Department of Pathology ANNUAL REPORT - University of Western

Department of Pathology

2011ANNUAL REPORT

2 | Department of Pathology Annual Report 2011

TAB

LE OF C

ON

TENTS

04-05 Section 1 - Vision/Mission/Values

06-07 Section 2 - Message from the Chair/Chief

08-10 Section 3 - Organizational Charts

08 • 3.A – UWO Department of Pathology

09 • 3.B – PALM Program

10 • 3.C – PALM Administrative Support

11-15 Section 4 - Staff

00 • 4.A – Faculty Quick Facts (at September 1, 2011)

12 ◦4.A1–PrimaryAppointed

13 ◦4.A2–CrossAppointed

13 ◦4.A3–SWOMEN

13 ◦4.A4–LimitedDuties

14 • 4.B – UWO Pathology Staff

15 • 4.C – In Memoriam

16-20 Section 5 - Pathology & Laboratory Medicine Program

16 • 5.A – Report from Sue Volbrecht, Administrative Director (Acting)

19 • 5.B – Report from Debbie Gaskin, Pathology Labs Manager

21-31 Section 6 - Division Head & Medical Leader Reports

21 • 6.A – Anatomical Pathology

21 ◦6.A1–SurgicalPathology,Dr.C.M.McLachlin

23 ◦6.A2–ForensicPathology,Dr.M.Shkrum

24 ◦6.A3–Cytology,Dr.M.Joseph

26 ◦6.A4–MolecularPathology,Dr.J.Knoll

28 • 6.B – Oral Pathology, Dr. T. Daley

29 • 6.C – Medical Microbiology, Dr. R. Lannigan

31 • 6.D – Neuropathology, Dr. L.C. Ang

Pages

Department of Pathology Annual Report 2011 | 3

TAB

LE O

F C

ON

TEN

TS

33-62 Section 7 - Education Programs: Report from the Director

of Education, Dr. David Driman

35 • 7.A – Postgraduate Programs – Program Director Reports

36 ◦7.A1–Anatomical&GeneralPathologyProgram,Dr.J.Shepherd

38 ◦7.A2–NeuropathologyProgram,Dr.L.C.Ang

40 ◦7.A3–MedicalMicrobiologyProgram,Dr.R.Lannigan

42 ◦7.A4–Trainees

44 • 7.B – Graduate Education Programs

44 ◦7.B1–ResearchBasedGraduateProgram,Dr.C.Chakraborty

48 ◦7.B2–Course&PracticumBasedProgram

(P.A.Program),Dr.N.Chan

49 ◦7.B3–StudentPublications&Presentations

49 ◦7.B4–StudentAwards

49 ◦7.B5–AlumniUpdates

50 ◦7.B6–CourseOfferings

54 • 7.C – Undergraduate Education Programs

54 ◦7.C1–Pathology,Dr.C.Gibson

57 ◦7.C2–Pathology–Medicine,Dr.M.Joseph

59 ◦7.C3–Pathology–Dentistry,Dr.M.Darling

61 • 7.D – Professional & Education Development

Chair Report, Dr. K. Kwan

62 • 7.E – Expanding our Educational Reach in the region

and Around the world

63-90 Section 8 - Research

63 • 8.A – Message from the Director of Research, Dr. J. Bend

70 • 8.B – Publications, Book Chapters and Abstracts

78 • 8.C – Invited Lectures

85 • 8.D – Research Funding

91-94 Section 9 - Awards and Honours


SECTIO

N 1 – VISIO

N / M

ISSION

/ VALU

ES

Section 1 – Our Vision, Mission and Core Values

TheDepartmentofPathologyfullysupportsthemissionandvaluesoftheSchulichSchoolofMedicine&DentistryofTheUniversityofWesternOntario,LondonHealthSciencesCentreandSt.Joseph’sHealthCareLondon.

Vision

Providestate-of-the-artdiagnosticpathologyserviceswhileachievingexcellenceinpathologyresearchandeducation.

Mission

MembersoftheDepartmentofPathologystrivetoprovideaqualityworkenvironmentthatfostersunity,respectfordiversity,teamworkandprofessionalgrowth.Wearecommittedtoserveour:

Patients,byprovidingefficient,comprehensiveandhighqualitydiagnosticservicesforoptimalpatientoutcomeandhealth.Wearecommittedtostrategiesthatresultincontinuousimprovementofthequalityofourservices.

Students,byprovidingthebeststudentexperiencethroughoutstandingeducationalprogramsforundergraduate,graduateandpostgraduatestudents,andotherhealthcareprofessionalswithinaclinicalandresearchintensiveenvironment.Weintegratecontinuingmedicaleducationprogramsintothedepartmentalactivities.

ScientificResearchCommunityandHealthCarePartners,bysharingexpertise,fosteringinterdisciplinarycollaboration,andprovidingexemplaryeducationalandscientificresources.Weareastrongclinicalandbasicsciencedepartmentandourresearchendeavorsincludebasicscience,clinicalandtranslationalresearch.


SEC

TIO

N 1

– V

ISIO

N /

MIS

SIO

N /

VALU

ES

Weprovideresearchleadershipbyidentifyingourstrongresearchstrengthsandenhancingresearchproductivitywithselectiveallocationofresources.WeguideandcollaboratewithourregionalpartnerstoimprovethediagnosticpathologyservicesthroughoutSouthwesternOntario.

Society,byactivelyapplyingtheartandscienceofpathologyineducatingthecommunityinmattersofhealthanddisease.OurCoreValues

Team Work

Webelieveinateam-basedproblemidentificationandproblemsolvingmethodology.Webelieveininterdisciplinarynetworking.

Innovation

Weareflexibleandadaptableinordertomeetthechangingneedsofsociety.Westronglybelieveincontinuousqualityimprovementtoenhanceclinicalperformanceoutcomes.

Leadership

Westronglyencouragememberstotakeleadershiprolesineducation,researchandmanagement.Wesupporttheleaderswhoguideourmission.

“We must become the change we want to see”

Mahatma Gandhi

(1869-1948)


SECTIO

N 2 – M

ESSAG

E FRO

M TH

E CH

AIR

/ CH

IEF

Section 2 – Message from the Chair/Chief

IamprivilegedtopresenttheAnnualReportfortheDepartmentofPathologyattheUniversityofWesternOntario.Wehad

aremarkableyearinwhichtherewasachangeintheleadershipofourdepartment.Dr.BerthaGarcia,whosuccessfullyled

ourdepartmentforthelast12years,steppeddownasofJuly2011todevotefulltimetoherroleasVice-Dean,Education

atSchulich.Dr.GarciawasthedepartmentChairthroughchallengingtimesandherleadershipresultedinsignificant

growthofthePathologyDepartment.Hersignificantcontributionshaveprovidedastrongfoundationforourdepartmentas

wemoveforward.

Afewyearsagowesetstrategicgoalsinalongtermplanandwecontinuetofinetuneandfollowinthisdirection.AsI

startmyjourneyleadingthisgreatdepartment,Ihavenotedthatoverthelastyearourfaculty,staff,studentsandtrainees

haveworkedextremelyhardtomakesurethatwesuccessfullyachieveourgoalsinclinicalandacademicactivities.

Ourclinicalworkloadcontinuestobechallenginginvolumeandcomplexity.WeareintheprocessofintegratingthelaboratoryservicesoftheMiddlesex

HealthAlliancewiththoseofourdepartment.Recently,werestructuredseveralofouradministrativefunctionstoimprovetheefficiencyofthepathologyand

clinicallaboratories.Dr.C.M.McLachlinhasbeenappointedasMedicalDirectorofAnatomicalPathologyandDr.V.PrabhakaranasMedicalDirectorof

ClinicalLaboratories.Dr.McLachlinwilloverseeSurgicalPathology,Cytology,AutopsyPathologyandMolecularPathologyactivities.Dr.Prabhakaranwill


SEC

TIO

N 2

– M

ESSA

GE

FRO

M T

HE

CH

AIR

/ C

HIE

F

overseeImmunologyandBiochemistry,Microbiology,TransplantImmunology,PulmonaryFunctionLaboratoriesandHematologyactivities.Inaddition,Dr.

HelenEttlerhasbeenappointedasMedicalLeaderofSurgicalPathologyandDr.KeithKwanasSectionHeadofGrossandHistopathologylaboratories.

Workinginpartnershipwithotherexistingleaders,thisgreatteamwillmoveforwardtheacademicandclinicalmissionsofPathologyandLaboratory

Medicine.

Intheacademicarena,Dr.JackBendandDr.DavidDrimanhaveacceptedthepositionsofResearchDirectorandEducationDirector,respectively.Dr.

ChandanChakrabortyhasacceptedthepositionofChair,Research-basedGraduateProgram,andDr.NancyChanwillChairtheGraduateEducation

CommitteeforthePathologistAssistantProgram.BothourGraduateprogramsandResidencyprogramshavecontinuedtodemonstratestellar

performance.Departmentmemberscontinuetocontributealargevolumeofteachingtovariousundergraduate,graduateandpost-graduateprograms.

ThisyeartheDepartmentofPathologyalsobecamethehomefortheMotorVehicleSafety(MOVES)ResearchTeam.Thisuniquemultidisciplinaryteam

undertheleadershipofDr.MikeShkrumwillcarryoutcuttingedgeresearchinthisfield.Departmentalmembersauthoredasignificantnumberofresearch

publications,book-chaptersandabstracts.Theacademiccontributionsofdepartmentalfacultyhavebeenrecognizedwithvariousnationalandinternational

awardsincluding,appointmentsasFellowoftheCanadianAcademyofHealthSciences(Dr.JackBend)andFellowoftheRoyalSocietyofMedicine(Dr.

DavidWhite).Weareveryexcitedabouttheopportunityforgrowthinoureducation,practiceandresearchactivities.IntheNewYear,wewillberecruitinga

BasicScientist,aClinician-ScientistandanAnatomicPathologist.

Ibelievethatweareinanexcitingtime.OurPathologyDepartmentsharesthecommonvisionoftheUniversityofWesternOntario,theSchulichSchoolof

MedicineandDentistryandtheLondonHealthSciencesCentre.Ourdedicatedgroupofpathologists,educatorsandscientists,withtheircommitmentto

patientcare,educationandresearch,arereadytocontinueonthisexcitingjourneyandIamsurethatwewillmakeithappen.

OnasadnotethedepartmentwasshockedwhenourcolleagueandfriendMs.KrisMilnepassedaway.Kriswasanoutstandingmediaspecialistand

supportedouracademicactivitiesoverseveralyears.WewillallmissKrisverymuch.

WithbestwishesfortheNewYear,

Sincerely,

SubrataChakrabarti


SECTIO

N 3 – O

RG

AN

IZATION

AL C

HA

RTS

Section 3 – Organizational Charts

Department of Pathology Schulich School of Medicine & Dentistry

Organizational Chart

Please see Section 5 for Organizational Chart for Pathology & Lab Medicine at LHSC

Chair

Dr. Subrata Chakrabarti

Executive Committee

Director of Research

Dr. Jack Bend

Executive Committee

Director of Education

Dr. David Driman

Residency Training Programs

Anatomical Pathology Residency Program

Dr. Jessica Shepherd Program Director

Neuropathology Residency Program

Dr. Lee Cyn Ang

Program Director

Medical Microbiology Residency Program

Dr. Rob Lannigan

Program Director

Graduate Programs

Research-Based Graduate Programs

Dr. Chandan Chakraborty Graduate Chair

Course & Practicum Based Graduate Program (PA)

Dr. Nancy Chan

Program Chair

Undergraduate Programs

Pathology Undergraduate Medicine

Dr. Mariamma Joseph

Chair

Pathology Undergraduate

BMSc, BSN, BHSc, BSc

Dr. Candace Gibson

Chair

Pathology Undergraduate Dentistry

Dr. Mark Darling

Chair

Executive Committee

Laboratory Directors

TBA (see PALM org chart)

3.A – UWO Department of Pathology Organizational Chart


SEC

TIO

N 3

– O

RG

AN

IZAT

ION

AL

CH

AR

TS3.B – PALM Program Organizational Chart

Revised:October3,2011

Core Laboratory - SJHC/UH/VHDr. Vipin Bhayana / Dr. Ian Chin-Yee

Cathie McIntyreSpecimen Receiving Area - SJHC/SSH/UH/VH - Jennifer Bell

Organizational Chart

Pathology & Laboratory Medicine Program

TransplantImmunologyMedicalLeaderDr. Edward Ball

ManagerDebbie Gaskin

Transplant ImmunologyDr. Edward BallTBA (interim)

(A)AdministrativeDirectorSue Vollbrecht

ProgramLeaderDr. Subrata Chakrabarti

SurgicalPathologyMedicalLeader

Dr. Meg McLachlin


ImmunohistochemistryDr. Bret WehrliDonna Murphy

HistologyDr. Meg McLachlin

Donna Murphy

Grossing/SRADr. Meg McLachlin

Michael Graves

CytologyMedicalLeaderDr. Mariamma

Joseph


MicrobiologyMedicalLeader

Dr. Robert Lannigan

ManagerViki Massey

LHSCPulmonaryFunction

MedicalLeaderDr. Sanjay Mehta

(A)ManagerMichael Keeney

CytologyDr. Mariamma Joseph

Donna Murphy

Molecular PathologyDr. Chris Howlett

TBA

Reese LaboratoryDr. Mariamma Joseph

Donna Murphy

CytogeneticsDr. Jie Xu

TBA

Molecular BiologyDr. Peter Ainsworth

TBA

Biochemical GeneticsDr. Tony Rupar

TBA

HematologyMedicalLeader

Dr. Ian Chin-Yee


AutopsyServices

MedicalLeaderDr. Michael Shkrum


MolecularPathologyMedicalLeaderDr. Joan Knoll


Pulmonary Function -UH/SSH/VH

Dr. Sanjay MehtaSue Vollbrecht

Special HematologyDr. Ian Chin-YeeMichael Keeney

HemostasisDr. Joy MangelMichael Keeney

Clinical ImmunologyDr. Liju Yang

Rich Bak (interim)

Immunosuppresive DrugMonitoring

Dr. Norman SmithRich Bak

Immunology and BiochemistryMedicalLeader

Dr. Victor Prabhakaran


Toxicology and SpecialChemistry

Dr. Norman SmithRich Bak

ThrombosisDr. Michael Kovacs

Michael Keeney

A Joint Venture of London Health Scie nces Centreand

St. Joseph's Health Care London

EndocrinologyDr. Alan Dennis

Rich Bak

Electron MicroscopyDr. Madeleine Moussa

Donna Murphy

VirologyDr. Robert Lannigan

Sue Milburn

MicrobiologyDr. Zaf Hussain

Sue Milburn

Infection ControlDr. Michael John

(reports through Medical Education& Medical Affairs)

AutopsyDr. Michael Shkrum

Michael Graves

Regional Forensic UnitDr. Michael Shkrum

Michael Graves

Point-of-Care TestingDr. Victor Prabhakaran

Wendy Stratton

Maternal Serum ScreenDr. Alan Dennis

Rich Bak

Flow CytometryDr. Ian Chin-Yee

Dr. Kamilia RizkallaMichael Keeney

Transfusion Medicine -SJHC/UH/VH

Dr. Ian Chin-YeeJeff Kinney

Trace Elements LabDr. Liju Yang

Rich Bak


SECTIO

N 3 – O

RG

AN

IZATION

AL C

HA

RTS

3.C – PALM Administrative Staff Organizational Chart


SEC

TIO

N 4

– S

TAFF

FTClinicalAcademics:30

FTBasicScientists:7

Emeriti:11

CrossAppointees:13

InstituteScientists:6

Adjunct/MD:14

Limited-DutyAppointees: 6

UWOStaff(FT&PT): 7

PathologyResidents:14

PathologyGraduateStudents:36

PostdoctoralFellowsandAssociates,

andVisitingScientists:4

Undergraduate Medicine

(Meds I, Meds II, Meds IV):

MedsI–133UWO/38Windsor

MedsII-129UWO/30Windsor

MedsIV-(PrimaryCarePathology–120)

(ForensicMedicine–110)

Clincal Clerkship / Visiting Electives /

Meds / Observerships:

MedsIIIElectives–4

MedsIVElectives–3

VisitingElectives–6

MedsIObservership–1

Other Electives:

InternationalObservership–1

Section 4 – Staff

4.A – Department of Pathology Quick Facts (At September 1, 2011)


SECTIO

N 4 – STA

FF

Postgraduate Medicine (Resident Electives):

Neuropathology– 7

GeneralPathology– 8

AnatomicalPathology-33

Undergraduate Dentistry:

Dents5304(Section001–56;Section003–13)

Dents5162–56

Dents5170–56

Dents5235-56

BScN / Nursing:

Path2420a(001UWO)–125

Path2420A(003CTF)–51

Path2420a(600FC)–113

Path2420a(specialAnatomyGradStudents)–5

Biological and Health Sciences:

BMSc Pathology & Toxicology: 14

Path3240a/9240a–154/16

(undergrad/gradstudents)

Path3245b/9245b–100/4

Path4400b/9540b–40/4

Path4500b/9550b–25/5

Professor and Chair

SubrataChakrabarti

Professors

LeeCynAng

JackBend*

TomDaley

DavidDriman

BerthaGarcia

RobHammond

ZafarHussain

MichaelJohn

MariammaJoseph

JoanKnoll

RobLannigan

MegMcLachlin

MadeleineMoussa

DavidRamsay

KamiliaRizkalla

MikeShkrum

Associate Professors

ChrisArmstrong

TedBall**

MarkDarling

HelenEttler

CandaceGibson

JoseGomezLemus

KeithKwan

CarolynMcLean

JessicaShepherd

AlanTuck

TedTweedie

BretWehrli

MicheleWeir

JieXu**

Assistant Professors

ChandanChakraborty

NancyChan

ManalGabril

AaronHaig

ChristopherHowlett

ZiaKhan

JeremyParfitt

ElenaTugaleva

Professors Emeriti

GeorgeCherian

John.V.Frei

JoeGilbert

RobertA.Goyer

ColletteM.Giraudon

M.DariaHaust

JohnKaufmann

MaryEllenKirk

D.IanTurnbull

GeorgeWysocki

In Memoriam

ColinAnderson

* Distinguished University

Professor

** Institute Scientists, primary

appointment in Pathology

4.A1 – Primary Appointment in Pathology


SEC

TIO

N 4

– S

TAFF

Professors

PaulAdams(Medicine)

AnnChambers(Oncology)

RegnaDarnell(Anthropology)

GuidoFiller(Paediatrics)

CarolHerbert(FamilyMedicine)

SteveKarlik(MedicalImaging)

JimKoropatnick(Oncology)

MichaelStrong(CNS)

CharlieTrick(Biology)

JimXuan(Surgery)***

Associate Professors

CindyHutnick(Opthamology)

WeipingMin(Surgery/Lawson)****

HaoWang(Surgery/Lawson)****

Assistant Professors

TishaJoy(Medicine)

TianqingPeng(Medicine/Lawson)****

Zhu-XuZhang(Medicine/Lawson)****

*** Basic Scientists in clinical department

**** Institute Scientists in clinical department

4.A2 – Cross Appointees 4.A4 – Limited Duties Appointees

4.A3 – South West Ontario Medical Education Network (SWOMEN) & Rural RegionClinical Adjunct Professors PeterAinsworth(UWO,Pediatrics)

EdithArany(Medicine)AssistantProfessor

TyrreldeLangley(ACVS)AssistantProfessor

VictorPrabhakaran(UWO,Biochemistry)

DavidWhite,Professor,PostRetirement

XiufenZheng(Surgery)AdjunctResearchProfessor

PatAllevato(WindsorRegionalHospital)

SaadAwad(ChathamKent)

RamGidwani(BluewaterHealth)

OmarHakim(WindsorRegionalHospital)

DongLiu(WoodstockGeneralHospital)

RosemaryLubynski(BluewaterHealth)

MarvenOxley(WindsorRegionalHospital)

BassemMoussa(ChathamKentHealthNetwork)

BrianRudrick(GreyBruce,OwenSound)

P.C.Shah(StrathroyMiddlesexHospital)

SajidShukoor(HotelDieuGrace,Windsor)

DavidShum(WindsorRegionalHospital)

LatifTadross(GuelphRegionalHospital)

AbdelghaniTbakhi(WindsorRegionalHospital)


SECTIO

N 4 – STA

FF

TheUWOstaffteamisadedicatedgroupofskilledindividuals,whoworkinthebackgroundtosupporttheacademicandresearchmissionsofthe

department.Theadministrativeteamisproudoftheworktheydoandtheimportantcontributionsandimpactthatthishasonthedepartmentasawhole.

4.B – UWO Pathology Staff

CherylCampbell(UndergraduateProgramAssistant),TraceyKoning(GraduateProgramAssistant),

SusanStewart(ResidencyProgramAssistant),MairHughes(AdministrativeOfficer),

LindaJackson-Boeters(DepartmentalTechnician),KathilynOnn(MediaSpecialist),

GailHeslinga–onvacation(Receptionist/AdministrativeAssistant).

WewerethrilledthisyearwhenLindaJackson-

BoeterswasawardedtheDean’sAwardof

ExcellenceforStaff.Linda’spositiveoutlook

andcommitmenttoservicemakehera

pleasuretoworkwithandtrulydeservingof

thishonour.CongratulationsLinda!


SEC

TIO

N 4

– S

TAFF

Ourfriendandcolleague,KristineMilnepassedawayonSaturdayApril30,2011athome,

surroundedbytheloveandcareofgreatfriends,hersonNathan,andherbeloveddogRuby.

KrishadalongandverydedicatedcareerwiththeDepartmentofPathologywhichshejoined

in1974asaparttimeLibraryAssistantaftercompletingherAudioVisualTechnologydiploma

atFanshaweCollege.KriscompletedherHonoursB.A.inVisualArtsatWesternwhile

workingfulltime.Shewaspromotedin2000toMediaSpecialist.

Krissupportedthefaculty,clinicians,graduatestudentsandresidentsintheDepartmentof

Pathology,intheproductionanduseofvisualteachingaidsfortheirteachingandresearch.

KriswasalsowellknowntotheSchulichandWesterncommunitiesforrunningalargeformat

printingservice,astheUWOSArepresentativeontheUWOStaffDevelopmentSteeringTeam

andforteachingmediaworkshopsforSchulichFacultyDevelopment.Hersenseofhumour,

positiveoutlookandhercommitmenttoservicemadeKrisapleasuretoworkwith.

4.C – In Memoriam


SECTIO

N 5 – PATH

OLO

GY &

LAB

OR

ATORY M

EDIC

INE PR

OG

RA

M

5.A – Report from Administrative Director (A), Sue Volbrecht

ThePathology&LaboratoryMedicineProgram(PALM),attheLondonHealthSciencesCentreandSt.Joseph’sHealthCareLondon,providesarangeof

routineandspecializedlaboratorytestingandclinicalconsultationtosupportthediagnosisandtreatmentofpatientswithinsouthwesternOntario,aswellas

nationallyandinternationally.

ThefollowingaresomehighlightsfromPALMforthepasttwelvemonths:

Laboratories on the Move

NinespecializedlaboratorieswererelocatedfromvariousLondonhospitalsitestothe10thfloor,Bwingtower,VictoriaHospitalattheendof2010.The

moveswerepartoftheMilestone2Phase2(M2P2)city-widehospitalrestructuringproject.Withthebestviewsinthecity,thisnew27,400sq.ft.space

isoccupiedbytheclinicalimmunology,moleculardiagnostics,molecularpathology,traceelements,toxicology&specialchemistry,microbiology/virology,

cytogenetics,endocrinology,andmaternalserumscreeninglaboratories.Consolidationhasbroughttogethertechnologists,scientists,andlaboratory

medicalstafftoshareideas,equipment,andresources;whichpromotesopportunitiestoimproveprocessusingLEANmethodologyandpromotes

enhancementstopatientcare.

Section 5 – Pathology & Laboratory Medicine Program


SEC

TIO

N 5

– P

ATH

OLO

GY

& L

AB

OR

ATO

RY M

EDIC

INE

PRO

GR

AM

Laboratory Information System

Thetransplantlaboratoryandinformationtechnologyserviceshavebeenworkingdiligentlytobringhumanleukocyteantigen(HLA)testingtotheCerner

clinicalinformationsystem.ThegolivedatewasMarch28,2011.HLAordersarenowavailableforon-lineorderingthroughPowerChartandclinicalstaff

withtheproperaccesspermissionswillbeabletoviewHLAresultsinPowerChart.

Immunohistochemistry Laboratory

TheimmunohistochemistrylaboratoryatUHhasundergonesignificantchangesin2010.ThelabacquiredthreenewDakoAutostainerLink48automated

immunohistochemicalstainersalongwith4PTLinkpretreatmentmodules.TheDakoAutostainerLink48stainersutilizeDako’smostrecentsoftwareand

connectivityoptionstoimproveworkloadmanagementwhilemaintainingoptimalstainingresults.ThePTLinkmodulesallowtheentirepre-treatment

processofdeparaffinization,rehydration,andantigenretrievaltobecombinedintoa3-in-1procedure.

New Voice Recognition System

AtUniversityHospital,avoicerecognitionsystemcalledDragonwasimplementedfor8pathologists’assistantsinthegrossroom.Priortothis

implementation,thepathologistassistantsdictatedgrossdescriptionsforsurgicalspecimensoncassettetapeswhichwerelatertranscribed.Thenew

systemnowdirectlycapturesdictationselectronicallywhichisthenreviewedinstantlybythepathologist’sassistant.Thisinformationiscopiedtothe‘gross

description’sectionoftheelectronicpathologyreport.Computersateachstation

provideimprovedaccesstoapplicationsrequiredbystaffduringthegross

examinationprocess.

Blood Transfusion Medicine Symposium

OnNovember6,2010,thebloodtransfusionlaboratorypresentedtheirannual

symposium.Thisyear’stopicwas“SpecialProductsforSpecialPatients”.The

keynoteaddresswasdeliveredbyDr.WendellRosse,ProfessorEmeritus,

DukeUniversityMedicalCentre.Dr.Rosseisrecognizedthroughouttheworld

forhisworkintransfusionmedicineandinparticularparoxysmalnocturnal

hemoglobinuria(PNH).Therewere100participantsinattendancefrom

throughoutsouthwesternOntario.ThesymposiumwassponsoredbyLLSG,

OrbconandCanadianBloodServices.


SECTIO

N 5 – PATH

OLO

GY &

LAB

OR

ATORY M

EDIC

INE PR

OG

RA

M

Ontario Laboratory Accreditation

Thehospital’slaboratorieswereassessedbyOntarioLaboratoryAccreditation(OLA)June20-24,2011.OLAisapeerreviewassessmentprocesswhich

ensuresthatlaboratoriesmeetexplicitqualitymanagementcriteria,inordertoprovideformalrecognitionthatthelaboratoryiscompetenttocarryout

examinations.AccreditationassessmentvisitsdetermineiflaboratoriesconformtotheOLArequirements,whicharebasedonISOstandards,Canadianand

provincialstatutes,regulationsandstandards,andHealthCanadaGuidelines.Thirteenassessorswereonsitetoevaluateeachof25laboratorysections.In

additionassessorsobservedbloodtransfusionpracticesandprocessesforpointofcare(bedside)testingsuchasglucose,urinalysisandfecaloccultblood.

Thelaboratoriesmet97%oftherequirementsasstatedandfouryearaccreditationcertificateswereissued.


SEC

TIO

N 5

– P

ATH

OLO

GY

& L

AB

OR

ATO

RY M

EDIC

INE

PRO

GR

AM

5.B – Report from Pathology Laboratories Manager, Debbie GaskinThePathologyLaboratoriesatLondonHealthSciencesCentreincludethefollowingfacilitiesunderthedesignatedcoordinators:

Coordinator – Laurie Floyd:

•PathologyClericalSupportGroup

Coordinator – Donna Murphy:

•AnatomicalPathology

•AncillaryPathology

(whichincludesElectronMicroscopy)

•ImmunopathologyandNeuropathology

•Cytology(includingtheReeseLaboratory)

Coordinator – Mike Graves:

•AutopsyServices

•GrossingRoom

•SpecimenReceivingArea

•UHPathologyMLATeam

Coordinator – Russ Wheeler (until Sept 2011):

•BiochemicalGenetics

•Cytogenetics

•MolecularDiagnostics

•MolecularPathology

•TransplantImmunology

Ourfocusisonservice,educationandresearch.Servicechallengesincludemanagingtheincreasesinvolumesandcomplexityofthetestingwhile

incorporatingnewtesting.Wehavebeensuccessfulinsupportingthetechnicalcomponentinthelaboratory.Ineducation,thePathologyLaboratoriesare

activelyinvolvedintheteachingofstudentsintheMedicalLaboratoryTechnologist,andMedicalLaboratoryAssistantprograms.


SECTIO

N 5 – PATH

OLO

GY &

LAB

OR

ATORY M

EDIC

INE PR

OG

RA

M

Section 5c: Pathology Laboratories

Staff Numbers (127)Clerical Support Coordinators /Support

CoordinatorsLab Assistants Pathologist’s

AssistantsResearch

Associates & Assistants

Technologists (including senior

techs)

Scientists

19/1 3/1 10/6 8 3/1 71/3 1

July2010-June2011statistics

Approximate Statistical AveragesHistopathology / Cytology

Autopsy # Coroners Cases

Surgical Cases

Intra-Operative Consultation

Reports

Slide Counts Block Counts Rapid Processing CytologyGyn Non-Gyn FNA

145 443 45097 1455 415,646AllSlidesS/A/

IHC

190,115 30719,004

8464(includes#FNA) 1938

Molecular/GeneticsCytogenetics Molecular Biology Molecular Pathology Biochemical

Initial Handling & Report

Sign Off Genetics Specimens TestsAbnormal

Case Complex

CaseNormal Case

Oncology Case

3903(specimens)

478 304 1810 1917 4649 306 6113

TransplantTests8166

WeareveryproudtoprovidetheonlyaccreditedPathologist’sAssistantsprograminCanada,inwhichtheteachingopportunitieshavebeenfullyembraced

byourtechnicalstaff.

AttheUniversitysite,weamalgamatedthemedicallaboratoryassistantsinthepathologyportfoliotoformtheUHPathologyMLATeam.Thishasallowed

usflexibilitytobetteraddressourgrowingrequests.Wetakeanactiveapproachwithresearchprograms,incollaborationwithbothhospitalandgovernment

fundedsources.Ourlaboratoriessupplytechnicalsupportandexpertisetooutlyingregionalfacilities.


SEC

TIO

N 6

– D

IVIS

ION

HEA

D &

MED

ICA

L LE

AD

ER R

EPO

RTS

TheDepartmentofPathologyisstaffedby27surgicalpathologists,including3neuropathologists.Aswellthereare2oral

pathologiststhatareaffiliatedthroughtheUniversityDepartment.ThedivisionofSurgicalPathologyisleadbyDr.MegMcLachlinwhoalsoactsasthe

DeputyChiefofPathology.AnewpositionnegotiatedaspartofthepackageforournewchairandpartiallyfundedthroughtheMOHLTC/OMAagreementfor

newlaboratorymedicinepositionsisbeingadvertisedinthefallof2011.Thisnewpositionisacombinedclinicalresearchpositionandwillhavesignificant

protectedtimefortheindividualhiredtosetupanindependentresearchprogram.

TheDepartmentofPathologyendeavorstoprovideabalancedapproachtoservice,education,quality,andresearch.Wehavecontinuedtorefineour

subspecialtyapproachforthesurgicalpathologyserviceswithdedicatedteamsofpathologistsprovidingfocusedexpertise.Therehavebeenrecent

increasesinvolumesforsometeams(egGIbiopsieshaveincreasedwithaddedfundingforendoscopyservices)andallteamsaredealingwithincreased

complexityintheirreportingrequirements.ThisisespeciallytruewithsynopticreportingmandatedbyCancerCareOntario.Wearecurrentlyintheprocess

ofintroducingover60newsynopticreportformats.Thevolumeofrequestsforconsultationserviceshascontinuedtoincrease,likelyrelatedtoincreased

6.A1 – Anatomical Pathology – Surgical Pathology

Section 6 – Division Head & Medical Leader Reports

Report from Medical Leader of Surgical Pathology, Dr. C.M. McLachlin


SECTIO

N 6 – D

IVISION

HEA

D &

MED

ICA

L LEAD

ER R

EPOR

TS

scrutinyofpathologyservicesacrosstheprovince.Providingatimelyconsultationservicecontinuestobeapressureasthisworkmustbebalancedwith

internaldiagnosticneeds.

TheDepartmenthasfocusedconsiderableeffortinreviewingandenhancingourqualityinitiatives.UndertheleadershipofDr.HelenEttler,thePIQM

committeefocusingonqualityininterpretivepathologyhasbeenreviewingandstandardizingourproceduresinordertooptimizediagnosticquality.Weare

currentlydevelopingourProfessionalQualityManagementprograminlinewiththerecentlyreleasedStandards2Qualityinitiative.

ThedivisionofSurgicalPathologyhasseveralchallengesandopportunitiestomeetinthecomingyears.Theincreasingcomplexityofsurgicalpathology

materialandthegreaterexpectationsforadditionaltestingwillrequireameasuredapproachtotheinclusionofmoleculartechniques.OurDepartment

alreadyhassufficientexpertise;howeverprovidingresourcesfornewtestingremainsachallenge.Additionalchallengeswillincluderegionalinitiatives,

increasingworkloadandexpandingsubspecialtyexpertise.


SEC

TIO

N 6

– D

IVIS

ION

HEA

D &

MED

ICA

L LE

AD

ER R

EPO

RTS

TheautopsyfacilityatLHSC-UHopenedin2000andwasdesignatedasaRegionalForensicPathologyUnitbytheOfficeofthe

ChiefCoronerin2001.Allautopsiesrequestedbyfamilies(“hospital-consent”)ofin-patientsinanyoftheLondonhospitalsare

doneintheUHfacility.AllcasesinvestigatedbylocalcoronersaresenttotheUHservice.Inaddition,complexcoroners’cases

(e.g.homicides,criminallysuspiciousdeaths,pediatricdeaths)fromsouthwesternOntarioarereferredtoLondon.Accesstonotonlypathologistshaving

varioussubspecialtyexpertisebutalsootherexperts(radiology,dentistry,anthropology)ensureshighqualityresults.Thepathologistsaresupportedby

excellentstaff.

In2010,therewere522autopsiesdoneatUH.Ofthese,379werecoroners’casesand143werehospital-consentcases.ReferralsfromoutsideLondon

accountedfor126(33%)ofthe379coroners’postmortems.Basedon2009statistics,13homicideswerereferred.

Theautopsyservicecontinuestoplayanactiveteachingrole.Inadditiontointradepartmentalrounds,interactiveroundswithotherclinicalservices

(cardiology,intensivecare,neonatalandpediatricservices)areongoingacademicactivities.ForensicmedicinecoursesareofferedtoUWOundergraduates

andmedicalstudents.TheautopsyserviceisanessentialcomponentoftheMScPathologists’AssistantprogramofferedbytheDepartmentofPathology.

6.A2 – Anatomical Pathology – Forensic Pathology

Report from the Medical Leader of LHSC Autopsy Service & Director of Southwestern Ontario Regional Forensic Pathology Unit - Dr. M. Shkrum


SECTIO

N 6 – D

IVISION

HEA

D &

MED

ICA

L LEAD

ER R

EPOR

TS

TheCytologydivisionwithintheDepartmentofPathologyisrunbyateamconsistingoftheMedicalLeader(M.Joseph),

Coordinator(DonnaMurphy),9cytotechnologists,1.5labassistantsand12pathologistsofwhich4arecytopathologists.We

provideawiderangeofdiagnosticservicestoourphysiciansanddeliverexpertcytologyconsultationservicetoourregional

pathologists.

Lastyearweprocessed27,468samplesinthecytologylab(19,004gyn-cytology,8464non-gyncytology,ofwhich1938werefineneedleaspirationbiopsies

(FNABs).Therecentlyintroduced,stateoftheart,HologicThinPrepT5000processorhascertainlyimprovedtheefficiencyofcytopreparationinour

lab.OurcytotechnologistscontinuetoprovidetheFNABadequacyservicetoourclinicians(840caseslastyear)atallthreehospitalsitesandourclient

physicians’surveyhighlightstheremarkablebenefitofthisserviceforpatientcare.

OurcytologyteamworkedwithourLHSCphysiciansandestablishedprotocolsfortworecentlyintroducedtechnicallychallengingproceduresEUS-FNAand

EBUS-FNAandthesehavelargelyassistedgastroenterologyandrespirology/thoracicpatients.OurlabsuccessfullycompletedtheOLAaccreditationvisit

thankstoDonnaMurphyandherteamfortheirhardworkandcommitment.

6.A3 – Anatomical Pathology – Cytology

Report from the Medical Leader of Cytology, Dr. M. Joseph


SEC

TIO

N 6

– D

IVIS

ION

HEA

D &

MED

ICA

L LE

AD

ER R

EPO

RTSEducationisamajorthrustofourcytologydivision.Westrivetocreateastimulatingeducationalenvironmentbyteamteachingandpeerlearningwhichwe

believealsoenhancesteamrelationships.Ourrecentlyintroducedmultiheadmicroscoperoundsforcytotechnologistsandourtraditionalmonthlycytology

roundshavebeenredesignedtoimprovecommunicationandinteraction.OurteammembersareactivelyinvolvedintheongoingteachingofPathology

residentsandwearecurrentlydevelopingacurriculumforanexcitingCytologyFellowshipProgram.Equallyimportanttonoteisthatseveralofour

cytotechnologistsareClinicalEducatorswiththeMichenerInstituteofHealthSciences.

WerunarobustQualityManagementPrograminourcytologydivisionundertheleadershipofDr.M.Weir.OurteamisproudofourongoingQAandQC

programswithmanyprojectspresentedatnationalmeetings.Wearepleasedtostatethatphysiciansfromourcytologyteamparticipateontheexecutive

boardoftheCanadianSocietyofCytology,CanadianCoalitionforthePreventionofCervicalCanceraswellasintheScientificCommitteeoftheQuality

ManagementProgramandLicensingServiceofOntarioBranchoftheOntarioMedicalAssociation.

Cytologyisanevolvingscience.ThefutureofCytologyliesintheintroductionofnewertechnologiesandmoleculartesting.Thereareopportunitiesto

buildoncurrentareasofstrengthandexpertise.Thecollaborationandinteractionbetweencytopathologistsandsurgicalpathologistsmustincreaseinthe

researchfield.Aninventoryofcytologyresearchneedstobecreatedandmaintained,inordertoidentifywhereexpertiselays,wherecollaborationscanbe

encouraged,andwheregapsexist.

Challengeliespartlyinshortageofresources.IncreasingdemandsforFNABadequacyservicebyphysiciansatVictoriahospitalischallenging.Currently

weareworkingwithcliniciansatVictoriahospitalwhoutilizethisservicetostreamlinetheprocessusingcreativestrategies.WebelievetheLaboratory’s

successislinkedtoitsinterdisciplinaryteamapproach.Inordertosucceed,cooperationandcollaborationarerequiredamongallkeystakeholders.


SECTIO

N 6 – D

IVISION

HEA

D &

MED

ICA

L LEAD

ER R

EPOR

TS

TheMolecularPathologyGroup(MPG)atLondonHealthSciencesCentreiscomprisedofBiochemicalGenetics,Cytogenetics,

MolecularGenetics/DiagnosticsandMolecularPathologyandispartof11ProvincialRegionalGeneticCentres.Eachlaboratory

isheadedbyonespecializedMDand/orPhDwithtechnicalstafftrainedinmoleculargeneticsand/orcytogenetics.Eachofour

clinicaltestsrequireslicensurebytheMinistryofHealth.

Thebiochemicalgeneticslaboratoryprovidestestingforawiderangeofinheritedmetabolicdisordersaswellastherapeutic

monitoringtomanypatients.ItisareferencelaboratoryforSouthwesternOntarioandservesasaprovincialandnationallaboratoryforsometests.Itis

oneof4laboratoriesintheprovince.SectionHead:Dr.T.Rupar.

Thecytogeneticslaboratoryprovidesroutinechromosomeanalysis/karyotypingandmolecularcytogenetictesting(F.I.S.H.)formanyinheriteddiseases

(prenatal,perinatalandpostnatal)andacquiredcancers.Itservesmorethan1.6millionpeopleinSouthwesternOntarioandisoneof11laboratoriesinthe

province.SectionHead:Dr.J.Xu.

6.A4 – Anatomical Pathology – Molecular Pathology

Report from the Medical Leader of Molecular Pathology Group, Dr. J.H.M. Knoll


SEC

TIO

N 6

– D

IVIS

ION

HEA

D &

MED

ICA

L LE

AD

ER R

EPO

RTSThemoleculargenetics/diagnostics(oneof8intheprovince)andmolecularpathologylaboratoriesperformawidevarietyofgenetestingmethodologiesfor

inheriteddisorders,mitochondrialdisorders,predictivecancertesting,somaticdiseases(suchasleukemiaandlymphoma)andtherapeuticmonitoring(for

leukemia).Theyserveasreferencelaboratoriesforsometests.SectionHeads:Dr.P.Ainsworth(Genetics/Diagnostics),Dr.C.Howlett(Pathology).

Testvolumescontinuetoincreaseeachyear(10-20%onaverage)andtestcomplexitiescontinuetoincreasesignificantlyeachyear.Themajorityof

molecularteststhatweperformaremovingtowardscompletegenesequencingplatforms.Increasesintestvolumehavebeengreatestincancertesting

(withmorethan50%oftheworkloadassociatedwiththeCancerGeneticsProgram)butprovincialnewbornscreeningandnewbreastcancerscreening

regimentscontinuetoincreasetestvolumesinBiochemicalGeneticsandMolecularGenetics.

Thenumbersofdiseasesthatcanbe/shouldbetestedattheDNAandRNAlevelareincreasingandthetestingplatformsarechangingrapidly.Our

challengeistofindresourcestokeeppacewiththemedicalandscientificadvancementsandtoexpandourcapabilitiestobetterserveourpatient

population.

Duringthepastyear,thecytogenetics,moleculargenetics/diagnosticsandmolecularpathologysectionsofourgrouphavemovedtoanewcontiguous

laboratoryfacilityatVictoriaHospitalandintegrationofthemolecularunitsisnowinprogress.Wehavealsosecuredresourcestointroducemicroarray

testing(whichscreensthousandsofchromosomalloci)forhighresolutiondetectionofchromosomalrearrangementsininheritedandacquireddiseases.

Wehopetorecruitafull-timedoctorallevelspecialistinmoleculargeneticsandcytogeneticstokeeppacewiththeincreasedtestvolumeandtest

complexity,andimproveprofessionalcoverageforthesesubspecialties.

Inadditiontoclinicallaboratorytesting,theMolecularPathologyGroupcontinuestoplayanactiveandvitalroleinteachingofundergraduatestudents,

graduatestudents,medicallabtechnologystudents,residentsandfellowsatLHSCandUWO.


SECTIO

N 6 – D

IVISION

HEA

D &

MED

ICA

L LEAD

ER R

EPOR

TS

Fortheyear2010-2011,themembersoftheDivisionofOralPathologycontinuedtorespondtoincreasingdemandsinallareas

ofresponsibility.Thedemandfordiagnosticsandpatientcarecontinuestogrow.Tissuesfromdentistsanddentalspecialists

arereceivedfromacrossOntario,andconsultsarereceivedfrombothmedicalandoralpathologycolleaguesacrossOntario

andCanada.

Teachingdemandsalsocontinuetobehigh.Finetuningofthethreenewcoursesdevelopedforthenewdental

curriculumisinprocessaswelearnfrommistakesinpreviousyears.Thenewthirdyearcoursewillbegiven

forthefirsttimein2011-2012.Thereisconsiderablymoreadministrativeworkinvolvedwiththesecourses.

Researchcontinuestoprogress.Topicsincludetheinfluenceofhumankallikreinsinsalivaryglandneogenesis

andincystogenesisandneogenesisofodontogeniclesions.Researchonperiostin’sinvolvementin

odontogenicandfibro-osseouslesionsisalsobeingdone.Wenowhavefourgraduatestudentsandafifth

comingonboard.Twooftheseniorstudentsareinthewrite-upphase,whiletheothertwoaredoingactive

researchatthispoint.

6.B – Oral Pathology

Report of the Division Head of Oral Pathology, Dr. Tom Daley


SEC

TIO

N 6

– D

IVIS

ION

HEA

D &

MED

ICA

L LE

AD

ER R

EPO

RTS

InNovember2010thefinalmoveoflaboratoriestothe10thFloorBwingatVictoriaHospitaltookplace.Thissawthebringing

togetheroftheVirologylab,whichwassituatedatSJHC,andtheotherMicrobiologylabsintoonelocation.Thereisalsoashared

labfacilitywithmolecularpathologyandmoleculardiagnosticswhereweareabletoconsolidateourPCRdiagnosticmenu.This

movehasbeenmuchanticipatedandmuchappreciatedasourlabfacilitiesarenowspacious,modern,wellequippedandsomethingtobeproudof.

Amajorhospitalinitiativethisyearhasbeentoaddresstheissuesofpatientsafetyandpatientaccess.Infectioncontrolhasbeenanareaofgrowthinthis

regardandthelabsupportoftheinfectioncontrolprogramhasbenefittedbyacquiringnewtechnologies.Anewdiagnosticmethodforthediagnosisof

C.difficileisbeingintroduced.WewillalsobemovingtoidentifyingorganismsmorerapidlyusingtheMALDI-TOFFtechnology.Otherequipmentwillhelpus

streamlineourPCRwork.

DrZ.Hussainwillberetiringattheendofthisyear.Hewillbesorelymissedashehasbeenthemainstayofclinicalsupportfortheroutinediagnostic

microbiologylabaswellastheresidencyprogram.Wewishhimwellinhisretirement.Recruitmentisunderwayforareplacementandtheremaybe

opportunitiesforadditionalpositionsinmedicalmicrobiologytoprovidesufficientpersonnelfortheworkload.

6.C – Medical Microbiology

Report of the Medical Leader of Medical Microbiology, Dr. Rob Lannigan


SECTIO

N 6 – D

IVISION

HEA

D &

MED

ICA

L LEAD

ER R

EPOR

TS

Teachingthispastyearhascontinuedasbefore.ThenewmicrobiologycourseforPathologyassistantsstartedandwillbecontinuednextyear.The

microbiologyresidentisnowinhisfinalyearandwillbesittinghisRoyalCollegeexamsin2012.R.Lanniganhastakenovertheroleofprogramdirector

untilthisresidentisfinishedhistraining.Therearenoplanstotakenewresidentsunlessthereissufficientrecruitmentoffacultyandthereisafaculty

memberinterestedinrevampingtheprograminmedicalmicrobiology.

Researchcontinuestobeachallenge.ThisyearR.LanniganwaspartofateamthatwassuccessfulinobtainingagrantfromIDRCtoinvestigateCoastal

CitiesatRiskduetoclimatechange.


SEC

TIO

N 6

– D

IVIS

ION

HEA

D &

MED

ICA

L LE

AD

ER R

EPO

RTS

Report of Division Head of Neuropathology, Dr. L.C. Ang

TheDivisionofNeuropathologyintheDepartmentofPathologyattheLondonHealthSciencesCentreislocatedatUniversity

HospitalinLondon,Ontario,acityof350,000,andisthesoleteachinginstituteinSouthwesternOntarioservingapopulationof

morethan2million.

NeurosurgicalCases:wereceivein-housecasesfrom11neurosurgeonsandreferredcasesfromWindsor,Sudbury,Sarnia,Strathroy,Stratford,

Woodstock,Hamilton,Newfoundland,SaudiArabiaandSingapore.IntraoperativeconsultationsforadultCNStumourswereregularlyperformedat

UniversityHospitalwhilefrozensectionsforpediatricCNStumoursfromVictoriaHospitalwereperformedthroughtelepathologywiththeneuropathologists

stationedinUniversityHospital.

NeuromuscularCases:thesecasescomemainlyfromourneurologycolleaguesinLondonbutalsomanyfromWindsor,ThunderBay,Sudburyand

Waterloo-Kitchener.

Autopsybrains:casesexaminedintheyearincludedbothacademiccasesandcoroner’scases.Attendancebyneuropathologistsduringautopsyto

examineandsamplebrainsinunfixedstatehasincreasedbecauseoftheprovincialpolicyonorganretentionforcoroners’cases.

6.D – Neuropathology


SECTIO

N 6 – D

IVISION

HEA

D &

MED

ICA

L LEAD

ER R

EPOR

TS

Inaddition,Dr.RamsayobtainedconsultationsandreferralsforhisforensicneuropathologyexpertisefromalloverOntario.Dr.Angreceivedanumber

ofthedementiaandneurodegenerativecasesfromsouthwesternOntario.Dr.Hammondperformedneedlebiopsiesformusclediseasesandreceived

referralsfromthesurroundingregionsinSouthWesternOntario.The3careerneuropathologyresidentsandmanyrotatingresidentsalsoparticipatedin

theservice.

Theneuropathologylaboratoryisrunefficientlywithverywell-trainedandexperiencedtechnologistswhodealtwithneurosurgicaltissues,autopsy

brainsamplesandmusclehistochemistry.Thisdiagnosticserviceiswellsupportedbytheelectronmicroscopy,cytogenetic,molecularpathologyand

immunopathologydivisions.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Director of Education, Dr. David Driman

In2011,theorganizationoftheeducationalactivitiesoftheDepartmentofPathologywasrestructured,andaDirectorof

Education(Dr.D.Driman)wasappointedtooverseetheeducationalactivities.Mostofthechangescentredonundergraduate

teachingwhichwasrestructuredtoseparatetheprofessionalprogramsfromthenon-professionalprograms.Now,3committees

administerundergraduateteaching:Undergraduate–Pathology,chairedbyDr.C.Gibson(includesallBMSc/BScNprogram

teaching),Undergraduate–Medicine,chairedbyDr.M.Joseph(medicalstudentteaching)andUndergraduate–Dentistry,chairedbyDr.M.Darling(dental

studentteaching).Inaddition,aDepartmentofPathologyEducationCommitteewasformed,chairedbytheDirectorofEducation,withmembershipfromall

thecourseandprogramchairs(undergraduate,graduate,postgraduateandcontinuingprofessionaldevelopment).Themandateofthiscommitteeincludes

thefollowing:promotionofexcellenceinundergraduatepathologyeducation,promotionofresearchcollaborationthroughtheeducationalprogramsinthe

department,andtodevelopstrategiestofurtherpromotecurrenteducationalprograms,regulatefurtherprogramexpansionandtoimprovetheeducation

profileofourfaculty,nationallyandinternationally.

Section 7 – Department of Pathology Education Report


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Educational Program Organization


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

7.A – Postgraduate Programs

TheDepartmentofPathologyoffersintensive,integratedtrainingprogramsinAnatomicalPathology,MedicalMicrobiologyandNeuropathology.These

programsfulfilltherequirementsoftheRoyalCollegeandarefullyaccredited.Thetrainingprogramsmaybeusedtoembarkonacareerineitheran

academicorcommunityhospitalsetting.

TheDepartmentisacombinedclinicalandbasicsciencedepartment.Assuch,ourtrainingprogramsofferarangeofclinicalexperiencesandopportunities

forresearch.ProgramsapprovedbytheRoyalCollegeofPhysiciansandSurgeonsareofferedin:

I.AnatomicalPathology(ProgramDirector,JessicaShepherd)

II. MedicalMicrobiology(ProgramDirector,RobertLannigan)

III.Neuropathology(ProgramDirector,LeeCynAng)

ForinformationontheResidencyTrainingProgramspleasevisit:http://www.uwo.ca/pathol/postgraduate/index.html

Graduating Trainees – 2010 - 2011

Dr.MathieuCastonguay–AnatomicalPathology

Dr.SusanneChan–AnatomicalPathology

Dr.AreejShibani–AnatomicalPathology


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Therewere12residentsinAnatomicalPathology(AP)in2010-11,andnoneinGeneralPathology.Theresidents(PGY2-5)are

primarilylocatedatonesite,theUniversityHospitalDepartmentofPathology,andonlygooff-siteforFrozenSectioncoverage

ortoattendacademiceventsorrounds.TheyhavethebenefitoftheRegionalForensicUnitalsobeingon-site,aswellasa

parallelNeuropathologyProgram,sothereismuchbeneficialsharingoffacilitiesandeducationalinteraction,aswellasthe

formalrotationsofferedintheseareas.

27full-timefacultyanatomicalpathologistsparticipatedinteachingandmentoringourresidents.Allpathologistscovertwoormoresubspecialtyareas,as

membersofsubspecialtyteams.Onanygivenday,mostpathologistsareonsiteandinteractwithoneanotherinthehandlingofserviceandconsultwork.

Thisresultsinacomprehensiveandcohesivelearningexperiencefortheresidents,withbroadpracticalexposureandopportunityforrole-modeling.In

additiontopathologyresidents,therewasasteadystreamofoff-serviceresidentsandmedicalstudentsdoingelectives,aswellasobservers,suchthatthe

workingspaceintheresidents’roomswasalmostalwaysfilledtotheseams.

Thereweremanyeducationalrounds,includingdailyGrossRoomrounds,weeklyForensicandSurgicalPathologyrounds,atleastfortnightlySubspecialty

Microscopyrounds,monthlyJournalClub,GrandRoundsandICUrounds,aswellasmanyon-siteandoff-siteInterdisciplinaryroundsandTumourBoards.

7.A1 – Anatomical & General Pathology Resident Training Program

Report of the Program Director, Dr. J. Shepherd


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Residentswereheavilyinvolvedinteachingmedicalstudentsinsmallgroupsessions,aswellaseachother,throughoralpresentationsinroundsandas

minorcomponentsoftheirweeklyAcademicHalfDays.Residents,withtheexemptionofthePGY5s,presentedtheirresearchattheAnnualResearchDay

inApril,alongwiththegraduatestudentsfromthePathologydepartment.

IntheCaRMSmatch,bothofourPGY1positionswerematched,oneinthefirstiterationandtheotherintheseconditeration.TheprogramhadtwoPGY2

residents,twoPGY3residents,threePGY4residentsandthreePGY5residents.InSpring2011,allthreePGY5residentspassedtheRoyalCollege

specialtyexaminations,andwereacceptedintosubspecialtyfellowshiptraining,intheMayoClinic,theUniversityofToronto,andourowndepartment.


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Thereare3full-timefacultymembersinNeuropathology(Drs.Ramsay,HammondandAng)whoareinvolvedinthetrainingof

theresidentsinNeuropathologyasaspecialty,andmorethan25anatomicpathologistsinvolvedinthetrainingoftheseresidents

intheironeyearcompulsoryrotationinthespecialtyofAnatomicalPathology.ProgramadministrationhasbeenprovidedbyMs.

SusanStewartattheUniversityofWesternOntario.AlmostalltheclinicalteachingisconcentratedattheUniversityHospital.

Duringtheperiodofthisreport,therewere3careerneuropathologyresidentsintheprogram,oneinPGY4,onePGY3andoneinPGY2.Tworesidents

werefromSaudiArabiasponsoredbytheSaudiArabianGovernment.TheseresidentswillreturntoSaudiArabiaaftercompletingtheirresidency.The

otherresident,aCanadiancitizen,camethroughtheCaRMS.

Duringtheyear,anumberofAnatomicalPathologyresidents,NeurologyresidentsandNeurosurgeryresidentscompletedtheirelectivesinourprogram.

OneelectivepathologyresidentfromtheUniversityofManitobaspentamonthoftrainingwiththeprogram.Oneofourneuropathologyresidentsspent2

monthsinanelectiveforpediatricneuropathologyatUniversityofBritishColumbia.

7.A2 – Neuropathology Resident Training Program

Report of the Program Director, Dr. L.C. Ang.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Inadditiontoteachingduringbraincuttingandmicroscopicsign-outsessions,thereareweeklyunknownslidesessionsaswellasJournalClubfor

Neuropathologyresidents.ForAnatomicPathologyteaching,residentsarerequiredtoattendtheWednesdayacademichalfdayandWednesdaynoon

roundswiththeAnatomicPathologyresidentswhereAnatomicalPathologycasesarepresentedandForensicPathologyRoundsteachingwheregeneral

forensicpathologyisbeingtaught.

PathologyGrandRoundsandtheRobertZhongResearchSeminarsareheldeverymonth.

ForteachinginClinicalNeurosciences,therearetheGrandNeuroscienceRoundseveryTuesdaymorningforneurosurgeryandneurologycases,the

epilepsyroundsandneuroradiologyroundsweekly,andneuromuscularroundsmonthly,allofwhichresidentsaretoattend.AmonthlyNeuropathology

SlideTeachingSeminarisheldforallNeuropathology,NeurologyandNeurosurgeryresidents.

TwoneuropathologyresidentspresentedpapersattheCANPAnnualMeetingatOctober2010inToronto.


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Report of the Program Director, Dr. R. Lannigan.

TheMedicalMicrobiologyResidencyProgramoftheSchulichSchoolofMedicineandDentistryattheUniversityofWestern

Ontarioisafive-yeartrainingprogramandisapprovedbytheRoyalCollegeofPhysiciansandSurgeons.MedicalMicrobiology

isthebranchofmedicineconcernedwiththeprevention,diagnosis,andtreatmentofinfectionsandcommunicablediseases.

Thetrainingisaimedatdevelopingskillsinthefollowingspheresofactivity:

• Clinicalconsultationsontheinvestigation,diagnosisandtreatmentofpatientssufferingfrominfectiousdiseases

• Directionofinfectioncontrolprogramsacrosshealthcarefacilities

• Preventionandepidemiologyofcommunicablediseases

• Thescientificandadministrativedirectionofthediagnosticmicrobiologylaboratory

• Teachingatalllevels

• ResearchinbasicandappliedMedicalMicrobiology

7.A3 – Medical Microbiology Resident Training Program


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

TheMedicalMicrobiologyProgramisoneofthesmallerprogramsatWesternandusuallyhasonlyoneortwopostgraduatesatanygiventime.Theprogram

offersabroad-basedexperienceinlaboratoryandclinicalareas;thefiveyeartrainingincludesmandatoryandelectiverotations.Theprogramworksvery

closelywiththedivisionsofadultandpaediatricinfectiousdiseases.InfectiousDiseasesconsultantsparticipateactivelyinstructuringandsupervisionof

residenttraining.Monthlyrounds,journalclubarejointlyheld.ParticipationofIDconsultantsinacademichalfdaysofMedicalMicrobiologyisvaluable.

Theresidencycommitteestronglybelievesthatagoodfoundationinclinicalmedicine,especiallyininfectiousdiseasesisthebestfoundationforaMedical

Microbiologist.

Theprogramencouragesresearchandmostofourresidentshavehadseveralpublicationsinpeer-reviewednationalandinternationaljournalsandmade

presentationsatnationalandinternationalmeetings.Historically,graduatesofourprogramhavebeensuccessfulattheCanadiancertificationexamination

oftheRoyalCollegeofPhysiciansandSurgeons.Theyalsohavefounddiverseandrewardingcareers.

TheseareveryexcitingandchallengingtimesforMedicalMicrobiologyandInfectionControl.Newandemerginginfectiousagentsarebeingdiscovered,

diagnosticmethodologyischangingrapidly.OverthepastyearsMedicalMicrobiologistshavebeenattheforefrontinthefightagainstSARS,Avianand

SwinefluandWestNileVirusjusttonameafew.

2011-12 members of the Medical Microbiology Residency Training Committee

Dr.Anne-MarieBombassaro(ClinicalPharmacist,InfectiousDiseases)

Dr.ZafarHussain(SectionHead,Bacteriology)

Dr.MichaelJohn(MedicalDirector,InfectionPrevention&Control)

Dr.RobertLannigan(ProgramDirector,MedicalLeader,MedicalMicrobiology)

Dr.SameerElsayed(InfectiousDiseaseConsultant,Adult)

Dr.MarinaSalvadori(InfectiousDiseaseConsultant,Paediatrics)

Dr.MarvinMcGavin(AssociateProfessor,UWOMicrobiology&Immunology)

Dr.IanJamesStuart(ResidentRepresentative)

Pleasenotethattheprogramisnotcurrentlyacceptingapplicants.Afterthecompletionofthepresentresident’straining(June2012),theprogramwill

becomeinactive.


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Anatomic Pathology

BrianSchickPGY1

QiZhangPGY1

EssieMwamwenda-HeinrichPGY2

AllisonOsmondPGY2

RebekahJacquesPGY3

CadyPocrnichPGY3

MaraCarageaPGY4

IramSiddiquiPGY4

EmilyFilterPGY4(eff.July31st)

AdinaIrimiesPGY5

HectorLiChangPGY5

SamiSiddiquiPGY5

Neuropathology

MuradAlturkustaniPGY4

DasSumitPGY3

FahdAlSufianiPGY3

Medical Microbiology

JamesIanStuartPGY5

7.A4 – Trainees at July 1st 2011


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Awards

•IramSiddiquiwasthewinnerofthe2010DonaldRixAwardforherposterpresentationatthe61stAnnualScientificMeetinginMontreal,Quebec–

July10th,2010.

•SusanneChan,researchpaperentitled“AnIn-depthStudyofExtraprostaticExtensionandMarginStatusinRadicalProstatectomies”wasselected

asoneofthewinnersofthe2010PSIFoundationsResidentResearchAward.

•MuradAlturkustaniwasawardedtheCanadianAssociationofNeuropathologists’stopscientifichonour,theMorrisJ.Finlaysonaward.

Publications & Presentation

•POSTERSpresentedattheCAPmeetinginMontreal,July2010:

oAdinaIrimies,M.G.JosephandM.Gabril.BasalCellCarcinomawithPilomatricalDifferentiation:ACaseReportandReviewoftheLiterature.

oIramSiddiqui,DavidK.Driman,AaronHaig,BrianM.Taylor,ManalY.Gabril.AdenocarcinomaArisinginCysticRectalDuplication,Precededby

RetrorectalDermoidCyst:ACaseReport.

•CanadianAssociationofNeuropathologistsmeeting,Vancouver,October2011

oMuradAlturkustani,FahdAlSufianiandSumitDasdeliveredplatformpresentations

Alumni Update

•Dr.ChadLuedtkewentontodoaoneyearBreastPathologyfellowshipinNewYorkCityatMemorialSloan-KetteringCancerCenter,andisnow

onstaffinCalgary.

•Dr.HarkiranKaurhascompletedaoneyearGynecologicalandBreastPathologyfellowshipinToronto(UniversityofToronto).


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

7.B – Graduate Education Programs

TheDepartmentofPathologyGraduateProgramhasexperiencedunprecedentedgrowthoverthelastseveralyearsbecauseofimplementationofsome

creativeideasbythepreviousgraduatechairDr.SubrataChakrabarti.Examplesofsomeoftheseareintroductionofapart-timegraduateprogram(both

atM.Sc.andPhDlevels),recruitmentofseveralclinicianscientistsandbasicscientistsfromsomeotherclinicaldepartmentstoourPathologyGraduate

Program,introductionofacollaborativegraduateprogrambetweentheenvironmentalpathologyprogramandtheecosystemhealthprogram,andby

launchingofacoursebasedPathologists’Assistant(PA)graduateprogram.Asofthisfall,thePAprogramhasbecomeaseparatestand-aloneprogram.

TheDepartmentofPathologyiscommittedtograduateeducation,thoughfurthergrowthinourgraduateprogramhasbeenlimitedbythenumberof

graduatefacultymembersinourdepartment.Thishaslargelybeenduetoalackofresources,specificallyspace,makingitimpossibleforthedepartment

torecruitnewscientistsintheDepartmentofPathologyatUWO.

7.B1 – Research Based Graduate Program

Report of the Graduate Chair, Dr. Chandan Chakraborty

ResearchtrainingisprovidedbothattheM.Sc.andatthePh.D.levels.Thisisanintegratedresearchprogramand

investigationoccursatthemolecular,cellular,tissue,wholeorganism,andclinicallevels.Studentscarryoutsupervised


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

researchinvariousthematicareas,includingcancer,diabetes,transplantation,stemcellbiology,neuroscience,cardiovascularscience,developmental

defects,moleculargeneticsandtoxicology.Thegoalofourgraduateprogramistocreatetomorrow’sresearchers;scientistswhowillmakesignificant

originalcontributionstotheglobalunderstandingofdiseasediagnosisandmechanisms.Graduatesfromourprogramarequalifiedforadiversesetof

careersincludingacademia,government,andthepharmaceuticalindustryandhavebeensuccessfulineachofthesesectors.Tofurtheraddressthespecific

needfortomorrow’sscientistsandtotrainclinician-researchers,anunder-resourcedprofessioninCanada,wehaveinitiatedasuccessfulpart-timeresearch

basedgraduateprogram.

Graduate Student Enrollment

Inthepastseveralyearswehaveexperiencedanunparalleledgrowthinourpathologygraduateeducationprogram.Fromatotalof14M.Sc.and6Ph.D.

studentsinSeptemberof2005,enrollmenthasincreasedto36M.Sc.and11Ph.D.studentsinSeptemberof2010See[Table1].Thisisduetoseveral

reasonssuchasanincreasedintakeofgraduatestudentsbyourexistingfaculty,andtheinitiationof:a)aparttimegraduateprogram;b)theecosystem

healthgraduateprogram;c)anoralandmaxillofacialsurgeryprogram;andd)thePAtrainingprogram.OurachievementsfulfillthemandateofUWOto

increasegraduatestudentenrollment.Ourfacultymembersareverysuccessfulinrecruitinghighqualityresearchstudentsintotheirresearchlaboratories.

Table 1 – Enrollment in Pathology Graduate Programs

AcademicYear MScFT MScPAFT MScPT** MScTotal PhDFT PhDPT PhDTotal TotalFT TotalPT Total2005-2006 11 0 3 14 5 1 6 16 4 202006-2007 9 0 4 13 3 2 5 12 6 182007-2008 10 4 4 18 5 1 6 19 5 242008-2009 9 8 3 20 4 2 6 21 5 262009-2010 15 8 6 29 5 2 7 28 8 362010-2011 18 8 10 36 9 2 11 35 12 472011-2012 8 8 11 27 11 2 13 27 13 40

Note:StudentswhoareonaLeaveofAbsencearenotincludedinthisdata

**MScPT–3OralMaxiofacialStudentsareincludedeventhoughtheyarenotcounteduntilthe4thyearoftheirdegree.

Webelievethatourresearch-basedgraduateprogramcanexpandfurther.However,continuedgrowthofthisprogramhasbeenhinderedbythelackof

sufficientgraduatesupervisors.ThisisinsharpcontrasttoseveralotherprogramsinSchulichwherelackofexpansionisduetolackofqualifiedstudent

applicants.Overthelast10years,theoverallnumberofBasicSciencefaculty(includingOralPathologists)appointedinPathologyhasslightlyincreased

from5scientistsin1999to7asof2009.AlthoughwesuccessfullycompetedforoneUPIFpositioninthelastfiveyears,thisissignificantlylowerthanthe


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Table 2 – Graduate Faculty

Name Rank Home DepartmentAdams,PaulC Professor/MD MedicineAng,Lee-Cyn Professor/MD PathologyBend,JohnR Professor PathologyBurneo,JorgeG AssistantProfessor/MD ClinicalNeurologicalScienceChakrabarti,Subrata Professor/MD PathologyChakraborty,Chandan AssistantProfessor PathologyChambers,AnnF Professor OncologyChan,Nancy AssistantProfessor/MD PathologyDaley,ThomasD Professor PathologyDarling,MarkR AssistantProfessor PathologyDhanvantari,Savita AssistantProfessor MedicalBiophysicsGarcia,Bertha Professor/MD PathologyGibson,Candace AssociateProfessor PathologyHammond,RobertR Professor/MD PathologyHerbert,CarolP Professor FamilyMedicineHowlett,Chris AssistantProfessor PathologyHutnik,Cindy AssociateProfessor/MD OphthalmologyJevnikar,AnthonyM Professor/MD Medicine

incrementalfacultyrecruitmentthathasoccurredinseveralotherdepartmentsoverthesametimeframe.AsthenewChairandChiefofPathologyand

LaboratoryMedicine,Dr.SubrataChakrabartihasbeenabletonegotiate2facultypositions(onebasicscientistandoneclinicianscientist)andlaboratory

spaceforthem.Inaddition,theDivisionofMedicalMicrobiology,DepartmentofPathology,isintheprocessofhiringaMedicalMicrobiologistwithstrong

researchbackground.Thispersonwillbeacceptinggraduatestudent(s)throughtheDepartmentofPathology.Theserecruitmentswillhelptofurthergrow

ourresearch-basedgraduateprogram.

Faculty supervisors and research areas

ThePathologyDepartmentcurrentlyhas37Pathologyfacultymembersapprovedforgraduatestudentsupervision,thoughsomeofwhomareheavily

involvedinthePAtrainingprogram.Severaloftheseindividualsarealsomembersofinterdisciplinarygraduateprograms.Table2belowlistsourgraduate

facultymembers.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Joy,Tisha AssistantProfessor/MD MedicineKarlik,Stephen Professor PathologyKhan,Zia AssistantProfessor PathologyKnoll,Joan Professor PathologyKoropatnick,James Professor OncologyMegyesi,Joseph AssociateProfessor PathologyMin,Wei-Ping AssociateProfessor SurgeryMoussa,Madeleine Professor/MD PathologyNichols,Anthony AssistantProfessor otolaryngologyPeng,Tianqing AssistantProfessor MedicineRieder,Michael Professor/MD PediatricsShkrum,Michael Professor/MD PathologyStrong,Michael Professor/MD ClinicalNeurologicalScienceTrick,Charles Professor BiologyTuck,Alan AssociateProfessor PathologyWang,Rennian AssociateProfessor Physiology&PharmacologyWang,Hao AssistantProfessor/MD SurgeryWhite,David Professor SurgeryZhang,Zhu-Xu AssistantProfessor Medicine

Department of Pathology Graduate Education Committee

Dr.ChandanChakraborty(GraduateProgramChair)

Dr.JackBend,DirectorofResearch

Dr.ZiaKhan

Dr.HaoWang

Dr.CandaceGibson

Dr.NancyChan(ProgramDirector,PAprogram)

Dr.MadeleineMoussa(representativefromPAprogram)

ArthurLau(GraduateStudentRepresentative)

Dr.SubrataChakrabarti,(Chair/Chief,DepartmentofPathology)

Ms.TraceyKoning(Ex-Officio–GraduateAffairsAssistant)


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

7.B2 – Course & Practicum Based Graduate Program

Report of the Program Director, Dr. Nancy Chan

PA Program Graduates – Career Opportunities

Thereisagreatandwell-documentedneedforwell-trainedPAsinCanada.Thereareabout225communitylabsinOntarioand

thevastmajorityofthemdonothaveaPA,largelyduetodemandexceedingsupplies.WeexpectthatifwelltrainedPAsare

available,eachoftheselabswillhireatleastone.Thelargercenterspotentiallywillrecruitmorethanone.Althoughtheacademic

centersinOntariohavePAs,suitablytrainedPA’sareinveryshort-supply.

Additionalpossibilitiesforemploymentexistinotherprovincesaswellasintheforensiccenters.Itisalsoexpectedthatoverthenextseveralyearsthisneed

willcontinuetoincreasebecauseofthesevereshortageofpracticingpathologistsandpathologists-in-training,requiredtomeetescalatingclinicaldemands.

Graduatingtraineesin2010-2011includeonestudentwhowillworkasapathologist’sassistantinLethbridge,Alberta;onestudentwillworkasa

pathologist’sassistantinHalifax,NovaScotia;onestudententeredmedicalschoolattheUniversityofToronto;onestudenttookaleaveofabsence.

Course & Practicum Based Graduate Education Committee

Dr.S.Chakrabarti(ProgramDirector,exiting)

Dr.NancyChan(ProgramDirector;new)

Dr.MikeShkrum(MedicalDirector)

Dr.BerthaGarcia(Chair/Chief,DepartmentofPathology)

Dr.CandaceGibson

Dr.MadeleineMoussa(replaceDr.Gibsonwhileshewasonsabbatical)

Mr.MikeGraves(ClinicalCoordinator)

Dr.RickMann,RegionalSupervisingCoroner(CommunityMember)

MsTraceyKoning(GraduateProgramAdministrator)

MsKatherineGreenall(PAstudentrepresentative)

Future Directions

Thisisaninnovativenewprogramwithroomtogrow.ThePathologyGraduateProgramwentthroughanOntarioCouncilonGraduateStudies(OCGS)

reviewin2010,andwehadoursitevisitonMay2011.Ithasbeendeterminedthatourfutureplansincludeexpansiontoaccommodatemorestudentsand

separatingitintoitsownstand-aloneprofessionalprogram.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

7.B3 – Graduate Student Publications & Presentations •EmilyKeats(PhDcandidate,supervisorDr.ZiaKhan)andRokhsanaMortuza(PhDcandidate,supervisorDr.SubrataChakrabarti)presentedat

the71stAmericanDiabetesAssociationConferenceinSanDiego.

7.B4 – Graduate Student Awards (2010-2011) •MargaretMoffatResearchDay-2011PosterCompetitionAwardWinners–ManpreetSingh(MSc,supervisorTianqingPeng),PhaedraHenley

(PhD,supervisorsJackBend&CharlieTrick).

•MSccandidateCarolineWhiston(supervisorsDr.AlanTuckandDr.AnnChambers)receivedtheCIHRBanting&BestMastersAward.

•MSccandidateConnorMacMillan(supervisorsDr.AlanTuckandDr.AnnChambers)receivedanNSERCaward.

•AndrewPepper,PhDCandidate,withDr.DavidWhitehasreceivedanawardfromMITACSAcceleratePhDFellowshipProgram(www.mitacs.ca).

•OntarioGraduateScholarships:ArthurLau,MScCandidate(ResearchProgram),VanessaMeunier,MScCandidate(PAProgram),Maria

Queques,MScCandidate(PAProgram),YuexiuWu,PhDCandidate(ResearchProgram)

•PhDcandidateAndrewPepper(supervisorDr.DavidWhite)attendedtheCanadianStudentHealthResearchForumheldinWinnipeginJune,

2010.TheSchulichSchoolofMedicine&DentistryselectedthetopPhDstudentsfromSchulichGraduateProgramstoattendtheforum.

Name Program Supervisor Future PlansDarkoZdravic MSc Dr.C.Chakraborty PhDatUniversityofTorontoJenniferMutrie MSc Drs.A.ChambersandA.Tuck TeachersCollege,UWONicolePark MSc Drs.J.KnollandP.Rogan PhDatUniversityofTorontoAbudiAwaysheh MSc Dr.JackBend 3rdyearLawCo-opstudentatUniv.ofBritishColumbiaLesleySouter PhD Drs.A.ChambersandA.Tuck LookingforajobAminaIftekhar MSc Drs.T.PengandS.Chakrabarti AppliedforadmissionintothePhDprogramatUniv.ofTorontoBrianKeller MSc Dr.M.Strong WorkinginDr.Strong’sResearchLabManpreetSingh MSc Dr.T.PengandS.Chakrabarti ApplyingtoMedicalSchoolsinOntarioLeiZhang MSc Drs.J.BendandRieder LookingforajobXushengZhang MSc Dr.W.P.Min WorkinginaresearchlabatLHSC-UH

7.B5 – Alumni Update: 2010-2011 Department of Pathology Graduates


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

7.B6 – Graduate Course Offerings (2011-12 Academic Year)

PATHOLOGY GRADUATE COURSES

New Course Number Course Title Old Course Number Section Coordinator TermCourses for Pathology Research Based MSc Students

9510(beingphasedout) JournalClub 510Y 001 C.Chakraborty Sept-Apr9511(beingphasedout) JournalClub 511Y 001 C.Chakraborty Sept-Apr9555(Yr1) JournalClub 9510 001 C.Chakraborty FallTerm9556(Yr1) JournalClub 9510 001 C.Chakraborty WinterTerm9557(Yr2) JournalClub 9511 001 C.Chakraborty FallTerm9558(Yr2) JournalClub 9511 001 C.Chakraborty WinterTerm9240 Understanding

Disease240A 001 A.Haig Sept-Dec

Courses for Pathology Research Based PhD Students9610(beingphasedout) JournalClub 610Y 001 C.Chakraborty Sept-Apr9611(beingphasedout) JournalClub 611Y 001 C.Chakraborty Sept-Apr9665(Yr1) JournalClub 9610 001 C.Chakraborty FallTerm9666(Yr1) JournalClub 9610 001 C.Chakraborty WinterTerm9667(Yr2) JournalClub 9611 001 C.Chakraborty FallTerm9668(Yr2) JournalClub 9611 001 C.Chakraborty WinterTerm9240 Understanding

Disease240A 001 A.Haig Sept-Dec

Courses for Pathology to all students offered every other year9500 Biologyof

HumanCancer500b 001 J.Koropatnick Jan-Apr

9520 Public&PartnershipinCancerResearch

520b 001 J.Koropatnick Jan-Apr

Ecosystem Health Graduate Program9514 Ecosystem

Health514b 001 J.Bend Jan-Apr


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Courses for Pathologists’ Assistant Graduate Program9245 Diseasesof

OrganSystems240B 001 C.Howlett Jan–Apr

9561 FunctionalHistology

561 001 N.Chan Sept–Apr

9562 InfectiousDiseases&Pathology

--- 001 K.Kwan Sept-Apr

9540 EnvironmentalPathology

540 001 C.Chakraborty Jan–Apr

9541 EnvironmentalPathology–SpecialTopic

--- 001 C.Chakraborty Jan-Apr

9550 IntrotoForensicSciences

550 001 M.Shkrum Jan–Apr

9551 IntrotoForensicSciences–SpecialTopic

--- 001 M.Shkrum Jan-Apr

9575 GrossSurgicalRotation

575 001 N.Chan May-Apr

9570 AutopsyRotation


9585 ResearchProject


Courses PAs are required to take in other Departments9560 Human

Anatomy,Embryology

560 001 M.Johnson Sept-Apr

New Courses being offered in Fall 20119100 Health

Informatics001 C.Gibson Sept-Apr

9110 HealthInformationManagement

001 C.Gibson Sept-Apr


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

7.C – Undergraduate Education Programs

TheDepartmentofPathologyhashadalongstandingcommitmenttoteachingstudentsattheundergraduatelevelwithinthefacultiesofMedicineand

Dentistry,Science,andHealthSciences.

TheDepartmentofPathologyoffersundergraduatepathologycoursesandtrainingtomedicalstudents,dentalstudents,nursingstudents,andseveral

undergraduatepathologycoursesinthejointspecializationinPathologyandToxicology,opentostudentsintheBMSc/BScprograms.

7.C1 – Undergraduate BScN / BMSc

Dr. Candace Gibson, Undergraduate Chair

a. BMSc (NURSING)

Anonlinecourse(Pathology2420A)ingeneralandsystemicpathologyisofferedtothenursingstudentsinthecollaborative

UWO-FCBScNprogramandintheCompressedTimeFramenursingprogramatUWO.

Thisisasurveycourseprovidinganunderstandingoffundamentalmechanismsofdiseaseprocesses.Thefirsthalfofthecoursepresentspathogenesisof

diseasescommontoallorgansystems;thesecondhalfconcentratesondiseaseinmostofthemajororgansystemsincludingcardiovascular,respiratory,

gastrointestinal,genitourinary,nervousandmusculoskeletalsystems.

ExtraInformation:2lecturehours/wkorequivalentonlinedeliverywith1tutorialhour/wk,0.5course.EnrollmentlimitedtostudentsintheWestern

FanshaweCollegecollaborativeBScNprogram.

b. BMSc – Pathology & Toxicology

In2005PathologyintroducedaBachelorofMedicalSciencesHonorsSpecializationandaSpecializationinToxicology&Pathologyofferedconjointlywith

theDepartmentofPhysiology&Pharmacology.InthefollowingyearfulladministrationoftheprogramwastransferredtotheDepartmentofPathologyand

thespecializationswererenamedPathology&Toxicology.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Scope of the Program:

Wecurrentlyteachhumanpathologyto:

•Thirdyearmedicalsciences,biologicalsciencesandhealthsciencesstudents

•Fourthyearmedicalsciences,biologicalsciencesandhealthsciencesstudents

•AnumberofgraduatestudentsfromourownprogramaswellastheprograminClinicalAnatomyalsotakethethirdyearPathologycourses

WeoffertwomodulesintheBachelorofMedicalSciences(BMSc)program:

•HonorsSpecializationinPathology&Toxicology

•SpecializationinPathology&Toxicology

StudentsenterthesemodulesinthesecondyearfollowingageneralfirstyeartakenthroughtheFacultyofScience(thatincludesintroductorychemistry,

physics,mathematicsandbiologycourses).ThestudyofPathologyattractsoutstandingstudentsandthehonorsspecializationinPathology&Toxicology

hasthedistinctionofhavingthehighestentranceaverageamongtheBMScmodule.

TheprogramunderwentitsfirstSUUPRreviewin2010-11,alongwiththeothermodules/programswithintheBMScprogramattheSchulichSchoolof

Medicine&Dentistryandwasgivena“GOODQUALITY”rating.Theprogramwillbereviewedagaininsevenyearsandseveralinitiativesareunderwayto

continuetogrowandmaintaintheprogram.

Pathology 3240A - Understanding Disease Mechanisms

Asurveycourseforstudentsinthebiomedicalsciences,healthsciencesorscienceprograms.Theemphasisisonunderstandinggeneralmechanismsof

disease(e.g.inflammation,immunity,injury,neoplasia,disturbedhemodynamics)inallorgansystems.OfferedthroughtheDepartmentofPathologyinthe

SchulichSchoolofDentistryandMedicine.NotaFacultyofSciencecourse.

25hoursoflecture

Pathology 3245B – Diseases of Organ Systems

BuildingontheknowledgeofgeneraldiseasemechanismspresentedinPathology3240A,thislecture-basedcoursewillintroducestudentstospecific

diseasesofmostmajororgansystems(e.g.cardiovascularsystem,respiratorysystem,renalsystem,GIsystem,reproductivesystem,centralnervous

systemandmusculoskeletalsystem).

Prerequisite(s):Pathology3240Awithaminimummarkof70%.

26hoursoflecture


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Pathology 4400B - Environmental Pathology

Thepathologyofoccupationalandenvironmentaldiseases,includinginformationonrecentdevelopmentsandbasicmechanismsinvolvedinthese

diseases.Recognitionofoccupationalandenvironmentaldiseases,earlydiagnosis,mechanismsofcellinjuryandregeneration,andtheeffectsofawide

varietyoftoxicdrugs,chemicalsandUVandionizingradiationareincluded.

Prerequisite(s):Pathology3240Aand3245Bwithaminimummarkof70%ineach.

26hoursoflecture

Pathology 4500B- Introduction to Forensic Sciences

Examinationofthemedicolegalframeworkinvestigatingthenatureandcircumstanceofcertaindeaths.Theseforensicinvestigationsinvolveexpertsin

differentdisciplinesassistingthecoronerandpoliceinresolvingcases.Forensicpathologyexaminestheeffectsofdisease,particularlyinsuddendeath,

andeffectsofvariousexternalagentsonthehumanbody.

Prerequisite(s):Pathology3240Aand3245Bwithaminimummarkof75%ineach.RestrictedtostudentsinYear4ofPathologyandToxicologymodules.

LimitedspacesavailabletostudentsinYear4ofotherBasicMedicalSciencesandBiologicalSciencesmodules,withpermissionofthecoursedirector.

26hoursoflecture

Pathology and Toxicology 4980E – Seminar and Research project

Includes:i)theoryandpracticeoflaboratorytechniques,laboratorysafety,appropriateuseofexperimentalmodels,ii)anindependentresearchproject

supervisedbyfaculty,iii)oralandwrittencommunicationskills,includingthepreparationofaresearchproposalandfinalwrittenresearchprojectreport.

Prerequisite(s):Pathology3240AandPathology3245B,withamarkofatleast75%ineach;Pharmacology3550A/Band3560A/B,ortheformer357;

Physiology3120;andregistrationintheHonorsSpecializationinPathologyandToxicology.

Pre-orCorequisite(s):Pathology4500B.

ExtraInformation:Minimum11laboratoryhoursperweekplus1seminarhourperweek.1.5course.

c. Undergraduate Course Enrolment Data

EnrolmentinthePathologycourses(seeappendedcourselisting)hasbeensteady(apeakcoincidentwiththedoublecohortoccurredin2006-07).Interest

inthesecourses,particularlyinthethirdyearintroductorysurveycourses,ishighandweexpectittoremainatcurrentlevels.Enrolmentinthe4thyear

forensicsciencecourseislimitedinpartbecauseofthesensitivenatureofthematerial(i.e.itisnotappropriateasageneralinterestcourse)andalso

becauseitisgiveninconjunctionwiththe4thyearmedicalstudentelectiveinForensicPathology.TheBMScstudentsreceivepartoftheirinstructionalong

withthesestudents.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Undergraduate Course 2007-2008 2008-2009 2009-2010 2010-2011 2011-2012Path240A 162 --- --- ---Path3240A --- 148+12grads 159+15grads 154+16gradsPath3245B --- 80+4grads 91+4grads 100+4gradsPath4400B 42+2grad 32+3grads 39+3grads 40+4gradsPath4500B 25+2grad 27+3grads 22+3grads 25+5gradsPath-Tox4980E 10 9 5 14

Objectives of our Undergraduate Program:

Theobjectivesofourintroductorythirdyearpathologycourses(Pathology3240Aand3245B)aretogivestudentsageneralknowledgeandunderstanding

ofdiseaseandtogivethestudentsomeofthebasicdescriptivevocabularyofdiseaseprocessesandobtainanunderstandingofdiseaseprocessesand

theirunderlyingmolecularmechanisms.Pathology3240Aintroducesstudentstodiseaseprocessessuchasinjury,inflammation,immunity,infectionand

neoplasiathatarecommontomanyorgansystems(i.e.generalpathology).

Inouradvancedcoursesinthe4thyearweofferamoreindepthstudyoftwoareasofcurrentinterestinpathology–environmentalpathologyandforensic

pathology.Thesecoursesreflectnotonlytheinterestandimportanceoftheseareaswithinpathologybutalsoreflectinterestsandareasofstrengthin

researchamongourfacultymembers.

Theobjectiveofthe4thyearseniorresearchprojectistointroducethestudenttothestudyofpathologywithinabasicscienceorclinicalpathologyresearch

laboratoryundertheguidanceofapathologyfacultymember.Themajorityofthesupervisorsof4thyearstudentsarealsomembersofthegraduatefaculty

inPathology.Additionallyseveralopportunitiesareofferedforclinicallybasedresearch.

Priorities/Considerations for the Future:

•Wewillreviewcoursesandofferings–possibleintroductionofahistopathologycourse(4thyearlevelwithACB3319–histologyasa

prerequisite);interdisciplinarystemcellbiologycourse;

•Wehaveintroducedtwonewcoursesinhealthinformaticsthatareofferedatthegraduatelevelandareavailabletoourundergraduatestudents

andwillformpartofanewlyproposedinterdisciplinarymoduleinMedicalHealthInformaticsacrosstheFacultyofScienceandtheSchulichSchool

ofMedicine&Dentistry


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

•MonitortheupcomingchangesinToxicologythatwilloccurintheDeptofPhysiology&Pharmacologywithretirements,etc–possibilityofoffering

amoleculartoxicologycoursethroughPathology;thiswillbemorefullyinvestigatedanddevelopedinthecomingyear(2012)

•Wehaveincreasedourintakeofstudentsin2ndand3rdand4thyearsofthePathology&Toxicologymodule;enrolmentin4thyear,atthe

moment,iscappedat15whichisthemaximumnumberofstudentswhocanbereasonablyaccommodatedwithcurrentresourcesandfaculty

members.

•WewillmonitortheincreasedintakeofstudentsinthefirstyearoftheBMScprogramthathasoccurredin2010and2011aspartofthegeneral

increasedintakeofstudentsonUWOcampusandadjustintakeofstudentswithinthe3rdand4thyearlecturebasedcoursestoaccommodate

themaccordingly(thefirstincreasewillimpactthedepartmentin2012-13).

Pathology & Toxicology – Graduating Students 2010-2011

Student Name Supervisor(s) Project Boo,StellarHyeeun Drs.LinaDagnino&JackBend Potentialroleofintegrin-linkedkinaseinTGF-β-mediatedmyofibroblast

differentiationBowie,LauraErin** Dr.SteveKarlik Anti-neuroinflammatoryeffectsofginsengextractsCipkar,Christopher Dr.TianqingPeng TheroleofmiR-195indiabeticheartdiseasesClem,James Dr.EdithArany Type2diabetes,nutrition,andepigeneticsHeo,EileenChristinaDayon Dr.JohnR.Trevithick Modelingdiabeticretinopathy:riskreductionbyexercise,and/orOntarioginseng

aIcoholandwaterextractstoreducetheriskofretinalcapillarypermeability

changesMatthews,Nicola Drs.WeipengMin&XiuFenZheng TargetedsiRNAdeliveryusingnanoparticlesforRNAi-basedtherapeuticsSkeldon,MatthewJamesTadashi Drs.MarcoPrado&JackBend CellularandmolecularbasisofneurodegenerativediseasesThomas,AshleyLouise Drs.XiuFenZheng&WeipengMin Anti-tumoreffectofantimicrobialpeptideonbreastcancerTsoi,MarissaYanYin Dr.RobHammond Whole-slidequantitativedigitalpathologyWei,Yiming Drs.JackBend&MichaelRieder Attentuationofadversedrugreactionswithanoxidativestresscomponentby

antioxidantandimmunomodulatoryconstituentsoftraditionalchinesemedicinesWelten,Cassandra Dr.ZiaA.Khan Roleofstemcellsinhemangioblastoma(tentativetitle)Xu,AlexXiaoHui Dr.HaoWang Theroleofanti-CD200inpreventionofacuteallograftrejectioninamouserenal

transplantationmodelYan,Alexander Dr.Zhu-XuZhang TheroleofNKcellsinchronicallograftvasculopathyZhang,Angela(Qiao) Dr.CindyL.Hutnick Theroleofconnexingapjunctionsinhumantrabecularmeshworkcellline

exposedtooxidativestress

**WinneroftheGoldMedalinPathology&Toxicology


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

IneachcoursetherearePathologylectures,aswellaslecturesinvariousothersubjectareasasappropriatetothatsystem.Asindicatedbytheitalicized

namesabove,Pathologyfacultyplayastrongleadershiproleinthesecourses.

The third and fourth yearsofthemedicinecurriculumincludea52weekintegratedClerkship(Medicine5475),ClinicalElectives,andtheMedIV

Integration,ConsolidationandEnrichment.

7.C2 – Undergraduate Medicine

Dr. Mariamma Joseph, Undergraduate Medicine Chair

UndertheleadershipofDr.DavidDriman,DirectorofEducation,DepartmentofPathology,anUndergraduatePathology

Medicinecommitteehasbeenrecentlyestablished(ChairDr.M.G.Joseph)topromoteexcellenceinundergraduatemedical

education(UME)throughinnovationinPathologyteachingandtoaddressandresolveissuespertainingtoUME.Ourmain

objectiveistopromotevisibilityofPathologytomedicalstudentsandenhancementstoconsiderationofPathologyasacareer

choiceatthesametime.

SinceSeptember2008theSchulichSchoolofMedicine&Dentistry’sDoctorofMedicineProgramhasrunsimultaneouslyfromtwosites:London,Ontario

andWindsor,Ontario.In2010-11therewere133studentsenrolledattheLondonsite,and38studentsintheWindsorprogram.TheWindsorprogramisa

partnershipbetweenTheUniversityofWesternOntario,TheUniversityofWindsor,andtheLondonandWindsorhospitals.

Thefirsttwoyearsofthemedicalcurriculumprovidethestudentswithasolidgroundinginthebasicandclinicalsciences.Thesetwoyearsareeachdivided

intoaseriesofsystems-basedcourses:

Med I Courses

•IntroductiontoMedicine

•Blood&Oncology(CourseCo-Chair,Dr.K.Rizkalla)

•Infection&Immunity

•Skin(CourseChair,Dr.M.G.Joseph)

•Heart&Circulation(CourseCo-Chair,Dr.E.Tweedie)

•Respiration&Airways

•GenitourinarySystem

Med II Courses

•DigestiveSystem&Nutrition

•Endocrine&Metabolism

•Reproduction(CourseCo-Chair,Dr.M.Weir)

•MusculoskeletalSystem

•EmergencyCare

•Neurosciences,Eye&Ear

•Psychiatry&BehaviouralSciences


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

Meds III – Clinical Clerkship Pathology Electives (Co-ordinators Dr. H. Ettler, Dr. A. Haig and Dr. K. Kwan)

Duringthe2weeks,theclerkwill,underthedirectsupervisionofapathologistorpathologyresident,participateintheexaminationandinterpretationof

biopsiesfromvariousbodysites.Theclerkwillalsohavetheopportunitytoparticipateinthegrossexaminationofsurgicalspecimenspertinenttothe

practiceofmedicine,forexample:colectomiesfromulceratedcolitis,thyroidectomiesforthyroidcancer,etc.Theclerkswillhavetheopportunitytofollow-

uponsomeoftheseresectionsbyreviewingtheirmicroscopicfindingsthefollowingday.Theywillalsobeencouragedtoparticipateintheexamination

offrozensectionsasrequired.Theclerkwillalsohavetheopportunitytoparticipateintheautopsyservice,theemphasisbeingonclinico-pathological

correlation.Inmostinstancestherewillbeampleopportunitytodiscusstheclinicalaspectsofsomeofthebiopsieswiththecliniciansandpathologistsasa

team.

Meds IV – Clinical Electives (Co-ordinators Dr. H. Ettler, Dr. A. Haig and Dr. K. Kwan)

TheDepartmentofPathologyoffersanoptioninClinicalAnatomicalPathologytoPhaseIVmedicalstudentsduringBlocksI,II,IIIandIVateachofthe

teachinghospitals.Thestudent/smayinitiallyobserveandlaterparticipateintheroutineactivitiesoftheClinicalDepartmentofPathology.Thestudent

willbeassignedtoastaffpathologistfordirectionandsupervision.Thesupervisorwillnegotiatewiththestudenttheterminalobjectivesoftherotationand

thestudent’slearninggoals.Itisalsopossibleforthestudenttoselectatopicofinterestforin-depthstudyduringthefourweekperiodrelatedtoaspecific

diseaseprocess,orspecificorgansystem,ordiagnosticprocedure,e.g.electronmicroscopy,immunohistochemistry,cytology,molecularpathology,etc.An

electiveinClinicalAnatomicalPathologyisviewedfavourablybyProgramDirectorsofvariousmedicalandsurgicaldisciplines.

Meds IV - Integration, Consolidation & Enrichment (ICE: Medicine 5402)

Primary Care Pathology Course (Course Coordinator Dr. B. Garcia)

Thiscourseismostsuitableforthoseconsideringacareerin:FamilyMedicine,InternalMedicine,Paediatrics,GynecologyandSurgery.Itwill,however,be

appropriateforpracticallyallmedicalcareerchoiceswiththeexceptionofresearchandadministration.

Attheendofthiscourse,thestudentswillbeableto:

•Developanappropriatestrategyfortheutilizationofthelaboratoryandpathologyservicesavailableintheircommunity.

•Obtainandpreparefordeliverytoalaboratorythevarioustypeofcytologicalsamples

•Interpretsurgicalpathologyandcytologyreportstoobtainthenecessaryinformationforproperpatientfeedbackandadvice.Largegroupsessions

centeredaroundoneormoreclinicalvignettesfollowedbyashortreviewofasubjectwithemphasison:currentissues,utilizationoflaboratory

services,outcomesandprognosis.WetworkshopssuchasFNAB(fineneedleaspirationbiopsies)willalsobeusedaswellasself-assessment

exercises.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

Syllabus and Course Structure: Dermatopathology,Laboratoryhematologyandhematopathology,GastrointestinalPathology,GeneralPrimaryCare

Issues(including,butnotlimitedto:breastlumps,FNAB,lumps/bumpsofheadandneck,clinicallaboratoryincludingrenalfunctionandurinalysis,prostate

cancer),Gynepathology(includingpapsmears),PediatricPathology,andCurrentissuesupdate

Forensic Medicine Course (Course Coordinator, Dr. M. Shkrum)

ForensicMedicineisaspecializedareaofMedicinewhichnotonlydealswithhowdiseasecausessuddendeath,butalsoexaminestheinjuriouseffects

ofvariousexternalagents(e.g.,firearms,poisons,blunttrauma,etc.)onthehumanbody.Thiscoursewilloutlinetopicsofpracticalimportanceandwillbe

givenbyexpertsinthevariousfieldsofinterest.Theopeninglecturewilldiscussdeathsrequiringnotificationofthecoroner.Thecoursewillconcludewith

theroleofamedicalexpertinthelegalsystem.

Objectives

•ToappreciatetheresponsibilitiesofaphysicianregardingtheCoroner’sActandbeinganexpertwitnessatinquestsandcivil/criminalproceedings.

•Todefinecauseandmannerofdeathandtoappreciatetheresponsibilitiesofaphysicianindeathcertification.

•Todifferentiatethegoalsofthemedicolegalvs.hospitalautopsy.

•Tounderstandhowsuddennaturalunexpecteddeathoccurs.

•Tolearnaboutvariousinjurytypesandmechanisms.

•Tolearnhowvariousdrugsandpoisonscanaffectthebody.

•Tounderstandtheassessmentandmanagementofinjuriesarisingfromdomesticviolenceandsexualassault.

•Toappreciatetheconceptofcontinuityofevidence.

Lectureformat.Setoflecturenotesprovided.ConjointlectureswillbeheldwiththeUndergraduatePathology4500Bcourse.

Topics: Coroner’sAct,Inquests(Medicolegal-HospitalAutopsies,Cause/MannerofDeath,DeathCertification),ThePhysicianasExpertWitnessinCivil

andCriminalProceedings,Identification,DeterminationofTimeofDeath,BluntTrauma-MotorVehicleRelatedDeaths(2hr);MotorVehicleCollision

Reconstruction,ForensicNeuropathology(CraniocerebralTrauma,SuddenNeurologicalDeath),ForensicPsychiatry,SharpForceInjuries,FirearmInjuries,

AsphyxiaandBurns,SexualAssault,ForensicToxicology(AlcoholandDrugsofAbuse),PediatricForensicPathology,SuddenNaturalUnexpectedDeath.


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

7.C3 – Undergraduate Dentistry

Dr. Mark Darling, Undergraduate Dentistry Chair

Withinthedentalschoolcurriculum,instructioningeneralandsystemicpathologyisintroducedinthefirstyear.Anumberof

coursesinoralpathologyarealsoofferedtoundergraduateandpostgraduatedentalstudents.

Dentistry 5162 - Systemic Pathology – Dr. J.A. Gomez, Course Coordinator

AcomponentoftheGeneralMedicineUnit,thissystems-basedcourserunssequentiallywithHumanPhysiology,Pharmacology,SystemicAnatomyand

Medicine.Thecourseexaminesspecificaspects(etiology,clinicalpresentation,macroscopicandmicroscopicfeatures,andpathogenesis)ofcommon

humandiseasesrelevanttothepracticeofdentistry.Taughttofirstyeardentalstudents.Lectures23hours.

Dentistry 5170 - Oral Diseases I – Drs. M. Darling and T. Daley – Course Coordinators

Anintegratedcoursecoveringthecommondiseasesoftheteeth,periodontalandperiapicaltissues;specificallycaries,gingivits,periodontitis,pulpdisease,

periapicalinflammation,regressivedentalconditionsanddentalanomalies.Taughttofirstyeardentalstudents.Lectures43hours;Labs1hour

Dentistry 5235 - Oral Diseases II – Drs. M. Darling and T. Daley – Course Coordinator

Thisintegratedcoursecombinesoralmedicine,oralpathologyandoralradiologytocoveravarietyofdiseasesthataffectthehardandsofttissuesofthe

mouth,headandneck.Taughttosecondyeardentalstudents.29lecturehours,5labhours,0clinichours(Total34hours)

Dentistry 5304 - Oral Pathology – Drs. M. Darling and T. Daley – Course Coordinator

Alecture/seminarcoursedealingwithclinical,microscopicandpathogenicaspectsofdiseasesof,oraffecting,themouth,faceandjaws.Studentswillbe

examinedonbasicoralpathologyaswellasmaterialtaughtinthiscourse.ThiscourseistaughttothirdyearDentistrystudents.

Internationally Trained Dentists – ITD5304 – Oral Pathology

ThiscourseisforthedentalstudentsintheQualifyingProgramandrunsfromSeptember–April.Theinstructorswillteachcommon,and/orimportant,and/

orsitespecificdiseasesoftheoralsofttissues,jaws,teethandrelatedstructures.59Lecturehours.


SEC

TIO

N 7

– E

DU

CAT

ION

PR

OG

RA

MS

7.D – Update on Professional & Education Development

Dr. Keith Kwan, Continuing Professional Development

TheDepartmentofPathologyProfessionalDevelopmentCommitteecoordinatesavarietyofgeneralandsubspecialtypathology

rounds,andassistsinaccreditationoftheseroundswiththeRoyalCollege.PathologyGrandRoundsoccuronamonthly

basisduringtheacademicyear(OctobertoMay),bringinginspeakersfromavarietyofcentersanddisciplines,andarehighly

regardedbyourattendees.Ourweekly“interestingcase”roundsandnumeroussubspecialtyroundsprovideanexcellent

learningopportunityforourresidentsandstaff.

EffortsoftheProfessionalDevelopmentCommitteearecurrentlybeingcenteredontheimplementationofvideoteleconferencingtechnologiesinour

conferenceroom,inordertoexpandthereachofoureducationalopportunitiestoourcommunityhospitalcolleagues,aswellastostafflocatedatsatellite

officesthroughoutLondon.

Date Speaker TopicOct13,2010 Dr.ManalGabril

DepartmentofPathology“InformaticsforPracticingAnatomicalPathologists:

MarkingaNewErainPathologyPractice.”

November10,2010 Dr.MarkVincentDepartmentofOncology

“TheimportanceofsubtypinginadvancedNSCLC.”

December8,2010 Cancelledduetoweather

January12,2011 Dr.MichaelShkrumandElenaTugalevaDepartmentofPathology

“ForensicPathologyinForeignLands.”

February9,2011 Dr.ClaireTempleDepartmentofSurgery

“ManagingintransitMelanomaMetastases.”

April13,2011 Dr.BerthaGarciaDepartmentofPathology

“TheYemenExperience!”

May11,2011 Drs.C.M.McLachlin,M.WeirandH.EttlerDepartmentofPathology

“AReviewofQualityInitiativesinPathologyatLHSCandinOntario.”

Professional Development Committee (CME)

Nofixedterm,appointedbyChair

Dr.SubrataChakrabarti

Dr.KeithKwan,Chair

Dr.DavidRamsay

Dr.NancyChan

Dr.ChrisArmstrong

Dr.MariammaJoseph

MairHughes(Ex-officio–AdministrativeOfficer)

2010-2011 Pathology Grand Rounds


SECTIO

N 7 – ED

UC

ATION

PRO

GR

AM

S

7.E – Expanding our Educational Reach in the Region and Around the World

Dr.Chakrabartiisanexaminerofinternationalgraduateprograms(MScandPhD)atGujratUniversity,CalcuttaUniversity,Indiaandhasbeenagraduate

programreviewerofpathologyatKuwaitUniversity,Kuwait.

InYemen,Dr.GarciaisanadvisortothePresidentofYementhroughtheCanadianMedicalDelegationandassuch,shehasdoneanauditofthe

UndergraduateMedicalProgramsattheUniversityofScienceandTechnology(UST),TheUniversityofSana’aandtheUniversityofAden.Sheiscurrently

engagedinanadvisorycapacityinthepreparationoftheUSTforAccreditationthroughtheArabBoardandtheWHO(WorldAssociationofFacultiesof

Medicine).Dr.GarciaiscurrentlyontheOrganizingCommitteeoftheHealthProfessionsEducationAccreditationConference.

TheSchulichSchoolofMedicine&DentistryrecentlylaunchedadualPhDprogramwithWesternChinaUniversityandthefirstrecruitofthisinitiative,

Dr.ShuhuaLuo,arrivedthisfallfromChengdu,China.SeveralfacultymemberstraveleachyeartoteachPathologytomedicalstudentsatSt.George’s

UniversityMedicalSchoolinGrenada.InthepastyearDr.RamsayhaslecturedattheUniversityofMalagainSpain.

Dr.BendisamemberoftheIDRC-fundedresearchprojectconcerningthesustainabilityandpublichealthofLakeNaivashainKenyathatisbeingpursued

betweenaninterdisciplinaryteamofresearchersledbyProfessorCharlesTrick,theIveyChairinEcosystemHealthatSchulichMedicine&Dentistryand

theFacultyofScienceatWesternandProfessorWilliamShivogaoftheFacultyofEnvironmentalSciences,EgertonUniversity,Kenya.

Fromtheclinicalandhumanitarianpointofview,severalofourpathologistsprovidepro-bonoconsultationserviceswithhealthinstitutionsinSouth

America,MiddleEast,AfricaandAsia.Dr.E.TugalevawasCanadianrepresentativeintheDisasterVictimIdentificationInterpolmissionfollowingtheHaiti

earthquake.Dr.GarciahasbeenanactivememberofPAMS(PeruvianAmericanMedicalSociety)andhasparticipatedinshort-termmedicalmissionstothe

AndesofPeruforthepast15years.Sheisalsoamemberofanon-for-profitorganization:PathologistsOverseas,whoseektotrainpathologistsingreatly

underservicedareasoftheworld(mostlyAfrica)byproviding“onsite”residencytrainingtolocalphysiciansthroughaninternationalcadreofvolunteer

pathologyeducators.

Since1993,Dr.MJosephhasservedasaConsultantPathologist(probono)totheRegionalCancerCenterinKerala,India.Dr.JosephgivesyearlyCME

symposia,workshopsandlecturestothepathologistsintheKeralaregionofIndia.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

Section 8 – Research

8.A – The Department of Pathology Research Report 2010-11

Director of Research, Dr. J. Bend

Overview

TheresearchersintheDepartmentofPathologyhavecontinuedtomaintainandgrowtheirrespectiveresearchprograms.The

Departmenthasmademajorinroadsinitsplanstoenhanceitsresearchcapacity,capability,productivityandimpact.Tothiseffect,theDepartmenthasbeen

abletoincreaseitsfacultycomplement(bothbasicandclinicalresearchers),developasignificantlylargerandmorecomprehensivegraduateprogramwith

asmallcorebutveryproductiveresearchfacultyandcross-appointeesinbothBasicScienceandClinicalDepartmentsinSchulich,andintheFacultiesof

ScienceandSocialScience.Atarecentretreat,Departmentmembersmadeacommitmenttofosterfurthergrowthinresearch.

TheSchulichSchoolofMedicine&Dentistryhasidentifiedseveralareasofresearchexcellenceincluding:Cancer;HeartDisease;VascularBiologyand

Respiration;Maternal/Fetal,ChildandFamilyHealth;NeuroscienceandMentalHealth;MusculoskeletalHealth;andTransplantation,Immunology,Infectious

DiseasesandDiabetes.Aswillbeevidentfromthefollowingdiscussion,researchersfromtheDepartmentofPathologyareactiveparticipantsinmanyof

theseareas.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

Scope of our research

MembersofPathologyareacriticalcomponentofmanyofSchulich’sresearchprogramsandinitiatives.Ourfacultymembershaveplayedandcontinueto

playleadingrolesinsomeoftheresearchareasofrecognizedexcellence,andacollaborativeroleinothers.Membersofourdepartmentcollaboratewith

investigatorsfromtheRobartsResearchInstitute,LawsonHealthResearchInstitute,andtheLondonRegionalCancerInstitutewithinSchulichandwith

otherFacultiesatWestern.

Departmental Research Programs

ResearchinPathologyincludesbothinvestigator-drivenresearch,initiatedbythecoremembersofthedepartment,andcollaborativeresearchwith

membersofotherdepartments.MembersoftheDepartmentofPathologyareinvolvedwith,andarekeyplayersinalmosteverysignatureprogramofthe

SchulichSchoolofMedicine&Dentistry.ListedbelowareafewspecificresearchprogramsinwhichtheDepartmentofPathologyisplayingamajorrole.

Transplant research

Researchintransplantation(clinicalandexperimental)isoneofourDepartment’sfocusareas,andhasdemonstratedstronggrowthduringthelastyear.

ThebackboneofthexenotransplantprogramistheexpertiseofpeoplesuchasDrs.BerthaGarcia,DavidWhiteandWeipingMin(crossappointeesfrom

Surgery),andZhu-XuZhang(crossappointeefromMedicine).

Dr.GarciaistheDirectorofthecorelaboratoryoftheMulti-OrganTransplantProgram’s(MOTP)experimentalarmwhichresidesinPathology.Thisgroup

ofresearchersisfundedfromCIHR,HSFO,MOTP,NIH,andothernationalandinternationalorganizations.Researchinthisfieldhasbeenveryproductive

withalargenumberofpublicationsinhighimpactjournals.

Cancer research

TheDepartmentofPathologyhasastrongpresenceinthefieldofcancerresearchinboththeexperimentalandclinicalareas.Thekeyresearchersinthis

areaareDrs.ChandanChakraborty,JoanKnoll,AlanTuckandAnnChambers(cross-appointeefromOncology)(BreastCancer);MadeleineMoussaand

JoseGomez(ProstateCancer);KamiliaRizkalla(HematologicMalignancies);DavidDrimanandJeremyParfitt(GIandHepatobiliaryCancer);Mariamma

Joseph(SkinandPulmonaryCancers);MegMcLachlanandMicheleWeir(GynecologicalCancers);BretWehrli(SoftTissueTumors);LeeCynAngand

RobertHammond(NeurologicalCancer);andThomasDaleyandMarkDarling(OralCancers).

TheresearchersinthisareahavereceivedtheirfundingfromCIHR,CBCF,ORFandothernationalandinternationalorganizations.Severalpathologistsare

alsoheavilyinvolvedinclinicaltrials.Departmentmemberscontinuetoproducehighqualitypublicationsinbasic,clinicalandtranslationalaspectsofcancer

research.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

Vascular biology research

Vascularbiologyresearchershavefocusedtheirattentiononchroniccomplicationsofdiabetes(Dr.SubrataChakrabarti),cardiovascular(Dr.TianqingPeng)

andstemcellresearch(Dr.ZiaKhan).ThisresearchhascontinuedtoreceivefundingfromCIHR,CDAandHSFO.Withinthisresearchprogramaclose

interactionhasbeenestablishedwithDr.ChandanChakrabortywithrespecttosignaltransduction.

TherecentrecruitmentofDr.ZiaKhanandappointmentofDr.EdithAranytoourdepartmenthavefurtherexpandedthescopeofvascularbiologyresearch.

Dr.Khan’sprogramisfocusedonendothelialprogenitor(stemcells)andtheirroleindiabeticcomplicationsandinvasculartumours.Sincebeingappointed

asanAssistantProfessor,Dr.KhanhasreceivedfundingfromCIHRandCDAaswellasLHRI.Dr.Aranyisinvolvedindelineatingthemechanismsofislet

developmentinthepancreas.

Environmental pathology research

Itisnowobviousthatoxidativestressanditscloselyrelatedcousin,nitrosativestress,playsignificantrolesintheinitiationand/ortheprogressionof

manychronicdiseases.Pathologyhasalargenumberofresearcherswhoareinvolvedinenvironmentalpathologyresearchandhasestablisheda

graduateprograminecosystemhealth.ThisgrouphasmembersfromseveraldepartmentsincludingtheDepartmentsofClinicalNeurologicalSciences

(JorgeBurneo);FamilyMedicine(CarolHerbert,AmardeepThind);Pediatrics(MichaelRieder,GideonKoren[IveyChairinMolecularToxicology],and

theFacultiesofScience(IrenaCreed,Biology;CharlieTrick,Biology[IveyChairinEcosystemHealth])andSocialScience(BradleyCorbett,Sociology

[StatisticsCanada];RegnaDarnell,Anthropology).ThesenewadditionstothePathologyGraduateProgramcomplementexistingresearchexpertiseinthe

Department(JackBend,SubrataChakrabarti,ChandanChakraborty,BerthaGarciaandRobHammond).Theresearcheffortshavereceivedfundingfrom

AssemblyofFirstNations-HealthCanadaEnvironmentalContaminantsProgram,theAssociationofUniversitiesandCollegesofCanada,UWOinternational

curriculumfundsandtheIDRC.

Genetics research

Thedepartmenthasbeensuccessfulinrecruitingandrepatriatingahighlyqualifiedandseasonedresearcherinmolecularpathologyandcytogeneticsfrom

theUSA(Dr.JoanKnoll).Dr.KnollhasalreadyreceivedCFIfundingfortranslationalmolecular/molecularcytogeneticsresearchinfrastructureandhas

graduatedherfirstMScstudentinPathology.Thiswillfurtherincreaseourresearchactivityinthisarea.

Research in Education

Educationresearchisalsoalargepartofourfacultycommitment.Ourfacultymemberscontinuetoplaykeyrolesinthedevelopmentofinnovativeresearch

methodologiesandimplementthematalllevelsofeducation.Drs.BerthaGarciaandCandaceGibsonareleadersatSchulichinthisarea.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

Others

Asmentionedearlier,theareasaboverepresentsomeoftheresearchactivityandexpertiseoftheDepartment.Alargeamountofcollaborativeresearch

occurswithinPathologyandwithotherbasicandclinicaldepartmentsatSchulichwhichisdependentupontheactive,keyparticipationofourdepartmental

members.

Faculty research interests:

Adams*:Hemochromatosis,liverdiseases

Ang: Neurodegenerativeandneurotoxicdiseases,CNStumours

Arany:Diabetes,mechanismsofisletdevelopment

Bend: Mechanismsoftoxicityofendogenousandexogenouschemicals,oxidativestress,attenuationofadversedrugreactions;environmental

toxicologyinFirstNationsandatLakeNaivasha,Kenya

Chakrabarti: Chronicdiabeticcomplications,diabeticretinopathy,diabeticcardiomyopathy,extracellularmatrixproteins,epigenetics,naturalproducts

Chakraborty:Intrauterinegrowthretardation(IUGR),preeclampsia,tumourprogression,cellmigration/invasion,cellsignalling

Chambers*: Molecularoncology,mechanismsoftumourprogressionandmetastasis

Daley: Oralpathology,salivaryglandresearch,clinicalresearch

Darling: Oralpathology,salivaryglandresearch,clinicalresearch,salivaryglandneoplasia,mucocutaneousdiseases

Driman: Gastrointestinal,hepaticandpancreaticobiliarypathology

Garcia: Transplantation,animalmodels,ecosystemhealthinSouthAmerica

Gibson: Neurochemicalpathology,CNSageing&neurodegenerationtransmitterrelease;researchincommunicationsandeducation

Hammond: Cerebrovasculardisease,braindevelopment,highfieldMRI/neuropathologycorrelates,neuroinflammation,neuromusculardisease,

braintumourbiology

Karlik*:Multiplesclerosis,experimentalallergicencephalomyelitis,apoptosis,chemokinesignalling,integrin-mediatedneuroinflammation,

spinalcordtrauma

Khan: Vascularstemcells,vasculogenesis,angiogenesis,endothelialcells,perivascularcells,diabetes,cancer,extracellularmatrix

Knoll: Molecularcytogenetics,medicalgenetics,molecularandcancergenetics,genomics,bioinformatics

Koropatnick*: Metallothioneinandresistancetoradiationandchemotherapeuticdrugtreatment;siRNAtherapy

McLachlin: Cervicalcancerscreening,HPV

Min*: Immunomudulation,transplanttolerance,genesilencing,siRNAtherapy

Peng*: Cardiovasculardisease,heartfailure


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

Strong*: Motorneurondisease,neurofilamentmetabolism,aluminumneurotoxicity

Tuck: Breastcancer,metastasis,progression,cellandmolecularbiology,translationalresearch

Wang*: Immunomodulation,transplantrejection,xenotransplantation

Zheng*: Immunomodulation,transplantrejection,

(*=indicatescrossappointees)

Summary Publication Data (July 1, 2010 to June 30, 2011)

Published Peer reviewed journal articles

Published Books & Book

Chapters

Published Abstracts

Published Case Reports Totals

MD/CTA 47 1 16 2 66PhD/Scientists 9 5 4 0 18Totals: 56 6 20 2 84

Invited LecturesNational

Invited Lectures

International

Abstracts & Posters National

Abstracts & Posters

InternationalTotals

MD/CTA 20 8 21 20 69PhD/Scientists 3 0 5 4 12Totals: 23 8 26 24 81

Summary Invited Scientific Lectures and Presentations (July 1, 2010 to June 30, 2011)

# Awards Total Award 2010-11 FundingExternally Funded – PI 23 $5,156,599 $1,627,109Externally Funded – Co-Inv 17 $9,612,158 $2,498,244Internally Funded – PI 18 $192,176 $134,714Internally Funded – Co-Inv 3 $150,000 $115,000

Total Grant Funding: $15,110,933 $4,375,067

Summary New Grant Funding Data (July 1, 2010 to June 30, 2011)


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

Postdoctoral Fellows, Postdoctoral Associates, Visiting Scientists

Dr.Biao(Francis)Feng(Dr.Chakrabarti)-pathogeneticmechanismsofchronicdiabeticcomplications

Dr.SubhrojitSen(Dr.Chakrabarti)–Effectsofginsengonchronicdiabeticcomplications

Dr.LinboZhang(Dr.Chakrabarti)–FGFinchronicdiabetescomplications

Robert Zhong Research Seminars – Dr. David Driman, Coordinator

In2006theDepartmentofPathologyResearchCommitteeinitiatedamonthlyresearchseminar,namedafterDrRobert(Zheng)Zhong,withthepurposeof

capturingtheresearchinterestsofourdepartmentandthewideruniversityandhospitalcommunity.Theobjectivesaretoenhanceourdepartmentalbasic

andclinicalscienceresearch,andtoimprovecommunicationwithinthedepartmentandbetweendepartmentalmembersandotherresearchersinthecity.It

isanimportantforumforresearchstaffandfacultytopresenttheirwork,getfeedbackontheirresearchfromthewholegroup,andstimulatenewideasand

initiatecollaboration.Theseseminarsarefocusedonabroadaudienceincludingbasicscientists,pathologists,clinicians,residentsandgraduatestudents.

TheseminarsareaccreditedbytheRoyalCollege,MaintenanceofCertificationprogram.

2010-2011 Zhong Research Seminars

Date Speaker TopicOctober7,2010 Dr. David White, PhD, FRCP–ProfessorofSurgery&PathologyDirector/Scientist,Transplantation&

Pathology,SchulichSchoolofMedicine“ANovelTechniqueforIsletTransplantationwhichisIsletSparing”

November4,2010 Dr. Guido Filler, MD, PhD, FRCPC–ProfessorofPaediatrics&Chair/Chief,DepartmentofPaediatricsChildren’sHospital,LHSC&SchulichSchoolofMedicine&Dentistry

“TheBarkerHypothesisandBeyond,orwhatdoestheBattleofArnhemhavetodowithobesityandhypertension?”

February3,2011 Dr. J. Michael Strong, MD, FRCP, FANN, FCAHS–Dean,SchulichSchoolofMedicine&DentistryCrossAppointment&AdjunctProfessorScientist,MolecularBrainResearchGroup

“PathogenesisofCognitiveImpairmentinALS”

April7,2011 Dr. Anthony M. Jevnikar, M.Sc., MD, FRCP–Professor,DepartmentofMedicine,Co-Director,MultiOrganTransplantProgram,LHSC

“InnovationinImmunosuppression–WhatAretheNewTargets”

June2,2011 Dr. J. Q. Madrenas, MD PhD–CanadianResearchChairinImmunobiology,Professor,Microbiology&ImmunologyandMedicine,HeadofImmunology,RobartsResearchInstitute,AssociateDirector,CentreforHumanImmunology

“SlipinBeauty:AwakeningMitochondrialFunctionwithSLP2”

Building of research infrastructure

ThePathologyDepartmentcontinuestoprovideasignificantamountofresearchinfrastructurewhichisfrequentlyorganizedascorefacilitiesatLHSCor

UWOtofacilitateresearchofinvestigatorsinLondon.Itisourgoaltosupportasmanyresearchersaspossiblewiththisinfrastructure.

1)Tissuepreparationfacility–UH

2)Transplanthistologylab

3)TissueandArchives

4)OICRtissuecollection

5)Morphometrycore

6)Real-timePCRcore

7)PalmLaserDissection

8)SharedMultimediAResourceand

TeachingCentre(SMART)Centre


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

2011 Annual Pathology Research Day – Dr. Alan Tuck, Coordinator

PathologyResearchDayisanannualeventorganizedtorecognizeresearchexcellenceandpromotecollaboration,targetingourclinicalandbasicscience

facultymembers,residents,postdoctoralandclinicalfellows,MScandPhDstudentsandtechnicalstaff.Thisfulldayeventallowsourtraineestopresent

theirresearchinoralpresentationsandpostersessions.

PathologyResearchDay2011tookplaceonTuesday,May3rdandwasagreatsuccess.GuestspeakerDr.TorstenNielsen,AssociateProfessorand

clinician-scientistintheDepartmentofPathologyandLabratoryMedicineatUBC,presentedhistalkentitled:“ResidentResearchProjecttoClinicalTrail:

A10YearJourney”.

2011 Research Day Awards

•Chair’sAwardforBestPresentationbyaResident-Dr. Hector Li

•SecondPlaceAwardforBestPresentationbyaResident-Dr. Mara Cargea

•Dr.M.DariaHaustAwardforBestPresentationbyaGraduateStudent-Andrew Pepper

•SecondPlaceAwardforGraduateStudents-Jamie Belo

•PosterPresentationAwardforaGraduateStudents-Jessica Dubrick

•Dr.CameronWallaceGraduateStudentAwardinPathology-Yuexiu Wu

Challenges Ahead

Pathologyhascontinuedtomakeexcellentprogressinresearchduringthelastyear,howeverthisgrowthofresearchpotentialislimitedbytheshortageof

highqualitywetlaboratoryresearchspaceandadequatespaceforcorefacilities.Asindicatedbefore,thesearetrulysuccessstories.However,thereare

risksinvolvedwhenthenewrecruitsfindthemselvestryingtooperateinsubstandardfacilitiesandinadequateresearchspace.Anotherchallengeforall

investigatorsisthedecreaseinavailableresearchfunds(duetodifficulteconomictimes)thatalsoimpactnegativelyonourresearchendeavors.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

8.B – Publications, Book Chapters and Abstracts

Journal Articles Published (July 1, 2010 to June 30, 2011)

1. SyJ,AlturkustaniM,Ang LC.Intracallosallongitudinalfiberbundle:anunexpectedfindingmimickingdemyelinationinapatientwithTurner syndrome.ActaNeuropathol.2010Oct;120(4):545-7.Epub2010Jul23.

2. JiangYJ,Ang LC,BlumeWT.ExtentofEEGepileptiformpatterndistributionin"focal"corticaldysplasiaJClinNeurophysiol.2010Oct;27(5):309-11

3. FangL,DengZ,ShatsevaT,YangJ,PengC,DuWW,YeeAJ,Ang LC,HeC,ShanSW,YangBB.MicroRNAmiR-93promotestumorgrowthand angiogenesisbytargetingintegrin-β8Oncogene.2011Feb17;30(7):806-21.Epub2010Oct18.

4. SyJ,Ang LC.Cytomorphologicspectrumofmixedpituitaryadenoma-gangliocytomas:areportoftwocases.ActaCytol.2010Sep-Oct;54 (5Suppl):981-4

5. HajiFA,PatelYK,Ang LC,MegyesiJF.Acaseofmistakenidentity:spinalepiduralangiolipoma.CanJNeurolSci.2011Mar;38(2):357-9 6. KorenG,Bend JR.Fishconsumptioninpregnancyandfetalrisksofmethylmercury.CanFamPhysician.56(10):1001-1002,2010.

7. ElzagallaaiAA,Garcia-BournissenF,FinkelsteinY,Bend JR,RiederMJ,KorenG.Severebulloushypersensitivityreactionsafterexposureto carbamazepineinaHanChinesechildwithapositiveHLA-B*1502andanegativelymphocytetoxicityassay:Evidencefordifferent pathophysiologicalmechanisms.JPopulationTherClinPharmacol.18(1):e1-9,2011.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

8. RaiA,Al-JaradiM,BurnierM,Chakrabarti S.CongenitalchoroidalmelanomainaninfantCanJOphthalmol.2011Apr;46(2):203-4.

9. YueD,BrintnellW,MannikLA,ChristieDA,HaeryfarSM,MadrenasJ,Chakrabarti S,BellDA,CairnsE.CTLA-4Igblocksthedevelopmentand progressionofcitrullinatedfibrinogen-inducedarthritisinDR4-transgenicmice.ArthritisRheum.2010Oct;62(10):2941-52.

10. McArthurK,FengB,WuYX,ChenS,Chakrabarti S.MicroRNA-200bregulatesvascularendothelialgrowthfactor-mediatedalterationsindiabetic retinopathyDiabetes.2011Apr;60(4):1314-23.Epub2011Feb28

11. FrancisSM,Chakrabarti S,DickFA.Acontext-specificroleforretinoblastomaprotein-dependentnegativegrowthcontrolinsuppressingmammary tumorigenesis.PLoSOne.2011Feb22;6(2):e16434.

12. ZuoY,WuY,Chakraborty C.Cdc42negativelyregulatesintrinsicmigrationofhighlyaggressivebreastcancercells.JCellPhysiol.2011May26. doi:10.1002/jcp.22853.[Epubaheadofprint]

13. Darling MR,KutalowskiM,MaccphersonDG,Jackson-BoetersL,WysockiGP.OralElastofibromatousLesions:AReviewandCaseSeries.Head NeckPathol.2011Jun18.[Epubaheadofprint]

14. Daley T, Darling MR.Metastasestothemouthandjaws:acontemporaryCanadianexperience.JCanDentAssoc.2011Jun;77:b67.

15. Daley TD,MinettCP,Driman DK, Darling MR.Oralmetastatichepatocellularcarcinoma:achangingdemographicinEuropeandNorthAmerica. Immunohistochemicaladvancesinthemicroscopicdiagnosis.OralOncol.2011Jan;47(1):62-7.Epub2010Aug21.

16. Darling MR, Wehrli B,ZeligmanE,SmillieJ,Daley T.UnusualBenignSmoothMuscleLesionsoftheTongue:ReviewandReportofTwoCases. HeadNeckPathol.2010Nov30.[Epubaheadofprint].

17. Driman DK,NhanC,RabyM,SmithAJ,HunterA,SrigleyJ,McLeodRS.RectalCancerPathologyReportinginOntario:Acontemporaryauditof marginandlymphnodeassessmentCanJPathol2011;3:21-25

18. ShahidS,FraserDD,Driman DK,BaxKC.Severehypernatremicdehydrationandmetabolicacidosisduetoneonatalintestinalmicrovillus inclusiondisease.Neonatology101(2):154-158

19. AlAmeelT,Driman DK,Reynolds,RP.Amiddle-agedwomanwithpersistentgastrointestinalbleedSaudiJGastroenterol.2011May- Jun;17(3):218-9.

20. Mendez-ProbstCE,ErdeljanP,CastonguayM,Gabril M, Wehrli B,RazviH.Myxoidchondrosarcomaofthescrotum:acasereportandreviewof theliterature.CanUrolAssocJ.2010Aug;4(4):E109-11.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

21. JollyUS,ShihA,MoistL,ClarkW,Gabril M.InfluenzaAH1N1,microscopicpolyangiitisandpulmonaryhaemorrhageNephrology(Carlton).2010 Dec;15(8):781.doi:10.1111/j.1440-1797.2010.01375.x.

22. WangS,ZhangZX,YinZ,LiuW,Garcia B,HuangX,AcottP,JevnikarAM.Anti-IL-2receptorantibodydecreasescytokine-inducedapoptosisof humanrenaltubularepithelialcells(TEC).NephrolDialTransplant.2011Jul;26(7):2144-53.Epub2010Dec2.

23. ZhangZX,LianD,HuangX,WangS,SunH,LiuW,Garcia B,MinWP,JevnikarAM.AdoptivetransferofDNTcellsinduceslong-termcardiac allograftsurvivalandaugmentsrecipientCD4(+)Foxp3(+)Tregcellaccumulation.TransplImmunol.2011Jan15;24(2):119-26.Epub2010Nov9.

24. DengJ,LianD,Garcia B,JevnikarA,WangH,LukeP.DonorpreconditioningwithCORM-2protectsagainstischemia-reperfusioninjuryinkidney transplantation.KidneyInternational2011May;79(10):1080-9.Epub2011Jan26.

25. GeW,JiangJ,ArpJ,LiuW,Garcia B,WangH.RegulatroryT-cellGenerationandKidneyAllograftToleranceInducedbyMesenchymalStemCells AssociatedwtihIndoleamine2,3-DioxygenaseExpression.Transplantation.2010Dec27;90(12):1312-20.

26. LanZ,GeW,AprJ,JiangJ,LiuW,GordonD,HealeyD,DeBenedetteM,NicoletteC, Garcia B,WangH.InductionofKidneyAllograftTolerance bySolubleCD83AssociatedwithPrevalenceofTolerogenicDendriticCellsandIndoleamine2,3-Dioxygenase.Transplantation.2010Dec 27;90(12):1286-93.

27. GeW,ArpJ,LianD,LiuW,BarojaL,JiangJ,RamcharranS,ZahrElDeenF,ZinserE,SteinkassererA,ChouP,BrandS,NicoletteC,Garcia B, WangH.ImmunosuppressionInvolvingSoluableCD83InducesTolerogenicDendriticCellsThatPreventCardiacAllograftRejection. Transplantation.2010Dec15;90(11):1145-56.

28. GeW,JiangJ,LiuW,SaitoA,Garcia B,LiXC,WangH.RegulatoryTcellsarecriticaltotoleranceinductioninpresensitizedtransplantrecipients throughtargetingmemoryTcells.AmJTransplant.2010Aug;10(8):1760-73.Epub2010Jul15

29. ZhangZX,ShekK,WangS,HuangX,LauA,YinZ,SunH,LiuW,Garcia B,RittlingS,JevnikarAM.Osteopontinexpressedintubularepithelial cellsregulatesNKcell-mediatedkidneyischemiareperfusioninjury.JImmunol.2010Jul15;185(2):967-73.Epub2010Jun14.

30. ChanSM,Gomez-Lemus JA.Malignantmixedgermcelltumourina13-year-oldboywithfamilialtestotoxicosis.CanJPathol2011 Spring;3(1):25-26.

31. LauP,LiChangHH, Gomez JA,ErdeljanP,SrigleyJR,IzawaJI.Ararecaseofcarcinomacuniculatumofthepenisina55-year-old.CanUrol AssocJ2010Oct;4(5):E129-32.

32. RaghigH,BryanYoungG,Hammond RR,NicolleM.AcomparisonofEMGandmusclebiopsyinICUweakness.NeurocritCare.2010 Dec;13(3):326-30.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

33. HajiF,AlturkustaniM,ParrentA,MegyesiJ,GulkaI,Hammond RR.Simplepartialseizuresina70-year-oldfemale.CanJNeurolSci.2011 May;38(3):507-11. 34. MirsattariSM,ChongJJ,Hammond RR,MegyesiJF,MacdonaldDR,LeeDH,CairncrossJG.Doepilepticseizurespredictoutcomeinpatients witholigodendroglioma?EpilepsyRes.2011Mar;94(1-2):39-44

35. MeyerM,Keith-RokoshJ,ReddyH,MegyesiJ,Hammond RR.SourcesoferrorinneuropathologyintraoperativediagnosisCanJNeurolSci. 2010Sep;37(5):620-4.

36. ChaudharyN,HuA,RotenbergBW,DuggalN,Howlett CJ, Hammond RR,ParnesL,LownieSP.Stagedtranscrusalandtranssphenoidal endoscopicresectionofanatypicalclivalmelanoma:acasereportandliteraturereview.SkullBase.2010Sep;20(5):349-55.

37. NicholKA,AdamHJ,Hussain Z,MulveyMR,McCrackenM,MatasejeLF,ThompsonK,KostS,Lagacé-WiensPR,HobanDJ,ZhanelGG; CanadianAntimicrobialResistanceAlliance(CARA).Comparisonofcommunity-associatedandhealthcare-associatedmethicillin-resistant StaphylococcusaureusinCanada:ResultsoftheCANWARD2007-2009Study.DiagnMicrobiolInfectDis.2011Mar;69(3):320-5.

38. StuartJI,John MA,MilburnS,DiagreD,WilsonB,Hussain Z.Susceptibilitypatternsofcoagulase-negativestaphylococcitoseveralnewer antimicrobialagentsincomparisonwithvancomycinandoxacillin.IntJAntimicrobAgents.2011Mar;37(3):248-252.Epub2011Feb4/

39. WalkerMG,YaoLJ,PattersonEK,Joseph MG,CepinskasG,VeldhuizenRA,LewisJF,YamashitaCM.Theeffectoftidalvolumeonsystemic inflammationinAcid-inducedlunginjury.Respiration.2011;81(4):333-42.Epub2011Feb9.

40. BoydK,HendersonC,Joseph M,YardleyN,TempleC.Obtaininghighcureratesforchallengingfacialmalignancies:Anewmethodforproducing rapid,accurate,high-qualityfrozensectionsCanadianJournalofPlasticSurgerySpring2011,Volume19Issue1:22-26

41. WalkerMG,YaoLJ,PattersonE,Joseph MG,CepinskasG,VeldhuizenRA,LewisJF,YamashitaCM.Theeffectoftidalvolumeonsystemic inflammationinAcid-inducedlunginjury.Respiration.2011;81(4):333-42.Epub2011Feb9.

42. MoukarbelRV,Kwan K,FungK.LaryngealEpithelial-myoepithelialCarcinomaTreatedwithPartialLaryngectomyJOtolaryngolHeadNeckSurg. 2010Oct;39(5):E39-41

43. ChalasaniV,MartinezCH,WilliamsAK, Kwan K,ChinJL.Histologicalchangesinthehumanprostateafterradiotherapyandsalvagehighintensity focusedultrasound.CanUrolAssocJ.2010Aug;4(4):E100-2.

44. KanL,VanTilL,DeckerK,MacIssacM,McLachlin CM,LotockiR,OnyskoJ,O'DonnellS,ShuklaN.Executivesummary--performance monitoringforcervicalcancerscreeningprogramsinCanada.ChronicDisCan.2010Dec;31(1)45.

45. ChinCJ,FranklinJH,Moussa M,ChinJL.Metastasisofrenalcellcarcinomatothethyroid12yearsafternephrectomy.CMAJ.2011Jan17. [Epubaheadofprint]


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

46. ChanSM,GarciaFJ,ChinJL,Moussa M,GabrilMY.Theclinicalsignificanceofin-depthpathologicalassessmentofextraprostaticextensionand marginstatusinradicalprostatectomiesforprostatecancerProstateCancerProstaticDis.2011Apr19.[Epubaheadofprint].

47. SeyMSL,Parfitt JR,GregorJ.ProspectivestudyofclinicalandhistologicalsafetyofpureanduncontaminatedCanadianoatsinthemanagement ofceliacdisease.JParenterEnteralNutr.2011Jul;35(4):459-64.Epub2011May31.

48. AlbionC,Shkrum MJ,CairnsJ.Contributingfactorstomethadone-relateddeathsinOntario.AmJForensicMedPathol.2010Dec;31(4):313-9

49. Shkrum MJ.Editorial:TheBenefitsofanAutopsy.CanadianJournalofPathologyVolume2,Issue4,Winter2010

50. SouterLH,AndrewsJD,ZhangG,CookAC,PostenkaCO,Al-KatibW,LeongHS,RodenhiserDI,ChambersAF,Tuck AB.Human21Tbreast epithelialcelllinesmimicbreastcancerprogressioninvivoandinvitroandshowstage-specificgeneexpressionpatterns.LabInvest.2010 Aug;90(8):1247-58.Epub2010May10

51. AnborghPH,MutrieJC,Tuck AB,ChambersAF.Roleofthemetastasis-promotingproteinosteopontininthetumourmicroenvironment.JCellMol Med.2010Aug;14(8):2037-44.doi:10.1111/j.1582-4934.2010.01115.x.Epub2010Jul1.

52. GouletB,KennetteW,AblackA,PostenkaCO,HagueN,MymrykJS,GiguereV,Tuck AB,ChambersAF,LewisJD.NuclearlocalizationofMaspin isessentialforitsinhibitionoftumourgrowthandmetastasisLabInvest.2011Aug;91(8):1181-7.doi:10.1038/labinvest.2011.66.Epub2011Apr18.

53. AnborghPH,MutrieJC,Tuck AB,Chambers.AFPre-andpost-translationalregulationofosteopontinincancer.JCellCommunSignal.2011 Jun;5(2):111-22.Epub2011Apr26.

54. CardS, Tweedie EJ, Shkrum MJ.ACaseofVascularEhlers-DanlosSyndromePresentingatAutopsy.CanadianJournalofPathology2010;2 (3):9-11

55. Xu J,SiuVM.IsthereacorrelationbetweentheproportionofcellswithisodicentricYpatamniocentesisandphenotypicsex?PrenatDiagn.2010 Sep;30(9):839-44.

56. DawsonAJ,ChernosJ,McGowan-JordanJ,LavoieJ,ShettyS,SteinrathsM,WangJC,Xu J.CanadianCollegeofMedicalGeneticists committees.CCMGguidelines:prenatalandpostnataldiagnostictestingforuniparentaldisomy.ClinGenet.2011Feb;79(2):118-24.doi: 10.1111/j.1399-0004.2010.01547.x.Epub2010Oct12.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

Abstracts Published (July 1, 2010 to June 30, 2011)

1. WangC,GeorgeB,ChenS,FengB,Chakrabarti S.GenotoxicstressandactivationofnovelDNArepairenzymesintheendothelialcellsandin theretinaindiabetes.Diabetes59(suppl1):A269,2010

2. FengB,ChenS,McArthurK,WuY,Chakrabarti S.IntravitrealdeliveryofmiR200bpreventsdiabeticretinopathyassociatedchanges.CanadianJ. Diab.Care(34Suppl),4A,2010

3. FengB,ChenS,McArthurK,WuY,Chakrabarti S.P300regulatesmicroRNAmediatedmodulationofgenetranscriptionindiabetes.CanadianJ. Diab.Care(34Suppl),28A,2010

4. WangC,GeorgeB,ChenS,FengB,Chakrabarti S.OxidativestressinducedactivationofnovelDNArepairenzymes,ERCC1andERCC4,and increasedExtracellularmatrixproteinproductioninthekidneysindiabetes.Diabetes59(suppl1):A257,2010

5. McArthurK,FengB,WuY,ChenS, Chakrabarti S.microRNA-200bmediatesupregulationofVEGFindiabeticretinopathy.Diabetes59(suppl1): A64,2010.

6. FengB,ChenS,McArthurK,WuY,Chakrabarti S.miR146amediatedupregulationofextracellularmatrixproteinindiabeticretinopathy.Diabetes 59(suppl1):A63,2010.

7. McRaeS,HughesB,Chan N, McLachlin CM,ChanS,Weir MM.ComparisonofLHSCandBethesdathyroidFNABdiagnosticcategories CanadianAssociationofPathologists'AnnualMeeting.

8. NhanC, Driman DK,RabyM,SmithAJ,HunterA,SrigleyJ,McLeodRS.RectalcancerpathologyreportinginOntario:resultsofa2007auditof marginandlymphnodereporting.CanadianSurgeryForum,QuebecCity,September2010.

9. MessengerDE,Driman DK,McLeodS,RiddellRH,KirschR.Currentpracticepatternsamongpathologistsintheassessmentofvenousinvasion incolorectalcancerModPathol11;24:434A

10. PatrickL,Garcia B.CORM-2protectsagainstischemia-reperfusioninjuryinkidneytransplantationKidneyInternational

11. ZhengX,SuzukiM,ZhangX,IchimTE,ZhuF,LingH,ShunnarA,WangMH,Garcia B,InmanRD,MinWP.RNAi-mediatedCD40-CD154 interruptionpromotestoleranceinautoimmunearthritis.ArthritisResTher.2010;12(1):R13.

12. Gibson CJ,vonLubitzDKJE.CollaborativeLeadershipintheWorldofTechnology:BuildingTeamsofLeaders,itHealthcareCanadaConference, Toronto,ON,October4,2010.Alsogivenasaplatformpresentation.

13. Hammond R, Ang LC,SelcenD,GoobieS,CampbellC.Hypertonicmusculardystrophy:recentcasesandreviewCANP,Toronto,ON,October, 2010


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

14. VHayward,CTemple,M Joseph.Webcastsforclinicalclerks-Aninnovativewayforimprovingthefamilyphysician'sknowledgeandcompetence inmanagingskinlesionsPlatformpresentationbyVHaywardatthe16thCongressoftheInternationalConfederationforPlasticReconstructiveand AestheticSurgery,FairmountHotel,Vancouver,Canada,May22-27,2011. 15. AkilaSubasingheA,SamarabanduJ,Knoll J,KhanW,RoganP.AnaccurateimageprocessingalgorithmfordetectingFISHprobelocations relativetochromosomelandmarksonDAPIstainedmetaphasechromosomes.ComputerandRobotVision(CRV)2010Proceedings,Pages: 223-230.

16. AkilaSubasingheA,SamarabanduJ,Knoll JHM,KhanW,RoganPK.Animageprocessingalgorithmforaccurateextractionofthecenterlinefrom humanmetaphasechromosomes.ProceedingoftheInternationalConferenceonImageProcessing(IEEESignalProcessingSociety).Publishedin 2010.

17. Rizkalla K,HammC,AllevatoP.MantleCellLymphomain-situLW79TheXVthMeetingoftheEuropeanAssociationforHaematopathology, Uppsala,Sweden,Sept2010

18. FokTC,Daley TD,LapointeHJ,Tuck AB,ChambersAF,Jackson-BoetersL,DarlingMR.Osteopontin,HCAM/CD44andIntegrinαvβ3inSalivary GlandTumours.89thGeneralsessionandexhibitionoftheInternationalAssociationforDentalResearch.JournalofDentalResearch2011;90 (SpecialIssueA):2316.,SanDiego,California,UnitedStates,2011Mar19.

19. Mutrie,JC,Anborgh,PH,Tuck, AB,Chambers,AF.Osteopontinincreasesbreastcancercellsensitivitytospecificsignalingpathwayinhibitors. AACR-MRSJointConferenceonMetastasisandtheTumorMicroenvironment,Philadelphia,Pennsylvania,UnitedStates,2010Sep15.

20. SouterLH,PostenkaCO,AndrewsJD,RodenhiserDI,ChambersAF,Tuck AB.TheroleofS100A2inthetransitiontotheinvasivephenotypeas identifiedandcharacterizedbythehuman21Tseries3DmodelofbreastcancerprogressionAACR-MRSJointConferenceonMetastasisandthe TumorMicroenvironment,Abstract#A143,Philadephia,Pennsylvania,UnitedStates,2010Sep15.

Books & Book Chapters Published (July 1, 2010 to June 30, 2011)

1. WalpoleIslandFirstNationHeritageCentreTeam:JacobsD,WhiteD,WilliamsNC,WilliamsR,UWOEcosystemHealthResearchTeam: Bend J, CorbettB,DarnellR,HerbertCP,HillJ,KorenG,RiederM,SchoemanK,StephensC,TrickC,VanUumS.HealthRiskoftheWalpoleIsland FirstNationCommunityfromExposuretoEnvironmentalContaminants:aCommunity-BasedParticipatoryResearchPartnership.Chapter4, pp.49-55InAboriginalPolicyResearch:HealthandWell-Being,VolumeIX,EditedbyWhite,J.P.,Peters,J.,Dinsdale,P.andBeavon,D., ThompsonEducationalPublishing,Inc,Toronto,2011. 2. DanamRP,VergerP,KnaapA,Bend JR.GlycerolEsterofGumRosin(addendum)(Firstdraft).InWHOFOODADDITIVESSERIES:62: Safetyevaluationofcertainfoodadditives.InternationalProgrammeonChemicalSafety,WorldHealthOrganization,Geneva,2010pp119-132.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

3. DanamRP,VergerP,KnaapA,Bend JR.GlycerolEsterofTallOilRosin(addendum)(Firstdraft).InWHOFOODADDITIVESSERIES:62: Safetyevaluationofcertainfoodadditives.InternationalProgrammeonChemicalSafety,WorldHealthOrganization,Geneva,2010pp133-148.

4. Khan ZA, Chakrabarti S.Chronicdiabeticcomplications:endothelialcellsatthefrontlineIn:FrontiersinCardiovascularDrugDiscovery.Bentham SciencePublishersLtd,Chap9,pp121-137;2010.

5. Khan ZA, Chakrabarti S.Glucose-inducedcellularsignallingindiabeticretinopathyIn:VisualDysfunctioninDiabetes:TheScienceofPatient ImpairmentandHealthCare.HumanaPress.Ch.262010

6. ChambersA.F.,VandenbergT.A.,Tuck A.B.,AllanA.L.,RodenhiserD.I.Emergingsciencewithregardto‘cancerstemcells’-Lookingatdifferent molecularphenotypesinthatcategoryanddissectingouttriplenegatives.ASCO2011BreastCancerSymposiumEducationBook.

Case Reports Published (July 1, 2010 to June 30, 2011)

1. VilosAG,SmithsonDS,VilosG, Armstrong CE.UreterinHistopathologicSpecimen:AGynecologist'sNightmareFromtheDepartmentsof ObstetricsandGynecology(Drs.A.G.Vilos,Smithson,andG.A.Vilos),andPathology(Dr.Armstrong),St.Joseph’sHealthCareandLondonHealth SciencesCentre,TheUniversityofWesternOntario,London,Ontario,Canada.

2. FraserLA,KiaiiB,ShabanJ,IslamA,DiamantourosP,JonesPM,Tweedie E,VargheseR,VanUumS.Cardiacpheochromocytomapresenting duringpregnancy.BMJCaseReports2010;doi:10.1136/bcr.04.2010.2890


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

8.C – Invited Lectures - National

1. Chakrabarti S.“Pathogenesisofdiabeticretinopathy,endothelialcellsatthefrontline.”InvitedtalkattheFacultyofPharmaceuticalSciences. UniversityofBritishColumbia.Canada.2011/05.

2. WardAD,CrukleyC,McKenzieC,MontreuilJ,GibsonE,Gómez JA, Moussa M,BaumanG,FensterA.PodiumPresentation:“Registrationof invivoprostatemagneticresonanceimagestodigitalhistopathologyimages”.MedicalImageComputingandComputer-AssistedIntervention (MICCAI)ProstateImagingWorkshop.2010.

3. WardAD,CrukleyC,McKenzieC,MontreuilJ,Gómez JA, Moussa M,BaumanG,FensterA.“PodiumPresentation:“Registrationofinvivo medicalimagestodigitalhistopathologyimages”.AnnualMeetingofCanadianOrganizationofMedicalPhysicists.2010.

4. Gómez-Lemus JA.“ImagingApplicationsinProstateCancer.”CIHR.Canada.2010/11/19.

5. Hammond R.3DHistologyinCarotidAtheroma,CAIN2Symposium,Montreal,April29,2011

6. Hammond R.Graduateapplicants:CanadianMedicalSchoolsurveyandreporttoCCME,Toronto,May2011

7. John MA.“ESBL’sandMDRO’sImpactAcrosstheContinuumofCare.”CHICASWOntarioChapterEducationDay.Canada.2011/04/15.

8. John MA.“Multi-DrugResistantOrganisms:ProtectingOurselvesandourPatients.”PostAnaestheticCareConference.Canada.2011/04/16.

9. Khan ZA.“Stem/progenitorcellsindiabeticcomplications.”1stAnnualDiabetesResearchDay.Canada.2010/11.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

10. McRaeS,HughesB,Chan N, McLachlin CM,ChanS, Weir MM.“ComparisonofLHSCandBethesdathyroidFNABdiagnosticcategories.” CanadianAssociationofPathologists’AnnualMeeting.Canada.2010/07.

11. McLachlin CM.“Path2Quality-DevelopingBestPracticeGuidelinesinQualityAssuranceforOntario’sPathologists.”OntarioHospitalAssociation. Canada.2011/04/04.

12. McLachlin CM.“OverviewoftheCAPCancerChecklistforOvary.”WebEx/Teleconference.CancerCareOntario.Canada.2011/02/09.

13. McLachlin CM.“PoliticalandEconomicUpdate.”OntarioAssociationofPathologists,72ndAnnualGeneralMeeting.Canada.2010/10/01.

14. McLachlin CM.“GyneOncologySpecimens-StreamliningtheProcess.”CancerCareOntario,RegionalPathologyGyne-OncologyWorkshop. Canada.2010/10/28.

15. Parfitt J.“PathologyGastroenterologypresentedatCanadianAssociationofPathologistsAnnualResidentsReviewCourse.”CanadianAssociation ofPathologistsAnnualResidentsReviewCourse.Canada.2011.

16. Ramsay, D.“TheBrainTumourTissueBank:Past,PresentandFuture.”BrainTumourFoundationofCanada25thAnnualInformationDay. 2010/10. 17. Weir MM.“UseofImmunohistochemistryinGynecologicalTumours.”OntarioAssociationofPathology.Canada.2010/09.

18. Weir MM.“ThyroidFNATerminology:FromBethesdatoBeyond.”OntarioSocietyforMedicalLaboratorySciences.Canada.2010/10.

19. Weir MM.“ThyroidFNATerminology.”BramptonPeelMemorialHospital.Canada.2010/10.

20. Weir MM.“ThyroidFNABReporting:FromBethesdatoBeyond.”StratfordGeneralHospital,DepartmentofPathology.Canada.2011/02.

21. Weir MM.“GrossPathology.CanadianAssociationofPathologists,1stAnnualResidents’ReviewCourse.”Canada.2011/03.

22. Xu J.“GeneticTestingforDiagnosisandPrognosisofHumanDisease.”The4thMultidisciplinarySymposiumofOntarioChineseProfessors. Kellerman’sResort.Canada.2010/07/02.

23. Xu J.“FISHTestingforHER2inBreastCancer:BriefReviewsorGuidelines,ControversyandAdvancement.”GreatLakesChromosome Conference.Canada.2011/05/20.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

Invited Lectures - International

1. Chakrabarti S.“SlideSeminar.”DepartmentofPathology,BeijingSecondHospital,BeijingPRChina,2010/09.

2. Chakrabarti S,SenS,ChenS,FengB,LuiEMK.Panaxquinquefolius(Americanginseng)preventschroniccomplicationsintype1andtype2 diabetesthroughitsantioxidativeandantihyperglycemiceffects.The10thinternationalsymposiumonginseng.SeoulS.Korea,2010/10.

3. Chakrabarti S.“EpigeneticsandmiRNAinECMproteinproductionindiabeticretinopathy.”ARVOSpecialinterestgrouponExtracellularmatrixin oculardiseases.ARVOspecialinterestgroup.UnitedStates.2011/05.

4. WardAD,CrukleyC,McKenzieC,Montreuil J, Gómez JA, Moussa M,BaumanG,FensterA.“PodiumPresentation:“Registrationofinvivo medicalimagestodigitalhistopathologyimages”.AnnualMeetingofAmericanAssociationofPhysicistsinMedicine.2010.

5. Ramsay D.“Comentariossobreaspectosproblemáticosenelstudiodelostraumatismoscraneoencefálicos.”CursodeNeuropatologíaForense; PrimeroCongresodelaSociedadEspañoladePatologíaForense.Spain.2011/05.

6. Ramsay D.“Abordajeneuropatalógicoenloscasossospechososdemaltratoinfantil.”CursodePatologíaPediátraForense;PrimeroCongresode laSociedadEspañoladePatologíaForense.Spain.2011/05.

7. Ramsay D.“TraumatismosCraneo-encefálicos.”FinalYearMedicalStudents.UniversityofMálaga.Spain.2010/09.

8. Ramsay D.“TraumatismosCraneoencefálicos:Problemasfrecuentesparaelpatólogo.”CursodeFormaciónContinuadaenPatalogíaForense, AdministraciónPúblicadelaJuntadeAndaluciayInstitutoAndaluzdeAdministraciónPúblicaylaUniversidaddeMálaga(Departamentode MedicinaL.Spain.2010/09.

Abstracts Presented – National

1. AlturkustaniMA,Ang LC.“Rosette-formingglioneuronallesionof4thventricleinpatientwithNF1:hamartomavstumour?”CanadianAssociationof Neuropathologists50thAnnualMeeting.Canada.2010/10/14.

2. HamiltonB,SyJ,Ang LC,ChakrabartiS,MegyesiJ.“Molecularcytogeneticmarkersforrecurrentvsnon-recurrentmeningiomas.”.Canadian AssociationofNeuropathologists50thAnnualMeeting.Canada.2010/10/14.

3. AlSufianiF,Ang LC.“Giantcellchange/transformationinpituitaryadenoma.”CanadianAssociationofNeuropathologists50thAnnualMeeting. Canada.2010/10/14.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

4. FengB,ChenS,McArthurK,WuY,Chakrabarti S.IntravitrealdeliveryofmiR200bpreventsdiabeticretinopathyassociatedchanges.Canadian DiabetesAssociationAnnualmeeting,Canada2010/10.

5. FengB,ChenS,McArthurK,WuY,Chakrabarti S.P300regulatesmicroRNAmediatedmodulationofgenetranscriptionindiabetes.Canadian DiabetesAssociationAnnualmeeting,Canada2010/10

6. NhanC,Driman DK,RabyM,SmithAJ,HunterA,McLeodRS.“RectalcancerpathologyreportinginOntario:resultsofa2007auditofmarginand lymphnodereporting.”CanadianSurgeryForum.Canada.2010/09.

7. McIntoshK,ChandeN,Driman D,GregorJ,KhannaN.“Eosinophilicesophagitisandceliacdisease:Isthereanassociation.”CanadianDigestive DiseasesWeek.Canada.2011/03.

8. IrimiesA,Gabril M, Parfitt J, Joseph M.“Basalcellcarcinomawithpilomatricaldifferentiation:acasereportandreviewoftheliterature.”Canadian AssociationofPathololgists,AnnualMeeting2010.Canada.2010/07.

9. SiddiquiI,Driman DK, Gabril M.“AdenocarcinomaArisinginCysticRectalDuplication,PrecededbyRetrorectalDermoidCyst:ACaseReport.” CanadianAssociationofPathololgists,AnnualMeeting2010.Canada.2010/07.

10. Hammond R, Ang LC,SelcenD,GoobieS,CampbellC.Hypertonicmusculardystrophy:recentcasesandreview.CANP,Toronto,ON,October 2010

11. ChanS,GarciaF,Moussa M, Gabril M.“AninDepthStudyofExtraprostaticExtensionandMarginStatusinRadicalProstatectomies.”Canadian AssociationofPathololgists,AnnualMeeting2010.Canada.2010/07.

12. Gabril M,YoussefG.“AutomatedImageAnalysisOfMicrovascularDensityInClearCellRenalCellCarcinomaAndItsPrognosticUtility.”Canadian AssociationofPathololgists,AnnualMeeting2010.Canada.2010/07.

13. Gabril M,JacquesR, McLean C, Shkrum M.“TwoUnusualPresentationsofClostridiumSepticumAortitis.”CanadianAssociationofPathololgists, AnnualMeeting2010.Canada.2011/06.

14. LanZ,GeW,ArpJ,LiuW,BrandS,HealeyD,NicoletteC,Garcia B,WangH.“SuppressionofAntidonorAntibodyResponsebySolubleCD83 PreventsChronicRenalAllograftRejection.”Abstract#15B.CanadianSocietyofTransplantation2010AnnualScientificMeeting.Canada. 2010/08/12.

15. GeW,JiangJ,ArpJ,LiuW,JevnikarA,Garcia B,WangH.“RegulatoryT-CellGenerationandKidneyAllograftToleranceInducedbyMesenchymal StemCellsAssociatedwithIndoleamine2,3-DioxygenaseExpression.”Abstract#13B.CanadianSocietyofTransplantation2010AnnualScientific Meeting.Canada.2010/08/12.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

16. LanZ,GeW,ArpJ,JiangJ,LianD,LiuW,HealeyD,NicoletteC,JevnikarA,Garcia B,WangH.“InductionofKidneyAllograftToleranceby SolubleCD83AssociatedwithPrevalenceofTolerogenicDendriticCellsandExpressionofIndoleamine2,3-dioxygenase.”Abstract#16B. CanadianSocietyofTransplantation2010AnnualScientificMeeting.Canada.2010/08/12.

17. Gibson CJ,vonLubitzDKJE.CollaborativeLeadershipintheWorldofTechnology:BuildingTeamsofLeaders,itHealthcareCanadaConference, Toronto,ON,October4,2010.

18. GibsonE,CrukleyC,MontreuilJ,McKenzieC, Gómez J, Moussa M,RomagnoliC,ChinJL,BaumanG,FensterA,WardAD.“Registrationof prostateMRItodigitalhistopathology:Imageguidedslicingandretrospectivefiducial-basedvirtualtissuereassmbly.ImagingNetworkOntario Symposium.Toronto,Canada.January2011.”Canada.2011/01/31.

19. AkilaSubasingheA,SamarabanduJ,Knoll J,WahabK,RoganP.AnaccurateimageprocessingalgorithmfordetectingFISHprobelocations relativetochromosomelandmarksonDAPIstainedmetaphasechromosomes.CanadianConferenceonComputerandRobotVision(CRV).2010.

20. AkilaSubasingheA,SamarabanduJ,RoganP,Knoll J.Developmentofanimageprocessingalgorithmforaccurateextractionofthecenterline fromhumanmetaphasechromosomes.InternationalConferenceonImageProcessing(ICIP)sponsoredbyIEEESignalProcessingSociety,2010.

21. CarageaM,SyJ,Parfitt JR, Driman DK.“TumourbuddinginstageIIAcolorectalcarcinoma:anewseni-quantitativemethodofassessment.” DepartmentofPathology,UniversityofWesternOntario,London,Canada;DepartmentofAnatomicalPathology,ConcordHospital,Sydney, Australia.CanadianAssociationofPathologists.Canada.2011.

22. CarageaM,SmithPM,Howlett C, Parfitt JR, Chakrabarti S.“Progressingmulitcysticmesotheliomaoftheliver.”DepartmentofPathology, UniversityHospital,UniversityofWesternOntario,London,Ontario;DepartmentofPathology,WindsorRegionalHospital,Windsor,Ontario. CanadianAssociationofPathologists.Canada.2011.

23. MosliM,Parfitt JR,GregorJC.“Riskfactorsandsequellaeofischemiccolitis(IC).”DivisionofGastroenterology,DepartmentofMedicine, UniversityofWesternOntario,London,Ontario.CanadianAssociationofGastroenterology(CanadianDigestiveDiseasesWeek).Canada.2010.

24. AnborghPH,MutrieJC,Tuck AB,ChambersAF.“Pre-andpost-translationalregulationofosteopontinincancer.”LondonRegionalCancer Program.Canada.2011/06.

25. SiuVM,Xu, J.“Array-BasedCGHFindingsinTwoChildrenwtihTARSyndrome,onewithandonewithoutthecommon1q21.1deletion..”Abstract No.283.ACMGAnnualClincalGeneticsMeeting.Canada.2011/03/16.

26. Xu J.“FISHTestingforHER2inBreastCancer:BriefReviewsofGuidelines,ControversyandAdvancement.”The49thAnnualGreatLakes Conference.Canada.2011/05/19.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

Abstracts Presented – International

1. MegyesiJF,HajiF,PatelY,Ang LC.“SpinalEpiduralAngiolipoma-ALiteratureReview.”Neuro-oncology,12:29-29Suppl.4NOV2010.Advances inInflammatoryBowelDiseasesCrohns&ColitisFoundationNationalClinical&ResearchConference.UnitedStates.2010/12/09.

2. AlturkustaniM,Ang LC.“Glioneuronaltumourofthe4thventricleassociatedwithneurofibromatosistype1.”BrainPathology,20:56-56Suppl.1 SEP2010.17thInternationalCongressofNeuropathology(ICN2010).Austria.2010/09/11. 3. Darling MR,McCordC,Jackson-BoetersL,DaleyTD.MarkersofpotentialmalignancyinChronicHyperplasticCandidiasis.88thGeneralsession andexhibitionoftheInternationalAssociationforDentalResearch.Barcelona,Spain.July14-17,2010

4. FokTC, Daley TD,LapointeHJ,TuckAB,ChambersAF,Jackson-BoetersL,DarlingMR.Osteopontin,HCAM/CD44andIntegrinαvβ3inSalivary GlandTumours.89thGeneralsessionandexhibitionoftheInternationalAssociationforDentalResearch.SanDiego,California,USA.Mar16-19, 2011.

5. MessengerDE,Driman DK,McLeodS,RiddellRH,KirschR.“Currentpracticepatternsamongpathologistsintheassessmentofvenousinvasion incolorectalcancer.”USandCanadianAcademyofPathologyMeeting.USandCanadianAcademyofPathology.UnitedStates.2011/03.

6. Gabril M,YoussefG.“AutomatedImageAnalysisOfMicrovascularDensityInClearCellRenalCellCarcinomaAndItsPrognosticUtility.”USCAP meeting2010.UnitedStates.2010/07.

7. ChanS,GarciaF,ChinJ,Moussa M, Gabril M.“DoBenignGlandsattheResectionMarginIncreasetheRiskofBiochemicalFailurePostRadical Prostatectomy?.”USCAPmeeting2011.UnitedStates.2011/03.

8. Gabril M,YousefG.“AutomatedImageAnalysisofEndoglinandmicrovasculardensityImmunoreactivityinClearCellRenalCellCarcinomaand StudyTheirPrognosticSignificance.”USCAPmeeting2011.UnitedStates.2011/03.

9. Gabril M,MetiasS,MoussaB,Moussa M,YousefG,“RiskofProstaticcarcinomafollowingadiagnosisofAtypicalSmallAcinarProliferation:a multicenterretro-respectivestudy.”USCAPmeeting2011.UnitedStates.2011/03.

10. GardonRoseJ,Gibson C,KushionML,vonLubitzDKJE.BuildingtheTogetherWeCanHealthImprovementCampaigninCentralMichigan, CentralMichiganUniversity–UniversitiesAlliedforEssentialMedicines(CMU-UAEM)GlobalandLocalHealthDisparitiesConference,Mount Pleasant,MI,April2-3,2011.(Platformpresentation)

11. GoubranM,KhanAR,CrukleyC,BuchananS,CantorD,SantyrB,deRibaupierreS,MirsattariS,Hammond R,ParrentA,PetersTM.Robust registrationofsparselysectionedhistologytoex-vivoMRIoftemporalloberesections.SPIE,Feb2011


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

12. ValiyevaF,JiangF,ElmaadawiA,YeeSP, Moussa M,RaptisL,IzawaJ,YangB,GreenbergNM,WangF,XuanJW.“Proto-oncogenicactivityofa novelTRIM59gene,characterizedinmousecancermodels.”5thGarvanSignallingSymposium(ASBMB).Australia.2010/10/18.

13. GibsonE,CrukleyC,Gomez JA, Moussa M,BaumanG,FensterA,WardAD.“TissueBlockMRIForSliceOrientation-IndependantRegistration ofDigitalHistologyImagestoExVivoMRIoftheProstate.”UnitedStates.2011/03/30.

14. GibsonE,CrukleyC,McKenzieC,Gomez JA, Moussa M,BaumanG,FensterA,WardAD.“Image-guidedprostatesectioningsupporting registrationofgradedcancerousfocifromdigitalhistopathologyimagestoinvivoMRI:aninteractive3Dvisualizationtool.SPIEmedicalimaging. Orlando,USA.February2011.”UnitedStates.2011/02/28.

15. KhatamianfarV,ValiyevaF,IzawaJ,GleaveM,RennieP,Moussa M,XuanJW.“TRIM59,anovelproto-oncogene,asabiomarkerformultiple humancancersdetectingearlytumorigenesis5thGarvanSignallingSymposium.”Australia.2010/10/18.

16. PatelV,ChandeN,Driman DK,GregorJC,Parfitt JR,PonichT,SchwarzUI,DresserGK,KimRB.“Theexpressionofdrugeffluxtransportersin celiacdisease.”AmericanAssociationofGastroenterology(DigestiveDiseaseWeek).UnitedStates.2010.

17. SyK,Al-HaddadS,Parfitt JR,StreutkerCJ.“Inflammatorypseudotumouroftheesophagus:areportof5cases.”UnitedStatesandCanadian AssociationofPathologists.UnitedStates.2010.

18. Xu J,HammC,AllevatoP.“ARareCasehavingt(8;22)andt(14;18)DoubleHitwithupto3Copiesoft(8;22)andMorphologicand ImmunophenotypicFeaturesofLargeBCellLymphomaofPossibleFollicularOrigin..”AbstractNo.435.TheAmericanSocietyofHumanGenetics 60thAnnualMeeting.UnitedStates.2010/11/02.

19. ZhangL,ChenD,RiederMJ,Bend JR.“AttenuationofoxidativeandnitrosativestressbypureconstituentsofTraditionalChineseremedies.”9th MeetingofConsortiumforGlobalizationofChineseMedicine(CGCM),HongKong.2010/08/23.

20. SiuVM,Xu J.“ADeNovo1.3MbDeletionin17p21.31AssociatedwithPartialAgenesisofCorpusCallosumandPervasiveDevelopmentDisorder.” AbstractNo.19.FirstAnnualISCAConsortiumConference.UnitedStates.2011/01/31.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

8.D – Research Funding

External Funding

1. RichmondC,Bend JR(Co-applicant).CIHRcommunitybasedgrant.“FirstNationsPerceptionsoftheHealthImpactofLivingNearaSolidWaste Facility.TotalFunding$25,000.From2011/06to2012/05.

2. FergusonS,Bend JR(Co-applicant).OntarioMinistryofResearch&Innovationresearchresourcegrant.“LondonRegionalCellandinVitro ImagingFacility.”TotalFunding$469,400.From2007/04to2012/03.

3. TrickC,Bend JR(Co-applicant).InternationalDevelopmentResearchCentre–Environment&NaturalResourcesManagement.“PendingCrisisat LakeNaivasha,Kenya:diagnosisandtreatmentofthreatstoecosystemhealthduringclimatechange.TotalFunding:$600,000.2008/05to 2012/04. 4. Bend JR (PI).CIHROperatingGrant.“ModulationofGeneExpressionandProteinStructure/ActivitybyBilirubin.”TotalFunding$685,185.2003/10 to2011/03.

5. RiederMJ(PI),Bend JR (PI).OntarioMinistryofResearchandInnovation:InternationalStrategicOpportunitiesProgram(ISOP).“ImprovingDrug SafetybyComplementaryUseofTraditionalChineseMedicine.”TotalFunding:$150,000.2008/03to2011/04 6. Chakrabarti S(Canada);LiX(China).CIHRChina-CanadaJointHealthResearchInitiative.“PreventativeEffectsandtheMechanismofactionofa NovelMutantofFibroblastGrowthFactoronDiabeticCardiomyopathy.”TotalFunding:$146,100.2011/01to2013/12


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

7. Chakrabarti S (PI).CanadianDiabetesAssociation.“Pathogenesisofdiabeticretinopathy”.TotalFunding:$275,000.2010/07to2013/06

8. Chakrabarti S (PI).OICR.TotalFunding:$250,000.2010/07to2011/07

9. Chakrabarti S (PI).ActelionPharmaceuticalsInc.“EffectofMacitentantreatmentondiabeticnepropathy”.TotalFunding:$30,000.2010to2012 10. Chakrabarti S (PI).FTAOntarioResearchFund.“PreventativeEffectsofGinseng”.TotalFunding:$196,000.2008/08to2013/03

11. Chakrabarti S (PI).HeartandStrokeFoundationofOntario.TotalFunding:$151,100.2008/07to2011/06

12. Chakrabarti S (PI).CIHR.“Oncofetalfibronectinindiabeticheartdisease”.TotalFunding:$559,855.2006/07to2011/06

13. Gabril MY(SiteInvestigator).CanadianInstitutesofHealthResearch(CIHR).“Investigatingthefactorsaffectingthemetastaticpotentialofthe renaltumors.”TotalFunding$321,000.2009/08to2010/08

14. BaumannG(PI),Gómez JA (Co-I), Moussa M (Co-I).CIHRTeaminImageGuidedProstateCancerManagement.“HistopathologicValidationof Pre-operativeProstateCancerImaging”.TotalFunding:$4,642,805.2008/04to2013/03

15. Hammond RR,SpenceD(PI).CanadianAtherosclerosisImagingNetwork(CAIN),fundedbyCIHRandtheHeart&StrokeFoundationofCanada. PathologyImageAnalysisCore.TotalFunding:$25,000.2010to2012.

16. John MA,(Siteinvestigator)LoebM(PI).OntarioMinistryofHealth&LongTermCare.“ArandomizedcontroltrialofsurgicalmasksvsN95 respiratorstopreventinfluenzainhealthcareworkers.”TotalFunding:$250,000.2009topresent

17. John MA.OntarioMinistryofHealth&LongTermCare.“EvaluationofaPilotTestoftheProvincialHandHygieneProgramforHospitals.”Total Funding:$100,000.2009to2010

18. John MA.“CanadianNosocomialInfectionSurveillanceProgram(CNISP)”.TotalFunding:$7,000peryeartoprovidehospitalprofiles/quarterly reports.

19. John MA.“ASurveyofHealthCareProfessionalsontheuseofPersonalProtectiveEquipmentduringthePandemicH1N1Influenzawavefrom SeptembertoDecember2009.”TotalFunding:$7,800.2010

20. John MA(SiteInvestigator).“DevelopmentofaNationalSurveillanceSystemforCentralVenousCatheterBloodstreamInfections(CNISP).”Total Funding:$3,000peryear2007topresent


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

21. John MA(SiteInvestigator).“NationalSurveillanceofMethicillinResistantStaphylococcusaureusinCandianAcuteCareHospitals(CNISP)”.Total Funding:$7,500peryear2000topresent

22. John MA(SiteInvestigator).“NationalSurveillanceofVancomycinResistantEnterococcusfaecalisandfaeciuminCandianAcuteCareHospitals (CNISP).”Totalfunding:$2,500peryear.2000topresent

23. John MA(SiteInvestigator).“SurveillanceforClostridiumdifficileassociateddiarrhea(CDAD)withinacutecareinstitutions(CNISP).”TotalFunding: $3,000/year2008topresent

24. Khan ZA.CanadianInstitutesofHealthResearch.“CellularandMolecularBasisofInfantileHemangiomaPathogenesis”.TotalFunding:$219,813. 2009/10to2012/09

25. Khan ZA.CanadianDiabetesAssociation.“VascularStemCellsinDiabeticComplications”.TotalFunding:$189,000.2009/07to2012/06 26. Khan ZA.Heart&StrokeFoundationofCanada,NewInvestigatorAward.TotalFunding:$300,000.2010/07to2015/06.

27. Lannigan R,McBeanG,SnidvongsA.InternationalDevelopmentResearchCentre(IDRC),CanadianInstitutesofHealthResearch,theNatural SciencesandEngineeringResearchCouncil,andtheSocialSciencesandHumanitiesResearchCouncil.“InternationalResearchInitiativeon AdaptationtoClimateChange(IRIACC)CoastalCitiesatRisk(CCaR):BuildingAdaptiveCapacityforManagingClimateChangeinCoastal Megacities.”TotalFunding:$1,250,000.2011/03to2016/06

28. BauchC(PI),McLachlin CM (Co-I).CanadianInstitutesofHealthResearch(CIHR),Infection&Immunity.“CervicalCancerScreeningintheEraof HPVVaccination:usingmathematicalandeconomicmodelstoguidescreeningpolicy.”TotalFunding:$228,000.2008/07to2011/12.

29. Moussa M (Collaborator),WardAD(Co-PI).Thisprojectwas(partially)fundedthroughtheCancerImagingNetworkofOntario(CINO)supported byCancerCareOntariowithfundsfromtheMinistryofHealthandLong-TermCare”..““Evaluationof18F-cholinePET/CTimagingforprostate biopsyguidanceusingdigitalpathology-based3Dprostatecancermapsand3DTRUS-guidedtargetedbiopsy”.TotalFunding:$70,000.2011/05 to2013/05

30. Xuan J (PI), Moussa M (Co-I).OntarioInstituteforCancerResearch.“MoleculardiagnosisandtherapyofprostatecancerbyUTMD(ultrasound targetedmicrobubblesdestruction)technologyingeneticallyengineeredmousemodels.”TotalFunding:$542,449.2008/07to2011/06.

31. Shkrum MJ (PI).TransportCanada.“MOVES:MotorVehicleCollisionandMotorVehicleandVehicleEquipmentDefectInvestigations.”Total Funding:$778,750.2010/10to2013/03.

32. Tuck AB.CanadianBreastCancerResearchAlliance.“Modelingofcriticalstepsinmammarytumorprogressionin3Dcultureandinvivo.”Total Funding:$432,252.2005/01to2010/12


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

33. Tuck AB,ChambersA(PI).CanadianInstitutesofHealthResearch.“Stepsinmetastasis:Identifyingtherapeutictargets.”.TotalFunding:$134,825. 2005/01to2010/12

34. RakovitchE,Tuck ABetall(co-applicants).CandianBreastCancerResearchAlliance.“LobularCarcinomaInSitu:APopulation-basedAnalysis”. TotalFunding:$585,545.2006to2010 35. RakovitchE,Tuck AB(Co-I).CanadianBreastCancerResearchAlliance.“Ductalcarcinomainsitu:Apopulation-basedanalysis.”TotalFunding: $254,875.2007/01to2012/12

36. Koropatnickand10others,Tuck AB(Collaborator).CanadianInstituesofHealthResearch.“Londonstrategictraininginitiativeincancerresearch andtechnologytransfer”.TotalFunding:$325,000.2009to2015

37. TurleyE, Tuck ABetal(co-applicants).CanadianBreastCancerFoundation-OntarioRegion.“TheroleofRHAMM/HMMRinbreastcancer susceptibilityandprogression”.TotalFunding:$144,646.2011to2014

38. ChambersAF, Tuck ABetal.BreastCancerSocietyofCanada.“StudiesofOsteopontinasaBiomarkerinBreastCancerClinicalTrials”.Total Funding:$52,500.2010to2011

39. WinquistE,Tuck AB.OntarioInstituteforCancerResearch.“OICRTranslationalResearchTeamAward”.TotalFunding:$337,862.2010to2013

40. Xu, J.CanadaFoundationforInnovation–InfrastructureOperaringFund.TotalFunding:$16,395.2010.

Internal Grant Funding

1. Ang LC.PathologyInternalFundsforAcademicDevelopment.“CytogenicStudyforAggressiveandRecurrentMeningiomas,usingFISHprobes for1pand14q”.TotalFunding:$5,000.2009/01to2010/12

2. Ang LC.PathologyInternalFunds.“NeuropathologyResidencyProgram-teachingandresearchdevelopment”.TotalFunding:$3,000.2010/07to 2011/06.

3. Chakrabarti S (PI).PathologyInternalFundsforAcademicDevelopment.“MicroRNAalterationinthesquamouscellcarcinomaofpharynx.” TotalFunding:$5,000.2009/03to2011/01

4. Driman DK.PathologyInternalFundsforAcademicDevelopment.“LHSCExperiencewithHepaticResectionforMetastaticCancer(Chemotherapy EffectinHepaticResectionsforMetastaticColorectalAdenocarcinoma)”.TotalFunding:$3,041.2011topresent.


SEC

TIO

N 8

– G

RA

DU

ATE

PRO

GR

AM

S

5. Driman DK.PathologyInternalFundsforAcademicDevelopment.“Tumorbuddingandperineuralinvasionareindependentandreproducible prognosticfactorsincolorectalcarcinoma.”TotalFunding:$5,000.2010/01to2011/12

6. Driman DK.PathologyInternalFundsforAcademicDevelopment.“EffectofGEWFsolutiononsurvivalincoloncancer”.TotalFunding:$5,000. 2010to2012.

7. Driman, DK,CarageaM,SyJ,ParfittJ.PathologyInternalFundsforAcademicDevelopment“TumourbuddinginstageIIAcolorectalcarcinoma:a newsemi-quantitativemethodofassessment”.TotalFunding:$5,000.2010to2012.

8. Driman DK.PathologyInternalFundsforAcademicDevelopment.“Useofanelasticconnectivetissuestain(Movatpentachrome)tohighlight venousinvasioninesophagealandgastroesophagealjunctionadenocarcinomas.”TotalFunding:$5,000.2009/03to2011/02

9. Garcia B.LHSCMultipleOrganTransplantProgram.TotalFunding:$70,000.2010/08to2011/09

10. Hammond RR.PathologyInternalFundsforAcademicDevelopment.“HighfieldMRI/Neuropathologycorrelativestudies”.TotalFunding:5000. 2009/03to2011/07

11. Howlett C (PI).PathologyInternalFundsforAcademicDevelopment.“Evaluationofthevalueofanelastictissuestaininidentificationoflarge vesselinvasioninlungcarcinoma”.TotalFunding:$2,000.2010/04to2012/03

12. Howlett C (PI).PathologyInternalFundsforAcademicDevelopment.“Investigationofplasmacellproliferationsinassociationwithmetastatic carcinomatothebonemarrow.”TotalFunding$3,000.2010/12to2012/11.

13. Hussain Z,McGavinM(PI).WesternAcademicDevelopmentFund.“PopulationdynamicsofStaphylococcusaureuscarriageinhemodialysis patientsandassociationwithadverseinfectionsrates.”TotalFunding$20,000.2010to2012. 14. Khan ZA.LawsonHealthResearchFund,IRF-005-09.“MechanismsofHemangiomaStemCellPlasticity:StudentfundingforA.Kleinman”.Total Funding:$9,000.2009/07to2011/06

15. Moussa, M.DepartmentofPathologyInternalFundsforAcademicDevelopment.““LocalizationofPLA2Rantibodyinmembranousnepropathyand clinicalcorrelation”.TotalFunding:$5,000.2010/07to2012/06

16. Ramsay DA (PI),MegyesiJ(Co-Director).LondonBrainTumourResearchFundFoundation.““CanadianBrainTumourTissueBank”,Ongoing AnnualMaintenanceGrant1998-present($80,000perannum)”.TotalFunding:$960,000.1998to2011

17. Rizkalla K.SchulichSchoolofMedicine&Dentistry.UndergraduateMedicalEducationSummerStudentProject.TotalFunding:$4,251.Spring 2011.


SECTIO

N 8 – G

RA

DU

ATE PRO

GR

AM

S

18. Rizkalla K.PathologyInternalFundsforAcademicDevelopment.“Learningmoduleforblood:ahemotopathology/haemtologyresource.”Total Funding:$3,000.2010/01to2011/12

19. ChambersA,Tuck AB.LondonRegionalCancerProgramSmallGrantsforCancerResearchandTraining.“Supplementtoa5-yearCIHRaward (MOP42511).”TotalFunding:$50,000.2009/01to2010/12

20. Tuck AB.LondonRegionalCancerProgramSmallGrantsforCancerResearchandTraining.“Pre-signalingtargetstoblockmalignancy-promoting effectsofosteopontinonbreastcancer.”TotalFunding:$49,884.2009/01to2010/12

21. Wehrli BW, Weir MM.PathologyInternalFundsforAcademicDevelopment.“ImmunomarkerValidationStudyforCytology,TheUniversityof WesternOntario”.TotalFunding:$5,000.2010/01to2012/01


SEC

TIO

N 9

– A

WA

RD

S &

HO

NO

UR

S

SECTION 9: Awards, Honours & Distinctions

2010-11

FellowoftheCanadianAcademyofHealthSciences,Dr.JackBend

Member,CouncilofCanadianAcademiesExpertPanelontheIntegratedTestingofPesticides,Dr.JackBend.

MarionSpencerFayAwardNominee,DrexelUniversityCollegeofMedicine,Dr.BerthaGarcia

Dean’sAwardofExcellenceforStaff–LindaJackson-Boeter,DepartmentofPathologyTechinician

BestSkinWeekProfessorAward,SchulichSchoolofMedicine&Dentistry,Dr.MariammaJoseph

Heart&StrokeFoundationofCanada,NewInvestigatorAward,Dr.ZiaKhan

ProstateNationalCancerPathology&StagingMultidisciplinaryExpertPanelMember,Dr.MadeleineMoussa

WesternHumanitarianAward(Team),Drs.CharlesTrick,JackBend,IrenaCreedandRegnaDarnell.

FellowoftheRoyalSocietyofMedicine,Dr.DavidWhite


SECTIO

N 9 – AW

AR

DS &

HO

NO

UR

S

2009-10

2010CanadianLiverFoundation/CanadianAssociationfortheStudyoftheLiverGoldMedal-Dr.PaulAdams(Dept.ofMedicinecrossappointee)

CIHRNewInvestigatorAward-Dr.TianqingPeng(Dept.ofMedicinecrossappointee)

Dean’sAwardofExcellenceforStaff-TraceyKoning,GraduateProgramAssistant

TheUSCTeachingHonourRollAwardofExcellence–Dr.RobHammond

TheUSCTeachingHonourRollAwardofExcellence–Dr.KamiliaRizkalla

TheUSCTeachingHonourRollAwardofExcellence–Dr.MathieuCastonguay

2008-09

TheUniversityofWesternOntarioDistinguishedUniversityProfessorship-Dr.JackBend,Pathology,andDr.MichaelStrong,ClinicalNeurologicalSciences

StillerCenterPrizeandOntarioGenomicsPrecommercializationInvestmentforsinglecopyprobetechnologydevelopment-Drs.JoanKnollandPeter

Rogan.ThiswasawardedattheCanadianMedicalHallofFame,April,2009

TheUSCTeachingHonourRollAwardofExcellence–Dr.AaronHaig

TheUSCTeachingHonourRollAwardofExcellence–Dr.DavidDriman

TheUSCTeachingHonourRollAwardofExcellence–Dr.CandaceGibson

TheUSCTeachingHonourRollAwardofExcellence–Dr.MadeleineMoussa

TheUSCTeachingHonourRollAwardofExcellence–Dr.KamilliaRizkalla

2007-08

SchulichEducatorAward–Dr.MariammaJoseph

Dean’sAwardofExcellence(Team)–Dr.WeipingMin,MultiOrganTransplantProgram(LHSC)

TheUniversityofWesternOntarioFacultyScholar–Dr.SubrataChakrabarti

TheUSCTeachingHonourRollAwardofExcellence–Dr.TomDaleyforexcellenceinteachinginDentistry

TheUSCTeachingHonourRollAwardofExcellence–Dr.BerthaGarciaforexcellenceinteachinginMedicine

TheUSCTeachingHonourRollAwardofExcellence–Dr.MadeleineMoussaforexcellenceinteachinginMedicine

2006-07

SchulichEducatorAward–Dr.RobHammond

Dean’sAwardofExcellenceforStaff–CherylCampbell


SEC

TIO

N 9

– A

WA

RD

S &

HO

NO

UR

S

Department of Pathology Awards

Faculty Awards

Dr.M.E.KirkAwardforExcellenceinResidentEducation

•2010JoseGomez

•2009MicheleWeir

•2008DavidDriman

•2007BretWehrli

•2006MariammaJoseph

Annual Pathology Research Day Awards

Chair’sAwardforBestPresentationbyaResident

•2011HectorLi

•2010SusanneChan

•2009MathieuCastonguay

•2008ChadLuetke

•2007ChristopherHowlett

SecondPlaceAwardforBestPresentationbyaResident

•2011MaraCaragea

•2010HectorLi

•2009HectorLi

•2008BassemMoussa

•2007BassemMoussa

Dr.M.DariaHaustAwardforBestPresentationbyaGraduateStudent

•2011AndrewPepper(supervisorDavidWhite)



•2008KatieMoisse(supervisorMichaelStrong)

•2007KatieMoisse(supervisorMichaelStrong)

SecondPlaceAwardforGraduateStudents

•2011JamieBelo(supervisorRennianWang)

•2010XushengZhang(supervisorWeipingMin)

•2009YuofengZuo(supervisorChandanChakraborty)

•2008YuofengZuo(supervisorChandanChakraborty)

•2007HaoWang(supervisorBerthaGarcia)

BestPosterPresentationbyaGraduateStudent

•2011JessicaDubrick(supervisorRennianWang)

•2010ManpreetSingh(supervisorTianqingPeng)

•2009ArthurLau(supervisorZhuxuZhang)

•2008XushengZhang(supervisorWeipingMin)

•2007LesleySouter(supervisorsAnnChambers&AlanTuck)

Pathology Resident Awards

Dr.MarvinS.SmoutResidentTravelAward

•2005JeremyParfitt

•2004RosammaGeorge

•2001OmarHakim


SECTIO

N 9 – AW

AR

DS &

HO

NO

UR

S

Pathology Graduate Awards

DutkevitchMemorialFoundationGraduateStudentTravelAward

inPathology

•2011EmilyKeats(PhD),RokhsanaMortuza(PhD),

WahabKhan(PhD)

•2010MatthewRiopel(MSc),andKaraMcArthur(MSc)

•2009KaraMcArthur(MSc)

•2008MansaKrishnamurthy(MSc)

•2007NellyHashem(MSc)andAbudiAwaysheh(MSc)

Dr.CameronWallaceGraduateStudentAwardinPathology

•2011YuexiuWu(PhD)

•2010AndrewPepper(PhD)

•2009XushengZhang(MSc)

•2008MansaKrishnamurthy(MSc)

•2007KatieMoisse(PhD)andYufengZuo(PhD)

Undergraduate Awards

FredLewisAward(forthestudentwiththehighestmarkinthecourse,

Pathology3240a)

•2011DeelanPatel

•2010PeterLynch

•2009BrandonBrillon

•2008Kun(Eric)Huh

•2007MichelleHannaandElizabethRoach

GoldMedalAward(fortheBMSc.Pathology/Toxicologystudentwiththe

highestgrade)

•2011LauraBowie

•2010KunHuh(Eric)

•2009JulieKoppes

•2008AmandaVieira

•2007HeidiDeBoer

PCShahScholarshipAward

•2011RinuPazhekattu

•2010EricBol

•2009ElizabethRoach

•2008NickSutherland

ColinAndersonAward(forthestudentwiththehighestmarkinthecourse,

Pathology3240b)

•2011DeelanPatel

•2010JamesClem

Acknowledgements


SEC

TIO

N 9

– A

WA

RD

S &

HO

NO

UR

S

The Department of Pathology Annual Report is produced by Kathilyn Onn,

Media Specialist and Mair Hughes, Administrative Officer. With special

thanks to our clinical and academic leaders for their contributions and to

Drs. David Driman and Jack Bend for hours of proof-reading.

Documents

Department of Pathology ANNUAL REPORT - University of Western