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Agenda
• Structures – Origami – Branched Annealing– Nanotubes– Alternative Materials
• Patterning and Application– Combing– Origami as Scaffold– Micropatterning Nanotubes
Origami Structures
Rothemund “Folding DNA to create nano-scale shapes and patterns” Nature Articles (2006)
Origami Structures
Rothemund “Folding DNA to create nano-scale shapes and patterns” Nature Articles (2006)
Nano-Tube Structures
Chen et. al. “Approaching The Limit: Can One DNA Oligonucleotide Assemble into Large Nanostructures?” (2006)
Other Forms of Nucleic Acid
Lin et. al. “Mirror Image DNA Nanostructures forChiral Supramolecular Assemblies” Nano Letters (2009)
Combing Linear DNA for Nanowires
Deng and Mao “DNA-Templated Fabrication of 1DParallel and 2D Crossed Metallic
Nanowire Arrays” Nano Letters (2003)
DNA Origami as a Scaffold
•RNA/DNA hybridization assays
Ke et. al. “Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays”
Science (2008)
DNA Origami as a Scaffold
Ke et. al. “Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays”
Science (2008)
DNA Origami as a Scaffold
Rinker et. al. “Self-assembled DNA nanostructuresfor distance-dependent multivalentligand–protein binding” Nature Letters (2008)
Micropatterning Nanotubes
Lin et. al. “Functional DNA Nanotube Arrays: Bottom-Up Meets Top-Down” Ange Chem (2007)
2D Patterning Branched Annealing Structures
• Rigidity of “monomers” affects 2/3D structure.
• Varying the length of red region produces different flexibilities.