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David R. McWilliams, Ph.D. Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics • Bioinformatician IV • Bacterial Proteomics • Carbohydrate and Lipid Chemistry

David R. McWilliams, Ph.D. Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics Bioinformatician IV

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Page 1: David R. McWilliams, Ph.D. Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics Bioinformatician IV

David R. McWilliams, Ph.D.Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics

• Bioinformatician IV• Bacterial Proteomics• Carbohydrate and Lipid Chemistry

Page 2: David R. McWilliams, Ph.D. Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics Bioinformatician IV

Bioinformatic Infrastructure Development

• Familiarity with both Wake Forest computational clusters

• Evaluation, comparison, installation and maintenance of open-source software tools

• Computational ‘pipeline development’– Automated processing, summary and analysis of

thousands of files. Documentation of process.• NGS Pipeline– ‘One button’ NGS data analysis from mapped reads to

the variant file.

Page 3: David R. McWilliams, Ph.D. Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics Bioinformatician IV

Clinical Sequencing Support

• Participation in training for Life Technologies’ Ion Torrent bioinformatics pipeline

• Statistical analysis of Ion Torrent variant calls

Page 4: David R. McWilliams, Ph.D. Section of Statistical Genetics, Department of Biostatistical Sciences, Center for Public Health Genomics Bioinformatician IV

Group Assets

• Extensive experience with genetic data QC issues and procedures

• Novel analysis algorithm development• Automated annotation software development• Machine learning experience• SAS, R, Perl, Java, Fortran, C, shell, SQL