CURRICULUM VITAE Full Name Francesco Misiti Date of Birth 15th January 1968 Place of Birth Rome-ITA Citizenship Italian E-mail f.misiti@unicas.it Part I – Education University graduation 1993 University of Rome - Sapienza Master’s degree in Biological sciences

110/110 cum laude

Post-graduate studies 1995-98

Catholic University- School of Medicine-Rome

Research fellow

PhD 2001 University of Sassari PhD course in Comparative Biochemistry

Pre-doctorate training 2000 Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, USA

Visiting Researcher

Part II – Appointments 1991 1992 University of Rome – Sapienza, Plant

Biochemistry Inst. Student

1993 1993 Agricultural Research Council - Research Centre for the Soil-Plant System -Rome

Attending researcher

4/1995 8/1995 Catholic University- School of Medicine- Institute of Biochemistry and Clinical Biochemistry-Rome

Attending researcher

9/1995 1998 Catholic University- School of Medicine- Institute of Biochemistry and Clinical Biochemistry-Rome

Research fellow

1998 2000 University of Sassari PhD student

1999 3/2005 Catholic University- School of Medicine- Institute of Biochemistry and Clinical Biochemistry-Rome

University Researcher

3/2000 10/2000 Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, USA

Visiting researcher

3/2005 Present University of Cassino and Southern Lazio- Department of Health and Motor Sciences

Associate Professor

2010 2012 University of Rome- SAPIENZA- School of Medicine in collaboration with University of Cassino

Head of Bachelor in Physiotherapy

2011 2012 University of Cassino and Southern Lazio- Department of Health and Motor Sciences

Vice-Director of Department

2012 2018 University of Cassino and Southern Lazio- Department of Health and Motor Sciences

Head of Bachelor and Master programs in Exercise and Sport Sciences

2012 present University of Cassino and Southern Lazio

Full Professor in Biochemistry

2018 present University of Cassino and Southern Lazio

Delegate of the Chancellor for orientation

Part III – Teaching experience Main teaching topics are: general biochemistry, organization and communication in cells, cell metabolism and hormone signaling, clinical biochemistry. Cassino and Southern Lazio University-Faculty of Sport Sciences

Biochemistry- Sport Sciences Bachelor Degree

Cassino and Southern Lazio University-Faculty of Sport Sciences

Biochemistry- Sport Sciences Master Degree

Part IV - - Society memberships, Awards and others Year Title 1999-present

Italian Society of Biochemistry and Molecular Biology (SIBBM)

1995-2009

Registered Biologist

Associate Editor for “Frontiers in Aging Neuroscience" e Review Editor for"Red Blood Cell Physiology"

Part V - Funding Information Main projects 2018-2020

project nr. 590400 Athletic migration: Dual Career and qualification in sports (AMID)(Main Applicant: University of Salzburg, ), (University of Cassino and SL partner

EU-Erasmus Sport plus

2010 Characterization of gene expression

profile of microRNAs and circulating tumor cells: Correlation with tumor histology and grade of disease - PI

Regione Lazio-CRUL (3 years)

Part VI – Research Activities Research main interests are: i) the structure and function of hemoproteins, mainly hemoglobin, ii) study of erythrocyte signaling pathways involved in the regulation of cell metabolism, iii) new analytical methods of biochemical interest. Presently he focused his main research interests in neurodegenerative pathologies, initiating studies of a new model based on the red blood cell (RBC), to investigate the role of vascular alterations in the mechanisms responsible for Alzheimer’s disease. Based on the results obtained, a new AD-pathogenesis hypothesis has been suggested, that is, the RBC hypothesis of AD, which would help advance the current understanding of the AD pathogenesis. Main technical skills: biochemical techniques, purify and characterize proteins, chromatography, electrophoresis, enzymology. – Selected Publication (2016-2020)

1) Carelli-Alinovi, C., Dinarelli, S., Girasole, M., Misiti, F. Vascular dysfunction-associated with Alzheimer's disease (2016) Clinical Hemorheology and Microcirculation, 64 (4), pp. 679-687. 2) Carelli-Alinovi, C., Ficarra, S., Russo, A.M., Giunta, E., Barreca, D., Galtieri, A., Misiti, F., Tellone, E. Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against β-amyloid-induced alterations in red blood cells (2016) Biochimie, 121, pp. 52-59. 3) Carelli-Alinovi, C., Misiti, F. Methionine 35 sulphoxide reduces toxicity of Aβ in red blood cell (2017) European Journal of Clinical Investigation, 47 (4), pp. 314-321. 4) Carelli-Alinovi C, Misiti F. Erythrocytes as Potential Link between Diabetes and Alzheimer's Disease. (2017) Front Aging Neurosci. Aug 25; 9:276. 5) Misiti, F; Carelli-Alinovi, Cristiana; Dinarelli, Simone; Girasole, Marco. Role of Red blood cells in vascular dysfunction-associated with alzheimer's disease.pp.1890-1890. In Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases.13th International Conference AD/PD Vienna, Austria, March 29 to April 2, 2017: Abstracts. In Neurodegenerative Diseases – vol. 17 Suppl 1 (1) 6) Misiti, F. Exercise vs. high altitude therapy

(2018) Journal of Sport and Health Science, vol. 7, p. 125 7) Carelli-Alinovi, Cristiana, Dinarelli, Simone, Sampaolese, Beatrice, Misiti, F, Girasole, Marco Morphological changes induced in erythrocyte by amyloid beta peptide and glucose depletion: A combined atomic force microscopy and biochemical study. (2018). Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):236-244.

8) Dinarelli S, Girasole M, Misiti F. Amyloid ß peptide affects erythrocyte morphology: Role of intracellular signaling pathways. Clin Hemorheol Microcirc. 2019;71(4):437-449.