Upload
others
View
0
Download
0
Embed Size (px)
Citation preview
Curriculum Vitae
Name: Sean Patrick Didion, PhD, FAHA
Campus Address: The University of Mississippi Medical Center Departments of Pharmacology and Neurology
Arthur C. Guyton Laboratory Research Building
2500 North State Street
Jackson, Mississippi 39216
Phone: (601)-984-1710 Email: [email protected]
Marital Status: Married: Lisa Ann Didion, MD, FAAP
Associate Professor & Chief Medical Officer
Director, Office of Patient Satisfaction Batson Children’s Hospital
Department of Pediatrics
University of Mississippi Medical Center
Jackson, Mississippi 39216
Children: Riley Ann, 13 years
Andrew James, 11 years
Colin Patrick, 8 years
Mairead Emma, 7 years
EDUCATION:
Year Degree Institution Major 1991 B.S. Drake University Biology
1994 M.A. Drake University Biology
1998 Ph.D. University of Nebraska Molecular and Cellular Physiology
Curriculum Vitae
Page 2
Sean P. Didion, PhD, FAHA
ACADEMIC POSITIONS:
1998-2002 Post-doctoral Fellow, Department of Internal Medicine, Division of
Cardiovascular Medicine, The University of Iowa
2002-2003 Assistant Research Scientist, Department of Internal Medicine, Division
of Cardiovascular Medicine, The University of Iowa
2003-2005 Associate Research Scientist, Department of Internal Medicine, Division
of Cardiovascular Medicine, The University of Iowa
2006-2008 Research Scientist, Department of Internal Medicine, Division of Cardiovascular Medicine, The University of Iowa
2009-2011 Assistant Professor, Department of Neurology and The Vascular Biology
Center, Medical College of Georgia
2011- Associate Professor, Departments of Pharmacology and Neurology, The
University of Mississippi Medical Center
2012-2014 Associate Director, Department of Pharmacology Graduate Program,
The University of Mississippi Medical Center
2012- Director, MD/PhD Program, The University of Mississippi Medical Center
2015- Associate Professor with Tenure, Departments of Pharmacology and
Neurology, The University of Mississippi Medical Center
Brief Biography: Dr. Sean P. Didion, Ph.D. is an Associate Professor in the
Departments of Pharmacology and Neurology at the University of Mississippi Medical
Center (UMMC) in Jackson, MS. He received his B.S. and M.A. degrees in Biological
Sciences from Drake University and his Ph.D. degree in Physiology under the
mentorship of Dr. William G. Mayhan, PhD in the department of Cellular and
Curriculum Vitae
Page 3
Sean P. Didion, PhD, FAHA
Molecular Physiology (chaired by Dr. Irving H. Zucker, PhD) from The University of
Nebraska Medical Center. His postdoctoral training was conducted at the University of
Iowa Carver College of Medicine under the mentorship of Dr. Frank M. Faraci, PhD. Dr. Didion's current research is focused on understanding mechanisms by oxidative
stress and inflammatory molecules play in the impairment of vascular function in
development of obesity and hypertension. Dr. Didion has maintained an uninterrupted
track record of funding as a Principal Investigator, which has totaled nearly $9 million
(approx. $3 million as Principal Investigator) to date. Dr. Didion's work is currently funded by 2 R01's from the National Institutes of Health. In recognition of his research,
he received the UMMC Gold Medal for Excellence in Research in 2012. He is an
active member of the APS, having served on the Membership Committee and Perkins
Memorial Award Committees. Dr. Didion has served on the Editorial Boards of the leading cardiovascular journals in his field, including, Atherosclerosis, Thrombosis,
and Vascular Biology, Circulation Research, and Hypertension. Dr. Didion is a 2014
graduate of the UMMC Leadership Development Program and is the director of the
UMMC MD/PhD Program. Dr. Didion's wife, Dr. Lisa A. Didion, MD, is an Associate Professor in the Departmen
of Pediatrics and Associate Chief Medical Officer of Children's of Mississippi. They
have 4 children and currently live in Madison, MS.
Teaching and Education: Evaluation of Dr. Didion's course directorship and teaching in Medical, Dental, and Graduate Pharmacology courses has been extremely positive.
Dr. Didion has also been recognized for his efforts to raise-the-bar by recruiting
nationally recognized speakers to the Pharmacology Seminar Series and he was
instrumental in ensuring that the departmental seminar series meet on a weekly basis.
In addition, Dr. Didion established a weekly Journal Club series to the Department of Pharmacology thereby bringing faculty, students and trainees together to discuss the
most recent advances, topics and papers in the field of Pharmacology. Dr. Didion
worked to ensure that faculty as part of their education evaluated students and
trainees. Dr. Didion has also worked to formalize many of the educational components
Curriculum Vitae
Page 4
Sean P. Didion, PhD, FAHA
related to the MD-PhD program, all of which has been well received by students and
faculty alike.
Administrative Expertise and Interests: Dr. Didion fulfills a number of service-
related roles both at the departmental and institutional levels, but also at the national
and international level with his involvement in the National Association of MD-PhD
Directors and the AAMC GREAT Group. Dr. Didion is working toward developing
innovative methods for the education and training of physician-scientists and looks to bring his ideas to the national arena, as training and development of future physician-
scientists is one of Dr. Didion’s passions.
Services and Procedures: Dr. Didion is currently the Director of Histological Services for the Department of Pharmacology. Services provided by Dr. Didion include, tissue
processing, sectioning of paraffin embedded tissues as well as fixation of fresh frozen
tissues. Dr. Didion provides routine histological staining of paraffin-fixed tissues,
including H&E, Masson’s Tri-chrome, PAS. Services also provided by Dr. Didion
included specialized immunohistochemistry techniques. Dr. Didion also provides image and data analysis and quantification. This is a major service that Dr. Didion
provides to the Department of Pharmacology and it is estimated that as of January
2016 to date Dr. Didion has processed well over 5,000+ tissue samples and more
than 12,000+ individual slides for departmental faculty.
AWARDS & HONORS:
1994-1997 American Heart Association Pre-Doctoral Fellowship
1996 Procter & Gamble Professional Opportunity Award, Cardiovascular Section, American Physiological Society
1996 1st Place Basic Science Oral Presentation, Student Research Forum,
University of Nebraska Medical Center
1997-1998 Blanche Widaman Fellowship & Regents Tuition Fellowship, University of Nebraska Medical Center
Curriculum Vitae
Page 5
Sean P. Didion, PhD, FAHA
1998 Alice Cummings Prize in Physiology (Top Physiology Student Award),
University of Nebraska Medical Center
1998-1999 Institutional Research Fellowship, The University of Iowa, National
Institutes of Health (HL-07121-23)
2000-2001 Individual National Research Service Award, National Institutes of Health (HL-
10237-01)
2002-2005 Scientist Development Award, American Heart Association, National Affiliate
2002 Young Investigator Award, International Society of Hypertension
2002 Merck New Investigator Award, High Blood Pressure Council, American Heart
Association
2006 Young Scholar Award, American Society of Hypertension
2009 Recognized as a Superior Editorial Consultant for Circulation Research
2012 Fellow of the American Heart Association, High Blood Pressure Council
2012 Gold Medal in Research Excellence Award, University of Mississippi
Medical Center
2017 5 Year Service Award, National Association of MD-PhD Programs
PROFESSIONAL SOCIETIES:
1993- American Association for the Advancement of Science
1996- American Physiological Society
2001- Member, Stroke Council, American Heart Association
Curriculum Vitae
Page 6
Sean P. Didion, PhD, FAHA
2001- Member, Council on Basic Cardiovascular Sciences, American Heart
Association
2002- Member, High Blood Pressure Council, American Heart Association
2004- Member, North American Vascular Biology Organization
2006-2008 American Society of Hypertension
2012- Member, American Society for Pharmacology and Experimental
Therapeutics
2013- Member, Society for Free Radical Biology and Medicine
2015- Life Member, Mississippi Academy of Sciences
2015- Member, American Association of University Professors
PROFESSIONAL SERVICE:
2006-2010 National Peer Review, Vascular Biology and Blood Pressure Regulation Committee, American Heart Association
2009-2011 Medical College of Georgia, Vascular Biology Center Post-Doctoral
Fellow Review Committee Member
2010-2014 Member, American Physiological Society, Membership Committee Member
2013- Member, National American Heart Association Vascular Biology and
Blood Pressure Regulation Study Section
2014- Member, American Physiological Society, Perkins Memorial Fund
Committee
2015 Ad Hoc Member, Diabetes United Kingdom, Grant Review Committee
Curriculum Vitae
Page 7
Sean P. Didion, PhD, FAHA
2015 Member, Cardiovascular Health One, National Peer Reviewed Medical
Research Program, Department of Defense Congressionally Directed
Medical Research Programs
2016- Member, Vascular Malformations, National Peer Reviewed Medical
Research Program, Department of Defense Congressionally Directed
Medical Research Programs
EDITORIAL BOARDS:
2006-2013 Circulation Research
2007- Hypertension
2010- Frontiers in Physiology - Oxidant Physiology
2010-2012 Atherosclerosis, Thrombosis, and Vascular Biology
2012-2015 American Journal of Cardiovascular Disease
2013- Frontiers in Physiology - Cardiac Electrophysiology
2016- Journal of Hypertension
AD HOC REVIEWER FOR JOURNALS:
American Journal of Physiology – Heart and Circulatory Physiology
American Journal of Physiology – Regulatory and Integrative Physiology
Antioxidants and Redox Signaling
Atherosclerosis, Thrombosis and Vascular Biology (ATVB)
Basic & Clinical Pharmacology & Toxicology
Biochimica et Biophysica Acta – Molecular Basis of Disease
Biological Research for Nursing
Brain Research
Curriculum Vitae
Page 8
Sean P. Didion, PhD, FAHA
British Journal of Pharmacology
Circulation
Circulation Research
Coronary Artery Disease
Current Medicinal Chemistry
Diabetes
Diabetes Care
Diabetic Medicine
FASEB Journal
FEBS Letters
Free Radical Biology and Medicine
Frontiers: Cardiovascular Medicine
Hypertension
Journal of the American Heart Association
Journal of Applied Physiology
Journal of Hypertension
Journal of Hypertension Research
Journal of Molecular Histology
Life Sciences
Microcirculation
Microvascular Research
Molecular Neurobiology
Pharmacological Research
Public Library of Science (PLoS) One
Curriculum Vitae
Page 9
Sean P. Didion, PhD, FAHA
Stroke
Translational Research
Vascular Pharmacology
INVITED LECTURES:
2004 Department of Pathology, “Vascular Protection: Role of Superoxide Dismutase and PPAR-gamma”, Weill Medical College, Cornell
University, New York, New York
2004 Department of Cellular and Molecular Physiology, “Mechanisms of Oxidative Stress and Protection in the Vasculature”, University of North
Carolina, Chapel Hill, North Carolina
2004 Department of Physiology, “Oxidative Stress and Vascular Function”,
University of Mississippi Medical Center, Jackson, Mississippi
2004 Department of Physiology, “Role of CuZn-Superoxide Dismutase in
Vascular Protection”, West Virginia University, Morgantown, West
Virginia
2006 Winter Conference on Brain Research, “Super Size Me: Vascular
Responses in the Cerebral Circulation in Obesity and Type II Diabetes”,
Steamboat Springs, Colorado
2006 American Society of Hypertension, Young Scholar Award Lecture, “Vascular Dysfunction in Obesity and Type II Diabetes: New
Perspectives from Genetic Models”, New York, New York
Curriculum Vitae
Page 10
Sean P. Didion, PhD, FAHA
2006 Neuroscience Program, “Role of Superoxide Dismutases in Limiting
Cerebral Vascular Dysfunction”, Michigan State University, East
Lansing, Michigan
2006 Department of Neurology Grand Rounds, “Role of Superoxide
Dismutases in Limiting Cerebral Vascular Dysfunction”, University of
Iowa Hospital and Clinics, Iowa City, Iowa
2007 23rd International Symposium on Cerebral Blood Flow and Metabolism,
“The Role of Oxidative Stress in the Cerebral Circulation”, Osaka, Japan
2007 Center for Cardiovascular Sciences, “Oxidative and Inflammatory Mechanisms Associated with Cerebral Vascular Dysfunction”, Albany
Medical College, Albany, New York
2007 Iowa and Nebraska Physiology Societies Combined Meeting, “Genetic
Deficiency of Interleukin-6 Protects Against Angiotensin II Induced Endothelial Dysfunction and Hypertrophy”, Nebraska City, Nebraska
2007 Vascular Biology Center, “Oxidative and Inflammatory Mechanisms
Associated with Cerebral Vascular Dysfunction”, Medical College of
Georgia, Augusta, Georgia
2008 Department of Cellular and Molecular Physiology, “Oxidative Stress,
Inflammation, and Angiotensin Too”, University of Nebraska Medical
Center, Omaha, NE
2010 Vascular Biology Center, “Stress, Strain, and Angiotensin II: Let’s
Rho’ll”, Medical College of Georgia, Augusta, GA
2010 Department of Pharmacology, “Inflammatory Mechanisms of Aging and Hypertension”, University of Mississippi Medical Center, Jackson, MS
Curriculum Vitae
Page 11
Sean P. Didion, PhD, FAHA
2010 Department of Cellular and Molecular Physiology, “Inflammatory
Mechanisms of Hypertension”, Loyola University Stritch School of Medicine, Maywood, IL
2010 Department of Medicine, Division of Cardiovascular Medicine,
“Inflammatory Mechanisms of Endothelial Dysfunction: Insights from IL-6
and IL-10”, University of Cincinnati, Cincinnati, OH
2011 Department of Health and Human Physiology, “Vascular Dysfunction in
Aging and Hypertension: A Pro-Inflammatory Role for Interleukin-6”, The
University of Iowa, Iowa City, IA
2013 Department of Physiology, “Vascular Phenotypes and Whole Genome
Profiles in Obesity: The Mirrored Maze of Mouse Models”, The
University of Mississippi Medical Center, Jackson, MS
2014 Department of Pharmacology, “Hypertension, Endothelial Dysfunction
and Angiotensin Too”, The University of Mississippi Medical Center,
Jackson, MS
2014 Department of Physiology, “Inflammation, Endothelial Dysfunction and Angiotensin II”, Tulane University, New Orleans, LA
2016 Center for Cardiovascular and Renal Research, “Novel Genetic Mouse
Model of Hypertension”, The University of Mississippi Medical Center,
Jackson, MS
2016 AAMC GREAT and GRAND Group Meeting, “Shaping the Future of the
Physician-Scientist Workforce: Enhancing Pre-doctoral Fellowship
Success Rates through a Proactive and Team-based Approach, Chicago, IL
Curriculum Vitae
Page 12
Sean P. Didion, PhD, FAHA
TEACHING ACTIVITIES: (Classroom, Laboratory and Journal Club)
1991-1992 Laboratory Instructor, Biology I for Majors, Drake University, Des Moines, Iowa
1992-1993 Laboratory Instructor, Biology II for Majors, Drake University, Des Moines, Iowa
1991-1992 Laboratory Instructor, Comparative Anatomy, Drake University, Des Moines,
Iowa
1993-1998 Cardiovascular Journal Club, Department of Physiology, University of Nebraska
Medical Center, Omaha, Nebraska
1993-1994 Neuroscience Journal Club, Department of Pharmacology, University of
Nebraska Medical Center, Omaha, Nebraska
1995-1996 Medical Physiology - Radiation Technology Students, Endocrinology and
Reproductive Physiology, University of Nebraska Medical Center
1998-2008 Cardiovascular Journal Club, Department of Internal Medicine, The University
of Iowa, Iowa City, Iowa
2005-2008 Free Radical Journal Club, Department of Free Radical Biology, The
University of Iowa, Iowa City, IA
2009-2011 VBI 8020: Frontiers in Vascular Biology (2 contact hours), The Medical College
of Georgia, Augusta, GA
2010-2011 VBI 9020: Vascular Biology Journal Club (28 contact hrs), Course Director, The
Medical College of Georgia, Augusta, GA
2010-2011 VBI 9020: Vascular Biology Journal Club (1 Credit Hr/Semester), Course
Director, The Medical College of Georgia, Augusta, GA
Curriculum Vitae
Page 13
Sean P. Didion, PhD, FAHA
2012-2014 PHARM 701: Pharmacology Seminar (28 contact hrs), Course Director, The
University of Mississippi Medical Center, Jackson, MS
2012-2014 PHARM 702: Pharmacology Journal Club (28 contact hrs), Course Director,
The University of Mississippi Medical Center, Jackson, MS
2012-2014 ID 727: Current Issues in Biomedical Research (2 contact hrs), The University
of Mississippi Medical Center, Jackson, MS
2012- PHARM 620: Introduction to Pharmacology and Therapeutics (6 contact hrs)
2012- PHARM 626: Dental Pharmacology (3 contact hrs), The University of
Mississippi Medical Center, Jackson, MS
2012- PHARM 723: Mechanisms of Drug Action (4 contact hrs), The University of
Mississippi Medical Center, Jackson, MS
2016- PHARM 724: Experimental Design & Methods to Study Cell Signaling (3
contact hrs), The University of Mississippi Medical Center, Jackson, MS
2016- MD-PhD Journal Club (12 contact hrs), The University of Mississippi Medical
Center, Jackson, MS
DEPARTMENTAL SERVICE:
2009-2011 Medical College of Georgia, Vascular Biology Center Post-Doctoral
Fellow Review Committee Member
2012-2014 Director, Seminar Program, Department of Pharmacology, The University of
Mississippi Medical Center, Jackson, MS
2012-2014 Director, Journal Club, Department of Pharmacology, The University of
Mississippi Medical Center, Jackson, MS
Curriculum Vitae
Page 14
Sean P. Didion, PhD, FAHA
2012-2014 Associate Director, Pharmacology Graduate Program, Department of
Pharmacology, The University of Mississippi Medical Center, Jackson, MS
2016 Member, Departmental Review Committee, Department of Pharmacology, The
University of Mississippi Medical Center, Jackson, MS
2012-2015 Member, Graduate Program Committee, Department of Pharmacology, The
University of Mississippi Medical Center, Jackson, MS
2015- Member, Faculty Recruitment Committee, Department of Pharmacology, The
University of Mississippi Medical Center, Jackson, MS
2016- Member, Faculty Strategic Planning Committee, Department of Pharmacology,
The University of Mississippi Medical Center, Jackson, MS
2017- Member, Professional Education Committee, Department of Pharmacology,
The University of Mississippi Medical Center, Jackson, MS
INSTITUTIONAL SERVICE:
2009 Member, Medical Library Director Search Committee, The Medical College of
Georgia
2012- Chair, MD/PhD Program Advisory Board, The University of Mississippi
Medical Center, Jackson, MS
2012- Chair, MD/PhD Interview Committee, The University of Mississippi
Medical Center, Jackson, MS
2012- Member, Graduate Council Committee, The University of Mississippi
Medical Center, Jackson, MS
2015- Member, Medical Student Research Program (MSRP) Advisory Board, The
Curriculum Vitae
Page 15
Sean P. Didion, PhD, FAHA
University of Mississippi Medical Center, Jackson, MS
2012-15 Member, Office of Research, ISRP Grant Review Committee, The
University of Mississippi Medical Center, Jackson, MS
2013-15 Member, Obesity COBRE, Pilot Project Peer Review Committee, The
University of Mississippi Medical Center, Jackson, MS
2015 Member, PIN COBRE, Pilot Project Peer Review Committee, The
University of Mississippi Medical Center, Jackson, MS
2015- Member, Clinical Investigator Program (CIP) Advisory Committee, The
University of Mississippi Medical Center, Jackson, MS
2016- Member, Medical Neuroanatomy Curriculum Committee, The University of
Mississippi Medical Center, Jackson, MS
STUDENT MENTORING:
High School Students: Ria Goel, SURE Program, The University of Mississippi Medical Center
Undergraduate Students:
Pamela Fegan, The University of Iowa
Nate Newman, The University of Iowa
Anthony Taylor, The University of Iowa
Tony Serfling, The University of Iowa
Ashley Haskins, The University of Iowa
Laura Schrader, The University of Iowa
Curriculum Vitae
Page 16
Sean P. Didion, PhD, FAHA
Alexia Miller, Jackson State University
Juan Rodriquez, Mississippi State University
Leslie Miller, Jackson State University
Rotating Graduate Students:
Kathryn Brown, The University of Iowa
Andrew Johnson, The University of Iowa
Jason Davis, Medical College of Georgia
Wanwisa Promsote, Medical College of Georgia
Inger Stallmann-Jorgensen, Medical College of Georgia
Jessica Anderson, Medical College of Georgia
Yusi Wang, Medical College of Georgia
Caitlin Madigan, Medical College of Georgia
Jessica Faulkner, The University of Mississippi Medical Center
Ellen Gllis, The University of Mississippi Medical Center
Rohini Bandaru, The University of Mississippi Medical Center
Kenji Maeda, The University of Mississippi Medical Center
Graduate Student Advisee:
Jessica Gomolak PhD, The University of Mississippi Medical Center
Post-doctoral Fellow:
M. Irfan Ali, MD, PhD, Medical College of Georgia
Curriculum Vitae
Page 17
Sean P. Didion, PhD, FAHA
Medical Student Researchers:
Chelsea Pyle, Medical College of Georgia
Vijay Palvia, Medical College of Georgia
Imad Mohamed Alabdul Razzak, Alfaisal University – Saudi Arabia
Ian Coate, The University of Mississippi Medical Center
Medical Student Pre-clinical Advisees:
Edward Yang, The University of Mississippi Medical Center
Jake Wilson, The University of Mississippi Medical Center
Hunter Hood, The University of Mississippi Medical Center
Joey Golden, The University of Mississippi Medical Center
Edmond Wright, The University of Mississippi Medical Center
Tyler Howell, The University of Mississippi Medical Center
Dustin Bratton, The University of Mississippi Medical Center
Robert Browning, The University of Mississippi Medical Center
Graduate Student PhD Thesis Committee Member:
Shawn Elms, Medical College of Georgia
Ashlee Tipton, Medical College of Georgia
Jutamas Suwanpradid, Medical College of Georgia
Maha Coucha, Medical College of Georgia
Jennifer Iddings, Medical College of Georgia
Depesh Pandy, Medical College of Georgia
Xiaxiang Wang, The University of Mississippi Medical Center
Curriculum Vitae
Page 18
Sean P. Didion, PhD, FAHA
Jessica Gomolak, The University of Mississippi Medical Center
Bernadette DeRussy, The University of Mississippi Medical Center
Peter Mittwede, The University of Mississippi Medical Center
Xiao Zhang, The University of Mississippi Medical Center
BIBLIOGRAPHY: Original Papers (Peer-reviewed) 1) Mayhan WG, Didion SP. Acute effects of ethanol on responses of cerebral arterioles. Stroke. 26:2097-2101, 1995.
2) Mayhan WG, Didion SP. Activation of protein kinase C does not participate in
disruption of the blood-brain barrier to albumin during acute hypertension. Brain Res.
696:106-112, 1995.
3) Mayhan WG, Didion SP, Patel KP. L-arginine does not restore dilation of the
basilar artery during diabetes mellitus. J Cereb Blood Flow Metabol. 16:500-506,
1996.
4) Mayhan WG, Didion SP. Effect of chronic alcohol consumption on responses of
cerebral arterioles. Alcohol Clin Exper Res. 20:538-542, 1996.
5) Mayhan WG, Didion SP. Glutamate-induced disruption of the blood-brain barrier: role of nitric oxide. Stroke. 27:965-970, 1996.
6) Didion SP, Mayhan WG. Effect of chronic myocardial infarction on in vivo
reactivity of skeletal muscle arterioles. Am J Physiol. 272 (Heart Circ Physiol.
41):H2403-H2408, 1997.
Curriculum Vitae
Page 19
Sean P. Didion, PhD, FAHA
7) Didion SP, Carmines PK, Ikenaga H, Mayhan WG. Enhanced constrictor
responses of skeletal muscle arterioles during chronic myocardial infarction. Am J
Physiol. 273(Heart Circ Physiol. 42):H1502-H1508, 1997.
8) Ikenaga H, Ishii N, Didion SP, Cornish KG, Patel KP, Mayhan WG, Carmines
PK. Suppressed impact of nitric oxide on renal arteriolar function in rats with chronic
heart failure. Am J Physiol. 276(Renal Physiol. 45):F79-F87, 1999.
9) Didion SP, Sigmund CD, Faraci FM. Impaired endothelial function in transgenic
mice expressing both human renin and human angiotensinogen. Stroke. 31:760-764,
2000.
10) Didion SP, Heistad DD, Faraci FM. Mechanisms that produce nitric oxide-
mediated relaxation of cerebral arteries during atherosclerosis. Stroke. 32:761-
766,2001.
11) Didion SP, Hathaway CA, Faraci FM. Superoxide levels and function of cerebral blood vessels following inhibition of CuZnSOD. Am J Physiol Heart Circ Physiol.
281:H1697-H1703, 2001.
12) Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD. Variability of
endothelial function and blood pressure in six inbred mouse strains. Arterioscler
Thromb Vasc Biol. 22:42-48, 2002.
13) Didion SP, Faraci FM. Effects of NADH and NADPH on superoxide levels and
cerebral vascular tone. Am J Physiol Heart Circ Physiol. 282:H688-H695, 2002.
14) Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM. Superoxide
contributes to vascular dysfunction in mice that express human renin and
angiotensinogen. Am J Physiol Heart Circ Physiol. 283:H1569-H1576, 2002.
Curriculum Vitae
Page 20
Sean P. Didion, PhD, FAHA
15) Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased
superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circulation
Research. 91:938-944, 2002.
16) Didion SP, Faraci FM. Angiotensin II produces superoxide-mediated impairment
of endothelial function in cerebral arterioles. Stroke. 34:2038-2042, 2003.
17) Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPARg agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive
transgenic mice. Hypertension. 43:661-666, 2004.
18) Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. Angiotensin II induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension.
43:1074-1079, 2004.
19) Didion SP, Kinzenbaw DA, Fegan PE, Didion LA, Faraci FM. Overexpression of
CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction. Stroke. 35:1963-1967, 2004.
20) Faraci FM, Didion SP. Vascular protection: Superoxide dismutase isoforms in
the vessel wall. Arterioscler Thromb Vasc Biol. 24:1367-1373, 2004.
21) Didion SP, Faraci FM. Ceramide-induced impairment of endothelial function is
prevented by CuZnSOD overexpression. Arterioscler Thromb Vasc Biol. 25:90-95,
2005.
22) Didion SP, Lynch CM, Baumbach GL, Faraci FM. Impaired endothelium-dependent responses and enhanced influence of rho-kinase in cerebral arterioles in
type II diabetes. Stroke. 36:342-347, 2005.
Curriculum Vitae
Page 21
Sean P. Didion, PhD, FAHA
23) Didion SP, Kinzenbaw DA, Faraci FM. Critical role for CuZn-superoxide
dismutase in preventing angiotensin-II-induced endothelial dysfunction. Hypertension.
46:1147-1153, 2005.
24) Faraci FM, Modrick ML, Ryan MJ, Lamping KG, Didion SP. Cerebral vascular
effects of angiotensin II: new insights from genetic models. J Cerebral Blood Flow
Metabol. 26:449-455, 2006.
25) Faraci FM, Modrick ML, Didion LA, Fegan PE, Didion SP. Selective cerebral
vascular dysfunction in Mn-SOD deficient mice. J Appl Physiol. 100:2089-2093, 2006.
26) Baumbach GL, Didion SP, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase. Stroke. 37:1850
1855, 2006.
27) Didion SP, Kinzenbaw DA, Schrader LI, Faraci FM. Heterozygous CuZnSOD-
deficiency reveals a vascular phenotype with aging. Hypertension. 48:1072 1079,2006.
28) Didion SP, Lynch CM, Faraci FM. Cerebral vascular dysfunction in TallyHo mice:
a new model of type II diabetes. Am J Physiol Heart Circ Physiol. 292:H1579-
H1583,2007.
29) Brown K, Didion SP, Andresen JJ, Faraci FM. Effect of aging, MnSOD
deficiency, and genetic background on endothelial function: evidence for MnSOD
haplosufficiency. Arterioscler Thromb Vasc Biol. 27:1941-1946,2007.
30) Schrader LI, Kinzenbaw DA, Faraci FM, Didion SP. Interleukin-6 deficiency
protects against angiotensin II-induced endothelial dysfunction and hypertrophy.
Arterioscler Thromb Vasc Biol. 27:2576-2581,2007.
31) Chrissobolis S, Didion SP, Kinzenbaw DA, Schrader LI, Dayal S, Lentz S, Faraci
Curriculum Vitae
Page 22
Sean P. Didion, PhD, FAHA
FM. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-
induced vascular dysfunction. Hypertension. 51:872-877,2008.
32) Didion SP. Chlamydophila pnemonia and endothelial activation: The smoke that
precedes the fire of atherosclerosis? Circulation Research. 102:861-865,2008.
33) Modrick ML, Didion SP, Lynch CM, Dayal S, Lentz SR, Faraci FM. Role of
hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone. J Cereb Blood Flow Metab. 29(6):1130-7, 2009.
34) Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and
AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ
Physiol. 296(6):H1914-9,2009.
35) Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM. Endogenous
interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension.
54:619-24,2009.
36) Didion SP. Tacrolimus-induced hypertension: what’s endothelial and
hematopoietic FKBP12 got to do with it? Hypertension. 57:1058-1060, 2011.
37) Didion SP. Antioxidant 1 in hypertension: more than just a copper chaperone. Hypertension. 60:285-287, 2012.
38) Li W, Prakash R, Chawla D, Du W, Didion SP, Filosa JA, Zhang Q, Brann DW,
Lima VV, Tostes RC, Ergul A. Early effects of high fat diet on neurovascular function
and focal ischemic brain injury. Am J Physiol. Regul Integr Comp Physiol. 304:R1001-R1008, 2013.
39) Kinzenbaw DA, Chu Y, Pena Silva RA, Didion, SP, Faraci FM. Interleukin-10
protects against vascular dysfunction with aging. Physiol Rep. 1:e00149, 2013.
Curriculum Vitae
Page 23
Sean P. Didion, PhD, FAHA
40) Fan F, Sun CW, Maier KG, Williams J, Didion SP, Falck JR, Zhuo J, Roman RJ.
20-hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity
and vasoconstrictor response to angiotensin II in renal arterioles. PloS One. 8:e82482, 2013.
41) Lynch CM, Kinzenbaw D, Chen X, Zhan S, Mezzetti EM, Filosa J, Ergul A,
Faraci FM, Didion SP. Nox2-derived superoxide contributes to cerebral vascular
dysfunction in diet-induced obesity. Stroke. 44:3195-3201, 2013.
42) Gomolak JR, Didion SP. Role of innate immunity in hypertension. Med
Hypotheses. 83:640-643 ,2014.
43) Gomolak JR, Didion SP. Angiotensin II-induced endothelial dysfunction is
temporally linked with increases in interleukin-6 and vascular macrophage
accumulation. Front Physiol. 5:396, doi:10.3389/fphys.2014.00396, 2014.
44) Ali MI, Chen X, Mezzetti EM, Didion SP. Heterozygous endothelial nitric oxide synthase is associated with endothelial dysfunction in diet-induced obesity. Physiol
Reports. 3:e12630, 2015.
45) Didion SP. New insights into mechanisms associated with angiotensin II-induced
vascular hypertrophy and remodeling. Hypertension. 67:501-503, 2016.
46) McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR,
Williams JM. Early development of podocyte injury independent of hyperglycemia and
elevations in arterial pressure in non-diabetic obese Dahl SS leptin receptor mutant
rats. Am J Physiol Renal Physiol. 311:F793-F804, 2016.
47) Altara R, Didion SP, Booz GW. Conflicting mechanisms of AT2 receptor
cardioprotection revealed. Cardiovasc. Res. 112:426-428, 2016. 48) Altara R, Harmancey R, Didion SP, Booz GW, Zouein FA. Cardiac STAT3
Curriculum Vitae
Page 24
Sean P. Didion, PhD, FAHA
deficiency impairs contractility and metabolic homeostasis. Front Pharmacol. 7:436,
2016. 49) Ge Y, Fan F, Didion SP, Roman RJ. Impaired myogenic response of the afferent
arteriole contributes to the increased susceptibility to renal disease in Milan
normotensive rats. Physiol Rep. 5:e13089, 2017. 50) Didion SP. Heterozygous eNOS deficient mice as a model to examine the effects of eNOS haploinsufficiency on the cerebral circulation. J Neurol Neuromed.
2:6-9, 2017. 51) Didion SP. A novel genetic model to explore the Brenner hypothesis: Linking nephron endowment and number with hypertension. Submitted. 52) Didion SP. Heterozygous eNOS deficiency is associated with endothelial
function with age and is sex dependent. Submitted.
53) Wang X, Garrett MR, Didion SP. Direct correlation between blood pressure and
nephron endowment in a genetic mouse model of hypertension. In Preparation.
54) Didion SP. Angiotensin II contributes to both hypertension and endothelial
dysfunction in BPH2 hypertensive mice. In Preparation.
55) Didion SP. Lipopolysaccharide signaling promotes oxidative stress and
endothelial dysfunction in the vascular wall. In Preparation.
Abstracts (*=Peer-reviewed)
1) Didion SP, Morrow RJ, Stratton DB. Contractility changes induced by
endothelial disruption: Mediation by receptor-operated calcium channels. FASEB J.
8:A612, 1994.
Curriculum Vitae
Page 25
Sean P. Didion, PhD, FAHA
2) Didion SP, Zucker IH, Mayhan WG. Effect of chronic myocardial infarction on
in vivo reactivity of skeletal muscle arterioles. FASEB J. 10:A56, 1996.
3) Mayhan WG, Didion SP. Effect of glutamate on the cerebral microcirculation. FASEB J. 10:A31, 1996.
4) Didion SP, Mayhan WG. Enhanced vasoconstrictor responses of skeletal
muscle arterioles during heart failure: role of impaired synthesis/release of nitric oxide.
Microcirculation. 4:170, 1997.
5) Didion SP, Mayhan WG. Impaired endothelium-dependent response of skeletal muscle arterioles during chronic heart failure: role of oxygen radicals. FASEB
J. 11:A44, 1997.
6) Didion SP, Ishii N, Mayhan WG, Carmines PK. Attenuated nitric oxide
synthase and superoxide dismutase activities during experimental heart failure. FASEB J. 12:A380, 1998.
7) Didion SP, Sigmund CD, Faraci FM. Responses of thoracic aorta in
hypertensive mice expressing the human renin and human angiotensinogen genes.
FASEB J. 13:A512, 1999.
8) Didion SP, Faraci FM. Evidence for an NADH/NADPH oxidase in cerebral blood vessels. FASEB J. 14:A151, 2000.
9) Didion SP, Heistad DD, Faraci FM. Role of soluble guanylate cyclase and
effects of atherosclerosis on responses of cerebral arteries to nitric oxide. FASEB J.
14:A427, 2000.
10) Didion SP, Weintraub NL, Faraci FM. Mechanisms of arachidonic acid-induced relaxation in murine blood vessels. FASEB J. 14:A574, 2000.
11) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Variability of endothelial
function and blood pressure in six inbred mouse strains. FASEB J. 15:A480, 2001.
Curriculum Vitae
Page 26
Sean P. Didion, PhD, FAHA
12) Didion SP, Faraci FM. Role of endogenous CuZn-superoxide dismutase
(SOD) in the cerebral circulation. FASEB J. 15:A126, 2001.
13) Didion SP, Faraci FM. Effects of NADH on cerebral blood vessels. FASEB J. 15:A127, 2001.
14) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Severely impaired aortic
response to acetylcholine in 129/J inbred mouse strain. Hypertension. 33:134, 2001. *
15) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Heritability of impaired aortic
endothelial function in 129P3/J mice. FASEB J. 16:A880, 2002.
16) Didion SP, Faraci FM. Overexpression of CuZnSOD protects against
ceramide-induced endothelial dysfunction. FASEB J. 16:A1136, 2002.
17) Didion SP, Ryan MJ, Sigmund CD, Faraci FM. Increased superoxide and
vascular dysfunction in CuZnSOD-deficient mice. Hypertension. 40:392, 2002. *
18) Didion SP, Ryan MJ, Faraci FM, Sigmund CD. Activation of PPARg reduces
blood pressure and improves vascular function in hypertensive transgenic mice. J
Hypertension. 20(Suppl 4):S14, 2002.
19) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Rosiglitazone decreases blood
pressure and improves vascular function in transgenic mice containing human renin and human angiotensinogen. Hypertension. 40:431, 2002. *
20) Didion SP, Didion LA, Fegan PE, Faraci FM Impaired endothelium-dependent
responses in cerebral arterioles of CuZnSOD-deficient mice. Stroke. 34:251, 2003. *
21) Didion SP and Faraci FM. Angiotensin II produces superoxide-mediated
impairment of endothelial function in cerebral arterioles. Stroke. 34:272, 2003.*
22) Baumbach GL, Didion SP, Faraci FM. Deficiency of copper-zinc superoxide
dismutase promotes cerebral vascular hypertrophy. FASEB J. 17:A63, 2003.
Curriculum Vitae
Page 27
Sean P. Didion, PhD, FAHA
23) Didion SP, Ryan MJ, Sigmund CD, Faraci FM. Enhanced blood pressure
response to angiotensin II in CuZnSOD-deficient mice. FASEB J. 17:A857, 2003.
24) Didion SP, Ryan MJ, Sigmund CD, Faraci FM. PPARg activation improves endothelial function in type II diabetes. FASEB J. 17:A857, 2003.
25) Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Didion SP. Cerebral vascular
effects of angiotensin II: role of gender, rho kinase and AT1a receptors. FASEB J.
18:A1007, 2004.
26) Didion SP and Faraci FM. Vascular dysfunction in TallyHo mice: a new genetic model of type II diabetes. FASEB J. 18:A276, 2004.
27) Faraci FM, Kinzenbaw D, Didion SP. Overexpression of CuZn-SOD prevents
lipopolysaccharide-induced endothelial dysfunction. FASEB J. 18:A1319, 2004.
28) Didion SP, Lynch CM, Faraci FM. Impaired endothelium-dependent responses and enhanced function of rho-kinase in cerebral arterioles in type II diabetic
mice. FASEB J. 18:A1007, 2004.
29) Didion SP, Kinzenbaw DA, Faraci FM. Genetically-altered mice reveal a
critical role for CuZnSOD in preventing angiotensin II-induced endothelial dysfunction.
Hypertension. 44:508, 2004. *
30) Didion SP, Modrick ML, Sigmund CD, Faraci FM. Superoxide-mediated
dysfunction of cerebral arteries in transgenic mice expressing human renin and
human angiotensinogen. FASEB J. 19:A1253, 2005.
31) Brown KA, Didion SP, Andresen JJ, Faraci FM. Mn-SOD deficient mice
exhibit increased oxidative stress and vascular dysfunction with aging. FASEB J. 19:A201,2005.
32) Faraci FM, Modrick ML, Lynch C, Dayal S, Lentz SR, Didion SP. Role of
glutathione peroxidase and hydrogen peroxide in the cerebral circulation: Insight from
GPx-1 transgenic mice. Stroke. 37:686, 2006. *
Curriculum Vitae
Page 28
Sean P. Didion, PhD, FAHA
33) Didion SP, Lynch CM, Faraci FM. Endothelial dysfunction in cerebral
arterioles in a model of diet-induced obesity and type II diabetes: Role of superoxide
and NAD(P)H oxidase. FASEB J. 20:A295, 2006.
34) Didion SP, Kinzenbaw DA, Schrader LI, Faraci FM. Heterozygous Cu,Zn-
superoxide dismutase deficiency reveals a vascular phenotype with aging. FASEB J.
20:A1452-A1453, 2006.
35) Brown KA, Didion SP, Andresen JJ, Faraci FM. Effect of aging, MnSOD
deficiency and genetic background on endothelial function: evidence for haploinsufficiency. FASEB J. 2006.
36) Chrissobolis S, Didion SP, Faraci FM. Angiotensin (Ang II)-induced oxidative
stress and endothelial dysfunction in the cerebral circulation. FASEB J 20:LB15, 2006.
37) Didion SP, Kinzenbaw DA, Faraci FM. Essential role of interleukin-6 in angiotensin-II-induced endothelial dysfunction. Vascular Pharmacology. 45:e6, 2006.
38) Didion SP. Heterozygous eNOS-deficiency produces oxidative stress and
endothelial dysfunction in a model of diet-induced obesity and type II diabetes.
Hypertension. 48:e35, 2006. *
39) Chrissobolis S, Didion SP, Faraci FM. Protective role of manganese superoxide dismutase against angiotensin II-induced, Nox2-dependent, cerebral
endothelial dysfunction. FASEB J. 21:A1262,2007.
40) Faraci FM, Modrick ML, Lynch C, Dayal S, Lentz SR, Didion SP. Genetic
evidence that cerebrovascular responses to arachidonic acid are mediated by
hydrogen peroxide produced by SOD-1. FASEB J. 21:A1384;2007.
41) Didion SP, Schrader LI, Kinzenbaw DA, Faraci FM. Interleukin-6-deficiency
protects against both acute and chronic angiotensin II-induced endothelial
dysfunction. FASEB J. 21:A590,2007.
Curriculum Vitae
Page 29
Sean P. Didion, PhD, FAHA
42) Schrader LI, Kinzenbaw DA, Faraci FM, Didion SP. MnSOD
haploinsufficiency promotes oxidative stress and endothelial dysfunction in response
to a high-fat diet. Hypertension. 50:e92,2007. *
43) Chrissobolis S, Didion SP, Kinzenbaw DA, Schrader LI, Dayal S, Lentz SR,
Faraci FM. Glutathione peroxidase-1 protects against angiotensin II-induced
endothelial dysfunction. Hypertension. 50:e103,2007. *
44) Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and
angiotensin II in cerebral vascular dysfunction with aging. FASEB J. 2008 22:1151.21
45) Beyer AM, Guo DF, Didion SP, Sheffield VC, Rahmouni K. Bardet-diedel
syndrome genes are involved in the control of vascular function. Hypertension.
53:e37,2008. *
46) Didion SP, Kinzenbaw DA, Faraci FM. Interleukin-10 protects against vascular dysfunction with aging. FASEB J. 23:805.15,2009.
47) Didion SP. Heterozygous endothelial nitric oxide synthase deficiency reveals
a vascular phenotype with aging that is influenced by gender. Hypertension.
54:e42,2009. *
48) Didion SP. Heterogeneity in constrictor responses among selected inbred mouse strains: influence of rho-kinase. FASEB J. 24:986.13; 2010.
49) Didion SP, Chen X, Mezzetti EM, Ali MI. Interleukin-6 contributes to
endothelial dysfunction in the cerebral circulation in aging. FASEB J.
25:1024.26,2011.
50) Didion SP, Sarmiento JA, Mezzetti EM. Mammalian target of rapamycin (mTOR) inhibition attenuates angiotensin II-induced hypertension and endothelial
dysfunction. Hypertension. 60:A427;2012 *
Curriculum Vitae
Page 30
Sean P. Didion, PhD, FAHA
51) Palvia V, Pyle C, Mezzetti EM, Chen X, Didion SP. Toll-like receptor 4
contributes to hypertension and endothelial dysfunction produced by angiotensin II.
FASEB J. 25:1024.26,2012
52) Gomolak JR, Faulkner J, Didion SP. Temporal effects of chronic angiotensin
II infusion on blood pressure and vascular function. FASEB J. 27:654.22,2013.
53) Faulkner J, Gomolak JR, Garrett MR, Didion SP. Differential gene expression
profiles produced by a high fat diet in white and brown adipose. FASEB J.
27:738.3,2013.
54) Gomolak JR, Faulkner J, Didion SP. Myloid differentiation factor 88 (MYD88)
does not contribute to hypertension or endothelial dysfunction produced by
angiotensin II. FASEB J. 27:1131.15,2013.
55) Faulkner J, Gomolak JR, Didion SP. Interleukin-10 deficiency limits the development of obesity and insulin resistance produced by a high fat diet. FASEB J.
27:1183.6,2013.
56) Didion SP. Nox2 deficiency limits the development of insulin resistance
produced by a high-fat diet. FASEB J. 27:1192.21,2013.
57) Faulkner JF, Hall JE, Garrett MR, Didion SP. Upregulation of GPR50 in a white adipose depot of diet-induced obese mice requires intact leptin signaling. FASEB J.
28:711.11,2014.
58) Didion SP, Mezzetti EM, Garrett MR. Effect of a high salt diet on endothelial
function and blood pressure in a genetic model of hypertension. J Hypertens.
59) Didion SP. Unholy fire: Discovering Michael Servetus’ contribution to pulmonary physiology through modern historical fiction. FASEB J. 29:1028.1, 2015.
60) Didion SP. Role of increased Serine1176 phosphorylation in maintaining
normal endothelial responses in male and female heterozygous endothelial nitric
oxide synthase (NOS)-deficient mice. FASEB J. 29:1047.6, 2015.
Curriculum Vitae
Page 31
Sean P. Didion, PhD, FAHA
61) Didion SP, Sims JD, Baldwin ZK. Myeloid differentiation factor-88 deficiency
protects against lipopolysaccharide-induced endothelial dysfunction. FASEB J.
29:625.3, 2015.
62) Didion SP. Interleukin-6 produces oxidative stress and endothelial dysfunction in
the absence of a single endothelial nitric oxide synthase gene. FASEB J. 29:971.10,
2015.
63) Didion SP. Deficiency of vascular TLR4 protects against lipopolysaccharide-
induced endothelial dysfunction and NADPH-oxidase-derived superoxide. FASEB J. 30:1260.10, 2016.
64) Didion SP. Nitric oxide and soluble guanylyl cyclase mediate endothelial
responses in aged female endothelial nitric oxide synthase (eNOS)-deficient mice.
FASEB J. 30:738.1, 2016.
65) Wang X, Garrett MR, Didion SP. Direct correlation between blood pressure
and nephron endowment in a genetic mouse model of hypertension. Hypertension.
68:A052, 2016.
Book Chapters: Didion SP, Chrissobolis S, Faraci FM. Oxidative stress in hypertension. In Oxidative
Stress in Aging. Edited by Miwa S, Beckman KB, and Muller FL. Springer 2008.
Theses: Didion SP. “The role of the endothelium on calcium mobilization in rat aortic smooth
muscle in response to phenylephrine, serotonin, and endothelin-1.” In partial
fulfillment for the MA degree.
Didion SP. “The effect of chronic heart failure on responses of skeletal muscle
arterioles.” In partial fulfillment for the PhD degree.
Curriculum Vitae
Page 32
Sean P. Didion, PhD, FAHA
FELLOWSHIP AND FEDERAL GRANT SUPPORT
Completed:
1994 Pre-doctoral Fellowship, “Heart Failure and the Microcirculation”,
American Heart Association, Heartland Affiliate (940491S), Salary
Support Only.
1995 Pre-doctoral Fellowship, “Endothelial Dysfunction of the Microcirculation
During Heart Failure”, American Heart Association, Heartland Affiliate
(954027S), Salary Support Only.
1996 Pre-doctoral Fellowship, “Neuropeptides and the Microcirculation during
Heart Failure”, American Heart Association, Heartland Affiliate
(9604027S), Salary Support Only.
1999-2001 Principal Investigator, “Vascular Responses in Transgenic Hypertensive Mice”, National Institutes of Health, Individual National Research Service
Award (HL-10237), Salary Support Only.
2002 Principal Investigator, University of Iowa Diabetes & Endocrinology
Center Pilot and Feasibility Grant, National Institutes of Health (DK-25295), $20,000.
2002-2005 Principal Investigator, “Role of PPARg in Vascular Function During
Diabetes Mellitus”, American Heart Association, National Scientist
Development Award (0230327N), $260,000.
2005-2008 Principal Investigator, “Cerebral Vascular Dysfunction in Response to a
High-Fat Diet”, American Heart Association, Heartland Affiliate Grant-In-
Aid (0565486Z). $143,000.
Curriculum Vitae
Page 33
Sean P. Didion, PhD, FAHA
2006-2011 Co-Investigator, Project 1: “Vascular Protection During Hypertension:
Inflammatory Mechanisms.” NIH/NHLBI Program Project Grant (HL-
62984): “Oxidative Mechanisms in Vascular Disease”; Principal Investigator, Donald D. Heistad.
2010-2012 Principal Investigator, American Heart Association Southeast Affiliate,
Grant-In-Aid. “Mechanisms of Endothelial Dysfunction in Obesity.”
*Awarded but returned due to scientific overlap with R01-HL089884.
2010-2015 Principal Investigator, “Mechanisms of Vascular Dysfunction in Diet-
Induced Obesity” NIH/NHLBI (R01-HL089884). $250,000/yr direct costs.
Current: NIH/NHLBI (R01-HL107632) – Didion (PI)
“Molecular Mechanisms of Hypertension in the Microcirculation”
Period: 5/2011-5/2017 on NCE
Role: Principal Investigator $250,000/yr direct costs.
National Institutes of Health/NIBIB (R01-EB020006) – Janorkar (PI)
“3D Spheroid Model of Adipose Pathophysiology”
Period: 9/2016-8/2021 Role: Co-Investigator
Direct Costs: $250,000/yr
Pending: NIH/NHLBI (R01-HL138106)- Didion (PI)
“Cardiovascular Inflammation and Circadian Disruption”
Period: 05/01/17-04/30/2022
Role: Principal Investigator (25% effort)
$250,000/yr direct costs
Curriculum Vitae
Page 34
Sean P. Didion, PhD, FAHA
NIH/NHLBI (R01-HL137883)- Booz (PI)
“Transition from Endothelial Inflammation to Diastolic Dysfunction in HFpEF”
Period: 05/01/17-04/30/2022
Role: Co-Investigator (5% effort)
$250,000/yr direct costs
NIH/NHLBI (R01-HL137789)- Pabbidi (PI)
“Mechanisms Underlying Cerebrovascular Function: Role of
Gender and Age”
Period: 05/01/17-04/30/2022 Role: Co-Investigator (5% effort)
$250,000/yr direct costs
NIH/NHLBI (R01-HL13726)- Garrett (PI)
“Genetic Targets of Hypertension End Organ Damage” Period: 05/01/17-04/30/2022
Role: Co-Investigator (5% effort)
$250,000/yr direct costs
June 2017