DIVERSIFY YOUR QUALITY - Bestpharmabestpharma.pl/resources/dokumenty/bestpharma_catalogue_final-web.pdf · DIVERSIFY YOUR QUALITY. Bestpharma was founded in pursuit of excellence

Pharmaceutical& nutraceuticalingredients

DIVERSIFYYOUR QUALITY

Bestpharma was founded in pursuit of excellence. By focusing all of

our attention on the customers' needs and by meeting all their

expectations we were able to stabilize our position and have gained

the trust of major manufacturers of pharmaceuticals and dietary

supplements in Poland.

At Bestpharma we believe that high quality shouldn't be

accompanied by high prices. Thanks to diversifying our suppliers and

effective negotiation, we deliver highest quality products sustaining

reasonable prices. The quality of customer relations is also one of the

reasons why companies choose us as a partner. We work with the

customer to best fit his needs and meet his expectations.

Bestpharma supplies and distributes standard pharmaceutical

ingredients as well as specialized products. Our Pharma-targeted

approach obligates us to take very restrictive measures in quality

assessment of our products and constant engagement in customer

relations. We are well aware that in many cases the well-being of

patients undergoing pharmaceutical treatment and dietary

supplements consumers depends on our professionalism. This is why

we give all the attention to deliver repeatedly reliable quality (RRQ)

We are a dynamic company with a stable position on the polish

pharmaceutical and nutraceutical ingredients market. Thanks to

intense R&D efforts, we’ve lately released our own product, BestCoat

film coating systems which is being produced in Poland. Our goal is

expansion on both Polish and European markets. Our team devotes

itself to building strong and both ways beneficial relationships with

customers. This is why we based our trade and distribution structure

on observance of the law and ethics in trading by always fulfilling

commitments we undertake.

The catalog you are holding represents the effects of a successful cooperation with our customers.Please note, we are always open to new assignments and challenges. If the

desired product cannot be found in this catalogue, please contact us at:

[email protected] We will do our best to help.

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06 Bestpharma ExcipientsQuality IS ESSENTIAL

12 Bestpharma NaturalNATURAL EXTRACTof the world

20 Bestpharma ProBioANAEROBIC PROBIOTICSThe next step in gut health

28 Bestpharma MarineNATURAL MARINE and PLANT OILSand Omega 3 products

36 Bestpharma BestCoatInnovative Film Coating SystemsFOR FOOD AND PHARMA

TABLE OFCONTENTS

5

Bestpharma

ExcipientsExcipients

6

EXCIPIENTS

Excipients are pharmacologically inactive substances formulated with the

active ingredient (API) of a medication. They are commonly used to bulk up

formulations that contain potent active ingredients (thus often referred to as

"bulking agents," "fillers," or "diluents"), to allow convenient and accurate

dispensation of a drug substance when producing a dosage form. They also can

serve various therapeutic-enhancing purposes, such as facilitating drug

absorption or solubility, or other pharmacokinetic considerations. Excipients

can also be useful in the manufacturing process, to aid in the handling of the

active substance concerned such as by facilitating powder flowability or

non-stick properties, in addition to aiding in vitro stability such as prevention of

denaturation over the expected shelf life. The selection of appropriate

e0xcipients also depends upon the route of administration and the dosage

form, as well as the active ingredient and other factors.

At Bestpharma we believe that the key to a successful formulation is a high

standard and repeatable high quality. This is why we are proud to introduce our

state-of-the art excipients:

BESTCEL - Microcrystalline cellulose,

Magnesium Stearate

PHARMELLOSE - Croscarmellose Sodium

Pregelatinized Starch 1500

7

PRODUCT GRADE

GRADE PARTICLE SIZE DISTRI BUTION

D10(MIC)

D10(MIC)

D10(MIC)

ASP#(MIC)

BULKDENSITY(GM/ML)

MOISTURE(% W/W)

DOP##

DESCRIPTION

BESTCEL-101*

BESTCEL-102*

BESTCEL-103BESTCEL-112BESTCEL-113

BESTCEL-105

BESTCEL-200

BESTCEL-301

BESTCEL-302

BESTCEL-N

Most widely used for direct compression tableting and wet granulation.

Has similar compression properties to BESTCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders.

Reduce moisture content and are ideal for use with moisture sensitive materials.

Has the finest particle size and may be used in direct compressin of coarser, granular and crystalline materials. BESTCEL-105's enhanced compressibility characteristics make it ideally suitable for application involving difficult to compress materials. It can be admixed with BESTCEL-101 or BESTCEL-102 to achieve specific flow and/or compression properties.

Has a large particle size which offers increased flow ability with minimum effect on compression characteristics. It can be used in direct compression and wet granulation to reduce table weight variation and to improve content uniformity.

Has a higher density then its size equivalent, BESTCEL-101, providing increased flow ability, greater tablet weight uniformity and the potential for making smaller tablets.

Has the density characteristics of BESTCEL-301 with a particle size of BESTCEL-102. Like BESTCEL-301, BESTCEL-302 offers increased flow ability, greater tablet weight uniformity and the potential for smaller tablets.

Is most widely used for wet granulation.

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BESTCEL-101BESTCEL-102BESTCEL-103BESTCEL-105BESTCEL-112BESTCEL-113BESTCEL-200BESTCEL-301BESTCEL-302BESTCEL-N*

NMT 30

NMT 45

NMT 30

—

NMT 45

NMT 30

NMT 70

NMT 30

NMT 45

NMT 30

40-60

70-100

40-60

—

70-100

40-60

150-200

40-60

70-100

40-60

NLT 80

NLT 140

NLT 80

—

NLT 140

NLT 80

NLT 260

NLT 80

NLT 140

NLT 80

50

90

50

20

90

50

180

50

90

50

0.26-0.32

0.27-0.33

0.26-0.31

0.20-0.30

0.28-0.35

0.26-0.34

0.31-0.39

0.34-0.45

0.35-0.46

0.25-0.45

3.0-5.0

3.0-5.0

1.0-3.0

1.0-5.0

0.0-5.0

0.0-1.5

0.0-2.0

3.0-5.0

3.0-5.0

NMT 5.0

200-250

200-250

200-250

200-250

200-250

200-250

200-250

130-180

130-180

200-250

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*BECTCEL 101 and 102 are in stock throughout the whole year in our warehouse in Warsaw.

* Non-direct compressible grade BESTCEL-MCC# Average Particle Size, ## Degree of Polymerization, NMT : Not more than, NLT : Not less than, MIC : Micron

BESTCELLMICROCRYSTALLINE CELLULOSE

PROPERTIES OF DIFFERENT BESTCEL GRADES:

8

MAGNESIUM STEARATE

It has the chemical formula Mg(C18H35O2)2. It is a salt containing two

equivalents of Stearate (the anion of Stearic Acid and one Magnesium

cation (Mg2+). Magnesium Stearate melts at about 120 °C, is not

soluble in water, and is generally considered safe for human

consumption at levels below 2500 mg/kg per day. Magnesium Stearate

is often used as a diluent in the manufacture of medical tablets,

capsules and powders. In this regard, the substance is also useful,

because it has lubricating properties, preventing ingredients from

sticking to manufacturing equipment during the compression of

chemical powders into solid tablets; magnesium stearate is the most

commonly used lubricant for tablets.

Benefits of Bestpharma Magnesium Stearate:

It is an inactive ingredient that binds the active ingredient in a pill or capsule

The FDA classifies Magnesium Stearate as a glidant, or granulating agent.

Magnesium Stearate functions in medicine by preventing the different molecules used to make up the medicine from clumping together, thus ensuring that the correct dose is achieved in every pill made.

It is added to supplements to increase production speed as the machines fill the supplement capsules.

As an excipient, Magnesium Stearate helps to prolong the shelf life of pharmaceuticals and masks the taste and odour of active ingredients.

9

PHARMELLOSECROSSCARMELLOSE SODIUM

Croscarmellose sodium is an internally cross-linked sodium

carboxymethylcellulose for use as a superdisintegrant in

pharmaceutical formulations. It’s cross-linking reduces water solubility

while still allowing the material to swell (like a sponge) and absorb

many times its weight in water. As a result, it provides superior drug

dissolution and disintegration characteristics, thus improving formulas

subsequent bioavailability by bringing the active ingredients into better

contact with bodily fluids. Croscarmellose sodium also resolves

formulators concerns over long-term functional stability, reduced

effectiveness at high tablet hardness levels, and similar problems

associated with other products developed to enhance drug dissolution.

Croscarmellose sodium is a very commonly used pharmaceutical

additive approved by the European Food Safety Authority (EFSA). Its

purpose in most tablets – including dietary supplements – is to assist

the tablet in disintegrating in the intestinal tract at the required

location. If a tablet disintegrating agent is not included, the tablet could

disintegrate too slowly, in the wrong part of the intestine or not at all,

thereby reducing the efficacy and bioavailability of the active

ingredients.

Benefits of Bestpharma’s PHARMELLOSE Crosscarmellose Sodium:

Rapid disintegrator in pharmaceutical formulations for tablets, capsules and granules.

Effective for combination with both insoluble and filler-binders, such as MCC and DCP.

It can also be preferred for non starch base formulation product.

Tablet dissolution can be greatly increased by the use of a super disintegrant.

Efficient for low use of levels.

Insensate hardness of tablet.

Finer dissolution stability for long term.

Used in solid dosages vitamin and nutrition.

10

PREGELATINIZEDSTARCH 1500Starches are used in the pharmaceutical industry for a wide variety of

reasons, such as an excipient, a tablet and capsule diluent, a tablet and

capsule disintegrant, a glidant, or as binder. Disintegrants enable

tablets and capsules to break down into smaller fragments (dissolve) so

that the drug can be released for absorption. Starches also absorb

water rapidly, allowing tablets to disintegrate appropriately.

Pregelatinized Starch 1500 Conforms to USP27 standards.

Character: White powders, no smell, tasteless, insoluble in Organic solvents, parts dissoluble in cold water.

Particle size: 100 percent through 80 mesh sieve.

pH

Loss on drying [%]

Ash [%]

Iron [%]

Sulfur dioxide [%]

Oxide [%]

4.5-7.0

≤14.0

≤0.5

≤0.002

≤0.008

≤0.002

PHYSICAL PROPERTIES:

I T E M S P E C I F I C A T I O N ( U S P 2 7 )

11

Bestpharma

NaturalNatural

12

NATURAL EXTRACTS

Natural extracts are ingredients derived from natural sources, mostly plants,

but also fungi, insects or animals. Plant extracts divide into flower, fruit, root,

bark derived and others depending on the functional substances in them.

Among others, flavonoids, saponins, tannins, essential oils, mucus and

vitamins were proven to have functional properties for the human organism.

Natural extracts are very well used in the Food Industry as well as in

Pharmaceuticals.

Bestpharma supplies a wide range of natural extracts which originate from all

over the world. Below you will find a list of our offered products. If your desired

extract is not on the list, do not hesitate to contact us at

[email protected]. We can surely help.

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EXTR

AC

TSPLANT SOURCE BOTANICAL NAME SPECIFICATION

5-HTP

Acai Berry

Acerola Cherry

Achyranthes aspera

Astaxanthin

Akebia Stern

Alisma orientale

Aloe Vera

American Ginseng

Amorni Semen

Andrographis

Angelica polydada

Apple

Artichoke

Asarum

Astragalus

Avena Sativa

Bamboo Leaf

Basket fern

Bayberry

Beta Carotene

Bistort Rhizome

Bitter melon

Black Bean

Black Cohosh

Black Fungus

Black Pepper

Black Tea

Blackcurrant

Black Rice

Bladderwrack

Blueberry

Bran Oil

Broccoli

Bromelain

Buckwheat

Bupleurum

Burdock

Cactus

Calyx Kaki

Griffon ia simplicifolia

Euterpe badiocarpa.L

M alp ighia glabra L.

Achyranthes aspera L

Haematococcus pluvialis

Akebia trifotiata ( Thunb. >

Alisma o rien talis (Sam.)

Aloe vera L.

Panax quinguefoiium

Amomum viltosum Lour

Andrographis paniculate

Notopterygium incisum Ting

Mains Pumila

Cynara Scolymus

Asarum sieboldii Miq.

Astragalus Membranaceus

Avena sativa L.

Phyilostachys nigra Munro var.

Cyrtomium fortunei J. Sm.

Myrica rubra (L our,}

Carrot

Polygonum bistorta L .

Momordica charantia L

Glycine max(L.) Merr.

Cimicifuga racemosa

Auricularia auricula

Piper nigrum I.

Camellia sinensis O. Ktze.

Ribes nigrum L.

Oryza satiual

Fucus vesiculosusL.

Vaccinium Spp.

Bran oil

Brassica Oleracea

Ananas comosus

Fagopyrum Mill

Radix Bupteuri

Arctium lappa L

Opuntiadillenii

Diospyros kaki L f.

20%, 98%, 99% 5-HTP

l-25% Anthocyanidins, 10:l, 20:l

17% VC

10:1, 20:1

2-10% Astaxanthin

10:1, 20:1

10:1, 20:1

10:l, 25:l, 100:l, 200:l (Spray Dried or Freeze Dried)

10%-80% Ginsenosides

10:1, 20:1 10-95% Andrographolides, 8%

Dehydroandrographolide

10:1, 20:1

10%-80% Polyphenols, 20%-98% Phloridzin

2.5%,5% Cynarine, 10:l

10:1, 20:1

50-70% Polysaccharides, 5-98% Astragaloside IV

60%, 70% Beta Glucans

10%, 15%, 24% Bamboo flavone, 10:l

10:1,20:1

10:1,20:1

1-96% Beta Cartotine

10:1,20:1

10-80% Charantin/10%,20% Sapogenins, 10:1

5%,10%,15% Anthocyanidins

2.5%,5% Triterpene Glycosides

10%-40% Polysaccharides

20:1

20%-60% Theaflavine, 20%-90% Polyphenols

l%-25% Anthocyanidins,10:l,20:l

l%-25% Anthocyanidins,10:l,20:l

0.1% Iodine

1-36% Anthocyanidins

99% Oryzanol

0.6%,10%,20% Sulforaphane

2500GDU/g

10:1,20:1,5% D-Chiro Inositol

10:1

10:1,20:1

10:1,20:1,100:1

10:1,20:1

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EXTR

AC


Cat's Claw

Catgrass

Cayenne

Celery

Celery Seed

Chamomile

Chaste Berry

Chaste Tree

China Dodder

Chinese angelica

Chinese Bilberry

Chinese catalpa bark

Chinese Foxglove

Chinese White Olive

Chinese yam

Chokeberrry

Chondroitin Sulfate

Chrysanthemum

Cinnamon

Citus Aurantium

Cleavers

Cloves

Cocoa

Coix Seed

Common Cnidium Fruit

Common Leafflower Herb

Coprinus Comatus

Coptis

Cordyceps

Conolus Mushroom

Corn Silk

Corydalis bungeana

Cranberry

Curcumin

Dandelion

Desertliving Cistanche

Devil's Claw

Ecdysone

Echinacea Angustifolia

Echinacea Purpurea

Uncaria Tomentosa

Agropyron cristatum

Capsicum annuum Linn

Apium graveoiens

Apium graveotens

Matricaria Recutita

Vitex agnus-castus Linn.

Vitex Agnus Castus

Cuscuta chinensis Lam.

Angelica Sinensis

Vaccinium uliginosum

Cataipa Ovata G.Don

Rehmannia giutinosa

Canarium album Raeusch.

Dioscorea opposita

Aronia nwianocarpa

Bovine Ca/tttage

Dendranthema niorifolium

Cortex Cinnamomi Cassiae

Citrus Aurantium

Galium aparine L.

Syzygium aromaticum

Theobroma Cacao

Semen Coicis

Cnidium monnieri (L.)

Phyltanthus urina-ria L.

Coprinus Comatus

Coptis chinensis Franch

Cordyceps sinensis

Coriotus versicolor

Zeamays L.

Co/ydalis bungeana Turcz.

Vaccinium macrocarpon.

Curcumin Longa

Taraxaci Officinale

Cistanche deserticola Ma

Harpagophytum Procumbens

Cyanotis arachnoisea

Echinacea Angustofolia

Echinacea Purpurea

3% Alkaloids

10:1,20:1

10:1,20:1

10:1,20:1

10:1,20:1

1% Total Apigenins

0.5% Agnusides

5% Vitexin,2% Agnuside

10:1,20:1

1% Ligustilides


10:1,20:1

10:1,20:1

10:1,20:1

8%,16%,95% Diosgenine,10:l,20:l

10-25% Anthocyanidins,10:l,20:l

90% Chondroitin Sulfate

0.8% Lactone,10:l,15:l,20:l

10:1,20:1

6-98%Synepherine

10:1,20:1

4:1,10:1

10:1,20:1

10:1,20:1

20%,30%,50%,90%,98% Osthole

10:1,20:1


5%,10% Alkaloids

10-40% Polysaccharides


10:1,20:1

10:1,20:1

l-36%Anthocyanidins,10:l,20:l,34:l,36:l

95% Curcumin

20% Taraxasterols,3% Flavonoids

10:1,20:1

1.5%, 3% Harpagosides

90%,95%,98% Ecdysone

4% Echinacosides

4% Phenolics.2%,4% Cichoric Acid

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EXTR

AC


Elderberry

Elecampane

Emodin

Eucommia Bark Liquid

Eucommia Leaf

European Bilberry

Eurycoma Longifolia

Evening Primrose

Evodia

Fennel Seed

Fenugreek Seed

Ferulic Acid

Feverfew

Fig

Flaxseed

Flos Inulae

Forskohlin

Fo-Ti

Frankincense

French Maritime Pine Bark

Fructus Chaenomelis

Fructus Mori

Galanthamine

Gallnuts

Garcinia Cambogia

Gardenia

Garlic

Gastrodia Tuber

Ginger

Ginkgo FJiloba

Ginseng

Glabrous GreenbrierRhizome

Glucomannan

Goji Berry

Golden Rod

Goldenseal

Gotu Kola

Grape Seed

Grape Skin

Sambucus nigra L

Inula helenium L

Polygonum Cuspidatum

Eucommia Utmoids Otiv.

Eucommia Ulmoids Otiv.

Vaccinium Myrtilius

Eurycoma Longifolia

Oenothera erythrosepala Sorb.

Evodia Rutaecarpa

Fo eniculi Fructus

Semen Trigoneltae

Ferula assafoetida L.

Tanaceum parhenium

Ficus carica Linn.

Linum usitatissimum

inula britannica L

Coleus Forskohlii

Polygonum multlflorum Thunb

Bosweltia carteriiBirdw.

Pinus pinaster

Chaenomeles sinensis Koehne

Morus alba L

Lycoris radiata

Gallnuts

Garcinia Hanburyi

Gardeniajasminotdes Fills

Allium Sativum L

Gastrodia eiata

Zingiber Officinale

Ginkgo Btloba

Panax Genseng

Smitax glabra Roxb.

Amorphophaittus Konjac

Lyclum Chlnense

Solidago decurrens Lour

Hydrastis canadensis

Centetla As tat tea

Vttls Vtnlfera

Vitis Vintfera

10:1,20:1,5% Anthocyanidins

10:1,20:1

98% Emodin

Brix65

5-98% Chlorogenic Acid,10:l,20:l


25:1,50:1,100:1,200:1

10:1,20:1

10% Evodiamines, 10:1,20:1

15:1

10%-50% Saponins,l%,5%,10%,20%4-Hydroxyisoleucine

98% Ferulic Acid

0.8% Pharthenolide

10:1,20:1

20%-80% Lignans (SDG)

10:1,20:1

10%,20%,98% Forskohlin

2% Phosphatide,10:l,20:l

10:1,20:1

95% Proanthocyanidins

10:1,20:1

10:1,20:1

98% Galanthamine Hydrobrmide

85%,90% Gallic Acid,85%,92% Tannic Acid

50% Hydroxycitric Acid

50%,85%,90% Geniposide,10:l,20:l

0.5%,l%,2%Allicin,10:l,20:l

10:1,20:1

5% Gingerols

24% Flavonol Glycosides/6% Terpenelactones

25%,30%,35%,80% Ginsenosides

10:1,20:1

90% Glucomannan

15%,30%Polysaccharides,10:l,20:l

5% Flavonoids

5%, 10% Alkaloids

10%,20%,80% Triterpenoids, TECA 95%

95% Proanthocyanidins,95% Polyphenols

20%,25%,30% Polyphenols

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EXTR

AC


Grassleaf Sweelflag

Green Tea

Gromwell Root

Gymnemic Acids

Gyn ostein ma

Hawthorn Berry

Hawthorn Leaf

Heartsease

Herba Aqastachis

Herba Geran

Herba Leonuri

Herba Loophatheri

Herba Taxilli

Herba violae

Hesperidin

Hibiscus Flower

Honey Goat Weed

Honey Suckle Flower

Hops

Horehound

Horse Chestnut

Horsetail

Huperzine A

Hydrangeu Root

India Madder Root

Inulin

Irvingia Gabonensis Seed

Jujube

Kelp

Kidney Bean

Kiwifruit

Kudzu

Larqeleaf Gentian Root

Lemon Balm

Ligustrum

Lingonberry(Cowberry)

Loquat Leaf

Lotus Leaf

L-Theanine

Luffa sponge

Acorus tatarlnowiiSchott

Camellia Sinensis

Amebic euchroma

Gymnema syivestre 1

Gynostemma pentaphyllum

Crataegus pinnatlfida Bge.

Crataegus pinnatlfida Bge.

Viola trtcoto r L Inn.

Agastache rugosus

Geranium wilfordli Maxim.

Leonurusjaponicus Houtt.

Lophatherumgraclle Bongn.

Taxittus chinensts (DC.)

Violayedoensis Makino

Citrus Sinests

Hibiscus rosa sinensis

Epimedium Grandiftorum

L onicera Japonica

Hamulus iupuius

Lagopsis supina

Aescutus Hippocastanum

Equisetum Arvense

Huperzia Serrata

Hydrangea strigosa Rehd.

Rubia cordifolia L.

Gchorium intybus L

Irvingia gabonensis

Ziziphus Jujuba

Zostera Marina L.

Phaseolus Vulgaris

Fructus Actinidiae chinensis

Pueraria Lobata

Gentiana macrophytta Pall.

Melissa Officinalis

ligustrum tucidum Ait.

Vaccinlumvltis-idaea

Eriobotryajdponica

Nelumbo nucifera Gaertn.

Camellia Sinensis

Luffa cylindrica (L.J Roem.

10:1,20:1

20%-99% Polyphenol5,10-99% EGCG

30%,50%,98% Shikonin,10:l

25%,75% Gymnemic Acids

20%,80%,98% Gypenosides

10:1,15-30% Polysaccharides

2% Hyperosides, 1.8% Vitexin-2"-0-rhamnoside

10:1,20:1

10:1,20:1

10:1,20:1

10:1,20:1

5:1,10:1

10:1,20:1

15:1,30:1

98% Hesperidin

1%,2%,5% Anthocyanidins,10:l,20:l

5-98% Icarin

5-98% Chlorogenic Acid

10:l,20:l,3%Xanthohumol

10:1,20:1

20-90% Escin

2%,7% Silica acid, 10:1,20:1

1%,5%,98% Huperzine A

10:1,20:1

10:1,20:1

90% Inulin

10:1,20:1,5% Flavones

2% Jujuboside

5% Fucoxanthin

1-2% Phaseolin

10:1,20:1

40% Isoflavones,30%,98% Puerarin

10:1,20:1

2.5-10% Rosemarinic Acid, 10:1

10-98% Oleanolic Acid 10-35% Oligomeric,Proanthocyanidines(OPC),

5-25% Anthocyanins 10:1,20:1,10-98% Oleanolic Acid,

25%,90%,98%Ursolic Acid

10:l,20:l,5%-20%Flavones,l-50%Nuciferine

98% L-Theanine

10:1,20:1

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15917

EXTR

AC


Luo Han Guo

Lycopene

Maca

Magnolia Bark

Maitake mushroom

Malabar spinach

Marigold

Marsh Mallow

Milk Thistle

Mistletoe

Morindda Root

Mangosteen

Mucuna

Mulberry

Maringin

Needle Mushroom

Nettle

Notoqinsenq

Nutmeg

Octocosanol

Olive Leaf

Padiaxel

Passion Flower

Papain

Peppermint

Perilla Leaf

Perilla Seed

Phytosterols

Pine Bark

Plantain

Plantain Seed

Polyqala

Pomegranate Rind

Pomegranate Seed

Propolis

Pu ErTea

Pumpkin Seed

Purple Corn

Purple Sweet Potato

Quercetin

Momordica Grosvenori Swingle

Lycopersicon Esculentum

L epidium meyenii

Magnoliae Officinalis

Grifola frondo sus

Gynura cusimbua (D. Don) S. Moore

Tagetes erecta

Althaea officinalis L

Silybum Marianum

Scurrutap arasiticus

Morinda officinalis How

Garcinia Mangostana.L

Mucuna Pruriens

Moms alba L

Citrus Parodist

Elammultna velutipes

Urtica Dioeca

Panax notoginseng

Myristica fragrans Houtt.

Rice wax

Canarium album Raeusch.

Taxus chinensis

Passiflora Incarnota

Chaenomeles sinensis Koehne

Mentha hapio calyx

Perillafrutescens(L)Britt.

Perillafrutescens(L.)Britt.

Glycine max

Pinus Species

Plantago asiatica L

Plantago asiatica L

Polygala tenuifolia Wiltd.

Punica granatum L.

Punic agran alum L.

Propolis

Camellia sinensis O. Ktze.

Cucurbita Species

ZeaMayzl

Ipomoea batatas L

Sophora flavescens Ait.

5-99% Mogrosides/5-50% Mogroside V

5-20% Lycopene

0.5%,0.6% Macamides+Macaenes

10-98% Honokiol/Magnolol


10:1,20:1

5-90% Lutin,l-10% Zeaxanthin

10:1,20:1

80% Silymarin

10:1

40% Polysacchandes,10:l

10%,30%,90% a-Mangostin, 40%Polyphenols

15%,98%,99% L-Dopa

0.5-2% 1-DNJ

99% Naringin


1%, 2% Silicic Acid, 0.8% Total Sterols

10:1,20:1,5-98% Notoginsenosides

10:1,20:1

10-90% Octacosanol

16%, 18%,20%,30%,40% 01 europein

90-99% Pacliaxel

10:1,20:1,3.5%,4%,5% Total Flavones

1500TU/mg

10:1,20:1

10:1,20:1

10:1,20:1

95% Phytosterols

95% Proanthocyanidins

10:1,20:1

10:1,20:1

10:1,20:1

40% Ellagic Acid, 10:1,20:1

10:1,20:1

50%-98% Propolis

30% Polyphenols

15%, 25% Phytosterols,10:l,20:l



98% Quercetin

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18

EXTR

AC


Radix Adenophorae

Raspberry

Red Beet Root

Red Clover

Reishi Mushroom

Resveratrol

Rhizoma Anemarrhenae

Rhizoma Corydalis

Rhizoma Drynariae

Rhizoma Kaempferiae

Rhodiola Rosea

Rosemary

Royal jelly powder

Rutin

Saw Palmetto Berry

Schisandra

Scutellaria

Sea Buckthorn

Senna

Sesamin

Shikonin

Shitake mushroom

Siberian Ginseng

Soy Bean

St. John's Wort

Stevia

Straw Mushrrom

Sweetberry Honeysuckle

Sweet Wormwood Herb

Thunberg Fritillary

Tribulus

Uva Ursi

Valerian

Vietnamese Sophora Root

White Mulberry Root-bark

White Willow Bark

Wild Yam

Yerba Mate

Yohimbe

Adenophora stricta Miq ,

Fructus Rubi

Betavutgarisvar rubra

Trifolium Pratense

Ganderma Lucidum

Polygonum Cuspldatum

Anemarrhena asphodeioides Bge.

Co/ydalis yanhusuo W. T. Wang

Drynaria fortunei (Kunze )

Kaempferia gatanga L.

Rhodiola Rosea

Rosmarinus Officinalis

Royaljetly

Ruta graveolens L.

Serenoa Repens

Schizandra Chinensis

Scutellaria baicalensls George

Fructus Hippophae

Cassia Senna

Sesamum indicum

Arnebia euchroma

Lent inula edoder

Acanthopanax senticosus

Glycine max

Hypericum Perforatum

Ste via Rebaudiana

Volvarlella volvacea Sing.

Lonlcera caerulea L

Artemisia annua I.

Frititlaria thunbergii Miq.

Tribulus Terrestris

Arcotostaphylos Esculentu

Valeriana Officinalis

Sophora subprostrata Chun

Taxillus chinensis (DC.)

SalixAba

Dioscorea Vlttosa

Hex paraguarensis

Pausinystiiia Yohimbe

10:1,20:1

10:1,20:1

10% Betanin

2.5-60% Total Isoflavones


20%-99% Resveratrol

10:1,20:1

10:1,20:1

10:1,20:1

10:1,20:1

1-5% Rosavin,l-10% Salisorosides

5-50% Rosemarinic Acid

5%, 6% 10-HDA

95% Rutin

25% Fatty Acids/Phytosterols, 45% Fatty Acids

1-13% Schisandrins

30%,80%,95% Baicalin

10%-50% Flavones

10%,20% Sennosides

10-98% Sesamin

10-98% Shikonin


0.8%,1% Electherosides

10-90% Isoflavones,90% Saponin,99%Lecithin

0.3%,0.5% Hypericin

40-99% Steviosides,20-98%RA



98%,99% Arteannuin

10:1,20:1

20%-90% Saponins

10%,20% Arbutin,20%-98%Ursolic Acid

0.4%,0.8% Valerianc Acids

10:1,20:1

10:1,20:1

2.5%,10%,15%, 30%,98% Total Salicin

8%,16% Saponins

15% Polyphenols,10:l,20:l

2%,8% Yohimbines, 98% Yohimbine HCL

200

201

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19

Bestpharma

ProBioProBio

20

PROBIOTICS

There are about 400 types of intestinal microorganisms. There are more than

100 trillion intestinal microorganisms (cf: the number of cells in human body

is 60 trillion). They weigh about 1 kg per adult and form a characteristic flora in

the body depending on the person's age. However, our digestive system is in

jeopardy when the microorganism flora is disrupted due to the Western-style

diet containing high fat and high protein contents, excess stress, irregular life

style, lack of exercise and antibiotics.

21

Bestpharma is the exclusive partnerof BIFIDO Co., Ltd,a company dedicatedto research on human intestinal health.

BIFIDO CO., LTD.

BIFIDO Co., Ltd. Has been focusing on Bifidobacterium strains and for 20 years

in order to fully utilize science in nutritious and functional food materials for the

improvement of human health and well-being. They focus on basic research and

product development using probiotics. Among various probiotics,

Bifidobacterium is considered to be the most beneficial microorganism for the

maintenance of microbial balance in the intestinal tract.

Nowadays, Bifidobacterium and other lactic bacteria are being applied widely in

functional foods. BIFIDO is in the leading edge in the development of

human-health promoting Bifidobacterium.

22

R & D System

The BIFIDO Central Research Institute was

established for the purpose of finding

health-oriented new materials and promoting

health of human beings. The research results

of BIFIDO Co., Ltd. are applied to independent

business items ranged from high functional

food materials to new medicine development

that used the gene expression system,

through establishing efficient human

networks including the lab of the Food Science

and Nutrient Department at Seoul National

University, and exchanging openly with

exterior research teams.

As a proud exclusive partner, Bestpharma offers the following bacterial strains in bulk or in mixes,

as well as finished products with BIFIDO in-house formulations.

Main current R&D Projects are:

Development of allergy-suppressive Bifidobacterium

and Lactobacillus.

Development of rotavirus-inhibiting Bifidobacterium;

BORI protein, a novel rotavirus-inhibiting active

component, is in pending for patent in USA, Europe,

and Japan.

Development of tumor-suppressive Bifidobacterium;

chiro-inositol containing polysaccharide, a novel

tumor-suppressive active component, was

characterized.

Development of food-grade vectors for

Bifidobacterium.

23

HUMAN STUDIES

Irritable Bowel SyndromeEffect of Probiotics on Symptoms in Korean Adults with Irritable Bowel SyndromeGut and Liver, Vol.3, No.2. June 2009, pp. 101-107

Background/Aims:

Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of

probiotics reportedly exert remarkable immunomodulatory effects, and so

we designed a prospective double-blind randomized placebo-controlled

clinical study to assess their effects in Korean adults with IBS.

Methods:

IBS patients who met Rome III criteria were randomly assigned to receive

composite probiotics or placebo. A total of 20 billion lyophilized bacteria

were administered twice daily for 8 weeks. Primary outcome variables were

symptom scores consisting of abdominal pain, flatulence, defecation

discomfort, and sum of symptom scores. A visual analogue scale was used

to quantify the severity. Secondary outcome variables consisted of the

quality of life and bowel habits including defecation frequency and stool

form.

Results:

Thirty-six and 34 patients were randomized to the probiotics and placebo

groups, respectively. Intention to-treat analysis showed significant

reductions in pain after 8 weeks of treatment: −31.9 and −17.7 in the

probiotics and placebo groups, respectively (p=0.045). The reductions in

abdominal pain, defecation discomfort, and sum of scores were more

significant in 58 patients with a score of at least 3 on the baseline

stool-form scale. Conclusions: Composite probiotics containing

Bifdobacterium bifdum BGN4, Lactobacillus acidophilus AD031, and other

species are safe and effective, especially in patients who excrete normal or

loose stools.

24

Atopic DermatitisProbiotics in Primary Prevention of Atopic Dermatitis.Forum Nutr. Basel, Karger, 2009, vol 61, pp 117–128

Effect of probiotic mix (Bifidobacterium bifdum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial.

Controversy exists regarding the preventive effect of probiotics on the

development of eczema or atopic dermatitis. We investigated whether

supplementation of probiotics prevents the development of eczema in

infants at high risk. In a randomized, double-blind, placebo-controlled trial,

112 pregnant women with a family history of allergic diseases received a

once-daily supplement, either a mixture of Bifidobacterium bifidum BGN4,

B. lactis AD011, and Lactobacillus acidophilus AD031, or placebo, starting

at 4–8 wks before delivery and continuing until 6 months after delivery.

Infants were exclusively breast-fed during the first 3 months, and were

subsequently fed with breast milk or cow’s milk formula from 4 to 6 months

of age. Clinical symptoms of the infants were monitored until 1 yr of age,

when the total and specific IgE against common food allergens were

measured. A total of 68 infants completed the study. The prevalence of

eczema at 1 yr in the probiotic group was significantly lower than in the

placebo group (18.2% vs. 40.0%, p = 0.048). The cumulative incidence of

eczema during the first 12 months was reduced significantly in probiotic

group (36.4% vs. 62.9%, p = 0.029); however, there was no difference in

serum total IgE level or the sensitization against food allergens between the

two groups. Prenatal and postnatal supplementation with a mixture of B.

bifidum BGN4, B. lactis AD011, and L. acidophilus AD031 is an effective

approach in preventing the development of eczema in infants at high risk of

allergy during the first year of life.

HUMAN STUDIES

25

HUMAN STUDIES

Rotavirus infections

Sowha Children’s Hospital

We aimed to study the effect of lactic acid bacteria administration on patients with rotavirus gastroenteritis.

From December 2002 to September 2003, 57 patients with gastroenteritis(rotavirus passitive) under treatment in Sowha Children’s Hospital were divided into lactic acid bacteria administration group(28) and control group(29).

-Lactobacillus acidophilus, Bifidobacterium longum BORI and prebiotics (galacto-oligosaccharide etc.) were used. -Three days administration, 2 times per day, 2g for 1 time (contains L.acidophilus 2.0 X 108 CFU/g, B.longum BORI 2.0 X 109 CFU/g ).

Total days of emesis, times of emesis, times of diarrhea, total days of diarrhea; statistics analysis.

After administration of lactic acid bacteria, the decreased times of diarrhea

shows that lactic acid bacteria is beneficial for rotavirus gastroenteritis.

If more clinical research can be achieved in the future, the substitution

effect of lactic acid bacteria can be used to decrease the unnecessary

treatment of antidiarrheic and antibiotic for virus gastroenteritis.

Lactic acid bacteria ( – )

Lactic acid bacteria ( + )

Total days of diarrhea (day)

Total days of fever (day)

Times of diarrhea (time/day)

Total days of emesis (day)

26

PAPERCharacterization of a Bifidobacterium bifidum BORI

dipeptidase belonging to the U32 family.

Appl environ Microbiol. 2007 Sep; 73(17):5598-606

A dipeptidase was purified from a cell extract of

Bifidobacterium longum BORI by ammonium sulfate

precipitation and chromatography on DEAE-cellulose

and Q-Sepharose columns. The purified dipeptidase

had a molecular mass of about 49 kDa and was

optimally active at pH 8.0 and 50 degrees C. The

enzyme was a strict dipeptidase, being capable of

hydrolyzing a range of dipeptides but not tri- and

tetrapeptides, p-nitroanilide derivatives of amino

acids, or N- or C-terminus-blocked dipeptides.

A search of the amino acid sequence of an internal

tryptic fragment against protein sequences deduced

from the total genome sequence of B. longum

NCC2705 revealed that it was identical to an internal

sequence of the dipeptidase gene (pepD), which

comprised 1,602 nucleotides encoding 533 amino

acids with a molecular mass of 60 kDa, and thereby

differed considerably from the 49-kDa mass of the

purified dipeptidase. To understand this discrepancy,

pepD was cloned into an Escherichia coli expression

vector (pBAD-TOPO derivative) to generate the

recombinant plasmids pBAD-pepD and

pBAD-pepD-His (note that His in the plasmid

designation stands for a polyhistidine coding region).

Both plasmids were successfully expressed in E. coli,

and the recombinant protein PepD-His was purified

using nickel-chelating affinity chromatography and

reconfirmed by internal amino acid sequencing. The

PepD sequence was highly homologous to those of

the U34 family of peptidases, suggesting that the B.

longum BORI dipeptidase is a type of cysteine-type

N-terminal nucleophile hydrolase and has a

beta-hairpin

PATENTBifidobacterium bifidum BORI(AR81) enabling

inhibition of rotavirus and active protein separated

therefrom.

This invention is regarding the new bacterium that

inhibits rotavirus, which is known as a main source

that causes diarrhea and enteritis in young animals

such as an infant, cow, horse, pig and monkey, etc.,

and regarding the antirotavirus active protein that is

generated by this new Bifidobacterium longum

BORI(AR81).

27

Bestpharma

MarineMarine

28

MARINE

Omega 3 is a member of the Essential Fatty Acids family (EFA). Unsaturated

fatty acids can be divided into two categories, omega-6 EFA and omega-3 EFA,

including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

This last group of acids has a large influence on the human body (cardio-

vascular system, brain function, metabolic processes). DHA has a very

important role during human gestation and lactation.

In theory, a person should be able to synthesize omega-3 EPA and DHA from

dietary omega-3 ALA (alpha-linolenic acid – located in dark green vegetables).

In practice, this process is inefficient. Researchers concluded that omega-3 EPA

and DHA should be taken with food supplements. High quality of the fish oil

(mainly obtained from liver, flesh) is one of the sources of EPA and DHA omega-3

fatty acids. The oil can be mainly obtained from fish found in the cold waters of

the sea, such as tuna, salmon, anchovies, but also cod, shark, sardine.

Bestpharma offers the purest forms of Omega 3 oils supplied directly from the

manufacturers. Each manufacturer is carefully selected with regards to fishing

methods (from catch to processing), processing methods and lowest possible

oxidation levels. This enables us to supply the most fresh and highest quality

oil to our customers.

29

PUREFISH OILS:

COD LIVER OILAn oil obtained from livers of cods.This oil has a high level of omega-3 fatty acids. Cod liver oil

also contains vitamin A and vitamin D. It prevents:

decreases in immunity,

cardiac disorders,

maintains the correct level of cholesterol in states of impaired lipid metabolism.

SHARK LIVER OILIt has been used for centuries as a folk remedy to promote the healing of wounds and as a remedy for respiratory tract and digestive system problems.Shark liver oil is a rich source of alkylglycerols, chemicals

that may have anti-cancer properties. Other chemicals in

shark liver oil being studied against cancer are squalamine

and squalene.

Alkylglycerols are thought to be helpful in several ways. It

has been suggested that they fight cancer by killing tumor

cells indirectly. Proponents also claim that alkylglycerols

reduce the side effects of chemotherapy and radiation

treatment. Because of their supposed immune-boosting

effects, alkylglycerols are also claimed to help against

colds, flu, chronic infections, asthma, psoriasis, arthritis,

and AIDS.

Other compounds in shark liver oil, such as squalamine

and squalene, have also been promoted to have

anti-cancer effects. It is also being studied for use against

macular degeneration, an eye condition that results in loss

of vision. Squalene has been promoted as having

cell-protecting abilities, which may reduce the side effects

of chemotherapy.

30

SALMON OILA 100% natural oil, manufactured from salmons bred in the pure waters of southern Chile.Its production process allows it to certify

a controlled concentration of essential long-chain

Omega-3 fatty acids, Eicosapentaenoic acid (EPA)

and Docosahexaenoic acid (DHA).

18/12 F ISH OIL18/12 is a 100% natural edible oil, originating in the sea, highly refined and deodorized, enriched with long-chain Omega-3 fatty acids.Eicosapentaenoic acid (EPA) and Docosahexaenoic

acid (DHA), are essential for the proper nutrition of

human beings. The formulation of 18/12 oil allows

its application for direct consumption in the form

of liquid preparations or syrups, in gelatin

capsules, or in the formulation of functional foods.

Among its multiple benefits, it can be highlighted

that the consumption of 18/12 oil contributes to

maintaining and protecting the cardiovascular

system, reducing cholesterol and triglycerides in

the blood.

EPA

DHA

Total Omega-3

≥ 4.0

≥ 4.0

≥ 9.0

≥ 35

≥ 35

≥ 80

ITEM CONTENT[%]

CONTENT[mg/g]

31

OMEGA 3POWDERS

Omega-3 powders are manufactured using a breakthrough proprietary (U.S. patent pending) technology. Not only does this technology produce higher Omega-3 contents, it also gives oxidation stability. Omega-3 powder does not need to be refrigerated and is made from 100% fish oil or 100% plant oil.

Breakthrough TechnologyIt should be noted that advanced technology

increases the purity and oxidation stability of the

products. The health benefits and market demand

have been the driving force to research, develop

and manufacture Omega-3 powder and overcome

the obstacles over easier use, freshness,

purification and taste to provide the nutrition

industry with optimal applications.

Why Bestpharma Omega-3 Powder?

Patented form to create nature GRAS Omega-3 powder

Non-microencapsulated powder – double on DHA and EPA contents

High purity and concentrations of Omega-3 from 100% fish oil or 100% plant oil

Carbohydrate and protein free

High bio-availability

No refrigeration needed with longer shelf life

Almost tasteless and odorless

Easy to use for smaller capsules, tablets or food applications

Manufacture customized Omega-3 powder to meet specific formulations

L IST OF PRODUCTS

Omega-3 F30 PowderFish origin, Omega-3 30% (EPA + DHA)

Omega-3 P50 PowderPlant origin, Omega-3 50% (EPA + DHA + ALA)

Omega-3 PF40 PowderFish and plant origin, Omega-3 40%

Omega-3 A35 PowderAlgae origin, DHA ≥35%

32

OMEGA-3HCONCENTRATED FISH OILS:

Concentrated fish oil is a natural source of omega-3. It contains two times more omega-3 than other products containing fish oil.

Concentrated fish oil is the most common form

of food supplements. The types of fish that are

usually used for the production: sardines,

anchovies, herring, mackerel, salmon and

tuna.

Bestpharma is dedicated to supplying high

quality concentrated fish oils. During

production of Omega-3H oils, in addition to

traditional technologies in edible oil

industries, extra process and proprietary

purification technologies are adopted. This

enables our concentrates to set the most

stringent quality standards, which meet or

exceed all known limits set by GOED Voluntary

Monograph, Ph Eur Monograph and other

institutes.

GRADE UNIT EP USP GOED OMEGA-3H

Arsenic (As)

Lead (Pb)

Mercury (Hg)

Cadmium (Cd)

DDT (sum: p,p’-DDE + o,p’-DDT + p,p’-DDT + o,p’-DDD + p,p’-DDD)

HCB

Lindane

PCBs

Dioxins like PCBs

PCDD+PCDF (Dioxins+Furans)

Dioxins+Furans+Dioxins like PCBs

mg/kg

mg/kg

mg/kg

mg/kg

mg/kg

mg/kg

mg/kg

mg/kg

pg/kg

pg/kg

pg/kg

< 0.1

< 0.1

< 0.1

< 0.1

< 2

10

< 0.1

< 0.1

< 0.1

< 0.1

0.05

0.05

0.5

1

< 0.1

< 0.1

< 0.1

< 0.1

< 0.09

< 3

< 2

NA

< 0.1

< 0.05

< 0.005

< 0.01

< 0.01

< 0.005

< 0.005

< 0.01

< 3

< 1

< 4

Omega-3H ogranic pollutants content comparison to EP, USP and GOED standards

33

Omega-3H oils are guaranteed to have the lowest possible oxidation levels. This was achieved by

focusing on protecting the oil from exposure to air and unnecesary heating with high temperatures during

the whole process. This was carried out thanks to an improved Short-Path Distillation (SPD) technology

which allows to conduct the distillation process in airtight, vacuum conditions in nitrogen environment.

This state-of-the-art process lowers the evaporation temperatures of processed oil. The measures taken

in the production of Omega-3H concentrates give the purest Omega 3 oil concentrates twith the lowest

possible oxidation levels.

GRADE UNIT EP USP GOED OMEGA-3H

Acid value

Peroxide value

Anisidine value

TOTOX

mgKo/g

meg/kg

< 2.0

< 10

< 20

NA

< 2.0

< 10

< 15

NA

< 3.0

< 5

< 20

< 26

< 1.0 (0.5, ultra)

< 3 (2. ultra)

< 15 (5, ultra)

< 20 (9, ultra)

Omega-3H oxidation levels comparison to EP, USP and GOED standards

34

TRIG

LYC

ERID

E FO

RM

CODE NAME EPA [mg/g] DHA [mg/g]

035024

035025

035030

035031

035032

035033

035017

035018

035019

035020

035021

035022

035023

035000

035035

035036

035037

035038

035039

035034

035026

035027

035028

035029

035010

035011

035012

035013

035014

035015

035016

035008

035009

035001

035002

035003

035004

035005

035006

035007

035008

Omega-3H 3322TG

Omega-3H 3020TG

Omega-3H 2050TG

Omega-3H 1050TG

Omega-3H 2040TG

Omega-3H 1040TG

Omega-3H 6015TG

Omega-3H 5525TG

Omega-3H 5025TG

Omega-3H 5020TG

Omega-3H 4030TG

Omega-3H 4020TG

Omega-3H 3624TG

Omega-3H 6020TG

Omega-3H EPA700TG Ultra

Omega-3H DHA700TG Ultra

Omega-3H 7505TG Ultra




Omega-3H 2050EE

Omega-3H 1050EE

Omega-3H 2040EE

Omega-3H 1040EE

Omega-3H 5525EE

Omega-3H 5025EE

Omega-3H 5020EE

Omega-3H 4030EE

Omega-3H 4020EE

Omega-3H 3624EE

Omega-3H 3322EE

Omega-3H 1070EE

Omega-3H 6015EE

Omega-3H 1812EE

Omega-3H 3020EE

Omega-3H EPA700EE Ultra

Omega-3H DHA700EE Ultra

Omega-3H 7505EE Ultra




330

300

200

100

200

100

600

550

500

500

400

400

360

600

700

0

750

700

50

100

200

100

200

100

550

500

500

400

400

360

330

100

600

180

300

700

0

750

700

50

100

220

200

500

500

400

400

150

250

250

200

300

200

240

200

0

700

50

100

750

700

500

500

400

400

250

250

200

300

200

240

220

700

150

120

200

0

700

50

100

750

700

ETH

YL E

STH

ER F

OR

M1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

37

38

39

40

4135

Bestpharma

BestCoatBestCoat

36

BESTCOAT

Bestpharma offers a broad range of tablet coating systems, many of which can

be designed according to the Customer's needs.

We offer three systems of BestCoat™ mixtures ready for preparation of coating

suspensions. They are available in a wide range of colors based on the Pantone

color palette.

We also provide free samples in order to verify the color. We start a

batch production only after approval of the presented sample by the

Customer.

Our advantage is our flexible approach to the Customer. We cooperate

with companies which can set-up the coating process on every coating

machine and train the staff in a particular process.

We encourage you to look through the details of our offer.

* For pharmaceutical products, it is necessary to inform BESTPHARMA about such intended use.

The coatings are based on both syntheticand natural pigments

Each coating system is tailored to the Customer's needs.

The color of coating is tailored to the Customer's needs.(In the case of natural pigments, the number of available colors is limited)

Available for both the food, and pharmaceutical industry*.

01

02

03

04Best

Coat

™sy

stem

37

First, the BESTCOAT™ coating is applied to the tablets, with a chosen color, in order to obtain a depth effect.

The process of basic coating application is usually continued until the increase in tablets mass amounts to 3 % of non-coated tablets.

S IMPLICITY

Application of double-system coatings produces a magnificent visual effect and, at the same time, does not significantly increase

the amount of work or production costs.

The recommendations regarding proper use of the BESTCOAT™ PEARL coating process are similar, as in the case of the basic

system. The recommended concentration of BESTCOAT™ PEARL solution expressed as dry content is from 12% to 20%.

Coating application is very simple

Basic coating system, in which all the ingredients are passed as fit for the food industry. Available in various colors, based on soluble pigments or color lakes.

Hypromellose (HPMC)

Polydextrose

Titanium dioxide

Polyethylene glycol

Talc

E 464

E 1200

E 171

E 1521

E 553b

BESTCOAT ™

If polyethylene glycol is not acceptable in the composition, we suggest this coating in which PEG was substituted with medium -chain triglycerides (MCT).

BESTCOAT ™

MCT

Hypromellose (HPMC)

Polydextrose

Titanium dioxide

Polyethylene glycol

Talc

Medium chain triglycerides

E 464

E 1200

E 171

E 1521

E 553b

—

A system with additional plasticizer - triacetin, which increases the coating's plasticity and its adhesion to the core.

BESTCOAT ™

TRI

Hypromellose (HPMC)

Titanium dioxide

Lactose monohydrate

Polyethylene glycol

Triacetin

E 464

E 171

—

E 1521

E 1518

01

Tablets are then dried up for 10 minutes.

02

Next, application of the BESTCOAT™ PEARL coating proceeds. The process of spraying is continued until the increase in mass reaches from 0.5 % to 1.5 % of non-coated tablet cores.

Both systems are compatible, and it is not necessary to wash hoses and nozzles before application of the BESTCOAT™ PEARL system.

03

38

Hypromellose (HPMC)

Potassium Aluminum Silicate

Titanium dioxide

Polyethylene glycol

E 464

E 555

E 171

E 1521

A system which gives the tablets a pearlescent shine. A double-system solution comprising of the BESTCOAT™ basic system and the BESTCOAT™ PEARL system.

The procedure of coating preparation is similar. The coating system comprises of a dry mixture of ingredients which are ready for direct preparation of the coating suspension. The system does not require a homogenizer. A container with a low speed mixer is enough.

BESTCOAT™PEARL -

Hypromellose (HPMC)

Polydextrose or Sucrose

Titanium dioxide

Sorbitol

Talc

Medium chain triglycerides or Triacetin

E 464

E 1200

E 171

E 420

E 553b

E 1518

BESTCOAT FLEXIBLE MEMBRANE™ is an innovation on the coating systems market and it performs very well in dealing with the so called „difficult cores”.

The latest product by Bestpharma. Owing to the applied composition of ingredients, the system ensures that the obtained coating is elastic. It is important in the case of tablets – cores, which tend to expand. The version of the system with sucrose is the cheapest coating in our offer. It is available both in white color, and in any other color offered by Bestpharma. It is perfectly suitable as a substitute of former coatings used in sucrose coated tablets and, at the same time, it allows coating mass increase by 3%. The coating has a sweet taste and so it imitates former sucrose coated tablets. In case you want to increase sweetness, we also offer a version in which a combination of sucrose and a sweetener – sucralose is used. In applications in which the content of sugar is undesirable, we apply polydextrose . Depending on our customers’ needs the system can utilize two variants of plasticizers. We can prepare an elastic coating using triacetin or medium-chain triglycerides as plasticizers.

BESTCOATFLEXIBLE MEMBRANE™

39

RECOMMENDATIONS DESCRIPTION

Container, tank for solution preparation

Mixer: size and speed

Recommended concentrations of the suspension expressed as dry content

Water temperature

The procedure of dissolving (suspending) the dry coating mixture

Filtering of ready solution

The container size should be adjusted to the amount of solution. The volume taken up by the solution in the tank should be from 60% to 75% of the whole tank. The tank should be slender, i.e. higher than broader. It should be remembered that an another container is required for pouring the solution through a sieve before coating.

The type of mixer is very important, since using improper mixer can produce foam in the suspension, which is undesirable. The best way is to use a paddle mixer. The mixer should be immersed in the solution 3 - 5 cm from the bottom of the container or tank. Mixer speed should be adjusted, so as to form a swirl. The mixer diame-ter should be in the range of 1/4-1/3 of the container diameter.

The solution concentration should be adjusted to the process and to the owned equipment. The recommended solution concentra-tion expressed as dry content is from 12% to 20%.

To prepare the coating suspension, you should use purified water with the room temperature of 30°C.

The dry coating mixture should be poured into the water container directly into the swirl, with constant mixing. Too rapid pouring should be avoided, so as not to produce big agglomerates of the mixture. Also, you should not let the mixture float on the surface. After adding the calculated amount of the mixture, you should decrease the mixer speed and continue mixing for 45 minutes.

Ready solution should be poured through a sieve with 0.4-mm holes in order to get rid of lumps, which prevents nozzles from blocking, and assures smooth surface of tablets. The filtered solution should be constantly mixed at low speed, during the whole coating process.

COATING PREPARATION

SUSPENSION PREPARATION

40

RECOMMENDATIONS DESCRIPTION

Preparation of tablet cores for the process

Coating process parameters

Mass increase

Termination of coating process

Tablets stabilizing

Bed temperature should be adjusted to the composition of tablet cores. If there are no restrictions associated with the stability of cores, it is recommended to warm up the bed up to 35°C. The warming up of the bed should be conducted with the drum rotation being turned on from time to time.

The spraying air pressure depends on the nozzles applied and should be 2.2 bar - 3.2 bar. Before starting the process you should check the correctness of spraying, and particularly the shape of the sprayed suspension. It is best to do it outside the drum, by spraying the coating on a chosen flat surface, e.g. a steel tray. After starting the process it is necessary to apply vacuum in the drum, which protects from excessive dusting. The temperature of inlet air pressure and its flow rate should be adjusted to the owned equip-ment, the size of bed, number of nozzles, and the rotation rate of the drum. The recommended inlet air temperature should be 45-55°C. It is recommended to apply slower rotation rate of the drum and slower spraying at the beginning of the process, in order to strengthen the cores. Next process can be sped up to ensure its efficiency, while maintaining its quality parameters.

The increase of coating mass should be adjusted to the require-ments of the process, the quality of cores, and marketing demands. Most of the times, it is recommended to continue the process until a 3% to 4% increase of tablet mass is reached.

Before unloading, the bed should be dried up at 20 - 25°C, at the minimum rotational speed of the drum. The process should be continued for 20 minutes.

After the coating process is complete and the coated tablets are unloaded, they should be left for approximately 2 hours in open container to reach equilibrium with the environment.

COATING PROCESS

41

Y 001 Y 006 Y 011 R 001

Y 001 Y 007 Y 012 R 002

Y 002 Y 008 Y 013 R 003

Y 003 Y 009 Y 014 R 004

Y 004 Y 010 R 005

BESTCOAT COLORS

YELLOW (Y) RED (R)

Below you will find the most popular colors, often chosen by our customers. As mentioned before, we are able to prepare any color based on the Pantone® color pallete.

* Please note that the color propositions and symbols do not correspond to a specific BestCoat mixture. The symbols only indicate the chosen color

42

43

R 006 001 G 001B 005

R 007 B 002 B 006 G 002

R 008 B 003 B 007 G 003

R 009 B 004 B 008 G 004

B 009 G 005

BLUE (B)

CONTACT DETAILS

+48 22 247 28 96

www.bestpharma.pl

[email protected]

03-475 Warsaw

2 Borowskiego street (floor 5)

44

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+48 22 247 28 [email protected]

2 Borowskiego street03-475 Warszawa

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