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6/14/20
1
BobbySaenz,O.D.,M.S.,F.A.A.O.
MitchIbach,O.D.,F.A.A.O
Disclosureslide
Glaucoma• Agroupofdiseasesthatdamagetheeye’sopticnerveand
canresultinvisionlossandblindness
• 2ndleadingcauseofblindnessinUSA– PATIENTSDON’TEVENKNOWTHEYHAVEIT!!
• 3millionAmericanshaveglc,
butonlyhalfknowtheyhaveit
• 2ndleadingcauseofblindness– PATIENTSDON’TEVENKNOWTHEYHAVEIT!!
• 3millionAmericanshaveglc,
butonlyhalfknowtheyhaveit
Arepatientsgoodattakingeyedrops?
Howgoodareyourpatientsattakingdrops?
What’stheproblem?
• Education?
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What’shappeninginglaucoma?
• Over-production?• Under-drainage?
Whyareourpatientsnottakingtheirdrops?
What’stheproblem?• Education
• Numberofgtts?
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Conclusions:...lessfrequentdosingregimensresultedinbettercomplianceacrossavarietyoftherapeuticclasses. Persistenceandadherencebestwithprostaglandins
What’stheproblem?• Education?• Numberofgtts?
• Cost?
HwangD,LiuCJ,PuC,ChouY,ChouP.PersistenceofTopicalGlaucomaMedication:ANationwidePopulation-BasedCohortStudyinTaiwan.JAMAOphthalmol.2014;132(12):1446–1452.doi:10.1001/jamaophthalmol.2014.3333
75.8%!!!!!!!!!!Includingthecost!
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Patientsreportedfarhighermedicationusethantheiractualbehavior.
NearlyHALFptsuseddropslessthan75%ofthetime.
Theabilityofthephysiciantoidentifywhichpersonsarepoorlyadherent….
ISPOOR
Andforthosewhoactuallydoputineyedrops?
Infact,upto80%ofpatientscontaminatetheirdropsbytouchingtheirface,upto61%donotinstillexactlyonedropand,mostcritically,upto37%misstheeyewiththedrop.
Sideeffects?
Howcanwehelpourpatients?
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DrugDelivery
• Rings(BimatoprostRings)
• Punctalplugs(travoprostpunctumplug)
• Contactlenses(latoprostelutingcontactlens)• Intracameralinjections
iDose Implant
iDose resides in the anterior chamber angle, anchored into the scleral tissue just behind the trabecular meshwork
FirstiDoseimplantintheU.S.performedbyDr.JohnBerdahlM.D.inSiouxFallsSD,
VanceThompsonVisiononMarch29,2016
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CataractSurgery
RemoveCataract
CorrectRefractive
ErrorMIGS Happier
Patients
AreasofAqueousOutflow
Outflow Pathway Disease State
Trabecular Meshwork Mild-to-Moderate
Suprachoroidal Space Progressive
Subconjunctival Space Refractory
1
23
Benefit-to-risk ratio is the ultimate criterion in
determining MIGS treatment algorithm
MIGS devices can be used to restore outflow through:
1
2
3
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Schlemm’sCanal/TM 1. Bypass– iStentinject
2. Dilate-Omni3. Cut/Ablate–KDB
ISTENTINJECTTRABECULARMICRO-BYPASSSTENTSYSTEM
v Twotrabecularbypassstents;abinternoimplantation
v Multiplestentplacementdesignedtoincreaseaccesstomorecollectorchannels
v Multipleoutletlaterallumensprovideexitrouteforaqueousfromanteriorchamber
iStentinject
IOPREDUCTION
1.6 1.5
0.4
0.8
No.Meds
47%
reduction
75%
reduction
MEDICATIONBURDEN
0.4
0.8
Preop(n=380)
M23(n=357)
M23(n=109)
Preop(n=118)
50%FewerMeds
withiStentinject+PhacoatMonth23
iStentinject+Phaco(n=357)
Phaco
Alone(n=109)
iStentinject+Phaco PhacoAlone
84%ofiStentinjectsubjectsweremedication-freeat23months
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Post-OpAdverseEvents
iStentinject+Phaco
N=386
n(%)
PhacoOnly
N=119
n(%)
Stentobstruction 24(6.2%) NA
Intraocularinflammation 22(5.7%) 5(4.2%)
BCVAloss≥2linesat/afterM3 10(2.6%) 5(4.2%)
IOPincrease≥10mmHgat/afterM1 8(2.1%) 1(0.8%)
Cornealabrasion 8(2.1%) 4(3.4%)
Goniosynechiae 7(1.8%) 0(0.0%)
IOPincreaserequiringoralmedsorSSI
at/afterM11(0.3%) 3(2.5%)
SecondaryglaucomasurgerySLT
Trabeculectomy/Expressshunt
2(0.5%)
4(1.0%)
3(2.5%)
1(0.8%)
SAFETYOUTCOMESOcularAdverseEventsofInterestThrough24Months
Noreportsof:
• Myopicshift• FlatAC• Choroidalhemorrhage/effusion• Cyclodialysis• Hypotony≥1month• Hypotonymaculopathy• Stentdislocation• Significanthyphema• Cornealdecompensation
Don’twantpatientstomissoutonthis
iStentinjectPost-OpImages
CourtesyofDr.MarcToteberg2-yearpost-op
CourtesyofDr.GeorgeReiss
HENGERER(3YEAR)Long-termIOPReductionat3Years1
1. HengererFH.PersonalExperiencewithSecond-GenerationTrabecularMicro-BypassStentsinCombinationwithCataractSurgeryinPatientswithGlaucoma:3-YearFollow-up.ASCRS2018Presentation.
37%
37%reductionfrom
preopIOP
100%ofpatientswithIOP≤18mmHg
• IntraocularPressureOverTime
AblateorViscodilateKahookDualBlade
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• Successrate68.8%• 1week>10mmHg:10%
Hydrusmicrostent
• MildtoModPOAG
• BypassanddilatesSC
OmniAreasofAqueousOutflow
Outflow Pathway Disease State
Trabecular Meshwork Mild-to-Moderate
Suprachoroidal Space Progressive
Subconjunctival Space Refractory
1
23
Benefit-to-risk ratio is the ultimate criterion in
determining MIGS treatment algorithm
MIGS devices can be used to restore outflow through:
1
2
3
AreasofAqueousOutflow
Outflow Pathway Disease State
Trabecular Meshwork Mild-to-Moderate
Suprachoroidal Space Progressive
Subconjunctival Space Refractory
1
23
Benefit-to-risk ratio is the ultimate criterion in
determining MIGS treatment algorithm
MIGS devices can be used to restore outflow through:
123
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Xengelshunt XenGelStent
BlebitisCase1:60yoHM–cataractevaland
OHTN• +3.00sph20/30OU• IOPOD28OS27
iStentinject
• Mildtomoderateopenangleglaucoma
• Needdocumentation(HVFandOCT)toprovetotheinsurancethatthepatienthasglaucoma
• Needstobeondroppriortosurgery
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Case1:s/pCEOUandiStentinject
• IOPOD17OS19• IOPreduction39.2%OD• IOPreduction29.7%OS
Doweneedtoaddanotherdrop?
Case2:72yoWMcataracteval• OMDsaidIOPundercontrolandhasbabycataracts• OD31mmHgOS31mmHg
– LatanoprostqhsOU,BrimonidineTIDOU,CosoptBIDOU• Gonioopen• Averagepachs• (+)FamHx• BCVA20/25OU,BAT20/50OU
s/pLensARtoricIOLOUandiStentinjectOU
• 1dayOSIOP:32mmHg
• 3dayOSIOP:15mmHg
• 1weekOSIOP:16mmHg
• 6weekOSIOP:10mmHg
Nowwhatdowedo?
RememberptonCosopt,Brimonidine,and
Latanoprost
MIGStips• BeawareofMIGS• Determineifpatienthasglaucomabeforesendingforcataractevalifpossible
• SendtosurgerygroupwhodoesMIGS• Don’tchangedropstilabout6weekspostop
– BeawareofIOPelevationat1dayduetovisco– BeawareofIOPelevationafterduetosteroidresponse
RoleofODsisonlygoingtoget
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