March – April 2019RESEARCH BULLETIN

DMD19 STUDENTS RECEIVE HONORS IN RESEARCH

Morgane Amat “A student driven,

multidisciplinary, community health-oriented nutrition education initiative at HMS and HSDM” Honors in

Global and Community Health

Mentor Dr. David Hirsch

Petra Bachour“Consistency and mechanistic implications of genomic risk prediction studies for cancer regimen-related mucosal injury”

Mentor Dr. Stephen Sonis

Fiorella Candamo “The microbiological and mechanical effects of silver diamine fluoride on caries arrest”

Mentor Dr. Rosalyn Sulyanto

Jacob Freilich“Burning mouth syndrome: A diagnostic challenge”

Mentor Dr. Alessandro Villa

Puhan He“Medicolegal analysis of OMFS malpractice claims and tooth extraction cases”Mentor Dr. Salim Afshar

Deepti Kaharde“What is the prevalence of undiagnosed nevoid basal cell carcinoma syndrome in children with an odontogenic keratocyst?” Mentor Dr. Bonnie Padwa

Jillian Muhlbauer“Long-term follow-up and management outcomes of topical therapies for oral chronic graft-versus-host disease”Mentor Dr. Nate Treister

Elaina Pullano“Is maxillomandibular advancement associated with comorbidity reduction in patients with obstructive sleep apnea?” Mentor Dr. Meredith August

Sarah Wicheta“Discrepancies in interpretation of the minor salivary gland biopsy in the diagnosis of Sjögren syndrome”Mentor Dr. Meredith August

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NEW RESEARCHERS

Shelyn A. Yamakami, DDS, MSc, PhD, is a postdoctoral research fellow working with Hiroe Ohyama DMD, MMSc, PhD, Pre- Doctoral Director of Operative Dentistry in the Department of Restorative Dentistry and Biomaterials Sciences. Yamakami holds a DDS and a MSc degree from the University

of Maringá and currently holds a PhD from the University of São Paulo. She has been investigating the design of dental materials and their molecular interaction with the dental structure. At HSDM, she will continue her work on dental restorative materials, as well as investigating dental education policies.

Renyan Liu, MD, PhD, is a postdoctoral research fellow in the Yang Lab in the Department of Developmental Biology. Originally from Wuhan, China, Liu received his MD degree from Tongji Medical College of Huazhong University of Science and Technology, and PhD degree in Pharmacology from the State University of New

York Upstate Medical University. Previously Liu worked on genetics and cell signaling related to cancer and diabetes. In the Yang Lab, Liu is currently investigating the roles of Hippo signaling in liver tumorigenesis.

Muruganandan Shanmugam, PhD, joined the Ionescu Lab as a Research Associate in the Department of Developmental Biology. He holds a Master’s and PhD degree in Pharmacology from the Indian Veterinary Research Institute, Izatnagar. His postdoctoral studies were at Dalhousie University, Canada,

where he worked on signaling pathways guiding the self-renewal and differentiation of bone stem cells . His current work in Ionescu laboratory at HSDM will focus on the identity and functional role of a novel class of stem cells residing in the growth plate cartilage. This study may lead to therapeutic strategies for growth plate cartilage regeneration.

HSDM RESEARCH DAY

Dr. Jarshen Lin with Jacquelyn Chou, DMD19

Dr. Jevae Nelson, MMSc19 with Drs. Steffany Chamut and Monina Klevens

Dr. Reshma Menon with Dr. Lucas Patrick, MMSc19

Dr. Meral Nadra, DMSc19

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Bøllehuus Hansen L, Lorenzen M, Bentin-Ley U, Nielsen J, Krog H, Hayden Berg A, Håkansson B, Munk Pedersen A, Høst T, Juul A, Blomberg Jensen M. Presence of the vitamin D inactivating enzyme CYP24A1 in human sperm and prediction of the success of intrauterine insemination: a prospective study. Journal of Steroid Biochemistry and Molecular Biology 2019; Apr 6.

Colombo A, Tanner A. The role of bacterial biofilms in dental caries and periodontal and peri-implant diseases: A historical perspective. Journal of Dental Research 2019;98(4):373-385.

Dominy S, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger L, Arastu-Kapur S, Kaba S, Lee A, Ryder M, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker G, Reynolds E, Faull R, Curtis M, Dragunow M, Potempa J. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances 2019;5(1):eaau3333.

Goodson J, Shi P, Razzaque M. Dietary phosphorus enhances inflammatory response: A study of human gingivitis. Journal of Steroid Biochemistry and Molecular Biology 2019; Feb 8.

Hong H, Chen C, Kim D, Machtei E. Ridge preservation procedures revisited: A randomized controlled trial to evaluate dimensional changes with two different surgical protocols. Journal of Periodontology 2018; Oct 27.

Howait M, Albassam A, Yamada C, Sasaki H, Bahammam L, Azuma M, Cintra L, Satoskar A, Yamada S, White R, Kawai T, Movila A. Elevated expression of macrophage migration inhibitory factor promotes inflammatory bone resorption induced in a mouse model of periradicular periodontitis. Journal of Immunology 2019; Feb 8.

Montero E, Herrera D, Sanz M, Dhir S, Van Dyke T, Sima C. Development and validation of a predictive model for periodontitis using NHANES 2011-2012 data. Journal of Clinical Periodontology 2019; Mar 19.

Pampena E, Vanucci R, Johnson L, Bind M, Tamayo I, Welch K, Lind E, Wagner R, Villa A. Educational interventions on human papillomavirus for oral health providers. Journal of Cancer Education 2019; Mar 13.

Sasaki H, Furusho H, Rider D, Dobeck J, Kuo W, Fujimura A, Yoganathan S, Hirai K, Xu S, Sasaki K, Stashenko P. Endodontic infection-induced inflammation resembling osteomyelitis of the jaws in toll-like receptor 2/interleukin 10 double-knockout mice. Journal of Endodontics 2019;45(2):181-188.

Sima C, Paster B, Van Dyke T. Function of pro-resolving lipid mediator resolvin E1 in type 2 diabetes. Critical Reviews in Immunology 2018;38(5):343-365.

Wang F, Tarkkonen K, Nieminen-Pihala V, Nagano K, Majidi R, Puolakkainen T, Rummukainen P, Lehto J, Roivainen A, Zhang F, Mäkitie O, Baron R, Kiviranta R. Mesenchymal cell-derived juxtacrine Wnt1 signaling regulates osteoblast activity and osteoclast differentiation. Journal of Bone and Mineral Research 2019; Jan 28.

Woo SB. Oral epithelial dysplasia and premalignancy. Head and Neck Pathology 2019; Mar 18.

Yang G, Wang J, Lu S, Chen Z, Fan S, Chen D, Xue H, Shi W, He J. Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action. British Journal of Pharmacology 2019; Mar 30.

Zhao Q, Wang S, Xu G, Song Y, Han X, Liu Z, Zhou X, Zhang T, Huang K, Yang T, Lin Y, Wu S, Wang Z, Wang C. Periodontal health: A national cross-sectional study of knowledge, attitudes and practices for the public oral health strategy in China. Journal of Clinical Periodontology 2019; Feb 15.

publications continued on page 6

HSDM PUBLICATIONS DEVELOPMENTAL BIOLOGYAlikhani M, Alikhani M, Alansari S, Almansour A, Hamidaddin M, Khoo E, Lopez J, Nervina J, Nho J, Oliveira S, Sangsuwon C, Teixeira C. Therapeutic effect of localized vibration on alveolar bone of osteoporotic rats. PLoS One 2019;14(1):e0211004.

Cong Q, Xu R, Yang Y. Gαs signaling in skeletal development, homeostasis and diseases. Current Topics in Developmental Biology 2019;133:281-307.

Fuente R, Gil-Peña H, Claramunt-Taberner D, Hernández-Frías O, Fernández-Iglesias Á, Alonso-Durán L, Rodríguez-Rubio E, Hermida-Prado F, Anes-González G, Rubio-Aliaga I, Wagner C, Santos F. MAPK inhibition and growth hormone: A promising therapy in XLH. FASEB Journal 2019; Apr 11.

Jacox L, Mihas P, Cho C, Lin F, Ko C. Understanding technology adoption by orthodontists: A qualitative study. American Journal of Orthodontics and Dentofacial Orthopedics 2019;155(3):432-42.

Lyons K, Rosen V. BMPs, TGFβ, and border security at the interzone. Current Topics in Developmental Biology 2019;133:153-70.

Okubo M, Chiba R, Karakida T, Yamazaki H, Yamamoto R, Kobayashi S, Niwa T, Margolis H, Nagano T, Yamakoshi Y, Gomi K. Potential function of TGFβ isoforms in maturation-stage ameloblasts. Journal of Oral Bioscience 2019;61(1):43-54.

Olsen BR. Vertebrate skeletal development (Preface). Current Topics in Developmental Biology 2019;133:1-6.

Salazar V, Capelo L, Cantù C, Zimmerli D, Gosalia N, Pregizer S, Cox K, Ohte S, Feigenson M, Gamer L, Nyman J, Carey D, Economides A, Basler K, Rosen V. Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche. Elife 2019; Feb 8.

Vasudavan S, Grunes B, Mcgeachie J, Sonis A. Antibiotic prescribing patterns among dental professionals in Massachusetts. Pediatric Dentistry 2019;15;41(1):25-30.

Yamazaki H, Tran B, Beniash E, Kwak S, Margolis H. Proteolysis by MMP20 prevents aberrant mineralization in secretory enamel. Journal of Dental Research 2019; Feb 11.

ORAL MEDICINE, INFECTION AND IMMUNITYAddison W, Hall K, Kokabu S, Matsubara T, Fu M, Gori F, Baron R. Zfp423 regulates skeletal muscle regeneration and proliferation. Molecular Cell Biology 2019; Jan 28.

Ames N, Barb J, Ranucci A, Kim H, Mudra S, Cashion A, Townsley D, Childs R, Paster B, Faller L, Wallen G. The oral microbiome of patients undergoing treatment for severe aplastic anemia. Annals of Hematology 2019; Mar 27.

Barquera B. The antibiotic korormicin A kills bacteria by producing reactive oxygen species. Maynard A, Butler N, Ito T, da Silva A, Murai M, Chen T, Koffas M, Miyoshi H, Journal of Bacteriology 2019; Mar 11. Bor B, Bedree J, Shi W, McLean J, He X. Saccharibacteria(TM7) in the human oral microbiome. Journal of Dental Research 2019; Mar 20.

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HSDM RESEARCH DAY

Dental Public Health Residents, Dr. Jevae Nelson, MMSc19, has been awarded first place and Dr. Muath Aldosari, DMSc20, has been awarded third place for the Leverett Graduate Student Merit Award for Outstanding Achievement in Dental Public Health. Dr. Erinne Kennedy, MMSc19 and Dr. Kobie Gordon, MMSc21, were selected as the 2019 recipients of the AAPHD Foundation Herschel S. Horowitz Scholarship. Of special note, Mary Tavares, DMD, MPH, has been sworn in as the President of the American Association of Public Health Dentists and Brittany Seymour, DDS, MPH, as Secretary. Photo: Drs. Jevae Nelson, Muath Aldosari, Erinne Kennedy and Kobie Gordon.

Hend Alqaderi, BDS, DMSc, lecturer on oral health policy and epidemiology, received a grant from the Kuwait Foundation for Advancement of Science entitled, “Kuwait Healthy Life Study (Phase 2): A longitudinal study to identify salivary biomarkers of metabolic

syndrome in Kuwaiti adolescents.” Alqaderi is working with Drs. Mary Tavares and Max Goodson at the Forsyth Institute and Dr. Fahad Al-Mulla at Dasaman Diabetes Institute in Kuwait. Photo: Drs. Max Goodson, Mary Tavares, Hend Alqaderi and Pramod Soparkar.

Alessandro Villa, DDS, PhD, MPH, assistant professor of oral medicine, infection and immunity, received a grant from DentaQuest to support the second year of the Fellowship in Oral Medicine and Oral Oncology. This year-long, full-time program provides in-depth training for dentists interested in the dental management of cancer patients.

Sicong Li, DMD19 with Dr. Xhenhua Gao

Puhan He, DMD19 with Dr. Jeff Shaefer

Deepti Karhade, DMD19 with Dr. Francesca Gori

& AWARDS

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Dr. Bjorn R. Olsen receiving the 2019 King Faisal Prize in Medicine from King Salman bin Abdulaziz Al-Saud, Patron of the King Faisal Foundation.

Dr. Paul Sharpe presented, “Dental Pulp Stem Cells: A tractable model to understand stem cell behavior and develop novel biologically-based dental therapies” as the recipient of the 2018 Paul Goldhaber Award. Photo: Dr. Bruce Donoff, Dr. Samuel Goldhaber, Dr. Paul Sharpe and Mrs. Reeve Goldhaber.

Michael Baron, DMD20, receiving the American Dental Association/Dentsply Student Clinician Research Program Award from Mr. Joel Monteiro from Dentsply Sirona. Baron’s project, “Oral and maxillofacial surgery chief residents’ perception of training deficits” is mentored by Dr. John Tannyhill, instructor in the Department of Oral and Maxillofacial Surgery.

Dr. Daniel Zlott presenting the 2019 Professor Donald B. Giddon Annual Lecture in Behavior Medicine and Dentistry, “Pharmacy’s future: What dentistry can learn from pharmacy’s experience.”

Dr. Jennifer Gibbs, assistant professor of restorative dentistry and biomaterials sciences with her postdoctoral fellow, Dr. Benoit Michot who presented, “Effects of calcitonin gene-related peptide on dental pulp stem cells viability, proliferation and differentiation into odontoblast.”

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A PUBLICATION OF THE OFFICE OF RESEARCH

188 Longwood Avenue, REB-404 – Boston, Massachusetts 02115 v

www.hsdm.harvard.edu – 617.432-1121 vv

Malcolm Whitman, PhD, Associate Dean for Basic Science

Yingzi Yang, PhD, Associate Dean for Translational Research

Dawn M. DeCosta, Editor and Layout

Heather M. Denny, Editing

Lia Sgourakes, Editing

Ashley Simmons, Editing and Photography

ORAL AND MAXILLOFACIAL SURGERY Dang R, Calabrese C, Burashed H, Doyle M, Vernacchio L, Resnick C. Craniofacial anthropometry: Normative data for caucasian infants. Journal of Craniofacial Surgery 2019; Mar 27.

Frid P, Resnick C, Abramowicz S, Stoustrup P, Nørholt S; Temporomandibular Joint Juvenile Arthritis Work Group TMJaw. Surgical correction of dentofacial deformities in juvenile idiopathic arthritis: A systematic literature review. International Journal of Oral and Maxillofacial Surgery 2019; Jan 28.

Gao Y, Zhou S, Luu S, Glowacki J. Megalin mediates 25-hydroxyvitamin D3 actions in human mesenchymal stem cells. FASEB Journal 2019; Mar 20.

Karhade D, Afshar S, Padwa B. What is the prevalence of undiagnosed nevoid basal cell carcinoma syndrome in children with an odontogenic keratocyst? Journal of Oral and Maxillofacial Surgery 2019; Feb 5. Kinard B, Hansen G, Newman M, Dennis P, Haeffs T, Perez S, Sakamoto H, Steed M, Hughes P, August M, Abramowicz S. How well do we manage the odontogenic keratocyst? A multicenter study. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2018; Dec 14.

Lowe B, Ottensmeyer M, Xu C, He Y, Ye Q, Troulis M. The regenerative applicability of bioactive glass and beta-tricalcium phosphate in bone tissue engineering: A transformation perspective. Journal of Functional Biomaterials 2019;10(1).

Resnick C. Pediatric sleep surgery: Skeletal procedures. Atlas Oral Maxillofacial Surgery Clinics of North America 2019;27(1):67-75.

Resnick C, Calabrese C, Afshar S, Padwa B. Do oral and maxillofacial surgeons over-prescribe opioids after extraction of asymptomatic third molars? Journal of Oral and Maxillofacial Surgery 2019; Feb 16.

Resnick C, Frid P, Norholt S, Stoustrup P, Peacock Z, Kaban L, Pedersen T, Abramowicz S; Temporomandibular joint juvenile arthritis (TMJaw) working group – Results of a multinational consensus conference. Journal of Oral and Maxillofacial Surgery 2019; Feb 21.

Wicheta S, Van der Groen T, Faquin W, August M. Discrepancies in interpretation of the minor salivary gland biopsy in the diagnosis of Sjögren Syndrome. Journal of Oral and Maxillofacial Surgery 2019; Feb 8.

ORAL HEALTH POLICY AND EPIDEMIOLOGYChoi S, Berkowitz S, Yudkin J, Naci H, Basu S. Personalizing second-line type 2 diabetes treatment selection: Combining network meta-analysis, individualized risk, and patient preferences for unified decision support. Medical Decision Making 2019; Feb 15.

Dung T, Ngoc V, Hiep N, Khoi T, Xiem V, Chu-Dinh T, Cieslar-Pobuda A, Stoufi E, Show P, Tao Y, Bac N, Van Ba N, Le Q, Pham V, Chu D. Evaluation of dental arch dimensions in 12 year-old Vietnamese children - A cross-sectional study of 4565 subjects. Science Reports 2019;9(1):3101.

Nelson S, Albert J, Liu Y, Selvaraj D, Curtan S, Ryan K, Pinto A, Ejaz F, Milgrom P, Riedy C. The psychometric properties of a new oral health illness perception measure for adults aged 62 years and older. PLoS One 2019;14(4):e0214082.

Nelson S, Milgrom P, Albert JM, Selvaraj D, Cunha-Cruz J, Curtan S, Copeland T, Heima M, Rothen M, Beck G, Ferretti G, Riedy C. Randomized trial based on the common-sense model of self-regulation to increase child dental visits. JDR Clinical and Translational Research 2019; Feb 22.

O’Brien K, Putney J, Collin C, Halmo R, Cadet T. Optimizing screening, brief intervention, and referral to treatment (SBIRT) training for nurses and social workers: Testing the added effect of online patient simulation. Substance Abuse 2019; Mar 18:1-5.

Simon L, Singh Dhaliwal G, Liu C, Sharma P, Thomas S, Bettag S, Weber K, Timothé P, Nalliah R. Characteristics of patients discontinuing care. Dentistry Journal 2019;28;7(2).

Thompson L, Jiang T, Savageau J, Silk H, Riedy C. An assessment of oral health training among geriatric fellowship programs: A national survey. Journal of the American Geriatric Society 2019; Jan 29.

Yansane A, Tokede O, White J, Etolue J, McClellan L, Walji M, Obadan-Udoh E, Kalenderian E. Utilization and validity of the dental diagnostic system over time in academic and private practice. JDR Clinical and Translational Research 2019;4(2):143-150.

MULTI-DEPARTMENTALHamilton A, Jamjoom F, Doliveux S, Gallucci G, Friedland B. Radiographic markers for merging virtual data sets. Journal of Prosthetic Dentistry 2019; 3913(18)30675-30679.

Kong X, Liu J, Chien T, Batalden M, Hirsh D. A systematic network of autism primary care services (SYNAPSE): A model of coproduction for the management of autism spectrum disorder. Journal of Autism Developmental Disorders 2019; Feb 21.

Nojiri T, Chen C, Kim D, Da Silva J, Lee C, Maeno M, McClelland A, Tse B, Ishikawa-Nagai S, Hatakeyama W, Kondo H, Nagai M. Establishment of perpendicular protrusion of type I collagen on TiO2 nanotube surface as a priming site of peri-implant connective fibers. Journal of Nanobiotechnology 20191;17(1):34.

Tokede O, Levine S. Periodontal health and orthodontic treatment. Journal of the American Dental Association 2019;150(2):85-86.

Zhang B, Yang Y, Keyimu R, Hao J, Zhao Z, Ye R. The role of lamin A/C in mesenchymal stem cell differentiation. Journal of Physiology Biochemistry 2019; Jan 31.

SCIENCEMAY 8, 2019 • 11AM-12PM

HSDM REB AUDITORIUM • 190 LONGWOOD AVENUE

CLIFFORD J. ROSEN, MD

SPEAKER SERIES

Senior Scientist; Director, Center for Clinical & Translational ResearchMaine Medical Center Research Institute

"Exercise and the Skeleton: What's with Irisin?"