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Curriculum Vitae Name: Sean Patrick Didion, PhD, FAHA Campus Address: The University of Mississippi Medical Center Departments of Pharmacology and Neurology Arthur C. Guyton Laboratory Research Building 2500 North State Street Jackson, Mississippi 39216 Phone: (601)-984-1710 Email: [email protected] Marital Status: Married: Lisa Ann Didion, MD, FAAP Associate Professor & Chief Medical Officer Director, Office of Patient Satisfaction Batson Children’s Hospital Department of Pediatrics University of Mississippi Medical Center Jackson, Mississippi 39216 Children: Riley Ann, 13 years Andrew James, 11 years Colin Patrick, 8 years Mairead Emma, 7 years EDUCATION: Year Degree Institution Major 1991 B.S. Drake University Biology 1994 M.A. Drake University Biology 1998 Ph.D. University of Nebraska Molecular and Cellular Physiology

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Page 1: Didion CV 070217 and Offices/SOM...in Medical, Dental, and Graduate Pharmacology courses has been extremely positive. Dr. Didion has also been recognized for his efforts to raise-the-bar

Curriculum Vitae

Name: Sean Patrick Didion, PhD, FAHA

Campus Address: The University of Mississippi Medical Center Departments of Pharmacology and Neurology

Arthur C. Guyton Laboratory Research Building

2500 North State Street

Jackson, Mississippi 39216

Phone: (601)-984-1710 Email: [email protected]

Marital Status: Married: Lisa Ann Didion, MD, FAAP

Associate Professor & Chief Medical Officer

Director, Office of Patient Satisfaction Batson Children’s Hospital

Department of Pediatrics

University of Mississippi Medical Center

Jackson, Mississippi 39216

Children: Riley Ann, 13 years

Andrew James, 11 years

Colin Patrick, 8 years

Mairead Emma, 7 years

EDUCATION:

Year Degree Institution Major 1991 B.S. Drake University Biology

1994 M.A. Drake University Biology

1998 Ph.D. University of Nebraska Molecular and Cellular Physiology

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Curriculum Vitae

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Sean P. Didion, PhD, FAHA

ACADEMIC POSITIONS:

1998-2002 Post-doctoral Fellow, Department of Internal Medicine, Division of

Cardiovascular Medicine, The University of Iowa

2002-2003 Assistant Research Scientist, Department of Internal Medicine, Division

of Cardiovascular Medicine, The University of Iowa

2003-2005 Associate Research Scientist, Department of Internal Medicine, Division

of Cardiovascular Medicine, The University of Iowa

2006-2008 Research Scientist, Department of Internal Medicine, Division of Cardiovascular Medicine, The University of Iowa

2009-2011 Assistant Professor, Department of Neurology and The Vascular Biology

Center, Medical College of Georgia

2011- Associate Professor, Departments of Pharmacology and Neurology, The

University of Mississippi Medical Center

2012-2014 Associate Director, Department of Pharmacology Graduate Program,

The University of Mississippi Medical Center

2012- Director, MD/PhD Program, The University of Mississippi Medical Center

2015- Associate Professor with Tenure, Departments of Pharmacology and

Neurology, The University of Mississippi Medical Center

Brief Biography: Dr. Sean P. Didion, Ph.D. is an Associate Professor in the

Departments of Pharmacology and Neurology at the University of Mississippi Medical

Center (UMMC) in Jackson, MS. He received his B.S. and M.A. degrees in Biological

Sciences from Drake University and his Ph.D. degree in Physiology under the

mentorship of Dr. William G. Mayhan, PhD in the department of Cellular and

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Curriculum Vitae

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Sean P. Didion, PhD, FAHA

Molecular Physiology (chaired by Dr. Irving H. Zucker, PhD) from The University of

Nebraska Medical Center. His postdoctoral training was conducted at the University of

Iowa Carver College of Medicine under the mentorship of Dr. Frank M. Faraci, PhD. Dr. Didion's current research is focused on understanding mechanisms by oxidative

stress and inflammatory molecules play in the impairment of vascular function in

development of obesity and hypertension. Dr. Didion has maintained an uninterrupted

track record of funding as a Principal Investigator, which has totaled nearly $9 million

(approx. $3 million as Principal Investigator) to date. Dr. Didion's work is currently funded by 2 R01's from the National Institutes of Health. In recognition of his research,

he received the UMMC Gold Medal for Excellence in Research in 2012. He is an

active member of the APS, having served on the Membership Committee and Perkins

Memorial Award Committees. Dr. Didion has served on the Editorial Boards of the leading cardiovascular journals in his field, including, Atherosclerosis, Thrombosis,

and Vascular Biology, Circulation Research, and Hypertension. Dr. Didion is a 2014

graduate of the UMMC Leadership Development Program and is the director of the

UMMC MD/PhD Program. Dr. Didion's wife, Dr. Lisa A. Didion, MD, is an Associate Professor in the Departmen

of Pediatrics and Associate Chief Medical Officer of Children's of Mississippi. They

have 4 children and currently live in Madison, MS.

Teaching and Education: Evaluation of Dr. Didion's course directorship and teaching in Medical, Dental, and Graduate Pharmacology courses has been extremely positive.

Dr. Didion has also been recognized for his efforts to raise-the-bar by recruiting

nationally recognized speakers to the Pharmacology Seminar Series and he was

instrumental in ensuring that the departmental seminar series meet on a weekly basis.

In addition, Dr. Didion established a weekly Journal Club series to the Department of Pharmacology thereby bringing faculty, students and trainees together to discuss the

most recent advances, topics and papers in the field of Pharmacology. Dr. Didion

worked to ensure that faculty as part of their education evaluated students and

trainees. Dr. Didion has also worked to formalize many of the educational components

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Curriculum Vitae

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Sean P. Didion, PhD, FAHA

related to the MD-PhD program, all of which has been well received by students and

faculty alike.

Administrative Expertise and Interests: Dr. Didion fulfills a number of service-

related roles both at the departmental and institutional levels, but also at the national

and international level with his involvement in the National Association of MD-PhD

Directors and the AAMC GREAT Group. Dr. Didion is working toward developing

innovative methods for the education and training of physician-scientists and looks to bring his ideas to the national arena, as training and development of future physician-

scientists is one of Dr. Didion’s passions.

Services and Procedures: Dr. Didion is currently the Director of Histological Services for the Department of Pharmacology. Services provided by Dr. Didion include, tissue

processing, sectioning of paraffin embedded tissues as well as fixation of fresh frozen

tissues. Dr. Didion provides routine histological staining of paraffin-fixed tissues,

including H&E, Masson’s Tri-chrome, PAS. Services also provided by Dr. Didion

included specialized immunohistochemistry techniques. Dr. Didion also provides image and data analysis and quantification. This is a major service that Dr. Didion

provides to the Department of Pharmacology and it is estimated that as of January

2016 to date Dr. Didion has processed well over 5,000+ tissue samples and more

than 12,000+ individual slides for departmental faculty.

AWARDS & HONORS:

1994-1997 American Heart Association Pre-Doctoral Fellowship

1996 Procter & Gamble Professional Opportunity Award, Cardiovascular Section, American Physiological Society

1996 1st Place Basic Science Oral Presentation, Student Research Forum,

University of Nebraska Medical Center

1997-1998 Blanche Widaman Fellowship & Regents Tuition Fellowship, University of Nebraska Medical Center

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Curriculum Vitae

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Sean P. Didion, PhD, FAHA

1998 Alice Cummings Prize in Physiology (Top Physiology Student Award),

University of Nebraska Medical Center

1998-1999 Institutional Research Fellowship, The University of Iowa, National

Institutes of Health (HL-07121-23)

2000-2001 Individual National Research Service Award, National Institutes of Health (HL-

10237-01)

2002-2005 Scientist Development Award, American Heart Association, National Affiliate

2002 Young Investigator Award, International Society of Hypertension

2002 Merck New Investigator Award, High Blood Pressure Council, American Heart

Association

2006 Young Scholar Award, American Society of Hypertension

2009 Recognized as a Superior Editorial Consultant for Circulation Research

2012 Fellow of the American Heart Association, High Blood Pressure Council

2012 Gold Medal in Research Excellence Award, University of Mississippi

Medical Center

2017 5 Year Service Award, National Association of MD-PhD Programs

PROFESSIONAL SOCIETIES:

1993- American Association for the Advancement of Science

1996- American Physiological Society

2001- Member, Stroke Council, American Heart Association

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Curriculum Vitae

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Sean P. Didion, PhD, FAHA

2001- Member, Council on Basic Cardiovascular Sciences, American Heart

Association

2002- Member, High Blood Pressure Council, American Heart Association

2004- Member, North American Vascular Biology Organization

2006-2008 American Society of Hypertension

2012- Member, American Society for Pharmacology and Experimental

Therapeutics

2013- Member, Society for Free Radical Biology and Medicine

2015- Life Member, Mississippi Academy of Sciences

2015- Member, American Association of University Professors

PROFESSIONAL SERVICE:

2006-2010 National Peer Review, Vascular Biology and Blood Pressure Regulation Committee, American Heart Association

2009-2011 Medical College of Georgia, Vascular Biology Center Post-Doctoral

Fellow Review Committee Member

2010-2014 Member, American Physiological Society, Membership Committee Member

2013- Member, National American Heart Association Vascular Biology and

Blood Pressure Regulation Study Section

2014- Member, American Physiological Society, Perkins Memorial Fund

Committee

2015 Ad Hoc Member, Diabetes United Kingdom, Grant Review Committee

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Sean P. Didion, PhD, FAHA

2015 Member, Cardiovascular Health One, National Peer Reviewed Medical

Research Program, Department of Defense Congressionally Directed

Medical Research Programs

2016- Member, Vascular Malformations, National Peer Reviewed Medical

Research Program, Department of Defense Congressionally Directed

Medical Research Programs

EDITORIAL BOARDS:

2006-2013 Circulation Research

2007- Hypertension

2010- Frontiers in Physiology - Oxidant Physiology

2010-2012 Atherosclerosis, Thrombosis, and Vascular Biology

2012-2015 American Journal of Cardiovascular Disease

2013- Frontiers in Physiology - Cardiac Electrophysiology

2016- Journal of Hypertension

AD HOC REVIEWER FOR JOURNALS:

American Journal of Physiology – Heart and Circulatory Physiology

American Journal of Physiology – Regulatory and Integrative Physiology

Antioxidants and Redox Signaling

Atherosclerosis, Thrombosis and Vascular Biology (ATVB)

Basic & Clinical Pharmacology & Toxicology

Biochimica et Biophysica Acta – Molecular Basis of Disease

Biological Research for Nursing

Brain Research

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Sean P. Didion, PhD, FAHA

British Journal of Pharmacology

Circulation

Circulation Research

Coronary Artery Disease

Current Medicinal Chemistry

Diabetes

Diabetes Care

Diabetic Medicine

FASEB Journal

FEBS Letters

Free Radical Biology and Medicine

Frontiers: Cardiovascular Medicine

Hypertension

Journal of the American Heart Association

Journal of Applied Physiology

Journal of Hypertension

Journal of Hypertension Research

Journal of Molecular Histology

Life Sciences

Microcirculation

Microvascular Research

Molecular Neurobiology

Pharmacological Research

Public Library of Science (PLoS) One

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Sean P. Didion, PhD, FAHA

Stroke

Translational Research

Vascular Pharmacology

INVITED LECTURES:

2004 Department of Pathology, “Vascular Protection: Role of Superoxide Dismutase and PPAR-gamma”, Weill Medical College, Cornell

University, New York, New York

2004 Department of Cellular and Molecular Physiology, “Mechanisms of Oxidative Stress and Protection in the Vasculature”, University of North

Carolina, Chapel Hill, North Carolina

2004 Department of Physiology, “Oxidative Stress and Vascular Function”,

University of Mississippi Medical Center, Jackson, Mississippi

2004 Department of Physiology, “Role of CuZn-Superoxide Dismutase in

Vascular Protection”, West Virginia University, Morgantown, West

Virginia

2006 Winter Conference on Brain Research, “Super Size Me: Vascular

Responses in the Cerebral Circulation in Obesity and Type II Diabetes”,

Steamboat Springs, Colorado

2006 American Society of Hypertension, Young Scholar Award Lecture, “Vascular Dysfunction in Obesity and Type II Diabetes: New

Perspectives from Genetic Models”, New York, New York

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Sean P. Didion, PhD, FAHA

2006 Neuroscience Program, “Role of Superoxide Dismutases in Limiting

Cerebral Vascular Dysfunction”, Michigan State University, East

Lansing, Michigan

2006 Department of Neurology Grand Rounds, “Role of Superoxide

Dismutases in Limiting Cerebral Vascular Dysfunction”, University of

Iowa Hospital and Clinics, Iowa City, Iowa

2007 23rd International Symposium on Cerebral Blood Flow and Metabolism,

“The Role of Oxidative Stress in the Cerebral Circulation”, Osaka, Japan

2007 Center for Cardiovascular Sciences, “Oxidative and Inflammatory Mechanisms Associated with Cerebral Vascular Dysfunction”, Albany

Medical College, Albany, New York

2007 Iowa and Nebraska Physiology Societies Combined Meeting, “Genetic

Deficiency of Interleukin-6 Protects Against Angiotensin II Induced Endothelial Dysfunction and Hypertrophy”, Nebraska City, Nebraska

2007 Vascular Biology Center, “Oxidative and Inflammatory Mechanisms

Associated with Cerebral Vascular Dysfunction”, Medical College of

Georgia, Augusta, Georgia

2008 Department of Cellular and Molecular Physiology, “Oxidative Stress,

Inflammation, and Angiotensin Too”, University of Nebraska Medical

Center, Omaha, NE

2010 Vascular Biology Center, “Stress, Strain, and Angiotensin II: Let’s

Rho’ll”, Medical College of Georgia, Augusta, GA

2010 Department of Pharmacology, “Inflammatory Mechanisms of Aging and Hypertension”, University of Mississippi Medical Center, Jackson, MS

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Sean P. Didion, PhD, FAHA

2010 Department of Cellular and Molecular Physiology, “Inflammatory

Mechanisms of Hypertension”, Loyola University Stritch School of Medicine, Maywood, IL

2010 Department of Medicine, Division of Cardiovascular Medicine,

“Inflammatory Mechanisms of Endothelial Dysfunction: Insights from IL-6

and IL-10”, University of Cincinnati, Cincinnati, OH

2011 Department of Health and Human Physiology, “Vascular Dysfunction in

Aging and Hypertension: A Pro-Inflammatory Role for Interleukin-6”, The

University of Iowa, Iowa City, IA

2013 Department of Physiology, “Vascular Phenotypes and Whole Genome

Profiles in Obesity: The Mirrored Maze of Mouse Models”, The

University of Mississippi Medical Center, Jackson, MS

2014 Department of Pharmacology, “Hypertension, Endothelial Dysfunction

and Angiotensin Too”, The University of Mississippi Medical Center,

Jackson, MS

2014 Department of Physiology, “Inflammation, Endothelial Dysfunction and Angiotensin II”, Tulane University, New Orleans, LA

2016 Center for Cardiovascular and Renal Research, “Novel Genetic Mouse

Model of Hypertension”, The University of Mississippi Medical Center,

Jackson, MS

2016 AAMC GREAT and GRAND Group Meeting, “Shaping the Future of the

Physician-Scientist Workforce: Enhancing Pre-doctoral Fellowship

Success Rates through a Proactive and Team-based Approach, Chicago, IL

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Sean P. Didion, PhD, FAHA

TEACHING ACTIVITIES: (Classroom, Laboratory and Journal Club)

1991-1992 Laboratory Instructor, Biology I for Majors, Drake University, Des Moines, Iowa

1992-1993 Laboratory Instructor, Biology II for Majors, Drake University, Des Moines, Iowa

1991-1992 Laboratory Instructor, Comparative Anatomy, Drake University, Des Moines,

Iowa

1993-1998 Cardiovascular Journal Club, Department of Physiology, University of Nebraska

Medical Center, Omaha, Nebraska

1993-1994 Neuroscience Journal Club, Department of Pharmacology, University of

Nebraska Medical Center, Omaha, Nebraska

1995-1996 Medical Physiology - Radiation Technology Students, Endocrinology and

Reproductive Physiology, University of Nebraska Medical Center

1998-2008 Cardiovascular Journal Club, Department of Internal Medicine, The University

of Iowa, Iowa City, Iowa

2005-2008 Free Radical Journal Club, Department of Free Radical Biology, The

University of Iowa, Iowa City, IA

2009-2011 VBI 8020: Frontiers in Vascular Biology (2 contact hours), The Medical College

of Georgia, Augusta, GA

2010-2011 VBI 9020: Vascular Biology Journal Club (28 contact hrs), Course Director, The

Medical College of Georgia, Augusta, GA

2010-2011 VBI 9020: Vascular Biology Journal Club (1 Credit Hr/Semester), Course

Director, The Medical College of Georgia, Augusta, GA

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Sean P. Didion, PhD, FAHA

2012-2014 PHARM 701: Pharmacology Seminar (28 contact hrs), Course Director, The

University of Mississippi Medical Center, Jackson, MS

2012-2014 PHARM 702: Pharmacology Journal Club (28 contact hrs), Course Director,

The University of Mississippi Medical Center, Jackson, MS

2012-2014 ID 727: Current Issues in Biomedical Research (2 contact hrs), The University

of Mississippi Medical Center, Jackson, MS

2012- PHARM 620: Introduction to Pharmacology and Therapeutics (6 contact hrs)

2012- PHARM 626: Dental Pharmacology (3 contact hrs), The University of

Mississippi Medical Center, Jackson, MS

2012- PHARM 723: Mechanisms of Drug Action (4 contact hrs), The University of

Mississippi Medical Center, Jackson, MS

2016- PHARM 724: Experimental Design & Methods to Study Cell Signaling (3

contact hrs), The University of Mississippi Medical Center, Jackson, MS

2016- MD-PhD Journal Club (12 contact hrs), The University of Mississippi Medical

Center, Jackson, MS

DEPARTMENTAL SERVICE:

2009-2011 Medical College of Georgia, Vascular Biology Center Post-Doctoral

Fellow Review Committee Member

2012-2014 Director, Seminar Program, Department of Pharmacology, The University of

Mississippi Medical Center, Jackson, MS

2012-2014 Director, Journal Club, Department of Pharmacology, The University of

Mississippi Medical Center, Jackson, MS

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Sean P. Didion, PhD, FAHA

2012-2014 Associate Director, Pharmacology Graduate Program, Department of

Pharmacology, The University of Mississippi Medical Center, Jackson, MS

2016 Member, Departmental Review Committee, Department of Pharmacology, The

University of Mississippi Medical Center, Jackson, MS

2012-2015 Member, Graduate Program Committee, Department of Pharmacology, The

University of Mississippi Medical Center, Jackson, MS

2015- Member, Faculty Recruitment Committee, Department of Pharmacology, The

University of Mississippi Medical Center, Jackson, MS

2016- Member, Faculty Strategic Planning Committee, Department of Pharmacology,

The University of Mississippi Medical Center, Jackson, MS

2017- Member, Professional Education Committee, Department of Pharmacology,

The University of Mississippi Medical Center, Jackson, MS

INSTITUTIONAL SERVICE:

2009 Member, Medical Library Director Search Committee, The Medical College of

Georgia

2012- Chair, MD/PhD Program Advisory Board, The University of Mississippi

Medical Center, Jackson, MS

2012- Chair, MD/PhD Interview Committee, The University of Mississippi

Medical Center, Jackson, MS

2012- Member, Graduate Council Committee, The University of Mississippi

Medical Center, Jackson, MS

2015- Member, Medical Student Research Program (MSRP) Advisory Board, The

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Sean P. Didion, PhD, FAHA

University of Mississippi Medical Center, Jackson, MS

2012-15 Member, Office of Research, ISRP Grant Review Committee, The

University of Mississippi Medical Center, Jackson, MS

2013-15 Member, Obesity COBRE, Pilot Project Peer Review Committee, The

University of Mississippi Medical Center, Jackson, MS

2015 Member, PIN COBRE, Pilot Project Peer Review Committee, The

University of Mississippi Medical Center, Jackson, MS

2015- Member, Clinical Investigator Program (CIP) Advisory Committee, The

University of Mississippi Medical Center, Jackson, MS

2016- Member, Medical Neuroanatomy Curriculum Committee, The University of

Mississippi Medical Center, Jackson, MS

STUDENT MENTORING:

High School Students: Ria Goel, SURE Program, The University of Mississippi Medical Center

Undergraduate Students:

Pamela Fegan, The University of Iowa

Nate Newman, The University of Iowa

Anthony Taylor, The University of Iowa

Tony Serfling, The University of Iowa

Ashley Haskins, The University of Iowa

Laura Schrader, The University of Iowa

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Sean P. Didion, PhD, FAHA

Alexia Miller, Jackson State University

Juan Rodriquez, Mississippi State University

Leslie Miller, Jackson State University

Rotating Graduate Students:

Kathryn Brown, The University of Iowa

Andrew Johnson, The University of Iowa

Jason Davis, Medical College of Georgia

Wanwisa Promsote, Medical College of Georgia

Inger Stallmann-Jorgensen, Medical College of Georgia

Jessica Anderson, Medical College of Georgia

Yusi Wang, Medical College of Georgia

Caitlin Madigan, Medical College of Georgia

Jessica Faulkner, The University of Mississippi Medical Center

Ellen Gllis, The University of Mississippi Medical Center

Rohini Bandaru, The University of Mississippi Medical Center

Kenji Maeda, The University of Mississippi Medical Center

Graduate Student Advisee:

Jessica Gomolak PhD, The University of Mississippi Medical Center

Post-doctoral Fellow:

M. Irfan Ali, MD, PhD, Medical College of Georgia

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Sean P. Didion, PhD, FAHA

Medical Student Researchers:

Chelsea Pyle, Medical College of Georgia

Vijay Palvia, Medical College of Georgia

Imad Mohamed Alabdul Razzak, Alfaisal University – Saudi Arabia

Ian Coate, The University of Mississippi Medical Center

Medical Student Pre-clinical Advisees:

Edward Yang, The University of Mississippi Medical Center

Jake Wilson, The University of Mississippi Medical Center

Hunter Hood, The University of Mississippi Medical Center

Joey Golden, The University of Mississippi Medical Center

Edmond Wright, The University of Mississippi Medical Center

Tyler Howell, The University of Mississippi Medical Center

Dustin Bratton, The University of Mississippi Medical Center

Robert Browning, The University of Mississippi Medical Center

Graduate Student PhD Thesis Committee Member:

Shawn Elms, Medical College of Georgia

Ashlee Tipton, Medical College of Georgia

Jutamas Suwanpradid, Medical College of Georgia

Maha Coucha, Medical College of Georgia

Jennifer Iddings, Medical College of Georgia

Depesh Pandy, Medical College of Georgia

Xiaxiang Wang, The University of Mississippi Medical Center

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Sean P. Didion, PhD, FAHA

Jessica Gomolak, The University of Mississippi Medical Center

Bernadette DeRussy, The University of Mississippi Medical Center

Peter Mittwede, The University of Mississippi Medical Center

Xiao Zhang, The University of Mississippi Medical Center

BIBLIOGRAPHY: Original Papers (Peer-reviewed) 1) Mayhan WG, Didion SP. Acute effects of ethanol on responses of cerebral arterioles. Stroke. 26:2097-2101, 1995.

2) Mayhan WG, Didion SP. Activation of protein kinase C does not participate in

disruption of the blood-brain barrier to albumin during acute hypertension. Brain Res.

696:106-112, 1995.

3) Mayhan WG, Didion SP, Patel KP. L-arginine does not restore dilation of the

basilar artery during diabetes mellitus. J Cereb Blood Flow Metabol. 16:500-506,

1996.

4) Mayhan WG, Didion SP. Effect of chronic alcohol consumption on responses of

cerebral arterioles. Alcohol Clin Exper Res. 20:538-542, 1996.

5) Mayhan WG, Didion SP. Glutamate-induced disruption of the blood-brain barrier: role of nitric oxide. Stroke. 27:965-970, 1996.

6) Didion SP, Mayhan WG. Effect of chronic myocardial infarction on in vivo

reactivity of skeletal muscle arterioles. Am J Physiol. 272 (Heart Circ Physiol.

41):H2403-H2408, 1997.

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Sean P. Didion, PhD, FAHA

7) Didion SP, Carmines PK, Ikenaga H, Mayhan WG. Enhanced constrictor

responses of skeletal muscle arterioles during chronic myocardial infarction. Am J

Physiol. 273(Heart Circ Physiol. 42):H1502-H1508, 1997.

8) Ikenaga H, Ishii N, Didion SP, Cornish KG, Patel KP, Mayhan WG, Carmines

PK. Suppressed impact of nitric oxide on renal arteriolar function in rats with chronic

heart failure. Am J Physiol. 276(Renal Physiol. 45):F79-F87, 1999.

9) Didion SP, Sigmund CD, Faraci FM. Impaired endothelial function in transgenic

mice expressing both human renin and human angiotensinogen. Stroke. 31:760-764,

2000.

10) Didion SP, Heistad DD, Faraci FM. Mechanisms that produce nitric oxide-

mediated relaxation of cerebral arteries during atherosclerosis. Stroke. 32:761-

766,2001.

11) Didion SP, Hathaway CA, Faraci FM. Superoxide levels and function of cerebral blood vessels following inhibition of CuZnSOD. Am J Physiol Heart Circ Physiol.

281:H1697-H1703, 2001.

12) Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD. Variability of

endothelial function and blood pressure in six inbred mouse strains. Arterioscler

Thromb Vasc Biol. 22:42-48, 2002.

13) Didion SP, Faraci FM. Effects of NADH and NADPH on superoxide levels and

cerebral vascular tone. Am J Physiol Heart Circ Physiol. 282:H688-H695, 2002.

14) Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM. Superoxide

contributes to vascular dysfunction in mice that express human renin and

angiotensinogen. Am J Physiol Heart Circ Physiol. 283:H1569-H1576, 2002.

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15) Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased

superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circulation

Research. 91:938-944, 2002.

16) Didion SP, Faraci FM. Angiotensin II produces superoxide-mediated impairment

of endothelial function in cerebral arterioles. Stroke. 34:2038-2042, 2003.

17) Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPARg agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive

transgenic mice. Hypertension. 43:661-666, 2004.

18) Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. Angiotensin II induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension.

43:1074-1079, 2004.

19) Didion SP, Kinzenbaw DA, Fegan PE, Didion LA, Faraci FM. Overexpression of

CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction. Stroke. 35:1963-1967, 2004.

20) Faraci FM, Didion SP. Vascular protection: Superoxide dismutase isoforms in

the vessel wall. Arterioscler Thromb Vasc Biol. 24:1367-1373, 2004.

21) Didion SP, Faraci FM. Ceramide-induced impairment of endothelial function is

prevented by CuZnSOD overexpression. Arterioscler Thromb Vasc Biol. 25:90-95,

2005.

22) Didion SP, Lynch CM, Baumbach GL, Faraci FM. Impaired endothelium-dependent responses and enhanced influence of rho-kinase in cerebral arterioles in

type II diabetes. Stroke. 36:342-347, 2005.

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Sean P. Didion, PhD, FAHA

23) Didion SP, Kinzenbaw DA, Faraci FM. Critical role for CuZn-superoxide

dismutase in preventing angiotensin-II-induced endothelial dysfunction. Hypertension.

46:1147-1153, 2005.

24) Faraci FM, Modrick ML, Ryan MJ, Lamping KG, Didion SP. Cerebral vascular

effects of angiotensin II: new insights from genetic models. J Cerebral Blood Flow

Metabol. 26:449-455, 2006.

25) Faraci FM, Modrick ML, Didion LA, Fegan PE, Didion SP. Selective cerebral

vascular dysfunction in Mn-SOD deficient mice. J Appl Physiol. 100:2089-2093, 2006.

26) Baumbach GL, Didion SP, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase. Stroke. 37:1850

1855, 2006.

27) Didion SP, Kinzenbaw DA, Schrader LI, Faraci FM. Heterozygous CuZnSOD-

deficiency reveals a vascular phenotype with aging. Hypertension. 48:1072 1079,2006.

28) Didion SP, Lynch CM, Faraci FM. Cerebral vascular dysfunction in TallyHo mice:

a new model of type II diabetes. Am J Physiol Heart Circ Physiol. 292:H1579-

H1583,2007.

29) Brown K, Didion SP, Andresen JJ, Faraci FM. Effect of aging, MnSOD

deficiency, and genetic background on endothelial function: evidence for MnSOD

haplosufficiency. Arterioscler Thromb Vasc Biol. 27:1941-1946,2007.

30) Schrader LI, Kinzenbaw DA, Faraci FM, Didion SP. Interleukin-6 deficiency

protects against angiotensin II-induced endothelial dysfunction and hypertrophy.

Arterioscler Thromb Vasc Biol. 27:2576-2581,2007.

31) Chrissobolis S, Didion SP, Kinzenbaw DA, Schrader LI, Dayal S, Lentz S, Faraci

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FM. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-

induced vascular dysfunction. Hypertension. 51:872-877,2008.

32) Didion SP. Chlamydophila pnemonia and endothelial activation: The smoke that

precedes the fire of atherosclerosis? Circulation Research. 102:861-865,2008.

33) Modrick ML, Didion SP, Lynch CM, Dayal S, Lentz SR, Faraci FM. Role of

hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone. J Cereb Blood Flow Metab. 29(6):1130-7, 2009.

34) Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and

AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ

Physiol. 296(6):H1914-9,2009.

35) Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM. Endogenous

interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension.

54:619-24,2009.

36) Didion SP. Tacrolimus-induced hypertension: what’s endothelial and

hematopoietic FKBP12 got to do with it? Hypertension. 57:1058-1060, 2011.

37) Didion SP. Antioxidant 1 in hypertension: more than just a copper chaperone. Hypertension. 60:285-287, 2012.

38) Li W, Prakash R, Chawla D, Du W, Didion SP, Filosa JA, Zhang Q, Brann DW,

Lima VV, Tostes RC, Ergul A. Early effects of high fat diet on neurovascular function

and focal ischemic brain injury. Am J Physiol. Regul Integr Comp Physiol. 304:R1001-R1008, 2013.

39) Kinzenbaw DA, Chu Y, Pena Silva RA, Didion, SP, Faraci FM. Interleukin-10

protects against vascular dysfunction with aging. Physiol Rep. 1:e00149, 2013.

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40) Fan F, Sun CW, Maier KG, Williams J, Didion SP, Falck JR, Zhuo J, Roman RJ.

20-hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity

and vasoconstrictor response to angiotensin II in renal arterioles. PloS One. 8:e82482, 2013.

41) Lynch CM, Kinzenbaw D, Chen X, Zhan S, Mezzetti EM, Filosa J, Ergul A,

Faraci FM, Didion SP. Nox2-derived superoxide contributes to cerebral vascular

dysfunction in diet-induced obesity. Stroke. 44:3195-3201, 2013.

42) Gomolak JR, Didion SP. Role of innate immunity in hypertension. Med

Hypotheses. 83:640-643 ,2014.

43) Gomolak JR, Didion SP. Angiotensin II-induced endothelial dysfunction is

temporally linked with increases in interleukin-6 and vascular macrophage

accumulation. Front Physiol. 5:396, doi:10.3389/fphys.2014.00396, 2014.

44) Ali MI, Chen X, Mezzetti EM, Didion SP. Heterozygous endothelial nitric oxide synthase is associated with endothelial dysfunction in diet-induced obesity. Physiol

Reports. 3:e12630, 2015.

45) Didion SP. New insights into mechanisms associated with angiotensin II-induced

vascular hypertrophy and remodeling. Hypertension. 67:501-503, 2016.

46) McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR,

Williams JM. Early development of podocyte injury independent of hyperglycemia and

elevations in arterial pressure in non-diabetic obese Dahl SS leptin receptor mutant

rats. Am J Physiol Renal Physiol. 311:F793-F804, 2016.

47) Altara R, Didion SP, Booz GW. Conflicting mechanisms of AT2 receptor

cardioprotection revealed. Cardiovasc. Res. 112:426-428, 2016. 48) Altara R, Harmancey R, Didion SP, Booz GW, Zouein FA. Cardiac STAT3

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deficiency impairs contractility and metabolic homeostasis. Front Pharmacol. 7:436,

2016. 49) Ge Y, Fan F, Didion SP, Roman RJ. Impaired myogenic response of the afferent

arteriole contributes to the increased susceptibility to renal disease in Milan

normotensive rats. Physiol Rep. 5:e13089, 2017. 50) Didion SP. Heterozygous eNOS deficient mice as a model to examine the effects of eNOS haploinsufficiency on the cerebral circulation. J Neurol Neuromed.

2:6-9, 2017. 51) Didion SP. A novel genetic model to explore the Brenner hypothesis: Linking nephron endowment and number with hypertension. Submitted. 52) Didion SP. Heterozygous eNOS deficiency is associated with endothelial

function with age and is sex dependent. Submitted.

53) Wang X, Garrett MR, Didion SP. Direct correlation between blood pressure and

nephron endowment in a genetic mouse model of hypertension. In Preparation.

54) Didion SP. Angiotensin II contributes to both hypertension and endothelial

dysfunction in BPH2 hypertensive mice. In Preparation.

55) Didion SP. Lipopolysaccharide signaling promotes oxidative stress and

endothelial dysfunction in the vascular wall. In Preparation.

Abstracts (*=Peer-reviewed)

1) Didion SP, Morrow RJ, Stratton DB. Contractility changes induced by

endothelial disruption: Mediation by receptor-operated calcium channels. FASEB J.

8:A612, 1994.

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2) Didion SP, Zucker IH, Mayhan WG. Effect of chronic myocardial infarction on

in vivo reactivity of skeletal muscle arterioles. FASEB J. 10:A56, 1996.

3) Mayhan WG, Didion SP. Effect of glutamate on the cerebral microcirculation. FASEB J. 10:A31, 1996.

4) Didion SP, Mayhan WG. Enhanced vasoconstrictor responses of skeletal

muscle arterioles during heart failure: role of impaired synthesis/release of nitric oxide.

Microcirculation. 4:170, 1997.

5) Didion SP, Mayhan WG. Impaired endothelium-dependent response of skeletal muscle arterioles during chronic heart failure: role of oxygen radicals. FASEB

J. 11:A44, 1997.

6) Didion SP, Ishii N, Mayhan WG, Carmines PK. Attenuated nitric oxide

synthase and superoxide dismutase activities during experimental heart failure. FASEB J. 12:A380, 1998.

7) Didion SP, Sigmund CD, Faraci FM. Responses of thoracic aorta in

hypertensive mice expressing the human renin and human angiotensinogen genes.

FASEB J. 13:A512, 1999.

8) Didion SP, Faraci FM. Evidence for an NADH/NADPH oxidase in cerebral blood vessels. FASEB J. 14:A151, 2000.

9) Didion SP, Heistad DD, Faraci FM. Role of soluble guanylate cyclase and

effects of atherosclerosis on responses of cerebral arteries to nitric oxide. FASEB J.

14:A427, 2000.

10) Didion SP, Weintraub NL, Faraci FM. Mechanisms of arachidonic acid-induced relaxation in murine blood vessels. FASEB J. 14:A574, 2000.

11) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Variability of endothelial

function and blood pressure in six inbred mouse strains. FASEB J. 15:A480, 2001.

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12) Didion SP, Faraci FM. Role of endogenous CuZn-superoxide dismutase

(SOD) in the cerebral circulation. FASEB J. 15:A126, 2001.

13) Didion SP, Faraci FM. Effects of NADH on cerebral blood vessels. FASEB J. 15:A127, 2001.

14) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Severely impaired aortic

response to acetylcholine in 129/J inbred mouse strain. Hypertension. 33:134, 2001. *

15) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Heritability of impaired aortic

endothelial function in 129P3/J mice. FASEB J. 16:A880, 2002.

16) Didion SP, Faraci FM. Overexpression of CuZnSOD protects against

ceramide-induced endothelial dysfunction. FASEB J. 16:A1136, 2002.

17) Didion SP, Ryan MJ, Sigmund CD, Faraci FM. Increased superoxide and

vascular dysfunction in CuZnSOD-deficient mice. Hypertension. 40:392, 2002. *

18) Didion SP, Ryan MJ, Faraci FM, Sigmund CD. Activation of PPARg reduces

blood pressure and improves vascular function in hypertensive transgenic mice. J

Hypertension. 20(Suppl 4):S14, 2002.

19) Ryan MJ, Didion SP, Faraci FM, Sigmund CD. Rosiglitazone decreases blood

pressure and improves vascular function in transgenic mice containing human renin and human angiotensinogen. Hypertension. 40:431, 2002. *

20) Didion SP, Didion LA, Fegan PE, Faraci FM Impaired endothelium-dependent

responses in cerebral arterioles of CuZnSOD-deficient mice. Stroke. 34:251, 2003. *

21) Didion SP and Faraci FM. Angiotensin II produces superoxide-mediated

impairment of endothelial function in cerebral arterioles. Stroke. 34:272, 2003.*

22) Baumbach GL, Didion SP, Faraci FM. Deficiency of copper-zinc superoxide

dismutase promotes cerebral vascular hypertrophy. FASEB J. 17:A63, 2003.

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23) Didion SP, Ryan MJ, Sigmund CD, Faraci FM. Enhanced blood pressure

response to angiotensin II in CuZnSOD-deficient mice. FASEB J. 17:A857, 2003.

24) Didion SP, Ryan MJ, Sigmund CD, Faraci FM. PPARg activation improves endothelial function in type II diabetes. FASEB J. 17:A857, 2003.

25) Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Didion SP. Cerebral vascular

effects of angiotensin II: role of gender, rho kinase and AT1a receptors. FASEB J.

18:A1007, 2004.

26) Didion SP and Faraci FM. Vascular dysfunction in TallyHo mice: a new genetic model of type II diabetes. FASEB J. 18:A276, 2004.

27) Faraci FM, Kinzenbaw D, Didion SP. Overexpression of CuZn-SOD prevents

lipopolysaccharide-induced endothelial dysfunction. FASEB J. 18:A1319, 2004.

28) Didion SP, Lynch CM, Faraci FM. Impaired endothelium-dependent responses and enhanced function of rho-kinase in cerebral arterioles in type II diabetic

mice. FASEB J. 18:A1007, 2004.

29) Didion SP, Kinzenbaw DA, Faraci FM. Genetically-altered mice reveal a

critical role for CuZnSOD in preventing angiotensin II-induced endothelial dysfunction.

Hypertension. 44:508, 2004. *

30) Didion SP, Modrick ML, Sigmund CD, Faraci FM. Superoxide-mediated

dysfunction of cerebral arteries in transgenic mice expressing human renin and

human angiotensinogen. FASEB J. 19:A1253, 2005.

31) Brown KA, Didion SP, Andresen JJ, Faraci FM. Mn-SOD deficient mice

exhibit increased oxidative stress and vascular dysfunction with aging. FASEB J. 19:A201,2005.

32) Faraci FM, Modrick ML, Lynch C, Dayal S, Lentz SR, Didion SP. Role of

glutathione peroxidase and hydrogen peroxide in the cerebral circulation: Insight from

GPx-1 transgenic mice. Stroke. 37:686, 2006. *

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33) Didion SP, Lynch CM, Faraci FM. Endothelial dysfunction in cerebral

arterioles in a model of diet-induced obesity and type II diabetes: Role of superoxide

and NAD(P)H oxidase. FASEB J. 20:A295, 2006.

34) Didion SP, Kinzenbaw DA, Schrader LI, Faraci FM. Heterozygous Cu,Zn-

superoxide dismutase deficiency reveals a vascular phenotype with aging. FASEB J.

20:A1452-A1453, 2006.

35) Brown KA, Didion SP, Andresen JJ, Faraci FM. Effect of aging, MnSOD

deficiency and genetic background on endothelial function: evidence for haploinsufficiency. FASEB J. 2006.

36) Chrissobolis S, Didion SP, Faraci FM. Angiotensin (Ang II)-induced oxidative

stress and endothelial dysfunction in the cerebral circulation. FASEB J 20:LB15, 2006.

37) Didion SP, Kinzenbaw DA, Faraci FM. Essential role of interleukin-6 in angiotensin-II-induced endothelial dysfunction. Vascular Pharmacology. 45:e6, 2006.

38) Didion SP. Heterozygous eNOS-deficiency produces oxidative stress and

endothelial dysfunction in a model of diet-induced obesity and type II diabetes.

Hypertension. 48:e35, 2006. *

39) Chrissobolis S, Didion SP, Faraci FM. Protective role of manganese superoxide dismutase against angiotensin II-induced, Nox2-dependent, cerebral

endothelial dysfunction. FASEB J. 21:A1262,2007.

40) Faraci FM, Modrick ML, Lynch C, Dayal S, Lentz SR, Didion SP. Genetic

evidence that cerebrovascular responses to arachidonic acid are mediated by

hydrogen peroxide produced by SOD-1. FASEB J. 21:A1384;2007.

41) Didion SP, Schrader LI, Kinzenbaw DA, Faraci FM. Interleukin-6-deficiency

protects against both acute and chronic angiotensin II-induced endothelial

dysfunction. FASEB J. 21:A590,2007.

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42) Schrader LI, Kinzenbaw DA, Faraci FM, Didion SP. MnSOD

haploinsufficiency promotes oxidative stress and endothelial dysfunction in response

to a high-fat diet. Hypertension. 50:e92,2007. *

43) Chrissobolis S, Didion SP, Kinzenbaw DA, Schrader LI, Dayal S, Lentz SR,

Faraci FM. Glutathione peroxidase-1 protects against angiotensin II-induced

endothelial dysfunction. Hypertension. 50:e103,2007. *

44) Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and

angiotensin II in cerebral vascular dysfunction with aging. FASEB J. 2008 22:1151.21

45) Beyer AM, Guo DF, Didion SP, Sheffield VC, Rahmouni K. Bardet-diedel

syndrome genes are involved in the control of vascular function. Hypertension.

53:e37,2008. *

46) Didion SP, Kinzenbaw DA, Faraci FM. Interleukin-10 protects against vascular dysfunction with aging. FASEB J. 23:805.15,2009.

47) Didion SP. Heterozygous endothelial nitric oxide synthase deficiency reveals

a vascular phenotype with aging that is influenced by gender. Hypertension.

54:e42,2009. *

48) Didion SP. Heterogeneity in constrictor responses among selected inbred mouse strains: influence of rho-kinase. FASEB J. 24:986.13; 2010.

49) Didion SP, Chen X, Mezzetti EM, Ali MI. Interleukin-6 contributes to

endothelial dysfunction in the cerebral circulation in aging. FASEB J.

25:1024.26,2011.

50) Didion SP, Sarmiento JA, Mezzetti EM. Mammalian target of rapamycin (mTOR) inhibition attenuates angiotensin II-induced hypertension and endothelial

dysfunction. Hypertension. 60:A427;2012 *

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51) Palvia V, Pyle C, Mezzetti EM, Chen X, Didion SP. Toll-like receptor 4

contributes to hypertension and endothelial dysfunction produced by angiotensin II.

FASEB J. 25:1024.26,2012

52) Gomolak JR, Faulkner J, Didion SP. Temporal effects of chronic angiotensin

II infusion on blood pressure and vascular function. FASEB J. 27:654.22,2013.

53) Faulkner J, Gomolak JR, Garrett MR, Didion SP. Differential gene expression

profiles produced by a high fat diet in white and brown adipose. FASEB J.

27:738.3,2013.

54) Gomolak JR, Faulkner J, Didion SP. Myloid differentiation factor 88 (MYD88)

does not contribute to hypertension or endothelial dysfunction produced by

angiotensin II. FASEB J. 27:1131.15,2013.

55) Faulkner J, Gomolak JR, Didion SP. Interleukin-10 deficiency limits the development of obesity and insulin resistance produced by a high fat diet. FASEB J.

27:1183.6,2013.

56) Didion SP. Nox2 deficiency limits the development of insulin resistance

produced by a high-fat diet. FASEB J. 27:1192.21,2013.

57) Faulkner JF, Hall JE, Garrett MR, Didion SP. Upregulation of GPR50 in a white adipose depot of diet-induced obese mice requires intact leptin signaling. FASEB J.

28:711.11,2014.

58) Didion SP, Mezzetti EM, Garrett MR. Effect of a high salt diet on endothelial

function and blood pressure in a genetic model of hypertension. J Hypertens.

59) Didion SP. Unholy fire: Discovering Michael Servetus’ contribution to pulmonary physiology through modern historical fiction. FASEB J. 29:1028.1, 2015.

60) Didion SP. Role of increased Serine1176 phosphorylation in maintaining

normal endothelial responses in male and female heterozygous endothelial nitric

oxide synthase (NOS)-deficient mice. FASEB J. 29:1047.6, 2015.

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61) Didion SP, Sims JD, Baldwin ZK. Myeloid differentiation factor-88 deficiency

protects against lipopolysaccharide-induced endothelial dysfunction. FASEB J.

29:625.3, 2015.

62) Didion SP. Interleukin-6 produces oxidative stress and endothelial dysfunction in

the absence of a single endothelial nitric oxide synthase gene. FASEB J. 29:971.10,

2015.

63) Didion SP. Deficiency of vascular TLR4 protects against lipopolysaccharide-

induced endothelial dysfunction and NADPH-oxidase-derived superoxide. FASEB J. 30:1260.10, 2016.

64) Didion SP. Nitric oxide and soluble guanylyl cyclase mediate endothelial

responses in aged female endothelial nitric oxide synthase (eNOS)-deficient mice.

FASEB J. 30:738.1, 2016.

65) Wang X, Garrett MR, Didion SP. Direct correlation between blood pressure

and nephron endowment in a genetic mouse model of hypertension. Hypertension.

68:A052, 2016.

Book Chapters: Didion SP, Chrissobolis S, Faraci FM. Oxidative stress in hypertension. In Oxidative

Stress in Aging. Edited by Miwa S, Beckman KB, and Muller FL. Springer 2008.

Theses: Didion SP. “The role of the endothelium on calcium mobilization in rat aortic smooth

muscle in response to phenylephrine, serotonin, and endothelin-1.” In partial

fulfillment for the MA degree.

Didion SP. “The effect of chronic heart failure on responses of skeletal muscle

arterioles.” In partial fulfillment for the PhD degree.

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FELLOWSHIP AND FEDERAL GRANT SUPPORT

Completed:

1994 Pre-doctoral Fellowship, “Heart Failure and the Microcirculation”,

American Heart Association, Heartland Affiliate (940491S), Salary

Support Only.

1995 Pre-doctoral Fellowship, “Endothelial Dysfunction of the Microcirculation

During Heart Failure”, American Heart Association, Heartland Affiliate

(954027S), Salary Support Only.

1996 Pre-doctoral Fellowship, “Neuropeptides and the Microcirculation during

Heart Failure”, American Heart Association, Heartland Affiliate

(9604027S), Salary Support Only.

1999-2001 Principal Investigator, “Vascular Responses in Transgenic Hypertensive Mice”, National Institutes of Health, Individual National Research Service

Award (HL-10237), Salary Support Only.

2002 Principal Investigator, University of Iowa Diabetes & Endocrinology

Center Pilot and Feasibility Grant, National Institutes of Health (DK-25295), $20,000.

2002-2005 Principal Investigator, “Role of PPARg in Vascular Function During

Diabetes Mellitus”, American Heart Association, National Scientist

Development Award (0230327N), $260,000.

2005-2008 Principal Investigator, “Cerebral Vascular Dysfunction in Response to a

High-Fat Diet”, American Heart Association, Heartland Affiliate Grant-In-

Aid (0565486Z). $143,000.

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Sean P. Didion, PhD, FAHA

2006-2011 Co-Investigator, Project 1: “Vascular Protection During Hypertension:

Inflammatory Mechanisms.” NIH/NHLBI Program Project Grant (HL-

62984): “Oxidative Mechanisms in Vascular Disease”; Principal Investigator, Donald D. Heistad.

2010-2012 Principal Investigator, American Heart Association Southeast Affiliate,

Grant-In-Aid. “Mechanisms of Endothelial Dysfunction in Obesity.”

*Awarded but returned due to scientific overlap with R01-HL089884.

2010-2015 Principal Investigator, “Mechanisms of Vascular Dysfunction in Diet-

Induced Obesity” NIH/NHLBI (R01-HL089884). $250,000/yr direct costs.

Current: NIH/NHLBI (R01-HL107632) – Didion (PI)

“Molecular Mechanisms of Hypertension in the Microcirculation”

Period: 5/2011-5/2017 on NCE

Role: Principal Investigator $250,000/yr direct costs.

National Institutes of Health/NIBIB (R01-EB020006) – Janorkar (PI)

“3D Spheroid Model of Adipose Pathophysiology”

Period: 9/2016-8/2021 Role: Co-Investigator

Direct Costs: $250,000/yr

Pending: NIH/NHLBI (R01-HL138106)- Didion (PI)

“Cardiovascular Inflammation and Circadian Disruption”

Period: 05/01/17-04/30/2022

Role: Principal Investigator (25% effort)

$250,000/yr direct costs

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Sean P. Didion, PhD, FAHA

NIH/NHLBI (R01-HL137883)- Booz (PI)

“Transition from Endothelial Inflammation to Diastolic Dysfunction in HFpEF”

Period: 05/01/17-04/30/2022

Role: Co-Investigator (5% effort)

$250,000/yr direct costs

NIH/NHLBI (R01-HL137789)- Pabbidi (PI)

“Mechanisms Underlying Cerebrovascular Function: Role of

Gender and Age”

Period: 05/01/17-04/30/2022 Role: Co-Investigator (5% effort)

$250,000/yr direct costs

NIH/NHLBI (R01-HL13726)- Garrett (PI)

“Genetic Targets of Hypertension End Organ Damage” Period: 05/01/17-04/30/2022

Role: Co-Investigator (5% effort)

$250,000/yr direct costs

June 2017