CV May 2012 - CNR · - Director of NATO Advanced Study Institute on Sulfur-Centered Reactive Intermediates in Chemistry and Biology (June 1989) - Visiting Scientist (University of

Curriculum Vitae

Chryssostomos CHATGILIALOGLU

Biographical Sketch

Chryssostomos Chatgilialoglu (born 1952) is director

of research at the Consiglio Nazionale delle Ricerche

(Bologna) since 1991. He was the winner of the Fluka

Prize “Reagent of the Year 1990”. His research

interests lie in free radical reactions increasingly

addressed in the last decade to applications in

biomimetic chemistry and biomarkers discovery.

Author and editor of several books, including the 4

volumes of Encyclopedia of Radicals in Chemistry,

Biology and Materials published by Wiley in 2012. Author and co-author of over 240

papers, and invited speaker over 200 times at congresses and institutions. Supervisor of

international PhDs (>15) and post-doctorals (>30), including three Marie Curie Intra-

European Fellowships and two Marie Curie Research Training Networks. He was the

Chairman of COST Action CM0603 on Free Radicals in Chemical Biology (2007-2011)

and the Proposer of the new COST Action on Biomimetic Radical Chemistry (2012-

2016). He is President and co-founder of the spin-off company Lipinutragen.

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Contents Page

Short Curriculum Vitae 3

Research Activity 6

Research Quality 11

Reagent of the Year 1990 12

Publications in Journals 13

Publications in Books 46

Publications in Magazines and Online Resources 51

Publications as Meeting Abstract 53

Editorial Activities for Scientific Journals 55

Books 56

Patents 58

Conference and Visiting Activity 59

Invited Lectures at Congresses and Meetings 60

Invited Lectures at Institutions 72

Visiting Scientist at Foreign Istitutions 85

Managerial activity 87

International Appointments 91

Consulting Activity 95

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Short Curriculum Vitae Surname: Chatgilialoglu

First name: Chryssostomos

Date and place of birth: Nikea (Greece), 11-11-1952

Citizenship: Greek and Italian

Affiliation and official address: ISOF - Consiglio Nazionale delle Ricerche (CNR),

Via Piero Gobetti 101, 40129 Bologna, Italy

phone: +39-0516398309

fax.: +39-0516398349

e-mail: [email protected]

http://www.isof.cnr.it/biofreeradicals/Home.html

Education

Laurea in Chimica Industriale (1976), University of Bologna

Career/Employment (employers, position, and dates)

University of York (UK) Postdoctor 1977-1979

National Research Council of Canada (Ottawa) Research Associate 1979-1982

Consiglio Nazionale delle Ricerche (Bologna) Professore Visitatore 1983-1985

Consiglio Nazionale delle Ricerche (Bologna) Ricercatore 1985-1991

Consiglio Nazionale delle Ricerche (Bologna) Dirigente di Ricerca 1991-

Specialties, Activities

Research:

- Free radical chemistry

- Chemical biology

- Radiation studies of biomolecular systems

- Omics of cell radical stress and related biomarkers

- Molecular design based on radical reactivity and biomimetic models

Management:

- Leader of BioFreeRadicals Group at ISOF, CNR

- Responsible of European and International projects

- President and co-founder of the spin-off company Lipinutragen srl

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Honours, Fellowships, Awards

- S.R.C. Postdoctoral Fellowship 1977 – 1979

- Visiting Scientist (National Research Council of Canada, summer 1986)

- Director of NATO Advanced Study Institute on Sulfur-Centered Reactive

Intermediates in Chemistry and Biology (June 1989)

- Visiting Scientist (University of Basel, February – July 1990)

- Fluka prize (Reagent of the Year 1990)

- NATO senior Fellowship (1991)

- Director of NATO Advanced Study Institute on Chemical Synthesis: Gnosis to

Prognosis (May 1994)

- Wilsmore Fellow (University of Melbourne, Australia, November 1999 – January

2000).

- Visiting Professor at Universitè Pierre et Marie Curie, France (April 2000)

- Guest Editor of Helvetica Chimica Acta (October 2006)

- Chair of COST Action CM0603: Free Radical in Chemical Biology (June 2007 –

June 2011)

- Visiting Professor at Ludwig-Maximilians-Universität München, Germany

(March, May and June 2008)

- Guest Editor of CHIMIA (September 2008)

- Visiting Professor at Universitè Pierre et Marie Curie, France (June 2009)

- The Cheves Walling Lecture 2009

- Chairman of the EUCHEM Conference on “Organic Free Radicals”, Bologna, 28

June - 2 July 2010

- Member of Editorial Board of Journal of Glycomics and Lipidomics since 2011.

- Co-Editor of the Encyclopedia of Radicals in Chemistry, Biology and Materials (4

volumes, 73 chapters, 2300 pages), 2012 John Wiley & Sons, Ltd.

- Proposer of COST Action CM01203: Biomimetic Radical Chemistry (Sept 2012 –

Sept 2016)

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Publications

- Number of papers: 240 (212 in refereed Journals + 32 chapters in Books)

- Books: 6 (2 as author and 4 edited)

- Patents: 6

- Citations: > 6300 (h-index = 38)

Conferences and Seminars

- Invited speaker at congresses: 90

- Invited speaker at institutions: 114

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Research Activity

The research activity of Dr. Chatgilialoglu concerns the theme of free radical chemistry,

embracing the structure-reactivity relationship of free radicals and their various

applications in synthetic methodologies, material science, and life sciences. The thus

acquired wide competence on free radical chemistry has been achieved and developed by

an interdisciplinary approach, using the fundamental knowledge of organic and physical

chemistry as basis for an extension into the fields of synthetic, bioorganic and biological

chemistry.

The scientific activity is presented here below in a chronological order from 1977 to

date, and pertains to the following fields:

- Physical Organic Chemistry;

- Synthetic Methodologies;

- Polymeric Materials;

- Biomimetic Chemistry for Technological Applications.

Physical Organic Chemistry

The studies in physical organic chemistry were predominant in the first ten years.

During this period Dr. Chatgilialoglu worked as post-doctoral fellow at the University of

York (England) in the group of Prof. R. O. C. Norman. Immediately after he served as

Research Associate for three years at the National Research Council of Canada (Ottawa)

with Prof. K. U. Ingold. The numerous publications of this period deal with studies of

organic and organometallic free radicals using laser flash photolysis and electron

paramagnetic resonance techniques, assisted by other analytical techniques, such as mass

spectrometry and nuclear magnetic resonance, and combined with theoretical and

synthetic models. The knowledge of kinetic methodologies and time-resolved

spectroscopies constituted a solid background for the expansion of his scientific activity.

In particular, the following subjects have been studied:

(i) Structural properties and reactivity of sulfur-centered and nitrogen-centered

reactive species.

(ii) Group 14 atom-centered radicals (Si, Ge, Sn). Within this topic the most

relevant result was the determination of absolute rate constants and Arrhenius

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parameters for the reaction of alkyl radicals with Group 14 metal hydrides by

means of laser flash photolysis. These data allowed, in particular, to examine

the reactivity of tributyltin hydride, that is a radical-based reagent largely

employed in organic chemistry, and to put the basis for the proposal of silicon

hydrides as an important class of reducing agents.

(iii) Implementation of techniques for the acquisition of kinetic data (e.g., radical

clock methodology). The reactivity of several alkyl and aryl carbon-centered

radical species has been studied in the presence of hydrogen atom donors,

such as silicon or germanium hydrides and thiols. The radical cyclization

reaction has also been studied and applied in radical cascade synthetic

strategies starting from alkyl and acyl radicals.

(iv) Chemical radiation studies in the last decade of the research activity using

gamma-irradiation and pulse radiolysis, for the individuation of fundamental

chemical mechanisms, such as the tautomerization of one-electron oxidation

of DNA bases, selective generation of radical centers on DNA sugar moieties

and free radical reactivity of lipids and proteins.

Free radical chemistry has become an important tool for organic synthesis, and its

success is mostly due to the basic work concerning free radical reactivity. In this respect,

the contribution given by Dr. Chatgilialoglu to fundamental discoveries and knowledge in

free radical chemistry is widely recognized in the scientific community at international

level.

Synthetic Methodologies

Starting from the late nineteen-eighties, studies in synthetic methodologies have been

carried out, focusing in particular on two subjects: radical-based reducing agents and

innovative radical-based synthetic strategies.

The studies on Group 14 hydride reactivity carried out in the previous years

highlighted a variety of triorganosilanes as interesting reducing agents in a free radical

mechanism. In fact, one of them, namely, tris(trimethylsilyl)silane was introduced as a

very versatile compound for carrying out several types of radical reactions, from

functional group reduction to deoxygenation, carbon-carbon bond formation, cyclization,

etc. This was an important discovery in a period when the reagent of choice for radical

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reduction was tributyltin hydride, which in the environment and particularly in humans

exhibits a strong toxicity. The regio-, chemo- and stereoselectivities of this reagent were

thoroughly investigated. For his achievements in this field Dr. Chatgilialoglu received the

prestigious Fluka prize “Reagent of the Year 1990” (see page 11). More than 1000

publications in chemical research deal with the use of this reagent from groups all over

the world. In the following years the class of organosilanes has been investigated

systematically, combining kinetic studies with synthetic applications, so that a complete

overview of the characteristics and applicability of the different silanes is now available.

Today, Dr. Chatgilialoglu is considered one of the most expert scientists in radical

reactivity of organosilanes. He is author of reviews on this subject, which appeared in the

most prestigious international scientific journals. He is also author of the book

“Organosilanes in Radical Chemistry” published by Wiley in 2004.

The scientific activity of the last 15-years was focused to synthetic strategies for

efficient, selective and environmental-friendly processes. During these studies, radical

chemistry has been successfully coupled with ionic processes. Elegant and efficient

syntheses have been realized for the preparation of molecular libraries of modified

nucleosides, lipids and proteins, which attract strong academic and industrial interests,

applicable to diverse fields, from biology and pharmacology to bio- and nanotechnology.

In the area of the macromolecule reactivity, the interest has been focused on free

radical mechanisms involving DNA and lipids. These macromolecules have received

attention from researchers from different fields, due to their peculiar molecular and

supramolecular characteristics that allow applications in biology and biotechnology fields

to be envisaged. In particular, Dr. Chatgilialoglu was the first to study the mechanism of

ribonolactone moiety and the formation of purine cyclonucleosides, which have been

further implemented in the area of biomimetic radical chemistry for technological

applications. The radical-based approach also involved phospholipids with the discovery

of thiyl radical catalyzed isomerization of unsaturated fatty acids. This reaction has been

applied to supramolecular organized systems such as liposomes, which have been then

implemented for biomimetic chemistry. The cis-trans isomerization has been thoroughly

studied in various conditions, establishing the effects of various factors (oxygen,

antioxidants, solvents) on the outcome. It is important to note that this conversion

changes deeply the properties of the lipid molecules, therefore, it becomes an important

tool for bio- and nano-technological applications. For example, in case of triglycerides,

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the isomerization can be useful to change the physical properties of oils, thus affording

new materials for various applications.

The experience in nucleoside and lipid chemistry led to the development of synthetic

processes in an aqueous environment. This is an ongoing project in Dr. Chatgilialoglu’s

group and it includes the “on water” methodology, where the effect of heterogeneous

systems coupled with the supramolecular organization of substrates can play an important

role for enhancing some selectivity features. The use of tris(trimethylsilyl)silane as

reagent in water was developed in this context.

Polymeric Materials

A further interdisciplinary research deals with polymeric materials, in particular with

the modification of commercially available polymers involving radical chemistry. This is

a field of enormous industrial interest, and Dr. Chatgilialoglu has been consultant for

important companies due to his well-known reputation as free radical expert. In

collaboration with the EniChem Company (Milan, Italy) the process of radical

carbonylation of 1,4-cis-polybutadiene was studied, and realized under mild conditions of

low temperature and moderate pressure. The formation and reactivity of an important

radical intermediate and the crucial species for the reaction mechanism, namely, the acyl

radical, was studied in detail. Since the polymer characteristics are driven by the

cyclization modes occurring in the material, the cyclization was also studied with several

appropriately synthesized monomeric models.

Dr. Chatgilialoglu was also consultant for six years of Ciba Geigy Ltd (Basel,

Switzerland) for organosilane chemistry. The research carried out on the oxidative

behavior of poly(hydrosilanes) highlighted the antioxidant activity of these chemicals and

the use as process stabilizers in the polyolefin extrusion, that has been world-patented.

Biomimetic Chemistry for Technological Applications

In the last decade the scientific activity has been increasingly addressed to the field of

radical processes under biomimetic conditions, as an extension of the previously

described synthetic and mechanistic studies on biomolecules. With a solid background on

physical organic chemistry and free radical reactivity, Dr. Chatgilialoglu has effectively

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contributed to the development of free radicals for nano- and bio-technological

applications, evaluating the effects of biomolecules such as DNA, proteins and lipids,

having specific supramolecular structures in aqueous systems. In particular, his approach

is to design biomimetic models which allow for a systematic study of all possible factors

influencing the reactivity of these macro- and supra-molecular systems, including

analytical protocols and complete characterization of reaction or transformation products.

The reactivity, as well as the library of products derived from the models, are an

important basis for starting bio- and nano-technological applications. An immediate

application of these achievements can be done in life sciences, due to the biological

impact of DNA and lipid molecules being involved in the free radical stress of

biosystems. Here we mention two processes which are promising for technological

development: the electron excess transfer in double stranded DNA and telomeric G-

quadruplex, and the liposome cis-trans isomerization.

It is also important to evidence the connection of these studies with the

implementation of a strong analytical platform, made by molecular libraries and protocols

for the separation and characterization of a large variety of new biomolecular structures

including their properties. These libraries can have an enormous impact for a chemical

biology approach in the fields of proteomics, genomics and lipidomics, where the

knowledge of radical reactions and mechanisms can contribute to the understanding of

still unknown molecular bases for bio- and nano-technological applications.

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Research Quality

The quality of the research activity represents a strong commitment in the carrier of Dr.

Chatgilialoglu, either in the optimization of the research results to gain a firm leadership

in chemical sciences and in the choice of high impact subjects for attracting interest from

the scientific community. As a representative example Figure 1 shows that 84

publications out of 212 (40%) have been published in journals of the American Chemical

Society, which are well known for the accurate selection of the best subjects and the

severe peer review process. In particular, the four review articles published in Accounts of

Chemical Research and Chemical Reviews testify the international recognition given to

his research; the high number of papers appeared in the Journal of the American

Chemical Society represents an indirect measure of the interest of a general chemical

audience to the research subjects. The graphic also shows the wide range of chemical

publications in specialized areas going from physical chemistry to organic chemistry and

chemical biology.

It is worth underlining the many scientific international collaborations of Dr.

Chatgilialoglu. He developed an expertise on free radical chemistry able to communicate

with a large variety of scientists. This experience has also allowed him to gather scientists

in free radical research, becoming an important reference person for this community, as

testified by the chairmanship of two COST Actions and the editing of the Encyclopedia

on Free Radicals in Chemistry, Biology and Materials published in 2012 by Wiley.

0 5

10 15 20 25 30

Figure 1. 84 Pubblications in ACS journals

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Publications in Journals

Year 2012 (first five months)

205) Recent applications of the (TMS)3SiH radical-based reagent

Chatgilialoglu, C.; Lalevée, J.

Molecules 2012, 17, 527–555.

206) Revisiting the reaction of hydroxyl radicals with vicinal diols in water

Jiang, D.; Barata-Vallejo, S.; Golding, B. T.; Ferreri, C.; Chatgilialoglu, C.

Org. Biomol. Chem. 2012, 10, 1102–1107.

207) Rat liver mitochondrial membrane characteristics and mitochondrial functions are

more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect

of different nutritional lipid patterns

Aoun, M; Feillet-Coudray, C.; Fouret, G.; Chabi, B. Crouzier, D.; Ferreri, C.;

Chatgilialoglu, C.; Cabello, C.; Cristol, J. P.; Carbonneau, M.-A.; Coudray, C.

Br. J. Nutr. 2012, 107, 647–659.

208) Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection

in rats fed a deodorized fish oil diet

Ferreri, C.; Grabovskiy, S.; Aoun, M.; Melchiorre, M.; Kabal’nova, N.; Feillet-

Coudray, C.; Fouret, G.; Coudray, C.; Chatgilialoglu, C.

Chem. Res. Toxicol. 2012, 25, 687–694.

209) Biomimetic Models of Radical Stress and Related Biomarkers

Chatgilialoglu, C.; Ferreri, C.; Masi, A.; Melchiorre, M.; Sansone, A.; Terzidis, M.

A.; Torreggiani, A.

Chimia 2012, 66, 368–371.

210) Investigation of reactions postulated to occur during inhibition of ribonucleotide

reductases by 2'-azido-2'-deoxynucleotides

Dang, T. P.; Sobczak, A. J.; Mebel A.; Chatgilialoglu, C.; Wnuk, S. F.

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Tetrahedron 2012, 68, in press (doi:101016/j.tet.2012.04.050)

211) trans Arachidonic acid isomers inhibits NADPH-oxidase activity by direct

interaction with enzyme components

Souabni, H.; Thoma, V.; Bizouarn, T.; Chatgilialoglu, C.; Siafaka-Kapadai, A.;

Baciou, L.; Ferreri, C.; Houée-Lévin, C.; Ostuni, M.A.

Biochim. Biophys. Acta - Biomembr. 2012, 1818, in press (doi:

101016/j.bbamem.2012.04.018)

212) The role of functional lipidomics and the development of molecular diagnostic tools

Chatgilialoglu, C.; Ferreri, C.

Expert Rev. Mol. Diagn. 2012, 12, in press.

Year 2011

195) Investigation of excess electron transfer in DNA double-duplex systems allows

estimation of absolute excess electron transfer and CPD cleavage rates

Fazio, D.; Trindler, C.; Heil, K.; Chatgilialoglu, C.; Carell, T.

Chem. Eur. J. 2011, 17, 206–212.

196) Human serum albumin modifications associated with reducing radical stress

Salzano, A. M.; Renzone, G.; Scaloni, A.; Torreggiani, A.; Ferreri, C.;

Chatgilialoglu, C.

Mol. BioSyst. 2011, 7, 889–898.

197) Purine 5’,8-cyclonucleoside lesions: chemistry and biology

Chatgilialoglu, C.; Ferreri, C.; Terzidis, M. A.

Chem. Soc. Rev. 2011, 40, 1368–1382.

198) Radical-based alkylation of guanine derivatives in aqueous medium

Chatgilialoglu, C.; Caminal, C.; Mulazzani, Q. G.

Org. Biomol. Chem. 2011, 9, 3494–3498.

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199) Linoleic acid peroxidation vs cis–trans isomerization: a biomimetic model of free

radical reactivity in the presence of thiols

Mihaljević, B.; Tartaro, I.; Ferreri, C.; Chatgilialoglu, C.

Org. Biomol. Chem. 2011, 9, 3541–3548.

200) Combined Raman and IR spectroscopic studies on the radical-based modifications

of methionine

Torreggiani, A.; Barata-Vallejo, S.; Chatgilialoglu, C.

Anal. Bioanal. Chem. 2011, 401, 1231–1239.

201) Lipid markers of geometrical radical stress: synthesis of mono-trans cholesteryl

esters isomers and detection in human plasma

Melchiorre, M.; Torreggiani, A.; Chatgilialoglu, C.; Ferreri, C.

J. Am. Chem. Soc. 2011, 133, 15184–15190.

202) Radiation-induced reductive modifications of sulfur-containing amino acids within

peptides and proteins

Chatgilialoglu, C.; Ferreri, C.; Torreggiani, A.; Renzone, G.; Salzano, A. M.;

Scaloni, A.

J. Proteomics 2011, 74, 2264–2273.

203) Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin

secretion

Cohen, G.; Riahi, Y.; Shamni, O.; Guichardant, M.; Chatgilialoglu, C.; Ferreri, C.;

Kaiser, N.; Sasson, S.

Diabetes 2011, 60, 2830–2842.

204) New insights into the reaction paths of hydroxyl radicals with 2’-deoxyguanosine

Chatgilialoglu, C.; D’Angelantonio, M.; Kciuk, G.; Bobrowski, K.

Chem. Res. Toxicol. 2011, 24, 2200–2206.

Year 2010

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190) One-electron-reduction of 8-bromoisoguanosine and 8-bromoxanthosine in the

aqueous phase: sequential versus concerted proton-coupled electron routes

Chatgilialoglu, C.; D’Angelantonio, M.; Kaloudis, P.; Mulazzani, Q. G.; Guerra, M.

J. Phys. Chem. Lett. 2010, 1, 174–177.

191) Radiation chemical studies of methionine in aqueous solution: understanding the

role of molecular oxygen

Barata-Vallejo, S.; Ferreri, C.; Postigo, A.; Chatgilialoglu, C.

Chem. Res. Toxicol. 2010, 23, 258–263.

192) Separation of cis/trans geometrical fatty acid isomers by silver-exchanged zeolite Y

Lykakis, I. N.; Ferreri, C.; Grabovskiy, S. A.; Chatgilialoglu, C.

Tetrahedron 2010, 66, 2203–2209.

193) Radiation-induced formation of purine 5',8-cyclonucleosides in isolated and cellular

DNA: high stereospecificity and modulating effect of oxygen

Belmadoui, N.; Boussicault, F.; Guerra, M.; Ravanat, J. L.; Chatgilialoglu, C.;

Cadet, J.

Org. Biomol. Chem. 2010, 8, 3211–3219.

194) Base-promoted reaction of 5-hydroxyuracil derivatives with peroxyl radicals

Amorati, R.; Valgimigli, L.; Pedulli, G. F.; Grabovskiy, S. A.; Kabal’nova, N. N.;

Chatgilialoglu, C.

Org. Lett. 2010, 12, 4130–4133.

Year 2009

184) Reaction of hydrated electrons with guanine derivatives: tautomerism of

intermediate species

D’Angelantonio, M.; Russo, M.; Kaloudis, P.; Mulazzani, Q. G.; Wardman, P.;

Guerra, M.; Chatgilialoglu, C.

J. Phys. Chem. B 2009, 113, 2170–2176.

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185) A reevaluation of the ambident reactivity of guanine moiety towards hydroxyl

radicals

Chatgilialoglu, C.; D’Angelantonio, M.; Guerra, M.; Kaloudis, P.; Mulazzani, Q. G.

Angew. Chem. Int. Ed. 2009, 48, 2214–2217.

186) Rate constants and transition state geometry of reactions of alkyl, alkoxyl and

peroxyl radicals with thiols

Denisov, E. T.; Chatgilialoglu, C.; Shestakov, A. F.; Denisova, T. G.

Int. J. Chem. Kinet. 2009, 41, 284–293.

187) Hydrosilylation reactions of C-C multiple bonds using (Me3Si)3SiH in water.

Comparative study of the radical initiation step

Postigo, A.; Kopsov, S.; Zlotsky, S. S.; Ferreri, C.; Chatgilialoglu, C.

Organometallics 2009, 28, 3282–3287.

188) Zinc and cadmium complexes of a plant metallothionein under radical stress:

desulfurisation reactions associated with the formation of trans lipids in model

membranes

Torreggiani, A.; Domènech J.; Ferreri, C.; Orihuela, R.; Atrian, S.; Capdevila, M.;

Chatgilialoglu, C.

Chem. Eur. J. 2009, 15, 6015–6024.

189) Comparison of isoelectronic 8-HO-G and 8-NH2-G derivatives in redox processes

Kaloudis, P.; D’Angelantonio, M.; Guerra, M.; Spadafora, M.; Cismas, C.; Gimisis,

T.; Mulazzani, Q. G.; Chatgilialoglu, C.

J. Am. Chem. Soc. 2009, 131, 15895–15902.

Year 2008

171) Fatty acids profile of erythrocyte membranes as possible biomarker of longevity

Puca, A. A.; Andrew, P.; Novelli, V.; Viviani, C.; Somalvico, F.; Cirillo, N. A.;


Rejuv. Res. 2008, 11, 63–72.

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172) Solar one-way photoisomerisation of 5’,8-cyclo-2’-deoxyadenosine

Jimenez, L. B.; Encinas, S.; Chatgilialoglu, C.; Miranda, M. A.

Org. Biomol. Chem. 2008, 6, 1083–1086.

173) (Me3Si)3SiH: Twenty years after its discovery as a radical-based reducing agent

Chatgilialoglu, C.

Chem. Eur. J. 2008, 14, 2310–2320.

174) Lipid metabolism and diet: Possible mechanisms of slow aging

Puca, A.; Chatgilialoglu, C.; Ferreri, C.

Int. J. Biochem. Cell B. 2008, 40, 324–333.

175) One-electron reduction of 8-bromo-2-aminoadenosine in the aqueous phase:

Radiation chemical and DFT studies of the mechanism

Kaloudis, P.; D’Angelantonio, M.; Guerra, M.; Gimisis, T.; Mulazzani, Q. G.;

Chatgilialoglu, C.

J. Phys. Chem. B 2008, 112, 5209–5217.

176) The reductive desulfurization of Met and Cys residues in bovine RNAse A

associated with the trans lipid formation in a mimetic model of biological

membranes

Ferreri, C.; Chatgilialoglu, C.; Torreggiani, A.; Salzano, A. M.; Renzone, G.;

Scaloni, A.

J. Proteome Res. 2008, 7, 2007–2015.

177) The Fate of C5’ Radicals of Purine Nucleosides Under Oxidative Conditions

Boussicault, F.; Kaloudis, P.; Caminal, C.; Mulazzani, Q. G.; Chatgilialoglu, C.

J. Am. Chem. Soc. 2008, 130, 8377–8385.

178) Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with

dual effects on rabbit platelet activation

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Ferreri, C.; Anagnostopoulos, D.; Lykakis, I. N.; Chatgilialoglu, C.; Siafaka-

Kapadai, A.

Bioorg. Med. Chem. 2008, 16, 8359–8365.

179) Silyl radicals in chemical synthesis

Chatgilialoglu, C.; Timokhin, V. I.

Adv. Organomet. Chem. 2008, 57, 117–181.

180) Biologically Relevant Small Radicals

Bauer, G.; Chatgilialoglu, C.; Gebicki, J. L.; Gebicka, L.; Gescheidt, G.; Golding,

B. T.; Goldstein, S.; Kaizer, J.; Merenyi, G.; Speier, G.; Wardman, P.

Chimia 2008, 62, 704–712.

181) Lipidomics and Free Radical Modifications of Lipids

Chatgilialoglu, C.; Ferreri, C.; Hermetter, A.; Lacote, E.;

Mihaljević, B.;

Nicolaides,

A.; Siafaka –Kapadai, A.

Chimia 2008, 62, 713–720.

182) Biomimetic chemistry on tandem protein/lipid damages under reductive radical

stress

Atrian, S.; Bobrowski, K.; Capdevila, M.; Chatgilialoglu, C.; Ferreri, C.; Houée-

Levin, C.; Salzano, A. M.; Scaloni, A.; Torreggiani, A.

Chimia 2008, 62, 721–727.

183) DNA damage and radical reactions: mechanistic aspects, formation in cells and

repair studies

Cadet, J. Carell, T.; Cellai, L.; Chatgilialoglu, C.; Gimisis, T.; Miranda, M.; O'Neill,

P.; Ravanat, J.-L.; Robert, M.

Chimia 2008, 62, 742–749.

Year 2007

162) Reaction of Hydrogen Atom with Met-Enkephalin and Related Peptides

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Mozziconacci, O.; Bobrowski, K.; Ferreri, C.; Chatgilialoglu, C.

Chem. Eur. J. 2007, 13, 2029–2033.

163) Sulfhydryl Radical (HS•/S•–): A Contender for the Isomerization of Double Bonds in

Membrane Lipids

Lykakis, I. N.; Ferreri, C.; Chatgilialoglu, C.

Angew. Chem. Int. Ed. 2007, 46, 1914–1916.

164) Independent Generation of C-5’ Nucleosidyl Radicals in Thymidine and 2’-

Deoxyguanosine

Manetto, A.; Georganakis, D.; Gimisis, T.; Leondiadis, L.; Mayer, P.; Carell, T.;

Chatgilialoglu, C.

J. Org. Chem. 2007, 72, 3659–3666.

165) One-Electron Reduction of Methanesulfonyl Chloride. The Fate of (MeSO2Cl)•– and

MeSO2• Intermediates in Oxygenated Solutions and Their Role in the cis-trans

Isomerization of Monounsaturated Fatty Acids

Tamba, M.; Dajka, K.; Ferreri, C.; Asmus, K.-D.; Chatgilialoglu, C.

J. Am. Chem. Soc. 2007, 129, 8716–8723.

166) Radical Carbonylation with [11C]Carbon Monoxide Promoted by Oxygen-Centered

Radicals: Experimental and DFT Studies of the Mechanism

Itsenko, O.; Norberg, D.; Rasmussen, T; Långström, B.; Chatgilialoglu, C.

J. Am. Chem. Soc. 2007, 129, 9020–9031.

167) Trans Fatty Acids in Membranes: The Free Radical Path

Ferreri, C.; Panagiotaki, M.; Chatgilialoglu, C.

Mol. Biotechnol. 2007, 37, 19–25.

168) Ring-Opening of the Cyclobutane in Thymine Dimer Radical Anion

Chatgilialoglu, C.; Guerra, M.; Kaloudis, P.; Houée-Lévin, C.; Marignier, J.-L.;

Swaminathan, V. N.; Carell, T.

Chem. Eur. J. 2007, 13, 8979–8984.

21

169) Radical Reactions in Aqueous Medium Using (Me3Si)3SiH

Postigo, A.; Kopsov, S.; Ferreri, C.; Chatgilialoglu, C.

Org. Lett. 2007, 9, 5159–5162.

170) (5’S)- and (5’R)-5’,8-Cyclo-2’-deoxyguanosine: Mechanistic Insights on the 2'-

Deoxyguanosin-5'-yl radical Cyclization

Chatgilialoglu, C.; Bazzanini, R.; Jimenez, L. B.; Miranda, M. A.

Chem. Res. Toxicol. 2007, 20, 1820–1824.

Year 2006

148) Investigation of Radical-Based Damage of RNase A in Aqueous Solutions and

Lipid Vesicles

Torreggiani, A.; Tamba, M.; Manco, I.; Faraone-Mennella, M. R.; Ferreri, C.;

Chatgilialoglu, C.

Biopolymers 2006, 81, 39–50.

149) Complex Sequence Dependence by Excess Electron Transfer Through DNA with

Different Strength Electron Acceptors

Manetto, A.; Breeger, S.; Chatgilialoglu, C.; Carell, T.

Angew. Chem. Int. Ed. 2006, 44, 318–321.

150) A Facile One-Pot Synthesis of 8-Oxo-7,8-dehydro-(2’-deoxy)adenosine in Water

Chatgilialoglu, C.; Navacchia, M. L.; Postigo, A.

Tetrahedron Lett. 2006, 47, 711–714.

151) Probing the Influence of cis-trans Isomers on Model Lipid Membrane Fluidity Using

cis-Parinaric Acid and a Stop-Flow Technique

Ferreri, C.; Pierotti, S.; Chatgilialoglu, C.; Barbieri, A.; Barigelletti, F.

Chem. Commun. 2006, 529–531.

22

152) Comparison of Phosphatidylcholine Vesicle Properties Related to Geometrical

Isomerism

Ferreri, C.; Pierotti, S.; Barbieri, A.; Zambonin, L.; Landi, L.; Rasi, S.; Luisi, P. L.;

Barigelletti, F.; Chatgilialoglu, C.

Photochem. Photobiol. 2006, 82, 274–280.

153) Reductive Modification of Methionine Residue in Amyloid–β Peptide

Kadlcik, V.; Sicard-Roselli, C.; Houée-Levin, C.; Kodicek, M.; Ferreri, C.;

Chatgilialoglu, C.

Angew. Chem. Int. Ed. 2006, 45, 2595–2598.

154) Occurrence of Trans Fatty Acids in Rats Fed a Trans-Free Diet: A Free Radical-

Mediated Formation?

Zambonin, L.; Ferreri, C.; Cabrini, L.; Prata, C.; Chatgilialoglu, C.; Landi, L.

Free Radical Biol. Med. 2006, 40, 1549–1556.

155) C5’-Adenosinyl Radical Cyclization. A Stereochemical Investigation

Navacchia M. L.; Chatgilialoglu, C.; Montevecchi, P. C.

J. Org. Chem. 2006, 71, 4445–4452.

156) Trans Fatty Acids and Radical Stress: What Are the Real Culprits?

Chatgilialoglu, C.; Ferreri, C.; Lykakis, I. N.; Wardman, P.

Bioorg. Med. Chem. 2006, 14, 6144–6148.

157) Chemical Radiation Studies of 8-Bromo-2’-deoxyinosine and 8-Bromoinosine in

Aqueous Solutions

Russo, M.; Jimenez, L. B.; Mulazzani, Q. G.; D’Angelantonio, M.; Guerra, M.;

Miranda, M. A.; Chatgilialoglu, C.

Chem. Eur. J. 2006, 12, 7684–7693.

158) Tautomerism in the Guanyl Radicals

Chatgilialoglu, C.; Caminal C.; Altieri, A.; Vougioukalakis, G. C.; Mulazzani, Q.

G.; Gimisis, T.; Guerra, M.;

23

J. Am. Chem. Soc. 2006, 128, 13796–13805.

159) Epoxidation of Polyunsaturated Fatty Acid Double Bonds by Dioxirane Reagent:

Regioselectivity and Lipid Supramolecular Organization

Grabovskiy, S. A.; Kabal’nova, N. N.; Chatgilialoglu, C.; Ferreri, C.

Helv. Chim. Acta 2006, 89, 2243–2253.

160) The tris(trimethylsilyl)silane/thiol reducing system: A tool for measuring rate

constants for reactions of carbon-radicals with thiols

Chatgilialoglu, C.

Helv. Chim. Acta 2006, 89, 2387–2398.

161) The Reaction of Hydrogen Atoms with Methionine Residues: A Model of

Reductive Radical Stress Causing Tandem Protein-Lipid Damage

Ferreri, C.; Manco, I.; Faraone-Mennella, M. R.; Torreggiani, A.; Tamba, M.;

Manara, S.; Chatgilialoglu, C.

ChemBioChem 2006, 7, 1738–1744.

Year 2005

135) Reactions of Oxide Radical Ion (O•–) with Pyrimidine Nucleosides

Chatgilialoglu, C.; Ioele, M.; Mulazzani, Q. G.

Radiat. Phys. Chem. 2005, 72, 251–256.

136) The Kinetics of Z/E Isomerization of Methyl Oleate, Catalyzed by Photogenerated

Thiyl Radicals

Chatgilialoglu, C.; Samadi, A.; Guerra, M.; Fischer, H.

ChemPhysChem 2005, 6, 286–291.

137) The Reaction of Benzothiazole Sulfenamide with (TMS)3SiH: An Example of

Degenerated-Branched Chain Process

Varlamov, V. T.; Ferreri, C.; Chatgilialoglu, C.

J. Organomet. Chem. 2005, 690, 1756–1762.

24

138) Trans Lipids Formation Induced by Thiols in Human Monocytic Leukemia Cells

Ferreri, C.; Kratzsch, S.; Brede, O.; Marciniak, B.; Chatgilialoglu, C.

Free Radic. Biol. Med. 2005, 38, 1180–1187.

139) Radiation Damage of Lysozyme in a Biomimetic Model: Some Insights by Raman

Spectroscopy

Torreggiani, A.; Tamba, M.; Manco, I.; Faraone-Mennella, M. R.; Ferreri, C.;

Chatgilialoglu, C.

J. Mol. Struct. 2005, 744, 767–773.

140) Synthesis of All-trans Isomer of Arachidonic Acid and Its Effect on Rabbit Plateled

Aggregation

Anagnostopoulos, D.; Ferreri, C.; Samadi, A.; Chatgilialoglu, C.; Siafaka-Kapadai,

A.

Bioorg. Med. Chem. Lett. 2005, 15, 2766–2770.

141) The Influence of Solid–State Molecular Organization on the Reaction Paths of Thiyl

Radicals: EPR Experimental Evidence for Radiation Induced Reactions in

Clathrates, Polymer Matrices and Lysozyme

Faucitano, A.; Buttafava, A.; Mariani, A.; Chatgilialoglu, C.

ChemPhysChem 2005, 6, 1100–1107.

142) Trans Lipids: The Free Radical Path


Acc. Chem. Res. 2005, 38, 441–448.

143) Trans Fatty Acid and Atopic Eczema/Dermatitis Syndrome: The Relationship with a

Free Radical cis—trans Isomerization of Membrane Lipids

Ferreri, C.; Angelini, F.; Chatgilialoglu, C.; Dellonte, S.; Moschese, V.; Rossi, P.;

Chini, L.

Lipids 2005, 40, 661–667.

25

144) Tautomers of One-Electron Oxidized Guanosine

Chatgilialoglu, C.; Caminal C.; Guerra, M.; Mulazzani, Q. G.

Angew. Chem. Int. Ed. 2005, 44, 6030–6032.

145) Geometrical Trans Lipid Isomers: A New Target for Lipidomics

Ferreri, C.; Chatgilialoglu, C.

ChemBioChem 2005, 6, 1722–1734.

146) Radical Cyclization Approach to Cyclonucleosides

Navacchia, M. L.; Manetto, A.; Montevecchi, P. C.; Chatgilialoglu, C.

Eur. J. Org. Chem. 2005, 4640–4648.

147) The Radical-Based Reduction with (TMS)3SiH “on Water”

Postigo, A.; Ferreri, C.; Navacchia, M. L.; Chatgilialoglu, C.

Synlett 2005, 2854–2856.

Year 2004

123) Regioselective Cis-Trans Isomerization of Arachidonic Double Bonds by Thiyl

Radicals: The Influence of Phospholipid Supramolecular Organization

Ferreri, C.; Samadi, A.; Sassatelli, F.; Landi, L.; Chatgilialoglu, C.

J. Am. Chem. Soc. 2004, 126, 1063–1072.

124) Selective Generation and Reactivity of 5'-Adenosinyl and 2'-Adenosinyl Radicals

Chatgilialoglu, C.; Duca, M.; Ferreri, C.; Guerra, M.; Ioele, M.; Mulazzani, Q. G.;

Strittmatter, H.; Giese, B.

Chem. Eur. J. 2004, 10, 1249–1255.

125) Thermal Decomposition of tert-Butyl Perester of Thymidine-5’-carboxylic Acid.

Formation and Fate of the Pseudo C4’ Radical

Montevecchi, P. C.; Manetto, A.; Navacchia, M. L.; Chatgilialoglu, C.

Tetrahedron 2004, 60, 4303–4308.

26

126) Furanyl Nucleosides: Synthesis and Kinetics of Their Formation

Chatgilialoglu, C.; Vrantza, D.; Gimisis, T.

Tetrahedron Lett. 2004, 45, 4515-4517.

127) Liquid-Phase Oxidation of Pentamethyldisilane with Oxygen

Timokhin V. I.; Zaborovskii A. B.; Ferreri C.; Chatgilialoglu C.

Russ. J. Gen. Chem. 2004, 74, 469–469.

128) Excess Electron Transfer in G-Quadruplex

De Champdoré, M.; De Napoli, L.; Montesarchio, D.; Piccialli, G.; Caminal C.;

Mulazzani, Q. G.; Navacchia, M. L.; Chatgilialoglu, C.

Chem. Commun. 2004, 1756–1757.

129) A Mechanistic Investigation of (Me3Si)3SiH Oxidation

Zaborovskiy A. B.; Lutsyk D. S.; Prystansky R. E.; Kopylets V. I.; Timokhin V. I.;

Chatgilialoglu C.

J. Organomet. Chem. 2004, 689, 2912–2919.

130) Thiyl Radicals-Catalyzed Isomerization of Oils: An Entry to the Trans Lipid

Library

Samadi, A.; Andreu, I.; Ferreri, C.; Dellonte, S.; Chatgilialoglu, C.

J. Am. Oil Chem. Soc. 2004, 81, 753–758.

131) Synthesis and Biological Evaluation of Novel 1'- Branched and Spironucleoside

Analogues

Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.; Roberti, M.; Balzarini, J.; De Clercq, E.

Nucleosides, Nucleotides & Nucleic Acids 2004, 23, 1565–1581.

132) Liquid–Phase Oxidation of tert-Buthyldimethylsilane

Lutsik-Maksim, D. S.; Timokhin V. I.; Zaborovskii, A. B.; Prystanskii, R. E.;

Turovskii, A.A.; Chatgilialoglu C.

Russ. J. Gen. Chem. 2004, 74, 1508–1512.

27

133) The Photochemistry of 8-Bromo-2’-deoxyadenosine. A Direct Entry to Cyclopurine

Lesions

Jimenez, L. B.; Encinas, S.; Miranda, M. A.; Navacchia, M. L.; Chatgilialoglu, C.

Photochem. Photobiol. Sci. 2004, 3, 1042–1046.

134) A Biomimetic Model of Tandem Radical Damage Involving Sulfur-Containing

Protein and Unsaturated Lipids

Ferreri, C.; Manco, I.; Faraone-Mennella, M. R.; Torreggiani, A.; Tamba, M.;

Chatgilialoglu, C.

ChemBioChem 2004, 5, 1710–1712.

Year 2003

120) Model Studies of DNA C5' Radicals. Selective Generation and Reactivity of 2'-

Deoxyadenosin-5'-yl Radical

Chatgilialoglu, C.; Guerra, M.; Mulazzani, Q. G.

J. Am. Chem. Soc. 2003, 125, 3839–3848.

121) Rate Constants for the β-Elimination of Tosyl Radical from a Variety of Substituted

Carbon-Centered Radicals

Timokhin, V. I.; Gastaldi, S.; Bertrand, M. P.; Chatgilialoglu, C.

J. Org. Chem. 2003, 68, 3532–3537.

122) Kinetics of Liquid–Phase Oxidation of Poly(phenylsilane)

Zaborovskiy A. B.; Timokhin V. I.; Chatgilialoglu C.

Polym. Sci. Ser. A 2003, 45, 612–616.

Year 2002

115) Kinetic and Product Studies of the Reaction of Triorganosilanes with

Dimethyldioxirane

Grabovskii, S. A.; Kabal’nova, N. N.; Shereshovets, V. V.; Chatgilialoglu, C.


28

116) 5-Endo-trig Radical Cyclizations: Disfavored or Favored Processes?

Chatgilialoglu, C.; Ferreri, C.; Guerra, M.; Timokhin, V.; Froudakis, G.; Gimisis, T.

J. Am. Chem. Soc. 2002, 124, 10765–10772.

117) The Kinetics of Thiyl Radical Induced Reactions of Monounsaturated Fatty Acid

Esters

Chatgilialoglu, C.; Altieri, A.; Fischer, H.

J. Am. Chem. Soc. 2002, 124, 12816–12823.

118) Arachidonate Geometrical Isomers Generated by Thiyl Radicals: The Relationship

with Trans Lipids detected in Biological Samples

Ferreri, C.; Faraone Mennella, M. R.; Formisano, C.; Landi, L.; Chatgilialoglu, C.


119) Geometrical Isomerism of Monounsaturated Fatty Acids: Thiyl Radical Catalysis

and Influence of Antioxidant Vitamins

Chatgilialoglu, C.; Zambonin, L.; Altieri, A.; Ferreri, C.; Mulazzani, Q. G.; Landi,

L.;


Year 2001

112) Cis–Trans Isomerization of Polyunsaturated Fatty Acid Residues in Phospholipids

Catalyzed by Thiyl Radicals

Ferreri, C.; Costantino, C.; Perrotta, L.; Landi, L.; Mulazzani, Q. G.; Chatgilialoglu,

C.

J. Am. Chem. Soc. 2001, 123, 4459–4468.

113) Free Radicals Associated with DNA Damage

Chatgilialoglu, C.; O’Neill, P.

Exp. Gerontol. 2001, 36, 1459–1471.

29

114) Reactivity of Tris(trimethylsilyl)silane Towards Diarylaminyl Radicals

Varlamov, V. T.; Denisov, E. T.; Chatgilialoglu, C.

J. Org. Chem. 2001, 66, 6317–6322.

Year 2000

106) Rate Constants for the Reaction of Cumylperoxyl Radicals with Group 14 Hydrides

Chatgilialoglu, C.; Timokhin, V. I.; Zaborovskiy, A. B.; Lutsyk, D. S.; Prystansky,

R. E.

J. Chem. Soc. Perkin Trans 2 2000, 577–581.

107) Radiation Chemical Studies of 8-Bromoguanosine in Aqueous Solution

Ioele, M.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G.

J. Am. Chem. Soc. 2000, 122, 1900–1907.

108) Fate of the 2’-Deoxyadenosin-5’-yl Radical under Anaerobic Conditions

Flyunt, R.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G.

J. Am. Chem. Soc. 2000, 122, 4225–4226.

109) cis–trans Isomerization of Monounsaturated Fatty Acid Residues in Phospholipids

by Thiyl Radicals

Chatgilialoglu, C.; Ferreri, C.; Ballestri, M.; Mulazzani, Q. G.; Landi, L.

J. Am. Chem. Soc. 2000, 122, 4593–4601.

110) Model of DNA C1’ Radicals. Structural, Spectral and Chemical Properties of the

Thyminylmethyl Radical and the 2’-Deoxyuridin-1’-yl Radical

Chatgilialoglu, C.; Ferreri, C.; Bazzanini, R.; Guerra, M.; Choi, S-Y.; Emanuel, C.

J.; Horner, J. H.; Newcomb,.M.

J. Am. Chem. Soc. 2000, 122, 9525–9533.

111) Radical-Based Reduction of Phosphine Sulfides and Phosphine Selenides by

(Me3Si)3SiH

Romeo, R.; Wozniak, L. A.; Chatgilialoglu, C.

30


Year 1999

94) The PdCl2/R3SiH System for the Silylation of Nucleosides

Ferreri, C.; Costantino, C.; Romeo, R.; Chatgilialoglu, C.


95) Rate Constants for the Reaction of Cumylperoxyl Radicals with Bu3SnH and

(TMS)3SiH

Chatgilialoglu, C.; Timokhin, V. I.; Zaborovskiy, A. B.; Lutsyk, D. S.; Prystansky,

R. E.

Chem. Commun. 1999, 405–406.

96) The Thiyl Radical-Mediated Isomerization of cis-Monounsaturated Fatty Acid

Residues in Phospholipids: A Novel Path of Membrane Damage?

Ferreri, C.; Costantino, C.; Landi, L.; Mulazzani, Q. G.; Chatgilialoglu, C.

Chem. Commun. 1999, 407–408.

97) Anionically Induced Formation of Anomeric Spironucleosides from 1’-C-Cyano-2’-

deoxyuridine

Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.


98) Kinetics of 2’-Deoxyuridin-1’-yl Radical Reactions

Emanuel, C. J.; Newcomb, M.; Ferreri, C.; Chatgilialoglu, C.

J. Am. Chem. Soc. 1999, 121, 2927–2928.

99) Hydrogen Donor Abilities of the Germanium Hydrides

Chatgilialoglu, C.; Ballestri, M.; Escudié, J.; Pailhous, I.


100) Mechanistic and Synthetic Aspects of the C-1’ Radicals in Modified Nucleosides

31

Chatgilialoglu, C.

Nucleosides Nucleotides 1999, 18, 547–553.

101) Ex-novo and Revisum Procedures for the Preparation of C-1’ Branched Nucleosides

Chatgilialoglu, C.; Costantino, C.; Ferreri, C.; Gimisis, T.; Romagnoli, A.; Romeo,

R.

Nucleosides Nucleotides 1999, 18, 637–639.

102) C-1’ Radicals in Nucleosides

Chatgilialoglu, C.

Il Farmaco 1999, 54, 321–325.

103) Chemistry of Acyl Radicals

Chatgilialoglu, C.; Crich, D.; Komatsu, M.; Ryu, I.

Chem. Rev. 1999, 99, 1991–2069.

104) Hydrogen Donor Abilities of the Group 14 Hydrides

Chatgilialoglu, C.; Newcomb, M.

Adv. Organomet. Chem. 1999, 44, 67–112.

105) C-1’ Radical-Based Approaches for the Synthesis of Anomeric Spironucleosides

Chatgilialoglu, C.; Gimisis, T. Spada, G. P.

Chem. Eur. J. 1999, 5, 2866–2876.

Year 1998

85) Generation of C-1' Radicals Through a β-(Acyloxy)alkyl Rearrangement in

Modified Purines and Pyrimidine Nucleosides

Gimisis, T.; Ialongo, G; Chatgilialoglu, C.

Tetrahedron 1998, 54, 573–592.

86) One-Carbon Ring Expansion in Cyclopentanones as a Free-Radical Clock

Chatgilialoglu, C.; Timokhin, V. I.; Ballestri, M.

32

J. Org. Chem. 1998, 63, 1327–1329.

87) Homolytic reactivity of Group 14 Organometallic Hydrides Towards Nitroxides

Lucarini, M.; Marchesi, E.; Pedulli, G.F.; Chatgilialoglu, C.

J. Org. Chem. 1998, 63, 1687–1693.

88) The Versatile Behavior of the PdCl2/Et3SiH System. Conversion of Alcohols to the

Corresponding Halides and Alkanes

Ferreri, C.; Costantino, C.; Chatgilialoglu, C.; Boukherroub, R.; Manuel. G.

J. Organomet. Chem. 1998, 554, 135–137.

89) Autoxidation of Poly(hydrosilane)s

Chatgilialoglu, C.; Guerrini, A.; Lucarini, M.; Pedulli, G. F.; Carrozza, P.; DaRoit,

G.; Borzatta, V.; Lucchini, V.


90) Spectra and Structure of the 2'-Deoxyuridin-1'-yl Radical

Chatgilialoglu, C.; Gimisis, T.; Guerra, M.; Ferreri, C.; Emanuel, C. J.; Horner, J.

H.; Newcomb, M.; Lucarini, M.; Pedulli, G.F.


91) Fate of the C-1’ Peroxyl Radical in the 2’-Deoxyuridine System

Chatgilialoglu, C.; Gimisis, T.

Chem. Commun. 1998, 1249–1250.

92) Reactions of Oxide Radical Ion (•O–) with Pyrimidine and Purine Derivatives

Ioele, M.; Chatgilialoglu, C.; Mulazzani, G.

J. Phys. Chem. A 1998, 102, 6259–6265.

93) Catalytic Ferrier Rearrangement of Unsaturated Nucleosides

Linker, T.; Sommermann, T.; Gimisis, T.; Chatgilialoglu, C.


33

Year 1997

81) 5-exo-trig versus 6-endo-trig Cyclization of Alk-5-enoyl Radicals. The Role of One-

Carbon Ring Expansion

Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.; Venturini, A.; Zavitsas, A. A.

Chem. Eur. J. 1997, 3, 376–387.

82) A New Class of Anomeric Spironucleosides

Gimisis, T.; Castellari, C.; Chatgilialoglu, C.

Chem. Commun. 1997, 2089–2090.

83) Addition of Tris(trimethylsilyl)germyl Radicals to Unsaturated Compounds. An

EPR and Product Study

Bernardoni, S.; Lucarini, M.; Pedulli, G. F.; Valgimigli, L.; Gevorgyan, V.;

Chatgilialoglu, C.

J. Org. Chem. 1997, 62, 8009–8014.

84) Free Radical Chemistry Associated with H(RSiH)nH

Chatgilialoglu, C.; Ferreri, C.; Vecchi, D.; Lucarini, M.; Pedulli, G. F.

J. Organomet. Chem. 1997, 546, 475–481.

Year 1996

75) PdCl2-Catalyzed Reduction of Organic Halides by Triethylsilane

Boukherroub, R.; Chatgilialoglu, C.; Manuel. G.


76) 1,5-Radical Translocation Protocol for the Generation of C-1’ Radicals in

Nucleosides. Synthesis of Spiro Nucleosides through a Rare 5-endo-trig Cyclization

Gimisis, T.; Chatgilialoglu, C.

J. Org. Chem. 1996, 61, 1908–1909.

77) Free Radical Carbonylation of 1,4-cis-Polybutadiene

34

Chatgilialoglu, C.; Ferreri, C.; Sommazzi, A.

J. Am. Chem. Soc. 1996, 118, 7223–7224.

78) Synthesis of 2-Functionalized Allyl Tris(trimethylsilyl)silanes

Chatgilialoglu, C.; Ballestri, M.; Vecchi, D.; Curran, D. P.


79) 2-Functionalized Allyl Tris(trimethylsilyl)silanes as Radical-Based Allylating

Agents

Chatgilialoglu, C.; Ferreri, C.; Ballestri, M.; Curran, D. P.


80) Tris(trimethylsilyl)silane as Mediator in the Radical-Based Allylation Reactions of

Allyl and 2-Functionalized Allyl Phenyl Sulfones

Chatgilialoglu, C.; Alberti, A.; Ballestri, M.; Macciantelli, D.; Curran, D. P.


Year 1995

66) Rate Constant for the Reaction of Acyl Radicals with Bu3SnH and (TMS)3SiH

Chatgilialoglu, C.; Lucarini, M.


67) 5,10-Dihydro-Silanthrene as a Reagent for the Barton-McCombie Reaction

Gimisis, T.; Ballestri, M.; Ferreri, C.; Chatgilialoglu, C.; Boukherroub, R.; Manuel,

G.


68) Rate Constants and Arrhenius Parameters for the Reaction of Acyl Radicals with

Bu3SnH and (Me3Si)3SiH

Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.; Pedrielli, P.; Pedulli, G. F.


35

69) (Z)–(E) Interconversion of Olefins by the Addition–Elimination Sequence of the

(TMS)3Si• Radical

Chatgilialoglu, C.; Ballestri, M.; Ferreri, C.; Vecchi, D.

J. Org. Chem. 1995, 60, 3826–3831.

70) Structural and Chemical Properties of Silyl Radicals

Chatgilialoglu, C.

Chem. Rev. 1995, 95, 1229–1251.

71) Radical Transformations of Nucleosides with (Me3Si)3SiH. Generation of a C-1’

Radical through 1,2-Migration of an Acyloxy Group

Gimisis, T.; Ialongo, G.; Zamboni, M.; Chatgilialoglu, C.


72) A Facile Entry to Secondary Cyclopropylcarbinols: Further Developments in the

Stereospecific Synthesis of (E)-Homoallylic Bromides

Ferreri, C.; Ambrosone, M.; Chatgilialoglu, C.

Synth. Commun. 1995, 25, 3351–3356.

73) Tris(trimethylsilyl)germane as a Radical-Based Reducing Agent

Chatgilialoglu, C.; Ballestri, M.


74) Energies of Activation. The Paradigm of Hydrogen Abstractions by Radicals

Zavitsas, A. A.; Chatgilialoglu, C.

J. Am. Chem. Soc. 1995, 117, 10645–10654.

Year 1994

65) Sulfur-Chlorine Bond Dissociation Enthalpies in Methane- and Benzene-sulfonyl

Chlorides

Chatgilialoglu, C.; Griller, D.; Kanabus-Kaminska, J. M.; Lossing, F. P.

J. Chem. Soc., Perkin Trans. 2 1994, 357–360.

36

Year 1993

61) A Comment on the Use of Triethylsilane as a Radical-Based Reducing Agent

Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.

J. Org. Chem. 1993, 58, 249–251.

62) Organosilanes as Radical-Based Reducing Agents with Low Hydrogen Donating

Abilities

Ballestri, M.; Chatgilialoglu, C.; Guerra, M.; Guerrini, A.; Lucarini, M.; Seconi, G.


63) An Unexpected Stereochemical Control of Alkene Formation by the Choice of

Radical Initiator. The Reversible Addition of (Me3Si)3Si• Radicals to Alkenes

Ferreri, C.; Ballestri, M.; Chatgilialoglu, C.


64) Progress of the Barton-McCombie Methodology: From Tin Hydrides to Silanes

Chatgilialoglu, C; Ferreri, C.

Res. Chem. Intermed. 1993, 19, 755–775.

Year 1992

52) Reactions of Tris(trimethylsilyl)silyl Radicals with Nitroalkanes. EPR, Kinetic, and

Product Studies

Ballestri, M.; Chatgilialoglu, C.; Lucarini, M.; Pedulli, G. F.

J. Org. Chem. 1992, 57, 948–952.

53) The Reaction of Tris(trimethylsilyl)silane with Acid Chlorides

Ballestri, M.; Chatgilialoglu, C.; Cardi, N.; Sommazzi, A.


54) Autoxidation of Tris(trimethylsilyl)silane

37

Chatgilialoglu, C.; Guarini, A.; Guerrini, A.; Seconi, G.

J. Org. Chem. 1992, 57, 2207–2208.

55) A Study on the Reducing Abilities of Tris(alkylthio)silanes

Chatgilialoglu, C.; Guerra, M.; Guerrini, A.; Seconi, G.; Clark, K. B.; Griller, D.;

Kanabus-Kaminska, J. M.; Martinho-Simoes, J. A.

J. Org. Chem. 1992, 57, 2427–2433.

56) Organosilanes as Radical-Based Reducing Agents in Synthesis

Chatgilialoglu, C.

Acc. Chem. Res. 1992, 25, 188–194.

57) Homolytic Substitution Reaction at a Silicon Atom

Kulicke, K. J.; Chatgilialoglu, C.; Kopping, B.; Giese, B.

Helv. Chim. Acta 1992, 75, 935–939.

58) The Me3Si Substituent Effect on the Reactivity of Silanes. Structural Correlations

Between Silyl Radicals and Their Parent Silanes.

Chatgilialoglu, C.; Guerrini, A.; Lucarini, M.

J. Org. Chem. 1992, 57, 3405–3409.

59) (Me3Si)3SiH: An Efficient Hydrosilylating Agent of Alkenes and Alkynes

Kopping, B.; Chatgilialoglu, C.; Zehnder, M.; Giese, B.

J. Org. Chem. 1992, 57, 3994–4000.

60) Electron Impact Studies of Alkanesulfonyl Chorides. An Investigation of the Sulfur

Dioxide Radical Cation

Chatgilialoglu, C.; Guerra, M.; Hamdan, M.; Traldi, P.;

Int. J. Mass Spectrom. Ion Processes 1992, 116, 115–125.

Year 1991

48) Tris(trimethylsilyl)silane as a Radical-Based Reducing Agent in Synthesis

38

Ballestri, M.; Chatgilialoglu, C.; Clark, K.B.; Griller, D.; Giese, B.; Kopping, B.

J. Org. Chem. 1991, 56, 678–683.

49) An Approach to the Electronic Properties of Sulfonyl and Sulfinyl Compounds by

Means of Sulfur-33 and Oxygen-17 NMR

Barbarella, G.; Bongini, A.; Chatgilialoglu, C.; Zambianchi, M.

Phosphorus, Sulfur, and Silicon 1991, 58, 491–494.

50) (Me3Si)3SiSH: A New Radical-Based Reducing Agent

Ballestri, M.; Chatgilialoglu, C.; Seconi, G.

J. Organomet. Chem. 1991, 408, C1–C4.

51) Rate Constants and Arrherius Parameters for the Reaction of Some Carbon-Centered

Radicals with Tris(trimethylsilyl)silane

Chatgilialoglu, C.; Dickhaut , J.; Giese, B.

J. Org. Chem. 1991, 56, 6399–6403.

Year 1990

43) Tris(alkylthio)silanes as New Reducing Agents via Radicals

Chatgilialoglu, C.; Guerrini, A.; Seconi, G.

Synlett 1990, 219–220.

44) MSXα Study of Absorption Spectra of Free Radicals. Characterization of Rydberg

and Valence Transitions in Alkyl Derivatives of Group14 Centered Radicals

Chatgilialoglu, C.; Guerra, M.

J. Am. Chem. Soc. 1990, 112, 2854–2859.

45) Addition of Tris(trimethylsilyl)silyl Radicals to the Carbonyl Group

Alberti, A.; Chatgilialoglu, C.

Tetrahedron 1990, 46, 3963–3972.

39

46) 33S and 17O NMR of Compounds Containing the SO2 Moiety. A Generalization of

the "Chlorine Effect"

Barbarella, G.; Chatgilialoglu, C.; Tugnoli, V.

J. Magn. Reson. 1990, 88, 277–283.

47) Alkyl Isocyanides as Precursors for the Formation of Carbon-Carbon Bonds

C. Chatgilialoglu, B. Giese and B. Kopping


Year 1989

38) Tris(trimethylsilyl)silane as Mediator in Organic Synthesis via Radicals

Giese, B.; Kopping, B.; Chatgilialoglu, C.


39) Rate Constants for the Reaction of Tris(trimethylsilyl)silyl Radicals with Organic

Halides

Chatgilialoglu, C.; Griller, D.; Lesage, M.

J. Org. Chem. 1989, 54, 2492–2494.

40) Amino- and Alkoxysulfonyl Radicals

Chatgilialoglu, C.; Griller, D.; Rossini, S.

J. Org. Chem. 1989, 54, 2734–2737.

41) Sulfonylium Ions in the Gas Phase

Chatgilialoglu, C.; Guerra, M.; Pelli, B.; Traldi, P.

Org. Mass Spectrom. 1989, 24, 455–460.

42) Tris(trimethylsilyl)silane: A Catalyst for Radical Mediated Reduction Reactions

Lesage, M.; Chatgilialoglu, C.; Griller, D.;


Year 1988

40

36) The Substituent Effect on the Reactivity of Silanes Towards tert-Butoxyl Radicals

Chatgilialoglu, C.; Rossini, S.

Bull. Chim. Soc. Fr. 1988, 298–300.

37) Tris(trimethylsilyl)silane. A New Reducing Agent


J. Org. Chem. 1988, 53, 3641–3642.

Year 1987

32) Absolute Rate Constants for the Reaction of Triethylsilyl Radicals with Ring-

Substituted Benzyl Chlorides

Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C.

J. Org. Chem. 1987, 52, 938–940.

33) Experimental and Theoretical Approaches to the Optical Absorption Spectra of

Sulfonyl Radicals

Chatgilialoglu, C.; Griller, D.; Guerra, M.

J. Phys. Chem. 1987, 91, 3747–3750.

34) Reduction of Silicon–Hydrogen Bond Strengths

Kanabus-Kaminska, J. M.; Hawari, J. A.; Griller, D.; Chatgilialoglu, C.

J. Am. Chem. Soc. 1987, 109, 5267–5268.

35) Sulfur-33 NMR of Cyclic Sulfides, Sulfoxides and Sulfones

Barbarella, G.; Bongini, A.; Chatgilialoglu, C.; Rossini, S.; Tugnoli, V.

J. Org. Chem. 1987, 52, 3857–3860.

Year 1986

27) Absolute Rate Constants for the Reactions of α-Toluenesulfonyl Chloride with

Carbon-Centered Radicals

41

Chatgilialoglu, C.

J. Org. Chem. 1986, 51, 2871–2873.

28) An Investigation of Structure and Conformation of Thiophene-2-sulphonyl Radicals

Alberti, A.; Chatgilialoglu, C.; Guerra, M.


29) On the Addition of Silyl Radicals to Unsaturated Carbonyl Compounds:

Regioselectivity of the Attack and 1,3 Carbon to Oxygen Silicon Migration

Alberti, A.; Chatgilialoglu, C.; Pedulli, G. F.; Zanirato, P.

J. Am. Chem. Soc. 1986, 108, 4993–4998.

30) Arrhenius Parameters for the Reaction of tert-Butoxyl Radicals with Triethylsilane

Chatgilialoglu, C.

Gazz. Chim. Ital. 1986, 116, 511–513.

31) 33S and 17O NMR of Compounds Containing the SO2 Moiety. The Chlorine Effect

Barbarella, G.; Chatgilialoglu, C.; Rossini, S.; Tugnoli, V.

J. Magn. Reson. 1986, 70, 204–212.

Year 1985

26) Structural and Optical Absorption Spectra of Some Sulfuranyl Radicals in Solution

Chatgilialoglu, C.; Castelhano, A. L.; Griller, D.

J. Org. Chem. 1985, 50, 2516–2518.

Year 1984

24) Conformational Studies by Dynamic Nuclear Magnetic Resonance. Part 26.

Interconversion Barriers between syn- and anti- Conformers of Isomeric

Thiophenecarbaldehydes

Lunazzi, L.; Placucci, G.; Chatgilialoglu, C.; Macciantelli, D.


42

25) Absolute Rate Constants for Hydrogen Abstraction from Aldehydes and

Conformational Studies of the Corresponding Aromatic Acyl Radicals

Chatgilialoglu, C.; Lunazzi, L.; Macciantelli, D.; Placucci, G.

J. Am. Chem. Soc. 1984, 106, 5252–5256.

Year 1983

18) Intramolecular and Intermolecular Reactions of Alkenylsilyl Radicals

Chatgilialoglu, C.; Woynar, H.; Ingold, K. U.; Davies, A. G.


19) Absolute Rate Constants for the Addition of Triethylsilyl Radicals to Various

Unsaturated Compounds


J. Am. Chem. Soc. 1983, 105, 3292–3296.

20) A Homoallyl Radical Rearrangement. Kinetics of the Isomerization of the 2,2-

Dimethyl-3-buten-1-yl Radical to the 1,1-Dimethyl-3-buten-1-yl Radical

Chatgilialoglu, C.; Ingold, K. U.; Tse-Sheepy, I.; Warkentin, J.

Can. J. Chem. 1983, 61, 1077–1081.

21) Formation, Decay, and Spectral Characterization of Some Alkyl- and Aryl-

Substituted Carbon-, Silicon-, Germanium-, and Tin-Centered Radicals

Chatgilialoglu, C.; Ingold, K. U.; Lusztyk, J.; Nazran, A. S.; Scaiano, J. C.


22) Kinetic Studies on the Formation and Decay of Some Sulfonyl Radicals

Chatgilialoglu, C.; Lunazzi, L.; Ingold, K. U.

J. Org. Chem. 1983, 48, 3588–3589.

23) Reaction of Bis(trifluoromethyl)aminoxyl with Cyclopropane

Anpo, M.; Chatgilialoglu, C.; Ingold, K. U.

43

J. Org. Chem. 1983, 48, 4104–4106.

Year 1982

13) Absolute Rate Constants for the Reactions of tert-Butoxyl Radicals and Some

Ketone Triplets with Silanes

Chatgilialoglu, C.; Scaiano, J. C.; Ingold, K. U.


14) Absolute Rate Constants for the Addition of Triethylsilyl Radicals to the Carbonyl

Group


J. Am. Chem. Soc. 1982, 104, 5119–5123.

15) Absolute Rate Constants for the Reaction of Triethylsilyl Radicals with Organic

Halides


J. Am. Chem. Soc. 1982, 104, 5123–5127.

16) Attempted Spin Trapping of tert-Butylperoxyl Radicals by Trifluoronitrosomethane

Chatgilialoglu, C.; Howard, J. A.; Ingold, K. U.

J. Org. Chem. 1982, 47, 4361–4362.

17) Hindered Rotation of the CF3 Group in tert-Butoxy Trifluoromethyl Nitroxide

Chatgilialoglu, C.; Ingold, K. U.

J. Phys. Chem. 1982, 86, 4372–4375.

Year 1981

8) Absolute Rate Constants for Some Reactions Involving Triethylsilyl Radicals in

Solution

Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C.; Woynar, H.

J. Am. Chem. Soc. 1981, 103, 3231–3232.

44

9) Configuration and Conformation of Alkoxyalkyl and Hydroxyalkyl Trifluoromethyl

Nitroxides. Anomeric Effects and Nitroxide Conformations


Can. J. Chem. 1981, 59, 1745–1752.

10) "Spontaneous" Formation of Radicals from Nitroso Compounds. Inadvertent

Photolysis vs. Molecule Assisted Homolysis


J. Am. Chem. Soc. 1981, 103, 4833–4837.

11) Infrared and Raman Spectra of N,N-Bis(trifluoromethyl)hydroxylamine and

Bis(trifluoromethyl) Nitroxide

Compton, D. A. C.; Chatgilialoglu, C.; Mantsch, H. H.; Ingold, K. U.

J. Phys. Chem. 1981, 85, 3093–3100.

12) Rate Constants and Arrhenius Parameters for the Reactions of Primary, Secondary,

and Tertiary Alkyl Radicals with Tri-n-butyltin Hydride


J. Am. Chem. Soc. 1981, 103, 7739–7742.

Year 1980

4) Electron Spin Resonance Studies of Radicals formed during the Thermolysis and

Photolysis of Sulphoxides and Thiosulphonates

Chatgilialoglu, C.; Gilbert, B. C.; Gill, B.; Sexton, M. D.


5) E.s.r. Studies of the Generation and Structure of Aminosulphonyl (Sulphamoyl)

Radicals, R2NSO2•

Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.; Symons, M. C. R.

J. Chem. Res. 1980, (S) 185, (M) 2610–2623.

45

6) Investigations of Structure and Conformation. Part 14. INDO and Electron Spin

Resonance Studies of Aliphatic Sulphonyl Radicals

Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.


7) Bis(trifluoromethyl)aminyl and Bis(trifluoromethyl) Nitroxide

Chatgilialoglu, C.; Malatesta, V.; Ingold, K. U.

J. Phys. Chem. 1980, 84, 3597–3599.

Year 1979

2) Investigations of structure and conformation. Part 12. The structure of aromatic

sulphonyl radicals: an e.s.r. and INDO molecular orbital study

Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.


3) Electron spin resonance studies. Part 57. Alkane- and arene-sulphinate esters: an

investigation of their photochemical decomposition and reactions with the t-butoxyl

radical

Chatgilialoglu, C.; Gilbert, B. C.; Kirk, C. M.; Norman, R. O. C.


Year 1977

1) Addition of some 1,3-diaryltriazenes to tetracyanoethylene

Camaggi, C. M.; Leardini, R.; Chatgilialoglu, C.

J. Org. Chem. 1977, 42, 2611–2614.

46

Publications in Books

1) Quantum Mechanical Tunneling in Free Radical Reactions.

Malatesta, V.; Ingold, K. U.; Chatgilialoglu, C.

Fast Reactions in Energetic Systems; Capellos, C.; Walker, R. F., Eds; D. Reidel:

Dordrecht, 1981; pp. 541–551.

2) Studies on Some Trifluoromethyl Nitroxide Radicals by EPR Spectroscopy.

Chatgilialoglu, C.; Ingold, K. U.; Malatesta, V.

Fast Reactions in Energetic Systems; Capellos, C.; Walker, R. F., Eds; D. Reidel:

Dordrecht, 1981; pp. 553–559.

3) Radical Reaction: Part 1.


Organic Reaction Mechanisms; Knipe, A. C.; Watts, W. E., Eds; Wiley: Chichester,

1984; pp. 73–108.




1985; pp. 83–127.




1986; pp. 87–137.

6) Formation, Decay, and Spectral Characterization of Some Sulfonyl Radicals.

Chatgilialoglu, C.

Advances in Chemical Reaction Dynamics; Rentzepis, P. M.; Capellos, C., Eds; D.

Reidel: Dordrecht, 1986; pp. 571–579.


47



1987; pp. 85–128.

8) Sulfinyl Radicals.

Chatgilialoglu, C.

The Chemistry of Sulfones and Sulfoxides; Patai, S.; Rappoport, Z.; Stirling, C. J.

M., Eds; Wiley: London, 1988; pp. 1081–1087.

9) Sulfonyl Radicals.

Chatgilialoglu, C.

The Chemistry of Sulfones and Sulfoxides; Patai, S.; Rappoport, Z.; Stirling, C. J.

M., Eds; Wiley: London, 1988; pp. 1089–1113.

10) Recent Advances in the Chemistry of Silyl radicals.

Chatgilialoglu, C.

Paramagnetic Organometallic Species in Activation/Selectivity, Catalysis; Chanon,

M.; Julliard, M.; Poite, J. C., Eds; Kluwer: Dordrecht, 1989; pp. 119–129.

11) Silanes as New Reducing Agents in Organic Synthesis.

Chatgilialoglu, C.

Free Radicals in Synthesis and Biology; Minisci, F., Ed.; Kluwer: Dordrecht, 1989;

pp. 115–123.

12) Electronic Absorption Spectra of Free Radicals.

Chatgilialoglu, C.

Handbook of Organic Photochemistry; Scaiano, J. C., Ed.; CRC Press: Boca Raton,

1989; Vol. II; pp. 3–11.

13) Free Radical Chemistry of Sulfenic Acids and Their Derivatives.

Chatgilialoglu, C.

The Chemistry of Sulfenic Acids and Their Derivatives; Patai, S., Ed.; Wiley:

London, 1990; pp. 549–569.

48

14) Alkanethiylperoxyl Radicals.

Chatgilialoglu, C.; Guerra, M.

Sulfur–Centered Reactive Intermediates in Chemistry and Biology; Chatgilialoglu,

C.; Asmus, K.-D., Eds; Plenum Press: New York, 1990; pp. 31–36.

15) Recent Advances in the Chemistry of Compounds Containing S-Si Moiety.

Ballestri, M.; Chatgilialoglu, C.; Dembech, P.; Guerrini, A.; Seconi, G.

Sulfur–Centered Reactive Intermediates in Chemistry and Biology; Chatgilialoglu,

C.; Asmus, K.-D., Eds; Plenum Press: New York, 1990; pp. 319–325.

16) Proprietà Strutturali e Chimiche di Alcuni Radicali Centrati allo Zolfo.

Chatgilialoglu, C.

V Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni; Serie

Simposi (ENEA): Roma, 1991; pp. 247–257.

17) Thiyl Radicals.

Chatgilialoglu, C; Guerra, M.

Supplement S: The Chemistry of Sulfur-containing Functional Groups; Patai, S.;

Rappoport, Z., Ed.; Wiley: London, 1993; pp. 363–394.

18) Free Radical Addition Involving C-C Triple Bonds.


Supplement C: The Chemistry of Triple-bonded Functional Groups; Patai, S., Ed.;

Wiley: London, 1994; pp. 917–944.

19) The Advancement of Radical-Based Synthetic Strategies: From Reagent Design to

Polymer Modification

Chatgilialoglu, C.

Chemical Synthesis: Gnosis to Prognosis; Chatgilialoglu, C.; Snieckus, V., Eds;

Kluwer: Dordrecht, 1996; pp. 263–276.

49

20) Free Radical Chemistry Associated with C-1’ Position of Nucleosides and Nucleic

Acids.

Chatgilialoglu, C.; Gimisis, T.

Free Radicals in Biology and Enviroment; Minisci, F., Ed.; Kluwer: Dordrecht,

1997; pp. 281–292.

21) Tris(trimethylsilyl)silane in Organic Synthesis

Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.

The Chemistry of Organic Silicon Compounds, Vol 2; Rappoport, S.; Apeloig, Y.,

Eds.; Wiley: Chichester, 1998; pp. 1539–1579.

22) Sulfur-Centered Radicals in Organic Synthesis

Chatgilialoglu, C.; Bertrand, M. P.; Ferreri, C.

S-Centered Radicals; Alfassi, Z. B., Ed.; Wiley: Chichester, 1999; pp. 311–354.

23) Organic Synthesis by Radical Reactions

Chatgilialoglu, C.; Renaud, P.

General Aspects of Free Radical Chemistry; Alfassi, Z. B., Ed.; Wiley: Chichester,

1999; pp. 501–538.

24) Tin Silicon and Related Reducing Agents

Chatgilialoglu, C.

Radicals in Organic Synthesis, Vol 1; Renaud, P.; Sibi, M. P., Eds; Wiley-VCH:

Weinheim, 2001; pp. 28–49.

25) Silyl Radicals

Chatgilialoglu, C.; Schiesser, C. H.

The Chemistry of Organic Silicon Compounds, Vol 3; Rappoport, S.; Apeloig, Y.,

Eds.; Wiley: Chichester, 2001; pp. 341–390.

26) Fatty Acids and Phospholipids

Chatgilialoglu, C.; Ferreri, C.;

50

Cis-Trans Isomerization: From Biology to Supramolecular Chemistry; Dugave, C.,

Ed.; Wiley-VCH: Weinheim, 2006; pp. 95–12.

27) Membrane Lipidomics and the Geometry of Unsaturated Fatty Acids: From

Biomimetic Models to Biological Consequences


Lipidomics. Vol. 1: Methods and Protocols; Armstrong, D., Ed.; Humana Press:

New York, 2009; pp. 391–412.

28) Reactivity of nucleic acid sugar radicals

Chatgilialoglu, C.

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry; Greenberg, M. M.,

Ed.; Wiley: New Jersey 2009; Chapter 4; pp. 99–133.

29) Biomimetic chemistry: radical reactions in vesicle suspensions


Biomimetics, Lerning from Nature; Mukherjee, A., Ed.; IN-TECH: Vienna, 2010;

Ch. 6; pp. 117–135.

30) Silanes as Reducing Reagents in Radical Chemistry

Chatgilialoglu, C.; Timokhin, V. I.

Encyclopedia of Radical in Chemistry, Biology & Materials; Chatgilialoglu, C.;

Studer, A., Eds.; Wiley: Chichester, 2012; Vol. 2; Ch. 22; pp. 561–600.

31) Oxidatively Formed Sugar Radicals in Nucleic Acids

Gimisis, T.; Chatgilialoglu, C.



32) Lipid Isomerization




51

Publications in Magazines and Online Resources

1) (TMS)3SiH in organic synthesis: Part 1

Chatgilialoglu, C.

Organic Chemistry Highlights 2004 (article online posting date October 5, 2004).

http://www.organic-chemistry.org/Highlights/2004/05October.shtm

2) (TMS)3SiH in organic synthesis: Part 2

Chatgilialoglu, C.

Organic Chemistry Highlights 2004 (article online posting date November 5, 2004).

http://www.organic-chemistry.org/Highlights/2004/05November.shtm

3) Free radical pathway to geometrical trans lipids


Inform 2006, 17, 435–437.

4) 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Chatgilialoglu, C.; Navacchia M. L.; Perchyonok, T. V.

Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd.,

2006; DOI: 10.1002/047084289X.rd135.pub2 (article online posting date

September 15, 2006).

5) Tris(trimethylsilyl)silane

Chatgilialoglu, C.

Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd.,

2007; DOI: 10.1002/047084289X.rt420.pub2 (article online posting date March 15,

2007)

6) Fats of life… explaining the villainous properties of trans fats

Chatgilialoglu, C.

Optimum Nutrition 2007 (Issue 2), 40–43.

52

7) The lipidomic approach: Transfer chemical research to a spin-off initiative in health

care

Ferreri, C.; Chatgilialoglu C.; Ferreri, R.

Industry & Higher Education 2008, 22, 403–409.

53

Publications as Meeting Abstracts

1) Trans-Phospholipids in Membranes: Methods of Formation and Properties

Chatgilialoglu, C.; Ferreri, C.; Dellonte, S.; Altieri, A.; Sassatelli, F.; Zambonin, L.;

Landi, L.

Chem. Phys. Lipids 2002, 118, 44–45.

2) Trans-Lipids Formed by a Thiyl Radical Catalyzed Process and Their Relevance in

Skin Disorders

Ferreri, C.; Chatgilialoglu, C.; Dellonte, S.; Samadi, A.; Manco, I; Faraone-

Mennella, R.; Neri, I.; Maranini, A. R.

Chem. Phys. Lipids 2002, 118, 90–91.

3) All-trans PUFA Synthesis by the Thiyl Radical–Catalysed Methodology and Their

Effects on Rabbit Platelet Aggregation

Anagnostopoulos, D.; Chatgilialoglu C.; Ferreri C.; Samadi, A.; Siafaka–Kapadai,

A.

Chem. Phys. Lipids 2004, 130, 67–67.

4) Trans Fatty Acid and Atopic Eczema/Dermatitis Syndrome: The relationship with a

free radical cis-trans isomerization of membrane lipids trans LIPIDS in atopic

dermatitis.

Chini, L.; Angelini, F.; Chatgilialoglu, C.; Dellonte, S.; Moschese, V.; Corrente, S.;

Iannini, R.; Chianca, M.; Rossi, P.; Ferreri, C.

Clin. Immunol. 2005, 115, S54–S55.

5) Endogenous formation of trans fatty acids in rats fed a trans-free diet

Zambonin, L.; Cabrini, L.; Prata, C.; Ferreri, C.; Chatgilialoglu, C.; Landi, L.

Chem. Phys. Lipids 2005, 136, 165–166.

6) Trans Lipids and Radical Stress


Chem. Phys. Lipids 2006, 143, 80–81.

54

7) Thiyl and sulphonyl radicals as catalytic agents for the cis-trans isomerization of

unsaturated fatty acid residues in liposomes

Tamba, M.; Mozziconacci, O.; Chatgilialoglu, C.; Ferreri, C

Free Radic. Res. 2007, 41, S57–S57.

8) Bleomycin increases trans lipid isomers in human testicular cancer cell membrane

Cort, A.; Ozben, T.; Kucuksayan, E.; Melchiorre, M.; Chatgilialoglu, C.; Ferreri, C.

FEBS J. 2011, 278, 201–201.

55

Editorial Activities for Scientific Journals

Guest Editor

1) Special issue of Helvitica Chimica Acta dedicated to the memory of Professor Hanns

Fischer

Chatgilialoglu, C.; Gescheidt, G. (Guest Editors)

Helvitica Chimica Acta 2006, volume 89, issue 10, pp. 2059 – 2589.

2) Special Issue of CHIMIA dedicated to “Free Radicals in Chemical Biology”

Chatgilialoglu, C. (Guest Editor)

Chimia 2008, volume 62, issue 9, pp. 703 – 749.

Member of Editorial Board

1) For the Journal of Glycomics and Lipidomics since 2011.

56

Books As Author

1) Organosilanes in Radical Chemistry

Author: Chryssostomos Chatgilialoglu

John Wiley & Sons Ltd, Chichester (UK), 2004.

Hardcover, 227 pages; ISBN: 0-471-49870-X

http://eu.wiley.com/WileyCDA/WileyTitle/productCd-047149870X.html

2) Membrana Cellulare e Lipidomica: La salute dalla medicina molecolare

Authors: Carla Ferreri and Chryssostomos Chatgilialoglu

Publisher: CNR Edizioni, Roma, October 2011.

http://www.edizioni.cnr.it/

57

As Editor

1) Sulfur-Centered Reactive Intermediates in Chemistry and Biology

Edited by C. Chatgilialoglu and K.-D. Asmus,

Plenum Press, New York, 1990.

2) Chemical Synthesis: Gnosis to Prognosis

Edited by C. Chatgilialoglu and V. Snieckus,

Kluwer Academic Publishers, Dordrecht, 1996.

3) Proceendings of of EUCHEM Conference on

Organic Free Radicals

Edited by Chryssostomos Chatgilialoglu

Publisher: Arcane editrice S.r.l., Roma, Italy,

June 2010.

ISBN 978-88-548-2214-2

4) Encyclopedia of Radicals in Chemistry, Biology

and Materials

(4 volumes, 73 Chapters and over 2300 pages)

Edited by Chryssostomos Chatgilialoglu and

Armido Studer

Publisher: Wiley, Chichester, UK, Ferbuary 2012.

ISBN: 978-0-470-97125-3

51

This volume covers the proceedings of the 12th EUCHEM Conference on Organic Free Radicalsin Bologna, June 28 – July 2, 2010. It covers the main fields of free radical chemistry from

organic synthesis to chemical biology and from polymers to materials. Numerous experts from allover the world have contributed with their lectures and papers. The variety of subjects demon-strates the attractiveness of free radical research, foreseeing a period of further growth for this field.

Chryssostomos Chatgilialoglu is Research Director at Consiglio Nazionale delle Ricerche, Bologna (Italy).His research interests lie in free radical reactions and in the last decade have been increasingly addressed

to applications in life sciences, such as biomimetic chemistry of radical stress and related biomarkers.

AR

AC

NE9 7 8 8 8 5 4 8 3 3 1 4 2

ISBN 978-88-548-3314-2

Organic Free Radicalsedited by C. Chatgilialoglu

Proceedings of EUCHEM Conference on

Organic Free Radicals

COVER: STUDIO BG

JUNE 28 – JULY 2, 2010, BOLOGNA, ITALY

edited by

Chryssostomos Chatgilialoglu

3314-2 copertina.qxp:A 170 mastro copertine 15/06/10 14:51 Pagina 1

58

Patents

1) Procedimento per la riduzione di alogenuri organici ai corrispodenti composti

dealogenati


IT Patent 48150A87 (1987).

2) Polymers containing repeating cycloketonic units, and method for obtaining them

Sommazzi, A.; Cardi, N.; Garbassi, F.; Chatgilialoglu, C.

US Patent 5,369,187 (1994).

3) Polyhydrosilanes as process stabilizers

Carrozza, P.; Borzatta, V.; Chatgilialoglu, C.

PCT Int. Appl. WO97/02322 (1997).

US Patent 6,005,036 (21.12.1999);

TW Patent 122742NI (23.03.2001); JP pending;

EP (BE, DE, FR, IT, NL) Patent 836635 (05.12.2001).

4) Polysilane stabilizer containing sterically hindered amine groups

Carrozza, P.; Borzatta, V.; Chatgilialoglu, C.; Da Roit, G.

PCT Int. Appl. WO00/64965 (2000).

US Patent 6,538,055 (25.03.2003);

JP pending; KR pending;

EP (BE, DE, ES, FR, GB, IT, NL) Patent 1185577 (21.05.2003).

5) Processo per l’isomerizzazione cis/trans di mono-, di-, e tri-gliceridi o loro miscele


IT Patent 13227121 (27.04.2005).

6) Metodo analitico per l’identificazione di componenti lipidiche contenenti doppi

legami con isomeria trans


IT Patent 1327120 (27.04.2005).

59

Conference and Visiting Activity

The conference and visiting activity of Dr. Chatgilialoglu is very intense and includes

invitations to scientific institutions and to international meetings, as well as several

visiting professorships spent in foreign Universities. This activity correlates with the high

reputation of the international scientific community that Dr. Chatgilialoglu has achieved,

and it can be a clear advantage for establishing firm relationship between Italy and

foreing countries. Lists of the commitments are reported in the following pages.

In the graph below, the over 114 invited lectures at institutions are distributed

geographically. It shows the worldwide recognition of Dr. Chatgilialoglu’s research.

Figure 2. Geographical Distribution of Invited Lectures at Institutions

Italy (17.5%)

Rest of Europe (42.1%)

USA (21.1%)

Rest of Americas (5.3)

Russia, Japan & Australia (14.0%)

60

Invited Lectures at Congresses and Meetings

1) Scuola GDRM. Fenomeni e tecniche emergenti delle risonanze magnetiche: epr e

nmr. (Roma, Italy, 19-24 May 1986).

Title: Misure di costanti di velocità di process radicali unimolecolari mediante

spettroscopia epr

2) Gordon Research Conference on Free Radical Reactions (Newport, USA, 24-28

August 1987).

Title: Novel silanes as radical reducing agents

3) NATO Advanced Research Workshop on “Paramagnetic organometallic species in

activation, selectivity, catalysis” (Saint-Maximin, France, 4 – 8 October 1987).

Title: Recent advances in the chemistry of silyl radicals

4) NATO Advanced Research Workshop on “Free radicals in synthesis and biology”

(Bardolino, Italy, 8-13 May 1988).

Title: Silanes as new reducing agents in organic synthesis

5) COFEM 88 (Frascati, Italy, 17-20 July 1988).

Title: Nuovi agenti riducenti per via radicalica

6) NATO Advanced Study Institute on “Sulfur-centered reactive ointermediates in

chemistry and biology (Maratea, Italy, 18-30 June 1989).

Title: Novel free radical chain reactions involving organosulfur compounds

7) V Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni

(Roma, Italy, 12-14 October 1989)

Title: Caratterizzazione e reazioni di radicali centrati allo zolfo

8) EUCHEM Conference on Organic Free Radicals (Arles, France, 21-26 August

1990)

Title: Organosilanes as radical-based reducing agents in synthesis

61

9) NATO ASI on "Chemical Synthesis: Gnosis to Prognosis" (Ravello, Italy, 8-19 May

1994).

Title: The advancement of radical-based synthetic strategies: From reagent design

to polymer modification

10) EUCHEM Conference on Organic Free Radicals (Champery, Switzerland, 21-26

August 1994)

Title: Acyl radicals as intermediates in the synthesis of new materials

11) NATO Advanced Research Workshop on “Free Radicals in Biology and

Environment” (Bardolino, Italy, 25 June 1996)

Title: Free radical chemistry associated with the C-1’ position of nucleosides

12) 3rd Winter Research Conferences on “Oxidative Effects of Radiations on

Biomolecules and Cells” (Les Arcs, France, 11 May 1997)

Title: Reaction of the O•- radical with nucleosides and related compounds

13) 30th Organosilicon Symposium, (London, Canada, 30-31 May 1997)

Title: Free radical chemistry associated with organosilanes: from reagent design to

polymer application

14) VIII Meeting: Strutture Eterocicliche nella Ricerca Farmaceutica, (Palermo, Italy,

17-20 May 1998).

Title: Free radical chemistry associated with the C1' position of nucleosides

15) XIII International Round Table: Nucleosides, Nucleotides, and Their Biological

Applications (Montpellier, France 6-10 September 1998).

Title: Mechanistic and synthetic aspects of the C-1’ radicals in modified nucleosides

16) Gordon Research Conference on Free Radical Reactions (Plymouth, USA, 11-16

July 1999).

Title: What’s new about thiols in free radical chemistry

62

17) 37th IUPAC Congress “Frontiers in Chemistry: Molecular Basis of the Life

Sciences” (Berlin, Germany, 14-19 August 1999)

Title: Structural Characteristics of C1’ Radical Nucleosides and Their Fate in the

Presence of Glutathione Under Anoxic or Aerobic Conditions

18) XXVI Convegno Naz. della Divisione di Chimica Organica (Giardini Naxos, Italy,

1-5 September 1999).

Title: Radicali in posizione anomerica di nucleosidi: aspetti sintetici e biologici

19) 2nd COST meeting on Radical Cascade Reactions (Glasgow, UK, 9 September,

1999).

Title: 5’,8-cyclopurines: Synthesis and mechanistic aspects

20) The 13th Brisbane Organic Chemistry Symposium (Brisbane, Australia, Nov. 26,

1999)


21) RACI NSW Organic Group. 20th Annual One Day Symposium (Wollongong,

Australia, Nov. 30, 1999)


22) 24th Annual Synthesis Symposium (Melbourne, Australia, 3 December 1999)


23) Adelaide Organic Chemistry Symposium (Adelaide, Australia 6 December 1999)


24) Gomberg 2000, the 8th International Symposium on Organic Free Radicals (Ann

Arbor, USA, June 25-29, 2000).

Title: Free Radicals in Nucleosides: Serendipity and Planning

63

25) XVIth International Symposium on Medicinal Chemistry (Bologna, Italy, 18-22

September, 2000).

Title: Synthesis of conformationally fixed nucleosides via radical cascade reactions

26) 3rd COST meeting on Radical Cascade Reactions (Fribourg, Switzerland, 20-22

October 2000)

Title: One-pot Synthesis of 5’,8-cyclopurines

27) Pacifichem 2000. Symposium No. 29: New Developments in Organic Radical

Chemistry (Honolulu, USA, 14-19 December 2000).


28) 22nd Miller Conference on Radiation Chemistry (Bowness on Windermere, UK, 7-

12 April 2001).

Title: The cis-trans isomerization of unsaturated fatty acid residues in lipids

catalyzed by thiyl radicals

29) 4th COST meeting on Radical Cascade Reactions (Madrid, Spain, 4-6 October 2001)

Title: Radical cascade reactions in aqueous solutions

30) International Conference on Reactive Intermediates and Reaction Mechanisms

(Ascona, Switzerland, 7-12 July 2002)

Title: The fate of C5’ radicals in purinef nucleosides

31) 6th Winter Research Conferences on “Oxidative Damage of DNA: Formation and

Biological Features” (Les Houches, Francia, 25-26 March 2003)

Title: Free radical chemistry in the carbohydrate moiety of nucleosides and

nucleostides

32) EYICS 2003 // SULFRAD Conference (Slubice, Poland, 7-11 May 2003)

Title: Free radical chemistry in the carbohydrate moiety of nucleosides

64

33) 9th International Symposium on Organic Free Radicals (Porto-Vecchio, France, 6-

11 June 2004)

Title: Paradoxical Generation of One-Electron Oxidized 2’-Deoxyguanosine Under

Reducing Conditions. Application to Excess Electron Transfer in

Oligodeoxyribonucleosides

34) COST P9 on Radiation Damage in Biomelecular Systems (Lyon, France, 24-27 June

2004)

Title: Interaction of Electrons with 8-Bromoadenine and 8-Bromoguanine

Derivatives

35) 1st Hellenic Symposium on Organic Synthesis (Athens, Greece, 4-6 November

2004)

Title: Trans lipids: The Free Radical Path

36) 1st Pacific Symposium on Radical Chemistry (Kanazawa, Japan, 15-16 November

2004)


37) Gordon Research Conference on Free Radical Reactions (Plymouth, USA, 3-8 July

2005)


38) 7th Winter Research Conferences on “Oxidatively Generated Damage to DNA:

Formation, Repair and Biological Features” (Les Houches, France, 19-22 March

2006)

Title: Radicals for sugar moieties of DNA and RNA models

39) EUCHEM Conference on Organic Free Radicals (Bergen, Norway, 9-13 July 2006)

Title: Radical reactions in water, on water and in vescicles

40) 6th CLUSTOXDNA meeting (Valencia, Spain, 29 October - 1 November 2006)

Title: Tautomerism in the guanyl radical

65

41) 4th SANIT: Il ruolo della ricerca nella sanità (Rome, Italy, 18-21 April 2007)

Title: Spin-off LIPINUTRAGEN

42) 2nd Greek Lipid Forum (Athens, Greece, 7-8 June 2007)

Title: Trans Fatty Acids and Radical Stress

43) Melusyn Workshop: Synchrotron Radiation Based Radiobiology (Saint-Aubin,

France, 25-26 June 2007)

Title: Trans Fatty Acids and Radical Stress

44) 9th Latin American Conference on Physical Organic Chemistry (Córdoba,

Argentina, 30 Sept. - 05 Oct. 2007)

Title: Biomimetic Chemistry: Radical Reactions in Vesicles Suspensions

45) Oxygen, Stress and Lipids (Dubrovnik, Croatia, 25-27 October 2007)

Title: Trans fatty acids and radical stress

46) ESOF 2008. Workshop on “Fats: the bad, the good and the ugly” (Barcelona, Spain,

19 July 2008)

Title: Trans fatty acids: From nutrition to radical stress

47) 8th International Conference on Pulse Investigations in Chemistry, Biology and

Physics PULS'2008 (Kraków, Poland, 6-12 September, 2008)

Title: One-electron reduction of 8-bromopurine nucleosides and excess electron

transfer through DNA

48) COST Action CM0603: WG1 Meeting, Consiglio Nazionale delle Ricerche

(Bologna, Italy, 11-12 February 2008)

Title: Common Antioxidant as Inhibitors of the Radical-Based Lipid Isomerization

49) COST Action CM0603: WG4 Meeting, Hotel Stefanie (Vienna, Austria, 29 Feb. - 1

March 2008)

66

Title: Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions

50) COST Action CM0603: WG2 Meeting, Facultat de Biologia, Universitat de

Barcelona (Barcelona, Spain, 6-7 March 2008).

Title: Reductive Modification of Methionine and Cysteine Residues in Peptides and

Proteins

51) COST Action CM0603: WG3 Meeting. Department of Chemistry and Pharmacy,

LMU Munich (Munich, Germany, 14-15 March 2008)

Title: 5’,8-Cyclopurine Lesions

52) COST Action CM0603: WG3 Meeting. Centre de l’Ecole de Physique (Les

Houches, France, 17-19 January 2009)

Title: The Chemistry 5’,8-Cyclopurine Lesions

53) 8th Winter Research Conferences on “Oxidatively DNA Damage (Les Houches,

France, 19-23 January 2009)

Title: Revising the Reactions of Hydroxyl Radicals and Hydrated Electrons with

Guanine Derivatives

54) Conferenza di DPM, Federchimica (Milan, Italy, 25 February 2009)

Title: La promozione dell’impresa Spin-off Lipinutragen

55) FEBS Advanced Lecture Course: Mechanisms and Consequences of Free Radical-

Mediated Oxidative Protein Modification (Antalya, Turkey, 15-20 April 2009).

Title: Desulfurization reactions of Met and Cys residues under reductive radical

stress

56) FEBS Advanced Lecture Course: Mechanisms and Consequences of Free Radical-

Mediated Oxidative Protein Modification (Antalya, Turkey, 15-20 April 2009).

Title: Free radical-mediated oxidative modifications of Met and Cys residues

67

57) COST Action CM0603: Joint WG1/WG2 meeting, Lordos Beach Hotel (Larnaca,

Cyprus, 4 – 6 May 2009)

Title: The reaction of thiyl radicals with PUFA: time-resolved experiments and

product studies

58) COST Action CM0603: Joint WG4/WG2 meeting, Ramada Hotel, (Balaton Lake,

Hungary, 22 – 24 May 2009).

Title: The reaction of thiyl radicals with PUFA: completing the picture

59) Organic Free Radicals Ottawa 2009 (OFRO-2009), Ottawa University (Ottawa,

Canada, 26 – 30 July 2009)

Title: Tautomerism in the Guanyl Radical

60) 26th Miller Conference on Radiation Chemistry (Keszthely, Hungary, 28 Aug. – 2

Sept. 2009)

Title: Tautomerism in the Guanyl Radical

61) 1st International Congress of Fatty Liver and Metabolic Syndrome (Budapest,

Hungary, 12-14 November 2009).

Title: Trans fatty acids in membranes: from nutrition to radical stress

62) NUTRACEUTICA: svipuppo e prospettive (CNR, Roma, Italy, 18 Novemver 2009)

Title: Dalla ricerca chimica ad un'impresa spin-off nel campo

Lipidomico/Nutraceutico

63) Cellular radical stress and related biomarkers – COST Action CM0603 (University

of Athens, Greece, 22 –24 February 2010)

Title: Radiation Chemical Studies of Methionine in Aqueous Solution:

Understanding the Role of Molecular Oxygen

64) Damages induced in biomolecules by low and high energy radiations – COST

Action CM0603 & MELUSYN (FIAP Jean Monnet - Paris, France, 9-12 March

2010)

68

Title: The Reaction of Hydroxyl Radicals with Guanine Derivatives

65) BioInItaly Investiment Forum 2010 (Milano, Italy, 19 – 20 April 2010)

Title: Lipinutragen spin-off del CNR

66) Obesità giovanile: alimentazione e sport insieme per la salute (Tenuta di

Sarramarina, Matera, Italy, 22 Maggio 2010)

Title: Acidi grassi trans: dall’alimentazione allo stress ossidativo

67) 4th Annual Progress Conference, COST–Chemistry and Molecular Sciences and

Technologies (Mediterranean Beach Hotel, Limassol, Cyprus, 3 – 5 June 2010).

Title: Free Radicals in Chemical Biology – CM0603

68) Lipid Oxidation, Human Diseases and Aging (University of Turin, Italy, 16 – 18

June, 2010)

Title: Lipid modification and radical stress in membranes

69) Topical issues of physical-organic, synthetic and medicinal chemistry (Ufa State

Petrolium Technological University, Ufa, Russia, 21 – 24 September 2010)

Title: Biomimetic models of free radical stress and related biomarkers

70) Workshop: Natural products as drugs and lead for drugs (Orthodox Academy of

Crete, Greece, 12 – 15 October 2010)

Title: Synthetic and mechanistic pathways of purine 5’,8-cyclonucleoside: The role

in DNA

71) XV Congresso Annuale della Società Italiana per le Ricerche sulle Radiazioni

(l’Istituto Superiore di Sanità, Roma, Italy, 27 – 29 October 2010)

Title: Modelli biomimetici di stress radicalico e biomarcatori correlati

72) Corso ECM: Lipidomica, Nutrizione e Stress (Bologna, Italy, 20 November 2010)

Title: Acidi grassi trans nella nutrizione e nello stress cellulare

69

73) Workshop: Epigenetics - Bench to Bedside (Institute of Biophysics, Brno, Czech

Republic, 22 – 24 November 2010)

Title: Biomarkers of free radical stress

74) Radical stress and defenses – COST Action CM0603 (Boğaziçi University,

Istanbul, Turkey, 2 – 3 December 2010)

Title: The Reaction of Hydroxyl Radicals with Guanine Derivatives

75) SIRR Workshop on Stress Ossidativo: Danni, Conseguenze e Rimedi (Univerity of

Bologna, Italy, 27 May 2011)


76) Corso ECM: Lipidomica, Nutrizione e Nutraceutica (Bologna, Italy, 21 May 2011)

Title: Oli nella nutrizione e formazione di acidi grassi trans

77) 5th Annual Progress Conference, COST–Chemistry and Molecular Sciences and

Technologies (Ma’ale Hachamisha Hotel, Judean Hills, Israel, 2 – 4 June 2011).

Title: Free Radicals in Chemical Biology – CM0603

78) Free Radicals in Chemical Biology (Rudjer Boskovic Institute, Zagreb, Croatia, 14

– 17 June 2011)

Title: Biomimetic models of radical stress and related biomarkers

79) 17th European Symposium on Organic Chemistry (ESOC) (Creta Maris Hotel,

Crete, Greece, 10 – 15 July 2011)


80) 16th International Symposium On Silicon Chemistry (ISOS) (McMaster University,

Hamilton, Canada, 14 – 18 August 2011)

Title: The (TMS)3SiH reagent in recent applications

81) 14th International Congress of Radiation Research (ICRR) (The Palace of Culture

and Science, Warsaw, Poland, 28 August – 1 September 2011)

70

Title: Chemical radiation studies related to radical-based DNA damage

82) 14th European Conference on the Spectroscopy of Biological Molecules (ECSBM)

(University of Coimbra, Portugal, 29 August – 3 September 2011)


83) 3rd International MELODI Workshop (Istituto Superiore di Sanità, Rome, Italy, 2 –

4 November 2011)

Title: Biomimetic models of radiation-induced radical stress and biomarker

discovery

84) International Conference on Metabolomics & System Biology (San Francisco

Airport Marriott, USA, 20 – 22 February 2012)

Title: Geometrical isomers of unsaturated fatty acids as markers of free radical

stress

85) COST-Chemistry and Molecular Science and Technologies, Domain Committee

Meeting (Seville, Spain, 15 March 2012)

Title of the proposal: Biomimetic Radical Chemistry

86) Emerging Companies: meet the innovation (CNR, Roma, Italy, 23 – 24 May 2012)


87) Corso ECM: Lipidomica e Sovrappeso (Bologna, Italy, 26 May 2012)

Title: Acidi grassi trans: biomarcatori di stress e ruolo nell’obesità

88) Congresso Nazionale della Divisione di Chimica Industriale (Firenze, Italy, 11 – 14

June 2012)


89) 11th International Symposium on Organic Free Radicals (Bern, Switzerland, 1 – 5

July 2012)


71

90) 244th National of the American Chemical Society (Philadelphia, USA, 19 – 23

August 2012)

Title: Bio-inspired synthetic strategies of purine 5’,8-cyclonucleoside derivatives

72

Invited Lectures at Institutions

(The list of conferences prior to 1991 is not available)

1) 1 March 1991. Facultè des Sciences saint-Jerome, Université D' Aix-Marseille III

(France).

Title: The design of silanes with different hydrogen donating abilities

2) 4 March 1991. Institut de Chimie Fine, Université Montpellier II (France).


3) 24 April 1991. Dipartimento di Chimica e Chimica Industriale, Università di Pisa

(Italy).

Title: Organosilani come agenti riducenti per via radicalica

4) 27 May 1991. Institut für Organische Chemie der Universität Basel (Switzerland).

Title: Recent advances in the chemistry of tris(trimethylsilyl)silane.

5) 18 June 1991. In occassione delle lezioni tenute dal Prof. D. H. R. Barton per

l' Accademia Nazionale dei Lincei, Sala Congressi del CNR (Milan, Italy).


6) 24 November 1991. Istituto di Chimica Farmaceutica e Tecnica Farmaceutica,

Università di Perugia (Italy).

Title: Organosilani come agenti riducenti per via radicalica.

7) 26 November 1992. Istituto per la Chimica di Molecole d' interesse Biologico, CNR,

Arco Felice (Italy).

Title: Organosilani come agenti riducenti per via radicalica

8) 5 February 1993. Additives Division, Ciba-Geigy Limited, Marly (Switzerland).

Title: Organosilanes as radical-based reagents in organic synthesis

9) 10 March 1993. Ciba-Geigy S.p.A., Pontecchio Marconi, Bologna (Italy).

73


10) 22 April 1993. Menarini Industrie Farmaceutiche Riunite S. r. l., Firenze (Italy).


11) 20 October 1993. Dipartimento di Chimica Organica, Università di Ferrara (Italy).


12) 7 December 1993. Centre de Recherches Pierre Fabre, Castres (France)


13) 29 March 1994. Department of Chemistry, University of Pittsburgh (USA)

Title: Acyl Radicals: Theory, Kinetics and New Synthetic Strategies

14) 31 March 1994. Department of Chemistry, University of Pittsburgh (USA)


15) 19 January 1995. Chemistry Department, University of Ioannina (Greece).

Title: Organosilanes as radical-based reagents in synthesis

16) 4 April 1995. Institut de chimie organique, Université de Fribourg (Switzerland).

Title: Organosilicon reagents designed for radical chain reactions

17) 3 January 1996. Department of Chemistry, University of California, Berkeley

(USA).

Title: Design of organosilanes for radical-based synthetic applications

18) 9 January 1996. Department of Chemistry, University of Stanford (USA).

Title: Design of organosilanes for radical-based synthetic applications

19) 23 April 1996. Department of Chemistry, University of Pittsburgh (USA).

Title: Poly(hydrosilane)s

74

20) 24 April 1996. Department of Chemistry, University of Pittsburgh (USA).


21) 26 April 1996. Radiation Laboratory, University of Notre Dame (USA).


22) 29 April 1996. Department of Chemistry, Wayne State University, Detroit (USA).


23) 3 May 1996. Additives Division, Ciba-Geigy, Ardslaey (NY) (USA).


24) 20 May 1996. Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia

(Italy).

Title: Chimica dei radicali liberi correlata alla posizione anomerica di nucleosidi

25) 17 July 1996. Dipartimento di Chimica, Università degli Studi di Pisa (Italy).

Title: Poli(sililidruri) compatibili con l’ambiente

26) 4 November 1996. Additives Division, Ciba-Geigy, Marly (Switzerland).


27) 28 May 1997. Department of Chemistry, University of Waterloo (Canada).

Titolo: Free radical chemistry associated with the C1' position of nucleosides

28) 3 October 1997. Ciba Specialty Chemicals, Marly (Switzerland).

Title: Acyl radicals: from elementary reactions to their role in polymer modification

29) 4 December 1997. Laboratoire de Chimie Moleculaire Organique, Universite d'Aix-

Marseille 3 (France).


30) 8 June 1998. Ciba Specialty Chemicals, Marly (Switzerland).

75

Title: Chemistry of acyl radicals

31) 8 June 1998. Societè Fribourgeoise de Chimie, Université de Fribourg

(Switzerland).


32) 3 July 1998. Highlights on Radical Reactivity, Area delle Ricerche CNR, Bologna

(Italy).

Title: How the radical clock methodology can be applied for determining the rate

constants of the reactions of alkyl radicals with thiols

33) 8 October 1998. Department of Chemistry, Northwestern University, Evanston

(USA).

Titolo: Free radical chemistry associated with the C1' position of nucleosides

34) 9 October 1998. Chemistry Department, University of Illinois, Chicago (USA).


polymer application

35) 13 October 1998. Department of Chemistry, Wayne State University, Detroit

(USA).


polymer application

36) 4 December 1998. Laboratoire de Chimie Organique de Synthèse, Université Pierre

et Marie Curie - Paris VI, (France).


37) 11 March 1999. Chemistry Department, University of Wisconsin (USA).

Title: Recent advances in free-radical chemistry of organosilanes

38) 15 March 1999. Chemistry Department, University of Illinois (USA).


76

39) 17 March 1999. Chemistry Department, Ohio State University (USA).

Title: Free radical chemistry associated with organosilanes: From reagent design to

polymer application

40) 27 September 1999. Institute of Organic Chemistry, Russian Academy of Science,

Ufa (Russia).

Title: Free radical chemistry associated with organosilanes: From reagent design to

polymer application

41) 4 October 1999. Institute of Chemical Physics, Russian Acad. of Science,

Chernogolovka (Russia).

Title: Free radical chemistry associated with organosilanes

42) 25 November 1999. Chemistry Griffith University, Brisbane (Australia).


43) 29 November 1999. Heart Research Institute, Sydney (Australia).

Title: The thiyl radical mediated cis/trans isomerization of fatty acid residues in

lipids

44) 9 December 1999. Research School of Chemistry, Australian National University,

Canberra (Australia).


45) 16 December 1999. CSIRO Molecular Sciences, Melbourne (Australia).


46) 13 April 2000. Departement de Synthese Organique, Ecole Polytechnique, (France).


lipids

47) 17 April 2000. Université Pierre et Marie Curie (Paris VI) (France).

77


lipids

48) 18 April 2000. Institute de Chimie Moléculaire d'Orsay, Université Paris-sud

(France).


lipids

49) 13 February 2001. Institut für Polymere, ETH-Zentrum, Zürich (Switzerland).

Title: The cis-trans isomerization of unsaturated fatty acid residues in lipids

catalyzed by thiyl radicals

50) 15, February 2001. Dipartimento di Chimica Organica e Biochimica, Università

degli Studi di Napoli “Federico II” (Italy).

Title: Studi modello del danneggiamento del DNA per via radicalica

51) 10 May 2001. Laboratorio di Immunologia e Biotecnologia Pediatrica, Università di

Roma “Tor Vergata” (Italy).

Title: Aspetti chimici e biologici di acidi grassi a configurazione trans come

costituenti dei lipidi

52) 24 May 2001. Institute of Organic Chemistry, Polish Academy of Sciencies,

Warsaw (Poland).

Title: Organosilanes as radical based reducing agents

53) 28 May 2001. Department of Organometallic Chemistry, Adam Mickiewicz

University, Poznan, (Poland).


54) 29 May 2001. Department of Bioorganic Chemistry, Polish Academy of Sciencies,

Lodz (Poland).

Title: Synthesis of conformationally fixed nucleosides

78

55) 30 May 2001. Centre of Molecular and Macromolecular Studies, Polish Academy of

Sciencies, Lodz (Poland).


56) 11 December 2001. Institute de Tecnologia Quimica UPV-CSIC, Universidad

Politécnica de Valencia (Spain).

Title: Mechanistic aspects of C1' and C5' radicals in nucleosides

57) 18 December 2001. Centre de Biophysique Moléculaire, CNRS, Orléans (France).

Title: Mechanistic aspects of C1' and C5' radicals in nucleosides

58) 20 December 2001. Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-

Yvette (France).


59) 13 May 2002. Department of Chemistry, University of Athens (Greece).

Title: Mechanistic aspects of C1' and C5' nucleosidyl radicals

60) 20 October 2003. Department of Biochemistry, M. V. Lomonosov Moscow State

University (Russia).

Title: Cis-trans isomerization of unsaturated fatty acid residues by thiyl radicals:

The influence of phospholipid supramolecular organization.

61) 22 October 2003. Moscow Institute of Biochemical Physics, Russian Academy of

Science (Russia).

Title: Model studies of DNA damage: Selective generation and reactivity of sugar

carbon-centered radical.

62) 24 October 2003. Institute of Organic Chemistry, Russian Academy of Science, Ufa

(Russia).

Title: Cis-trans isomerization of unsaturated fatty acid residues by thiyl radicals:

The influence of phospholipid supramolecular organization.

79

63) 14 September 2004. Chemistry of Department, University of Munchen (Germany).

Title: Interaction of Hydrated Electrons with 8-Bromoadenine and 8-

Bromoguanine Derivatives

64) 15 September 2004. Chemistry of Department, University of Uppsala (Sweden).

Title: (TMS)3SiH in Consecutive Radical Reactions: Synthesis of Cyclonucleosides

65) 11 November 2004. Division of Molecular Material Science, Osaka City University

(Japan).


66) 12 November 2004. Institute of Scientific and Industrial Research, Osaka University

(Japan).

Title: Free Radical Chemistry in the Carbohydrate Moiety of Nucleosides. Model

Studies of DNA Damage


Derivatives. Application to the Excess Electron Transfer in Oligonucleostides

67) 13 November 2004. Department of Applied Chemistry, Osaka Prefecture University

(Japan).

Title: Organosilanes in Radical Chemistry: Principles, Methods and Applications

68) 18 November 2004. Department of Chemistry, Osaka Prefecture University (Japan).


69) 19 November 2004. Department of Chemistry, Kyoto University (Japan).


Derivatives. Application to the Excess Electron Transfer in Oligonucleostides

70) 14 January 2005. Institut für Anorganische Chemie, Technische Universität Graz

(Austria).


80

71) 27 May 2005. Dipartimento di Patologia Generale, Seconda Università degli Studi

di Napoli (Italy).

Title: Lipidi Trans e Stress Radicalico

72) 2 December 2005. Department of Chemistry, University of Aarhus (Denmark).

Title: Lipidi Trans: The Free Radical Path

73) 21 December 2005. Dipartimento di Chimica Generale, Università di Pavia (Italy).

Titolo: Lipidi trans: formazione per via radicalica e significato biologico

74) 15 June 2006. Institute of Biochemical Physics, Russian Academy of Science,

Moscow (Russia).

Title: Trans Lipids: the Free Radical Path

75) 19 June 2006. Institute of Problems in Chemical Physics, Russian Academy of

Science, Chernogolovka (Russia).

Title: Trans Lipids: the Free Radical Path

76) 9 October 2006. COST office, Brussels (Belgium)

Title: Free Radicals in Chemical Biology

77) 9 May 2007. Technische Universität Graz (Austria).

Title: Biomimetic Chemistry: Radical Reactions in Vesicles Suspensions

78) 28 September 2007. Universidad Nacional de Córdoba (Argentina)



79) 8 October 2007. Universidad de Belgrano (Buenos Aires, Argentina)

Title: Trans fatty acids and radical stress

80) 9 October 2007. Universidad de Belgrano (Buenos Aires, Argentina)

Title: Fate of C5’ radicals in DNA and 5’,8-cyclopurine lesions

81

81) 10 October 2007. Universidad de Buenos Aires (Argentina)



82) 25 February 2008. Istituto di Scienze e Tecnologie Molecolari, CNR, Milano (Italy)

Title: Acidi Grassi Trans e Stress Radicalico

83) 06 March 2008. Institute for Research in Biomedicine (IRB Barcelona), Parc

Científic de Barcelona (Spain).

Title: 5’,8-Cyclopurine Lesions: Chemistry and Biology

84) 17 March 2008. Université Pierre et Marie Curie (Paris, France).

Title: Free Radical Chemistry for Understanding Biologically Related Mechanisms

85) 17 April 2008. Department of Chemistry and Biochemistry, Florida State University

(Tallahassee, USA)

Title: One-Electron-Reduction of 8-Bromopurine Derivatives: A Palette of

Chemical Behavior Related to DNA

86) 21 April 2008. Chemistry Department, New York University (USA)


87) 24 April 2008. Department of Chemistry, Johns Hopkins University (Barltimore,

USA)


88) 19 May 2008. Organische Chemie, Technisch Universität Kaiserslautern

(Germany).

Title: Free Radical Chemistry for Understanding Biologically Related Mechanisms

89) 20 May 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany)

82

Title: One-Electron-Reduction of 8-Bromopurine Derivatives and Related Systems

(Part 1)

90) 29 May 2008. Organisch-Chemisches Institut, Universität Münster (Germany).

Title: One-Electron-Reduction of 8-Bromopurine Derivatives: A Palette of

Chemical Behavior Related to DNA

91) 02 June 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany)

Title: Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions

92) 17 June 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany)

Title: One-Electron-Reduction of 8-Bromopurine Derivatives and Related Systems

(Part 2)

93) 25 June 2008. Department of Chemistry, Aarhus University (Aarhus, Denmark)


94) 09 June 2009. Université Pierre et Marie Curie - Paris 6, (France)

Title: (Part A) Trans fatty acids: From nutrition to radical stress; (Part B) Trans

fatty acids: Radical reactions in solution and in vesicle suspensions

95) 16 June 2009. Université Pierre et Marie - Paris 6, (France)

Title: (Part A) Free radical-mediated oxidative modifications of Met and Cys

residues;

(Part B) Desulfurization of Met and Cys Residues under Reductive Radical Stress

96) 23 June 2009. Université Pierre et Marie Curie - Paris 6, (France)

Title: Mechanistic studies related to radical-based DNA damage

97) 10 June 2009. University Paris 7 - Diderot (France)


98) 19 June 2009. Université Paris-Sud, Orsay (France)

83

Title: Desulfurization of Met and Cys residues under reductive radical stress

99) 23 September 2009. Semenov Institute of Chemical Physics RAS, Moscow (Russia)

Title: Tandem protein/lipid damage and Protection for lipid geometric integrity

100) 30 September 2009. Chimica Industriale, University of Bologna (Italy)

Title: Ricerca su radicali liberi: un omaggio al professore Gian Franco Pedulli

101) 27 October 2009. Biochemistry Dept., Faculty of Pharmacy, University of Buenos

Aires (Argentina)


102) 26 November 2010. Dipartimento di Chimica, Università di Salerno, (Italy)


103) 5 April 2011. Laboratoire Lésions des Acides Nucléiques, CEA Grenoble (France).


104) 16 May 2011. Dipartimento di Scienze Farmaceutiche, University of Bologna

(Italy)


105) 19 May 2011. Dipartimento di Scienze Farmaceutiche, University of Napoli

“Federico II” (Italy)


106) 26 October 2011. UMR NutrPass, Montpellier (France).

Title: Geometrical isomers of unsaturated fatty acids as markers of free radical

stress

107) 18 November 2011. Department of Chemistry and Biochemistry, Florida

International University, Miami (USA)


84

108) 21 November 2011. Chemistry Department, New York University, New York, NY

(USA)


109) 22 November 2011. Chemistry Department, Brookhaven National Laboratory,

Upton, NY (USA)


110) 6 December 2011. School of Chemistry, Newcastle University (UK)


111) 13 February 2012. Department of Chemistry and Biochemistry, University of

California, San Diego, CA (USA)


112) 15 February 2012. Department of Chemistry, The Scripps Research Institute, La

Jolla, CA (USA)


113) 17 February 2012. Department of Chemistry and Biochemistry, University of

California, Reverside, CA (USA)


114) 19 April 2012. Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette

(France)


85

Visiting Scientist at Foreign Institutions 1) Division of Chemistry, National Research Council of Canada, Ottawa (Canada).

July – August 1986

Invited by Dr. David Griller

2) Department für Chemie der Universität Basel, (Svizzera).

February – July 1990

Invited by Prof. Bernd Giese

3) Department für Chemie der Universität Basel, (Svizzera).

May – June 1991 (NATO Senior Fellowship)

Invited by Prof. Bernd Giese

4) Visit at Russisn Academy of Sciences (RAS) in Ufa e Chernogolovka in the frame

of the bilateral agreement CNR / RAS.

September 27 - October 6, 1999

Invited by Prof. V. V. Shereshovets e Prof. E. T. Denisov

5) Wilsmore Fellow to the School of Chemistry, University of Melbourne (Australia).

November 1999 – January 2000

Invited by Prof. Carl. H. Schiesser

6) Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie

(Francia).

April 2000

Invited by Prof. Max Malacria

7) Visit at Polish Academy of Sciences (PAN) in Varsavia, Posnan e Lodz in the frame

of the bilateral agreement CNR / PAN.

May 24 – June 1, 2001

Invited by Prof. W. J. Stec

86

8) Center for Integrated Protein Science Munich, LMU Munich (Germany).

March, May and June 2008

Invited by Prof. Thomas Carell

9) Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie

(France).

June 2009

Invited by Prof. Max Malacria

87

Managerial Activity

The managerial activity of Dr. Chatgilialoglu concerns various functions, summarized

as follows:

a) Leader of the BioFreeRadicals group at CNR, ISOF in Bologna, with the task of

research planning and supervising, fund raising, strategy and decision making

b) Consulting and refereeing activities for companies and institutions

c) Responsible functions within European and international projects

d) President of the spin-off company Lipinutragen Srl (Bologna)

Team leader of the BioFreeRadicals group

The BioFreeRadicals group at ISOF (CNR) includes 5 permanent researchers and

temporary staff, consisting of pre- and post-doctoral fellows. In 2012 it counts a total of 9

people. The group works on a research project, approved by the CNR, concerning

“Biomimetic models of radical stress and related biomarkers”. The financial and human

resources for this project are based on the matching fund criteria. Therefore, the

managerial activity and group leadership of Dr. Chatgilialoglu are focused on: (i) high

level productivity, in terms of research results and publications; (ii) optimal fund raising,

in order to create the budget for satisfactory research and human resources.

A constant growth of scientific productivity has been maintained during the scientific

career of Dr. Chatgilialoglu, as depicted in the diagram of Figure 3. The impressive

quantity of the scientific peer-reviewed publications clearly reflects a strong and constant

focus on all research subjects of interest. The excellent standard of the research is

demonstrated by the fact that the papers appear in high impact journals and receive a

remarkable number of citations. The yearly distribution of citations is depicted in Figure

4. The unremitting efforts of cultural renovation and acquisition of multidisciplinary

competences have certainly contributed to these achievements. Also, great attention has

been devoted to maintaining active international scientific collaborations and

participation in exchange visiting programs, for establishing contacts among research

groups of different countries. This has been a great strategic help for the set-up of

efficient partnerships for increasing productivity and preparing network for research grant

applications.

88

Figure 3. Published items in each year up to April 2012 (Web of Science Citation Report)

Figure 4. Citations in each year up to April 2012 (Web of Science Citation Report).

Sum of the Times Cited: 6325; h-index: 38

The fund raising has also been an important part of the managerial activity, and in the

last years this aspect has become more and more crucial. Dr. Chatgilialoglu participated

to several research projects within the “V, VI and VII Framework Programs” of the

European Commission. He received financial support for the COST Action “Free

Radicals in Chemical Biology” for the period June 2007 – June 2011 and he has recently

been granted with a four year support for the COST Action “Biomimetic Radical

89

Chemistry” starting September 2012. He managed several European grants over the last

three Framework Programs and at the present is the scientist-in-charge of a two years

Marie Curie IEF (started April 2012). The role of Dr. Chatgilialoglu has nowadays

reached a wide recognition from the free radical chemistry community and from a

multidisciplinary context of European research.

Consulting and refereeing activity for institutions and companies

Dr. Chatgilialoglu also carried out consulting activity, especially with companies

involved in applications of free radical reactivity. These contracts were carried our

bringing financial resources for the CNR research group. The longest consulting period

concerned a six years contact with Ciba Geigy Ltd., with the results from this cooperative

endeavor in the field of polysilanes having been world-patented.

Dr. Chatgilialoglu plays a significant role in the scientific community as referee for

institutions and companies. The most important journals of the chemical field (i.e., J. Am.

Chem. Soc. and Angewandte Chemie) are constantly asking him for peer reviewing of

manuscripts submitted to them. He acted as Guest Editor for the journals Helvetica

Chimica Acta and Chimia. He was also nominated as foreign referee or opponent in

public dissertations for PhD degrees at several European universities (e.g., Uppsala,

Marseille, Paris, Valencia, Munich, Athens, Montpellier). In 2002 the Greek Ministry of

National Education and Religious Affairs appointed him to an international committee for

the evaluation of the “Post Graduate Curriculum Programs” offered by the Greek

Institution of Higher Education (AEI).

Responsible functions within European and international projects

Dr. Chatgilialoglu is very active in the relationship with foreign institutions and

research groups, in the firm belief that the strong interaction with several countries can

reinforce the scientific visibility of the Italian groups and create a critical mass for

important advances in science. The managerial activity involved leadership of several

projects at international levels concerning collaborative research grants and bilateral

scientific cooperation agreements. Among others, he was director of Summer Schools

within the frame of NATO Advanced Study Institutes in 1989 and 1994. He was also

responsible for three NATO Collaborative Research Grants (3-years-time duration each)

90

with American institutions. In all cases, he acted as both scientific and administrative

supervisor. He was the supervisor of two Individual Marie Curie Fellowship in 1996 and

2002, and one ongoing started April 2012. From 2002 to 2007 he participated to two

Marie Curie Research Training Networks. For the period 2007-2011 he acted as the chair

of the COST Action “Free Radicals in Chemical Biology” and a new COST Action on

“Biomimetic Radical Chemistry” is approved starting from September 2012 for four

years.

President of the spin-off company Lipinutragen Srl

The managerial activity in the last five years focused on the creation of a spin-off

company based on the research results in lipidomics strongly connected with health,

nutrition and quality of life. The research on the

lipidomics of radical stress and the formation of trans

lipids led to the setting up of an innovative analysis of

erythrocyte membranes, which is commercialized as a

preventive tool in medicine for ameliorating metabolic

status and quality of life. On December 2005,

Lipinutragen Srl (http://www.lipinutragen.it) was founded and Dr. Chatgilialoglu was

nominated President of this company. The marketing concerns the commercialization of

the lipidomic analysis, denominated FAT PROFILE® (European trade mark) to clients in

the sector of health care (medical doctors, medical centers, hospitals etc). Recently a new

product named FAT PHARMACY® has been launched in the pharmacies. The company

also produces a nutraceutical line, named Nutragenika, which represents the first

membrane-targeted nutraceuticals available in the market, and it is sold in the Italian

pharmacies. This entrepreneurial experience enriches his multidisciplinary skills

contributing to improve his formation in the field of science for business.

91

International Appointments

1) NATO Collaborative Research Grant n. 860678.

Title: Structural and chemical properties of some sulfur-containing intermediates

Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Dr. D.

Griller (Division of Chemistry, National Research Council of Canada).

Period: April 1986 - March 1989

2) Progetto Finalizzato Chimica Fine

Sottoprogetto Nuove sintesi: Metodologie e campi avanzati di sintesi organica

Title: Nuovi processi radicalici a catena selettivi

Period: 1989 – 1993

3) Director of NATO Advanced Study Institute

Title: Sulfur-Centered Reactive Intermediates in Chemistry and Biology

Maratea (Italy), 18 – 30 June 1989


Title: New Reagents for Radical Allylation.

Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Prof. D.

P. Curran (Department of Chemistry, University of Pittsburg, USA)

Period: April 1993 – March 1996

5) Director of NATO Advanced Study Institute

Title: Chemical Synthesis: Gnosis to Prognosis

Ravello (Italy), 8 – 19 May 1994

6) Marie Curie Individual Fellowships: Model studies on radical induced DNA

cleavage associated with the C-1’ position

Scientist in charge: Chatgilialoglu, C. Fellow: Gimisis, T.

Contracts No: ERBFMBICT950336

Period: February 1996 – January 1998.

92


Title: Free Radical Chemistry of the C1’ Position of Nucleosides.

Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Prof. M.

Newcomb (Chemistry Department, Wayne State University, USA)

Period: April 1997 - March 1999

8) COST Programme of European Commission.

Title: Radical Cascade Reactions (D12/0005/98)

Period: June 1998 – December 2002

9) Scientific cooperation agreement CNR/RAS (Russia).

Title: Nuovi sviluppi sulla reattività dei silani in reazioni radicaliche

Period: 1999–2001

10) Scientific cooperation agreement CNR/PAN (Poland).

Title: Riduzioni di composti organofosforici mediante reattivi organometallici.

Nuovi applicazioni.

Period: 2000–2002


Title: Studio del meccanismo e dei prodotti dell’ossidazione di nucleosidi con ozono

Period: 2002–2004

12) Marie Curie Individual Fellowships: Trans-unsaturated fatty acid residues in

phospholipids: chemical and biological aspects

Scientist in charge: Chatgilialoglu, C. Fellow: Samadi, A.

Contract No: HPMF-CT-2001-01313

Period: 01.01.2002 – 31.12.2003

13) Research Training Network: Sulfur radical chemistry and biological significance:

the protective and damaging roles of thiol and thioether radicals [SULFRAD]

Contract No: HPRN-CT-2002-00184

93

Period: 01.09.2002 — 28.02.2006

14) Research Training Network: Selective formation and biochemistry of oxidative

clustered DNA damage [CLUSTOXDNA]

Contract No: MRTN-CT-2003-505086

Period: 01.02.2004 – 31.07.2007


Title: Model studies of DNA radicals repair: H-atom abstraction from thiols

Period: 2005–2007

16) Chair of COST Action CM0603

Domain: Chemistry and Molecular Sciences and Technologies

Action Title: Free Radical in Chemical Biology (CHEMBIORADICAL)

Period: June 2007 – June 2011


Title: Markers of radical stress for membrane lipidomics

Period: 2008–2010

18) Scientific cooperation agreement CNR/CONICET (Argentina).

Title: Modified unsaturated lipids, radical-based tandem damage and their

applications

Period: 2009–2010

19) Chair of the 12th EUCHEM Conference on “Organic Free Radicals”

Bologna (Italy), June 28 – July 2, 2010

20) Management Committee Member of the Trans-Domain COST Action

CMST-TD0905

Action Title: Epigenetics: Bench to Bedside

Period: June 2010 – June 2014

94

21) MIUR – PRIN 2009

Title: Oxidative DNA damage: mechanisms and physico-chemical properties of

intermediates and products

Contract No: 2009K3RH7N

Period: 2011 – 2013

22) Marie Curie Actions – Intra European Fellowships (IEF): Formation and roles of

the 5',8-cyclo-2'-deoxyguanosine lesion (CYCLOGUO)

Scientist in charge: Chatgilialoglu, C. Fellow: Terzidis, M. A.

Contract No: PIEF-GA-2011-298555

Period: 01.04.2012 – 31.03.2014

23) Proposer of COST Action CM1203

Domain: Chemistry and Molecular Sciences and Technologies

Action Title: Biomimetic Radical Chemistry

Period: September 2012 – September 2016

95

Consulting activity

1) Guido Donegani (EniChem), Novara. Italy

January 1991 – March 1992

2) Ciba-Geigy Limited, Basel (Switzerland).

February 1994 – January 1996

3) CTU consulting for Tribunale di Milano, in the suit ELF Atochem Italia srl vs ICI

Imperial Chemical Industries LTD (1994-1996).

4) Ciba-Geigy Limited, Basel (Switzerland).

Mau 1996 – April 2000

5) BIOCHIMICI PSN DERMA SpA, Bologna (Italy).

June 2000 – December 2001

6) BIORAMA 2000 srl, Bologna (Italy).

January 2001 – December 2002

Documents

CV May 2012 - CNR · - Director of NATO Advanced Study Institute on Sulfur-Centered Reactive Intermediates in Chemistry and Biology (June 1989) - Visiting Scientist (University of