DAPT Duration in PCI: The Art of Medicine When the

Science Might Not Exist

European and US Guidelines

European and US Guidelines

“Optimal” DAPT Duration and DES RevascularizationA Less than “Optimal” Evidence Basis

Long-Term DAPT: Bleeding Risk

PRODIGY: 2-Year Death/MI/Stroke

PRODIGY: 2-Year BARC 2, 3, or 5 Bleeding

PRODIGY: Outcomes Relative to Stent Type and DAPT Duration

PRODIGY: Outcomes Relative to Stent Type and DAPT Duration

PRODIGY: Outcomes Relative to Stent Type and DAPT Duration

REAL-LATE/ZEST-LATE: 2-Year End Points

RCT Sample Size Calculations (6 mo vs 12 mo)Delta, Event-free Duration, Time to End Point Influence

(N)

DAPT Trial: Total Enrollment

Pooled Xience EES AnalysisTiming of First DAPT Interruption and ST Through 1 Year

RESOLUTE Pooled DAPT Interruption AnalysisTiming of First DAPT Interruption and ST Through 1 Year

RESOLUTE Pooled DAPT Interruption AnalysisTiming of First DAPT Interruption and ST Through 1 Year

Global Leaders

WOEST1-Year Outcomes: ASA/Clopidogrel/Warfarin vs

Clopidogrel/Warfarin

DAPT Trial Randomization Rates

Conclusions

Conclusions (cont)

Conclusions (cont)

Conclusions (cont)

双重抗血小板治疗的合适使用时间及如何合理应用

展望

Spanish Perspective

Recommendation for 12 Months of DAPT After DES Implantation

Recommended Duration of DAPT After PCI

Discontinuation of Antiplatelet Therapy as Predictor of Stent

Thrombosis

Pipeline: RCT on DAPT After Stenting

EES vs PES: 1-Year Meta-Analysis (n = 6683)

References

References (cont)

References (cont)

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

Abbreviations (cont)

Abbreviations (cont)