
application
Unit III
Enzymes as Targets of Drug Design Enzyme kinetics Enzyme inhibition and
activation Approaches to the Rational Design of Enzyme Inhibitors Structures of
enzyme stereochemistry of substrate binding site concept of subsites design of substrate
analogs structure based design of inhibitors enzyme inhibitor interactions binding
constant lock and key mechanism induced fit mechanism inhibitors as drug enzyme
inhibitor complexes recognition of new elements in the binding site development of
tight inhibitors Enzyme kinetics Enzyme inhibition and activation Approaches to the
Rational Design of Enzyme Inhibitors
Unit IV
Receptors as Targets of Drug Design Receptor Theory Lead Compound Discovery of
Receptor agonists and antagonists Receptor Complexes and Allosteric Modulators
Molecular Biology of Receptors Receptor Models and Nomenclature Receptor Binding
Assays Lead Compound Discovery of Receptor agonists and antagonists Natural
Product Sources Pharmacophore-based Ligand Libraries Diversity-based ligand
libraries High-throughput screening Receptor versus enzyme mediated drug action SAR
and its quantitative description QSAR Molecular principles in agonist and antagonist
action Thermodynamic and structural principles Objectives and approaches in the native
ligand modification Molecular graphic and dynamical methods in peptide and protein
mimicry Morphinans versus Enkephalins paradigm example of a peptido-mimetic
Other illustrative examples from current literature Drug design by receptor site fit
Active site simulations using PDB structure data and homology modeling Graphical and
computational active site fits exploiting small structure data libraries and commercial
softwares
26
Unit V
Computational Tools and Techniques Homology Model Building Molecular
Mechanics Protein Folding Docking Pharmacophore Models QSAR 3D-QSAR
Quantum Mechanics in Drug Design Cheminformatics
Unit VI
Current status and future prospects Synthetic Peptide libraries Peptide libraries
through Phage Display Applications in Epitope and Agretope mapping and in synth etic
vaccine design Artificial combinatorials Peptides bezodiazepines and other current
examples Selection strategies and screening methodologies Perspectives in Gene
Therapy Human Genome Project and its possible impact Prodrug Design and
Applications
Text Books
1 Comprehensive Medicinal Chemistry C Hansch (Ed) (Vols I-VI) Academic
Press 1990
2 Design of Enzyme Inhibitors as Drugs M Sandler and H J Smith Oxford Univ
Press 1989
3 Drug Discovery and Design Medical Aspects J Matsoukas and T
Mavromoustakos IOS Press 2002
4 Drug Design Cutting Edge Approaches Darren R Flower The Royal Society of
Chemistry Cambridge 2002
5 Protein Folding and Drug Design R A Broglia and L Serrano IOS Press 2007
BT-6033 Chemoinformatics
Unit I
Role of computers in chemical research Introduction to Chemoinformatics
Representation and manipulation of 2D and 3D molecular structures Chemical Databases
- Design Storage amp Retrieval methods
27
Unit 2
Representation of Molecules and Chemical compounds and reactions Different types of
Notations SMILES Coding Structure of Mol files and Sd files( Molecular converter
SMILES Translator)Similarity search of the molecule (Zinc Database)
Unit 3
Reaction databases Representation of chemical reactions Search techniques (Full Sub
and Super structure) Similarity searches Modeling of small molecules
Unit 4
Virtual screening and compound filtering biologically active compounds virtual and
high throughput screening filter functions
Unit 5
Combinatorial chemistry and Library design -Introduction Diversed and focused
Libraries Combinatorial library design strategies Product-based library design Multi-
objective library design
Unit 6
Analysis of high-throughput screening data- Introduction Data visualization Data
mining methods Prediction of ADMET properties QSAR Analysis model building and
model evaluation Chemoinformatics tools for drug discovery
Reference Books
1 Chemoinformatics theory practice amp products by Bary A Bunin Springer
2 Chemoinformaticsa textbook by Johann Gasteiger Wiley
3 Methods in molecular biology volume 201 Combinatorial library methods and
protocol edited by Lisa Bellavance English Humana Press
4 An introduction to chemoinformatics by Andrew R Leach Valerie J Gillet
Kluwer Academic Publishers
28
BT -604 Bioinformatics-II Laboratory
1 SNP and Mutation Databases
2 Gene Ontology
3 Predictive Functional Analysis of SNPs ndash SIFT PolyPhen
4 Pharmacogenomics Databases
BT-651 Professional Elective III
BT-6511 Computer Aided Drug Design
Unit I
Introduction Introduction to CADD SBDD Representation of Molecular Structures
Chemical Nomenclature and Structure Representation Processing Constitutional
Information Representation of 3D Structures Molecular Shape Analysis Representation
of Chemical Reactions
Unit II
Virtual Screening Virtual Screening Chemoinformatics in Lead Discovery
Computational Chemistry Molecular Complexity and Screening Set Design Algorithmic
Engines in Virtual Screening Strengths and Limitations of Pharmacophore-Based Virtual
Screening
Unit III
Lead Discovery High Throughput Screening Hit and Lead Discovery Enhancing Hit
Quality and Diversity within Assay Throughput Constraints Molecular Graphics
Molecular Dynamics and Simulation of Lead Molecular Diversity in Lead Discovery
From Quantity to Quality In Silico Lead Optimization
29
Unit IV
Databases and Libraries Databases and Libraries PubChem PubEchm-BioAssay
Pharma Project Drug Bank WOMBAT World of Molecular Bioactivity Cabinet -
Chemical and Biological Informatics Network Structure Modification in Chemical
Databases Rational Design of GPCR-specific Combinational Libraries Based on the
Concept of Privileged Substructures
Unit V
Molecular docking amp Simulation de novo pharmacophore elucidation drug design for
structurally well-defined receptor targets like HIV protease inhibition ER antagonism
H2 receptor antagonism Chirase inhibition (quinoline derivative antibiotics) and ACE
inhibition macromolecule-ligand docking docking algorithms AUTODOCK Molecular
dynamic simulations relative energy energy minimization methods ligand binding free
energy calculations (both simulation and empirical methods) intermolecular interactions
forces related to drug binding force-field calculation including solvation role of
solubility in drug binding and pKa Poisson-Boltzmann Surface Area (PBSA) AMBER
GROMOS and GROMACS
Unit VI
CADD Applications CADD Applications A Practical Strategy for Directed Compound
Acquisition Efficient Strategies for Lead Optimization Chemoinformatics Tools for
Library Design Hit-to-Lead Process A Users Perspective Application of Predictive
3DQSAR Models to Database Mining Drug Discovery - Case Study
Reference Books
1 Computer Applications in Pharmaceutical Research and Development Wang
Binghe ISBN-10 0-471-73779-8 John Wiley amp Sons India Pte Ltd
2 Engineering Chemistry RV Gadag and A Nityananda Shetty ISBN
8188237833 IK International Publishing House Pvt Ltd
3 Virtual Screening in Drug Discovery Juan Alvarez and Brian Shoichet ISBN-13
978-0824754792 CRC Press
30
4 Biological Thermodynamics Donald T Haynie ISBN9780521704045
Cambridge University Press India Private Limited
5 Chemoinformatics in Drug Discovery Tudor I Oprea Raimund Mannhold Hugo
Kubinyi Gerd Folkers ISBN 978-3-527-30753-1 John Wiley amp Sons India Pt L
BT - 6512 Computer Graphics
Unit I
Graphic Systems Refresh CRT raster-scan displays DVST plasma displays LCD
Unit II
Input devices functions provided by input devices basic working of these input
devices image scanners touch panels Input modes request mode event mode
Unit III
Output Primitives Points lines DDA Bresenham live amp circle drawing algorithm
ellipse generation
Unit IV
Filled area Primitives scan line polygon fill algorithm inside outside tests boundary
fill algorithm Line width color color and gray levels character attributes
Unit V
Two-dimensional Geometric Transformation Basic transformation translation
rotation scaling fixed point scaling general scaling direction The viewing pipeline
window viewpoint transformation Line clipping algorithms
Three Dimensional concepts Polygon surfaces plane equation curved lines and
surfaces quadric surfaces spline representation spline specification Bezier curves and
surfaces B-splines and surfaces Displaying spline curves and surfaces Hornerrsquos rule
31
Three-Dimensional transformation and viewing methods 3 D transformations viewing
co-ordinates transformation from world to viewing co-ordinates parallel and perspective
projections Back face detection depth-buffer and A-buffer methods
Unit VI
3D Object Representation Visible Surface Algorithms Curves and Surfaces in
Computer Graphics Introduction to Ray Tracing and Radiosity methods Anti-aliasing
Shadow generation Texture mapping Effects Fractals Image Coding Color
Reference Books
1 Computer Graphics by DHearn and MP Baker
2 Computer Graphics - A programming approach by Harriyton
3 Procedural Elements of Computer Graphics by Roger
4 Three Dimensional Computer Graphics by Folley and Dam
5 Computer Graphics Principles and Practice James Foley Andries van Dam
Steve Feiner and John Hugues Second Edition
BT-6513 Pharmacogenomics and Personalized Medicine
Unit I
Introduction to Pharmacogenomics The roots of pharmacogenomics Historical
Perspectives and Current Status
Unit II
The Human genome Computational genome analysis
Unit III
Functional Analysis of Gene Variation amp Genotyping Techniques Aspects
influencing method of selection SNP Genotyping TaqMan Genotyping
32
Unit IV
Pharmacogenomics in drug discovery The need of protein structure information
protein structure and variation in drug targets-the scale of problem Mutation of drug
targets leading to change in the ligand binding pocket
Unit V
Case Studies
Unit VI
Management of Pharmacogenomic Information PharmGKB
Reference Books
1 Pharmacogenomics The Search for the Individualized Therapiesrdquo Licinio Julio
and Ma-Li Wong Wiley-VCH 2002
2 Pharmacogenomics An Approach to New Drugs Development Chakrabarthy
Chiranjib and Bhattacharyya Atane 2004
3 Pharmacogenomics Social Ethical and Clinical Dimensions Rothstein Mark A
Wiley-Liss 2003
4 Pharmacogenomics in Drug Discovery amp Development Qing Yan Humana
Press 2008
5 Pharmacogenomics Methods and Protocols Federico Innocenti Humana Press
2005
BT-652 Professional Elective IV
BT -6521 Combinatorial Methods in Biopharamaceuticals
Unit I
Introduction The Original Combinatorial Chemist ndash Biopolymers constitute natural
libraries ndash Selection and evolution ndash The expression of genetic information
33
Combinatorial assembly of antibody genes ndash Molecular solutions to Combinatorial
problems
Unit II
Synthetic Peptide Libraries Solid-Phase peptide synthesis ndash Peptide on pins ndash Other
iterative disconvolution strategies Examples of SplitCoupleMix Peptide Libraries ndash
Positional Scanning
Unit III
Supports Linkers and Reagents for peptide and small molecule synthesis
Polystyrenes ndash PEG ndash Grafted supports ndash Coupling strategies ndash New resins and linkers ndash
Ring ndash forming cleavage ndash loading
Unit IV
Supported Solution ndash Phase Synthesis Polyethylene glycols ndash Dendrimers Fluorous
synthesis ndash Solution ndash Phase parallel synthesis scavenging resins ndash Ion Exchange resins ndash
Supported reagents ndash Flourous reagents ndash Solid phase extraction ndash Gas Phase separation
Unit V
Analytical Methods for Solid-Phase Synthesis Product identification ndash Gel Phase
NMR ndash High resolution magic angle spinning NMR on-bead infrared Spectroscopy ndash
Mass Spectroscopy ndash Non-Spectroscopic Methods- Product identification ndash Gel Phase
NMR ndash High resolution magic angle spinning NMR on-bead infrared Spectroscopy ndash
Mass Spectroscopy ndash Non Spectroscopic Methods
Unit VI
A Combinatorial Approach to Gene Expression Analysis DNA Microarrays DNA
Microarray Components Characteristics and Technology Fabrication Target
Preparation and Labelling Procedures Hybridization and Washing Target Detection
Analysis Applications of the Microarray Technology
34
Reference Books
1 Fenniri Hicham lsquoCombinatorial Chemistryrsquo Oxford University Press 2000
2 Block JH and Beale JM lsquoWilson amp Gisvolds Text book of Organic Medicinal
and Pharmaceutical Chemistryrsquo 11th Edition Lippincott Williams amp Wilkins
2004
3 Fassina G ldquoCombinatorial Chemistry and Technologies Methods and
Applicationsrdquo 2nd Edition CRC Press 2005
4 Combinatorial Chemistry Synthesis Analysis Screening Gunther Jung
WILEY-VCH Verlag GmbH 2001
5 Handbook of Combinatorial Chemistry Drugs Catalysts Materials K C
Nicolaou Wiley-VCH 2002
BT -6522 Data Warehousing and Data Mining
Unit I
Data Warehousing and Business Analysis Data warehousing Components ndashBuilding a
Data warehouse ndash Mapping the Data Warehouse to a Multiprocessor Architecture ndash
DBMS Schemas for Decision Support ndash Data Extraction Cleanup and Transformation
Tools ndash Metadata ndash reporting ndash Query tools and Applications ndash Online Analytical
Processing (OLAP) ndash OLAP and Multidimensional Data Analysis
Unit II
Data Mining Data Mining Functionalities ndash Data Preprocessing ndash Data Cleaning ndash Data
Integration and Transformation ndash Data Reduction ndash Data Discretization and Concept
Hierarchy Generation
Unit III
Association Rule Mining Efficient and Scalable Frequent Item set Mining Methods ndash
Mining Various Kinds of Association Rules ndash Association Mining to Correlation
Analysis ndash Constraint-Based Association Mining
35
Unit IV
Classification and Prediction Issues Regarding Classification and Prediction ndash
Classification by Decision Tree Introduction ndash Bayesian Classification ndash Rule Based
Classification ndash Classification by Back propagation ndash Support Vector Machines ndash
Associative Classification ndash Lazy Learners ndash Other Classification Methods ndash Prediction ndash
Accuracy and Error Measures ndash Evaluating the Accuracy of a Classifier or Predictor ndash
Ensemble Methods ndash Model Section Cluster Analysis - Types of Data in Cluster
Analysis ndash A Categorization of Major Clustering Methods ndash Partitioning Methods ndash
Hierarchical methods ndash Density-Based Methods ndash Grid-Based Methods ndash Model-Based
Clustering Methods ndash Clustering High-Dimensional Data ndash Constraint-Based Cluster
Analysis ndash Outlier Analysis Mining Object Spatial Multimedia Text and Web Data
Multidimensional Analysis and Descriptive Mining of Complex Data Objects ndash Spatial
Data Mining ndash Multimedia Data Mining ndash Text Mining ndash Mining the World Wide Web
Unit V
Microarray Data Mining Practical Factors Prior to Data Mining Differential Gene
Expression Discriminant Analysis Gene Annotation and Pathway Analysis Microarray
Data Mining Applications
Unit VI
Integrative Data Analysis for Biological Discovery Introduction Representative
Selection of Algorithms Application to a specific domain Future trends
Reference Books
1 Jiawei Han and Micheline Kamber ldquoData Mining Concepts and Techniquesrdquo
Second Edition Elsevier Reprinted 2008
2 Alex Berson and Stephen J Smith ldquoData Warehousing Data Mining amp OLAPrdquo
Tata McGraw ndash Hill Edition Tenth Reprint 2007
3 KP Soman Shyam Diwakar and V Ajay ldquoInsight into Data mining Theory and
Practicerdquo Easter Economy Edition Prentice Hall of India 2006
4 G K Gupta ldquoIntroduction to Data Mining with Case Studiesrdquo Easter Economy
36
Edition Prentice Hall of India 2006
5 Pang-Ning Tan Michael Steinbach and Vipin Kumar ldquoIntroduction to Data
Miningrdquo Pearson Education 2007
BT-6523 Genomics From Human Genome Project to Medical
Applications
Unit I
Biotechnology and Genomics in Medicine Gene Medicine Disease Models Impact of
Genomics on Medicine Molecular Medicines
Unit II
Genomics Human Genome Project Breakthroughs Functional Genomics Comparative
Genomics Transcriptomics Proteomics Mutational Genomics
Unit III
Genomics Applications in Infectious Diseases Identification of causative microbes
molecular epidemiology host resistance to infection pathogenicity combating infectious
diseases
Unit IV
Genomics Applications in Genetic Diseases Genetic Disorders detection and treatment
of single gene disorders analysis of polygenic disorders linkage analysis Linkage
disequilibrium mapping haplotypes MHC pharmacogenomics
Unit V
Genomics Applications in Cancer Molecular basis of cancer impact of genomics on
cancer research methods for the diagnosis of cancer approaches to cancer therapy
37
Unit VI
Case Study Cardiovascular Disorders Cardiovascular Single Gene Disorders
Cardiovascular Polygenic Disorders Therapies and Applications
Reference Books
1 Human Molecular Genetics Third Edition (2003) T Strachan and AP Read
Garland Science Publication
2 Molecular Cell Biology Sixth Edition (2007) H Lodish A Berk and CA
Kaiser W H Freeman amp Co Ltd
3 Cardiovascular Genetics and Genomics for the Cardiologist (2007) Victor J Dzau
and Choong-Chin Liew Blackwell Publishing
4 Genomics The Science of Technology Behind the Human Genome Project
(1999) Charles R Cantor and Cassandra L Smith John Wiley amp Sons Inc
5 A Century of Mendelism in Human Genetics (2005) Milo Keynes
AWFEdwards and Robert Peel CRC Press
BT-653 Professional Elective-III Laboratory
BT-6531 Computer-Aided Drug Design Laboratory
1 To perform the homology modeling of a protein by using the MODELLER
software
2 To evaluate the 3D structure of a protein by using the different tools on the SAVS
server
3 To find the active sitecavity in a receptor by using the SURFACE RACER
program
4 To draw the chemical structures by using the ChemSketchChemDraw software
5 To perform the de novo Drug Designing by using the LIGBUILDER software
6 To perform the protein-ligand docking by using the HEX program
7 To perform the protein-protein docking by using the AUTOCOCK software
38
8 To perform the virtual screening of ligands by using the DOCK program
9 To perform the Quantitative Structure-Activity Relationship (QSAR) analysis by
using the DRAGON software
10 To perform the Pharmacophore modeling of ligands by using the LigandScout
program
BT-6532 Computer Graphics Laboratory
1 Standard functions in the c graphics module -Introduction to pixels drawing
various geometric objects filling polygons images etc
2 Implementation of the basic line drawing algorithm and the Circle drawing
algorithm using DDA Midpoint algorithm Bresenhams algorithm etc
3 Polygon filling using seed fill scan line algorithm etc
4 Clipping algorithms -Cohen-Sutherland algorithm LiangBarsky algorithm etc
5 2D and 3D Transformations -Translation scaling rotation etc
6 Projections - Parallel and perspective projections and their types Curve fitting -
Cubic curves (Bezier curves spline curves etc)
7 Lighting and Shading -Implementing Phong illumination model Gouraud and
Phong shading Animation
8 Image processing demonstration
BT-6533 Pharmacogenomics and Personalized Medicine
Laboratory
1 Accessing querying and becoming comfortable with the interface of
pharmacogenomics based databases ndash
a UCSC
b NCBI dbSNP
c HapMap and resequencing databases
d 1000 Genomes
39
e PharmGKB - a publicly available Internet tool to aid researchers in
understanding how genetic variation among individuals contributes to
differences in reactions to drugs
f Drug Bank
2 Use of PGx pipeline 10 Server
3 Statistical data management using SAS
a Data Collection and Entry
b Data Storage and Transferal
c Data Analysis
d Data Exposition USING sas
4 Understand and run Warfarin dosing algorithm using web based interfaces
5 Sequence variation analysis
BT-654 Minor Project-I
BT-701 Professional Elective V
BT-7011 Immunoinformatics
Unit I
Immunology Introduction Overview of the Immune System A Case Study
Classification of Immunity Concepts in Immunology Antigens Antibodies The
Compliment System Antigen-Antibody Reactions The Major Histocompatibility
Complex allele selection Antigen Presentation TAP T cell receptors
Unit II
Advanced Immunology Immune Effector Mechanisms Cytokines and Chemokines
Hypersensitive Reactions The Immune system in Health and Disease Autoimmunity
Transplantation Immunology Classification of Vaccine
40
Unit III
HLA System in model organism Defining HLA Supertypes in HLAndashStructural and
Modeling Principles HLA Super types by GRIDCPCA and Hierarchical Clustering
Methods Structural Basis for HLA-A2 Supertypes Clustering of MHC Peptide-Binding
Repertoires HLA Alleles-Electrostatic Distribution Maps
Unit IV
In Silico Prediction of Immunogenicity Databases Searching An Introduction
MHCDB(NCBI) IMGT The IMGTHLA Database IPD The Immuno Polymorphism
Database SYFPEITHI Database for Searching and T-Cell Epitope Prediction Mapping
of T-Cell Epitopes MHC Binders and TAP Binders Mapping of LinearB-Cell Epitopes
in Bcipep Database Haptens Carrier Proteins and Anti-Hapten Antibodies
Unit V
Predictions Predicting Peptide-MHC Binding PeptidendashMHC Binding Using Profiles
Machine Learning Techniques for MHC Binders Artificial Intelligence Methods for
Predicting T-Cell Epitopes MHC-Class I and II Binding Affinity MHCndash Molecular
Affinity and QSAR Models Support Vector Machine for MHC-Binding Peptides Static
Energy Analysis of MHC Class I and Class II Peptide-Binding Affinity Nonlinear
Predictive Modeling of MHC Class IIndashPeptide Binding Using Bayesian Neural
Networks
Unit VI
Applications Computational vaccinology Viral Bioinformatics Immunogenomics
Mathematical models of HIV and the immune systems
Reference Books
1 Immunology Richard A Goldsby Thomas J Kindt Barbara A Osborne Janis
Kuby WH Freeman amp Company 5th edition Pages 19-504 2003
41
2 Roittrsquos Essential Immunology Ivan M Roitt Peter J Delves Blackwell Science
Ltd 10th Edition 2001
3 Immunoinformatics predicting Immunogenicity in-silico Darren R Flower
Humana Press Pages 1-309
4 Instant Notes in Immunology PM Lydyard A Whelan MW Fanger BIOS
Scientific Publishers Ltd 1st Edition 2003
5 An Introduction to Immunology CV Rao Narosa Publishing House1st Edition
2004
BT-7012 Medical Bioinformatics
Unit I
An Overview Introduction Problems in health care motivating biomedical informatics
Seminal documents and reports Resources of field - organizations information
education
Biomedical Computing Types of Computers Data Storage in Computers Computer
Hardware and Software Computer Networks Software Engineering Challenges for
Biomedical Computing
Electronic Health Records Clinical Data and Workflow History and Perspective of the
Health (Medical) Record Potential Benefits of the Electronic Health Record
Definitions and Key Attributes of the EHR EHR Examples Nursing Informatics
Unit II
Clinical Decision Support EHR Implementation Historical Perspectives and
Approaches Medical Errors and Patient Safety Reminders and Alerts Computerized
Provider Order Entry (CPOE) Implementing the EHR Use and Outcomes of the EHR
Cost-Benefit of the EHR
Standards and Interoperability Privacy Confidentiality and Security Standards
Basic Concepts Identifier and Transaction Standards Message Exchange Standards
42
Terminology Standards Privacy Confidentiality and Security Basic Concepts HIPAA
and Other Countriesrsquo Privacy and Security Regulations
Unit III
Secondary Use of Clinical Data Personal Health Records Health Info Exchange
Public Health Health Care Quality Clinical Research Personal Health Records Health
Information Exchange Public Health Informatics Health Care Quality Clinical Research
Informatics
Unit IV
Evidence-Based Medicine and Medical Decision Making Definitions and Application
of EBM Interventions Diagnosis Harm and Prognosis Summarizing Evidence Putting
Evidence into Practice Limitations of EBM
Unit V
Information Retrieval and Digital Libraries Information Retrieval Knowledge-based
Information Content Indexing Retrieval Evaluation Digital Libraries
Imaging Informatics and Telemedicine Imaging in Health Care Modalities of
Imaging Digital Imaging Telemedicine Definitions and Barriers Efficacy of
Telemedicine
Unit VI
Translational Bioinformatics Translational Bioinformatics - The Big Picture
Overview of Basic Molecular Biology Important Biotechnologies Driving
Bioinformatics Genetics-Related Diseases Bioinformatics Information Resources
Translational Bioinformatics Challenges and Opportunities
Organizational and Management Issues in Informatics Organizational Behavior
Organizational Issues in Failure and Success of Informatics Projects Change
Management
43
Reference Books
1 Handbook of Medical Informatics Jvan Bemmel (Editor) MA Musen (Editor)
Mark Musen (Author) Springer-Verlag published
2 Clinical Decision Support Systems Theory and Practice (Health Informatics) by
Eta S Berner (Editor) M J Ball (Editor) Springer-Verlag New York Inc
3 Computer-Based Patient Record An Essential Technology for Health Care
Revised Edition by Committee on Improving the Patient Record Institute of
Medicine Richard S Dick and Elaine B Steen (Paperback - Jan 1997)
BT-7013 Advanced Genetic Engineering
Unit I
Core techniques in gene manipulation Cutting and joining DNA introduction of DNA
into cells Isolation sequencing and synthesis of gene
Unit II
Cloning strategies construction of genomic libraries and cDNA libraries Probe
construction recombinant selection and screening Analysis of expression Analysis of
recombinant DNA site-directed mutagenesis altered expression and engineering genes
Unit III
DNA amplification using polymerase chain reaction Key concepts Analysis of amplified
products Applications of PCR Ligase chain reaction Expression systems and their
applications Ecoli Streptomyces Yeast Baculovirus and animal cells as cloning hosts
Sequencing methods
Unit IV
Transfection techniques Gene silencing techniques Gene knockouts and gene therapy
Differential gene expression and protein array Protein-protein interactions DNA-Protein
44
interactions Somatic and germ line therapy-in vivo and ex vivo Transgenics
Unit V
Applications of Genetic Engineering Pharming Genetically Engineered Foods
Biofuels Designer Babies
Unit VI
Applications of Bioinformatics in Genetic Engineering Functional Genomics
Analysis of Mutations Applications in Agriculture
Reference Books
1 Principles of gene manipulation by RNOld amp SBPrimrose (1994) Blackwell
Scientific Publications
2 DNA cloning I amp II by DM Glover amp BD Hames (1995) IRL Press
3 PCR stratagies by MA Innis DHGelfand amp JJ Sninskey (1995) Academic Press
4 Concepts in Biotechnology ndash Editors DBalasubramanian et al University Press
(1996)
5 Methods in Molecular Biology vol62 Edited by RSTuan Humana Press
Totowa New Jersey
BT-702 Professional Elective VI
BT-7021 Nanotechnology in Health Care
Unit I
Nanotechnology in Pharmaceutical Applications Human anatomy ndash Form function
and physiology ndash Developmental prolog - principle of development ndash Neurophysiology ndash
sensory physiology and muscle physiology - Trends in nanobiotechnology - Protein- and
45
peptide-based compounds for cancer diabetes infectious diseases and organ transplant-
therapeutic classes- focused pharmaceutical delivery systems
Unit II
Immunoassay Techniques Understanding of antibody-based diagnostic techniques
(immunoassay) - micro- and nano-immunosensors- Bio-Barcode Assay- use of magnets
gold DNA and antibodies- therapies and diagnostics for cancer and central nervous
system disorders
Unit III
Improved Medical Diagnostics Improved diagnostic products and techniques- in vivo
imaging capabilities by enabling the detection of tumors plaque genetic defects and
other disease states-ability to control or manipulate on the atomic scale- Nanobot medical
devices- logic and intelligence embedded into medical devices- standalone sensing and
computing devices
Unit IV
Prosthetic and Medical Plants New generations of prosthetic and medical implants-
artificial organs and implants- artificial scaffolds or biosynthetic coatings-
biocompatibility and reduced rejection ratio- retinal cochlear and neural implants
repair of damaged nerve cells and replacements of damaged skin tissue or bone
Unit V
Methods for Diagnosis Animation of the PCR - DNA Profiling - Cantilever Sensors -
Targeted Drug Delivery - Magnetic Nanoparticles - Cancer cell targeting - Stem Cell
Scaffolds - Electrochemical Impedance Spectroscopy (EIS) - Tethered Lipid Membranes
Reference Books
1 Chemical Sensors and Biosensors Brian R Eggins Wiley New York
Chichester 2002
46
2 Biosensors and modern biospecific analytical techniques Wilson amp Wilsonrsquos
Comprehensive Analytical Chemistry Ed L Gorton Elsevier Amsterdam
London 2005
3 The Immunoassay Handbook Ed David Wild 3rd ed Amsterdam Elsevier
2005
4 Electrochemical Methods Fundamentals and Applications Allen J Bard and
Larry R Faulkner Wiley New York Chichester 2nd ed 2001
5 Ultrathin Electrochemical Chemo- and Biosensors Technology and Performance
in Springer Series on Chemical Sensors and Biosensors Volume Two Ed
Vladimir M Mirsky Springer Berlin 2004
BT-7022 Resource Planning amp Management in Bioinformatics
Unit I
Introduction Fundamentals of Resource management practice
Unit II
Bioinformatics resources-an Introduction Tour to bioinformatics web sites Biological
databases and software an overview Open source movement Bioinformatics Resource
utilization and commercialization Networking and Super Computing resources- world
wide and India specific facilities Clinical applications of bioinformatics
Bioinformatics resource management the key-issues (piracy hacking and data mining)
Data Security and integration in Pharma Industry tools and techniques
Unit III
Bioinformatics Resources as a business practice The bioinformatics market-
Bioinformatics companies and products commercialization of bioinformaticsrsquo resources
funding agencies for bioinformatics projects models of technology transfer amp licensing
47
Unit IV
Commercial amp Financial aspects of Bioinformatics Concepts of software product
Market and process economics Financial appraisal of bioinformatics projects - cash flow
diagram ROR discounted ROR etc Architecture of a typical bioinformatics business
plan
Unit V
TRIPS agreement IPR issues in relation to software products processes Architecture
of Patent application Biotechnology amp Bioinformatics Related issues of Public Concern -
Bioethics
Reference Books
1 ERP Demystified Alexis Leon Tata McGraw Hill 1999
2 Concepts in Enterprise Resource Planning Joseph A Brady Ellen F Monk Bret
J Wangner Thomson Learning 2001
3 BAREACT Indian Patent Act 1970 Acts amp Rules Universal Law Publishing
Co Pvt Ltd 2007
4 Kankanala C Genetic Patent Law amp Strategy 1st Edition Manupatra
Information Solution Pvt Ltd 2007
5 Essentials of Management by H Koontz H Weihrich and C OrsquoDonnell
Publisher McGraw-HillIrwin
6 The Practice of Management by P Drucker Publisher Harper Business
BT-7023 Advanced Drug Delivery Systems
Unit I
Dendrimers- Synthesis -Nanoscale containers- Gene transfection ndash Nanosca foldsystems-
Biocompatibility of Dendromers
Unit II
Microfabricated drug delivery systems ndash Microneedles- Micropumps-Microvalves-
48
Implantable microchips ndash sustained chronic disease
Unit III
Properties of drug targeting delivery systems-ADME hypothesis- site specific drugs-
Synthetic carrier for drugs-liposomes-Antibodies
Unit IV
Targeted Nanoparticles for drug delivery- Polymers nanotubes- Issues for specific disease
will be addressed
Unit V
Virus Based Nanoparticles - Modification by bioconjugation ndash Tumour targetting invivo
ndash use in biomedical Imaging
Reference Books
1 Drug Delivery Engineering Principles for Drug Therapy M Salzman Oxford
University Press 2001
2 Drug Delivery and Targeting AM Hillery CRC Press 2002
3 Drug Delivery Principles and Applications B Wang Wiley Intersceince 2005
BT-703 Minor Project ndash II
BT-704 Major Project - I
BT-705 Self Study
BT-801 Major Project-II
1
Delhi Technological University
Civil Engineering Department
M Tech Syllabus
Various Courses of M Tech (Structure) Programmes in Delhi Technological University
Scheme for M Tech (Structural Engineering) Sem Gp Course Details Course
Code L T P Internal
Marks External Marks
Total Marks
Credits
Ist A Advanced Mathematics amp Numerical Techniques
CE501 3 0 0 50 100 150 3
Finite Element Method of Structural Analysis
CE503 3 0 0 50 100 150 3
Advanced Theory of Structures CE502 3 0 0 50 100 150 3 Structural Engg Laboratory CE504 0 0 2 30 70 100 2
B Theory of Plates amp Elastic Stability CE551 3 0 0 50 100 150 3 Theory of Elasticity amp Plasticity CE552 3 0 0 50 100 150 3 CADD Laboratory CE553 0 0 2 30 70 100 2 Self study Open Area Seminar CE554 0 0 2 50 00 50 1
21Hoursweek 1000 20 IInd C
Structural Dynamics CE601
3 0 0 50 100 150 3
Elective I any one of the following 1 Material Science amp Technology 2 Plastic Analysis of Metallic Styructures 3 Stress Analysis
CE6021 CE6022
CE6023
3 0 0 50 100 150 3
Elective II any one of the following 1 Design of Industrial Structures and
Bridges 2 Design of Tall Buildings 3 Seismic Design of Structures
CE6031
CE6032 CE6033
3 0 0 50 100 150 3
Photo-Elasticity Lab CE564 0 0 2 30 70 100 2 D Elective III any one of the following
1 Design of Structures for Dynamic Loads
2 Prestressed Concrete Design 3 Shells and Folded Plates
CE6511
CE6512 CE6513
3 0 0 50 100 150 3
Elective IV any one of the following 1 Design of Hydraulic Structures 2 Groundwater and Seepage 3 Instrumentation 4 Planning and Design of
Environmental Services
CE6521 CE6522 CE6523 CE6524
3 0 0 50 100 150 3
Str Dynamics Lab CE653 0 0 2 30 70 100 2 Minor Project I CE654 0 0 2 50 00 50 1
21Hoursweek 1000 20 IIIrd E Elective V any one of the following
1 Geotechnical Earthquake Engineering
2 Foundation Engineering 3 Soil Structure Interaction
CE7011
CE7012 CE7013
3 0 0 50 100 150 3
Elective VI any one of the following 1 Advanced Building Construction and
CE7021
3 0 0 50 100 150 3
2
Management 2 Disaster Resistant Structures 3 Soil Dynamics and Geotechnical
Earthquake Engineering
CE7022 CE7023
Self Study open area seminar II CE703 0 0 2 50 00 50 1 Minor Project II CE704 0 0 4 00 200 200 4 Major Project part I CE705 0 0 2 200 00 200 4
18Hoursweek 750 15 IVth F Major Project Part II CE801 3 0 0 00 750 750 15 6Hrswk 750 15 Grand Total 3500 70
Subject Code Subject L T P D MM
CE501 ADVANCED MATHEMATICS AND NUMERICAL TECHNIQUES
3 0 0 0
ADVANCED MATHEMATICS AND NUMERICAL TECHNIQUES Determinants and matrices Solution of linear equations Indeterminacy of structures Influence co-efficient methods Flexibility and Stiffness matrices for statically indeterminate structures Application of Fourier series to beams Complex variables Conformal mapping and Schwartz-Christoffel transformation applied to flow problems Tensor analysis (Cartesian) and its application to simple elastic and plastic problems Differential equations Series solution Bessel functions Legendre Polynomials Partial Differential equations Legendrersquos form Numerical method Finite Differences Numerical integration and differentiation Numerical solution of ordinary differential equations and their application to engineering structures Poissonrsquos Laplacersquos and biharmonic equations Relaxation methods and their application to Civil Engineering problems Advanced Computer programming and its application to Engineering problems
References
BSGrawalrdquo Higher engineering mathematicsrdquo
Jain and lyengar ldquoAdvanced engineering mathematicsrdquo Narosa publishing house
EKreyszig ldquoAdvanced engineering mathematicsrdquo John Wiley amp Sons
Peter OrsquoNeil ldquoAdvanced engineering mathematicsrdquo
Subject Code Subject L T P D MM
CE503 FINITE ELEMENT METHOD OF STRUCTURAL ANALYSIS
3 0 0 0
FINITE ELEMENT METHOD OF STRUCTURAL ANALYSIS
Finite element displacement approach plane stress and plane strain problems Triangular and rectangular elements 2-D and 3-D elements Iso-parametric elements Application to structural problems References
CSKrishnamoorthy Finite element analysis theory and programming Tata McGraw Hill Cook RD Malkus DS and Plesha ME Concepts and Applications of Finite Element Analysis Third Edition John Wiley 1989 OC Zienkiewicz The Finite Element Method McGraw-Hill
KJBathe rdquo Finite Element procedures in Engineering Analysisrdquo Prantice Hall India
3
Abel amp DesairdquoIntroduction to the Finite Element Methodrdquo CBS Publishers
Subject Code Subject L T P D MM
CE502 ADVANCED THEORY OF STRUCTURES 3 0 0 0
ADVANCED THEORY OF STRUCTURES
Flexibility and stiffness methods of structural analysis Analysis using substructure technique effects of axial forces on flexural stiffness Analysis of framed shear wall buildings Non Linear and Elasto-Plastic Analysis Beams curved in plan and elevation Various types of structural systems for tall buildings References
HCMartin Introduction to Matrix Methods of Structural Analysis
Kardestuncer Elementary Matrix Analysis of Structures
Weaver amp Gere Matrix Structural Analysis CBS Publisher
AGahali AM Neville amp Brown ldquoStructural analysisrdquo
Norris Wilbur Utku ldquo Elementry Structural analysisrdquo
BeaufaitRowanHoadley ldquoComputer method of Structural analysis
Subject Code Subject L T P D MM
CE504 STRUCTURAL ENGINEERING LABORATOR 0 0 2 0
Structural Engineering Laboratory
Concrete mix design amp testing Non destructive testing of Concrete testing of RCC Under and Over reinforced Beams Columns under eccentric loading two way reinforced RCC Slabs fracture characteristics of mild steel and cold worked steels
Subject Code Subject L T P D MM
CE551 THEORY OF PLATES AND ELASTIC
STABILITY
3 0 0 0
THEORY OF PLATES AND ELASTIC STABILITY Theory of stability The concept of stability Post buckling behaviour of long slender columns Columns with elastically supported ends Newmarkrsquos formula Columns with spring supports two hinged and fixed portal frames symmetrically loaded Energy and numerical methods of columns Columns with lateral loads Columns with variable sections Effect of shearing force on critical load Inelastic buckling of bars built up columns of varying moments of inertia Lateral buckling of beams
Buckling of Plates Theory of plates Elastic theory of plates rectangular plates with various loading and edge conditions Fourierrsquos series finite differences energy and finite element methods exact theory of plates Circular plates continues plates and approximate methods of analysing rectangular grids Distribution of concentrated loads to the various beams in grid floor and bridge decks
References
SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959
4
K Chandrashekhara Theory of Plates University Press 2001
ACStress in plates and shells
SP Timoshenko JMGere Theory of elastic stability McGraw-Hill 1959
Subject Code Subject L T P D MM
CE552 THEORY OF ELASTICITY AND PLASTICITY
3 0 0 0
THEORY OF ELASTICITY AND PLASTICITY Theory of elasticity Stress tensor equations of equilibrium Kinematic relationships and equations of compatibility Generalised Hookrsquos law Boundary conditions Plane stress and Plane strain Airyrsquos stress function Saint Venantrsquos principal problems in rectangular and polar co-ordinates
Inverse and semi-inverse methods Torsion of prismatic bars Membrane analogy Typical applications
Theory of PlasticityHydro-static and deviatorinc components of stress tensor invariants of stress tensor Tresca-Saint Venants and Henky-von Mises yield conditions Octahedral stresses
Analysis of (I) Bending of bars of narrow rectangular cross section formation of plastic hinge
(II) Torsion of prismatic bars sand heap analogy
(III) Thick Spherical shell- bursting pressure
(IV) Thick cylindrical tube autofrettage
References
SPTimoshenko amp JNGoodier Theory of Elasticity McGraw Hill-1970
MKachanov Theory of Plasticity MIR Publication
CRCalladine Plasticity for Engineers Ellis Horwood Chichester UK 1985
Subject Code Subject L T P D MM
CE553 CADD Laboratory 0 0 2 0
CADD Laboratory
Introduction to computer aided design and drafting Soil structure interaction FEM modelling application to structural engineering problems of Multistoried Buildings Bridges Water Tanks suspension Bridges using commercial softwares such as STAAD-Pro E-TabsSAP NISHA MATLAB Earthquake resistant design and drawing detailing based on IS18932002 IS43261993IS4562000 drawing detailing using AUTOCAD and solid works
Subject Code Subject L T P D MM
CE601 STRUCTURAL DYNAMICS 3 0 0 0
Structural Dynamics
5
Oscillatory motion harmonic motion periodic motion vibration terminology Characteristics of a Dynamic Problem Prescribed Dynamic Loading Definition of Dynamic DOFs Mathematical modeling of dynamic systems Formulation of Equations of motion in Generalized SDOF SDOF MDOF discrete and continuous systems using drsquoAlembertrsquos Principle Principle of Virtual displacements and Variational Approach
Free vibration equations of motion-natural frequency Experimental determination of natural frequencies viscously damped free vibration Coulomb damping Response of SDOF system to harmonic periodic impulsive and general dynamic loading earthquake excitations in time and frequency domain Base excited systems Transmissibility and Vibration isolation Laplace transform formulation energy dissipated by damping equivalent viscous damping structural damping vibration measuring instruments
Free Vibration response of discrete MDOF systems eigen values eigen vectors Approximate methods for obtaining natural frequencies and mode shapes Forced Harmonic Vibration vibration absorber vibration damper Damping in structures
Free and Forced vibration of continuous systems
Concept of Spectral quantities response spectrum Discussion on IS 1893 part I 2000 codal provisions Response of linearly elastic systems using modal analysis
References
WTThomson Theory of Vibration with Applications Pearson Education
RW Clough amp JPenzien ldquoDynamics of Structures McGraw Hill
JLHumar ldquo Dynamics of Structurerdquo Prantice Hall
JW Smith ldquo Structural Dynamicsrdquo
AK Chopra ldquoDynamics of Structures Theory and Application to Earthquake Engineeringrdquo Prantice Hall India
Mario Paz ldquo Structural Dynamics theory and Computationsrdquo CBS Publishers
Roy L Craig ldquo Structural dynamics Introduction to Computational methodsrdquo John Wiley
Meiroritch ldquoFundamentals of variablerdquo Mc Graw Hall
Jaikrashna ldquo Element of earthquake enggrdquo South asia publishers pvt Ltd
Hurty and Rubinsion ldquoDynamics of structuresrdquo PHI
Subject Code Subject L T P D MM
CE6022 PLASTIC ANALYSIS OF METALLIC STRUCTURES (Design and Viva)
0 0 0 6
PLASTIC ANALYSIS OF METALLIC STRUCTURES (Design and Viva) Moment of resistance shape factor criteria of plastic analysis comparison of elastic and plastic analysis Moment-curvature relationships for beams Plastic hinges Redistribution of moments Analysis of indeterminate beams and frames for ultimate load by the statical method and mechanism methods Load interaction method Approximate method of finding ultimate load Uniqueness theorems Limit theorems-Upper and lower bound theorems Factors affecting the full plastic moments Influence of axial force and shear Estimation of deflections at ultimate load Local and letral buckling Design of connections Minimum weight design Shake down analysis
Limit state design of structures
References
6
Baker and Heyman ldquoPlastic design of framesrdquo volIampII
Subject Code Subject L T P D MM
CE6023 STRESS ANALYSIS 3 0 0 0
STRESS ANALYSIS Full field analysis by photoelasticity laser interferometry and moireacute techniques Method of brittle coating Use of micro-processors for stress analysis
References Dally ldquoExperimental stress analysisrdquo McGrawHill
Subject Code Subject L T P D MM
CE6021 MATERIAL SCIENCE AND TECHNOLOGY
3 0 0 0
MATERIAL SCIENCE AND TECHNOLOGY Material Technology Cements-properties Aggregates Admixtures Properties of fresh and hardened concrete Mixing compacting transporting and curing of concrete Non-destructive testing special types of concrete Temperature control in mass concrete Creep and Shrinkage phenomenon in concrete Mix design Behaviour of concrete combined stresses Tests in cement aggregates and concrete Material Science Structure of materials Bonding Phase equilibrium Mechanical properties Theories of failure for combined static creep and fatigue effects Brittle and ductile fracture Plastic deformations Structural imperfections and dislocations Strain hardening Electric and magnetic properties of materials Corrosion of materials and their prevention
References
Smith ldquoPrincipal of material science and enggrdquo
Nevilly ldquoconcrete technologyrdquo
ubject Code Subject L T P D MM
CE6031
DESIGN OF INDUSTRIAL STRUCTURE AND BRIDGE
0 0 0 6
DESIGN OF INDUSTRIAL STRUCTURE AND BRIDGE (Design and Viva)
(a) Design and analysis of multi storeyed framed structures (b) Design of liquid retaining structures
(c) Design and analysis of chimneys Design of Bridges IRC codal provisions strut and tie model Load path analysis
References
NKRaju Design of bridges Oxford amp IBH Publishing Co pvt ltd
DJVictor Essentials of bridge engineering Oxford amp IBH Publishing Co pvt ltd
7
Indian Road Congress Codes No56182124 Jamnagar House Shah Jahan Road New Delhi
SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959
OP Jain ampJaikrishna ldquoPlain and reinforced concreterdquo Nemchandamp brothers
Subject Code Subject L T P D MM
CE6032
Design of tall buildings 3 0 0 0
Design of tall buildings
1 Design Criteria
Design philosophy loading sequential loading materials- high performance concrete- fiber reinforced concrete- light weight concrete- design mixes
2 Loading and Movement
Gravity loading dead and live load method of live load reduction impact gravity loading construction loads
Wind loading static and dynamic approach analytical and wind tunnel experimental method
Earthquake loading Equivalent lateral force model analysis combination of loading working stress design limit state design plastic design
3 Behaviour of various structural systems
Factor affecting growth height and structural form high rise behavior rigid frames braced frames infilled frames shear walls coupled shear walls walls-frames tubular- braced and hybrid mega system
4 Analysis and Design
Modeling for approximate analysis accurate analysis and reduction techniques analysis of building as total structural system considering overall integrity and major sub system interaction analysis for member forces drift and twist computerized general three dimensional analysis
Structural elements sectional shapes properties and resisting capacity design deflection cracking prestressing shear flow design for deferential movement creep and shrinkage effects temperature effect and fire
5 Stability of tall buildings
Overall buckling analysis of frames wall-frames approximate methods second order effects of gravity of loadingP-Delta analysis translational torsional instability out of plum effects stiffness of member in stability effect of foundation rotation
References
Bungale STaranath ldquoStructure Analysis amp Design of Tall Buildingsrdquo Mcgraw Hill Book Company Newyork 1999
Mark Fintel ldquoHandbook of concrete enggrdquo CBS
Council of tall building ldquoAdvances in tall buildingrdquo CBS
Subject Code Subject L T P D MM
CE6033 Seismic Design of Structures 3 0 0 0
8
Seismic Design of Structures
1 INTRODUCTION Elements of engineering Seismology - Theory of Vibration - Response Spectrum
2 HISTORICAL Indian Seismicity-Earthquake history - Behaviour of structures in the past Earthquakes
3 DESIGN CONCEPTS Seismic Design Concepts ndash Cyclic load Behavior of RC Steel amp Prestressed Concrete Element - Design Spectrum ndash Principles of Capacity Design
4 CODAL PROVISIONS Provisions of Seismic Code (IS 1893IS4326) ndash Building systems Frames Shear Walls Braced frames Combinations- Torsion
5 DESIGN amp DETAILING Performance of Regular Buildings 3D Computer Analysis of Building Systems (Theory Only) ndash Design amp Detailing of frames ndash Shear Walls ndashFrame walls
6 SPECIAL PROBLEMS amp CASE STUDIES Structural Configuration ndash Seismic performance- Irregular Buildings- Soil Performance-Modern Concepts ndash Base Isolation ndash Adoptive System ndash Case Studies
References
1 Course Notes ldquoDesign of Reinforced Concrete Building IIT Kanpur June 1999 2 Bungale STaranath ldquoStructure Analysis amp Design of Tall Buildingsrdquo Mcgraw Hill Book Company Newyork 1999 3 Mark Fintel ldquoHandbook of concrete enggrdquo CBS
Subject Code Subject L T P D MM
CE564 Photo Elasticity Laboratory 0 0 2 0
Photo Elasticity Laboratory
Stress analysis Two and Three Dimensional Photo-elasticity
Subject Code Subject L T P D MM
CE6512 PRESTRESSED CONCRETE DESIGN 3 0 0 3
PRESTRESSED CONCRETE DESIGN (Design and Viva) Flexural strength of prestressed concrete sections shear and torsional resistance Transfer of prestress in pretensioned members Bond and transmission length Anchorage zone stresses in pot-tensioned members
Design of pre-tensioned and post-tensioned beams Statically indeterminate structures design of continuous prestressed concrete beams and prestressed portal frames
Prestressed concrete piles and sleepers
Deflection of prestressed concrete members
References
NKRaju-Pre Stressed Concrete YGuyon-Pre Stressed Concrete
9
Mitchel amp Michael ldquoPrestressed concrete structurerdquo PHI
NRajagopalan ldquoPrestressed concreterdquoNarosa publishing house
JRLibby ldquoModern prestressed concreterdquo
Subject Code Subject L T P D MM
CE6513 SHELLS AND FOLDED PLATES
3 0 0 3
SHELLS AND FOLDED PLATES (Design and Viva) Shells Membrane theory North light shells Cylindrical shells Doubly curved shells Analysis and Design
References
SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959
OP Jain ampJaikrishna ldquoPlain and reinforced concreterdquo Nemchandamp brothers
Mark Fintel ldquoHandbook of concrete enggrdquo CBS
Subject Code Subject L T P D MM
CE6511 Design of Structures for Dynamic loads 0 0 0 6
Design of Structures for Dynamic loads
1Introduction
Factors affecting design against dynamic loads- behavior of concrete steel masonry and soil under impact and cyclic loads- recap of structural dynamics with reference to SDOF MDOF and continuum systems- ductility and its importance
2 Design against Earthquakes
Earthquake characterization ndash response spectra- seismic coefficient and response spectra method of estimating loads- response of framed braced frames and shear wall buildings- design as per BIS codes of practice- ductility based design
3 Design against blast and impact
Characteristic of internal and external blast- impact and impulse loads-pressure distribution on building above ground due to external blast- underground explosion- design of buildings for blast and impact as per BIS codes of practice
4 Design against wind
Characteristic of wind- basic and design wind speeds- effect of permeability of structure- pressure coefficient- aeroelastic and aerodynamic effect- design as per BIS code of practice including Gust factor approach-tall buildings stacks and chimneys
5 Special considerations
Energy absorption capacity- ductility of material and structure- detailing for ductility-passive and active control of vibrations- new and favourable materials
References
1 buildingrdquo John Willey and sons 1991
10
2 DowlingCHrdquoBlast vibration- monitoring and controlrdquo Prentice Hall Inc Englewood cliffs 1985 3 Kolousek Net al ldquowind effect on civil engineering structuresrdquo Elsevier 1984 4 Concrete structure under the impact Bela Goschy ldquodesign of buildings to withstand abnormal loadingrdquo
Butterworths1990 5 Paulay T and priestly MNJ ldquoA seismic design of reinforced concrete and masonry and impulsive
loadingSynthesis report CEB Lousanne getmany1988
Subject Code Subject L T P D MM
CE6521 DESIGN OF HYDRAULIC STRUCTURES 3 0 0 0
DESIGN OF HYDRAULIC STRUCTURES
1 Project planning of hydraulic structure site investigation and chose of type of hydraulic structures
2 Different types of dam their design stress analysis stress concentration around openings
3 Different types of spillway and energy dissipaters their design and analysis Model analysis of hydraulic structures
4 Design of weirs and barrages and analysis
Subject Code Subject L T P D MM
CE6524 PLANNING AND DESIGN OF ENVIRONMENTAL SERVICES
3 0 0 0
PLANNING AND DESIGN OF ENVIRONMENTAL SERVICES
Planning factors Ventilation and air conditioning plumbing Design of public bathing lighting housing with environmental perspectives
References
BCPunamia ldquoenvironmental engg Part-2rdquo
SKGarg ldquoenvironmental enggrdquo
Subject Code Subject L T P D MM
CE6522 GROUND WATER AND SEEPAGE 3 0 0 0
GROUND WATER AND SEEPAGE
Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic medium
Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel transformation and its application for ground water flow and seepage problems Numerical Techniques for solution of ground water flow
Multiple well system partially penetrating wells image wells mutual interference of wells
Storage and exploration of ground water Design Construction and Maintainence of wells Ground water recharge and run off Water quality budgeting simulation of ground water basin Application of remote sensing for ground water
Subject Code Subject L T P D MM
11
CE6523 INSTRUMENTATION 3 0 0 0
INSTRUMENTATION
Types of applications of measurement instrumentation Generalised configurations and functional descriptions of measuring instruments Motion measurement Pressure measurement Flow measurement Environmental engineering Instrumentations
Subject Code Subject L T P D MM
CE653 Structural Dynamics Laboratory 0 0 2 0
Structural Dynamics Laboratory
Model Testing Models of Frames under Static and Dynamic Loading Free and Forced Vibration using MTS Determination dynamic Modulus Damping etc and some more experiment heavy structural engg lab
Subject Code Subject L T P D MM
CE7011 GEOTECHNICAL EARTHQUAKE ENGINEERING
3 0 0 0
GEOTECHNICAL EARTHQUAKE ENGINEERING Introduction to engineering seismology seismic risks and hazards causes and strength of earthquakes social and economic
consequences theory of dynamic and seismic response the nature and attenuation of earthquake magnitude ground motion
determination of site characteristics local geology and soil condition determination of design earthquake response spectra and
accelerograms Site response to earthquake site investigation and soil test dynamic behaviour of soils liquefaction phenomena
analysis of pore pressure development laboratory and in-situ testing for liquefaction analysis and design of slopes embankments
seismic response of soil structure system shallow foundation pile foundation foundations and earth retaining structures for
seismic loading case histories mitigation techniques
Subject Code Subject L T P D MM
CE7012 FOUNDATION ENGINEERING
3 0 0 0
FOUNDATION ENGINEERING Structures subjected to vertical and lateral loads excavation vertical cut retaining walls shallow foundation flexible and rigid rafts highway pavements allowable bearing pressure geo-technical investigation interpretation from field tests pile and cassion group action of piles pier shafts in rock socket Foundations subjected to dynamic loads theory of vibrations natural frequency of a soil foundation system Elastic constant of soils pressure bulb concept permissible amplitude various considerations for machine foundation Strength and deformation characteristics of granular media under dynamic loads Liquefaction References
BM Das Advanced Foundation Engineering Brookes and Cole India
J Bowels Foundation analysis McGrawHill Publishers
Rao NSVK Vibration analysis and foundation dynamics AH Wheeler amp Co New Delhi India
Subject Code Subject L T P D MM
12
CE7013 SOIL STRUCTURE INTERACTION 3 0 0 0
Soil Structure Interaction
1 SOIL FOUNDATION INTERACTION Introduction to soil foundation interaction problems Soil Behaviour Foundation Behaviour Interface behaviour Scope of soil foundation interaction analysis Soil response models Winkler Elastic Continuum Two parameter elastic models Elastic plastic behaviour Time dependent behaviour
2 BEAM ON ELASTIC FOUNDATION ndash SOIL MODELS Infinite beam Two Parameters Isotropic elastic half space Analysis of beams of finite length Classification of finite beams in relation to their stiffness
3 PLATE ON ELASTIC MEDIUM Infinite Plate Winkler Two parameters Isotropic elastic medium Thin amp Thick plates Analysis of finite plates rectangular amp circular plates Numerical analysis of finite plates simple solutions
4 ELASTIC ANALYSIS OF PILE Elastic analysis of single pile Theoretical solution for settlement amp Load Distributions Analysis of Pile Group Interaction Analysis Load Distribution in groups with Rigid Cap
5 LATERALLY LOADED PILE Load Deflection Prediction for Laterally loaded piles Sub-grade reaction amp Elastic analysis Interaction analysis Pile raft system Solutions through influence charts
References 1 Selva durai APS Elastic analysis of Soil Foundation Interaction Elsevier 1979 2 Poulos HG amp Davis EH Pile Foundation Analysis amp Design John Wiley 1980 3 Scott RF Foundation Analysis Prentice Hall 1981 4 Structure Soil Interaction-State of Art Report Institution of Structure Engineers 1978 5 ACI 336 Suggested Analysis and Design Procedure for Combined Footings amp Mats American Concrete Institute Delhi
1988 6 SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959 7 SP Timoshenko Strength of material CBS Publisher 8 Bowles ldquoFoundation analysis and designrdquo McGrawHill
Subject Code Subject L T P D MM
CE7022 DISASTER RESISTANT STRUCTURES 3 0 0 0
Disaster Resistant Structures
1 BEHAVIOUR OF LIFE ndash LINE STRUCTURES Philosophy for design to resist earthquake Cyclone amp Flood-National amp International Codes of practice- By ndash Law of urban amp Semi-urban areas- Traditional amp Modern Structures
2 COMMUNITY STRUCTURES
Response of dams bridges buildings- Strengthening measures- Safety analysis and rating-Reliability assessment
3 REHABILITATION AND RETROFITTING
Testing and evaluation-Classification of structures for safety point of view- methods of strengthening for different disasters ndash qualification test
4 DETAILING OF STRUCTURES AND COMPONENTS
Use of modern materials amp their impact on disaster reduction- Use of modern analysis Design amp Construction techniques optimization for performance
5 DAMAGE ASSESSMENT OF STRUCTURES
Damage surveys- Maintenance and Modification to improve hazard resistance- Different types of Foundation amp its impact on safety- Ground improvement techniques
13
References
1 VMoskvin etall Concrete and Reinforced Concrete- Deterioration amp Protection- Mir Publishers-Moscow 1980 2 RTAllen and SCEdwards Repair of Concrete Structures Blakie and Sons UK 1987 3 3Proceedings IABSE 14th Congress ldquoCivilization through Civil Engineeringrdquo New Delhi May 1992 4 Raiker RNLearning from failure deficiencies in Design Construction and Service R amp D Centre (SDCPL) Raiker
Bhawan Bombay 1987 5 IS13827IS13828IS13935 6 ISO23941382315686 Part I to IX
Subject Code Subject L T P D MM
CE7021 ADVANCED BUILDING CONSTRUCTION AND MANAGEMENT
3 0 0 0
ADVANCED BUILDING CONSTRUCTION AND MANAGEMENT New techniques and materials of building construction Building construction management techniques
References
1 LSShrinath ldquoCPM ampPERTrdquo 2 Software PRIMAVERA-2 or above 3 Peurifoy ldquoConstruction planning equipment and methodsrdquo
Subject Code Subject L T P D MM
CE7023 Soil Dynamics and Geotechnical Earthquake Engineering
3 0 0 0
Soil Dynamics and Geotechnical Earthquake Engineering
Seismology and Earthquakes seismic hazard Analysis Engineering Problems involving Soil Dynamics Wave propagation in elastic media General nature of Soil Behaviour under cyclic dynamic loading Field and laboratory tests for measurement of small strained and large strain dynamic properties of soils
Strong Ground Motion measurement characterization and estimation Amplification Theory and Ground Response Analysis Local Site Effects and Design Ground Motions
Liquefaction Evaluation of liquefaction hazards susceptibility
Study of Initiation of liquefaction Characterization of Liquefaction resistance based on lab and in-situ tests and Evaluation of Initiation of Liquefaction
Study of effects of liquefaction
Seismic Slope Stability Seismic Design of retaining walls Soil Improvement for remediation of Seismic Hazards
References
Steven L Kramer lsquoGeotechnical Earthquake Engineeringrdquo Pearson Education
14
Scheme for M Tech (Geotechnical Engineering)
Sem Gp Course Details Course Code
L T P Intern Marks
Extern Marks
Total Marks
Credits
Ist A Advanced Soil mechanics CE521 3 0 0 50 100 150 3 Rock Mechanics CE523 3 0 0 50 100 150 3 Geotechnical Exploration CE522 3 0 0 50 100 150 3 Geotechnical Egg Lab-I CE524 0 0 2 30 70 100 2
B Advanced Foundation Engineering CE571 3 0 0 50 100 150 3 Soil Dynamics and Machine Foundations
CE572 3 0 0 50 100 150 3
Geotechnical Egg Lab-II CE573 0 0 2 30 70 100 2 Self Study open area seminar-I CE574 0 0 2 50 00 50 1
21Hoursweek 1000 20 IInd C Application of Geotechnical Engg in
Water Resources amp GIS CE621 3 0 0 50 100 150 3
Elective I any one of the following 1 Computational Geotechnics 2 Plasticity amp fracture Mechanics in
Rock Structures 3 Theoretical Soil Mechanics
CE6221 CE6222 CE6223
3 0 0 50 100 150 3
Elective II any one of the following 1 Design of Hydraulic Structures 2 Geo-environmental Engineering 3 Groundwater and Seepage
CE6231 CE6232 CE6233
3 0 0 50 100 150 3
Geotechnical Engg Lab-III CE624 0 0 2 30 70 100 2 D Elective III any one of the following
1 Excavation Technology 2 Geotechnical Earthquake
Engineering 3 Theory of Elasticity and Plasticity
CE6711 CE6712 CE6713
3 0 0 50 100 150 3
Elective IV any one of the following 1 Ground Improvement Techniques 2 Geosynthetics 3 Slope Stability Analysis
CE6721 CE6722 CE6723
3 0 0 50 100 150 3
Geotechnical Engg Lab IV CE673 0 0 2 30 70 100 2 Minor Project I CE674 0 0 2 50 00 50 1
21Hoursweek 1000 20 IIIrd E Elective V any one of the following
1 Critical State Soil Mechanics 2 Design of Sub-structures 3 Soil Structure Interaction
CE7211 CE7212 CE7213
3 0 0 50 100 150 3
Elective VI any one of the following 1 Earth Pressure amp Earth Retaining
Structures 2 Offshore Geotechnical
Engineeging 3 Unsaturated Soil Mechanics
CE7221 CE7222 CE7223
3 0 0 50 100 150 3
Self Study open area seminar II CE723 0 0 2 50 00 50 1 Minor Project II CE724 0 0 4 00 200 200 4 Major Project part I CE725 0 0 2 200 00 200 4
18Hoursweek 750 15 IVth F Major Project Part II CE821 3 0 0 00 750 750 15 6Hrsw
k 750 15
Grand Total 3500 70
15
Advanced Soil Mechanics
Paper Code L T P Cr
CE 521 3 0 0 3
Clay minerology clay-water electrolyte system soil structure and fabric Effective stress hydraulic conductivity seepage Special
soils collapsible amp sensitive clays loessic bouldary and expansive soils Consolidation one-dimensional and generalised
consolidation theories primary and secondary consolidation sand drains consolidation settlements Shear behaviour of soils pore
pressure parameters UU CUampCD tests stress path method for settlement analysis Total amp effective stress-path water content
contours stress history Anisotrppy of strength Thixotropy Creep Determination of in situ undrained shear strength stress-strain
characteristics of soilsDetermination of modulus values Critical state model
20 Rock Mechanics
Paper Code L T P Cr
CE523 3 0 0 3
Introduction problems of rock mechanics classifications of rock masses rock exploration ndash rock coring geophysical methods
laboratory testing of rocks fraction in rocks elasticity amp strength of rocks strength amp failure of rocks Griffithrsquos theory
Coulombrsquos theory in-situ tests on rock mass deformation characteristics instrumentation and measurement of deformation of
rocks permeability Mechanical thermal and electrical properties of rock mass openings in rock mass and stresses around
openings slope stability pressure tunnels development of plastic zone rock support needed to avoid plastic deformation lined
and unlined tunnels support pressure and slip of the joint underground excavation and subsidence foundation on rocks bearing
capacity of intact and jointed rocks rock slopes rock bolt anchors amp grouting underground openings pillars tunnels methods of
construction problems associated with tunnels tunnelling in various subsoil conditions and rocks
30 Geotechnical Exploration
Paper Code L T P Cr
CE 522 3 0 0 3
Planning of geotechnical exploration methods of boring Boring in soils and rocks methods of stabilizing the bore holes
Sampling techniques Sampling disturbances storage labeling and transportation of samples sampler design influence on
properties field tests standard penetration plate load static and dynamic cone penetration field vane shear and pressuremeter
tests electrical resistivity and seismic refraction tests location of ground water table processing of soil exploration data and its
interpretation
40 Geotechnical Engineering Lab I
Paper Code L T P Cr
CE 524 0 0 2 2
This Laboratory is based on the syllabus of CE 541 CE 542 CE 543
16
50 Advanced Foundation Engineering
Paper Code L T P Cr
CE 571 3 0 0 3
Shallow foundations subjected to static eccentric and inclined loads bearing capacity analysis settlement amp allowable bearing
capacity of shallow foundation uplift capacity of shallow foundation raft foundations pile foundations-design in different soil
conditions load distribution between vertical and battered piles moment on pile foundations group effect on piles raft on piles
piers and pier shafts caisson settlement analysis of pile groups amp shafts analysis amp design of well foundation foundation on
reinforced soil
60 Soil Dynamics amp Machine Foundation
Paper Code L T P Cr
CE 572 3 0 0 3
Introduction fundamentals of vibrations vibration of elementary systems-mass spring
dashpot systems various degrees of freedom dynamic properties of geo-materials propagation of wave in granular media
laboratory and field tests for evaluation of dynamic soil properties analysis and design of foundations for hammers reciprocating
engines and turbo generators dynamic stiffness of single pile and pile groups vibration isolation and damping theories for
vibration of foundations on elastic media design procedures for foundations with dynamic load and construction features elastic
homogeneous half space solutions lumped parameter solutions large deformation problems liquefaction of soils amp cyclic
mobility
70 Geotechnical Engineering Lab II
Paper Code L T P Cr
CE 573 2 2
This Laboratory is based on the syllabus of CE 541 542 543 545 546
8 Application of Geotechnical Engg in Water Resources amp GIS
Paper Code L T P Cr
CE 621 3 -- -- 3
Selection of sites for different water resources projects Geotechnical investigations Classification of dams Causes of failure of
earth dams relative advantages and disadvantages of earth dams over gravity dam Preliminary section of earth dams Typical
section of earth dams Checking the stability of earth dams Slope stability analysis Stability of foundation of earth dams against
shear Design consideration of earth dam in seismic regions Rockfill dam impervious membrane type rockfill dam design
consideration of rockfill dam Hydroelectric power classifications and investigations Features and characteristics of hydropower
generation and Principal components of a hydropower station Design of different components like Intakes Water conductor
system Tunnels Surge tanks Penstocks Anchor blocks and their management at site
17
Introduction to GIS and remote sensing cartographic data model digital data model data source data capture and data analysis
role of remote sensing and GIS in flood disaster studies Landslides and Earthquake Various GIS packages and their salient
features
90Elective I Opt any one of the following
10 Theoretical Soil Mechanics
20 Computational Geotechnics
30 Plasticity amp Fracture Mechanics in Rock Structures
100Elective II Opt any one of the following
40 Geo-environmental Engineering
50 Ground water amp Seepage
60 Design of Hydraulic structures
110 Geotechnical Engineering Lab III
Paper Code L T P Cr
CE 624 2 2
This Laboratory is based on the syllabus of courses mentioned above
120Elective III Opt any one of the following
70 Goetechnical Earth quake Engineering
80 Theory of Elasticity and Plasticity
90 Excavation Technology
130Elective IV Opt any one of the following
100Ground Improvement Techniques
110 Geosynthetics
120 Slope Stability Analysis
140 Geotechnical Engineering Lab IV
Paper Code L T P Cr
CE 673 2 2
This Laboratory is based on the syllabus of courses mentioned above
150Elective V Opt any one of the following
130 Critical State Soil Mechanics
140 Design of Sub Structures
18
150 Soil Structure Interaction
160Elective VI Opt any one of the following
160 Unsaturated Soil Mechanics
170Flow Through Porous Media
180 Earth Pressure amp Earth Retaining Structures
SYLLABUS OF ELECTIVE COURSES
10 Theoretical Soil Mechanics
Paper Code L T P Cr
CE 6223 3
Stresses and strains elastic equilibrium analysis for plane strain and three dimensional cases Effective stresses analysis of
deformation and strain states of stress and strain consitutive relationsequilibrium and compatibilitygeneral theorems drained
and undrained loading state boundary surface plastic flow yield and hardeningfailure theorems for soils failure and plastic flow
at critical state associative and non-associative flow residual strength anisotropic compressions ideal elastic behaviour ndash two
and three dimensional systems theorems of plastic collapse and their application to soil-structure interaction elastoplastic theory
of soils rheological models nonlinear viscoelasticity problems and solutions
20 Computational Geotechnics
Paper Code L T P Cr
CE 6221 3
Introduction to numerical modeling in Geotechnical Engineering basic concepts stress deformation analysis analysis of
foundations dams underground structures and earth retaining structures Finite difference method Finite element method
Boundary element method Discrete element method Constitutive modeling use of finite element finite difference and discrete
element computer codes for solving geotechnical engineering problems Use of some of the appropriate software package like
UDEC FLAC PLAXIS etc
3 Plasticity amp Fracture Mechanics in Rock Structures
Paper Code L T P Cr
CE 6222 3
Theory of plasticity Three dimensional stress analysis stress invariants octahedral stresses Large deformationsfinite strains -
Euler amp Langragian approaches Greenrsquos amp Cauchyrsquos strain tensors Yield criteria Von Mises Tresca Mohr-Coulomb Drucker-
Prager Modified Mohr-Coloumb Hoek amp Brown yield criteria Isotropic and Kinematic hardening softening normality principle
plastic flow rule plastic potential Druckerrsquos postulates and Prandtlrsquos conditions for stability of plastically deforming bodies
Plastic Stress-Strain relations Stress path dependent behaviour Prandtl-Rauss equations Levy-Mises relations generalised
19
elasto-plastic stress-strain realtionshardening modulus Applications to problems of tunnels etc Crack phenomenon and
mechanics of brittle fracture propagation effects of crack on elasticproperties Energy theories of failure elementary theories of
crack propagation cracks in elasto-plastic media Constitutive equations for rocks ndash Class I and Class-II materials Servo
controlled testing and post failure behaviour under uniaxial and triaxial stress conditions in tension Compression and shear size
effects representative size of specimen Continum characterization of jointed rock mass Weibullrsquos thoery in tension
compression and bending for strength constitutive equations for discontinuities ndash Joint stiffnesses and shear strength Ladanyirsquos
constitutive equations Stick Slip phenomenon Application of fracture mechanics to underground opening rock stabbing bursting
and hydraulic fracturing
40 Geo Environmental Engineering
Paper Code L T P Cr
CE 6232 3
Introduction Sources of subsurface contamination Mechanisms of Soil contamination Physical-chemical and biological
interactions in soils Effect of contamination on geotechnical properties Waste disposal on land Types of landfills Siting criteria
waste containment principles Types of barrier materials Planning and design aspects relating to waste disposal in landfills in ash
ponds and tailing ponds Environmental monitoring around landfills Detection control and remediation of subsurface
contamination Various types of barrier systems Reclamation of contaminated sites Case Studies
50Ground Water and Seepage
Paper Code L T P Cr
CE 6233 3
Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic
medium Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel transformation and its
application for ground water flow and seepage problems Multiple well system partially penetrating wells image wells mutual
interference of wells Storage and exploration of ground water design construction and maintenance of wells ground water
recharge and run off water quality budgeting simulation of ground water basin application of remote sensing for ground water
60 Design of Hydraulic Structures
Paper Code L T P Cr
CE 6231 3
Project planning site investigations choice of type of dams cost-benefit studies Non-overflow dams gravity arch and buttress
type rock-fill and earthen dams their design stress analysis stress concentration around openings Different types of spillways
and energy dissipaters their design preparation and protection of foundation for dams model analysis of hydraulic structures
instrumentation in dams temperature control in concrete dams
70 Geotechnical Earthquake Engineering
Paper Code L T P Cr
20
CE 6712 3
Introduction to engineering seismology seismic risks and hazards causes and strength of earthquakes social and economic
consequences theory of dynamic and seismic response the nature and attenuation of earthquake magnitude ground motion
determination of site characteristics local geology and soil condition determination of design earthquake response spectra and
accelerograms Site response to earthquake site investigation and soil test dynamic behaviour of soils liquefaction phenomena
analysis of pore pressure development laboratory and in-situ testing for liquefaction analysis and design of slopes embankments
seismic response of soil structure system shallow foundation pile foundation foundations and earth retaining structures for
seismic loading case histories mitigation techniques
80 Theory of Elasticity and Plasticity
Paper Code L T P Cr
CE 6713 3 - -
Theory of Elasticity Stress tensor equations of equilibrium Kinematic relationships and equations of compatibility Generalized
Hookersquos Law Boundary conditions Plane stress plane strain Airyrsquos stress function Saint Venantrsquos principle Problems in
rectangular and polar co-ordinates inverse and semi-inverse methods torsion of Prismatic bars members analogy typical
applications Theory of plasticity hydro-static and deviatoric components of stress tensor invariant of stress tensors Tress-Saint
Venant and Honkey-Von Misses yield conditions octahedral stresses Analysis of Bending of bars of narrow rectangular
cross section-formation of Plastic hinge Torsion of prismatic bars-sand-heap analogy Thick spherical shell-bursting pressure
Thick cylindrical tube
90Excavation Technology
Paper Code L T P Cr
CE 6711 3
Construction Planning amp scheduling Importance of planning pre-planning analysis Network planning including CPM amp PERT
techniques Contract management Contractual Risks amp Risk management Excavation in soils Tractors Dozers Bull-dozers
Wheel Loaders Shovels Draglines Buckets Clampshells Scrapers Hydraulic Excavators Excations in Rocks manual
excavation tools and techniques Drilling and blasting versus Ripping Excavations of Dam Foundations Controlled drilling and
blasting Selection and matching of loading and hauling equipment Excavations of tunnels amp caverns Type of cuts and drilling
patterns Methods of Tunnel driving Excavation cycles Full face heading heading and benching Ring drilling method
Forepoling Side drift method Presplitting and smooth blasting Excavation in different ground conditions mixed face tunneling
Machine Tunneling Shield tunneling Types of TBMs new TBMs New Austrian Tunneling Method(NATM) Norweign
Tunneling Method (NTM) TBMs versus drilling and blasting TBM in different ground conditions Limitations of machine
tunneling Excavations of Shafts and Caverns Excavation with limit raiser climber Shaft boring lining segments for shield driven
tunnels Differnet stages in excavation of caverns Ventilation in Long Tunnels
100 Ground Improvement Technique
Paper Code L T P Cr
CE 6721 3
21
Ground improvement principles of ground improvement mechanical modificationproperties of compacted soil compaction
control tests hydraulic modification dewatering systems filtration drainage and seepage control with geosynthetics preloading
and vertical drains electro kinetic dewatering chemical modification modification by admixtures stabilization using industrial
wastes grouting modification by inclusion and confinement soil reinforcement flexible geosynthetic sheet reinforcement
anchorage reinforcement techniques bearing capacity improvement slope stability erosion control retaining walls and
pavements Soil stabilization shallow stabilization with additives lime flyash cement and other chemicals and bitumen deep
stabilization sand column stone column sand drains prefabricated drains electro-osmosis lime column soil-lime column
grouting permeation compaction and jet vibro-floatation dynamic compaction thermal freezing dewatering systems
110 Geosynthetics
Paper Code L T P Cr
CE 6722 3
Geosynthetics types and functions materials and manufacturing processes testing and evaluations principles of soil
reinforcement design and construction of geosynthetic reinforced soil retaining structures walls and slopes Geosynthetics in
pavements geosynthetics in roads and railways separations drainage and filtration in road pavements and railway tracks design
and construction relevant guidelines Geosynthetics in pollution control liners for ponds and canals covers and liners for
landfills material aspects and stability considerations
120 Slope Stability Analysis
Paper Code L T P Cr
CE 6723 3
Introduction Natural and man made slopes types of slope movements amp land slides nature of soil amp rock Progressive failure of
slopes Limit Equlibrium Methods Infinite and finite height slopes Planar failure surface Slip surface of arbitrary shape Natural
slope analysis considering initial stresses Sewdish method Bishoprsquos simplified methodother methodsstability chart Various
conditions of analysis factor of safety codal provisions Some special aspects of slope analysisie Earthquakes Creep
Anisotropy Probabilistic approach in slope analysis Centrifuge Model testingReinforced slopesembankment on soft soils
130 Critical State Soil Mechanics
Paper Code L T P Cr
CE 7211 3 - -
Review of stress and effective stress analysis of deformation and strain ideal elastic behavior elastoplastic behavior of soils
stress path and invariants constitutive relations drained and undrained loading isotropic compressions elastic wall state
boundary surface associative and non-associative flow yield and hardening critical state line amp Roscoe surface plastic collapse
residual strength behavior of oc clays for Hvorslev surface critical state for sand effect of dilation applications
140 Design of Sub-Structures
Paper Code L T P Cr
CE 7212 3
22
Introduction Substructure ndash Definition and purpose role of foundation engineern Basic Soil input parameters for foundation
design Foundation Design General principles Types of foundations selection of type of foundation Basic requirements
Computation of loads Limit State Design Basic principles Shallow Foundations Types and their selection Conventional
method of design Beams on elastic foundation and Finite difference method of analysis Structural design of footings and rafts
Foundations subjected to eccentric-inclined loads Footing in seismic zones Pile Foundations Type construction techniques
Proportioning of pile foundations loadsforces considered for structural design Structural design of pile foundation for a
multistoreyed buildings and other important structures Pile foundations subjected to dynamic loads Bridge Substructures _
Forces on bridge Foundation (IRC amp IS specifications) Design of piers Abutments amp wing Walls Well Foundation Components
Stability analysis Design of various components Materials for construction Sinking of well Placing of Curb Dredging and
Jetting marine Substructure Types Breakwaters Wharves Sea Walls Design and Construction Methods Foundations of
transmission line towers forces on tower foundation General design criteria Choice amp type of foundation Design Procedure
150 Soil-Structure Interaction
Paper Code L T P Cr
CE 7213 3
General soil-structure interaction problems contact pressures and soil-structure interaction for shallow foundations concept of
sub grade modulus effectsparameters influencing subgrade modulus analysis of foundations of finite rigidity beams on elastic
foundation concept introduction to the solution of beam problems Curved failure surfaces their utility and analyticalgraphical
predictions from Mohr-Coulomb envelope and circle of stresses earth pressure computations by friction circle method earth
pressure distribution on walls with limitedrestrained deformations Dubravorsquos analysis earth pressures on sheet piles braced
excavations design of supporting system of excavations arching in soils elastic and plastic analysis of stress distribution on
yielding bases Modern concept of analysis of piles and pile groups axially laterally loaded piles and groups interaction analysis
Reese and Matlockrsquos tunnelling solution elastic continuum and elasto-plastic analysis of piles and pile groups Hrennikoffrsquos
analysis ultimate lateral resistance of piles by various approaches non-linear load-deflection response uplift capacity of piles and
anchors
160 Unsaturated Soil Mechanics
Paper Code L T P Cr
CE 7223 3
Identification and classification of expansive and collapsing soils effective stress concepts matric and osmotic suction collapse
heave and strength characteristics of unsaturated soils flow through unsaturated soils laboratory evaluation of swell pressure and
swell potentialtests to evaluate collapse potential measurements of soil suction
170Offshore Geotechnical Engineeging
Paper Code L T P Cr
CE 7222 3
Submarine soilsoriginnature and distributionTerriginic and pelagicsubmarine soils of India Engineering behaviour of
submarine soilsunder consolidated soilscalcareous soilscemented soilscorals
23
Offshore site investigations sampling and sampling disturbanceinsitu testingwireline technologyoffshore pile foundations for
jacket type structuresfoundations of gravity structures
Foundations for jack-up rigsanchors and break out forcesanchor systems for floating structuresstability of submarine
slopesInstallation and stability of submarine pipelines
180 Earth Pressure amp Earth Retaining Structure
Paper Code L T P Cr
CE 7221 3
Earth pressure theories Rankines theory Coulombs theory graphical techniques amp analytical methods rigid retaining structures
types empirical methods stability analysis Flexible retaining structures types material cantilever sheet piles anchored
bulkheads ndash free earth method fixed earth method moment reduction factors anchorage Braced excavation types construction
methods pressure distribution in sands and clays stability - bottom heave seepage ground deformation Reinforced soil walls
elements construction methods external stability internal stability Arching action underground structures in soils pipes
conduits trenchless technology tunnelling techniques - cut-and-cover method shield tunnelling Stability of slopes analysis of
earth amp rock fill dam
Recommended Books-
1 The Mechanics of Soils JH Atkinson amp PL Brandsy (1982) 2 Critical State Soil Mechanics AN Schofield amp CP Wroth (1968) 3 Introduction to Rock Mechanics RE Goodman (1989) 4 Engineering in Rocks T Ramamurthy (2007) 5 Shallow Foundation BM Das (1999) 6 Foundation Analysis amp Design JE Bowles (1988) 7 Foundation Engineering G Leonards (1962) 8 Basic amp Applied Soil Mechanics G Ranjan amp ASR Rao (2006) 9 Soil Dynamics S Saran (1999) 10 Geotechnical Earthquake Engineering SL Kramer (2003) 11 Geotechnical Modelling DM Wood (2004) 12 Analysis amp Design of Substructures S Saran (1996) 13 Geotechnical Practice for Waste Disposal DE Danial (1993) 14 Ground Water DK Todd (1959) 15 Designing with Geosynthetics RM Koerner (1997) 16 Ground Water amp Seepage ME Harr (1962) 17 Ground Water amp Seepage DK Todd (1959) 18 Engineering Hydrology SS Butler (1959) 19 Ground Water its development uses and conservation EW Bennisen (1972) 20 Theory of Elasticity amp Plasticity SP Timoshenko amp JN Goodier (1982) 21 Soil Mechanics in the light of Critical State Theories JAR Ortigao (1995) 22 Design of Small Dams USBR Manual (1965) 23 Design and Construction of Dams Edward Wegwann (1978) 24 Earth and Rock Dams Sheard L James 25 Properties of Concrete AM Neville (2007) 26 The Chemistry of Cement and Concrete FM Lea (1970) 27 Soil Mechanics Principle and Practice GE Barnes (2000) 28 Advanced Soil Mechanics BM Das (1997) 29 Soil Mechanics for Unsaturated Soils DG Fredlund and H Rahardjo (1993) 30 Soil Mechanics TW Lambe and RV Whitman (1987) 31 Fundamentals of Soil Behaviour James K Mitchell (1993) 32 Principles of Soil Mechanics RF Scott (1963) Foundation Analysis and Design JE Bowles (1996) 34 Foundation Design Principles and Practices Donald P Coduto (2001)
24
35 Design Aids in Soil Mechanics and Foundation Engineering Shenbaga R Kaniraj (1988) 36 Pile Foundation Analysis and Design HG Poulus and EH Davis (1980) 37 Earth and Earth-Rock Dams JL Sherard RJ Woodward SF Giziensky and WA Clevenger (1963) 38 Soil Mechanics in Engineering Practice K Terzaghi RB Peck and G Mesri (1996) 39 Foundation Design and Construction MJ Tomlinson (1996) 40 Engineering Treatment of Soils FC Bell (1993) 41 Earth Reinforcement and Soil Structures JFP Colin (1996) 42 Foundation Engineering Handbook HY Fang (1991) 43 Engineering Principles of Ground Modification MR Hausmann (1990) 44 Ground Improvement MP Moseley (1993) 45 Ground Control and Improvement PP Xanthakos LW Abramson and DA Bruce (1994) 46 Design Construction and Monitoring of Landfills A Bagchi (1994) 47 Geoenvironmental Engineering LN Reddi and HI Inyang (2000) 48 Environmental Geotechnics R Sarsby (2000) 49 Planning Design and Analysis of Tailings Dams SG Vick (1970) 50 Earthquakes Bruce A Bolt (1999) 51 Exploration Geophysics of the Shallow Subsurface Robert H Burger (1992) 52 Principles of Soil Dynamics BM Das (1993) 53 Geotechnical Earthquake Engineering Handbook RW Day (2002) 54 Construction Vibrations CH Dowding (2000) 55 Soil Behaviour in Earthquake Geotechnics Kenji Ishihara (1996) 56 Geotechnical Earthquake Engineering SL Krammer (1996) 57 Cyclic Loading of Soils from Theory to Design MP OrsquoReilly and SF Brown (1991) 58 Foundations for Machines Analysis and Design S Prakash and V K Puri (1988) 59 Dynamic Soil Structure Interaction John P Wolf (1985) 60 Rock Engineering JA Franklin and MB Dusseaut (1989) 61 Introductory Rock Mechanics RF Goodman (1980) 62 Foundation of Theoretical Soil Mechanics ME Harr (1966) 63 Fundamentals of Rock Mechanics JC Jaeger and NGW Cook (1969) 64 Elastic Solutions for Soils and Rock Mechanics HG Poulos and EH Davis (1974) 65 Rock Mechanics in Engineering Practice KG Stagg and OC Zienkiewics 66 Numerical Methods in Geotechnical Engineering DesaiCS and Christian 67 Finite Element Procedures in Engineering Analysis BatheKJ 68 Soil Behaviour and Critical State Soil Mechanics Wood DM
25
Scheme for M Tech (Environmental Engineering)
Sem Gp Course Details Course Code
L T P Intern Marks
Extern Marks
Total Marks
Credits
Ist A Advanced Mathematics and Statistics CE-511 3 0 0 50 100 150 3 Environmental Chemistry and Microbiology
CE512 3 0 0 50 100 150 3
Water Pollution CE513 3 0 0 50 100 150 3 Microbiology Lab CE514 0 0 2 30 70 100 2
B Air Pollution amp Control CE561 3 0 0 50 100 150 3 Water Engineering Design CE562 3 0 0 50 100 150 3 Water Engineering Laboratory CE563 0 0 2 30 70 100 2 Self Study open area seminar-I CE564 0 0 2 50 00 50 1
21Hoursweek 1000 20 IInd C Wastewater Treatment Design CE611 3 0 0 50 100 150 3
Elective I any one of the following 1 Groundwater and Seepage 2 Instrumentation
CE6121 CE6122
3 0 0 50 100 150 3
Elective II any one of the following 1 Design of Hydraulic Structures 2 Industrial Wastewater Treatment
CE6131 CE6132
3 0 0 50 100 150 3
Air Pollution Laboratory CE614 0 0 2 30 70 100 2 D Elective III any one of the following
1 Global Warming and Climate Change
2 Planning and Design of Environmental Services
CE6611 CE6612
3 0 0 50 100 150 3
Elective IV any one of the following 1 Environmental Planning and
Management 2 Solid Waste Management
CE6621 CE6622
3 0 0 50 100 150 3
Solid Waste amp Industrial Wastewater Analysis Lab
CE663 0 0 2 30 70 100 2
Minor Project I CE664 0 0 2 50 00 50 1 21Hoursweek 1000 20 IIIrd E Elective V any one of the following
1 Environmental Impact Assessment and Audit
2 Remote Sensing and GIS in Environmental Engineering
CE7111 CE7112
3 0 0 50 100 150 3
Elective VI any one of the following 1 Air Quality Modeling 2 Hazardous Waste Management 3 Occupational Safety and Health
CE7121 CE7122 CE7123
3 0 0 50 100 150 3
Self Study open area seminar II CE713 0 0 2 50 00 50 1 Minor Project II CE714 0 0 4 00 200 200 4 Major Project part I CE715 0 0 2 200 00 200 4
18Hoursweek 750 15 IVth F Major Project Part II CE811 3 0 0 00 750 750 15 6Hrsw
k 750 15
Grand Total 3500 70
26
MTech(Civil) Environmental Engineering
GROUP lsquoArsquo SUBJECTS
CE-511 Advanced Mathematics and Statistics
Numerical Methods - Partial differential equations Newton-Raphson method Finite difference finite element method of characteristics different methods Successive over relaxation methods Optimization ndash classification and importance in Environmental Studies Single and multivariable optimization without and with constraints Linear Programming ndash different methods linear approximation of non-linear optimization Statistics - Significance Tests Frequency Distribution Characteristics of Distributions Method of Least Squares and Regression Multiple Regression Probability ndash Concepts Methods Binomial Poisson and Normal distribution Risk and uncertainty analysis
CE-512 Environmental Chemistry and Microbiology
Aquatic Chemistry Hydrological cycle structure of water molecule water as solvent principles of equilibrium chemistry pH oxidation-reduction and the application of principles of chemistry for solving Environmental Engg problems
Chemistry of pollution due to detergents pesticides polymers trace organics metals mining petroleum and radioactive compounds
Chemistry of the atmosphere Global environmental problems- chemistry of CFC ozone depletion green house effect etc
Environmental Microbiology basic principles of microbial transformation of organic matter Microbial biochemistry biodegradation acclimatization of wastes and microbial inhibition mechanisms
Structure and function of cell constituents pure and mixed cultures aerobic and anaerobic metabolism microbial growth and dynamics microbial taxonomy classification amp morphological aspects of protozoa bacteria fungi algae and other higher aquatic life forms
Bioassay tests for toxicity evaluation pathogens and indicator organisms
Environmental Biotechnology Role of microbes in water and wastewater Engg Microbiology applied to bio scrubbers and bio filters bioremediation
CE-513 Water Pollution
Water quality Detection and measurement of Water Pollution Stream surveillance Standards Criteria Objective and goal of water quality for different uses Water quality management
Modeling approaches to water quality - classification ndash Mathematical Models for water quality
DO Models for Streams Models for microorganisms decay Eutrophication models - simplified nutrient loading models for rivers and lakes Management of Water Pollution Disposal of wastewater
CE-514 Microbiology Lab
27
Microscopic Examination of Microorganisms Preparation of bacterial smear - staining - Hanging drop technique - plate count test MPN tests and MFT Tests
GROUP lsquoBrsquo SUBJECTS
CE-562 Water Engineering Design
Introduction ndash Sources of water necessity of treatment Critical Water quality parameters water quality guidelines and standards for various water uses
Unit operations ndash principles and design of aeration systems ndash two film theory water in air system air in water system Intake structures ndash Different types design criteria
Principles of sedimentation ndash types of settling and settling equations design criteria and design of settling tanks Principle of Coagulation and Flocculation ndash types of coagulants coagulant aids coagulation theory optimum dose of coagulant design criteria and numerical examples
Filtration - theory of granular media filtration Classification of filters dual and multimedia filtration Adsorption Process Disinfection Water Softening Fluoridation and defluoridation ndash Principles and design Ion Exchange-processes Application Membrane Processes Reverse osmosis Ultrafiltration Electrodyalisis corrosion and corrosion control distribution design of various components of the distribution system
Design of the units of Water Treatment Plant
CE-561 Air Pollution and Control
Definition air pollutants air pollution measurement ambient and at source Effects of air pollution Standards Meteorology Dispersion of air pollutants Air pollution control equipmentsmdashsettling chambers Inertial devices electrostatic precipitator scrubbers fitters adsorption devices combustion devices condensation devices
CE-563 Water Engineering Laboratory
Physical and chemical characteristics of water pH EC Turbidity alkalinity acidity hardness sulphates fluorides nitrates Total solids volatile solids fixed solids Residual chlorine analysis optimum coagulant dose BOD COD Determination of heavy metals in water Total organic carbon CHNS analysis
CE-564 Self Study Open Area Seminar- I
Self Study
GROUP lsquoCrsquo SUBJECTS
CE-611 Wastewater Treatment Design
Treatment objectives Methods and design fundamentals of process analysis Physical unit operations screening flow equalization mixing Physico-chemical Treatment Systems flocculation sedimentation floatation filtration chemical unit processes Biological unit processes Bio kinetics treatment and disposal of sludge Emerging technologies for wastewater treatment and their design
CE-6121 Groundwater and Seepage
28
Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic medium
Steady and unsteady flow through confined and non-confined aquifers Schwartz Christoffel transformation and its application for ground water and seepage problems
Multiple well system partially penetrating wells image wells mutual interference of wells
Storage and exploration of ground water design construction and maintenance of wells Ground water recharge and run off Water quality budgeting simulation of ground water basin Application of remote sensing for ground water
CE-6121 Instrumentation
Types of application of measurement instrumentation Generalized configuration and functional description of measu4ring instruments Motion measurement Pressure measurement Flow measurement Environmental Engg Instrumentation
CE-6131 Design of Hydraulic Structures
Project planning site investigations choice of type of dams Cost benefit studies
Non-overflow dams Gravity Arch and buttress type Rock fill and earthen dams their design stress analysis stress concentration around openings
Different types of spillways and energy dissipaters their design Preparation and protection of foundation for dams Model analysis of Hydraulic structures Instrumentation in dams Temperature control in concrete dams
CE-6132 Industrial Waste Water Treatment
Theories of waste water treatments combined treatment of raw industrial waste with domestic sewage Discharge of completely treated waste to Municipal Sewer discharge of raw waste to stream characteristics and treatment of wastes from the apparel industry Food processing industries Material industries Chemical industries Energy industries
CE-614 Air Pollution Laboratory
Experiments using High volume sampler personnel sampler RSPM sampler stack monitoring kit
GROUP lsquoDrsquo SUBJECTS
CE-6611 Global Warming and Climate Change
Energy Issues and Climate Change Alternate Energy Sources Green-House Effect as a Natural Phenomenon Green House Gases GHGs) and their Emission Sources
Quantification of CO2 Emission Global Warming Potential (GWP) of GHGs Modeling Climate change Ozone layer depletion and its control Impacts of climate change ndash Global and India Temperature Rise Sea Level rise Coastal Erosion and landslides Coastal Flooding Wetlands and Estuaries loss
Kyoto Protocol ndash Importance Significance and its role in Climate Change Carbon Trading - Mechanisms
Various Models (European Indian) Global and Indian Scenario Cleaner Development Mechanisms ndash Various Projects related to CO2 Emission Reduction Alternatives of Carbon Sequestration ndash Conventional and non-conventional techniques
29
Role of Countries and Citizens in Containing Global Warming
References
1 Packe and Smith Climate Change
2 Gilbest
CE-6611 Planning and Design of Environmental Services
Planning factors Ventilation and Air conditioning Plumbing Design of Public Bathing Places Lighting Housing with Environmental Perspective
CE-6621 Environmental Planning and Management
Environment and Sustainable Development - carrying capacity relationship with quality of life carrying capacity and resource utilization Engineering Methodology in Planning and its Limitations ndash carrying capacity based short and long term regional planning Environmental Protection - Economic development and social welfare consideration in socio economic developmental policies and planning Total cost of development and environmental protection cost Case studies on Regional carrying capacity Engineering Economics ndash Value Engineering Time Value of Money Cash Flows Budgeting and Accounting Environmental Economics Introduction economic tools for evaluation Green GDP Cleaner development mechanisms and their applications Environmental Audit ndash methods procedure reporting and case studies Total Quality Management in environmental management and protection ndash ISO 9000 14000 and 18000 series of standards
CE-6622 Solid Waste Management
Sources of solid waste types of solid waste methods of disposal of solid waste recycle and reuse problems in the management under Indian conditions
Mechanical Transformation of solid wastes screening size reduction various devices for size reduction objectives
Thermal Transformation of solid wastes pyrolysis incineration gasification
Ultimate disposal of solid wastes Landfills problems location of landfills leachate composition management of leachate landfill liners landfill covers Bio gas from landfills computations of gas quantity and its management
CE-663 Solid Waste and Industrial Wastewater Analysis Lab
Determination of calorific value of different types of wastes Determination of molecular formula using CHNS analyzer Determination of total organic carbon of wastes Determination of moisture content density of wastes
Physical and chemical analysis of wastewater from different industries
CE-664 Minor Project - I
GROUP lsquoErsquo SUBJECTS
CE-7111 Environmental Impact Assessment and Audit
Environmental Impact Assessment ndash Definition Objectives Types ndash Rapid and Comprehensive EIA EIS FONSI Step-by-step procedure for conducting EIA and Limitations of EIA Prevention of Significant Deterioration (PSD) Programme Frame work of Impact assessment scope and contents of EIA methodologies and techniques of EIA
30
Attributes Standards and Value functions Public participation in EIA Environmental Management Plan (EMP) and Disaster Management Plan (DMP) EIA Case Studies ndashThermal Power Plant Mining Fertilizer Construction Projects Air port Water and Wastewater Treatment Plants
CE-7112 Remote Sensing and GIS in Environmental Engineering
Remote Sensing Definition ndash Ideal Remote Sensing System ndash Sensors and Types ndash Remote Sensing Satellite ndash IRS and INSAT specifications ndash Applications of remote sensing ndash DIP Techniques GIS Definition ndash Data and Types ndash Sources of data - Global Positioning System (GPS) ndash Data Structure ndash Types of Analysis ndash Errors ndash Applications of GIS Optimal Routing of Solid wastes using GIS ndash Case Study Environmental Siting of Industries and Zoning Atlas Development Re-modeling of Water Distribution System using GIS ndash Case Study Sustainable Urban Development Planning using GIS Environmental Degradation Assessment using RS and GIS Ground water vulnerability modeling using GIS
CE-7121 Air Quality Modeling
Introduction to air pollution modeling Approaches to model formulation Model Classification Criteria for model selection Air pollution meteorology ndash meteorological parameters stability classification plume rise plume behavior dispersion parameters Basic diffusion equation deterministic numerical and statistical modeling approach Introduction to boundary layer turbulence Physical modeling approach stochastic modeling approach to air pollution dispersion Theory of Gaussian plume model and its application Introduction to indoor air quality models ISCST3 CALINE4 ROADAIR Case studies
CE-7122 Hazardous Waste Management
Introduction Sources Classification Regulations for Hazardous Waste Management Hazardous Waste Characterization Designated Hazardous Wastes Waste Minimization and Resource Recovery ndash Approaches Development of a Waste Tracking System Selection of waste Minimization Process Case Studies Transportation of Hazardous Waste ndash requirements regulations containers bulk and non-bulk transport Emergency Response Physico-chemical Chemical and Biological Treatment of hazardous waste Thermal treatment - Incineration and pyrolysis Sanitary landfill ndash design approach leachate and gaseous collection system Facility Siting and Process Selection for treatment storage disposal facility (TSDF) Soil contamination and site remediation ndash bioremediation processes monitoring of disposal sites
CE-7123 Occupational safety and Health
Introduction Occupational Safety and Health Act Occupational Safety and Health Administration Right to know Laws Indian Acts ndash Labour Act Factories Act OSHA Accident ndash Causation investigation methods and different models Ergonomics ndash need Task Analysis Preventing Ergonomic Hazards Ergonomics Programme Occupational Hazard and Control - Hazard Analysis Human Error and Fault Tree Analysis Emergency Response Hazards and their control in different manufacturing and processing industries Fire Prevention and Protection - types of Fire Fire Development and its Severity Effect Extinguishing Fire Electrical Safety Product Safety Occupational Health - Health and Safety Considerations Personal Protective Equipment Health problems in different types of industries ndash construction textile steel and food processing pharmaceutical occupational Health and Safety considerations in Wastewater Treatment Plants
CE-713 Self study Open Area Seminar II
CE-714 Minor Project II
CE-715 Major Project Part-I
GROUP lsquoFrsquo SUBJECTS
CE-811 Major Project Part II
Syllabus for M Tech (Hydraulics and Water Resources Engineering)
Scheme for MTech ( Hydraulics and Water Resources Engineering)
Sem
Gro
up
Course details Course
Code
L T P Internal
Marks
External
Marks
Total
Marks
Credit
s
A Advanced Mathematics CE 531 3 0 0 50 100 150 3
I Advanced Hydrology CE 532 3 0 0 50 100 150 3
Advanced Open Channel Hydraulics CE 533 3 0 0 50 100 150 3
Hydraulic Engg Lab-1 CE 534 0 0 2 30 70 100 2
B Advanced Fluid Mechanics CE 581 3 0 0 50 100 150 3
Water Power Engineering CE 582 3 0 0 50 100 150 3
Hydraulics Engg Laboratory-II CE 583 0 0 2 30 70 100 2
Self study open area seminar-I CE 584 0 0 2 50 0 50 1
21Hoursweek 1000 20
II
C Planning amp management of Water Resources CE 631 3 0 0 50 100 150 3
Elective ndashI any one of the following
Ground water Hydrology
Coastal Engg
Hydrometeorology
CE 6321
CE6322
CE 6323
3 0 0
50 100 150 3
Elective ndash II any one of the following
Design of Hydraulic structures
Advanced irrigation and drainage Engg
Water pollution control and stream pollution
CE 6331
CE 6332
CE 6333
3 0 0
50 100 150 3
Hydraulics Engg Laboratory-III CE 634 0 0 2 30 70 100 2
D Elective ndash III any one of the following
Application of Geotech Engg And GIS in water
resources
River mechanics and sediment transport
Urban storm water drainage
CE 6811
CE 6812
CE 6813
3 0 0
50 100 150 3
Elective ndash IV any one of the following
Design of flood control and river training works
Water Resources Economics
Hydrodynamics stability
CE 6821
CE 6822
CE 6823
3 0 0
50 100 150 3
Hydraulic Engg Lab- IV CE 683 0 0 2 30 70 100 2
Minor project -I CE 684 0 0 2 50 00 50 1
21Hoursweek 1000 20
III E Elective ndash V any one of the following
Environmental Impact Assessment
Subsurface investigations
Water and soil conservation Engg
CE 7311
CE 7312
CE 7313
3 0 0
50 100 150 3
Elective ndash VI any one of the following
System Techniques in Water Resources Engineering
Computational Hydraulics
Hydro Informatics and Simulations
CE 7321
CE 7322
CE 7323
3 0 0
50 100 150 3
Self Study open area Seminar CE733 0 0 2 100 00 100 2
Minor Project ndash II CE 734 0 0 4 0 300 300 6
Major Project ndash I CE 735 0 0 6 200 00 300 6
18 HrsWeek 1000 20
IV F Major Project ndash II CE 831 0 0 6 00 1000 1000 15
6 Hrswk 1000 15
Grand Total 3500 70
ADVANCED MATHEMATICS
Paper Code L T P Cr
CE 531 3 0 0 3
Numerical method Finite Differences Numerical integration and differentiation Numerical solution of ordinary
differential equations and their application to engineering structures Poissonrsquos Laplacersquos and bi-harmonic
equations Relaxation methods and their application to Civil Engineering problems Complex variables Conformal
mapping and Swartz-Christoffel transformation applied to flow problems
Statistics and Probabilities Statistical parameters Discrete and continuous distributions frequency analysis
confidence limits Regression and correlation Stochastic modelling and Time series analysis Chi-square test of
goodness of fit Sensitivity analysis and decision making
Advanced Computer programming techniques and their applications to Engineering problems
Optimization techniques using Linear Non-linear and dynamic programming
ADVANCED HYDROLOGY
Paper Code L T P Cr
CE 532 3 0 0 3
Review of basic principles of hydrology Concepts of linear and non-linear modelling in rainfall-Runoff models
Probability and statistical analysis in hydrology correlation and regression analysis Lumped and distributed flood
routing methods Flood estimation methods
Time Series Analysis
Synthetic data generation Simple and multiple linear regression
At site frequency analysis
Analysis of low flows
Stream flow forecasting
Introduction to stochastic modelling and time series analysis
ADVANCED OPEN CHANNEL HYDRAULICS
Paper Code L T P Cr
CE 533 3 0 0 3
Energy and momentum equation Effect of Non-uniform velocity distribution
metering of flow Hydraulic Jump Formations of jump in expanding and contracting channel jump type jump
control jump on sloping floors Gradually varied steady flow and rapidly varied steady flow in open channels
surface profiles in GVF-analysis different method of computations Chowrsquo-s methods standard step method finite
difference method Unsteady Flow Waves celerity of wave boundary conditions standing and progressive wave
positive and negative surges Dam break problem deep water group velocity solitary wave Introduction to Fluvial
hydraulics sediment transport
HYDRAULIC ENGINEERING LAB I
Paper Code L T P Cr
CE 534 0 0 2 2
I) Computation of energy momentum correction factors by use of current meter and pitot tube
II) Calibration of weir and venturi-flumes determination of modular limit
III) Normal critical and brink depth-their experimental Verification and determination of Manningrsquos n
IV) Backwater profiles
V) Hydraulic jump characteristics
VI) Bed formations Threshold condition in sediment transport
ADVANCED FLUID MECHANICS
Paper Code L T P Cr
CE 581 3 0 0 3
Review of basic laws of fluid flow in integral and differential form kinematics Ideal fluid flow Newtonian fluid
flow and applications Creeping flow Two dimensional Flow Patterns Sink and Source Laplace equation solution
by Graphical method Theoretical concepts of boundary layer Boundary layer theory Turbulent boundary layer
Boundary Layer Separation and its Stability Transition turbulence analysis and Measurement Correlation and
Statistical Theories Fundamentals of compressible flows Modelling and dimensional analysis
WATER POWER ENGINEERING
Paper Code L T P Cr
CE 582 3 0 0 3
Comparative study of Hydro-Thermal and Nuclear Projects Investigations of Hydro-electric projects-types of
development nature of demand and supply interconnection pondage and storage
Design of intakes gates air inlet valves penstocks and anchor blocks Power canals Forebay
Type of turbines their selection Design of turbine components like scroll casing runner draft tube governing of
turbine
Characteristics and model studies of turbines
Water hammer phenomenon physical interpretation water hammer studies by different methods for sudden and
gradual closure of valve
Surge tanks governing equation for analysis stability calculation of surge by different methods surge in power
canals surge control Design principles of Power House
HYDRAULIC ENGINEERING LABORATORY II
Paper Code L T P Cr
CE 583 0 0 2 2
Flow visualisation studies Boundary layer drag and lift on immersed bodies Measurement of turbulent
quantities) some experiments on wind tunnel
PLANNING AND MANAGEMENT OF WATER RESOURCES
Paper Code L T P Cr
CE 631 3 0 0 3
Principles of engineering economics discounting techniques un-certainity planning horizon Selection of optimal
alternatives Application of linear non linear and dynamic programings in water resources Optimal sequencing and
scheduling of resources Planning of water resources projects cost ndashbenefit analysis for irrigation water power and
floods control projects
Principles and practice of water resources planning and management Purposes water resources developments
Engineering economy in water resources planning
Reservoir planning river basin development Factors affecting irrigation and power development examples of
multipurpose project in India
Storage and related problems optimum storage Rule curve minimum storage and its effect on the cost of power
Computer applications in the designs of water resources systems Water shed management Management of reservoir
operations
GROUND WATER HYDROLOGY
Paper Code L T P Cr
CE 6321 3 0 0 3
Introduction Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel
transformation and its application for ground water flow and seepage problems Numerical Techniques for solution
of ground water flow
Ground water movement Darcyrsquos law permeability hydraulic conductivity ground water in perforated regions
Isotropic and anisotropic aquifers and general flow equations Multiple well system partially penetrating wells
image wells mutual interference of wells
Ground water modeling techniques Porous media models analog models and digital computer models
Investigations of ground water Surface and subsurface investigation of ground water Water level measurement
fluid conductivity Storage and exploration of ground water Design Construction and Maintainence of wells
simulation of ground water basin Application of remote sensing for ground water
Artificial recharge of ground water Concept of artificial recharge re-charge methods recharge on water
spreading recharge mound and induced recharge General hydro-dynamic equations flow nets in isotropic and
anisotropic medium Water harvesting and legislation
COASTAL ENGINEERING
Paper Code L T P Cr
CE 6322 3 0 0 3
Definition-wave classification-linear theory of waves-assumptions and derivations of relationship of wave
characteristics-pressure within a progressive wave wave energy energy flux-wave decay-Transformation of waves-
Fundamental aspects of stokes theory
Reflection Refraction Diffraction of wave-Breaking of waves-types criterion and importance of breaking- wave
force on structure-vertical sloping curved and stepped barrier-force due to non-breaking breaking and broken
waves-Force on piles
Need for forecasting- SMB and PNJ methods of wave forecasting
Origin and classification of tides Karwinrsquos equilibrium theory of tides-effects on structure-seiches and tsunamis
Types of sediment and movement-types of beaches and beach profile Long Shore drift and its engineering
significance Causes of coastal erosion and methods of protection Introduction to outfall design necessity and few
design examples
HYDROMETEOROLOGY
Paper Code L T P Cr
CE 6323 3 0 0 3
Atmosphere General Circulation Composition and Structure of Atmosphere Role of
Meteorology in Hydrology
Precipitation Process ndash Adiabatic Process Stability and Instability of Atmosphere
Atmosphere Thermodynamics
Clouds ndash Classification Formation and Characteristics
Climate Preparation of Climatological norms and Climate Classification
Weather Charts Preparation Analysis and Interpretation Weather Forecast
Monsoon ndash Monsoon Circulation Monsoon Troughs Monsoon Depression and Tropical
Cyclones
Hydro-meteorological Instrumentation and Observations
Use of Radar and Satellites in Hydrology
Storm Analysis Storm Selection Storm Maximization Probable Maximum Precipitation
Meteorological Homogeneity Storm Transposition
Computer applications in the design of hydraulic structures
DESIGN OF HYDRAULIC STRUCTURES
Paper Code L T P Cr
CE 6331 3 0 0 3
Design of spillways energy dissipation below spillways and their construction management
Non-overflow dams Gravity Arch and buttress dams rock fill and earthen dams their design and management at
the site Stress analysis stress concentration around openings Model analysis of hydraulic structures
Design of weirs on permeable foundation silt excluders and different types of silt ejectors and construction
management of diversion head works Case studies of large dams
Foundations design well foundation coffer dams drilled shafts and piled foundations Stability analysis
construction maintenance and testing of foundations Codal provisions for foundation design of these structures
ADVANCED IRRIGATION AND DRAINAGE ENGINEERING
Paper Code L T P Cr
CE 6332 3 0 0 3
Basic Irrigation Development Problems Types of development water rights and disputes Land classification and
development Investigation for irrigation planning water resources conjunctive use of surface and ground water
reclamation of sewage and drainage flow Recharging of groundwater by flood flows
Water requirement of crops Consumptive use depth and frequency of irrigation cropping pattern
Modern methods of irrigation their economics and design irrigation network and irrigation structures Management
of irrigation analysis of existing irrigation projects irrigation losses and wastes irrigation efficiency control and
maintenance of irrigation works
Problems of water logging-salinity and alkalinity land drainage problems- design of surface and sub-surface
drainage system reclamation
Systems approach in planning of irrigation and drainage projects
WATER POLLUTION CONTROL AND STREAM SANITATION
Paper Code L T P Cr
CE 6333 3 0 0 3
Water quality and stream quality standards
Organic self purification-quantitative definition-re-oxygenation-oxygen balance and stream
dissolved oxygen profile-oxygen sag curve-Streeter Phelprsquos equation-Critical deficit problems
Microbial self purification-pathogenic microorganisms of sewage origin-indices of
contamination-enumeration-per-capita contribution-seasonal variations-death rate survival in
the stream environment
Classification of streams-natural self purification process-disposal of wastewater Rational
stream sanitation practices-dual objectives of stream sanitation practices-the science
and art of applied stream sanitation-stream survey-types of stream survey-execution of stream
surveys
Purification in estuaries-evaluation of self purification in estuaries-tides and currents distribution
of waste loads by tidal translation-sea water intrusion-waste assimilation capacity
of estuaries-bacterial contamination-stable wastes
Case studiessimulation studies water quality modelling using qual2E WASP
HYDRAULICS ENGG LABORATORY-III
Paper Code
L T P Cr
CE 634 0 0 2 2
Experiments based on models studies in irrigation engineering river mechanics river flow dynamics and sediment
transport Experiments on instrumentation techniques
APPLICATION OF GEOTECH ENGG AND GIS IN WATER RESOURCES
Paper Code
L T P Cr
CE 6811 3 0 0 3
Introduction sources of energy electromagnetic spectrum electromagnetic radiation reflection transmission and
absorption Interaction of EMR with atmosphere scattering refraction absorption transmission atmospheric
windows Brief review of thermal and microwave remote sensing their utility merit and demerits Introduction
geographical concepts and terminology difference between image processing system and GIS utility of GIS
Various GIS packages and their salient features essentials components of GIS data acquisition through scanners
and digitizers Raster and vector data introduction descriptions raster and vector data raster versus vector raster
to vector conversion remote sensing data in GIS
Introduction importance of water resources and hydrology components of water resources hydrological cycle role
of remote sensing Geo-morphological analysis of watershed determination of various geo-morphometric
parameters using conventional and remote sensing data digital elevation model data input interpolation
techniques surface generation assessment of accuracy extraction of various watershed parameters Irrigation water
management and scheduling performance evaluation of irrigation command areas performance indicators mapping
of irrigation command areas using temporal remote sensing data Flood plain identification and management use of
remote sensing data products digital based extraction of flood plain parameters and indices drought identification
and management conventional approach data requirements and methods drought Indices and its assessment using
remote sensing data
RIVER MECHANICS AND SEDIMENT TRANSPORT
Paper Code L T P Cr
CE 6812 3 0 0 3
River morphology river systems hydraulics regime and dynamics Theory of meandering Inter relationship
between river dimensions sediment load and water flow River response to river training works Local scour around
hydraulic structures Density currents and sedimentation of reservoirs
Introduction sediment properties threshold conditions for uniform sediments exposure and sheltering effects in
non-uniform sediments critical-tri-active stress of non-uniform cohesion-less sediments and cohesive soil regimes
of flow analysis of ripples dunes and anti-dunes resistance to flow and velocity distribution in alluvial streams
Bed load suspended load and wash load computation of bed load for uniform and non uniform sediments
Mechanism of suspension distribution of suspended load computation of suspended load and total load
URBAN STORM WATER DRAINAGE
Paper Code L T P Cr
CE 6813 3 0 0 3
Hydraulics of closed and open drains under different flow conditions unsteady steady and spatially varied flows
Design criteria of drains based on hydraulic considerations
Hydrologic design scale selection of design level Risk analysis of safety margins and safety factors
Design storms precipitation depth intensity duration frequency relationships Design hyetographs from storm
events
Design flows storm sewer design Codal requirements for storm water drainage
DESIGN OF FLOOD CONTROL AND RIVER TRAINING WORKS
Paper Code L T P Cr
CE 6821 3 0 0 3
Basic causes of flood Flood prone areas in India and their problems case history of some important river basins of
India Engineering and administrative methods of flood plane regulation Economic aspects of flood control
schemes cost benefit analysis Flood forecasting flood warning and flood fighting
Morphological study of river behaviour Theories of river meandering and river regimes Necessity principles and
methods of river training Case history of river training works in India and abroad Design of Levees Groynes Cut-
offs and Guide bunds etc River training works for different hydraulic structures
WATER RESOURCE ECONOMICS
Paper Code L T P Cr
CE 6822 3 0 0 3
Principles of engineering economics discounting techniques un-certainity planning horizon Selection of optimal
alternatives Application of liner non-linear and dynamic programmings in water resources Optimal sequencing
and scheduling of resources Planning of water resources projects cost- benefit analysis for irrigation water power
and flood control projects
HYDRO DYNAMIC STABILITY
Paper Code L T P Cr
CE 6823 3 0 0 3
Control volumes and system approach- Stokersquos Gauss and Greenrsquos theorem and applications
Conservation of mass momentum moment of momentum and energy equations
Potential flows Basic flow patterns combination of flow patterns application to civil engineering problems
Conformal transformation Viscous flow Navier-Stokersquos equations Exact and approximate solutions
Boundary layer theory Boundary layer equations and its solution boundary layer separations and its control theory
of stability drag on immersed bodies
Formulation of hydrodynamic stability problems in various situations of flows and particularly for parallel flows
Waves and allied experimental studies Study of laminar to turbulent transition
CE 683 HYDRAULIC ENGINEERING LAB ndashIV
Paper Code L T P Cr
CE 683 0 0 2 2
Application of CAD in hydraulic Engineering Two and three dimensional analysis of gravity dams Seepage and
stability analysis of embankment Design of weirs on permeable foundations Design of canals and transitions
Design of gates and valves Design of pipe networks
ENVIRONMENTAL IMPACT ANALYSIS FOR WATER RESOURCE PROJECTS
Paper Code L T P Cr
CE 7311 3 0 0 3
Objectives of environmental impact assessment methodology for EIA Baseline study scooping checklist scaled
and weighted matrices networks overlays index methods Prediction and Assessment of impacts on air water land
demography and Biological Environment Impact analysis of Hydro power different case studies environmental
Impact Analysis-Laws and Status in India Rehabilitation and resettlement
Identification of process operation imbalances resulting in resources loss and their impact on environment
SUBSURFACE INVESTIGATIONS
Paper Code L T P Cr
CE 7312 3 0 0 3
Introduction amp broad classification of subsurface methods
Direct Methods
Excavation amp Pitting
Well Drilling Techniques
Drill Stem Testing
Geological Well Logs
Indirect Methods
Geophysical Well Logging Electrical Well logging methods Normal amp Lateral Resistivity
Logs Self Potential Logs Induction amp Micro focused logs electrical logging practices
evaluation of aquifer parameters
Radiation logging (Natural gamma neutron amp gamma gamma logging) - Acoustic logs
Caliper logs amp Dip-meter surveys amp their applications in groundwater
prospecting
WATER AND SOIL CONSERVATION ENGINEERING
Paper Code L T P Cr
CE 7313 3 0 0 3
Water conservation Rain water harvesting techniques water shed development ground water recharging check
dams reservoirs and aquifers control of infiltration seepage and evaporation control of effluent and waste water
disposal control of agricultural run off and siltation Plan utilisation of water resources flood planes zone
management reuse and recycling of treated waste water effluent irrigation
Soil Conservation Introduction to soil erosion mechanisms and its causes and control sheet erosion rill erosion
gully erosion control of erosion by bunding terracing contour trenching gully stabilizing check dams drop
spillways chute spillways grass land management and forest management reclamation of saline and usher soils
remediation of contaminated soils Case studies on soil and water conservation practices
SYSTEM TECHNIQUES IN WATER RESOURCES ENGINEERING
Paper Code L T P Cr
CE 7321 3 0 0 3
System Concepts
System concepts definitions needs for system approach different types of
system parameters and variables
Linear Programming
Revision Big M Method duality sensitivity analysis Application of Linear
Programming for Hydraulics amp Water Resource
Non Linear Programming
Unconstrained one Dimensional search methods Dichotomous search method
Fibonacci Golden section multivariable unconstrained gradient techniques
steepest ascent and descent methods Newtonrsquos methods Application of
Dichotomous search method Fibonacci amp Golden section to the various sectors of
Water Resource Engineering FP methods constrained Lagrangian multiplier
techniques Kuhn Tuckerrsquos conditions penalty function methods
Dynamic Programming
Principle of optimality recursive equations Application of Dynamic
programming to Water Resource Engineering
Stochastic Methods
Queuing theory simulation technique sequencing model Morkovrsquos process
Capitalisation
Annuity benefit-cost analysis Benefit Cost Analysis for multi purpose water
resource projects
Geometric Programming
Polynomial unconstrained minimization problem arithmatics geometric
unequality solution of unconstrained geometric programming constraints
minimization geometric programming with mixed inequality constrained
Games Theory
COMPUTATIONAL HYDRAULICS
Paper Code L T P Cr
CE 7322 3 0 0 3
Introduction to finite element and finite volume techniques in computational fluid dynamics
Numerical solution of Navier-Stokersquos equation and boundary layer equation Reynoldrsquos equation-turbulence
modelling
Separated flows transient flow through pipes surge tanks steady uniform and non-uniform flow through open
channels
Spatially varied flow Numerical solutions unsteady flow through open channels
Application of finite element method in other areas of water resources eg Multiphase flow estuarine and lakes
oceans waves tidal flow etc Specification related to storm water drainage
HYDROINFORMATICS AND SIMULATIONS
Paper Code L T P Cr
CE 7323 3 0 0 3
Introduction
Concept of hydro-informatics scope of internet and web based modelling in water
resources engineering
Introduction to multi criterion decision support system ndash Components for
modelling software
Introduction to Simulation
Different simulation techniques ndash Applications of simulation techniques in
hydraulics
Introduction to Artificial Neural Networks
Networks and its training-Back propagation algorithm Conjugate gradient
algorithm Cascade correlation algorithm Applications of ANN in WRE Genetic Algorithm (GA)
Concept Basic principle of GA Working principle of GA Coding Fitness
function GA Operations Reproduction Cross over Mutation Applications of
GA in Water Resources Engineering
DELHI TECHNOLOGICAL UNIVERSITY
SCHEME OF EXAMINATION
AND
COURSE OF READING
FOR
MTech (Software Engineering)
Syllabus applicable to the students seeking admission to
MTech (Software Engineering) Course
SCHEME
Paper
No
Subject Code
No
Title of the Course Internal
Marks
External
Marks
Total
Marks
Credits Semester
Total
1
2
3
4
GROUP A CO 511
CO 512
CO 513
CO 514
Software Engineering Methodologies
Data Warehousing amp Data Mining
Advances in Internet amp Web
Technologies
Software Engineering Lab
50
50
50
30
100
100
100
70
150
150
150
100
3
3
3
2
1000
(20
credits)
5
6
7
8
GROUP B
CO 561
CO 562
CO 563
CO 564
Software Project Management Artificial Intelligence and Expert Systems
Artificial Intelligence Lab
Self-study Open Area Seminar-I
50
50
30
50
100
100
70
-
150
150
100
50
3
3
2
1
9
10
11
12
GROUP C CO 611
CO 612
CO 613
CO 614
Software Validation Verification amp
Testing
Elective-I
Elective-II
Software Testing Laboratory
50
30
50
50
100
70
100
100
150
100
150
150
3
2
3
3
1000
(20
credits)
12
13
14
15
GROUP D
CO 661
CO 662
CO 663
CO 664
Elective-III
Elective-IV
Lab based on Electives
Minor Project-I
30
50
50
50
70
100
100
-
100
150
150
50
2
3
3
1
16
17
18
19
20
GROUP E
CO 711
CO 712
CO 713
CO 714
CO 715
Elective-V
Elective-VI
Self-study Seminar ndashII
Minor Project-II
Major Project-I
50
50
100
-
-
100
100
-
300
300
150
150
100
300
300
3
3
1
4
4
1000
(15
credits)
21 GROUP F CO 811
Major Project-II
-
1000
1000
15
1000
(15
credits)
List of Electives
Electives I (Group C) Any one subject can be chosen from the following
Software Requirements Engineering
Software Quality amp Metrics
Bio-Informatics
Advances in Information Systems
Modeling and Simulation
Electives II (Group C) Any one subject can be chosen from the following
Real-Time Systems
Quantum Computing
Recent Trends in Distributed Systems
Cluster amp Grid Computing
Pervasive Computing
Electives III (Group D) Any one subject can be chosen from the following
Virtual Reality
Advances in Multimedia Systems
Wireless amp Mobile Communication
Data Security and Cryptography
Fault Tolerant System Design
Electives IV (Group D) Any one subject can be chosen from the following
Digital Image Processing
Neural Networks amp Fuzzy Logic
Biometrics
Robotics Engineering
Pattern Recognition
Electives V (Group E) Any one subject can be chosen from the following
Advances in Software Engineering
Software Architecture amp Design Patterns
Component Based Technology
Intellectual Property Rights
Human Computer Interface
Electives VI (Group E) Any one subject can be chosen from the following
Natural Language Processing
Computer Vision
Machine Learning
Semantic Web
Information Retrieval
First Year MTech (SE) I Semester
CO 511 Software Engineering Methodologies
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Review of Software Engineering Principles amp Techniques Discussion on System
Development amp Methodologies Object-Oriented System Development
Unit 2 Software Engineering Processes Introduction to Object Oriented Paradigm Object-
Oriented Process Models Rational Unified Process (RUP)
Unit 3 Methodologies Yourdon method for software design Modified Yourdon Method
Object Modeling Technique (OMT) of Rumbaugh
Unit 4 Unified Modeling Language (UML) UML diagrams such as use case diagrams class
diagram sequence diagrams state transition diagrams etc
Unit 5 Agile development methodologies
Unit 6 Applications A complete case study of Software development using above
Methodologies Concepts of Computer-Aided Software Engineering
Tools Knowledge about current CASE tools used in the industry
Suggested Readings-
Text Books
1 Ian Sommerville ldquoSoftware Engineeringrdquo 7th Edition Addison-Wesley 2004ISBN 81-
7758-530-4
2 Roger S Pressman ldquoSoftware Engineering ndash A Practitionerrsquos Approachrdquo - 4th edition
McGraw Hill Publications
3 Grady Booch James Rambaugh Ivar Jacobson ldquoUnified Modeling Language Users
Guiderdquo 2nd Edition Addison- Wesley ISBN ndash 0321267974
Reference Books
1 Ivar Jacobson Grady Booch James Rumbaugh ldquoThe Unified Software Development
Processrdquo Pearson Education
2 Yourdon ldquoModern Structured Analysisrdquo PHI
3 KK Aggarwal and Yogesh Singh ldquoSoftware Engineeringrdquo New Age Publications 2009
CO 512 Data Warehousing amp Data Mining
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Data Warehousing - Basic concepts in data warehousing Collecting the requirements
of data warehouse Data Warehouse Architecture Design Implementationamp Maintenance
OLAP in data warehouse Data warehousing and the web Further Development of Data Cube
Technology From Data Warehousing to Data Mining
Unit 2 Data Mining Concepts Data mining primitives Basics of data mining Query language
Designing GUI based on a data mining query language Architectures of data mining systems
Unit 3 Mining Association Rules in Large Databases Association Rule Mining Mining
Single Dimensional Boolean Association Rules from Transactional Databases Mining
Multilevel Association Rules from Transaction Databases Mining Multidimensional Association
Rules from Relational Databases and Data Warehouses From Association Mining to Correlation
Analysis Constraint Based Association Mining
Unit 4 Classification and Prediction Issues Regarding Classification and Prediction
Classification by Decision Tree Induction Bayesian Classification Classification by
Backpropagation Classification Based on Concepts from Association Rule Mining Other
Classification Methods Prediction Classifier Accuracy
Unit 5 Cluster Analysis in Data Mining Types of Data in Cluster Analysis A Categorization
of Major Clustering Methods Partitioning Methods Density Based Methods Grid Based
Methods Model Based Clustering Methods Outlier Analysis
Unit 6 Mining Complex Types of Data Multidimensional Analysis and Descriptive Mining of
Complex Data Objects Mining Spatial Databases Mining Multimedia Databases Mining Time
Series and Sequence Data Mining Text Databases Applications Systems products and research
prototypes Additional themes in data mining Trends in Data mining spatial mining and Web
Mining Web concept mining Web structure mining Web Usage mining
Suggested Readings-
Text Books
1 PPonnian ldquoData Warehousing Fundamentalsrdquo John Wiley
2 MHDunham ldquoData Mining Introductory amp Advanced Topicsrdquo Pearson Education
3 HanKamber MKaufman ldquoData Mining Concepts amp Techniquesrdquo
Reference Books
1 Ralph Kimball ldquoThe Data Warehouse Lifecycle Tool Kitrdquo John Wiley
2 MBerry GLinoff ldquoMaster in Data Miningrdquo John Wiley
3 WHInmon ldquoBuilding the Data Ware housesrdquo Wiley Dreamtech
CO 513 Advances in Internet amp Web Technologies
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Emergence of the Internet Basics notions amp working parts of the Internet E-Mail file
transfer telnet Usenet gopher wais Archie and veronica Internet chat
Unit 2 Web Development Developing Web using HTML XML ASP Concepts of Web
Programming using Scripting Languages such as JavaScript CGI PHP etc Database
Connectivity with MySQL and JDBC
Unit 3 Web Research amp Practices The World Wide Web Impact Opportunities and
Challenges Evolution of Search Engines
Unit 4 Web Search amp Mining Framework Supporting Technologies concepts applications
types amp tools Quantifying the Web
Unit 5 Crawling Techniques The task of a web crawler Crawler algorithms Indexing
techniques Ranking in Web
Unit 6 Advanced Research Topics Duplicate Detection Contextual Search etc
Suggested Readings-
Text Books
1 Raj Kamal ldquoInternet and Web Technologiesrdquo Tata McGraw Hill edition
2 Mark Levene ldquoAn Introduction to Search Engines and Web Navigationrdquo Pearson
Education ISBN 0321306775
3 Soumen Chakrabarti ldquoMining the Web Discovering Knowledge from Hypertext
Datardquo Morgan-Kaufmann Publishers ISBN 1-55860-754-4
Reference Books
1 Wendy Willard ldquoHTML A Beginnerrsquos Guiderdquo Tata McGraw-Hill
2 Chris Bates ldquoWeb Programming building internet applicationsrdquo 2nd edition Wiley
Dreamtech
3 Sebesta ldquoProgramming World Wide Webrdquo Pearson
4 Ullman Larry ldquoPHP and MySQL for Dynamic Web Sitesrdquo Peachpit Press
5 Pierre Baldi Paolo Frasconi Padhraic Smyth ldquoModeling the Internet and the Webrdquo John
Wiley and Sons Ltd ISBN 0470849061
CO 514 Software Lab
Practical - 2 Hrs per week Practical - 100 Marks
Software Lab based on using latest CASE Tools At least one Minor Project to be developed for
an application based on methodologies covered in the course
CO 561 Software Project Management
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction Project Management concepts Process Framework Project Planning
Software Life Cycle Models Artifacts of the Project Management Process
Unit 2 Cost and Scheduling Estimation Models Various Levels of COCOMO for Cost
Effort Schedule and Productivity Estimation Approaches to Effort Cost Estimation and
Schedule Estimation factors through COCOMO II Putnam Estimation Model Algorithmic
models
Unit 3 Project Management Techniques Project Organizations and Responsibilities
Establishing Project Environment Risk Management Process Project Tracking and Control
Defect Tracking Concepts such as Process monitoring and audit Reviews Inspections and
Walkthroughs
Unit 5 Risk Estimation What is Risk Framework for Managing Risks Risk Identification
Risk Analysis and Prioritization Risk Avoidance and Mitigation Strategies Risk Monitoring
Estimating
Unit 4 Activity Planning including CPM and PERT Network planning model Activity-on-
arrow network Precedence network Forward pass Backward pass Critical path Slack and
float
Unit 6 Advance Topics in Software Project Management Discussion on future Software
Project Management Practices amp Modern Project Profiles Next Generation Software Economics
Modern Process Transitions
Suggested Readings-
Text Books
1 Watts S Humphrey ldquoManaging the Software Processrdquo Pearson Education
2 Walker Royce ldquoSoftware Project Managementrdquo Pearson Education
3 Pankaj Jalote ldquoSoftware Project Management in Practicerdquo Pearson Education
Reference Books
1 Bob Hughes ldquoSoftware Project Managementrdquo TMH
2 Chris Kemerer ldquoSoftware Project Management Readings and Casesrdquo
CO 562 Artificial Intelligence amp Expert Systems
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction The AI Problems AI Techniques Basic Problem solving methods state
space search problem characteristics Production systems characteristics issues in design of
Intelligent search algorithm
Unit 2 Heuristic search Techniques Hill climbing techniques Best First search Problem
Reduction Constraint Satisfaction Means-End Analysis
Unit 3 Knowledge Representation Knowledge Representation issues Knowledge
Representation using Predicate logic Semantic Nets Semantic Frames Conceptual Dependency
scripts Knowledge representation with uncertainty
Unit 4 Programming Languages Fundamental and concepts of Programming languages like
Prolog or Lisp Relationship of languages with Knowledge representation and inferences
Unit 5 Expert Systems What and Why of expert systems Structure of an Expert system
interaction with an expert system Design of an Expert system implementing expert system shell
Expert System Development techniques amp tools with Case Study Construction of Programs
using different data structure
Unit 6 Advanced topics Applications of AI in Game Playing amp Natural Language Processing
Concepts of Fuzzy Logic Introduction to Intelligent Agents
Suggested Readings-
Text Books
1 Artificial Intelligence E Rich and K Knight TMH 2nd ed 1992
2 Introduction to Expert Systems Peter Jackson AWP MA 199
3 Introduction to AI and Expert Systems DW Patterson PHI 1992
Reference Books
1 Artificial Intelligence - an Engineering Approach RJ Schalkoff McGraw Hill Int
Ed Singapore 1992
2 Principles of AI NJ Nilsson Narosa Publ House 1990
3 Artificial Intelligence Structures and Strategies for Complex Problem Solving (5th
Edition) George F Luger 2005 Addison-Wesley ISBN-10 0321263189
4 Artificial Intelligence A Guide to Intelligent Systems (2nd Edition)Michael
Negnevitsky 2005 Addison-Wesley ISBN-10 0321204662
CO 563 Artificial Intelligence Lab
Practical - 2 Hrs per week Practical - 100 Marks
Objective of the course - To develop intelligent systems in different engineering domains like
Games Theorem Proving Natural Language Processing etc
CO 564 Self-study Open Area Seminar-I
Practical - 2 Hrs per week Sessional - 50 Marks
Objective of the course - Students should explore the research areas amp industry practices in the
field of Software Engineering Artificial Intelligenceamp other applied areas The students will
submit a symposium on the topics selected
First Year MTech (SE) II Semester
CO 611 Software Validation Verification amp Testing
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introductory concepts Verification ampValidation Terminologies like Goals Role
Objectives Limitations Approaches amp Applicability
Unit 2 Software Testing Testing Process Limitations of Testing Testing activities
Unit 3 Levels of Testing Unit Testing Integration Testing System Testing
Debugging Domain Testing Regression Testing Slice based testing
Unit 4 Software Testing Techniques Detail study of Functional Testing Structural Testing
Object Oriented Testing
Unit 5 Software Testing Tools Taxonomy Methodology to evaluate automated testing Using
tools Load Runner Win runner and Rational Testing Tools Java Testing Tools JMetra JUNIT
Cactus and other recent tools
Unit 6 Advanced Topics on Testing Prioritizing the Test-cases Web Applications Testing
Off-the-shelf component testing security testing Data-warehouse Automated test data
generation
Suggested Readings
Text Books
1 Paul C Jorgenson Software Testing A Craftsmanrsquos approach CRC Press 1997
2 Desikan Ramesh Software Testing principles and Practices Pearson Education
Reference Books
1 William E PerryEffective Methods for Software Testing John Wiley
2 Steven R Rakitin Software Verification and Validation for Practitioners and Managers
2nd edition Artech House
3 Boris Beizer ldquoSoftware Testing Techniquesrdquo Second Volume Second Edition Van
Nostrand Reinhold New York 1990
4 Louise Tamres ldquoSoftware Testingrdquo Pearson Education Asia 2002
5 Boris Beizer ldquoSoftware System Testing and Quality Assurancerdquo Van Nostrand einhold
New York 1984
6 Glenford Myers ldquoThe Art of Software Testingrdquo John Wiley amp Sons Inc New York
1979
CO 612 Software Testing Lab
Practical - 2 Hrs per week Practical - 100 Marks
Objectives of the course -Software Testing Lab where hands-on experience on various Testing
Tools A project development for an application using these tools
Elective I Group C
Lectures - 3 Hrs per week Theory - 150 Marks
CO 613
Elective II Group C
Lectures - 3 Hrs per week Theory - 150 Marks
CO 614
Elective III Group D
Lectures - 3 Hrs per week Theory - 150 Marks
CO 662
Elective IV Group D
Lectures - 3 Hrs per week Theory - 150 Marks
CO 663
CO 664 Minor Project I
Practical - 2 Hrs per week Sessional - 50 Marks
The objective of this course is to develop complete Software Application- CASE Tool based on
the subjects studied during the Course
Second Year MTech (SE) III Semester
Elective V Group E
Lectures - 3 Hrs per week Theory - 150 Marks
CO 711
Elective VI Group E
Lectures - 3 Hrs per week Theory - 150 Marks
CO 712
CO 713 Self-Study Open Area Seminar -II
Practical - 2 Hrs per week Practical - 100 Marks
Objective of this course - This study should be in continuation with earlier study taken during
the Self-Study Open Area Seminar I and students must present some state-of-art innovative
techniques in the area of interest which can serve as the base-work for a workshopConference
Paper
CO 714 Minor Project -II
Practical - 4 Hrs per week Practical - 300 Marks
Objective of this course - Innovative Development of complete Software Application or a
CASE Tool based on the subjects studied amp area of interest
CO 715 Major Project Part-I
Practical - 3 Hrs per week Practical - 300 Marks
Second Year MTech (SE) IV Semester
CO 811 Major Project Part ndashII
Practical - 6Hrs per week Practical - 500 Marks
Elective I (Group C) CO 613
Software Requirements Engineering
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Software Requirements Essential of Software requirements Different Dimensions of
Software Requirements Good practices for requirements engineering improving requirements
processes and risk management
Unit 2 Software Requirements Engineering Review of various activities of Requirements
Engineering like requirements elicitation requirements analysis documentation amp review
Discussion on current trends in requirements elicitation requirements analysis models and
verifying requirements requirements specification amp requirements prioritization
Unit 3 Software Requirements Management (RM) Principles and practices of RM
Requirements attributes Change Management Process Requirements Traceability Matrix Links
in requirements chain
Unit 4 RM Tools Rational Requisite pro Caliber RM benefits of using a RM tool
Unit 5 Advances in Requirement Engineering Commercial requirements management
techniques amp tools implementing requirements management automation
Unit 6 Latest trends in requirements engineering such as aspect-oriented requirement
engineering agent-based requirement engineering
Suggested Readings
Text Book
1 Rajesh Naik and Swapna Kishore ldquoSoftware Requirements and Estimationrdquo Tata
McGraw Hill
2 Karl E Weigers ldquoSoftware Requirementsrdquo Microsoft Press 1999
3 Ellen Gottesdiener Requirements by Collaboration Workshops for Defining Needs
Addison Wesley 2002
Reference Books
1 Ian Graham Requirements Engineering and Rapid Development Addison Wesley 1998
2 Ivy Hooks and Kristin Farry Customer-Centered Products Creating successful products
through smart Requirements Management Amacom 2001
3 Dean Leffingwell and Don Widrig Managing Software Requirements A Unified
Approach Addison Wesley 1999
Software Quality amp Metrics
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Software Quality Assurance Framework What is Quality Software Quality
Assurance Components of Software Quality Assurance Software Quality Assurance Plan Steps
to develop and implement a Software Quality Assurance Plan
Unit 2 Quality Standards ISO 9000 and Comparison ISO Standards CMM CMMI PCMM 3
Sigma 6 Sigma Software Quality Models
Unit 3 Measurement basics What is Software Metrics Application Areas of Metrics
Categories of Metrics Measurement Scale Axiomatic Evaluation of Metrics on Weyukerrsquos
Properties Analyzing the Metric Data Summary statistics for preexamining data Metric Data
Distribution Outlier Analysis Correlation Analysis Exploring Analysis
Unit 4 Measuring Structure and Size Size Estimation Halstead Software Science Metrics
Information flow Metrics Measuring Quality Software Quality metrics based on Defects
Usability Metrics Testing Metrics Reliability Models
Unit 5 Object Oriented Metrics Coupling Metrics Cohesion Metrics Inheritance Metrics
Size Metrics Reuse Metrics
Unit 6 Advanced topics in software quality Empirical software engineering research in
software quality
Suggested Readings-
Text Books
1 Mordechai Ben MenachemGarry S Marliss ldquoSoftware Qualityrdquo Thomson Learning
2 Stephen H Kan ldquoMetrics and Models in Software Quality Engineeringrdquo Pearson
Education (Singapore) Pvt Ltd 2002
3 Norman E Fenton and Shari Lawrence ldquoSoftware Metricsrdquo PfleegerThomson 2003
Reference Books
1 D Galin ldquoSoftware Quality Assurance From Theory to Implementationrdquo Addison
Wesley
2 Allan C Gillies ldquoSoftware Quality Theory and Managementrdquo Thomson Learning
2003
3 Mike Konrad and Sandy Shrum CMMI Mary Beth Chrissis Pearson Education
(Singapore) Pvt Ltd 2003
Bio-Informatics
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction biology physics Biological hierarchy Information stages Physical
processes Information understanding
Unit 2 Methods of gene sequencing Detailed discussion on Sequences searching methods
Unit 3 Gene expression Current and prospective methods of gene profiling Data acquisition
Data standardization Linear approximations of data DNA chips Protein targeting Data
normalization Linear view
Unit 4 Statistics approaches Probabilistic notions Multivariate issues Clustering Information
handling Experimental and computational methods of structure determination for proteins and
nucleic acids
Unit 5 Ontology Annotation of genes their products and functions System biology evolution
hierarchy Medical informatics Software support Software availability Software targets Text
parsing BioPerl Statistics R-system
Unit 6 Recent Advances amp Applications of Bio-Informatics Recent trends in Computing
with bio-systems
Suggested Readings
Text Books
1 David W Mount ldquoBioinformatics Sequence and Genome Analysisrdquo Cold Spring
Harbor Laboratory Press
2 Andreas D Baxevanis ldquoBioinformatics A Practical Guide to the Analysis of Genes and
Proteinsrdquo Second Edition
3 Richard Durbin Sean R Eddy Anders Krogh Graeme Mitchison ldquoBiological Sequence
Analysis Probabilistic Models of Proteins and Nucleic Acidsrdquo Cambridge University
Press
Reference Books
1 DE Krane and ML Raymer ldquoFundamental Concepts of Bioinformaticsrdquo Pearson
Education 2003
2 B Bergeron ldquoBioinformatics Computingrdquo Prentice ndashHall 2003
Advances in Information Systems
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 E-Commerce Models Applications Creation of E-Commerce Sites Introduction to
ERP Packages
Unit 2 CRM sales Marketing amp Service Management BPOBCP Guidelines Merits-
Demerits Call Centre Brief perspective on technological concepts case studies
Unit 3 E-banking Inter-Banking Intra- Banking Transactions E-Payments Techniques for
incorporating Securities in E-banking Services
Unit 4 E-Learning Models Virtual Campus Video Conferencing Building Online
Community
Unit 5 E-Logistics Logistics amp Supplier Chain Management Warehousing Management
Transportation Distribution Management E-Governance Models Challenges Strategies amp
Tactics E-agriculture Type of Agriculture Information amp Technique dissemination Future
Trade Marketing Query Redressing Systems Information Kiosk IVR Case Study
Unit 6 Knowledge Management (KM) Components amp Type of knowledge Knowledge
building Models KM architecture KM Tools Approaches Approaches to GISGPS Nature of
Geographic Data Getting Map on Computers Standards Design Implementation amp
Deployment phases
Suggested Readings
Text Books
1 M Papazoglou and PMA Ribbers E-Business Organizational and Technical Foundations John Wiley and Sons
2 Daryl Morey Mark Maybury and Bhavani Thuraisingham Knowledge Management Classic and Contemporary Works
3 Basics of Ecommerce NIIT PHI
Reference Books
1 Erfan Turban et al Electronic CommercendashA Managerial Perspective Pearson Education
2 Andrew V Winston Electronic Commerce ndash a Mangerrsquos guideR Kalokota Pearson
Education
Modeling amp Simulation
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Basic Simulation Modeling The Nature of Simulation Systems Models and Types of
Simulation Advantages Disadvantages and Pitfalls of Simulation
Unit 2 Modeling Complex Systems Introduction List Processing in Simulation Approaches to
Storing Lists in a Computer
Unit 3 Simulation Software Comparison of Simulation Packages with Programming
Languages
Unit 4 Classification of Simulation Software General-Purpose Simulation Packages
Object-Oriented Simulation
Unit 5 Building Valid Credible and Appropriately Detailed Simulation Models
Experimental Design Sensitivity Analysis
Unit 6 Optimization Simulation of Manufacturing Systems
Suggested Readings-
Text Books
1 Frank L Severance System Modeling and Simulation - an Introduction John Wiley
2 Simulation Modeling and Analysis Third Edition Law Kelton (Mc-Graw Hill)
Elective II (Group C) CO 614
Real-Time Systems
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Real-time systems Real-time systems models Types of real-time systems Internal
structure of real-time systems Performance measures Examples of real-time systems and real-
world applications Modeling amp Designing real-time systems
Unit 2 Real-Time Process Management Task scheduling for Uniprocessor systems handling
priorities with critical section interrupts task allocation amp scheduling for multiprocessor
systems adaptive scheduling
Unit 3 Programming Environment In depth Knowledge of RTOS programming languages
tools amp techniques
Unit 4 Real-Time System Design Design techniques for Reliability Fault Tolerance amp other
application specific quality considerations
Unit 5 Trends in Real-Time System Design amp Development in fields such as Robotics
Unit 6 Introduction to research topics
Suggested Readings-
Text Books
1 AC Shaw Real-Time Systems and Software Wiley
2 JE Cooling Real-Time Software Systems International Thompson Computer Press
3 WA Halang and KM Sacha Real-Time Systems World Scientific
Reference Books
1 Real-Time Systems Design and Analysis PH Laplante IEEE Press
2 Real-Time Systems J Liu Prentice-Hall 2000
3 Real-Time Computer Control R Bennett Prentice-Hall
4 Real-Time Systems CM Krishna and KG Shin McGraw-Hill
Quantum Computing
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction to Quantum Computers Qubits amp their representation
Unit 2 Quantum Elements Logic Gates Circuits Architectures Algorithms
Unit 3 Quantum Information Quantum Key Distribution teleportation Single photons EPR
pairs
Unit 4 Grid Computing Data and Computational Grids Grid Architectures and its relations to
various distributed technologies Autonomic computing Cluster Setup amp its advantages
Unit 5 Performance models amp simulations Networking protocols amp IO Messaging Systems
Examples
Unit 6 Process Scheduling Load Sharing amp Balancing Distributed Shared memory parallel
IO Pervasive Computing concepts amp scenarios Hardware amp software Device Connectivity
Suggested Readings-
Text Books
1 Introduction to Quantum Computing Philip Kaye etal Oxford University Press
2 Introduction to Quantum Computers Gennady Berman World Scientific
3 Quantum Computation and Quantum Information M Nielsen and I Chuang
Cambridge University Press Cambridge 2000
Reference Books
1 Classical and Quantum ComputationA Yu Kitaev AH Shen and MN Vyalyi
American Mathematical Society Providence 2002
2 Problems amp Solutions in Quantum Computing amp Information WH Steeb and Y
HardyWorld Scientific River Edge NJ 2004
Recent Trends in Distributed Systems
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction Distributed System Models Inter-process Communication issues in
design of Distributed systems current amp future
Unit 2 Communications Layered Protocol Distributed Objects amp Remote Invocation Remote
Procedure Call
Unit 3 Time Logical clocks vector clocks direct dependency clocks matrix clocks
Unit 4 Resource Allocation Distributed Shared Memory Process Scheduling Load Balancing
amp Load Sharing Mutual Exclusion Election algorithms
Unit 5 Distributed File Systems Coordination amp Agreement Distributed Transaction
Consistency amp Replication Consistency Models Distribution amp Consistency Protocols
Unit 6 Advanced Topics in Distributed Systems Parallel Processing Parallel amp Distributed
Programming Case Studies in detail amp research directions
Suggested Readings-
Text Books
1 Distributed Operating Systems Concepts and Design PKSihna PHI 2007
2 Distributed Systems Principles and Paradigms 2nd Ed Andrew S Tanenbaum and
Maarten Van Steen Prentice Hall 2007 3 Distributed Operating Systems and Algorithms R Chow T Johnson Addison-
Wesley Publishing Company 1997 ISBN 0-201-49838-3
Reference Books
1 Distributed Systems Concepts and Design 4th Ed by Coulouris G Dollimore J
and Kindberg T Addison-Wesley 2006
Cluster amp Grid Computing
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Cluster Computing Introduction to concepts in Cluster based distributed computing
Hardware technologies for cluster computing and software for cluster computing and different
Software Architecture for Cluster Computing
Unit 2 Programming Programming Models and Paradigms features and performance of
standard MPI variants Derived data types communicators
Unit 3 Resource management and scheduling Managing cluster resources single system
images system level middleware distributed task scheduling monitoring and administering
system resources Parallel IO and Parallel Virtual File System Scheduling Condor Maui
Scheduler Portable Batch System (PBS)
Unit 4 Grid Computing Grids and Grid Technologies Programming models and
Parallelization Techniques Grid Security Infrastructure Setting up Grid deployment of Grid
software and tools and application execution
Unit 5 Standard application development tools and paradigms Performance evaluation
tools HINT netperf netpipe ttcp Iperfmessage
Unit 6 Data Management Application Case Study Molecular Modeling for Drug Design and
Brain Activity Analysis Resource management and scheduling
Suggested Readings-
Text Books
1 William Gropp Ewing Lusk Thomas Sterling Beowulf Cluster Computing with
Linux 2nd edition MIT Press
2 Bart Jacob Michael Brown Introduction to grid computing
3 Gregory F Pfister In Search of Clusters The ongoing battle in lowly parallel
computing Second Edition Prentice Hall Publishing Company 1998
Reference Books
1 MPI The Complete Reference - 2nd Ed by Marc Snir et al The MIT Press 1998
2 Parallel Programming with MPI by Peter Pacheco Morgan Kaufmann 1998
3 Using MPI-2 Advanced Features of the Message Passing Interface William Gropp
Ewing Lusk Rajeev Thakur The MIT Press 1999
4 How to Build a Beowulf ndash A Guide to the Implementation and Application of PC
Clusters by Thomas Sterling John Salmon Donald J Becker and Daniel F Savarese
MIT Press 1999
Pervasive Computing
Lectures - 3 Hrs per week Theory - 150 Marks
Unit1 Introductory concepts Brief History and Emerging Trends Principles
Application Architectures Software architectures amp middleware Interactions between
humans and (ubiquitous) computers Context-aware computing
Unit 2 Devices and interfaces in Pervasive Computing Systems Hardware
Software Technology trends Connectivity Issues Protocols Management Issues and
Mechanisms Operating System issues in Pervasive Computing
Unit 3 Detailed discussion on Wireless Application Protocol (WAP) Architecture
Infrastructure Security Wireless Mark-up Language WAP Push Technology IMode
and Emerging Trends Pervasive Computing and Web-based Applications Issues
Protocols Transcoding Authentication of Clients over Web Pervasive Web
Application Architectures Introduction Scalability and Availability Issues Web-
enabled Pervasive Computing Application Development Issues and Mechanisms
Architectural Issues and Choices
Unit 4 Voice-enabling Pervasive Computing Systems Introduction Voice
Standards Speech Applications Security Personal Digital Assistants in Pervasive
Computing PDA Operating Systems Device Characteristics Software Components
Standards Applications
Unit 5 User Interface in Pervasive Computing Architectures amp Implementation
issues Architectures Implementation of User Interface Architectures Smart Card-
based Authentication Mechanisms over the Internet Applications
Unit 6 Study of social aspect amp implications of Pervasive Computing
implications on privacy security and autonomy Importance of Security
Cryptographic Patterns and Methods Cryptographic Tools Secure Socket Layer
System and legal safeguards Cost-benefit and market forces Deployment and
evaluation of solutions scalability reliability maintenance User-centric evaluation
Deployment and evaluation of solutions scalability reliability maintenance User-
centric evaluation amp Emerging trends
Suggested Readings-
Text Books
1 Jochen Burkhardt Horst Henn Stefan Hepper Thomas Schaec amp Klaus
Rindtorff Pervasive Computing Technology and Architecture of Mobile Internet
Applications Pearson Education New Delhi 2007
2 S K S Gupta G G Richard amp L Schwiebert Fundamentals of Mobile and
Pervasive Computing Frank Adelstein Tata McGraw-Hill New Delhi 2005
3 Uwe Hansmann L Merck M S Nicklous T Stober Pervasive Computing
Handbook Springer-Verlag Berlin 2001
Reference Books
1 Burkhardt Horst Henn Stefan Hepper Pervasive Computing Technology and
Architecture of Mobile Internet Applications Thomas Pearson Education New
Delhi 2007
2 S K S Gupta G Richard amp L Schwiebert Fundamentals of Mobile and
Pervasive Computing Tata McGraw-Hill New Delhi 2005
Elective III (Group D) CO 662
Virtual Reality
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Virtual reality amp Virtual reality systems Real-time computer graphics Overview of
application areas
Unit 2 Virtual Reality Hardware Sensor hardware display systems acoustic hardware
integrated VR systems
Unit 3 3D Computer Graphics The virtual world space Perspective projection Stereo vision
3D clipping Color theory 3D modeling illumination models shading algorithms Hidden
surface removal realism
Unit 4 Geometrical transforms Frames of reference 3D transforms instances picking flying
scaling the VE Collision detection
Unit 5 Animating the Virtual Environment Animation basics Using MAYA Human Factors
Perception Persistence of vision Stereopsis Sound perception Equilibrium
Unit 6 Physical Simulation Simulation of physical systems mathematical modeling collisions
projectiles introduction to dynamics motion kinetmatics
Suggested Readings
Text Books
1 Gregory C Burdea amp Philippe Coiffet Virtual Reality Technology Second Edition John
Wiley amp Sons Inc
2 William RSherman Alan Craig Understanding Virtual Reality interface Application and
Design Elsevier (Morgan Kaufmann)
3 Bill Fleming 3D Modeling and surfacing Elsevier (Morgan Kauffman)
Reference Books
1 David HEberly 3D Game Engine Design Elsevier
2 John Vince Virtual Reality Systems Pearson Education
Advances in Multimedia Systems
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Multimedia System Design Multimedia Elements Multimedia Applications
Multimedia System Architecture Defining Objects for Multimedia Systems Multimedia Data
Interface Standards Multimedia Databases Multimedia InputOutput storage amp Retrieval
Technologies
Unit 2 Compression and Decompression Types of Compression Binary Image Compression
Schemes Color Gray Scale and Still-Video Image Compression Video Image Compression
Audio Compression
Unit 3 Data and file Format Standards Rich-Text Format Resource Interchange File Format
MIDI Files Format JPEG DIB File Format and Motion Image MPEG Standards
Unit 4 Multimedia Application Design Multimedia Application Classes Types Of Multimedia
Systems Virtual Reality Design Components of Multimedia System Organizing Multimedia
Databases Application Workflow Design Issues Distributed Application Design Issues
Unit 5 Distributed Multimedia Systems Components of A Distributed Multimedia System
Distributed Client-Server Operation Multimedia Object Server Multiserver Network
Topologies Distributed Multimedia Databases Managing Distributed Objects
Unit 6 Latest Topics Advances in Multimedia Communication amp Discussion on some recent
applications with Case study
Suggested Readings-
Text Books
1 Multimedia System Design Prabhat K Andleigh Kiran Thakur PHI
2 Fundamentals of Multimedia Ze-Nian Li and Mark S Drew Pearson Prentice Hall
3 Multimedia Concepts and Practice Stephen McGloughlin Prentice Hall
Reference Books
1 Image and Video Compression Standards Algorithms and Architecture V Bhaskaran
and K Konstantinides 2nd ed Kluwer Academic Publishers
2 Multimedia Communications Applications Networks Protocols and Standards Fred
Halsall Addison-Wesley
3 Multimedia computing communications and applications Steinmetz Ralf Prentice
Hall
Wireless amp Mobile Communication
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction Network Technologies and Cellular Communications Discussion on
Bluetooth ampGSM Introduction to Mobile Computing novel applications limitations and
architecture
Unit 2 (Wireless) Medium Access Control Motivation for a specialized MAC (Hidden and
exposed terminals Near and far terminals) SDMA FDMA TDMA CDMA
Unit 3 Mobile Architecture Mobile Network Layer Mobile IP (Goals assumptions entities
and terminology IP packet delivery agent advertisement and discovery registration tunneling
and encapsulation optimizations) Dynamic Host Configuration Protocol (DHCP)
Unit 4 Mobile Transport Layer Traditional TCP Indirect TCP Snooping TCP Mobile TCP
Fast retransmitfast recovery Transmission time out freezing Selective retransmission
Transaction oriented TCP
Unit 5 Mobile Ad hoc Networks (MANETs) Overview Properties of a MANET spectrum of
MANET applications routing and various routing algorithms security in MANETs
Unit 6 Protocols and Tools Wireless Application Protocol WAP (Introduction protocol
architecture and treatment of protocols of all layers) Bluetooth (User scenarios physical layer
MAC layer networking security link management) and J2ME Latest Technologies
Suggested Readings-
Text Books
1 Mobile and Personal communication System and Services- Raj Pandya
2 Wireless Communication and Networks- William Stallings
3 Wireless and Personal Communications Systems Vijay Garg Joseph Wilkes Prentice-
Hall Englewood Cliffs NJ 1996
Reference Books
1 Fundamentals of Wireless Communication David Tse and Pramod Viswanath
Cambridge University Press 2005
Data Security ampCryptography
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction to Data Security General Security Principles Communication Security
Design of Secure System
Unit 2 Conventional Encryption Principles Conventional encryption algorithms cipher block
modes of operation location of encryption devices key distribution Approaches of Message
Authentication Secure Hash Function and HMAC
Unit 3 Public-key cryptography Principles Recent Public key cryptography algorithms such
as RSA DSS etc
Unit 4 Digital signatures digital Certificates Certificate Authority and key management
Kerberos X509 Directory Authentication Service
Unit 5 Latest Trends and solutions in Information Security Web Security Firewall Design
Principles Trusted Systems Intrusion Detection System
Unit 6 Recent trends in cryptosystem
Suggested Readings-
Text Book
1 Cryptography and Network Security William Stallings (2003) Third Edition Prentice Hall
International
2 Basic Methods of Cryptography Jan C A Cambridge University Press
3 Information Security Intelligence Cryptographic Principles amp Applications Thomas
Calabrese Thomson Learning
Reference Books
1 Modern Cryptography Theory and Practice Wenbo Mao Pearson Education
2 Cryptography and Data Security Dorothy Elizabeth Robling Denning Addison Wesley
Fault Tolerant System Design
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Fundamental Concepts Definitions of fault tolerance fault classification fault tolerant
attributes and system structure
Unit 2 Fault-Tolerant Design Techniques Information redundancy hardware redundancy and
time redundancy
Unit 3 Dependability Evaluation Techniques Reliability and availability models
(Combinatorial techniques Fault-Tree models Markov models) Performance Models
Unit 5 Architecture of Fault-Tolerant Computers (case study) General-purpose systems
high-availability systems long-life systems critical systems Software Fault Tolerance Software
faults and their manifestation design techniques reliability models
Unit 6 Fault Tolerant ParallelDistributed Architectures Shared bus and shared memory
architectures fault tolerant networks Recent topics in fault tolerant systems Security fault
tolerance in wirelessmobile networks
Suggested Readings-
Text Books
1 Fault-Tolerant Computer System Design DK Pradhan 2003
2 Design and Analysis of Fault-Tolerant Digital Systems BWJohnson Addison-Wesley
3 Fault-Tolerant Computing Theory and Techniques Volumes I and II DK Pradhan
Prentice Hall
Reference Books
1 Reliable Computer Systems Design and Evaluation DPSiewiorek and RSSwartz
Digital Press 1992
2 Probability and Statistics with Reliability Queueing and Computer Science Application
KSTrivedi Prentice Hall 1982
Elective IV (Group D) CO 663
Digital Image Processing
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction And Digital Image Fundamentals Digital Image Representation
Fundamental Steps in Image Processing Elements of Digital image processing systems
Sampling and quantization some basic relationships like neighbours connectivity Distance
measure between pixels Imaging Geometry
Unit 2 Image Transforms Discrete Fourier Transform Some properties of the two-dimensional
fourier transform Fast fourier transform Inverse FFT
Unit 3 Image Enhancement Spatial domain methods Frequency domain methods
Enhancement by point processing Spatial filtering Lowpass filtering Highpass filtering
Homomorphic filtering Colour Image Processing
Unit 4 Image Restoration Degradation model Diagnolization of Circulant and Block-Circulant
Matrices Algebraic Approach to Restoration Inverse filtering Wiener filter Constrained Least
Square Restoration Interactive Restoration Restoration in Spatial Domain
Unit 5 Image Compression Coding Interpixel and Psychovisual Redundancy Image
Compression models Error free comparison Lossy compression Image compression standards
Image Segmentation Detection of Discontinuities Edge linking and boundary detection
Thresholding Region Oriented Segmentation Motion based segmentation
Unit 6 Representation and Description Representation schemes like chain coding Polygonal
Approximatiion Signatures Boundary Segments Skeleton of region Boundary description
Regional descriptors Morphology Recognition and Interpretation Elements of Image Analysis
Pattern and Pattern Classes Decision-Theoretic Methods Structural Methods Interpretation
Suggested Readings-
Text Books
1 Digital Image ProcessingRafael C Conzalez amp Richard E Woods AWL
2 Fundamental of Digital Image Processing AK Jain PHI
3 Computer Imaging Digital Image Analysis and Processing SE Umbaugh CRC Press
2005
Reference Books
1 Digital Image Processing Algorithms Pitas I Prentice Hall 1993
Neural Networks amp Fuzzy Logic
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction to Neural Networks Introduction Humans and Computers Organization
of the Brain Biological Neuron Biological and Artificial Neuron Models Characteristics of
ANN McCulloch-Pitts Model Historical Developments Potential Applications of ANN
Unit 2 Essentials of Artificial Neural Networks Artificial Neuron Model Operations of
Artificial Neuron Types of Neuron Activation Function ANN Architectures Classification
Taxonomy of ANN ndash Connectivity Learning Strategy (Supervised Unsupervised
Reinforcement) Learning Rules
Unit 3 Single Layer Feed Forward Neural Networks Introduction Perceptron Models
Discrete Continuous and Multi-Category Training Algorithms Discrete and Continuous
Perceptron Networks Limitations of the Perceptron Model Multilayer Feed forward Neural
Networks Credit Assignment Problem Generalized Delta Rule Derivation of Backpropagation
(BP) Training Summary of Backpropagation Algorithm Kolmogorov Theorem Learning
Difficulties and Improvements
Unit 4 Associative Memories Paradigms of Associative Memory Pattern Mathematics
Hebbian Learning General Concepts of Associative Memory Bidirectional Associative Memory
(BAM) Architecture BAM Training Algorithms Storage and Recall Algorithm BAM Energy
Function Architecture of Hopfield Network Discrete and Continuous versions Storage and
Recall Algorithm Stability Analysis
Unit 5 Classical amp Fuzzy Sets Introduction to classical sets - properties Operations and
relations Fuzzy sets Membership Uncertainty Operations properties fuzzy relations
cardinalities membership functions Fuzzy Logic System Components Fuzzification
Membership value assignment development of rule base and decision making system
Defuzzification to crisp sets Defuzzification methods
Unit 6 Applications Neural network applications Process identification control fault
diagnosis Fuzzy logic applications Fuzzy logic control and Fuzzy classification
Suggested Readings-
Text Books
1 Neural Networks Fuzzy logic Genetic algorithms synthesis and applications S
Rajasekharan and G A Vijayalakshmi pai PHI Publication
2 Neural networks and fuzzy Logic Rao Vallinu Band Rao Hayagriva second
edition BPB Publication
3 Neural Networks- A comprehensive foundation Simon Haykin Pearson Education
Reference Books
1 Fuzzy Logic Intelligence Control and Information John Yen and Reza Langan
Pearson Education
2 SNSivanandam SSumathi etal Introduction to Neural Networks using MATLAB
60 TMH
3 James A Freeman and Davis Skapura Neural Networks Pearson Education
4 Timothy J Ross Fuzzy Logic with Engineering Applications McGraw-Hill Inc
Biometrics
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Basics of a Biometric system Biometric system as a pattern recognition system various
stages of a Biometric system
Unit 2 Characteristics of an efficient Biometric System Comparison of different Biometric
techniques
Unit 3 Various types of common biometric and their applications DNA FACE Gait
Hand and finger geometry Iris Keystroke dynamics odor Retinal scan Voice Signature
Unit 4 Biometric Systems Detailed study of Fingerprint Biometrics recognition system amp Face
Recognition Systems
Unit 5 General concepts and techniques for design and implementation Concepts for these
systems
Unit 6 Advance topics in Biometric system Design and Implementation of other Biometric
systems like Retinal scan Voice signature Research topics in Biometrics
Suggested Readings-
Text Books
1 Biometrics ndash Identity Verification in a Networked World ndash Samir Nanavati Michael
Thieme Raj Nanavati WILEY- Dream Tech
2 Biometrics- The Ultimate Reference- John D Woodward Jr Wiley Dreamtech
3 Biometrics for Network Security- Paul Reid Pearson Education
Reference Books
1 Guide to Biometrics Bolle RM Connell JH Pankanti S Ratha NK Senior
AW Springer Verlag
Robotics Engineering
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Introduction An overview of Robotics and its applications in various applications
domains such as manufacturing assembly and inspection and spray and paintings
Unit 2 Manipulators Manipulator Kinematics Forward and inverse kinematics trajectory
Planning Motions path planning Robotics Programming Languages
Unit 3 Sensing Methods Types of Sensors amp sensor calibration Control Robot Sensing
Unit 4 Computer Vision Illumination techniques imaging geometry stereovision
segmentation
Unit 5 Applications Current and future applications in Industry and study of research aspects in
Robotics
Unit 6 Advance studies
Suggested Readings
Text Books
1 Introduction to robotics J J Craig (Third ed 2003) Prentice Hall
2 Robotic Engineering Richard D Klafter Prentice Hall
3 Robotics Fu K S McGraw Hill
Reference Books
1 An Introduction to Robot Technology P Coiffet and M Chaironze Kogam Page Ltd
2 Industrial Robotics Groover M P Pearson Edu 1983
3 Robotics and Control Mittal R K amp Nagrath I J TMH
4 Robot Dynamics amp Control ndash Mark W Spong and M Vidyasagar John Wiley amp Sons
(ASIA) Pte Ltd
Pattern Recognition
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Pattern recognition fundamentals Basic concepts of pattern recognition fundamental
problems in pattern recognition system design concepts and methodologies example of
automatic pattern recognition systems a simple automatic pattern recognition model
Unit 2 Bayesian decision theory Minimum-error-rate classification Classifiers Discriminant
functions Decision surfaces Normal density and discriminant functions Discrete features
Missing and noisy features Bayesian networks (Graphical models) and inferencing
Unit 3 Maximum-likelihood and Bayesian parameter estimation Maximum-Likelihood
estimation Gaussian case Maximum a Posteriori estimation Bayesian estimation Gaussian
case Problems of dimensionality Dimensionality reduction Fisher discriminant analysis PCA
Expectation-Maximization method Missing features
Unit 4 Sequential Models State Space Hidden Markov models Dynamic Bayesian Non-
parametric techniques for density estimation Parzen-window method K-Nearest Neighbour
method
Unit 5 Linear discriminant functions Gradient descent procedures Perceptron criterion
function Minimum-squared-error procedures Ho-Kashyap procedures Support vector machines
Unit 6 Unsupervised learning and clustering Unsupervised maximum-likelihood estimates
Unsupervised Bayesian learning Criterion functions for clustering Algorithms for clustering K-
means Hierarchical and other methods Cluster validation Low-dimensional representation and
multidimensional scaling (MDS)
Suggested Readings-
Text Books
1 Pattern Classification RODuda PEHart and DGStork John Wiley
2 Pattern Recognition principles Julus T Tou and Rafel C Gonzalez Addision ndashWesley
3 Pattern recognition and machine learning Christopher M Bishop Springer 2006
Reference Books
1 A probabilistic theory of pattern recognition Luc Devroye Laacuteszloacute Gyoumlrfi Gaacutebor Lugosi
Springer 1996
2 Pattern classification Richard O Duda Peter E Hart and David G Stork Wiley 2001
Elective V (Group E) CO 711
Advances in Software Engineering
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Latest Trends in Software Engineering Formal representation of Product Model and
Process Model Study of Meta data Models and Meta activity Model Meta Process Model
Decision oriented meta models
Unit 2 CASE Technology CASE shell design techniques familiarity with a CASE shell
Introduction to method engineering concepts and developing project specific methods
Computer-Aided Method Engineering
Unit 3 Critical System Development Critical System a simple safety critical system
Unit 4 System dependability availability and reliability safety and security
Unit 5 Critical System Specification risk driven specification safety specification security
specification software reliability specification
Unit 6 Research Topics in Software Engineering
Suggested Readings-
Text Books
1 Sangeeta Sabharwal ldquoSoftware Engineering Principles Tools and Techniquesrdquo Umesh
Publications
2 Ian Sommerville ldquoSoftware Engineeringrdquo 7th Edition Addison-Wesley 2004
3 Roger S Pressman ldquoSoftware Engineering ndash A Practitionerrsquos Approachrdquo - 4th edition
McGraw Hill Publications
Resources
1 Towards a Formal Definition of Methods Naveen Prakash Requirements Engineering
Journal Vol 2(1) Springer Verlag London(1997) pp 23-50
2 Engineering Methods From Method Requirements specifications Daya Gupta Naveen
Prakash Requirements Engineering Journal Vol 6 Springer Verlag London 2001
pp135-160
3 On generic method models Naveen Prakash Requirements Engineering Journal Vol 11
(4) Springer Verlag London(2006) pp 221-237
Software Architecture amp Design Patterns
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Envisioning Architecture The Architecture Business Cycle Defining Software
Architecture Designing the Architecture Documenting the architecture Reconstructing
Software Architecture
Unit 2 Creating Architecture Quality Attributes Moving from quality to Architecture
Architectural styles and patterns Operations Achieving qualities designing the Architecture
Documenting the architecture Reconstructing Software Architecture shared information
systems
Unit 3 Analyzing Software Architecture Analyzing development qualities at the architectural
level SAAM ATAM CBAM Architecture Reviews
Unit 4 Moving from Architecture to Systems Software Product Lines Building systems from
off the shelf components Reuse of Architectural assets within an organization
Unit 5 Patterns Definition Pattern categories Pattern Description Patterns and Software
Architecture Pattern Systems Classification Selection Design Patterns Catalog Creational
Pattern Structural Pattern Behavioral Patterns Pattern Community Designing a document
editor
Unit 6 Advanced Studies Key word in Context The World Wide Web a case study in
interoperability Instrumentation software cruise control Flight Simulation -a case study in
architecture for integration
Suggested Readings-
Text Books
1 Design Patterns Elements of Reuseable Object-Oriented Software by Erich Gamma etal
Addison Wesley
2 Software Architecture in Practice 2nd Edition by Len Bass Paul Clements Rick
Kazman published by Pearson Edition
3 Design Patterns explained by Shalloway amp Tautt 2004
Reference Books
1 Pattern-Oriented Software Architecture A system of Pattern F Buschmann et al John
Wiley amp Sons 1996
Component Based Technology
Lectures - 3 Hrs per week Theory - 150 Marks
Unit 1 Component Models Functional Behavior Timing interfaces resource utilization
mobility in a component constraints
Unit 2 Component Integration Verification amp Validation Verification of component against
its specification across all viewpoints checking consistency analyzing potential interferences
between conflicting requirements formal verification testing of components integration
Unit 3 Soft Real Time including the formalization and reasoning about soft real-time and
quality of service requirements
Unit 4 Combination of hard amp soft real-time requirements
Unit 5 Intelligent Middleware Viewpoint Support amp Optimization Providing Service
supporting all viewpoints in making intelligent decisions for deployment architectures
Unit 6 Synthesis and Deployment such as knowledge based component retrieval based on
requirement specifications and Architectural Patterns
Suggested Readings-
Text Books
1 Ian Sommerville Software Engineering 7th Edition Addison-Wesley 2004ISBN 81-
7758-530-4
2 Component Software Beyond object-oriented programming Clemens Szyperski
Addison-Wesley 2002
3 UML Components A simple process for specifying component-based software (The
component software series) John Cheesman amp John Daniels Addison-Wesley 2000
Reference Books
1 Component-based Software Engineering Putting the pieces together George T
Heineman amp William T Councill Addison-Wesley 2001
2 Building J2EE Applications with the Rational Unified Process J Eeles K Houston amp
W Kozaczynski Addison-Wesley 2001
3 Roger S Pressman ldquoSoftware Engineering ndash A Practitionerrsquos Approachrdquo - 4th edition
McGraw Hill Publications