CURRICULUM VITAE David Randal Hessl, Ph.D. · 2015-02-18 · David R. Hessl, PhD, 2 2006 – 2008 . Assistant Professor of Clinical Psychiatry. Department of Psychiatry and Behavioral

CURRICULUM VITAE

David Randal Hessl, Ph.D.

Department of Psychiatry and Behavioral Sciences and MIND Institute

University of California Davis Medical Center 2825 50th Street

Sacramento, CA 95817 (916) 703-0249

[email protected]

EDUCATION Ph.D. University of Washington. Seattle, WA (1997) Major Area: Child Clinical Psychology Minor Area: Developmental Psychology Advisor: Geraldine Dawson, Ph.D. M.S. University of Washington. Seattle, WA (1995) Major Area: Child Clinical Psychology B.A. University of California, Los Angeles. Los Angeles, CA (1989) Major: Psychology ADDITIONAL TRAINING

1996 – 1997 APA Accredited Internship. Lucile Salter Packard Children’s Hospital

at Stanford and The Children’s Health Council Consortium, Stanford and Palo Alto, CA.

1997 - 1998 MacArthur Foundation Post-Doctoral Fellowship. Institute of Human

Development, University of California, Berkeley, CA.

ACADEMIC POSITIONS 2014 – present Professor of Clinical Psychiatry. Department of Psychiatry and

Behavioral Sciences and MIND Institute, University of California Davis School of Medicine, Sacramento, CA.

2008 – 2014 Associate Professor of Clinical Psychiatry. Department of Psychiatry

and Behavioral Sciences and MIND Institute, University of California Davis School of Medicine, Sacramento, CA.

David R. Hessl, PhD, 2

2006 – 2008 Assistant Professor of Clinical Psychiatry. Department of Psychiatry

and Behavioral Sciences and MIND Institute, University of California Davis School of Medicine, Sacramento, CA.

2003 – 2006 Assistant Clinical Professor. Department of Psychiatry and Behavioral

Sciences and MIND Institute, University of California Davis School of Medicine, Sacramento, CA.

2002 – 2003 Psychologist II. MIND Institute, University of California Davis School

of Medicine, Sacramento, CA. 1998 - 2001 Research and Clinical Psychologist. Behavioral Neurogenetics Research

Center, Division of Child Psychiatry, Stanford University School of Medicine, Stanford, CA.

ACADEMIC AWARDS AND FELLOWSHIPS 1988 Honors in Psychology, University of California, Los Angeles 1991-1996 NIMH Graduate Student Research Fellowship, University of Washington 1994 Department of Psychology Dissertation Award, University of Washington 1997-1998 MacArthur Foundation Post-Doctoral Fellowship, Institute of Human

Development, University of California, Berkeley 2003 Joe P. Tupin Research Award, Department of Psychiatry, U.C. Davis 2004 Co-Recipient, National Fragile X Foundation Hagerman Award, for

contribution to the discovery of Fragile X-Associated Tremor/Ataxia Syndrome

2006 U.C. Davis Imaging Research Center Award 2007-2008 MIND Institute Pilot Research Grant Award 2008 U.C. Davis Academic Senate Research Travel Award 2008 U.C. Davis finalist – John Merck Scholars Program, Biology of Developmental Disabilities in Children 2009 Dean’s Team Award for Excellence, U.C. Davis School of Medicine 2012 Jarrett Cole Clinical Award, National Fragile X Foundation, for

“Dedicated Service to Families in the Worldwide Fragile X Community”

COMMITTEES AND SERVICE 2004 - Member, Human Development Graduate Group, UC Davis 2009 - Scientific and Clinical Advisory Committee, National Fragile X

Foundation 2008 - 2011 Member, Admissions Committee, U.C. Davis School of Medicine 2011 - Member, Committee on Student Progress, U.C. Davis School of Medicine 2008 - Co-Chair, Interview Subcommittee, Admissions Committee, U.C. Davis

School of Medicine


2009 University of California, Davis Health System Centennial Event Panelist, Cornell Club, New York, NY and Capitol Visitor Center, Washington, DC

2010 - Member, Town Hall Committee, MIND Institute, U.C. Davis 2010 - Member, Research IV Planning Committee, U.C. Davis School of

Medicine 2011 - 2014 Member, Committee on Student Progress, U.C. Davis School of Medicine 2013 - Specialty Advisor, UC Davis School of Medicine 2014 - Member, Committee on Research, U.C. Davis School of Medicine 2014 - Member, Clinical Trials Committee, Fragile X Clinical and Research

Consortium 2015 - Member, Neuroscience Graduate Group, UC Davis

PANELS AND ADVISORY POSITIONS • Member, Adolescents and Adults Projects Team, National Fragile X Foundation • Reviewer, Social Sciences and Humanities Research Council of Canada • Member, NIH Fragile X Research Coordinating Group • Member, Fragile X Clinical & Research Consortium Executive Council • Advisory Panelist, NICHD Outcome Measures for Clinical Trials with Children with Fragile X

Syndrome • Invited Participant, NIH Research Plan for Fragile X Syndrome and Associated Disorders (2008) • Panelist, “How to Develop an Interdisciplinary Program of Research”, NIH Interdisciplinary

Training Conference on Developmental Disabilities, Annapolis, MD • Invited Participant, NIH Research Plan for Fragile X Syndrome and Associated Disorders (2012) • Clinical Trials Consultant, Hoffman LaRoche • Clinical Trials Consultant, Novartis • Clinical Trials Consultant, Seaside Therapeutics • Invited Expert Panelist, “The Future of Fragile X: Center for Disease Control Public Health

Research Agenda”, Atlanta (2014)

COMMUNITY SERVICE • “A Conversation Between a Researcher and a Parent of a Child with Autism”, Access To Care,

Bayside Church, Roseville, CA • Donation of an in-home evaluation of a child with fragile X syndrome in Iowa, to benefit the

National Fragile X Foundation, 2007 • Donation of an in-home evaluation of two children with fragile X syndrome in Missouri, to

benefit the National Fragile X Foundation, 2008 • Donation of an in-home evaluation a child with fragile X syndrome in Mississippi, to benefit the

National Fragile X Foundation, 2011 • Provided consultation in an autism clinic, in association with the First Annual Autism

Conference, Dubai, United Arab Emirates, 2005


ACADEMIC PROFESSIONAL SERVICE Editorial Board Member – Journal of Neurodevelopmental Disorders Ad Hoc Reviewer • Acta Psychiatrica Scandinavica • American Journal on Intellectual and Developmental Disabilities • American Journal of Medical Genetics Part B:Neuropsychiatric Genetics • American Journal of Psychiatry • Annals of Neurology • Autism Research • Behavior Genetics • Behavioral Brain Research • Genes, Brain and Behavior • Biological Psychiatry • Child Development • Development and Psychopathology • International Journal of Psychophysiology • Journal of Autism and Developmental Disorders • Journal of Child Psychology and Psychiatry • Journal of Intellectual Disability Research • Neuropsychology • Pediatrics PROFESSIONAL AFFILIATIONS • American Psychological Association • Division 33 (Intellectual and Developmental Disabilities) – American Psychological Association • Society for the Study of Behavioural Phenotypes

LICENSURE Licensed Psychologist, State of California, #16690, 2000 - present

MENTORING AND TEACHING Dissertation Chair for Alyssa Chavez, Department of Human Development, U.C. Davis Dissertation Co-Chair for Susannah Cohen, Department of Human Development, U.C. Davis Mentor to Paula Wadell-Weinstein, M.D., Psychiatry Resident, U.C. Davis School of Medicine


Mentor to Lisa Cordeiro, Department of Human Development, U.C. Davis Mentor to Laurie Vismara, Ph.D., Autism Research Training Program, MIND Institute Mentor to Lisa Litt, Ph.D., Autism Research Training Program, MIND Institute Mentor to Andrea Schneider, Ph.D., Post-Doctoral Fellow, MIND Institute Co-Facilitator, Doctoring, U.C. Davis School of Medicine Faculty Member, Autism Research Training Program (PIs David Amaral and Sally Rogers) Mentor to Stephanie Sansone (Maltas), Department of Human Development, U.C. Davis, National

Science Foundation Graduate Research Fellowship Program, “The Fragile X Premutation and Differential Susceptibility to Immune Dysfunction: Examination of a Possible Gene-Environment Interaction with Chronic Stress”

Psy.D. Clinical Internship Supervisor to Amy Gaines Psy.D. Clinical Internship Supervisor to Corrisa Jacomini Dissertation Committee Chair, Stephanie Sansone, Human Development, UC Davis Dissertation Committee Member, Emily Halkett, Psychology, UC Davis GRANTS AND OTHER SUPPORT

Active NICHD – 1R01HD076189 A Cognitive Test Battery for Intellectual Disabilities Role: PI Amount: $3,145,326 total for 5 years Active The John Merck Fund: Developmental Disabilities Translational Research

Grant Cognitive Training for Fragile X Syndrome Role: PI Amount: $1,000,000 total for 4 years Active NIMH - 2R01MH078041-06 Trajectories and Markers of Neurodegeneration in Fragile X Premutation Carriers Role: Co-Equal PI with S. Rivera Amount: $2,970,846 for 5 years Active Centers for Disease Control Fragile X Clinical Research Consortium Role: UC Davis Site PI Active Department of Defense – 10600754 Treatment of Fragile X Syndrome with a Neuroactive Steroid Role: Co-PI Amount: $3,018,652 total for 4 years

Active NICHD R01HD036071 Genotype-Phenotype Relationships in Fragile X Families


Role: Co-Investigator Amount: $2,908,668 for 5 years

Active HRSA Controlled Trial of Sertraline in Young Children with Fragile X Syndrome Role: Co-Investigator Amount: $194,681 for year 1 of 3 Active National Fragile X Foundation

Extending Autism Behavioral Intervention to Young Children with Fragile X Syndrome Role: PI Amount: $50,000 for 1 year

Active MIND Institute Intellectual Disabilities Research Center (IDDRC) Pilot

Grant Event-related Oscillatory Brain Activity as Outcome Measure for Targeted

Treatment Trials in Fragile X Syndrome Role: Co-Investigator Amount: $30,000 for 1 year 2007-2013 NIMH - R01MH078041

Limbic System Function in Carriers of the Fragile X Premutation Role: PI Amount: $1,558,710 total for 5 years 2011-2013 NIMH - 3R01MH078041-04S1 (Competitive Revision). Limbic System Function in Carriers of the Fragile X Premutation Role: PI Amount: $766,250 total for 2 years 2008-2013 NICHD - R01HD059967-01A2

An Open Resource for Autism iPSCs and Their Derivatives PI: Charles Schwartz, UCI Role: Co-Investigator Amount: $501,923

2007-2012 NIA - RL11RL1AG032115-01 NeuroTherapeutics Research Consortium Characterization and Treatment of CNS Abnormalities in Premutation

Carriers Overall PI: Paul Hagerman; Component PI: Randi Hagerman Role: Co-Investigator Amount: $6,711,049 total for 5 years 2010-2011 National Fragile X Foundation


A Double Blind Randomized Controlled Cross Over Trial of Minocycline in Children with Fragile X Syndrome PI: Randi Hagerman Role: Co-PI Amount: $75,000

2009-2011 MIND Institute Pilot Research Grant Candidate Gene Association Analysis of the FMR1 Pathway in Idiopathic Autism Spectrum Disorders PI: Simeon Boyd Role: Co-Investigator Amount: $50,000

2009 Seaside Therapeutics A Double-Blind, Placebo-Controlled, Crossover, Flexible-Dose Evaluation of the Efficacy, Safety, and Tolerability of STX209 in the Treatment of Irritability in Subjects with Fragile X Syndrome PI: Randi Hagerman Role: Co-Investigator Amount: $10,244 per patient

Completed Hoffman-LaRoche A randomized, double-blind, placebo-controlled, pharmacokinetic, safety and tolerability, and exploratory efficacy and pharmacodynamic effects study of RO4917523 in adult patients with fragile X syndrome Role: Co-Investigator Amount: $337,158

2010 FRAXA Research Foundation Aberrant Behavior Checklist in Fragile X Syndrome Role: PI Amount: $10,000

2007-2009 NICHD - R21MH080025 Amygdala Function in Children and Adolescents with Fragile X Syndrome PI: Susan Rivera Role: Co-Investigator Amount: $417,000 total for 2 years

2009-2010 NCRR/NICHD A Toolbox of Outcome Measures for Targeted Treatment Trials in

Children – UC Davis Clinical and Translational Science Center Supplement

PI: Lars Berglund Role: Co-Investigator


Amount: $350,380 2005-2010 NIMH - 1K23MH77554: Patient-Oriented Career Development Research

Grant Genetics and Physiology of Social Anxiety in Fragile X Role: PI Amount: $771,837 total for 5 years 2008-2009 Neuropharm, Ltd. - NPL-2009-2-FEN-001 An Open Label Exploratory Study to Investigate the Effect of Fenobam

Monohydrate (Fenobam 50 mg – 150 mg single dose) on Prepulse Inhibition Tests and Continuous Performance Tasks, in Adults with Fragile X Syndrome

Role: Co-PI Amount: $53,835 for one year 2007-2008 MIND Institute Pilot Research Grant Sensorimotor Gating in Idiopathic Autism and Autism in Fragile X

Syndrome Role: PI Amount: $50,000 for 1 year 2007-2008 MIND Institute Pilot Research Grant Y Chromosome Gene Expression in Autism Spectrum Disorders

PI: Robin Hansen Role: Co-Investigator Amount: $24,920 for 1 year 2006 -2007 Children’s Miracle Network

Autistic Spectrum Disorders and Behavioral Problems in Male Children with Sex Chromosome Aneuploidy

Role: PI Amount: $60,000 total for 2 years 2005 - 2006 National Fragile X Foundation Hyperarousal and Aggressive Behavior in Fragile X Syndrome Role: PI Amount: $30,000 for 1 year 2002 - 2005 NIH Grant #HD36071: Genotype-Phenotype Relationships in Fragile X

Families PI: Randi Hagerman, M.D. Role: Psychologist, 40% support

2004 – 2005 NIH Grant # 1 R01 NS044299-01: Action Tremor and Dementia in Male

Carriers of Fragile X


PI: Jim Grigsby, Ph.D. Role: Psychologist, 10% support 2003 – 2004 Joe P. Tupin Award – Department of Psychiatry, U.C. Davis: Genetic,

Physiological, and Neuroendocrine Correlates of Anxiety in Fragile X Syndrome

Amount of award: $35,000 Role: P.I.

PEER REVIEWED JOURNAL ARTICLES

1. Au J, Berkowitz-Sutherland L, Schneider A, Schweitzer JB, Hessl D, & Hagerman RJ (2014). A feasibility trial of Cogmed working memory training in fragile X syndrome. Journal of Pediatric Genetics 3(3).

2. Sansone SM, Schneider A, Bickel E, Berry-Kravis E, Prescott C, & Hessl D (2014). Improving IQ measurement in intellectual disabilities using true deviation from population norms. Journal of Neurodevelopmental Disorders 6(16), 1-14.

3. McCormick C, Hessl D, Macari SL, Ozonoff S, Green C, Rogers SJ (2014). Electrodermal and behavioral responses of children with autism spectrum disorders to sensory and repetitive stimuli. Autism Research 7(4), 468-480.

4. Lozano R, Summers S, Lozano C, Mu Y, Hessl D, Nguyen D, Tassone F, & Hagerman RJ (2014). Association between macroorchidism and intelligence in FMR1 premutation carriers. American Journal of Medical Genetics 164A(9), 2206-2211.

5. Brick DJ, Nethercott HE, Montesano S, Banuelos MG, Stover AE, Schutte SS, O’Dowd DK, Hagerman RJ, Ono M, Hessl D, Tassone F, & Schwartz PH (2014). The autism spectrum disorders stem cell resource at CHOC Children’s Hospital of Orange County: Implications for disease modeling and drug discovery. Stem Cells Translational Medicine 3, 1275-1286.

6. Ballinger EC, Cordeiro L, Chavez AD, Hagerman RJ, & Hessl D (2014). Emotion potentiated startle in fragile X syndrome. Journal of Autism and Developmental Disabilities 44(10), 2536-2546.

7. Loesch DZ, Bui MQ, Hammersley E, Schneider A, Storey E, Stimpson P, Burgess T, Francis D, Slater H, Tassone F, Hagerman RJ, & Hessl D (2014). Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion. Clinical Genetics.

8. Wheeler A, Raspa M, Bann C, Bishop E, Hessl D, Sacco P, & Bailey D (2014). Anxiety, attention problems, hyperactivity, and the Aberrant Behavior Checklist in fragile X syndrome. American Journal of Medical Genetics Part A, 164A, 141-155.

9. Cohen S, Masyn K, Mastergeorge A, & Hessl D (2015). Psychophysiological responses to emotional stimuli in children and adolescents with autism and fragile X syndrome. Journal of Clinical Child and Adolescent Psychology 44(2), 250-263. PMID: 24156344.

10. Basuta K, Lozano R, Schneider A, Yrigollen CM, Hessl D, Hagerman RJ, & Tassone F (2014). A family with two females compound heterozygous for the FMR1 premutation. Clinical Genetics 85(5), 458-463. PMID: 23786467.


11. Schneider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman RJ, & Hessl D (2013). Electrocortical changes associated with minocycline treatment in fragile X syndrome. Journal of Psychopharmacology, 27(10), 965-963. PMID: 23981511.

12. Wang JY, Hessl D, Schneider A, Tassone F, Hagerman RJ, & Rivera SM (2013). Fragile X-associated tremor/ataxia syndrome: Influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles. JAMA Neurology 70(8), 1022-1029. PMID: 23753897.

13. Berry-Kravis E, Hessl D, Abbeduto L, Reiss AL, Beckel-Michener A, & Urv TK (2013). Outcome measures for clinical trials in fragile X syndrome. Journal of Developmental and Behavioral Pediatrics, 34(7) 508-522. PMID: 24042082.

14. Russo-Ponsaran N, Yesensky J, Hessl D, & Berry-Kravis E (In press). Feasibility, reproducibility, and clinical validity of the Pediatric Anxiety Rating Scale – Revised for fragile X syndrome. American Journal on Intellectual and Developmental Disabilities 119(1), 1-16.

15. Schneider A, Seritan A, Tassone F, Rivera S, Hagerman RJ, & Hessl D (2013). Psychiatric features in high-functioning adult brothers with fragile X spectrum disorders. The Primary Care Companion for CNS Disorders, 15(2).

16. Wadell PM, Hagerman RJ, & Hessl D (2013). Fragile X syndrome: Psychiatric manifestations, assessment, and emerging therapies. Current Psychiatry Reviews, 9: 53-58.

17. Leigh MJS, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P, Tassone F, Rivera SM, Hessl D, & Hagerman RJ (2013). A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile X syndrome. Journal of Developmental and Behavioral Pediatrics, 34(3), 147-155. PMID: 23572165

18. Kim S, Burris J, Bassal F, Koldewyn K, Chattarji S, Tassone F, Hessl D, & Rivera SM (2012). Fear-specific amygdala function in children and adolescents on the fragile X spectrum: A dosage response of the FMR1 gene. Cerebral Cortex 24(3), 600-613. PMID: 23146966

19. Wang JM, Koldewyn K, Hashimoto R, Schneider A, Li L, Tassone F, Cheung C, Hagerman PJ, Hessl D, & Rivera SM (2012). Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Frontiers in Human Neuroscience, 2(6): 297. PMID: 23115550

20. Wang JY, Hessl D, Iwahashi C, Cheung K, Schneider A, Hagerman RJ, Hagerman PJ, & Rivera SM (2012). Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Neuroimage, 65: 288-298. PMID: 23063447

21. Berry-Kravis EM, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y, Nguyen DM, Gonzalez-Heydrich J, Wang PP, Carpenter RL, Bear MF, & Hagerman RJ (2012). Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, Phase 2 trial. Science Translational Medicine, 4(152): 152ra127. PMID: 22993294

22. Hamlin AA, Sukharev D, Campos L, Mu Y, Tassone F, Hessl D, Nguyen DV, Loesch D, & Hagerman RJ (2012). Hypertension in FMR1 premutation males with and without fragile X-associated tremor /ataxia syndrome (FXTAS). American Journal of Medical Genetics: Part A. 158A(6), 1304-1309. PMID: 22528549

23. Knox A, Schneider A, Abucayan F, Hervey C, Tran C, Hessl D & Berry-Kravis E (2012). Feasibility, Reliability, and Clinical Validity of the Tests of Attentional Performance for


Children (KiTAP) in Fragile X Syndrome (FXS). Journal of Neurodevelopmental Disorders 4: 2. PMID: 22958782

24. Chonchaiya W, Au J, Schneider A, Hessl D, Harris SW, Laird M, Nguyen DV, Mu Y, Tassone F, Hagerman RJ (2011). Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder. Human Genetics 131(4), 581-589. PMID: 22001913

25. Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E, Lachiewicz A, Brown EC, & Hessl D (2011). Psychometric study of the Aberrant Behavior Checklist in fragile X syndrome and implications for targeted treatment. Journal of Autism and Developmental Disorders 42(7), 1377-1392. PMID: 21972117

26. Wang JY, Hessl D, Hagerman RJ, Tassone F, & Rivera SM (2012). Age-dependent structural connectivity effects in fragile X premutation. Archives of Neurology, 69(4), 482-489. PMID: 22491193

27. Selmeczy D, Koldewyn K, Wang JM, Lee A, Harvey D, Hessl D, Tassone F, Adams P, Hagerman RJ, Hagerman PJ, & Rivera SM (2011). Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging and Behavior, 5(4), 285-294. PMID: 21786216

28. Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Tassone F, Hagerman PJ, & Rivera SM (2011). Deficient FMRP underlies amygdala dysfunction in carriers of the fragile X premutation. Biological Psychiatry, 70(9), 859-865. PMID: 21783174

29. Farzin F, Scaggs F, Hervey C, Berry-Kravis E, & Hessl D (2011). Reliability of eye tracking and pupillometry measures in individuals with fragile X syndrome. Journal of Autism and Developmental Disorders, 41(11), 1515-1522. PMID: 21267642

30. Cordeiro, L., Ballinger, E., Hagerman RJ, & Hessl D (2011). Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: Prevalence and characterization. Journal of Neurodevelopmental Disorders 3, 57-67. PMID: 21475730

31. Schneider, A., Ballinger, E., Chavez, A., Tassone F, Hagerman RJ, & Hessl D (2010). Prepulse inhibition in patients with fragile X-associated tremor ataxia syndrome. Neurobiology of Aging, 33(6), 1045-1053. PMID: 20961665

32. Chonchaiya, W., Tassone F, Ashwood, P., Hessl D, Schneider, A., Campos, L., Nguyen, D.V., Hagerman RJ (2010). Autoimmune disease in mothers with the FMR1 premutation is associated with seizures in their children with fragile X syndrome. Human Genetics, 30(6), 544-551. PMID: 20809278

33. Yuhas J, Cordeiro L, Tassone F, Ballinger L, Schneider A, Long JM, Ornitz EM, & Hessl D (2010). Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. Journal of Autism and Developmental Disorders, 41(2), 248-253. PMID: 20521090

34. Utari A, Adams E, Berry-Kravis E, Chavez A, Scaggs F, Ngotran L, Boyd A, Hessl D, Gane L, Tassone F, Tartaglia N, Leehey M & Hagerman RJ (2010). Aging in fragile X syndrome. Journal of Neurodevelopmental Disorders, 2(2), 70-76. PMID: 20585378

35. Ashwood P, Nguyen DV, Hessl D, Hagerman RJ, & Tassone F (2010). Plasma cytokine profiles in Fragile X subjects: Is there a role for cytokines in the pathogenesis? Brain, Behavior, and Immunity, 24(6), 898-902.

36. Schneider A, Hagerman RJ & Hessl D (2009). Fragile X syndrome: From genes to cognition. Special issue: Cognitive Profiles in Sex Chromosome Disorders. Developmental Disabilities Research Reviews, 15(4), 333-342. PMID: 20014363


37. Bourgeois JA, Seritan AL, Casillas EM, Hessl D, Schneider A, Yang Y, Kaur I, Cogswell JB, Nguyen DV, & Hagerman RJ (2011). Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers. Journal of Clinical Psychiatry, 72, 175-182. PMID: 20816038

38. Adams PE, Adams JS, Nguyen DV, Hessl D, Brunberg JA, Tassone F, Zhang W, Koldewyn K, Rivera SM, Grigsby J, Zhang L, DeCarli C, Hagerman PJ, & Hagerman RJ (2010). Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. American Journal of Medical Genetics: Neuropsychiatric Genetics 3, 775-785.

39. Chonchaiya W, Utari A, Pereira GM, Tassone F, Hessl D, & Hagerman RJ (2009). Broad clinical involvement in a family affected by the fragile X premutation. Journal of Developmental and Behavioral Pediatrics, 30, 544-551.

40. Bourgeois J, Coffey S, Rivera SM, Hessl D, Gane LW, Tassone F, Greco C, Finucane B, Nelson L, Berry-Kravis E, Grigsby J, Hagerman PJ & Hagerman RJ (2009). The family of fragile X premutation disorders: Expanding the psychiatric perspective. Journal of Clinical Psychiatry 70(6) 852-862.

41. Farzin F, Rivera SM, & Hessl D (2009). Face processing in individuals with fragile X syndrome: An eye tracking study. Journal of Autism and Developmental Disorders, 39(6) 946-952.

42. Solomon M, Hessl D, Chiu S, Olsen E, & Hendren R (2009). Towards a neurodevelopmental model of clinical case formulation. Psychiatric Clinics of North America, 32(1) 199-211.

43. Zingerevich C, Greiss-Hess L, Lemons-Chitwood K, Harris S, Hessl D, & Hagerman RJ (2009). Motor abilities of children with fragile X syndrome. Journal of Intellectual Disabilities Research, 53(1), 11-18.

44. Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, Hutchinson J, Snape M, Tranfaglia M, Nguyen DV, & Hagerman RJ (2009). A pilot open-label singe-dose trial of Fenobam in adults with fragile X syndrome. Journal of Medical Genetics, 46(4) 266-271. PMID: 19126569

45. Hagerman RJ, Berry-Kravis E, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C, Kaufmann WE, Hessl D, Visootsak J, Picker J, Gane LW, & Tranfaglia M (2009). Advances in the treatment of fragile X syndrome. Pediatrics, 123(1), 378-390.

46. Hessl D, Nguyen DV, Green C, Chavez A, Tassone F, Hagerman RJ, Senturk D, Schneider A, Lightbody A, Reiss AL & Hall S (2009). A solution to limitations of cognitive testing in children with intellectual disabilities: The case of fragile X syndrome. Journal of Neurodevelopmental Disorders, 1, 33-45. PMID: 19865612

47. Hessl D, Cordeiro L, Yuhas J, Campbell A, Ornitz E, Berry-Kravis E, Chruscinski E, Hervey C, Long JM, & Hagerman RJ (2009). Prepulse inhibition in fragile X syndrome: Feasibility, reliability and implications for treatment. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B(4) 545-553.

48. Harris SW, Hessl D, Bacalman S, Goodlin-Jones B, Ferranti J, Herman K, Tassone F, Barbato I, Hagerman PJ, & Hagerman RJ (2008) Autism profiles of males with fragile X syndrome. American Journal of Intellectual and Developmental Disabilities 113(6), 427-438.

49. Hagerman RJ, Berry-Kravis E, Hessl D, Coffey S, Schneider A, Nguyen DV, Hervey C, Hutchinson J, & Snape M (2008). Trial of fenobam, an mGluR5 antagonist, in adults with Fragile X Syndrome. Journal of Intellectual Disabilities Research, 52(10), 814.


50. Brouwer JR, Severijnen E, de Jong FH, Hessl D, Hagerman RJ, Oostra BA, & Willemsen R (2008). Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded CGG-repeat mouse model for fragile X-associated tremor/ataxia syndrome. Psychoneuroendocrinology, 33, 863-873.

51. García-Nonell C, Ratera ER, Harris S, Hessl D, Ono M, Tartaglia N, Marvin E, Tassone F, & Hagerman RJ (2008). Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder. American Journal of Medical Genetics, 146A(15), 1911-1916.

52. Koldewyn K, Hessl D, Adams J, Tassone F, Hagerman RJ, Hagerman PJ, & Rivera S (2008). Reduced hippocampal activation during recall is associated with elevated FMR1 mRNA and psychiatric symptoms in men with the fragile X premutation. Brain Imaging and Behavior, 2, 105-116.

53. Brega AG, Goodrich G, Bennett RE, Hessl D, Engle K, Leehey MA, Bounds LS, Paulich MJ, Hagerman RJ, Hagerman PJ, Cogswell JB, Tassone F, Reynolds A, Kooken R, Kenny M, & Grigsby J (2008). The primary cognitive deficit among males with fragile X-associated tremor/ataxia syndrome (FXTAS) is a dysexecutive syndrome. Journal of Clinical and Experimental Neuropsychology, 15, 1-17.

54. Soontarapornchai K, Maselli R, Fenton-Ferrell G, Tassone F Hagerman PJ, Hessl D, & Hagerman RJ (2008). Abnormal nerve conduction features in fragile X premutation carriers. Archives of Neurology 65(4), 469-498.

55. Grigsby J, Brega AG, Engle K, Leehey MA, Hagerman RJ, Tassone F, Hessl D, Hagerman PJ, Cogswell JB, Bennett RE, Cook K, Hall DA, Bounds LS, Paulich MJ & Reynolds A (2008). Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor/ataxia syndrome. Neuropsychology 22(1), 48-60.

56. Hessl D, Tassone F, Cordeiro L, Koldewyn K, McCormick C, Green C, Wegelin J, Yuhas J, & Hagerman RJ (2008). Aggression and stereotypic behavior in males with fragile X syndrome: Moderating secondary genes in a “single gene” disorder. Journal of Autism and Developmental Disorders 38(1), 184-189.

57. Bourgeois JA, Cogswell JB, Hessl D, Zhang L, Ono MY, Tassone F, Farzin F & Hagerman RJ (2007). Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome. General Hospital Psychiatry, 29(4), 349-356.

58. McConkie-Rosell A, Abrams L, Finucane B, Cronister A, Gane LW, Coffey SM, Sherman S, Nelson LM, Berry-Kravis E, Hessl D, Chiu S, Street N, Vatave A, & Hagerman RJ (2007). Recommendations from multi-disciplinary focus groups on cascade testing and genetic counseling for Fragile X associated disorders. Journal of Genetic Counseling 16(5), 593-606.

59. Solomon M, Hessl D, Chiu S, Hagerman RJ, & Hendren R (2007). A genetic etiology of PDD guides treatment. American Journal of Psychiatry 164(4): 575-580.

60. Grigsby J, Brega A, Leehey M, Goodrich G, Jacquemont S, Loesch D, Hagerman PJ, Cogswell J, Epstein J, Wilson R, Jardini T, Gould E, Bennett R, Hessl D, Cohen S, Cook K, & Hagerman, RJ (2007). Impairment of executive cognitive functioning in males with fragile X-associated tremor/ataxia syndrome (FXTAS). Movement Disorders, 22(5), 645-650.

61. Chiu S, Wegelin J, Blank J, Jenkins, Day J, Hessl D, Tassone F, & Hagerman RJ (2007). Early acceleration of head circumference in children with fragile X syndrome and autism. Journal of Behavioral and Developmental Pediatrics 28, 31-35.


62. Hessl D, Rivera SR, Koldewyn K, Cordeiro L, Adams J, Tassone F, Hagerman PJ, & Hagerman RJ (2007). Amygdala dysfunction in men with the fragile X premutation. Brain 130(2), 404-416.

63. Leehey M, Berry-Kravis E, Min S, Hall D, Rice C, Zhang L, Grigsby J, Greco C, Lara R, Cogswell J, Jacquemont S, Hessl D, Tassone F, Hagerman, RJ, & Hagerman, PJ (2007). Progression of tremor and ataxia in the fragile X-associated tremor/ataxia syndrome. Movement Disorders 22(2), 203-206.

64. Loesch DZ, Quang M, Dissanayake C, Clifford S, Gould E, Bulhak-Paterson D, Tassone F, Taylor A, Hessl D, Hagerman RJ, & Huggins R (2006). Molecular and cognitive predictors of the continuum of autistic behaviors in fragile X. Neuroscience and Biobehavioral Reviews 31, 315-326.

65. Cohen S, Maysn K, Adams J, Hessl D, Rivera S, Tassone F, Brunberg J, DeCarli C, Zhang L, Cogswell J, Loesch DZ, Leehey M, Grigsby J, Hagerman PJ, & Hagerman RJ (2006). Molecular and imaging correlates of the Fragile X-associated Tremor Ataxia Syndrome. Neurology 67(8),1426-1431.

66. Bourgeois JA, Farzin F, Brunberg JA, Tassone F, Hagerman PJ, Zhang L, Hessl D & Hagerman RJ (2006). Dementia with mood symptoms in a carrier of the fragile X-associated tremor/ataxia syndrome (FXTAS): Clinical intervention with donepezil and venlafaxine. The Journal of Neuropsychiatry and Clinical Neurosciences, 18(2), 171-177.

67. Farzin F, Perry H, Hessl D, Loesch DZ, Cohen J, Bacalman S, Gane LW, Tassone F, Hagerman PJ, & Hagerman RJ (2006). Autism spectrum disorders and attention deficit/hyperactivity disorder in boys with the fragile X premutation. Journal of Developmental and Behavioral Pediatrics, 27(2) S137-S144.

68. Hessl D, Glaser B, Dyer-Friedman J, & Reiss AL (2006). Social behavior and cortisol reactivity in children with fragile X syndrome. Journal of Child Psychology and Psychiatry, 47(6), 602-610.

69. Greco CM, Berman RF, Martin RM, Tassone F, Schwartz PH, Grigsby J, Hessl D, Becker EJ, Papazian J, Bacalman S, Leehey MA, Hagerman RJ, & Hagerman PJ (2006). Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain, 129, 243-255.

70. Hessl D, Tassone F, Loesch, DZ, Berry-Kravis E, Leehey M, Gane LW, Barbato I, Rice C, Gould E, Hall DA, Grigsby J, Wegelin JA, Harris S, Lewin F, Weinberg D, Hagerman PJ & Hagerman RJ (2005). Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B: 115-121.

71. Mothersead PK, Conrad K, Hagerman RJ, Greco CM, Hessl D, & Tassone F (2005). Grand rounds: An atypical progressive dementia in a male carrier of the fragile X premutation: An example of Fragile X-Associated Tremor/Ataxia Syndrome. Applied Neuropsychology 12(3), 169-78.

72. Hessl D, Deprey L, Ruiz L, Huff HN, & Hagerman RJ (2004). Vagus nerve stimulation in an adult male with fragile X syndrome. Mental Health Aspects of Developmental Disabilities, 7(3), 107-113.

73. Hagerman RJ, Leavitt BR, Farzin F, Jacquemont S, Greco CM, Brunberg JA, Tassone F, Hessl D, Harris SW, Zhang L, Jardini T, Gane LW, Ferranti J, Ruiz L, Leehey MA, Grigsby J, & Hagerman PJ (2004). Fragile X-Associated Tremor/Ataxia Syndrome


(FXTAS) in females with the FMR1 premutation. American Journal of Human Genetics, 74(5), 1051-1056.

74. Hessl D, Rivera SM & Reiss AL (2004). The neuroanatomy and neuroendocrinology of fragile X syndrome. Special issue: Fragile X syndrome: Frontiers of understanding gene-brain-behavior relationships. Mental Retardation and Developmental Disabilities Research Reviews, 10, 17-24.

75. Dawson G, Ashman SB, Panagiotides H, Hessl D, Self J, Yamada E & Embry L (2003). Preschool outcomes of children of depressed mothers: Role of maternal behavior, contextual risk, and children’s brain activity. Child Development, 74(4), 1158-1175.

76. Johnston C, Hessl D, Eliez S, Dyer-Friedman J, Blasey C, Glaser B, & Reiss AL (2003). Factors associated with parenting stress in mothers of children with fragile X syndrome. Journal of Behavioral and Developmental Pediatrics, 24(4), 267-275.

77. Glaser B, Hessl D, Dyer-Friedman J, Johnston C, Wisbeck J, Taylor A. & Reiss AL (2003). Biological and environmental contributions to adaptive behavior in fragile X syndrome. American Journal of Medical Genetics, 117A, 21-29.

78. Hessl D, Glaser B, Dyer-Friedman J, Blasey C, Gunnar M, Hastie T & Reiss AL (2002). Cortisol and behavior in fragile X syndrome. Psychoneuroendocrinology, 27, 855-872.

79. Carrion V, Weems C, Ray R, Glaser B, Hessl D, & Reiss AL (2002). Baseline cortisol in pediatric PTSD. Biological Psychiatry, 51, 575-582.

80. Dyer-Friedman J, Glaser B, Hessl D, Johnston C, Taylor A, Wisbeck J & Reiss AL (2002). Genetic and environmental influences on the cognitive outcomes of children with fragile X syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 41(3), 237-244.

81. Tamm L, Menon V, Johnston C, Hessl D, & Reiss AL (2002). fMRI study of cognitive interference processing in females with fragile X syndrome. Journal of Cognitive Neuroscience, 14, 160-171.

82. Hessl D, Dyer-Friedman J, Glaser B, Barajas G, Wisbeck J, Taylor A & Reiss AL (2001). The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome. Pediatrics, 108(5), p. e88.

83. Johnston C, Eliez S, Dyer-Friedman J, Hessl D, Glaser B, Blasey C, Taylor A, & Reiss AL (2001). Neurobehavioral phenotype in carriers of the fragile X premutation. American Journal of Medical Genetics, 103, 314-319.

84. Dawson G, Ashman SB, Hessl D, Spieker S, Frey K, Panagiotides H, & Embry L (2001). Autonomic and brain electrical activity in securely- and insecurely-attached infants of depressed mothers. Infant Behavior and Development, 24, 135-149.

85. Dawson G, Frey K, Panagiotides H, Yamada E, Hessl D, & Osterling J (1999). Infants of depressed mothers exhibit atypical frontal electrical brain activity during interactions with mother and with a familiar, nondepressed adult. Child Development, 70(5), 1058-1066.

86. Dawson G, Frey K, Self JF, Panagiotides H, Hessl D, Yamada E, & Rinaldi J (1999). Frontal brain electrical activation in infants of depressed mothers and nondepressed mothers: Relations to variations in infant behavior. Development and Psychopathology, 11, 589-605.

87. Dawson G, Frey K, Panagiotides H, Osterling J, & Hessl D (1997). Infants of depressed mothers exhibit atypical frontal brain activity: A replication and extension of previous findings. Journal of Child Psychology and Psychiatry, 38(2), 179-186.

88. Dawson G, Hessl D, & Frey K (1994). Social influences on early-developing biological and behavioral systems related to risk for affective disorder. Special Issue: Neural Plasticity,


Sensitive Periods, and Psychopathology. Development and Psychopathology, 6(4), 759-779.

BOOK CHAPTERS

1. Leigh MJ, Hagerman RJ, & Hessl D (2012). Fragile X syndrome. In RL Hansen and SJ Rogers

(Eds.) Neurodevelopmental Disorders and Their Treatment. Washington, DC: American Psychiatric Publishing.

2. Schneider A & Hessl D (2011). Fragile X syndrome. In F. Volkmar (Ed.). Encyclopedia of Autism Spectrum Disorders. Springer: New York, NY.

3. Chiu S, Hessl D, Day J, & Hagerman RJ (2010). Genetic correlates of psychiatric comorbidity: Fragile X syndrome. In M. Bax and C. Gillberg (Eds.). Co-Morbidities in Developmental Disorders. Mac Keith Press: London.

4. Schneider A & Hessl D (2011). Fragile X Syndrome: Life-Course and Strategies for Intervention. In P. Howlin, T. Charman & M. Ghaziuddin (Eds.). SAGE Handbook of Developmental Disorders. Sage Publications Ltd: London.

5. Hessl D, Green C, Aguilar D, Cordeiro L, McCormick C & Yuhas J (2009). Developmental Disability and Fragile X Syndrome: Clinical Overview. In: L.R. Squire (Ed.) Encyclopedia of Neuroscience, volume 3, pp. 487-494. Oxford: Academic Press.

6. Dawson G & Hessl D (1996). Ethical dilemmas in the assessment of maternal depression. In K. Hoagwood, P. Jensen, & C. Fisher (Eds.), Ethical Issues in Mental Health Research with Children and Adolescents. Lawrence Erlbaum Associates: New Jersey.

NON PEER REVIEWED PUBLICATIONS

1. Hessl D, Tassone F, Cordeiro L, Koldewyn K, McCormick C, Green C, Yuhas J, Adams J, & Hagerman RJ (2006). Aggression and self-injurious behavior in boys and young men with fragile X syndrome. National Fragile X Foundation Quarterly.

2. Hessl D, Dyer-Friedman J, Glaser B, Erba H, & Reiss AL (2002). Genes, schools and family: What influences cognitive and behavioral outcome in children with fragile X syndrome? National Fragile X Foundation Quarterly, Spring Edition.

IN PREPARATION/UNDER REVIEW

PRESENTATIONS, ABSTRACTS, AND POSTERS

1. Wadell, P. M., Abucayan, F., Mulgaonkar, A., & Hessl, D. (2014). Social Gaze in Fragile X

Syndrome and Autism. Poster session presented at: AACAP’s 61st annual meeting; October 20-25; San Diego, CA.

2. Hessl D (2014). Cognitive outcome measures in fragile X syndrome: Limitations, solutions and future plans. Gordon Research Conference on Fragile X Syndrome and Autism-Related Conditions. June 1-6, Mount Snow, Vermont.

3. Wang JY, Hessl D, Schneider A, Tassone F, Hagerman RJ, & Rivera SM (2013). Influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles.


Presented at the 1st International Conference on the FMR1 Premutation: Basic Mechanisms and Clinical Involvement. June 23-26, Perugia, Italy.

4. Schneider A, Muzar Z, Summers S, Tassone F, Seritan A, Rivera SM, Grigsby J, Hessl D, & Hagerman RJ (2013). Female characteristics of fragile X-associated tremor/ataxia syndrome. Presented at the 1st International Conference on the FMR1 Premutation: Basic Mechanisms and Clinical Involvement. June 23-26, Perugia, Italy.

5. Schneider A, Gaines A, Seritan A, Tassone F, Rivera SM, Hagerman RJ, & Hessl D (2013). A specific psychiatric profile for female carriers of the FMR1 premutation. Presented at the 1st International Conference on the FMR1 Premutation: Basic Mechanisms and Clinical Involvement. June 23-26, Perugia, Italy.

6. Basuta K, Lozano R, Schneider A, Hessl D, Hagerman RJ, & Tassone F (2013). Molecular and behavior variability in a family with FMR1 related disorders, including two compound heterozygous females. Presented at the 1st International Conference on the FMR1 Premutation: Basic Mechanisms and Clinical Involvement. June 23-26, Perugia, Italy.

7. Schneider A, Johnston C, Tassone F, Sansone S, Abucayan F, Narcisa V, Hagerman PJ, Hagerman RJ, Rivera SM, & Hessl D (2012). Social cognition and broad autism phenotype in men with the fragile X premutation. Journal of Intellectual Disability Research 56(1): 925. Presented at the 15th Society for the Study of Behavioral Phenotypes International Research Symposium, Leuven, Belgium.

8. Mulgaonkar A, Sansone S, Schneider A, Chavez, A, Abucayan F, Tassone F, Hagerman RJ, & Hessl D (2012). Cortisol and stress in fragile X premutation carriers. Poster presented at the 13th International Fragile X Conference, Miami, FL.

9. Johnston C, Schneider A, Tassone F, Sansone S, Rivera S, Hagerman RJ, & Hessl D (2012). Memory functioning in male premutation carriers without FXTAS. Presented at the 13th International Fragile X Conference, Miami, FL.

10. Au J, Schneider A, Berkowitz-Sutherland L, Hessl D, Hagerman RJ, & Schweitzer J (2012). Evaluation of Cogmed working memory training in fragile X. Presented at the 13th International Fragile X Conference, Miami, FL.

11. Hessl D, Abucayan F, Mulgaonkar A, Schneider A, Sansone S, Chechi T, Leigh MJ, & Hagerman RJ (2012). Effect of minocycline treatment on attention and social gaze processing in children with fragile X syndrome. Presented at the 13th International Fragile X Conference, Miami, FL.

12. Schneider A, Adams P, Nanakul R, Chechi T, Hagerman R, Olichney JM, & Hessl D (2012). Differences in cortical hyperexcitability in fragile X syndrome. Presented at the 13th International Fragile X Conference, Miami, FL.

13. Schneider A, Adams P, Nanakul R, Chechi T, Leigh MJ, Hagerman RJ, Olichney JM, & Hessl D (2012). Electrocortical changes during a double blind, placebo controlled trial of minocycline in children with fragile X syndrome. Presented at the 13th International Fragile X Conference, Miami, FL.

14. Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E, Lachiewicz A, Brown EC, & Hessl D (2012). Psychometric evaluation of the Aberrant Behavior Checklist factor structure in fragile X syndrome: A multi-site collaborative study. 13th International Fragile X Conference, Miami, FL.

15. Posussa J, Mulgaonkar A, Schneider A, & Hessl D (2012). Eye tracking as a potential screening tool for FXTAS in premutation carriers. 13th International Fragile X Conference, Miami, FL.


16. Hessl D (2012). Proving efficacy in fragile X clinical trials: Measure options, present and future. Invited presentation at Fragile X and Autism-Related Disorders: From Basic Neuroscience to Improved Clinical Care. Gordon Research Conference, Stonehill College, Easton, MA.

17. Hessl D (2011). Insights into autism through fragile X research. Invited presentation at the Autism Working Group of the Stanford Autism Center at Packard Children's Hospital, Stanford, CA

18. Hessl D, Schneider A, Sumekar T, Cheung K, Hagerman PJ, Roid G (2011). Intelligence measurement in X linked intellectual disability: Limitations, solutions, and where do we go from here? 14th Annual Fragile X and X-Linked Intellectual Disability Conference, Berlin Germany.

19. Kim S-Y, Burris J, Bassal F, Tassone F, Hessl D, & Rivera SM (2011). Socio-emotional dysfunction and its relationship with neural correlates of emotional processing in children and adolescents with fragile X syndrome Society for Neuroscience, Washington DC

20. Russo N, Yesinsky J, Hessl D, & Berry-Kravis E (2011). Feasibility, reproducibility, and clinical validity of the Pediatric Anxiety Rating Scale (PARS) in fragile X syndrome. Poster presentation at the Child Neurology Society, Savannah, Georgia

21. Schneider A, Nanakul R, & Hessl D (2010). First Steps into Developing EEG as Medication Outcome Measure for Targeted Treatments in Fragile X. International Conference on Genetics and Neurobiology of Mental Retardation, Biennial Conference of the German Academy of Sciences Leopoldina, National Academy of Sciences, 29th September to 1st October, 2010, Erlangen, Germany, Molecular Syndromology 2010;1:136-157.

22. Hessl D (2010). Clinical and Physiological Phenotypes in Fragile X-Associated Disorders: Examples of Outcome Measure Development. John D Wiley Seminar Series . Waisman Center, University of Wisconsin, Madison, WI

23. Hessl D & Hagerman PJ (2010). FXTAS as a model for understanding neurogenetic disorders. Translational Grand Rounds, Department of Psychiatry and Behavioral Sciences, UC Davis

24. Rivera SW, Wang J, Koldewyn K, Schneider A, Tassone F, Hagerman RJ, Hagerman PJ, Iwahashi C, & Hessl D (2010). Gene-brain-behavior relationships in fragile X premutation carriers: The limbic system. Gatlinburg Conference on Research & Theory in Intellectual & Developmental Disabilities, Annapolis, MD

25. Hessl D (2010). Cognitive testing in children with intellectual disabilities: A new solution to a pervasive problem. 25th Annual Learning and the Brain Conference, San Francisco, CA

26. Wang J, Koldewyn K Hessl D, Selmeczy D, Hagerman RJ, Hagerman PJ, Iwahashi C, Tassone F, Schneider A, & Rivera S (2009). Fragile X mental retardation-1 gene mRNA as a predictor for amygdala volume in fragile X premutation men. Poster presented at Society for Cognitive Neuroscience Annual Meeting, San Francisco, CA

27. Hessl D (2009). What we learn about autism from studying fragile X syndrome. Minds Behind the MIND lecture series. MIND Institute, UC Davis

28. Hessl D (2008). Outcome measures for clinical trials: What do we have now and what do we need? FRAXA Investigators Meeting, University of New Hampshire, Durham

29. Hessl D (2008). Thinking outside the box: New neurophysiological and behavioral tools for clinical research in neurodevelopmental disorders. Presented at the Waisman Center, University of Wisconsin, Madison

30. Hessl D (2008). Psychophysiology of emotion in fragile X and Down syndromes: Similarities, contrasts, and implications for treatment. Presented at the Waisman Center, University of Wisconsin, Madison


31. Farzin F, Rivera SM, Weru J, & Hessl D (2008). Face processing in individuals with fragile X syndrome: An eye-tracking study. Presented at the 11th International Fragile X Conference, St Louis, Missouri

32. Adams PE, Adams JS, Nguyen D, Hessl D, Brunburg JA, Tassone F, Zhang L, DeCarli C, Hagerman PJ, & Hagerman RJ (2008). Psychiatric problems in female fragile X premutation carriers, with involvement of the hippocampus. Presented at the 11th International Fragile X Conference, St Louis, Missouri

33. Chavez A, Schneider A, Green C, Nguyen D, Loesch D, Gould E, & Hessl D (2008). Limitations of the standard IQ score in fragile X syndrome: A proposed solution using an individual deviation score. Presented at the 11th International Fragile X Conference, St Louis, Missouri

34. Hessl D, Schneider A, Cordeiro L, Tassone F, Rivera S, Nguyen D, Gane L, & Hagerman RJ (2008). Genetic and brain correlates of psychiatric and cognitive functioning in men with the fragile X premutation. Presented at the 11th International Fragile X Conference, St Louis, Missouri

35. Schneider, A, Hessl D, Tassone F, Yuhas, J, Le, L, Chavez, A, Gane, L, & Hagerman RJ (2008) Two faces of the fragile-X premutation – clinical correlates of CGG repeat size and methylation Presented at the 11th International Fragile X Conference, St Louis, Missouri

36. Hessl D (2007) Commonalities in psychophysiological dysfunction in fragile X and autism 10th International Meeting of the Society for the Study of Behavioural Phenotypes, Sacramento, CA

37. Rivera, SM, Hessl D, Koldewyn, K, Tassone F, & Hagerman RJ (2007) Brain-based evidence of limbic system dysfunction in fragile X premutation carriers Presented at the 13th International Workshop on Fragile X and X-Linked Mental Retardation, Venice, Italy

38. Hessl D, Tassone F, Campbell, A, Cordeiro, L, Yuhas, J, Ornitz, E, & Hagerman RJ (2007) Prepulse inhibition in fragile X syndrome and FXTAS Presented at the 13th International Workshop on Fragile X and X-Linked Mental Retardation, Venice, Italy

39. Hagerman RJ, Soontarapornchai, K, Maselli, R, Fenton-Farell, G, Tassone F, Hessl D, & Hagerman PJ (2007) Characterization of the neuropathy in the fragile X-associated tremor/ataxia syndrome (FXTAS) Presented at the 13th International Workshop on Fragile X and X-Linked Mental Retardation, Venice, Italy

40. Hessl D, Rivera, S, Koldewyn, K, Cordeiro, L, Adams, J, Tassone F, Hagerman PJ, & Hagerman RJ (2006) Amygdala dysfunction in men with the fragile X premutation Presented at the 11th Annual Meeting of the Society for the Study of Behavioural Phenotypes, Royal College of Surgeons, Dublin, Ireland Journal of Intellectual Disabilities Research, 50, 787

41. Tartaglia, N, Hansen, R, Reynolds, A, Hessl D, Bacalman, S, Goodlin-Jones, B, Deprey, L, & Hagerman RJ (2006) Attention deficit hyperactivity disorder and autism spectrum disorders in males with XXY, XYY and XXYY syndromes Presented at the 11th Annual Meeting of the Society for the Study of Behavioural Phenotypes, Royal College of Surgeons, Dublin, Ireland Journal of Intellectual Disabilities Research, 50, 787

42. Hagerman RJ, Adams, J, Adams, P, Nguyen, D, Hessl D, Tassone F, & Hagerman PJ (2006) FXTAS: A comparison of male vs female involvement Presented at the 11th Annual Meeting of the Society for the Study of Behavioural Phenotypes, Royal College of Surgeons, Dublin, Ireland Journal of Intellectual Disabilities Research, 50, 789


43. Hessl D & Roberts, J (2006) Psychophysiological studies and biophysical outcomes Presented at the National Institute of Child Health and Human Development Fragile X Meeting, Atlanta, GA

44. Hessl D, Cordeiro, L, Koldewyn, K, Tassone F, Cohen, S, Green, C, McCormick, C, & Hagerman RJ (2006) Aggressive behavior in fragile X syndrome: Genetic, physiological, and environmental factors Presented at the 10th International Fragile X Conference, Atlanta, GA

45. Hessl D, Cordeiro, L, Tassone F, & Hagerman RJ (2006) Evidence of reduced psychophysiological responses to social-emotional stimuli in adult males with the fragile X premutation Presented at the 10th International Fragile X Conference, Atlanta, GA

46. Rivera, S, Koldewyn, K, Tassone F, Hagerman RJ, & Hessl D (2006) fMRI evidence of amygdala dysfunction in men with the fragile X permutation Presented at the 10th International Fragile X Conference, Atlanta, GA

47. Koldewyn, K, Rivera, S, Hessl D, Tassone F, & Hagerman RJ (2006) Evidence of hippocampal dysfunction in males with the fragile X premutation Presented at the 10th International Fragile X Conference, Atlanta, GA

48. Tartaglia, N, Bacalman, S, Hessl D, Goodlin-Jones, B, Deprey, L, Ono, M, Tsang, S, Davis, S, Reynolds, A, Wegelin, J, Hansen, R, & Hagerman, R (2006) Autism spectrum disorder in males with sex chromosome aneuploidy Poster presented at the International Meeting of Autism Researchers (IMFAR) meeting Montreal, Canada

49. Chiu, S, Wegelin, J, Blank, J, Jenkins, M, Day, J, Hessl D, Tassone F, & Hagerman, R (2006) Early acceleration of head circumference in children with fragile X syndrome and autism Poster presented at the International Meeting of Autism Researchers (IMFAR) meeting Montreal, Canada

50. Hessl D (2006) Psychopathology associated with the fragile X full mutation and premutation Centers for Disease Control Focused Advisory Group on Psychiatric and Behavioral Issues in Fragile X Syndrome Sacramento, CA

51. Koldewyn, K, Hessl D, Tassone F, Cordeiro, L, Hagerman RJ & Rivera, S (2006) Psychophysiological and fMRI evidence of amygdala dysfunction in men with the fragile X premutation Poster presented at the Annual Cognitive Neuroscience Meeting, San Francisco, CA

52. Tartaglia, N, Bacalman, S, Goodlin-Jones, B, Deprey, L, Hessl D, Ono, M, Tsang, S, Davis, S, Reynolds, A, Hansen, R, Hagerman, R (2006) Autism spectrum disorders in males with sex chromosome aneuploidy Poster presented at the International Meeting for Autism Research, Montreal, Canada

53. Hessl D (2006) Autism: Best practices in clinical assessment Presented at the 5th Annual Developmental Disabilities Conference, University of California, San Francisco, CA

54. Hessl D (2006) Identification and treatment of anxiety and depression in trisomy X and XYY syndromes Presented at the First National Conference on Trisomy X and XYY Sacramento, CA

55. Koldewyn, K, Rivera, S, Hessl D, Tassone F, & Hagerman RJ (2005) Evidence of hippocampal dysfunction in males with the fragile X premutation Poster presented at the 35th Annual Society for Neuroscience Meeting, Washington, DC

56. Hessl D, Tassone F, Loesch, DZ, Berry-Kravis E, Leehey, M, Gane LW, Barbato, I, Rice, C, Gould, E, Hall, DA, Grigsby, J, Wegelin, JA, Harris, S, Lewin, F, Weinberg D, Hagerman PJ, & Hagerman RJ (2005) Abnormal elevation of FMR1 mRNA is associated with


psychological symptoms in individuals with the fragile X premutation Presented at the 12th International Workshop on Fragile X and X-Linked Mental Retardation, Williamsburg, VA

57. Hessl D (2005) Hyperarousal, stress, and aggression in fragile X syndrome Presented at National Fragile X Awareness Day, Sacramento, CA

58. Zhang, L, Coffey, S, Aguis, M, Adams, J, Nowicki, S, Tartaglia, N, Ono, M, Cook, K, Yuhas, J, Barbato, I, Harris, S, Apperson, M, Gane, L, Tassone F, Hessl D, Cordeiro, L, Brunberg, J, Hall, D, Leehey, M, Hagerman, P, Hagerman, R (2005) Clinical and MR abnormalities in females carrying the FMR1 premutation Neurology, 64(6), A92-A93 Presented at the 57th Annual Meeting of the American Academy of Neurology, Miami Beach, Florida

59. Hessl D (2005) Stress and anxiety in autism and fragile X syndrome Presented at the 1st International Conference and Clinic on Autism and Fragile X Syndrome, Dubai, United Arab Emirates

60. Hessl D, Pinter, J, Deprey, L, Chiu, S, Winn, C & Hagerman, R (2005) Autism in a young man with 8p23 deletion syndrome: Expanding the phenotype? Presented at the 66th Canadian Psychological Association Annual Convention, Montreal, Canada

61. Chiu, S, Hessl D, Day, J, Copeland, L, Maddock, R, Hagerman, R & Hendren R (2004) Pediatric psychosis in fragile X syndrome Presented at the 51st Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Washington DC

62. Hessl D, Cohen, S, Perry, H, Tassone F, & Hagerman RJ (2004) Potentiated startle and galvanic skin responses to social and emotional stimuli in children with fragile X: A pilot study Presented at the Ninth International Fragile X Conference, Washington, DC

63. Hessl D, Tassone F, Perry, H, Cohen, S, Yehuda, R, Makotkine, I, Hagerman PJ, & Hagerman RJ (2004) Glucocorticoid receptor (GR) mRNA and lymphocyte GR concentration in males with fragile X syndrome Presented at the Ninth International Fragile X Conference, Washington, DC

64. Cordeiro, L, Hessl D, Tassone F, Gould, E, Loesch, D, Barbato, I, Perry, H, Gane LW, Hagerman PJ, & Hagerman RJ (2004) Genotype-phenotype relationships in children with fragile X: Association between FMR1 protein expression and behavior Presented at the Ninth International Fragile X Conference, Washington, DC

65. Hessl D, Cohen, S, Gane, L, Jardini, T, Tassone F, Hagerman, P, & Hagerman RJ Structural neuroimaging and molecular correlates of psychopathology in adult males with the FMR1 premutation (2003) American Journal of Medical Genetics, 73(5), 266 Proceedings of the 53rd Annual Meeting of the American Society of Human Genetics, Los Angeles

66. Cohen, S, Jaquemont, S, Hessl D, Jardini, T, Harris, S, Tong-Turnbeaugh, R, Jagust, W, Rivera, S, Gane, L, Tassone F, Hagerman, P, & Hagerman, R (2003) Neuroimaging correlates of fragile X-associated tremor/ataxia syndrome (FXTAS) Presented at the 11th International Workshop on Fragile X Syndrome and X-Linked Mental Retardation, Paphos, Cyprus

67. Hagerman, R, Zhang, L, Brunberg, J, Hessl D, Jacquemont, S, Tassone F, Harris, S, Jardini, T, & Hagerman PJ (2003) Two female cases of the fragile X premutation tremor/ataxia syndrome: Cognitive, molecular, and radiological studies Presented at the 11th International Workshop on Fragile X Syndrome and X-Linked Mental Retardation, Paphos, Cyprus

68. Hessl D (2003) Psychophysiology of Emotion in Neurodevelopmental Disorders Presented at Neurodevelopmental Disorders: From Research to Practice, Sacramento, CA

69. Hessl D (2003) Genetic, Environmental, and Physiological Contributions to Behavior in Fragile X Syndrome Presented at La Trobe University, Bandoora, Australia


70. Hagerman, R, Hessl D, Hess, L, Lemons, K, & Stackhouse, T (2002) Panel on hyperarousal Presented at Neurodevelopmental Disorders: From Research to Practice, Sacramento, CA

71. Hessl D (2002) Is it all genes? The impact of environmental and neurohormonal variables on outcome in children with fragile X Presented at the Eighth International Fragile X Conference, Chicago, IL

72. Dyer-Friedman, J., Hessl D, Glaser, B., Kosaraju, A., & Reiss, A. (2001). The Special Curriculum Opportunity Rating Scale (SCORS): A measure of educational and therapeutic effectiveness. Presented at the 14th Annual Research Conference, A System of Care for Children’s Mental Health: Expanding the Research Base, Tampa, FL.

73. Hessl D, Reiss, A., & Merin, N. (2000). Magnetic resonance imaging during processing of gaze in fragile X syndrome. Presented at the Seventh International Fragile X Conference, Los Angeles, CA, July 2000.

74. Hessl D (2000). Assessment of stress hormone (cortisol) levels in children with fragile X syndrome. Presented at the Seventh International Fragile X Conference, Los Angeles, CA.

75. Reiss, A., Dyer-Friedman, J., Hessl D, & Glaser, B. (2000). Factors predicting outcome in fragile X syndrome. Presented at the Seventh International Fragile X Conference, Los Angeles, CA.

76. Taylor, A., Patterson, K., Dyer, P., Linden, M., Murphy, J., Tassone F, Blasey, C., Hessl D, Reiss, A., Butler, E., Loesch, D. & Hagerman R. (2000). FMRP expression and clinical correlates in mosaic males, males with a partially methylated full mutation, and females with a full mutation. Presented at the Seventh International Fragile X Conference, Los Angeles, CA.

77. Hessl D & Davidson, J. (1999). A prospective study of stress and health in young children: Is immune reactivity a source of resilience? Poster presented at the Society for Research in Child Development Meeting, Albuquerque, NM.

78. Dawson, G., Frey, K., Panagiotides, H., Self, J., Hessl D, & Yamada, E. (1997). Atypical frontal brain activity in infants of depressed mothers: The role of maternal behavior. Presented at the Meeting of the Society for Research in Child Development as part of a symposium on “The Impact of Trauma and Adversity on Behavioral and Physiological Development: Clarifying the Issues.”

79. Hessl D, Dawson, G., Frey, K., Panagiotides, H., Self, J., Yamada, E., & Osterling, J. (1998) A longitudinal study of children of depressed mothers: Psychobiological findings related to stress. In D.M. Hann, L.C. Huffman, K.K. Lederhendler, and D. Meinecke (Eds.) Advancing research on developmental plasticity: Integrating the behavioral science and the neuroscience of mental health. National Institute of Mental Health: Bethesda, MD.

80. Dawson, G., Frey, K., Hessl D, Panagiotides, H., & Self, J (1995). Infants of depressed mothers exhibit atypical frontal brain activity: A replication of previous findings. Presented at the Meeting of the Society for Research in Child Development, Indianapolis, IN.

81. Hessl D (1998). Fathering young children: Maternal depression, paternal mental health, and marital adjustment as determinants of involvement and parenting. Dissertation Abstracts International: Section B: The Sciences & Engineering, 58(8-B), 4450.

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CURRICULUM VITAE David Randal Hessl, Ph.D. · 2015-02-18 · David R. Hessl, PhD, 2 2006 – 2008 . Assistant Professor of Clinical Psychiatry. Department of Psychiatry and Behavioral