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CV of Yoichi Kosodo, Ph.D. Personal data Name KOSODO, Yoichi Nationality Japanese Current position Principal Investigator, Mechanoneuroscience Lab,

Korea Brain Research Institute (KBRI) Mailing address 61 Cheomdan-ro, Dong-gu, Daegu, 701-300, South Korea

phone +82-53-980-8440; +82-10-7440-3840 (mobile) e-mail: kosodo@kbri.re.kr

Professional career 04/2015 – Principal Investigator, Korea Brain Research Institute, Daegu, South Korea 09/2010 – 03/2015 Associate Professor, Department of Anatomy, Kawasaki Medical School,

Kurashiki, Japan 09/2005 – 08/2010 Research Scientist, Laboratory for Cell Asymmetry, RIKEN Center for

Developmental Biology, Kobe, Japan 07/2001 – 08/2005 Postdoctoral Fellow, Laboratory of Wieland B. Huttner, Max-Planck-Institute

of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany Education 04/1998 – 03/2001 Ph.D. in Life Sciences, Laboratory of Koji Yoda, Dept. of Biotechnology,

University of Tokyo 04/1996 – 03/1998 M.Sc. in Life Sciences, Dept. of Biotechnology, University of Tokyo 04/1991 – 03/1996 B.Sc. in Engineering, Dept. of Chemistry and Biotechnology, University of

Tokyo Honors/Fellowships 2000 – 2002 Research Fellowship of the JSPS for PhD student 1998 – 1999 Junior Research Associate at the RIKEN Institute Invited lectures and seminars (2008-date) 2016 Lecture in King’s College London, London, UK

Presentation in the Royal Society Scientific Meeting, Milton Keynes, UK Presentation in KAIST-RIKEN-CAS joint symposium, Daejeon Lecture in Korea Institute of Science and Technology (KIST), Seoul Presentation in the Symposium of the Korean Society of Life Science, Gyeongju Lecture in Hamamatsu Medical School, Hamamatsu, Japan Lecture in GIST, Gwangju Presentation in the Symposium of the Japan Society of Mechanical Engineers, Tokyo, Japan Lecture in Tokyo Metropolitan University, Hino, Japan (Jan.8)

2015 7th Conference of Developmental Neurobiologists, Chuncheon, South Korea International Symposium of Korean Association for Laboratory Animal Science (KALAS), Incheon, South Korea

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College of Natural Science, Kyungpook National University, Daegu, South Korea 2013 Institute of Molecular Embryology and Genetics, Kumamoto, Japan 2012 Institut de recherches cliniques de Montreal, Montreal, Canada

117th Meeting of the Japanese Association of Anatomists, Kofu, Japan 2011 55th Symposium of the Japanese Society of Microscopy, Kagawa, Japan 2010 Keio University School of Medicine, Tokyo, Japan

2nd International Congress on Stem cells and Tissue Formation, Dresden, Germany Institute for Virus Research, Kyoto University, Kyoto, Japan European Molecular Biology Laboratory, Monterotondo, Italy Institute of Industrial Science, the University of Tokyo, Tokyo, Japan 2nd Meeting of Japanese Society for Quantitative Biology, Osaka, Japan

2009 Max-Planck-Institute for Molecular Biomedicine, Münster, Germany 61st Meeting of the Japan Society for Cell Biology, Nagoya, Japan Kawasaki Medical School, Kurashiki, Japan

King’s College London, London, UK 1st Caravan of Japanese Society for Quantitative Biology, Mishima, Japan

2008 INSERM-Institut du Fer a Moulin, Paris, France 7th ELSO International Meeting, Nice, France

The Italian Institute of Technology, Genova, Italy Organization of meetings 10/2013 Organizer of the 3rd German-Japanese Bilateral Meeting of Neurogenesis,

Sendai, Japan 09/2011 Organizer and chair, 55th Symposium of the Japanese Society of Microscopy,

Kagawa, Japan 07/2010 Organizer of the 2nd German-Japanese Bilateral Meeting of Neurogenesis,

Spreewald, Germany 09/2009 Organizer and chair, Symposium of the 32nd Annual Meeting of the Japan

Neuroscience Society, Nagoya, Japan 05/2007 Organizer of the 1st German-Japanese Bilateral Meeting of Neurogenesis,

Hakone, Japan Professional memberships 2004 – Japan Neuroscience Society, Japanese Society of Developmental Biologists,

Japanese Developmental Neuroscientists Regular reviewer for

Development, Molecular Biology of the Cell, Trends in Cell Biology, EMBO Report, Mechanism of Development, Stem Cells & Development, Stem Cell International, Development Growth & Differentiation, Journal of Visualized Experiments

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List of publications (*; corresponding authors, **; five representative papers)

Original articles (peer reviewed) Ettinger A, Kosodo Y, Huttner WB. (2017) Specific membrane dynamics during neural stem cell

division. Methods Cell Biol. 137:143-172 Kosodo Y*, Suetsugu T, Kobayashi TJ, Matsuzaki F. (2017) Systematic time-dependent

visualization and quantitation of the neurogenic rate in brain organoids. Biochem Biophy Res Commun 483:94-100.

Kobayashi T, Iwamoto Y, Takashima K, Isomura A, Kosodo Y, Kawakami K, Nishioka T, Kaibuchi

K, Kageyama R. (2015) Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation. FEBS J. 282(13):2475-87

**Iwashita M, Kataoka N, Toida K, and Kosodo Y*. (2014) Systematic profiling of spatiotemporal

tissue and cellular stiffness in the developing brain. Development, 141:3793-98 (with a highlighted article).

**Nagashima F, Suzuki IK, Shitamukai A, Sakaguchi H, Iwashita M, Kobayashi T, Tone S, Toida K,

Vanderhaeghen P, and Kosodo Y*. (2014) Novel and robust transplantation reveals the acquisition of polarized processes by cortical cells derived from mouse and human pluripotent stem cells. Stem Cells Dev, 23:2129-42 (cover)

**Kosodo Y*, Suetsugu T, Suda M, Mimori-Kiyosue Y, Toida K, Baba SA, Kimura A, and

Matsuzaki F*. (2011) Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain. EMBO J. 30:1690-1704. (with a highlighted article).

Kato TM, Kawaguchi A, Kosodo Y, Niwa H, Matsuzaki F (2010) Lunatic fringe potentiates Notch

signaling in the developing brain. Mol Cell Neurosci. 45:12-25. **Kosodo Y, Toida K, Dubreuil V, Alexandre P, Schenk J, Kiyokage E, Attardo A, Mora-Bermúdez

F, Arii T, Clarke JDW and Huttner WB (2008) Cytokinesis of neuroepithelial cells can divide their basal process before anaphase. EMBO J. 27:3151-63.

Fish JL#, Kosodo Y#, Enard W, Pääbo S and Huttner WB (2006) Aspm specifically maintains

symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci USA 103:10438-43. (#Joint first authors)

**Kosodo Y, Röper K, Haubensak W, Marzesco AM, Corbeil D and Huttner WB (2004)

Asymmetric distribution of the apical plasma membrane during neuron-generating division of mammalian neuroepithelial cells. EMBO J. 11:2314-24.

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Kosodo Y, Noda Y, Adachi H and Yoda K (2003) Cooperation of Sly1/SM-family protein and Sec18/NSF of Saccharomyces cerevisiae in disassembly of cis-SNARE membrane-protein complexes. Biosci Biotechnol Biochem 67:448-50.

Kosodo Y, Noda Y, Adachi H and Yoda K (2002) Binding of Sly1 to Sed5 enhances formation of

the yeast early Golgi SNARE complex. J Cell Sci 115:3683-91. Kosodo Y, Imai K, Hirata A, Noda Y, Takatsuki A, Adach H and Yoda K (2001) Multicopy

suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18:1003-14.

Kosodo Y, Noda Y and Yoda K (1998) Protein-Protein interactions of the yeast Golgi t-SNARE Sed5

protein distinct from its neural plasma membrane cognate Syntaxin 1. Biochem Biophy Res Commun 250:212-6.

Reviews (peer reviewed) Kawauchi T, Shikanai M and Kosodo Y. The extra-cell cycle regulatory functions of CDK proteins

and CDK inhibitors contribute to brain development and neurological disorders. (2013) Gene Cells. 18: 176-194

Kosodo Y*. Interkinetic nuclear migration: beyond a hallmark of neurogenesis (2012) Cell Mol Lif

Sci. 69: 2727-2738 Kosodo Y* and Huttner WB* (2009) The basal process and cell divisions of neural progenitors in

the developing brain. Dev Growth Differ 51, 251-61. Huttner WB and Kosodo Y (2005) Symmetric versus asymmetric cell division during neurogenesis

in the developing vertebrate central nervous system. Curr Opin Cell Biol 6:648-57. Book chapters Alexandra P, Clarke JDW, and Kosodo Y*. (2014) Asymmetric cell divisions and nuclear

migrations of neural progenitors: Two mechanisms that influence neurogenesis. In: Calegari F. and Wascow C. (eds.) “Stem Cells”. Science Publishers.

Dubreuil V, Farkas L, Calegari F, Kosodo Y and Huttner WB. (2005) Neurogenesis in the central

nervous system. In: Unsicker K. and Krieglstein K. (eds.) Cell signalling and growth factors in development. Wiley-VCH Publisher, Vol. 1 pp. 229-86.