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2013-05-05
1
Ge kroppen föda och själen näring!Del 2
Hur äter Du människa – Vad tycker Dina celler och
skyddsbakterier?
Stig Bengmark MD PhD, UCL, London University, UK
www.bengmark.com
Arrangemang av Pingstkyrkan & Radio Falköping i samarbete
med Hälsofrämjandet
DNA – Not Your Destiny!Anand P et al Pharm Res 2008;25:2097-2116
Stressors like a calorie-rich diet turn genes on and off, activate epigenetic markers,
modify histones, & seem to affect what gets passed down to the offspring
DESCRETE PERSISTANT INFLAMMATION
- A MOTHER OF DISEASE
Bengmark S. J Clin Nutr 2004;23:1256-1266
Increase of ChDs 1850 – 2005 parallel to:100 % increase in consumption of saturated fats
2500 % production of milk/cow (2 l/d => 50 l/d )
10000 % increase in refined sugar intake (1 lb => 100 lb)
DESTABILIZING FACTORSExcess of refined processed foods: dys-functioning proteins (AGEs & ALEs), fats, sugars, hormones & chemicals; pharma, environmental toxins etc.
increases pro-oxidant actions, stimulates over-expression of inflammatory messengers, reduces flora, increases membrane leakages, destabilizes the immune system
Contributory are:
Lack of physical activity
Mental and physical stress
Vitamin D deficiencydecreases resistance to disease
MAJOR HEALTH THREATS
& life expectancy
Stress ? years
Low physical activity ? years
Obesity ? years
Alcohol abuse 4 - 5 years
Tobacco abuse 8 - 12 years
Food abuse 20 - 25 years
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FOOD INTAKE & INFLAMMATION • 1. Low intake of fresh plant foods;
GREENS, vegetables, fruits, spices. Higher intake of proteotoxins in certain foods: casein, gluten, zein (corn) etc.
• 3. Higher intake of heat- and storage-inducedproteotoxins: glycated (AGEs), lipoxidatedmolecules (ALEs),processed carbohydratesinduces: - Dysbiosis: reduced numbers & diversity- Various body membranes leak like a sieve; leaky gut, leaky airways, leaky skin, leaky vagina, leaky eye cavity , leaky nose, leaky placenta, leaky blood-brain barrier etc.
Dennis Burkitt 1911 - 1993Suggested that many
Western diseases, rare in
Africa are primarily the
result of diet and lifestyle.
Reported an association
between low fibre in diet
higher risk of colorectal
cancer and other chronic
diseases such as
CHV and diabetes
GI PERISTALSIS – UK vs UGANDA
Appr GI transit time:
UK: 100 hrs vs Uganda: 20 hours
Appr stool weight:
UK 60 g/day vs Uganda 600 g/day Burkitt DP et al Lancet 1972;300 (7792):1408-11
British geriatric patients:
GI transit time: >14 days
in > half of the patientsBrocklehurst JC, Khan MY. Gerontol Clin 1969;11:293-300
FERMENT YOUR VEGETABLES
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1800, 1812, 1821,
1836 and 1856 were
years of total crop
failure and extreme
suffering & 1801,
1822, 1828, 1844
and 1863 were
years with food in
abundance.
Bygren LO et al Acta
Biotheor 2001
;49:53-59
MOTHER´S EATING– EFFECTS ON OFFSPRINGCanini RB et al Nutr Res Rev 2011 E-pub
NONBREAST-FEEDING & UNHEALTH
Non-breastfeeders: - have an increased chance of becoming over-weightChapman DJ J Hum Lact 2009;25:242–243
- suffer an increased risk of breast-cancer later in lifeStuebe AM et al Arch Intern Med 2009;169:1364–1371
- are less stress-resistent Mezzacappa ES et al. J Psycho Res 2005;58:351–365
- are more prone to get depression after deliveryGallup Jr GG et al Med Hypotheses 2010;74:174–176
- may contribute to autism in the next childGallup GC et al Medical Hypotheses 77 2011;77:345–346
Daily Mail 2011 Dec 22 - Commentary to IGF-1 & Breastfeeding
Madsen AL et al Growth Horm IGF Res 2011;21:199-204
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Maccaferri S et al Dig Dis 2011;29:525–530
LEAKY BARRIERS
• Gastrointestinal tract
• Airways
• Skin
• Oral cavity
• Vagina
• Nose
• Eye cavity
• Placenta
• Blood brain barriers
METABOLIC SYNDROME – DYSBIOSISTremellen K, Pearce K Med Hypotheses 2012;79:104-112
DIFFERENT MICROBIOTA IN OBESE vs LEANAngelakis E et al Future Microbiol. 2012;7: 91–109
GUT MICROBIOTA & METABOLISMVrieze A et al Diabetologia 2010;53:606-613
↓ FaMy acid oxidaNon
↑ LPS (endotoxin) – inflammation
↓ Buturate secreNon
↑ FaMy acid oxidaNon
↓ LPS – inflammation
↑ Buturate secreNon
MICROBIONTA, ENDOTOXIN & OBESITY
Muccioli GG et al Mol Syst Biol 2010;6:392
Obesity is characterised by altered gut
microbiota & low-grade inflammation
ENDOTOXIN (LPS) acts as a master switch
to control adipose tissue metabolism
Gut microbiota regulates
plasma lipopolysaccharide (LPS) levels,
gut permeability & adipogenesis
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OBESITY – A METABOLIC DISORDERCani PD, Delzenne NM Curr Pharm Des. 2009;15:1546-1558
OBESITY – A METABOLIC DISORDERCani PD, Delzenne NM Curr Pharm Des. 2009;15:1546-1558
OBESITY – A METABOLIC DISORDERCani PD, Delzenne NM Curr Pharm Des. 2009;15:1546-1558
INFLAMMATION IN OBESE PREGNANT WOMEN
Basu S et al Obesity 2011;19:476-482
PALEOLITHIC DIET“Much support that our genes, adapted during million of
years to the lifestyle of our prehistoric ancestors badly
tolerate the dramatic changes, especially in food habits,
which have occurred”.
Eaton BS, Konner M. Paleotlithic nutrition: a consideration of its nature and current implications. N Engl J Med 1985;312:283-289
Contained more of: (X = times more)
Minerals 2 X
Fibers/greens 4 to 10 X
Antioxidants 10 X
Omega-3 FA 50 X
Lactic acid bacteria >1010 X
Contained less of:(X = times less)
Protein 2 X
Saturated FA 4 X
Sodium 10 X
Proc carbohydrates >1000 X
LIFESTYLE & CHOLESTEROL/S
Mg/dL mM/L
Westerners <200 <5.18
Rural Chinese 127+15 3.3+0.4
Hunters-gatherers 123+7 3.2+2.2
Other Primates 90-135 2.3-3.5
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Homo erectus2 milj – 100 000 years bC
”diet consisted of
leaves, wild grasses,
nuts, berries, flowers,
less often tubers, roots,
honey, occasional red
meat, shellfish and
bird's eggs.”
OMEGA-3/OMEGA-6 RATIO Simopoulos AP Mol Neurobiol 2011;44:203-215
FOREFATHER´S CHOICES
1. To store foods in the soil
2. To use heat for production and
preparation of foods
3. To cultivate grains for food
4. To domesticate animals
RECENT GENERATIONS ADDED
MANIPULATIONS:• PLANT BREEDING
• ANIMAL BREEDING
• MODERN AGRICULTURE• FOOD PROCESSING: separation, condensation, drying , freezing, irradiation, burning, roasting, curing, microvawing, emulsifying, toasting , supplementing salt etc
• BAKING
• COOKING
• FRYING
• GRILLING
• etc.
HEATING EFFECTS:
� app 28 C antioxidants start to disappear> app 41 C food enzymesinactivated
� > 80 C addition ofglycated and lipoxidatedmolecules called AGEs & ALEs
� > app 130 C addition ofheterocyclic amines
VITAMIN D DEFICIENCY COMMON IN PATIENTS
Burkina Faso:
115nmol/L
(> 70 nmol/L)
Luxwolda MF
et al. Brit J Nutr
2012; E-pub
• 95% of Afro-Americans undergoing renal transplantation Tripathy SS et al Transplantation 2008;85: 767–770
• 85 % of patients undergoing hip or kneereplacement
• Breijawi N et al Eur Surg Res 2009;42:1–10
• 77 % of chronic pancreatitis patients Dujsikova H et al Pancreatology 2008;8:583–586
• 67 % of renal transplantation patients Ducloux D et al Transplantation 2008;85: 1755–1759
• 57 % obesity surgery patients (79 % in black and Hispanic) Gemmel K et al Surg Obes Rel Dis 2009,5, 54–59
Vitamin D deficiencies (< 30 mol/L)
In Westerners undergoing surgery:
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VITAMIN D DEFICIENCY & DISEASE• Aging
• Allergy
• Alzheimer’s disease
• Asthma
• Athletic performance
• Autism
• Cancer
• Cavities
• Colds
• Crohn´s disease
• Cystic fibrosis
• Depression
• Diabetes 1 and 2
• Eczema
• Heart disease
• Hearing loss
• Hypertension
• Infertility
• Influenza
• Insomnia
• Liver diseases
• Macular
degeneration
• Migraines
• Multiple Sclerosis
• Muscle pain
• Obesity
• Periodontal disease
• Pre-eclampsia
• Psoriasis
• Rheumatoid
diseases
Schizophrenia
• Seizures
• Septicemia
• Tuberculosis
MICROBIOTA, AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696
MICROBIOTA, AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696
MICROBIOTA, AFRICAN & EUROPEANDe Filippo C et al Proc Natl Acad Sci USA 2010; 107:14691–14696
Maccaferri S et al Dig Dis 2011;29:525–530
LEAKY BARRIERS
• Gastrointestinal tract
• Airways
• Skin
• Oral cavity
• Vagina
• Nose
• Eye cavity
• Placenta
• Blood brain barriersBoutenko V.
Green for Life. North Atlantic Books
Calif, USA, 2010
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80/10/10 DIET80 % raw greens
10 % vegetable fats
10 % vegetable proteins
DIET & LONGEVITYRobbins J: Health at 100. USA 2007
HYPOTHESIS: NUTRITION-INDUCED METABOLIC DISORDERS
Cani PD et al Diabetes 2008;57:1470-1481
LPS concentration 10 to 50 X higher
than those obtained during septic
shockMitaka C. Clin Chim Acta 2005; 351(1-2):17-29
Bifidobacterim
spp.
ENDOTOXIN & PROSPECT OF LIFEPussinen PJ et al. Diabetes Care 2011; 34:392–397
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ENDOTOXIN-ASSOCIATED DISEASES• Alzheimer Jaeger LB et al. Brain
Behav Immun. 2009 May ; 23(4): 507–
517
• Cognitive impairment Lee JW
et al. J Neuroinflammation 2008; 5: 37
• Arterio-/Coronary Diseases Heo SK et al Immunol Lett 2008;120:57-
64
• Diabetes type 1 Nymark M et al
Diabetes Care 2009 32(9): 1689–1693
• Diabetes type 2 Andreasen AS
Intensive Care Med. 2010;36:1548-1555
• Cancer Hsu RY et al Cancer Res.
2011;71(5):1989-1898
• ADHD, allergy, ALS, autism, autoimmune diseases, bipolardisease, cataracts, chronicfatigue syndrome, COPD, minimal encephalopathy, fibromyalgia, glaucoma, gulf war syndrome, HIV, iritis, liver cirrhosis, maculardegeneration, multiplesclerosis, nephropathies, obesity, osteoporosis, paradontosis, Parkinson, polycystic ovary syndrome, rheumatoid disease, schizophrenia, stress, stroke, uveitis
ENERGY INTAKE & ENDOTOXIN/plasma Amar J et al Am J Clin Nutr. 2008;87:1219-1223
A FAT-RICH MEAL & INFLAMMATION Erridge E et al Am J Clin Nutr 2007;86:1286-1292
• Increases circulating leukocytes (neutrophils, lymphocytes, and platelets)
• Activates of the transcription factor nuclear transcription factor B (NF-B) in peripheral blood mononuclear cells
• Increases expression of tumor necrosis factor-(TNF-) in monocytes
• Alters some surface adhesion molecules in neutrophils and monocytes
• Activates Toll-like receptor 4 (TLR4) complex &
• Activates platelets and coagulation
ANIMAL FAT INTAKE – PANCREATIC CANCEROtsuko M, Tashiro M Intern Med 2007;46:109-113
FOOD & RISK OF PANCREATIC CANCERChan JM et al Cancer Causes Control 2007;18:1153-1167
• total dairy 2.6
• butter 2.4
• beef/lamb 2.2
• hamburgers 1.7
• egg 1.7
• chicken 0.7
• Highfat/processed-
meat products:
sausage, salami,
bacon especially
associated with risk:
• animal fat 1,9
• saturated fat 1.9
• total fat 1.6
• cholesterol 1.5
• monounsaturated fat 1.3
PROCESSED FOODS INDUCE DYSBIOSIS - Animal products (espec. dairy), rich in IGF-1
- Refined carbohydrates promotes IGF-1 synthesis in
the liver
• Increase expression of inflammatory messengers
• Induce dysbiosis
• Increase expression of inflammatory messengers
• Increase membrane leakages &
• Destabilize the immune system
Contributory are: Mental & physical stress, lack of physical
activity,, vitamin D deficiency, lack of anti-inflammatory
minerals; Mg, Zn, Se, lack of omega-3 FFAs etc.
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HIGH FAT MEAL – ENDOTOXIN/sHarte AL et al Diabetes Care 2012;35:375-382
Non-obese controls (NOC) (n = 9), obese subjects (n = 15), impaired glucose tolerance (IGT) (n = 12), type 2 diabetes (n = 18).
HIGH FAT DIET & MICROBIAL TRANSLOCATIONAmar J et al EMBO Mol Med 2011;13:559-572
Live intestinal bacteria found present in large numbers in
adipose tissue (MAT), mesenteric lymph nodes (MLN) and
blood AFTER ONLY ONE WEEK ON HIGH FAT DIET (HFD)
INTAKE OF FOOD & INFLAMMATIONErridge C Brit J Nutr 2011;105:15-23
MEAT STORAGE – INFLAMMATION INDUCTIONErridge C J Food Sci 2011,76,72-79
VEGETABLE STORAGE – INFLAMMATION INDUCTIONErridge C Food and Chemical Toxicology 2011;49:1464–1467
HIGH FAT INTAKE, ENDOTOXIN/pl & LEAKY GUTCani PD et al Diabetes 2008;57:1470-1481
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ALMOST HALF OF
WESTERN BABIES BORN
BY CESAREAN SECTION
INFECTED DURING
THIRD SEMESTER OF
PREGNANCY
FETAL LIFE & IMPAIRED PROGRAMMING
Barker David JP, Southhampton:Curr Opin Nephrol Hypertens 1997; 6:106-110
“We have become accustomed to the idea that the major
disorders of adult life, including coronary heart disease,
stroke and diabetes, arise through interaction between
influences in our adult lifestyle and genetically determined
susceptibility. Recent research, however, suggest that
growth in utero may also play an important role.”
“Even brief periods of …………may permanently change or
`programme` the body…………………………………
and lead to persistent changes in blood pressure,
cholesterol metabolism, insulin response to glucose, and in
a range of other metabolic, endocrine and immune
parameters.” …… and chronic diseases later in life
LEAKY PLACENTAA shocking 9/20 (43 %) of umbilical cord blood, cultivated from healthy neonates born by cesarean section, demonstrated positive growth: Enterococcus faecium, Propionibacterium acnes, Staphylococcus epidermidis & Streptococcus sanguinisJiménez E et al. Curr Microbiol 2005;51:270–274.
ATHEROSCLEROSIS & BACTERIAL DEBRISNicolaou G et al J Atheroscler Thromb 2012;19:137-1498
Bacteria & bacterial debris
in human atheroma, in the
past considered harmless,
seems to
contribute to disease
progression via
TLR-dependent lipid body
formation in macrophages
CHRONIC DEPRESSION & LEAKY GUTMaes M J Affect Dis 2012 E-pub
CHRONIC DEPRESSION & LEAKY GUTMaes M J Affect Dis 2012 E-pub
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ENDOTOXIN & METABOLIC SYNDROMEPussinen PJ et al. Diabetes Care 2011; 34:392–397
ALZHEIMER, NEUROINFLAMMATION &
ENDOTOXIN (LPS)Piazza A, Lynch MA Biochem Soc Trans. 2009;37:303-307
FATTY ACIDS & INFLAMMATION(in vitro) Weatherill AR et al J Immunol 2005;174:5390-5397
• The saturated fatty acid, lauric acid, upregulates in dendritic cells and produce inflammation:
• Expression of costimulatory molecules (CD40, CD80, & CD86)
• MHC class II
• Cytokines (IL-12p70 and IL-6) &
• Increased T cell activation
• In contrast, the n-3 polyunsaturated fatty acid, docosahexaenoic acid inhibits inflammation:
• LPS-induced up-regulation of the co-stimulatory molecules
• MHC class II, and cytokine production
• LPS-induced T cell activation induced
PALMITATE-INDUCED INFLAMMATIONOberbach A et al PLoS One 2010; 28;5:e10882
Saturated free fatty acids (FFAs) especially palmitic acid (16:0),and
stearic acid (18:0) stimulate macrophage activation of NFκ-B &
expression of pro-inflammatory cytokines.
PALMITATE & ASTROCYTE INFLAMMATION(in vitro) Gupta S et al J Neurochem 2012;120 :1060-1071
HIGH FAT DIET & ALLERGYWoods LG et al J Allergy Clin Immunol 2011;127:1133-1140
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VEGAN DIET & HEALTHKatcher HI et al Ann Nutr Metab 2010;56:245–252
Employees ( insurance company) with overweight and/or diabetes received either a low-fat vegan diet or regular food for 22 weeks. The vegan group reported improvements in: ● general health (p = 0.002)
● physical functioning (p = 0.001)
●mental health (p = 0.03)
● general vitality (p = 0.004)
● overall diet satisfaction (p = 0.001)
● reduced food costs (p = 0.003), but
● increased difficulty finding foods when eating out
Bill Clinton Turns 65
– and Vegan!Friday Aug 18.2011
Once known for his love of barbecue and
impromptu stops at McDonald's, former
President Bill Clinton has radically changed
his diet, dropped weight and improved his health.
The former junk food lover now calls himself a vegan,
shunning meat, eggs, dairy and almost all oil."I like the vegetables, the fruits, the beans, the stuff I eat now," Clinton tells CNN.
After experiencing periodic heart problems leading up to the 2004 surgery,
Clinton has now lost 20 lbs. and says:
"I feel good, and I also have … more energy."
• pH 9.0 –watermelon,
asparagus, garlic, carrot
• pH app 8,5 - dates, figs,
apricots, mango, parsley,
lemon, lime, grape fruit,
algae, sea grass
• Green leaves – espec
organic: spinach, arugula,
broccoli, germs, nettles
• Fruits – espec organic:
avocado, pear, apple,
banana, berries, grapes,
peach
• pH app 8.0 - peas,
pumpkin, parsnip
• pH app 7.5 –green beans and
peas, pepper, red beat, broccoli,
various cabbages
• Fish – preferable wild
• Nuts, almonds & seeds – espec
organic: - pumpkin seeds, sesame
seeds, flaxseeds, sun flower
seeds etc
• Various beans and sprouts; chick
peas, black peas etc, buckwheat
• Spices- ginger, turmeric,
cinnamon, cardamom etc
• Himalaya mineral salt, carob,
• coconut
• Vegetable fats – flax oil, coconut
oil , canola oil, olive oil, avocado
oil etc.
DYSBIOSIS-INDUCED METABOLIC DISORDERS Cani PD et al Diabetes 2008;57:1470-1481
LPS concentration 10 to 50 X higher
than those obtained during septic
shockMitaka C. Clin Chim Acta 2005; 351(1-2):17-29
Bifidobacterim
spp.
ENDOTOXIN-THE VILLAIN? ASSOCIATED DISEASES:
Alzheimer Jaeger LB et al. Brain
Behav Immun. 2009; 23: 507–17
Cognitive impairment Lee JW et
al. J Neuroinflammation 2008; 5: 37
Arterio-/Coronary Diseases Heo SK et al Immunol Lett
2008;120:57-64
Diabetes type 1 Nymark M et al
Diabetes Care 2009 32(9): 1689–
1693
Diabetes type 2 Andreasen AS
Intensive Care Med. 2010;36:1548-
1555
Cancer Hsu RY et al Cancer Res.
2011;71(5):1989-1998
Chronic Liver diesases Nolan JP
Hepatology 2010;52:1829-1835.
•ADHD, allergy, ALS, autism,
autoimmune diseases, bipolar
disease, cataracts, chronic
fatigue syndrome, COPD,
fibromyalgia, glaucoma, gulf war
syndrome, HIV, iritis,
macular degeneration, minimal
encephalopathy, multiple
sclerosis, nephropathies,
obesity, osteoporosis,
paradontosis, Parkinson,
polycystic ovary syndrome,
rheumatoid disease, stress,
schizophrenia, stroke, uveitis
FLORA IN WESTERNERS• Lb plantarum, a dominating LAB,
in only 25 % of omnivorous Americans & in 65 % of vegetarian AmericansFinegold SM et al. Human intestinal microflora in health and disease Academic Press, London, UK, 1983. pp 3-31
• Common colonic LAB species present only in
• about 50 % or less of healthy Scandinavians:Lb plantarum 52 %, Lb rhamnosus 26 %,Lb paracasei ssp paracasei 17 %Ahrné S et al. J Appl Microbiol 1998;85:88-94
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MICROBIOTA & OBESITYMillion M et al. Int J Obesity 2012;36:817-825
Obese (n=68) Controls (n=44) P-value
L. plantarum 0 (0%) 8 (18.2%) 0.0004
L. paracasei 10 (14.7%) 17 (38.6%) 0.004
L. reuteri 6 (8.8%) 1 (2.3%) 0.16
L. rhamnosus 3 (4.4%) 4 (9.1%) 0.27
L. ruminis 3 (4.4%) 4 (9.1%) 0.27
L. salivarius 5 (7.4%) 2 (4.5%) 0.43
ENDOTOXIN
& OBESITYFei N, Zhao L. ISME J.
2012. Epub 13 dec
HUMAN GUT MICROBIONTA & OBESITYLey RE et al. Nature 2006; 444:1022-1023
12 obese individuals
Fat- & carbohydrate restricted diet for 52 weeks
The relative numbers of Bacteroidetes
increased & the numbers of Firmicutes
decreased significantly
Increased numbers of Bacteroidetes correlated
with percentage loss of body weight
ENDOTOXIN & OBESITYFei N, Zhao L. ISME J. 2012 Epub 13 dec 2012.
A person weighing 174.8 kg lost 51.4 kg after
23 weeks on traditional Chinese medicinal
foods, whole grains, & prebiotic fibres
recovered totally from hyperglycemia and
hypertension.
The endotoxin-producing Enterobacter cloacae
B29 - found to constitute 35% of the gut
bacteria - decreased to non-detectable.
The Enterobacter cloacae inoculated in germfree
mice induces obesity and insulin resistance.
ELEMENTAL COMPOSITION OF THE BODYElement Percent by mass Atomic percent (calc.)
Oxygen 65% 25.6%
Carbon 18% 9.5%
Hydrogen 10% 63%
Nitrogen 3% 1.3%
Calcium 1.5% 0.24%
Phosphorus 1.2% 0.24%
Potassium 0.2% 0.03%
Sulfur 0.2% 0.04%
Chlorine 0.2% 0.04%
Sodium 0.1% 0.03%
Magnesium 0.05% 0.01%
Iron 3 g in men, 2.3 g in women
Cobolt, Copper,
Zinc, Iodine< 0.05% each
Selenium, Flour < 0.01% each
MG-DEFICIENCY & METABOLIC DISORDERSMagnesium (Mg), an essential mineral, required
for cellular energy-dependent reactions involving
ATP and the regulation of calcium channel
function.
Subclinical hypomagnesemia
- increases the severity of the systemic
inflammatory response
- worsens the systemic response to endotoxins,
- increases endotoxemia, insulin resistance,
- promotes organ injuries, commonly seen in
critically ill and in various chronic diseases
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MAGNESIUM/s & MORTALITY Reffelmann T et al. Atherosclerosis 2011;219:280-284
Mortality in subjects with Mg++ ≤ 0.73 mmol/l was in comparison to
higher Mg++ concentrations significantly higher for all-cause deaths:
10.95 death vs 1.45 deaths (7x) & for cardiovascular deaths: 3.44
deaths vs. 1.53 deaths (2.4x) per 1000 person years.
MAGNESIUM – A KEY MOLECULE IN CELL REPLICATION
Mg involved in > 300 biochemical processes
Mg deficiency associated with:
• Anxiety and panic Asthma
• Bladder problems, cystitis
• Body aches
• Chronic bowel problems
• Diabetes type 2 &
metabolic syndrome
• Dysmenorrhea
• Eclampsia
• Fatigue
• Headaches, migraine
• Heart disease
• Hypertension
• Hypoglycemia
• Insomnia
• infertility
• Insulin resistanse
• Kidney Disease
• Leg cramps
MAGNESIUM DEFICIENCY – ASSOCIATED
DISEASES cont
• Liver Disease
• Low energi
• Musculoskeletal
conditions
• Muscle twitches
• Nerve problems
• Obesity
• Premenstrual syndrome
• Premature contractions
• Restless legs
• Stroke
• Sudden Infant
Death Syndrome
(SIDS)
• Raynaud's
Syndrome
• Tooth decay
MAGNESIUM & SEPSIS PROTECTION
• Magnesium replacement
provides significant protection
against endotoxin Salem M et al Crit Care Med 1995;23:108-118
• Administration of Mg to animals
with sepsis improves organ
function and survival time Harkema JM et al Crit Care Med 1992;20:263-275
HYPOMAGNESEMIA IN CRITICALLY ILLLimaye CS et al J Assoc Physicians India 2011;59:19-22
52% of patients show Mg-deficiency on
admission to MICU & suffer increased:
• Mortality rate (57.7% vs 31.7%)
• Need for ventilatory support (73% vs 53%)
• Duration of mechanical ventilation
(4.27 vs 2.15 days),
• Rate of sepsis (38% vs 19%)
• Hypocalcemia (69% vs 50%)
• Hypoalbuminemia (80.76% vs 70.8%)
MAGNESIUM – DAILY REQUIREMENT
Children: 1-3 years old: 80 milligrams
4-8 years old: 130 milligrams
9-13 years old: 240 milligrams
14-18 years old (boys): 410 milligrams
14-18 years old (girls): 360 milligrams
Adult: Females: 310 milligrams
Pregnancy: 360-400 milligrams
Breastfeeding women: 320-360 milligrams
Males: 400 milligram
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MAGNESIUM IN FOODS mg/100 gr
• Pumpkin &Squash seeds 540
• Cacao 20-22 % 520
• Wheat bran 355
• Sesame seeds 350
• Wheat germs 290
• Almonds 280
• Soya beans 265
• Cashew nuts 260
• Rosehip, dry 240
• OAT bran 235
• Peanuts 190
• Beans 190
• Peas 150
• Lentils 80
• Spinach 79
• Prunes 52
• Avocado 41
• Banana 35
• CHEESE 35
• Broccoli 23
• FRENCH FRIES 35
• BREAD, whole wheat 24
• HAMBURGERS 20
• KETCHUP 18
• MILK 15
• CREAM 14
• BUTTER 3
ZINC IN FOODS mg/100 g
(Daily need: 10 -15 mg) • Wheat germ 18
• Dry yeast 14
• Sesame seed 10.2
• Flaxseed, dry 7.8
• Pumpkin seed 7.5
• Squash seed 7.5
• Cacao 7.0
• Pecan nuts 5.5
• Sunflower seeds 5.1
• Liver 4-7
• BEEF 4-6
• Soy protein 4.4
• Brazil nuts 4.2
• Peas 3.8
• Lentils 3.1
• Peanuts 3.1
• BACON 3.0
• Walnuts 3.0
• CHEESE 2-3
• BREAD whole wheat 1
FRENCH FRIES 0.4
• Milk 0.4
• CREAM 0.3
• BREAD, Wheat 0
SELENO-ENZYMES DEFICIENCIESFoster HD Med Hypotheses 2007;69:1277-1280
• Selenium• depressed glutathione peroxidase
oxidative stress
• depressed CD4 T lymphocytes
• depressed trijodothyronine
• myocardial infarction
• Kaposi’s sarcoma
• depression
• Cysteine• depressed glutathione
• poor wound healing
• abnormal immune function
• psoriasis
• infections and cancers
• Glutamine• depression
• compromised gut barrier integrity
(relaxation of tight junctions)
• diarrhea
• muscle wasting
• Tryptophan• depressed niacin and serotonin
• immune incompetence
• neuroendocrine disregulation
• polyneuropathy
• dementia
• dermatitis
• diarrhea
CYSTEINE IN FOODSmg/100 gr food
• Wheat germs 750
• Gelatin 670 Lamb 600
• Sesami seeds 520
• Wheat bran 440
• Oat 390
• Almonds 360
• Walnuts 350
• Peanuts 340
• Beans, dried 315
• Soya beans, dried 310
• Chicken 290
• Turkey 280
• Parmesan cheese 270
• Peas, dried 240
• Lentils, dried 230
• HAMBURGERS 110
• CHEESE 100
• Banana 60
• Figs 60
• FRENCH FRIES 28
• KETCHUP 5
METHIONINE IN FOODSmg/100 g food
• Brazil nuts 1010
• Sesame seeds 900
• Cheese 900
• Gelatin 670
• Roast chicken 801 Swiss cheese 784
• Baked codfish 679
• Fish 600
• Chicken 570
• Beef 560
• Pumpkin seeds 550
• Roast ham 535
• Dry yeast 520
• Sunflower seeds 490
• Wheat germs 470
• Soya beans, dried 410
• Hard boiled egg 392
• HAMBURGERS 360
• Beans, dried 325
• Peanuts, dried 280
• Peas, dried 260
• Almonds 230
• Cereals app 200
• Lentils, dried 190
• Banana 75
• Tofu 74
• KETCHUP 11
VITAMIN K IN FOODS mcg/portion
• Brussels sprouts,1/2 cup 460
• Broccoli, 1/2 cup 248
• Cauliflower, 1/2 cup 150
• Swiss Chards * 1/2 cup 123
• Spinach, raw, 1 cup 120
• BEEF, 3.5 oz 104
• PORK, 3.5 oz 88
• EGGS, whole, large 25
• Strawberries, 1 cup 23
• Oats, 1oz, dry 18
• MILK, 8 oz, whole 10 * mangold
2013-05-05
17
HEALTH – TEN COMMANDMENTS
7 NOS (restrict) & 3 YES (increase) 1. Restrict intake of IGF-1-inducing foods (refined carbohydrates)
2. Restrict intake of IGF-1-rich foods (dairy products)
3. Restrict intake of highly pro-inflammatory fructose
4. Restrict intake of foods heated above 100o
5. Restrict exposure to in microbe-derived highly inflammatory
endotoxin
6. Restrict exposure to chemicals including pharmaceutical drugs
7. Eliminate/Minimize intake of foods rich in proteotoxins such as
casein, gluten and zein (corn)
8. Increase the intake of fresh and raw greens, fresh spices and
vegetables -
9. Increase intake of ancient anti-oxidant-rich, high fiber, low-calorie
containing grains, seeds, peas, beans, almonds & nuts
10. Supplement vitamin D and omega fatty acids in large doses
The Saddleback Church InitiativeCollective Loss of 260 000 lbs – 130 tonsRick Warren - The Daniel Plan Fotograf: Shaon Fox
SUBSTITUTING VITAMIN DGant WB et al Prog Biophys Mol Biol 2009, 99:104-113
to all European to 40 ng/mL would reduce the direct economic burden of disease by 11.4%, or EUR 105,000 000 000
the indirect economic burden of disease by 6.4 % or EUR 82,000 000 000
the total reduction in economic burden of disease by 17.7%, or
EUR 187,000 000 000