DepressionTRICYCLIC (TCA) AND SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI)

Ali GomezWri 116Fall 2013

“I never considered that an underlying condition was hampering my ability to

handle the stress. I thought, this is just how life is. ”

What is Depression? Disorder Interferes with daily activity Causes pain for both the person with it

as well as people around them Interferes with person's ability to work,

sleep, study, eat, and enjoy once-pleasurable activities

Mood changes

Treatment: DRUG THERAPY

Many different forms Most common ones:

Tricyclic Antidepressant (TCA)

Selective Serotonin Reuptake Inhibitor (SSRI)

Both given in pill form Effects the nerves Dosage depends on age and level diagnosed

Tricyclic Antidepressant Earliest prescribed Main goal: make chemical changes in the brain = slow

reuptake Reuptake: when a shock leaves the brain and is absorbed

back into the nerve cell in brain Shock = neurotransmitters The chemicals are usually serotonin and norepinephrine Side effects:

weight gain, dry mouth, constipation, drowsiness, and dizziness.

1. Shock occurs (shout: dinner)

2. Serotonin are realeased (stand up)

3. Serotonin goes through the gap (walk to table)

4. Enters receptors = (sit down and talk about day)

5. Reuptake slow(go back to living room)1. Black certain

recepters = side effects

Selective Serotonin Reuptake Inhibitor (SSRI)

Most prescribed anti- depressants

ease symptoms of moderate to severe depression

are safer

cause fewer side effects than other types of antidepressants

Side effects: Nausea, Nervousness, agitation or restlessness, Dizziness

Reduced sexual desire or difficulty reaching orgasm or inability to maintain an erection (erectile dysfunction)

Drowsiness, Insomnia, Weight gain or loss, Headache, Dry mouth, Vomiting, Diarrhea

http://www.youtube.com/watch?v=sc-4zhqViQ4http://www.youtube.com/watch?v=sc-4zhqViQ4

Study: Efficacy and Tolerability of Tricyclic Antidepressants and SSRIs Compared With Placebo for Treatment of Depression in Primary Care

Bruce Arroll, MBChB, PhD, Department of General Practice and Primary Health Care, University of Auckland, Private Bag 92019, Auckland, NZ

Methods: Adults

TCA, SSRI, and Placebo (control treatment)

Primary care patients

Low dose (75mg and 100 mg)

10 studies

2-6 weeks

Results 3 SSRI and placebo

2 TCA and Placebo

56% - 70% responded well to active treatment

42% - 47% responded to Placebo

Relative Risk for withdrawal 2.35 for TCA

Non for SSRI

Relative Risk (less likely to occur an experimental group than in controld group) 1.26 for TCA

1.37 for SSRI

Conclusion

Both TCA and SSRI are effective

Low dose are effective in primary care

TCA and SSRI are more effective than placebo