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Name : Dr. R.P.Tripathi
Date of Birth : 24.12.1956
Designation : Chief Scientist
Postal Address: Medicinal and Process Chemistry Division
CSIR- Central Drug Research Institute,
Jankipuram extn.
Lucknow-226031
Emails: [email protected] or [email protected] or [email protected]
Educational Qualifications: M.Sc. (Gorakhpur University), M.Phil, Ph. D.(Delhi University )
Degree University Year Division Field
Ph.D. Delhi University 1985 -- Organic Chemistry
M. Phil Delhi University 1982 A Grade Organic Chemistry
M.Sc. Gorakhpur University 1979 Ist Chemistry
B.Sc. Gorakhpur University 1977 Ist Biological Sciences
Positions held:
JRF UGC New Delhi 1981-1983
SRF UGC New Delhi 1983-1985
Research Associate NIH project at CDRI, Lucknow 1985-1987
Scientist B CDRI, Lucknow 1987-1992
Scientist C CDRI, Lucknow 1992-1997
Scientist E1 CDRI, Lucknow 1997-2001
Scientist EII CDRI, Lucknow 2001-2006
Scientist F, CDRI, Lucknow 2006-Till date
Membership of scientific bodies:
Life member Indian Chemical Society
Life member Indian medicinal chemists association
Life member UP association of advancement of science and technology
Life member Society of biological chemists of India
Member of Association of Carbohydrate Chemists & Technologists of India
Editorial Board Member ARKIVOC
Editorial Board Member Trends in Carbohydrate Research
Editorial Board member of Medicinal Chemistry –An Indian Journal
Associate Editor Carbohydrate News Letter
Editorial board member International Journal of Drug Design and Delivery
Reviewer for a number of International Scientific Journals and books
Member of different Selection Committees and Research Boards
Research and training Experience:
27 years research experience in different laboratories of Delhi University and Central Drug
Research Institute, Lucknow and abroad.
Countries visited: 1. France, INSA Exchange Programme, University of Rennes 1, Rennes,
France 2006
2. Pretoria, South Africa ICS-UNIDO Programme-2010
Projects Handled or in Hand: NIH USA, VW Foundation Germany, DRDO, ICMR, DBT New
Delhi
Research Specialisation:
Organic Chemistry: Oxygen and nitrogen heterocyles, Nucleosides, carbohydrates, asymmetric
synthesis, Combinatorial Chemistry,
Medicinal Chemistry: Development of antiparasitic agents(malaria, filarial, leishmania,
trypanosome), antivirals, Tuberculosis, diabetes, and antitoxicants
Ph.D. Students Supervised and Post Doc Fellow:
1. Dr. AR Khan (Ass. Professor, Integral University, Lucknow)
2. Rahul Tripathi (Joined BARC Mumbai as senior scientist in
between)
3. Dr. VK Tiwari (BHU Faculty, Chemical Sciences)
4. Dr. RC Mishra (PDF, Georgia State University)
5. Dr. Neetu Tewari ( PG teacher Govt Girls PG College
Dehradun)
6. Dr. Diksha Katiyar (BHU Faculty, MV-BHU Chemistry)
7. Dr. Shyam Sunder Verma (Research Scientist- Ranbaxy)
8. Dr. Namrata Dwivedi (Jwahar Lal Nehru PDF Fellow- NCL
Pune)
9. Dr. Nisha Saxena (Astt. Professor, Department of Chemistry,
GCET, Gr. Noida, UP
10. Dr. Biswajit Singh (Research Scientist, Jubilliant Chemsys, Gr.
Nioda)
11. Dr. Jyoti Pandey (Selected Astt Profesoor, Baba Saheb Bimrao
Ambedkar University Lucknow)
12. Dr. Surendra Singh Bisht (Scientist Chemistry of Forest Product
Division,Institute of Wood Science and Technology,Bangalore
Karnataka State, India)
13. Dr. Nimisha Singh (USA)
14. Dr. Mridul Mishra (RA at Ranbaxy Research Laboratories)
15. Dr. Sarvesh Pandey (CSIR, Res. Asso. Now working at
Gorakhpur University)
16. Mr. V.K Marya (STA, SAIF, CDRI Lucknow)
17. Mr. Amit Yadav (joined PG Govt College Hardoi, Kanpur
University in between)
18. Mr Vivek Parasar Pandey (Submitted thesis, Associate Scientist
(R & D), Sandoz Pvt. Ltd. (a Novartis company), MIDC,
Mahad, Raigad 402309, Maharastra, INDIA
19. Dr Anindra Sharma (Joining Shortly at IISc Banglore as Res.
Associate)
20. Mr. Rahul Sharma (Joined SRF at Central University, Chhatis
garh)
Present Group Members:
21. Mrs. Shashi Rastogi (STA)
22. Arya Ajay (SRF)
23. Seerat Fatima (SRF)
24. Namrata Anand (SRF)
25. Munna P. Gupt (JRF)
26. G.R.K. Ramkrishnan (JRF)
27. Mr. N. Devendar (JRF)
28. Mr Kapil Upadhyay (JRF)
29. Mr. Venkat Pasam Reddy (JRF)
Short Term/ Long Term Training:
1. Mr. Vaibhav Garg
2. Mr. P. Yakabaram
3. Miss Aparana Pandey
4. Mr. Ankur Srivastava (Torrent Pharmaceutical)
5. Miss Abha Verma
6. Mr. Beni Ram Sahu (Drug Inspector Chattisgarh)
7. Mr. Rajendra Yadav (Pharma Teacher Dehradun)
8. Pranav Gangwar (Zydus cadila Baroda)
9. Pooja Pandey (Zydus cadila Baroda)
10. Miss Priyanka Singh (IIT Kanpur, Pharma COMPANY)
11. Mr. Srijan Srivastava (Lucknow University)
12. Mr. Udai Tripathi (Selected for Zydus Cadila BARODA)
13. Mr. Waseem Shekh (NIPER Raibarrelly)
14. Miss Akansha Singh (Nanded)
15. Miss Swati Bajpayee (Lucknow University)
Honors and Awards:
1. Best paper award by Indian Pharmacological society of India on “3-Cyano-4-methyl-5-vinyl
pyridine: A potent synthetic hepatoprotective agent. P.K.S. Visen, Binduja Saraswat, G.K. Patnaik,
R.C. Srimal, R.P. Tripathi and D.S. Bhakuni. Indian J. Pharmacol. (1993), 25, 149.”
2. Best Poster award: Carbo-XX held at Lucknow University In Nov 2005
3. Most Cited paper award by Elsevier: Bioorganic & Medicinal Chemistry Most Cited Paper
2003-2006 award to RP Tripathi on “Synthesis and bioevaluation of glycosyl ureas as -glucosidase
inhibitors and their effect on Mycobacterium: Neetu Tewari, V.K. Tiwari, R.C. Mishra, R.P.
Tripathi, A.K.Srivastava, R. Ahmad, R. Srivastava and B.S.Srivastava, Bioorg. Med. Chem., 2003,
11, 2911-2922.”
4. INSA Visiting Scientist Fellowship: Visited University Rennes 1, Rennes, France 1.6.06 to
30.6.06
5. “Synthesis and antitubercular activity of 5-benzyl-3-phenyl dihydroisoxazole” Second best poster
award Euro-India First International Conference on Holistic Medicine 21.8.2008. Surendra S. Bisht,
Vivek Parashar Pandey and R. P.Tripathi.
6. Best poster award: CARBO-XXIII „08‟ held at Bhavnagar University. Poster entitled “Synthesis
of polyfunctional alkenoyl and alkanoyl C-glycosides and their α-glucosidase inhibitory activity”
presented by Surendra S. Bisht.
7. Miss Jyoti Pandey one of my Ph.D. students was selected for DST-DFG '09' award for the
participation in Noble Laureates and students meeting at Lindau, Germany based on her scientific
caliber.
8. “Excellence in Carbohydrate Research Award” First eTCR award 2009 by Association of
Crabohydrate Chemists and Technologists of India at Shimla University on 11.11.2010.
8. List of Publications: Total 128 1. Diversity oriented synthesis of pyran based polyfunctional stereogenic macrocyles and
their conformational studies, Arya Ajay, Shrikant Sharma, Vikas Bajpai, Brijesh Kumar,
Mahabir Prasad Kaushik, Ravi Sankar Ampapathi, and Rama Pati Tripathi, Organic
Letter, (2012), Manuscript under consideration.
2. Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and
2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG, Namrata Anand,
Priyanka Singh, Anindra Sharma, Sameer Tiwari, Vandana Singh, Diwakar K Singh,
Kishore K Srivastava, B. N. Singh and Rama Pati Tripathi, Bioorg. Med. Chem.,
(Accepted 2012).
3. One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines
and their bio-evaluation as anti-malarial and anti-HIV agents, Seerat Fatima, Anindra
Sharma, Reshu Saxena, Rajkamal Tripathi, Sanjeev K. Shukla, Swaroop Kumar Pandey,
Renu Tripathi and Rama P. Tripathi, Eur. J. Med. Chem., (Accepted 2012).
4. Accessing a small library of pluripotent 1,4,5-trisubstituted 1H-1,2,3-triazoles via
diversity oriented synthesis, Arya Ajay, Munna Pd. Gupt, N. Devender, Rama P. Tripathi,
Mol Divers (2012) 16:335–350.
5. Robust turn structures in alpha3beta cyclic tetrapeptides induced and controlled by
Carbo-beta3 Amino acid, Anindra Sharma, Shrikant Sharma, Rama P. Tripathi, and Ravi
Sankar Ampapathi, J. Org. Chem., 2012, 77 (4), 2001–2007.
6. Development of chemical approaches to treat tuberculosis in the last decade. R. P.
Tripathi, S. S. Bisht, A. Ajay, A. Sharma, M. Mishra, M. Pd. Gupt, Current Medicinal
Chemistry, 2012, 19, 488-517.
7. Vinod K. Tiwari, Ram C. Mishra, Anindra Sharma and Rama P. Tripathi “Carbohydrate
based Potential Chemotherapeutic Agents: Recent Developments and their Scope in
Future Drug Discovery” Mini Rev Med Chem (Article in Press).
8. Synthesis and bioevaluation of aryl hydroxamates distinguishing between NAD+ and
ATP-dependent DNA ligases, Vandna Kukshal, Mridul Mishra, Arya Ajay, Taran
Khanam, Rahul Sharma, Divya Dube, Deepti Chopra, Rama Pati Tripathi and
Ravishankar Ramachandran, Med. Chem. Commun., 2012,3, 453-461.
9. Synthesis and enzyme inhibitory activities of highly functionalized pyridylmethyl-C-β-D-
glycosidesVivek Parashar Pandey, Natasha Jaiswal, A. K. Srivastava and Rama Pati
Tripathi J. Carbohydr. Chem. 2012, 43, 14.
10. Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and
Antihyperlipidemics Journal of Enzyme Inhibition and Medicinal Chemistry 2012, 27, 2,
211-222.
11. Synthesis, molecular modeling and bio-evaluation of cycloalkyl fused 2-aminopyrimidines
as antitubercular and antidiabetic agents Nimisha Singh, Sarvesh Kumar Pandey, Namrata
Anand, Richa Dwiwedi, Shyam Singh, Sudhir Kumar Sinha, Vinita Chaturvedi, Natasa
Jaiswal, Arvind Kumar Srivastava, Priyanka Shah, M. Imran Siddiqui, Rama Pati
Tripathi, Bioorganic Medicinal Chemistry, 2011, 21, 4404-4408
12. Synthesis of dispiro-cycloalkanones, their in silico screening and bioevaluation as
antituberculosis and mycobacterial NAD+-dependent DNA ligase inhibitors Rama P.
Tripathi , Jyoti Pandey, Vandana Kukshal, Arya Ajay, Mridul Mishra, Divya Dube, Deepti
Chopra, R. Dwivedi Vinita Chaturvedi and Ravishankar Ramachandran MedChemComm
2011, 2, 378-384.
13. A simple and efficient one pot synthesis of multifunctional 5-aryl-5H-thiazolo[3,2-a]-
pyrimidines Seerat Fatima, Anindra Sharma, Rahul Sharma and R.P. Tripathi Journal of
Heterocyclic Chemistry 2011 (In press)
14. Application of butenonyl-C-glucosides in the synthesis of pyrazolinyl-,
aminopyrimidinyl- and biphenyl methyl- β-D- C-glucopyranosides Seerat Fatima, V. P.
Pandey, Rama P Tripathi, Molecular Diversity, 2011, 15, 3, 759-768.
15. Application of click chemistry towards an efficient synthesis of 1,2,3-1H-triazolyl
glycohybrids as enzyme inhibitors, N. Anand, S. K. Pandey and Rama P. Tripathi
Carbohydrate Research 2011, 346, 16-25.
16. One pot protecting group free synthesis of multifunctional biphenyl methyl-C-β-D-
glycosides in aqueous medium Mridul Mishra, Rahul Sharma, R.P. Tripathi , Tetrahedron
2011, 67, 740-748.
17. Search of antimycobacterial activities in hybrid molecules with benzopyran skeleton. Rama
P. Tripathi, Surendra Singh Bisht, Vivek Parashar Pandey, Sarvesh K. Pandey, Shubhra
Singh, Sudhir Kumar Sinha, Vinita Chaturvedi Medcicnal Chemistry Research 2011, 20, 9,
1515-1522.
18. Synthesis and bio-evaluation of alkylaminoaryl phenyl cyclopropyl methanones as
antitubercular and antimalarial agents. Arya Ajay, Vandana Singh, Shubhra Singh, Swaroop
Pandey, Sarika Gunjan, Divya Dubey, Sudhir Kumar Sinha, Bhupendra N. Singh, Vinita
Chaturvedic, Renu Tripathi, Ravishankar Ramchandran, Rama P. Tripathi, Bioorganic
Medicinal Chemistry 2010,18, 8289-8301.
19. DBU catalysed aldol reaction of D-xylofuranosyl dialdoese with acetophenones:
unprecedented ether cleavage accompanied with formation of dienones P. Gangwar, A.
Sharma and R.P. Tripathi Trends Carbohydr Res. 2010, 2, 42-45.
20. Synthesis And Optimization Of Antitubercular Activities In A Series Of 4-(Aryloxy)Phenyl
Cyclopropyl Methanols Surendra S. Bisht, Namrata Dwivedi, Vinita Chaturvedi, Namrata
Anand, Mridul Misra, Rahul Sharma, Brijesh Kumar, Richa Dwivedi, Shyam Singh, Sudhir
Kumar Sinha, Versha Gupta, P.R. Mishra, Anil K. Dwivedi and Rama P. Tripathi European
Journal of Medicinal Chemistry, 2010, 45, 1965-1978.
21. Synthesis and anti breast cancer activity of biphenyl based chalcones: Anindra Sharma,
Bandana Chakravarti, Munna Prasad Gupt, Jawed A. Siddiqui, Rituraj Konwar, Rama P.
Tripathi Bioorganic Medicinal Chemistry 2010, 18, 4711-4720
22. Regioselective [3+2] cycloaddition of chalcones with a sugar azide: easy access to 1-(5-
deoxy-D-xylofuranos-5-yl)-4,5-disubstituted-1H-1,2,3-triazoles: Nimisha Singh, S. K.
Pandey, Rama P. Tripathi Carbohydrate Res. 2010, 243, 1641-1648.
23. Synthesis and Antitubercular Activity of 5-benzyl-3-phenyl dihydroisoxazoles. S. S. Bisht,
A. Ajay, S. K. Sinha, V. Chaturvedi and Rama P. Tripathi International Journal of Drug
Design and Discovery 2010, 1,11-18.
24. Leishmania donovani: Oral therapy with glycosyl 1,4-dihydropyridine analogue showing
apoptosis like phenotypes targeting pteridine reductase 1 in intracellular amastigotes Jaspreet
Kaur , Nasib Singh , Biswajit Kumar Singh , Anuradha Dube , Rama Pati Tripathi , Prashant
Singh , Neeloo Singh Experimental Parasitology 2010, 125, 310–314
25. Synthesis and molecular docking studies of 1-phenyl-4-glycosyl-dihydropyridines as potent
antileishmanial agents. V. P. Pandey, S. S. Bisht, M. Mishra, A. Kumar,M. I. Siddiqi, Aditya
Verma, Monika Mittal, Shraddha A. Sane, Suman Gupta,Rama P. Tripathi European
Journal of Medicinal Chemistry 2010,45,2381-2388
26. Kaur Jaspreet; Singh Nasib; Singh Biswajit Kumar; Dube Anuradha; Tripathi Rama Pati;
Singh Prashant; Singh Neeloo Leishmania donovani: oral therapy with glycosyl 1,4-
dihydropyridine analogue showing apoptosis like phenotypes targeting pteridine reductase 1
in intracellular amastigotes.Experimental Parasitology 2010;125(3):310-4
27. Application of Huisgen (3+2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobnzofuran-
2-yl methyl [1,2,3]-triazoles and their Antitubercular evaluations. Rama P. Tripathi, A. K.
Yadav, S. S. Bisht, V. Chaturvedi, S. K. Sinha European Journal of Med. Chem. 2010, 45,
142-148.
28. L-Proline catalyzed multicomponent reaction of 3, 4-dihydro-(2H)-pyran,urea/thiourea, and
aldehydes: diastereoselective synthesis of hexahydropyrano pyrimidinones (thiones). J.
Pandey, .N. Anand, Rama P. Tripathi Tetrahedron 2009,65, 9350-9356
29. An orally effective dihydropyrimidone (DHPM) analogue inducesapoptosis-like cell death in
clinical isolates of Leishmania donovani overexpressing pteridine reductase 1. N. Singh , J.
Kaur , P. Kumar , S. Gupta , N. Singh ,A.Ghosal , A. Dutta , Ashutosh Kumar, RamaPati
Tripathi ,M. I. Siddiqi , C. Mandal , A. Dube Parasitology Reseach 2009
30. Synthesis of plurisubstituted furo[3,2-b] pyrans and furo[3,2-b] chromenes from D- glucose
VP Paandey, SS Bisht, RP Tripathi Trends in Carbohydr. Res. 2009, 1, 27-31.
31. BF3.OEt2 catalaysed mannosylation of phenolics with 2,3,4,5-di-O-isoprpylidene D-
mannofurnaos accompanied by selective in situ deketalization Nisha Saxena, Jyoti Pandey, .
Tamarkar, AK Srivastva and RP Tripathi, Trends in Carbohydr. Res. 2009, 1, 29-37
32. Synthetic studies in butenonyl C-glycosides: Preparation of polyfunctional alkanonyl
glycosides and their enzyme inhibitory activity. S. S. Bisht, S. Fatima, A. K. Tamrakar, N.
Rahuja, N. Jaiswal, A. K. Srivastava, Rama P. Tripathi Bioorganic & Medicinal Chemistry
Letters 2009, 19, 2699–2703.
33. An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of
aromatic aldehydes and β-keto esters or ketones. Anindra Sharma, Jyoti Pandey, R.P.
Tripathi Tetrahedron letters 2009, 50, 1812–1816.
34. Solution phase synthesis of a library of carbapeptide analogues based on glycosylamino acid
scaffolds, their in silico screening and antimicrobial evaluation. Jyoti Pandey, Anindra
Sharma, Vinod K. Tiwari, Divya Dube, Ravishankar Ramachandran, Vinita Chaturvedi,
Sudhir K. Sinha, Nripendra N. Mishra, Praveen K. Shukla, Rama P. Tripathi J. Comb.
Chem. 2009, 11, 422–427.
35. Synthesis and antitubercular screening of imidazole derivatives. V.K. Tiwari, J. Pandey, S.S.
Verma, V. Chaturvedi, S. Sinha, R.P. Tripathi European Journal of Med. Chem. 2009, 44,
3350-3355.
36. Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as
antimalarials Mridul Misra, Swaroop Kumar Pandey, Vivek Parashar Pandey, Jyoti Pandey,
Renu Tripathi, Rama Pati Tripathi Bioorganic Medicinal Chemistry, 2009, 17, 625-633.
37. L-Ascorbic Acid in organic Synthesis- Tripathi, R.P., Biswajit Singh, S.S. Bisht,; J. Pandey,
Current Organic Chemistry 2009, 13, 99-122.
38. Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents
B.K. Singh , Mridul Mishra , Nisha Saxena , G.P. Yadav , P.R. Maulik ,M.K. Sahoo , R.L.
Gaur, P.K. Murthy , R.P. Tripathi, European Journal of Medicinal Chemistry 2008, 43,
2717-2723
39. Pharmacokinetics and excretion of the novel anti-tuberculosis compound 1,2 : 5,6-di-O-
isopropylidene-3-O-(phenyl cyclopropyl methanonyl)-alpha-D-glucofuranose (S-001-14)
after oral doses in rats Lal J, Tripathi R.P., Gupta RC, Arzneimittel-Forschung-Drug
Research 2008, 58, 410-418.
40. Recent Development on catalytic reductive amination and applications Tripathi R. P.,
Verma S. S., Pandey J., V. K. Tiwari Current Organic Chemistry 2008, 12, 1093-1115.
41. Leishmania donovani pteridine reductase 1: Biochemical properties and structure- modelling
studies Kumar P, Kumar A, Verma SS, Dwivedi N., Siddiqui, I., Dube , A; Tripathi, R.P. ;
Singh, N. Experimental Parasitology 2008, 120, 73-79.
42. Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial
evaluation N Saxena; N Singh; M. Mishra; G. B. Shiva Keshava; P. K. Shukla; Rama Pati
Tripathi. Journal Of Enzyme Inhibition And Medicinal Chemistry 2008, 23, 476-482.
43. Synthesis and antitubercular activity of nucleoside analogs based on L-ascorbic acid and
bases Author(s): Tripathi R.P., Dwivedi N, Singh N, Mridul Mishra. MEDICINAL
CHEMISTRY Research 2008, 17, 53-61.
44. NAD(+)-dependent DNA ligase (Rv3014c) from M-tuberculosis: Strategies for inhibitor
design Dube D, Kukshal V, Srivastava SK, R.P. Tripathi and R. Ramachandran Medicinal
Chemistry Research 2008, 17, 189-198.
45. Aldol reaction of beta-C-glycosylic ketones: synthesis of C-(E)-cinnamoyl glycosylic
compounds as precursors for new biologically active C-glycosides Bisht SS, Pandey J,
Sharma A, Tripathi, R.P. Carbohydrate Research 2008, 343, 1399-1406.
46. NAD(+)-dependent DNA ligase: A novel target waiting for the right inhibitor. Dwivedi N,
Dube D, Pandey J, Singh BK, Ramchandran R., Tripathi R.P. Medicinal Research Reviews
2008, 28, 545-568.
47. Preparation and reactions of sugar azides with alkynes: synthesis of sugar triazoles as
antitubercular agents Singh BK, Yadav AK, Kumar B, Gaikwad, A.N.; Sinha, S.K.,
Chaturvedi V. and Tripathi R.P. Carbohydrate Research 2008 , 343, 1153-1162.
48. Evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting
molecules active against multi-drug resistant Mycobacterium tuberculosis. Chaturvedi V,
Dwivedi N, Tripathi R.P., Sudhir Sinha Journal Of General And Applied Microbiology
2007, 53, 333-337.
49. D-Glucosamine, a natural aminosugar as organocatalyst for an ecofriendly direct aldol
reaction of ketones with aromatic aldehydes in water. Singh N, Pandey J, Tripathi R.P.
Catalysis Communications 2008, 9 743-746.
50. An efficient chemoselective etherification of phenols in polyfunctional aromatic compounds
Pandey J, Mishra M, Bisht SS, Sharma A. and Tripathi R.P. Tetrahedron Letters 2008, 49,
695-698
51. One-pot Amberlite IR-120 catalysed synthesis of glycosyl dihydropyridones. Tiwari VK,
Tewari N, Katiyar D, Tripathi R.P. Monatshefte Fur Chemie 2007, 138, 1297-1302
52. An elegant and unprecedented approach to 2-methylbenzofurans. Yadav AK, Singh BK,
Singh N, Tripathi R.P. Tetrahedron Letters 2007, 48, 6628-6632
53. Synthesis and biological evaluation of potential modulators of malarial Glutathione-S-
transferase(s). R. Ahmad, A. K. Srivastava, R. P. Tripathi, S. Batra and R. D. Walter J.
Journal of Enzyme Inhibition and Medicinal Chemistry, June 2007; 22(3): 327–342
54. L-Ascorbic acid in organic synthesis: a facile synthesis of 4-(butenolide-5-methylidenyl)-
1,4-dihydropyridines. S. S. Bisht, N. Dwivedi, R. P. Tripathi Tetrahedron Lett., 2007, 48,
1187.
55. Diastereoselective synthesis of glycosylated prolines as alpha-glucosidase inhibitors and
organocatalyst in asymmetric aldol reaction. J. Pandey, N. Dwivedi, N. Singh, A. K.
Srivastava, A. Tamarkar and R. P. Tripathi Bioorganic & Med. Chem. Letters, 2007, 17,
1321.
56. An elegant and unprecedented approach to 2-methyl benzofurans. A. K. Yadav, B. K. Singh,
N. Singh, R. P. Tripathi Tetrahedron Lett, 2007, 48, 6628-6632.
57. Novel specific inhibitors of NAD +-dependent DNA ligase (RV3014C) from M.
tuberculosis identified from virtual screening Dube, D., Srivastava, S.K., Kukshal, V.,
Tripathi, R.P., Ramachandran, R. 2006 Medicinal Chemistry Research 15 (1-6) , pp. 93-
94
58. L-ascorbic acid in organic synthesis: DBU-catalysed one-pot synthesis of tetramic acid
derivatives from 5,6-O-isopropylidene ascorbic acid. B. K. Singh, S. S. Verma, N. Dwivedi,
R. P. Triapthi Tetrahedron Letters, 2006, 47, 2219.
59. DBU assisted expeditious synthesis of glycosyl dienes via glycosylated beta-hydroxy esters.
S. S. Verma, N. Dwivedi, B. K. Singh, R. P. Tripathi Carbohydr. Res, 2006, 341, 1930.
60. Search of antitubercular activities in tetrahydroacridines: Synthesis and biological evaluation.
R. P. Tripathi, S. S. Verma, J. Pandey, K.C. Agarwal, V. Chaturvedi, Y.K. Manju, A. K.
Srivastva, A. Gaikwad, S. Sinha Biorganic & Med.Chem.Lett., 2006, 16, 5144.
61. Recent developments in search of antifilarial agents. R. P. Tripathi, D. Katiyar, N. Dwivedi,
B. K. Singh, J. Pandey Curr.Med. Chem., 2006, 13, 3319.
62. Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines.
R. P. Tripathi, N. Saxena, V. K. Tiwari, S. S. Verma, V. Chaturvedi, Y. K. Manju, A. K.
Srivastva, A. Gaikwad and S. Sinha Biorganic & Med. Chem., 2006, 14, 8186.
63. Asymmetric organocatalysis with glycosyl-beta-amino acids: direct asymmetric aldol
reaction of acetone with aldehydes. N. Dwivedi, S. S. Bisht, R. P. Tripathi Carbohydr. Res.,
2006, 341, 2737.
64. An efficient synthesis of tetramic acid derivatives with extended conjugation from L-
Ascorbic acid. B. K. Singh, S. S. Bisht, R. P. Tripathi Beilstein J. Org. Chem., 2006, Art.
No. 24,
65. Fighting Tuberculosis: An old disease with new challenges R. P. Tripathi, N. Tewari, N.
dwivedi, V. K. Tiwari Medicinal Res. Review, 2005, 25, 93.
66. Search of new prototypes for chemotherapy of filariasis: Chemotherapeutic and biochemical
approach. S. Misra-Bhattacharya, P. Bajpai, S. K. Verma, D. Katiyar, N. Tewari, R. P.
Tripathi, I. Bansal, J. K. Saxena. Journal of Parasitology Research, 2005, 95, 383.
67. Synthesis and DNA topoisomerase-II inhibitory activity of unnatural nucleosides. R. C.
Mishra, N. Dwivedi, I. Bansal, J. K. Saxena, R. P. Tripathi Nucleosides, Nucleotides and
Nucleic Acids, 2005, 24, 15.
68. Tetrabutylammonium Hydrogensulphate Catalysed Efficient Synthesis of Glycosyl(aryl)
Dihydropyrimidinones. N. Dwivedi, R. C. Mishra and R. P.Tripathi Lett. Org. Chem., 2005,
2, 450.
69. Synthesis and Antimycobacterial Activities of Glycosylated Amines and Amino Alcohols D.
Katiyar, V. K. Tiwari, N. Tewari, S. S. Verma, S. Sinha, A. Gaikwad, A. K. Srivastava, V.
Chaturvedi, R. Srivastava, B. S. Srivastava, R.P. Tripathi Eur. J. Med. Chem., 2005, 40,
351.
70. Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by
glycosylamines compared with human ligase I. S.K. Srivastava, D. Dube, N. Tewari, N.
Dwivedi, R. P. Tripathi, R. Ramchandran Nucleic Acid Research 2005, 33, 7090.
71. NAD+-dependent ligase (Rv3014c) from M.tuberculosis H37Rv: crystal structure of the
adenylation domain and identification of novel inhibitors. S.K Srivastava, R.P Tripathi,
R.Ramachandran J. Biol. Chem., 2005, 280, 30273.
72. Current status of malaria control. R. P. Tripathi, R. C. Mishra, N. Dwivedi, N. Tewari, S. S.
Verma Curr Med Chem., 2005, 12, 2643.
73. An efficient synthesis of aryloxyphenyl cyclopropyl methanones: a new class of anti-
mycobacterial agents. N. Dwivedi, N. Tewari, V. K. Tiwari, V. Chaturvedi, Y. K. Manju, A.
K. Srivastava, A. Gaikwad, S. Sinha, R. P. Tripathi Bioorg Med Chem Lett., 2005, 15, 4526-
30.
74. Synthesis and antitubercular activities of bis-glycosylated diamino alcohols. R. P. Tripathi,
V. K. Tiwari, N. Tewari, D. Katiyar, N. Saxena, S. Sinha, A. Gaikwad, A. K. Srivastava, V.
Chaturvedi, Y. K. Manju, R. Srivastava, B. S. Srivastava. Bioorg Med Chem., 2005, 13,
5668.
75. Search for new prototypes for the chemotherapy of filariasis: a chemotherapeutic and
biochemical approach. P. Bajpai, S. K. Verma, D. Katiyar, N. Tewari, R. P. Tripathi, I.
Bansal, J. K. Saxena, S. Misra-Bhattacharya Parasitol Res., 2005, 95,383.
76. Reductive amination of glycosyl aldoses: Synthesis of N-glycosylated -glycosyl amino
alcohols and their antidiabetic potential. S. S. Verma, R. C. Mishra, A. K. Tamrakar, B. K.
Tripathi, A. K. Srivastava, R. P. Tripathi. J. Carbohydr. Chem., 2004, 23, 493.
77. 4-Methyl-7- (tetradecanoyl)-2H-1-benzopyran-2-one: A novel DNA topoisomerase II
inhibitor with adulticidal and embryo static activity against sub periodic Brugia malayi. S.
Misra-Bhattacharya, D. Katiyar, R. P. Tripathi, J. K. Saxena Parasitology Research, 2004,
92, 177.
78. A versatile synthesis of Dihydropyrimidinone C-nucleosides. R. C. Mishra, D. Katiyar, N.
Tewari, R. P. Tripathi, Nucleosides, Nucleotides and nucleic Acid, 2004, 23, 531.
79. Diastereoselective Synthesis of Galactopyranosyl Amino Esters and their Transformations
into C-nucleosides, D. Katiyar, R. C. Mishra, R. P. Tripathi, Journal of Carbohydrate
Chemistry, 2004, 23, 49.
80. Search for new antitubercular agents: SPOS of Glycoconjugates on Sieber Amide resin, R. P.
Tripathi, R. C. Mishra, D. Katiyar, K. K. Srivastava, R. Srivastava, B. S. Srivastava Ind. J.
Chem, 2004.
81. Synthesis of Galactopyranosyl Amino Alcohols as a new class of antitubercular and
antifungal agents. N. Tewari, V. K. Tiwari, R. P. Tripathi, A. Gaikwad, S. Sinha, P. K.
Shukla, R. Srivastava and B. S. Srivastava, Bio. Med. Chem.Lett., 2004, 12, 329.
82. An efficient syntheses of α-mannosylated phenolics as -glycosidase inhibitors. A. R. Khan,
V. K. Tiwari, A. K. Srivastava, R. P. Tripathi J. Enzyme Inhibition 2004, 19, 107.
83. Potential Inhibitors of DNA topoisomerase-II: ruthenium (II) poly-pyridyl and pyridyl-azine
complexes. M. Chandra, A. N. Sahai, D. S. Pandey, R. P. Tripathi, J. K. Saxena, V.J.M.
Reddy, M. Carmen Peutra, Pedro Valerga J. Organometallic Chemistry 2004, 689, 2256.
84. 1,3 Dipolar Cycloaddition of Glycosyl Nitrile Oxides with Alkenes: Diastereoselective
Synthesis of Glycosyl Isoxazolines. R.C. Mishra, N. Tewari, S. S. Verma and R. P. Tripathi
, J. Carbohydr. Chem. 2004, 23, 353.
85. Phenylene bridged bis -glycosyl ureides as potential antileishmanial agents. N. Tewari,
Ramesh, R. C. Mishra, S. Gupta, R. P. Tripathi, Bioorg. Med. Chem.Lett. 2004, 14, 4055.
86. Tetrabutylammonium Hydrogen Sulphate Catalysed Eco-friendly and Efficient Synthesis of
Glycosyl 1,4-Dihydropyridines. N. Tewari, N. Dwivedi, R. P. Tripathi Tetrahedron Lett.,
2004 , 45, 9011.
87. Solid phase synthesis of cyclopropyl phenyl methanones, R. K. Grover, R. C. Mishra, B.
Kundu, R. P.Tripathi R. Roy. Tetrahedron Lett. 2004, 45, 7331.
88. Glutathione synthesis in filarial worms: an attractive target for the design and synthesis of
new antifilarials. K. Arora, R. C. Mishra, R. P. Tripathi, A. K.Srivastava, Rolf D. Walter.
Med. Chem Res., 2004, 13, 687.
89. 7-O-(4-methyl piperazin-acetyl)-4-methyl-2H-1-benzopyran-2-ones: A novel lead compound
for antifilarial activity. R. P. Tripathi, V. K. Tiwari, S. Bhattacharya, K. Srivastava, V. M.
L. Srivastava and K. Murty Acta Tropica, 2003, 87, 215.
90. DBU Assisted Cyclorelease Elimination: Combinatorial Synthesis and -glutamyl cystein
synthetase & glutathione-S- transeferase Modulatory Activity of C- nucleoside anlogs. R. C.
Mishra, N. Tewari, K. Arora, R. Ahmad, R. P. Tripathi, V. K. Tiwari, R. D. Walter , A. K.
Srivastava Combi Chem & Highthroughtput Screening, 2003, 6, 37.
91. Synthesis and Antifilarial Evaluation of N1, Nn- Diglycosylated Diaminoalkanes. V. K.
Tiwari, N. Tewari, D. Katiyar, R. P. Tripathi, K. Arora, S. Gupta, A. K Srivastava, M. A.
Khan, P. K. Murthy Bio-Org. & Med. Chem., 2003, 11, 1789.
92. Synthesis and antifilarial evaluation of 7-O-acetamidyl-4-alkyl-2H-1-benzopyran-2-ones. D.
katiyar, V. K.Tiwari, R. P.Tripathi, V. J. M. Reddy, S. Bhattacharya, J. K.Saxena Arzn.
Forsch/Drug Research, 2003, 53, 857.
93. Synthesis and bioevaluation of glycosyl ureas as -glucosidase inhibitors and their effect on
Mycobacterium. N. Tewari, V. K. Tiwari, R. C. Mishra, R. P. Tripathi, A. K.Srivastava, R.
Ahmad, R. Srivastava, B. S. Srivastava Bioorg. Med. Chem., 2003, 11, 2911.
94. Amberlite IR -120 Catalysed Efficient Synthesis of Glycosyl Enaminones and their
Application. N. Tewari, D. Katiyar, V. K. Tiwari and R. P. Tripathi Tetrahedron Lett., 2003,
44, 6639.
95. Synthesis and Antimycobacterial Activity of 3,5-Disubstituted Thiadiazine thiones. D.
Katiyar, V. K. Tiwari, R. P. Tripathi, A. K. Srivastava, V. Chaturvedi, R. Srivastava and B.
S. Srivastava Bio. Med. Chem., 2003, 11, 4369.
96. Synthesis of Glycosylated β-Amino Hydroxamates as New Class of Antimalarials. R.
C.Mishra, R. Tripathi, D. Katiyar, N. Tewari, D. Singh, and R. P.Tripathi Bio. Med. Chem.,
2003, 11, 5363.
97. Combinatorial and conventional synthesis of glycohybrid molecules as new class of
antitubercular agents V. K. Tiwari, R. P Tripathi, V. Chaturvedi, A. Srivastava, S. Sinha, R.
Srivastava, B. S. Srivastava Medicinal Chem Res., 2003, 12, 394.
98. Synthesis of Glycosylated -amino acids as new class of antitubercular agents. R. P. Tripathi,
R. Tripathi, V. K. Tiwari, Laxmi Bala, S. Sinha, A. Srivastava, R. Srivastava, B. S.
Srivastava Eur. J. Med. Chem., 2002, 37, 773.
99. Unexpected Isomerisation of Double bond with DBU: A Convenient Synthesis of
Tetrasubstituted -alkylidene tetrahydrofuranoses. V. K. Tiwari, R. P. Tripathi Indian J.
Chem, 2002, 41B, 1681.
100. Conjugate Addition of Amines to Sugar Derived Olefinic Ester: Synthesis of Glycosylated
Amino Esters as DNA Topoisomerase –II Inhibitors. A. R. Khan, R. P. Tripathi, V. K.Tiwari,
R. C. Mishra, V. J. M. Reddy and J. K. Saxena, J. Carbohydrate Chemistry, 2002, 21, 591.
101. DBU/ TBAB/4A0 Catalysed cyclatic amidation reactions: A highly efficient & convenient
synthesis of C-Nucleosides. N. Tewari, R. C. Mishra, V. K. Tiwari, R. P. Tripathi, Synlett,
2002, 11, 1779.
102. Synthesis and immunomodulatory activities of 2'-hydroxy-3'-N, N-Disubstituted
aminopropyl-α-D-glucofuranoses as immunomodulators. A. R. Khan, R. P. Tripathi, A. P.
Bhaduri, R. Sahai, A. Puri, L. M. Tripathi, V. M .L Srivastava, Eur. J. Med. Chem, 2001, 36,
103.
103. Identification of inhibitors of DNA Topoisomerase-II from a synthetic library of
glycoconjugates. R. P. Tripathi, S. K. Rastogi, B. Kundu, J. .K. Saxena, V. J. M. Reddy, S.
Srivastava, S. Chandra, and A.P. Bhaduri Combi. Chem. & Highthroughput Screen., 2001, 4,
237.
104. Study on the loading and reactions of naked sugars on solid phase. R. C. Mishra, R. P.
Tripathi Medicinal Chemistry Research, 2001, 10, 548.
105. Glycosyl amino acid derivatives as inhibitors of yeast DNA topoisomerase. I. P. Jain, Z. K.
Khan, R. P.Tripathi, B. L. Tekwani Abstract of the symposium CTTDDR published in
Medicinal Chemistry Research, 2001, 10, 550.
106. Synthesis and antiviral activity of 3-O-(2'-hydroxy aminopropyl)- α -D-glucofuranoses. N. S.
Rana, P. Gupta, R. P. Tripathi, A. P. Bhaduri Acta Pharmaceutica, 2001, 1, 63.
107. Antifilarial activity of 2H-1-Benzopyran-2-ones (coumarins). R. P. Tripathi, R. Tripathi, S.
N. Singh, A. P. Bhaduri, R. K. Chaterjee and K. Murthy Acta Tropica, 2000, 76, 101.
108. α-Cyano ethyl propenoates: a new class of antileishmanial agents. S. Tewari, R. P. Tripathi,
A. R. Khan, S. Gupta, J. C. Katiyar, A. P. Bhaduri Arzen Forsch/ Drug Res., 1999, 49, 144.
109. DNA Topoisomerases of filarial parasites:Effect of antifilarial compounds. U. Pandya, J. K.
Saxena, S. M. Kaul, P. K. Murthy, R. K. Chatterjee, R .P. Tripathi, A. P. Bhaduri, O. P.
Shukla Medical Science Res., 1999, 27, 103.
110. Hepatoprotection by 3-cyano-5-ethenyl-4-methyl pyidine (compound 89/62) against
experimentally induced liver injury in rats. S. Srivastava, S. C. Tripathi, A. K. Srivastava, D.
S. Bhakuni, R. P. Tripathi and G. K. Patnaik Acta Pharmaceutica, 1997, 47, 117.
111. Cabohydrates in biological recognition. A. R. Khan, R. P. Tripathi, A. P. Bhaduri, Biol.
Memoirs., 1997, 23, 73.
112. Synthesis of 2,3-anhydronucleosides of pyrazolo(3,4-d) pyrimidine as antiviral agents. R.
P.Tripathi, Anil Mishra, Ram Pratap, D. S. Bhakuni Indian J. Chem., 1996, 35B, 441.
113. Asymmetric induction in the epoxidation of 3-and 5-O-allyl glycofuranoses with mCPBA.
A.R. Khan. R. P. Tripathi, A. P. Bhaduri Indian J. Chem. 1996, 35B, 405.
114. Synthesis and spermicidal activities of dithiocarbamates. R. P. Tripathi, A. R. Khan, B. S.
Shetty and A. P. Bhaduri Acta Pharmaceutica, 1996, 46, 169.
115. Effect of 3-O- (aminoalkyl)- -D-gluco (xylo) furanoses on glutathione metabolism of falarial
parasites. A. K. Srivastava, R. P. Tripathi, A. R. Khan, A. P. Bhaduri, S. N. Singh, R. K.
Chatterjee Helminthologia, 1995, 32, 25.
116. Synthesis and antiviral activities of 3-O-(aminoalkyl)-1,2-O-isopropylidene-α-D-gluco-
(xylo)furanoses, R. P.Tripathi, V. Singh, A. R. Khan , A. P. Bhaduri, G. Saxena, K. Chandra
Indian J Chem., 1995, 34B, 791.
117. Glutathione-S-transferase activity in S. cervi females and effect of new antifailarial
compounds. A. K. Srivastava, R. P. Tripathi, A. R. Khan, A. P. Bhaduri, S. N.Singh, R. K.
Chatterjee Indian J. Parasitology, 1994, 46, 169
118. 3-Cyano-4-methyl-5-vinyl pyridine: A potent synthetic hepatoprotective agent. P.K.S. Visen,
Binduja Saraswat, G. K. Patnaik, R. C. Srimal, R. P. Tripathi, D. S. Bhakuni. Indian J.
Pharmacol., 1993, 25, 149.
119. 3-Cyano-4-methyl-5-vinyl pyridine: A potent synthetic hepatoprotective agent. P.K.S. Visen,
Binduja Saraswat, G. K. Patnaik, R. C. Srimal, R. P. Tripathi, D. S. Bhakuni. Indian J.
Pharmacol., 1993, 25, 149.
120. Synthesis of 1/2-benzyl-4,6-disubstituted –1H/2H-pyrazolo(3,4-d)-pyrimidines and their
antileishmanial activities. A. Mishra, L. M. Ojha, R. P. Tripathi, R. Pratap, D. S. Bhakuni.
Indian J. Heterocyclic Chem., 1991, 1, 51.
121. Studies in nucleosides: PartXX: Synthesis and antileishmanial activities of 4-oxo-(5H)-
pyrazolo{3,4-d] pyrimidine- & -nucleosides. A. Hasan, R. P. Tripathi, Ram Pratap, D. S.
Bhakuni Indian J. Chem., 1989, 28B, 403.
122. Studies in nucleosides: PartXIX: Synthesdis of 4,6-disubstituted derivatives of 1--D-
arabinofuranosylpyrazolo{3,4-d] pyrimidines and their antiviral activities. R. P. Tripathi,
Ram Pratap, D. S. Bhakuni Indian J. Chem., 1987, 26B, 1054.
123. Studies in nucleosides: PartXVII: Synthesis of 4-amino-6-methoxy pyrazolo{3,4-d]
pyrimidine and 4-amino-6-methylthio pyrazolo[3,4-d]pyrimidine ribosides and their antiviral
activities. R. P. Tripathi, A. Hasan, Ram Pratap, D. S. Bhakuni Indian J. Chem., 1987, 26B,
851.
124. A novel synthesis of 4-propyl –2H-1-benzopyran-2-ones. V. K. Ahluwalia, R. P. Singh, R.
P. Tripathi Montash fur chemie, 1984, 115, 765.
125. An efficient synthesis of 4-propylpyranocoumarins. V. K. Ahluwalia, R. P. Singh, R. P.
Tripathi Gazzeta Chimica. Italiana, 1984, 114, 505.
126. An elegant synthesis of 6-butyryl chromans and chromenes. V. K. Ahluwalia, R. P. Singh,
R. P. Tripathi Gazzeta Chimica. Italiana,1984, 114, 359.
127. A facile synthesis of 4-propyl psoralen and angellicine derivatives. V.K. Ahluwalia, R. P.
Tripathi J. Indian Chem Soc., 1984, LXI, 1023.
128. A convenient synthesis of propyl substituted benzofuro coumarins. V. K. Ahluwalia, R. P.
Singh, R. P. Tripathi Heterocycles, 1984, 22, 2783.
List of Patents filed or in process:
1. A process for the synthesis of & - isomers of 6-amino-4-oxo-(5H)- pyrazolo{3,4-d] pyrimidine- &
-nucleosides. Patent in India No. 173563
2. A novel combinatorial library of 3-substituted amino-3-glycosylated propanoates useful as
antifungal and antibacterial agents. Rama Pati Tripathi, Praveen Kumar Shukla, Sudhir Sinha,
Ranjana Srivastava, Kishor Kumar Srivastava, Vinita Chaturvedi, Anil Srivastava, Brahm Shankar
Srivastava. 0716DEL2004 Filing date 4/15/04
3. A process for the preparation of novel combinatorial library of 3-substituted amino-3-glycosylated
propanoates useful as antifungal and antibacterial agents. Rama Pati Tripathi, Bijoy Kundu,
Praveen Kumar Shukla, Sudhir Sinha, Ranjana Srivastava, Kishor Kumar Srivastava, Vinita
Chaturvedi, Anil Srivastava, Brahm Shankar Srivastava. (NF / 315 / 01)
4. A process for the preparation of novel combinatorial library of 3-substituted amino-3-glycosylated
propanamides useful as antifungal and antibacterial agents. Rama Pati Tripathi, Bijoy Kundu,
Praveen Kumar Shukla, Sudhir Sinha, Ranjana Srivastava, Kishor Kumar Srivastava, Vinita
Chaturvedi, Anil Srivastava, Brahm Shankar Srivastava. Patent Appl. No.: 1272DEL2001 Filing
Date: 24/12/2001 Patent No.: 194984 Grant Date: 17/03/2006
5. A novel combinatorial library of 3-substituted amino-3-glycosylated propanamides useful as
antifungal and antibacterial agents. Rama Pati Tripathi, Praveen Kumar Shukla, Sudhir Sinha,
Ranjana Srivastava, Kishor Kumar Srivastava, Vinita Chaturvedi, Anil Srivastava, Brahm Shankar
Srivastava. 1529DEL2004 Filing Date 8/17/04 Patent No.: 196956 Grant Date: 23/06/2006
6. A process for the preparation of novel N1, Nn-diglycosylated diamino alkanes useful as inhibitors
of parasitic enzymes. Rama Pati Tripathi, Vinod Kumar Tiwari, Arvind Kumar Srivastava, Kavita
Arora, Sapana Gupta, K.P. Murthy, R. D. Walter. (INF/PAT/05/2001)
7. A process for the preparation of novel 4-alkyl-7-O-(acetamid-2-yl)-2H-1-benzopyran-2-ones
useful as inhibitors of helminthic and protozoan DNA topoisomerases. Rama Pati Tripathi, Jitendra
Kumar Saxena, Onkar Prasad Shukla, Subhash Chandra, Puvada Kalpana Murthy, Shailija
Bhattacharya, Kamal Kamboj, Anil Kumar Dwivedi, Ranjeet Kumar Chatterjee, Satyawan Singh,
Vishwa Mohan Lal Srivastava, Anil Kumar Rastogi, Amiya Prasad Bhaduri. 620/DEL/01
8. N1, Nn-diglycosylated diamino alkanes useful as inhibitors of parasitic enzymes) Rama Pati
Tripathi, Vinod Kumar Tiwari, Arvind Kumar Srivastava, Kavita Arora, Sapana Gupta, P. K.
Murthy, R. D. Walter. (INF/PAT/06/2001)
9. A process for the preparation of novel combinatorial library of N1 – glycosylated and N3 -
substituted ureas and thioureas useful as antitubercular agents, Rama Pati Tripathi, Vinod Kumar
Tiwari, Ram Chandra Mishra, Ranjana Srivastava, Sudhir Sriwastava, Vinita Chaturvedi, Kishor
Kumar Srivastava, Brahm Shankar Srivastava 264 DEL2002 Filing Date/ 20.03.2002
10. Novel combinatorial library of N1 – glycosylated and N3 –substituted ureas Useful as
antitubercular agents, Rama Pati Tripathi, Vinod Kumar Tiwari, Ram Chandra Mishra, Ranjana
Srivastava, Sudhir Sriwastava, Vinita Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar
Srivastava. 0715DEL2004 4/15/04 Patent Number(s): IN200400715-I1
11. Diglycosylated diaminoalcohol as novel antitubercular agents, Rama Pati Tripathi, Vinod
Kumar Tiwari, Neetu tewari, Ranjana Srivastava, Sudhir Srivastava, Vinita Chaturvedi, Kishor
Kumar Srivastava, Brahm Shankar Srivastava. 999/DEL/30.09.2002.
12. A process for the preparation of diglycosylated diaminoalcohol as antitubercular agents Rama
Pati Tripathi, Vinod Kumar Tiwari, Neetu tewari, Ranjana Srivastava, Sudhir Srivastava, Vinita
Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava (998/DEL/30.09.2002)
13. Novel Galactopyranosylated aminoalcohols useful in chemotherapy of tubercular infections;
Rama Pati Tripathi, Neetu Tewari, Ram Chandra Mishra, Ranjana Srivastava, Sudhir Sinha, Anil
Srivastava, Vinita Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava 1212DEL2004
Filing Date 6/30.2004
14. A process for the preparation of Galactopyranosylated aminoalcohols useful in chemotherapy of
tubercular infections, Rama Pati Tripathi, Neetu tewari, Ram Chandra Mishra, Ranjana Srivastava,
Sudhir Sinha, Anil Srivastava, Vinita Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar
Srivastava 1609DEL2004 Filing Date 8/26/04
15. Novel 1,3,5-thiazidine -2-thiones useful in chemotherapy of tubercular infections, Rama Pati
Tripathi, Diksha Katiyar, Ranjana Srivastava, Anil Srivastava, Vinita Chaturvedi, Kishor Kumar
Srivastava, Brahm Shankar Srivastava 1098DEL2004 Filing Date 6/11/2004
16. A process for the preparation of 1,3,5-thiazidine -2-thiones useful in chemotherapy of tubercular
infections, Rama Pati Tripathi, Diksha Katiyar, Ranjana Srivastava, Anil Srivastava, Vinita
Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava, 1098DEL2004 Filing Date
6/11/04
17. Novel Phenyl Cyclopropyl methanones useful as antitubercular agents, Rajesh Grover, R.C.
Mishra, S.S. Verma, R.P. Tripathi, Raja Roy, A.K. Dwivedi, S.Singh, Ranjana Srivastava, Anil
Srivastava, Vinita Chaturvedi, Manju Y. Krishnan , Brahm Shankar Srivastava 0636DEL2004 Filing
Date 3/31/2004
18. A process for the preparation of novel glycosylated aminoalcohols useful in the treatment of
tuberculosis Ramapati Tripathi, Vinod Kumar Tiwari, Neetu Tewari, Diksha Katiyar, Anil Kumar
Dwivedi, Styawan Singh, Anil Gaikwad, Sudhir Sinha, Ranjana Srivastava, Sudhir Srivastava, Vinita
Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava 1217DEL/04 30.6.04
19. Novel Dispiro cyclalkanones useful as inhibitors of NAD+-dependent DNA Ligase and
antitubercular agents Rama Pati Tripathi, Jyoti Pandey, Nimisha Singh, Divya Dube, Vandna
Kukshal, Shalini Bhatnagar, Sudhir Sinha, Vinita Chaturvedi, Ravishankar Ramchandran
0082DEL2010 Dated 29.01.10
20. An Antitubercular formulation of 4-alkoxy phenyl cyclopropyl methanes Rama Pati Tripathi,
Prabhat Ranjan Mishra, Girish Kumar Gupta, Surendra Singh Bisht, Jyoti Pandey, Vinita Chaturvedi,
Sudhir Sinha, Versa Gupta and Anil Kumar Dwivedi 0183DEL2010 FILED ON 29.01.10
Chapters in Book: 1. Synthesis and antifilarial evaluation of a few carbohydrate derivatives.
R.P.Tripathi, V.Singh, A.R.Khan, A.P.Bhaduri, S.Bhatnagar and A.K. Srivastava. “Trends in
Carbohydrate Chemistry,” edited by P.L.Soni, Surya International Publication, Dehradune pp 1-4
(1995).
2. Search of new drugs for tuberculosis: Glycosylated -amino acids as new class of antitubercular
agents, Trends in Carbohydrate Chemistry, Vol-8 (in press), and Published by Surya international
publication, Dehradun. Authors: V.K.Tiwari, R. P. Tripathi, R. Tripathi, Laxmi Bala, S. Sinha, A.
Srivastava, R. Srivastava, B.S. Srivastava.
Paper Presented in conference: (Last three years)
1. Identification of inhibitors of DNA Topoisomerase II from a synthetic library of glycopeptides, R.
P. Tripathi, S. K. Rastogi, B. Kundu, J.K. Saxena, S. Srivastava, V.J.M. Reddy, S. Chandra, A. P.
Bhaduri, Fifth IUPAC International Symposium on Bio-Organic Chemistry, ISBOC-5, at National
Chemical Laboratory- Pune, 3rd Jan - 4 th Feb 2001.
2. Unexpected Isomerisation reaction with DBU: An easy access to -alkylidene tetrahydrofuranose,
V. K. Tiwari, R. P. Tripathi, Current Trends in Drug Discovery Research, 11-15 Feb 2001 at CDRI
Lucknow.
3. Antifilarial profile of a novel lead compound: 7-O- (4-methyl piperazin-acetyl)-4-methyl 2H-1-
benzopyran-2-ones, R. P. Tripathi, V. K. Tiwari, S. Bhattacharya, K. Srivastava, V. M. L.
Srivastava and K. Murty, Indian Conference of Parasitology, 1-3 Oct 2001 at Jodhpur.
4. Synthesis of glycosylated amino esters as DNA topoisomerase-II inhibitors A.R.Khan, R. P.
Tripathi, V. K. Tiwari, R. C. Mishra, V. J. M.Reddy and J. K. Saxena, National Biorganic
Symposium 7, GNDU Amritsar 7-9 Nov 2001
5. Depletion of intracellular Glutathione of Setaria cervi by Dimethylmaleate, Phorone and
Aminoalkane derivatives. S. Gupta,V. K. Tiwari, R. P. Tripathi, A. K. Sriwastava, Indian
Conference of Parasitology, 1-3 Oct 2001 at Jodhpur.
6. Glycosylated -amino acids as new class of antitubercular agents. V. K. Tiwari, R. P. Tripathi, R.
Tripathi, Laxmi Bala, S. Sinha, A. Srivastava, R. Srivastava, B. S. Srivastava, 16th Carbohydrate
Conference,6-7 December at Trivendrum.
7. Conjugate Addition of Hydrazine and Hydroxyl Amines to Sugar derived Olefinic Esters:
Synthesis of glycosylated heterocycles. R. C. Mishra, N. Tewari, R. P. Tripathi, 22-24 Feb Alembic
Ltd Vadodara.
8. Synthesis and bioevaluation of glycosyl ureas as -glucosidase inhibitors and antituberculosis
agents. V. K. Tiwari, N. Tewari, R. C. Mishra, R. P. Tripathi, A .K. Srivastava, R. Ahmad, R. Srivastava
and B. S. Srivastava. International symposium on Drug Discovery and Process Research, Shivaji
University Kolhapur, January 23-25, 2003.
9. A versatile synthesis of dihydropyrimidinone C-Nucleosides. R. C. Mishra, D. Katiyar, N. Tewari,
R. P. Tripathi, International symposium on Drug Discovery and Process Research, Shivaji
University Kolhapur, January 23-25, 2003.
10. -glucosidase inhibitory potential of glycosyl ureas. N. Tewari, R. C. Mishra, R. Ahmad, A. K.
Srivastava, and R. P. Tripathi, International conference on Role of Free Radical and antioxidants in
Health and disease, King George Medical University Lucknow, February 10-12, 2003.
11. Glutathione modulatory potential of 4-alkyl-7-O-acetamidyl coumarins in malarial and filarial
parasites, D. Katiyar, K. Arora, R. Ahmad, A. K. Srivastava, and R. P. Tripathi, International
conference on Role of Free Radical and antioxidants in Health and disease, King George Medical
University Lucknow, February 10-12, 2003.
12. Synthesis and antitubercular activity of Novel purines Derivatives of 2,3-O,O-Dialkyl-6-deoxy-L-
ascorbic acid and 4,5 didehydro-5,6-dideoxy-L-ascorbic acid. N. Dwivedi, R. P. Tripathi. XXI
Carbohydrate Conference, Deptt of Chem Delhi University, 26-29 Nov. 2006.
13. Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in
asymmetric aldol reactions. Jyoti Pandey, Namrata Dwivedi, Nimisha Singh, A. K. Srivastava, A.
Tamarkarb and R. P. Tripathi XXI Carbohydrate Conference, Deptt of Chem Delhi university, 26-29
Nov. 2006
14. Synthesis and Antitubercular Activity of Nucleoside analogs based on purines and L-Ascorbic acid.
N. Singh, N. Dwivedi, M. Misra and R. P. Tripathi. Current trends in drug discovery 17-21 Feb 2007,
C.D.R.I Lucknow.
15. L-Ascorbic acid in organic synthesis:An Ecofriendly and facile synthesis of 4-vinyl-1, 4-
Dihydroryridine Surendra. S. Bisht Current trends in drug discovery 17-21 Feb 2007, C.D.R.I Lucknow.
16. An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid
Biswajit K Singh, 11 th ISCB conference (ISCBC 2007) International Conference on Advances in Drug
Discovery research Feb 24-26 2007. Dr. Babasaheb Ambedkar Marathwada University.
17. Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines Nisha
Saxena, R P, Triapthi 11 th ISCB conference (ISCBC 2007) International Conference on Advances in
Drug Discovery research Feb 24-26 2007. Dr. Babasaheb Ambedkar Marathwada University.
18. The gateway to solution phase synthesis of a library of an artificial glycopeptides: in silico
screening and antimicrobial evaluation Jyoti Pandey, A. Sharma, R. Ramachandran, V. Chaturvedi,
S. Sinha, P. K. Shukla and Rama P. Tripathi* International Conference on Biomedical and Bioorganic
Chemistry Mar 04, 2009 at Delhi University and Jan 22-24, 2009 at Bhavnagar University, Bhavnagar
(Gujarat) India.
19. Synthesis of polyfunctional alkenoyl and alkanoyl C-glycosides and their α-glucosidase
inhibitory activity.” Surendra Singh Bisht, Anindra Sharma, Arvind K. Srivastva and Rama P.
Tripathi. Presented in CARBO-XXIII conference Jan 22-24, 2009 at Bhavnagar University,
Bhavnagar (Gujarat) India.
20. Synthesis of glycopeptides based on glycosylaminoacid scaffolds Mridul Misra, Anindra
Sharma, Rama P. Tripathi, CARBO XXIV, Carbohydrate Conference, Lachoo Memorial
College of Science and technology, Jodhpur, Rajasthan, 7-9 December, 2009.
21. An attempt towards the synthesis of unnatural deoxynucleosides S. K. Pandey, B. K. Singh
and R. P. Tripathi CARBO XXIV, Carbohydrate Conference, Lachoo Memorial College of
Science and technology, Jodhpur, Rajasthan, 7-9 December, 2009.
22. Search of antimycobacterial activities in hybrid molecules with benzopyran skeletons Rama
P. Tripathi, Surendra Singh Bisht, Vivek P. Pandey, Sarvesh K. Pandey, Subhra Singh, Vinita
Chaturvedi and Sudhir Kumar Sinha 4th international symposium on Current Trends in Drug
Discovery Research (CTDDR-2010), 17th-21st February 2010.Central Drug Research Institute,
Lucknow, U.P.; India
23. Synthesis of hybrid molecules with charbohydrate aromatic and heterocyle skeletons as
potent antidiabetics Seerat Fatima, Surendra Singh Bisht, Arvind K. Srivastva and Rama P.
Tripathi 4th international symposium on Current Trends in Drug Discovery Research (CTDDR-
2010), 17th-21st February 2010, Central Drug Research Institute, Lucknow, U. P.; India.
24.Synthesis and anti breast cancer activity of biphenyl based chalcones Anindra Sharma, Munna
Prasad Gupt, Bandana Chakravarti, Rituraj Konwar, Rama P. Tripathi 4th international symposium on
Current Trends in Drug Discovery Research (CTDDR-2010), 17th-21st February 2010. Central Drug Research
Institute, Lucknow, U.P.; India
25.Synthesis ,molecular modelling and their antitubercular evaluations of benzylidene
tetrahydroquinazolines: Nimisha Singh, Richa Dwiwedi, Vinita Chaturvedi, S. Sinha,
M.I.Siddiqui and R.P.Tripathi 4th international symposium on Current Trends in Drug Discovery
Research (CTDDR-2010), 17th-21st February 2010. Central Drug Research Institute, Lucknow,
U.P.; India
26.Diastereoselective efficient synthesis of hexahydro-4-phenyl-1H-pyrano[2,3-d]pyrimidin-
2(8H)-ones (thiones) via L-Proline/TFA catalyzed Biginelli-type reaction Jyoti Pandey, N.
Anand and Rama P. Tripathi 4th international symposium on Current Trends in Drug Discovery
Research (CTDDR-2010), 17th-21st February 2010. Central Drug Research Institute, Lucknow,
U.P.; India
27. Synthesis of 1H-(1-cyclopropyl phenyl methyl) and 1-(phenyl-but-3-enyl)-azoles and their
antimicrobial Evaluations Namrata Anand, Rahul Sharma, Shubra Singh, Nipendra Mishra,
Vinita Chaturvedi, Sudhir Kumar Sinha, P.K. Shukla and R.P. Tripathi
4th international symposium on Current Trends in Drug Discovery Research (CTDDR-2010),
17th-21st February 2010. Central Drug Research Institute, Lucknow, U.P.; India
Invited Lectures:
1. Polysaccharides structure & function- its relevance to medicinal chemists-In TAB Meeting CSIR
Science centre New Delhi 9th July 1991.
2. Carbohydrtes in Drug Design- In modern Trends in chemical research: From laboratory to
Industry, March 5-7 1992, APS University Reewa, M.P.
3. Strategies in the design of antiviral agents: National Seminar organized by Purvanchal academy of
Sciences March 1993, at Neoria Jaunpur.
4. Chemotherapy of filariasis-National Seminar organized by Purvanchal Academy of Sciences
March 1993, at Purvanchal University Jaunpur 1994.
5. Development of drugs against Tuberculosis- Annual Convention Of Chemical Society of DBS
college, Kanpur University, Kanpur December 2002
6. Carbohydrates in Drug Design: National Conference on Chemistry at Interfaces-Trends and
Perspectives, December 19-20, 2003, Sant Longowal Institute of Technology, Longowal, Punjab.
7. Application of carbohydrates in development of ne chemotherapeutics APS University March
2004 New trends in Chemistry
8. Carbohydrates in Drug design: An attempt to develop new generation of Antimycobacterial
Agents XIX Carbohydrate Conference, Forest Research Institute Dehradun. Uttaranchal 1-3rd
December 2004.
9. Search of New Antimycobacterial Agents. Bundelkhand University Jhansi, Jan 2005.
10. Carbohydrates in Drug Desin against Tuberculosis. XIX Carbohydrate Conference, Chemistry
Department Lucknow University, Lucknow 23-26 Nov 2005 December 2005.
11. Role of sugars in the development of new generation of Antitubercular agents. Chemistry Deptt.
BHU Varanasi 24 March 2006.
10. Tuberculosis: New Drug Development University of Rennes1 FRANCE 13th June 2006.
11. Potential of Simple Sugars in Chemistry and Medicinal Chemistry. BHU, 30th Sept 2006.
12. Explorations in Medicinal Chemistry with Simple Sugars. Delhi University, 27th Nov 2006.
13. GLYCOCONJUGATES: NOVEL INHIBITORS OF M.TUBERCULOSIS NAD+ -DEPENDENT
DNA LIGASE (Rv3014c) BHU Varanasi, 24TH March 2007
14. Application of Monosaccharides as Chemotherapeutics NIPER Chandigarh India December 2007
15. Our effort to develop new antitubercular agents 1st International Euro-India Conference on
Holistic Medicine 21. 8. 2008 Kottayam, Kerala.
16. Antioxidant Defense System of Parasites: A Tool for Drug Discovery 27th Feb MMV BHU
Varanasi 2008.
17. Medicinal Chemistry with sugars Bhavnagar University, Bhavnagar (Gujarat) 2009.
18. Application of carbohydrate based chiral ligands for the synthesis of biologically active
compounds of potential application in Defence 04.08.2009. DRDE Gwalior
19. Development of new generation of Antitubercular agents Pretoria South Africa 3.8.2009.
20. Application of sugars in Medicinal Chemistry Allahabad University, Allahabad 09.02.2009.
21. Development of new drugs with sugars Institute of Medical Sciences BHU, Varanasi, 2009
22. Monosachharides of medicinal Importance Delhi University, Delhi 04.03.2009.
23. Developing drugs with sugars LMC Pharmacy and engineering Jodhpur Feb 2010
24. Drug DISCOVERY & Development: Role of Medicinal and PROCESS CHEMISTY 29TH May
2010 Zydus Cadila Vadodara, Gujrat
25. Application of Carbohydrate Scaffolds in Synthesis of New Generation of Anti-diabetic
Agents Carbo XXV Shimla University Himachal Pradesh 11.11. 2010.
Chapter in Books:
Triazolyl Carbohydrate in Medicinal Chemistry, R P Tripathi,* P Dwivedi, A
Sharma, D Kushwaha, V K Tiwari, Book Title ?Click Chemistry in
Glycoscience: New Developments and Strategies?, John Wiley & Sons
Publication, Editor: Zbigniew J. Witczak (Invited article, accepted).
