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CURRICULUM VITAE SAUL SCHAEFER, M.D.
DATE OF BIRTH CITIZENSHIP United States SOCIAL SECURITY NUMBER
ADDRESS Home:
Offices: University of California Division of Cardiovascular Medicine
TB 172 Bioletti Way Davis, CA 95616 Fax 530-752-3264
e-mail [email protected]
Sacramento VA Medical Center Cardiology Section 111-C 10565 Hospital Way Mather, CA 95655 916 843-7138 e-mail [email protected]
EDUCATION 1964 - 1968 Bachelor of Engineering (Mechanical)
The Cooper Union, New York, NY.
1968 - 1969 Graduate Studies: Mechanical Engineering, University of Southern California, Los Angeles, CA.
1969 - 1970 Graduate Studies: Pepperdine University, Los Angeles, CA.
1970 - 1976 Graduate Studies: Physiology and Bioengineering,
University of California, Los Angeles, CA.
1977 - 1981 Doctor of Medicine, University of California, Davis, CA. RESIDENCY
1981 - 1984 Resident, Straight Internal Medicine, University of California, San Francisco, CA.
FELLOWSHIP
1984 - 1987 Fellow, Cardiology, University of Texas Southwestern Medical Center, Dallas, TX.
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OTHER 1968 - 1970 Engineer, Navigation system design and analysis,
Hughes Aircraft Co., Los Angeles, CA.
1976 - 1977 Research Associate, Biophysics Section, Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA.
1993 Consultant, American Heart Association, Drug Evaluations
LICENSURE
Licensed to practice medicine in the State of California (# G49459)
BOARD CERTIFICATION 1970 California State Teaching Credential 1976 Professional Certificate in Bioengineering, UCLA 1982 National Board of Medical Examiners 1984 American Board of Internal Medicine (Internal Medicine) 1987 American Board of Internal Medicine (Cardiovascular Disease)
HONORS
1964 NY State Regents Scholarship 1967 Pi Tau Sigma (Mechanical Engineering) 1968 Tau Beta Pi (Engineering) 1980 Alpha Omega Alpha 1981 Mosby Scholarship Award 1981 Award for Excellence in Diagnostic Radiology 1989 Fellow, American College of Cardiology 1994 Best Doctors in America 1994 Who's Who in the West 1996 Best Doctors in America 1996 The Best 2,000 Doctors 1997 - 1999 Editorial Board, Journal of the American College of Cardiology 1997 Fellow, American Heart Association, Council on Circulation 1998 Best Doctors in America 1998 Who’s Who in the West 1998 VA Merit Review 1999 UCDHS Grant 2001-2012 Best Doctors in America 2002 Faculty Research Award, UC Davis School of Medicine 2009 UC Davis School of Medicine Alumni Association Distinguished Alumnus Award
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ACADEMIC AND TEACHING APPOINTMENTS 1970 - 1976 Teacher, secondary school level,
Los Angeles Unified School District, Los Angeles, CA.
1987 - 1990 Assistant Director, Echocardiography Laboratory, VA Medical Center, San Francisco, CA.
1987 - 1991 Assistant Professor of Medicine and Radiology in Residence,
University of California, San Francisco, CA.
1990 - 1991 Director, Interventional Cardiology, VA Medical Center, San Francisco, CA.
1991 - 1994 Director, Interventional Cardiology, University of California, Davis, Medical Center
University of California, Davis, CA.
1991 - 1997 Associate Professor of Medicine, University of California, Davis, CA.
1996 - present Chief, Cardiology
Department of Veterans Affairs Northern California Health Care System
1997 - 1998 Associate Chief, Division of Cardiovascular Medicine
Director of Clinical Cardiology, University of California, Davis, Medical Center Professor of Medicine, University of California, Davis, CA.
1998 - 2000 Acting Chief, Division of Cardiovascular Medicine University of California, Davis, Medical Center.
1998-2005 Director, Executive Physical Program University of California, Davis, Medical Center 2001-2002 Acting Associate Chief of Staff, Research and Development
Department of Veterans Affairs Northern California Health Care System
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UNIVERSITY AND PUBLIC SERVICE University of California
1993-present Member, Molecular and Cellular Physiology Graduate Group 1995-1998 Member, Human Subjects Review Committee 1997-1998 CPB Billing Work Group 2001-2003 Faculty Representative, UC Health System Retirement Task Force 2002-2003 Chair, Recruitment Committee, Molecular and Cellular Physiology Graduate Group 2004-2013 Member, Committee on Faculty Welfare, UC Davis 2009-2011 Chair, Committee on Faculty Welfare, UC Davis 2009-2010 Board of Directors, Davis Faculty Association Committee 2011-present Divisional Representative, UC Davis Assembly Academic Senate 2011-present Executive Committee and Chair, Support Committee MCIP Graduate Group 2012-2013 Member, University of California Health Care Benefits Work Group 2014-2015 Member, Task Force on Faculty Salary Equity 2015 – present Member, Task Force on UC Health Care Benefits
School of Medicine 1992-1993 Chair, UC Davis Heart Center Task Force on Referrals 1993-1994 Member, Strategic Planning Committee - Research Priorities Workgroup 1994, 1998 Chair and Member, Faculty promotion Ad-Hoc Committee 1996-2000 Member, UC Davis Heart Center Cardiac Services Performance Improvement
Committee 1996-1998 Chair, Subcommittee on Pre-Procedure Evaluation, Interventional Cardiology
QUEST Team 1996-1997 Member, Faculty Merit/Promotion Ad-Hoc Committee 1997-1998 Member, Predoctoral Research Fellowship Committee 1999-present Chair, Medical Student Research Fellowship Committee 1998-2003 Member, Research Affairs Committee 1998 Member, CAP Ad Hoc Committee 1999-2000 Member, Pharmacy and Therapeutics Committee 2003 Member, Scholarly Project Task Force Committee 2003 Member, Search Committee, Assistant Dean Clinical Research 2012 Chair, LCME Implementation Team Task Force – Clinical Skills 2004-present Chair, Scholarly Project Executive Committee 2009-present Co-Director, UC Davis NIH T32 program 2011-present Director, Medical Student Research, UC Davis School of Medicine 2013-present Director, Physician Scientist Training Program, UC Davis School of Medicine
Department of Internal Medicine
1993 Member, Search Committee for Chief, Gastroenterology 1993-1995 Member, Department of Internal Medicine Intern Selection Committee 1993-1994 Member, Resident Selection Committee 1996-2000 Member, Internal Medicine Quality Improvement Committee
Division of Cardiovascular Medicine
1993-1994 Member, Fellowship Selection Committee 1993-1994 Member, Faculty Search Committee 1995-present Co-Coordinator, Division of Cardiovascular Medicine Clinical Research Conference 1995-present Co-Director, CME Course “Cardiology for the Primary Care Practitioner” 1995-1998 Chair, Division of Cardiovascular Medicine CQI 1998-2001 Chair, Division of Cardiovascular Medicine Research Seminar
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Ad-Hoc Committees 1993 Study Section Reviewer, National Institute of Aging 2002 Study Section Reviewer, National Institute of Health 1995 - 2010 Reviewer, Veteran’s Administration Merit Review 2009 - 2015 Study Section Reviewer, NIH Clinical Trials Review Committee
Other
1992-1996 Grant Reviewer, American Heart Association, California Affiliate 1992-1996 American Heart Association, Cardiovascular Research Peer Review Subcommittee 2003-present American Heart Association, Cardiovascular Research Peer Review Subcommittee 1993 Chair, Cardiovascular Section, American Federation of Clinical Research, Western
Regional Meeting 1993 Consultant on Drug Education, American Medical Association 1993-1994 Grant-in-Aid Review Committee, American Heart Association, California Affiliate,
Postdoctoral Fellowship Review Committee 1999 Co-Chair and Moderator, American Heart Association Scientific Session, Atlanta,
GA, “Magnetic Resonance Imaging of Myocardial Perfusion” 1999 Session Chair, American Heart Association Scientific Session, Atlanta, GA,
“Arrhythmias and Antiarrhythmic Drug Therapy-Basic and Clinical” 1999 Abstract Reviewer, American Heart Association Scientific Sessions 2000 Co-Chair and Moderator, American Heart Association Scientific Session, Anaheim
CA, "Cardiovascular MR: Experimental Frontiers" 2008 Chair, American Heart Association, Western States Affiliate, Young Investigators
Forum PEER REVIEW FOR JOURNALS Circulation Journal of American College of Cardiology Cardiovascular Research Journal of Molecular and Cellular Cardiology American Journal of Physiology American Journal of Cardiology Journal of Applied Physiology Catheterization & Cardiovascular Diagnosis Magnetic Resonance in Medicine The Journal of the Society for Academic Emergency Medicine EDITORIAL BOARD 1999-2001 Journal of American College of Cardiology 2001-2003 Society of Cardiovascular Magnetic Resonance 2005-2012 Preventive Cardiology (Associate Editor) 2009-present Metabolic Syndrome and Related Disorders
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INVESTIGATOR’S FUNDING 1987- National Institutes of Health NMR Assessment of Regional Myocardial Perfusion $ 329,500 1992 Principal Investigator 1988- American Heart Association Metabolic Responses of Regionally Ischemic $ 100,000 1990 California Affiliate Myocardium
Principal Investigator 1989- National Institutes of Health High Energy Phosphate and Carbohydrate $ 206,440 1992 Program Project Grant Metabolism in LVH
Collaborator (Barry Massie, PI)
1990- American Heart Association Myocardial Metabolism During Sustained Partial $ 100,000 1992 California Affiliate Stenosis
Principal Investigator 1992- UC Davis Medical Center The Role of Tissue O2 and Redox State in Ischemic $ 50,000 1993 Research Fund Award and Post-Ischemic Myocardium
Collaborator (Thomas Jue, PI)
1993- UC Davis Mechanisms of Adaptation During Sustained $ 5,000 1994 Deans Research Award Myocardial Ischemia, Principal Investigator
1993- American Heart Association Metabolic Adaptation of Acute Hibernation $ 100,000 1995 California Affiliate
Principal Investigator 1993- National Institutes of Health MR Imaging and Computer Reconstruction of $ 348,816 1997 Collaborator Flow Patterns
(Michael Buonocore, PI) 1994- UC Davis Ionic Determinants of Ischemic Injury to the Heart $ 1,500 1995 Faculty Research Grant
Principal Investigator 1994- American Diabetes Association Metabolic Mechanisms of Diabetic Cardiomyopathy $ 225,000 1997 Collaborator
(Ravichandran Ramasamy, PI) 1995- UC Davis Ion Regulation During Low Flow Ischemia $ 3,000 1996 Faculty Research Grant
Principal Investigator 1995- UC Davis School of Medicine’s Mechanisms of the “Warm-up Phenomenon” in $ 7,250 1996 Dean’s Research Fund Patients with Angina: the Role of the KATP Channel
Principal Investigator 1995- Hoechst Roussell Pharm. HOE 642 in Hibernating Myocardium $ 107,136 1996 Principal Investigator
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1995 Pfizer Labs, Inc. Anti-ischemic Effects of Aldose Reductase Inhibition $ 35,000 Collaborator in Diabetic and Nondiabetic Isolated Perfused Rat (Ravichandran Ramasamy, PI) Hearts
1996- American Heart Association Ion Regulation in Hibernating Myocardium $ 120,000 1998 National Grant-In-Aid
Principal Investigator 1996- UC Davis Medical Center Ischemic Tolerance in Diabetic Rats $ 50,000 1997 Research Fund
Collaborator (Ravichandran Ramasamy, PI)
1996- Juvenile Diabetes Foundation Nitric Oxide Modulates Ischemic Injury in Diabetic $ 100,000 1998 Collaborator Hearts
(Ravichandran Ramasamy, PI) 1997- UC Davis School of Medicine Role of Norepinephrine in the Protective Effect $ 9,000 1998 Dean's Research Grant of Fasting
Principal Investigator 1997- UC Davis NMR Facility Cytosolic Redox State and Myocardial $ 1,500 1998 Research Grant Metabolism
Principal Investigator 1997- Veteran's Administration Alterations in Ion Transport During Preconditioning $ 450,000 2002 Merit Review Grant
Principal Investigator 1997 Pfizer Labs, Inc. A Randomized, Double-Blind Trial of the Anti-Ischemic $ 40,000
Principal Investigator Effect of Zopolrestat in Patients with Ischemic Heart Disease (Multi-Center Trial Originated at UCD)
1997 - Hoechst Marion Rousell Effects of Cariporide in patients at risk for myocardial $ 40,000
Principal Investigator infarction. 1999 - UC Davis Health A Catalytic Redox Sensor on the Cardiac Ryanodine $ 100,000
Systems Grant Receptor Principal Investigator
2001- UC Children’s Miracle Network NADH Modulates Contractile Dysfunction in Juvenile $ 34,960 2003 Research Award Diabetes
Principal Investigator
2002- American Heart Association Regulation of Mitochondrial Calcium during Ischemia $ 210,000 2005 National Grant-in-Aid
Principal Investigator
2002- Philip Morris External Research Smoke induced alterations in mitochondrial calcium $415,000 2005 Foundation transport Principal Investigator
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2002- American Heart Association NHE Modulation in Preconditioning $ 43,000 2004 Pre-Doctoral Fellowship Mentor – JA Moore 2003- National Institutes of Health
123I Iodorotenone–A superior myocardial perfusion tracer? $602,000
2006 RO1 Collaborating Investigator PI: H Van Brocklin 2006- American Heart Association PBR Modulates Mitochondrial Calcium Entry $140,000 2008 Grant-in-Aid through VDAC Principal Investigator 2008 Center for Health and Coenzyme Q10 Supplementation in Refractory Heart $ 60,000 2009 Nutrition Research Failure Co-Principal Investigator PI: I Jialal 2010 UC Davis Collaborative Niacin-induced flushing depends on lipoxygenase $ 22,500 2011 Research Grant vasodilators Principal Investigator 2013 UC Davis Academic Senate TSPO regulates mitochondrial calcium $21,833 2014 Faculty Research Grant entry through VDAC Principal Investigator 2013 SCOR Pilot Grant Estrogen modulation of mitochondrial calcium in $ 5,000 Principal Investigator heart failure via mitochondrial translocator protein
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Clinical Research: Principal Investigator, Cardiovascular Trials, Sacramento VA Medical Center (2001- present): Guardian (cariporide in acute coronary syndrome) Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research [Navigator] Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein [JUPITER] Randomized Evaluation of Long term anticoagulant therapy [RE-LY] A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects (TRILOGY ACS) dal-OUTCOMES: efficacy and safety of dalcetrapib in patients with recent acute coronary syndrome ENGAGE AF – TIMI 48
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PUBLICATIONS 1. 1978 Schaefer S, M Arditti, K Stankus, D Frost, W Ganz and R Vas. A device for the simulation of
cardiac arrhythmias. Annals of Biomedical Engineering 6:429-437. 2. 1985 Wolfe C, M Winniford, M Wheelan, S Schaefer, BG Firth and LD Hillis. Relation of coronary
artery disease and left ventricular systolic dysfunction to left ventricular end-diastolic pressure after left ventribulography. American Journal of Cardiology 55: 1622-23.
3. 1986 Schaefer S, RM Peshock, RW Parkey and JT Willerson. A new device for exercise
magnetic resonance imaging. American Journal Roentgenology 147:1289-90. 4. 1987 Schaefer S, R Shohet, J Nixon and R Peshock. Right ventricular obstruction from cervical
carcinoma: a rare, single metastatic site. American Heart Journal 113:397-99. 5. 1987 Schaefer S, RM Peshock, CR Malloy, J Katz, RW Parkey and JT Willerson. Nuclear
magnetic resonance imaging in the Marfan Syndrome. Journal of the American College of Cardiology 9:70-4.
6. 1987 Katz J, RW Peshock, P McName, S Schaefer, CR Malloy and RW Parkey. Analysis of spin
echo rephasing with pulsatile flow in 2D-FT magnetic resonance imaging. Magnetic Resonance in Medicine 4:307-22.
7. 1987 Katz J, RM Peshock, CR Malloy, S Schaefer and RW Parkey. Even-echo rephasing and
constant velocity flow. Magnetic Resonance in Medicine 4:422-430. 8. 1987 May DC, JJ Popma, WH Black, S Schaefer, H Lee, BD Levine and LD Hillis. Induction and
reversal of nitroglycerin tolerance in human coronary arteries in vivo. New England Journal of Medicine 317:805-809.
9. 1988 Schaefer S, AL Taylor, HR Lee, EH Niggemann, BD Levine, JJ Popma, JH Mitchell and LD
Hillis. Effect of increasing heart rate on left ventricular performance in patients with normal cardiac function. American Journal of Cardiology 61:617-620.
10. 1988 Schaefer S, CR Malloy, J Schmitz and GJ Dehmer. Clinical and hemodynamic
characteristics of patients with inducible pulsus alternans. American Heart Journal 115:1251-1257.
11. 1988 Schaefer S, RM Peshock, CR Malloy, J Katz, RW Parkey, LM Buja and JT Willerson.
Identification of reperfused myocardium with gadolinium-DTPA enhanced nuclear magnetic resonance imaging. Journal of the American College of Cardiology 12:1064-72.
12. 1988 Schaefer S, J Gober, M Valenza, GS Karczmar, GB Matson, SA Camacho, EH Botvinick, B
Massie and MW Weiner. Magnetic resonance imaging guided 31P spectroscopy of the human heart. Journal of the American College of Cardiology 12:1449-55.
13. 1989 Schaefer S, SA Camacho, J Gober, RG Obregon, MA DeGroot, EH Botvinick, B Massie and
MW Weiner. Response of myocardial metabolites to graded regional ischemia: 31P MRS studies of porcine myocardium in vivo. Circulation Research 64:968-976.
14. 1989 Schaefer S, RM Peshock, PV Kulkarni, J Katz, CR Malloy, RW Parkey and JT Willerson. In
vivo nuclear magnetic resonance imaging of myocardial perfusion using the paramagnetic contrast agent manganese gluconate. Journal of the American College of Cardiology 14:472-480.
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15. 1989 Twieg DB, DJ Meyerhoff, B Hubesch, K Roth, D Sappey-Marinier, MD Boska, JR Gober, S Schaefer and MW Weiner. Localized phosphorus-31 magnetic resonance spectroscopy in humans by spectroscopic imaging: Localized spectroscopy and metabolic imaging. Magnetic Resonance in Medicine 12:291-305.
16. 1989 Jadvar H, JR Gober, S Schaefer, GG Schwartz, MW Weiner and BM Massie. Potential
utility of esophageal pacing during cardiac magnetic resonance studies. American Journal of Electromedicine. p. 134-137.
17. 1990 Gober JG, S Schaefer, SA Camacho, M DeGroot, R Obregon, EH Botvinick, MW Weiner
and B Massie. Epicardial and endocardial localized 31
P magnetic resonance spectroscopy: Evidence for metabolic heterogeneity during regional ischemia. Magnetic Resonance in Medicine 13:204-215.
18. 1990 Schwartz GG, S Schaefer, JR Gober, D Meyerhoff, B Massie and MW Weiner. Myocardial
high-energy phosphate metabolism during brief coronary occlusion and reactive hyperemia in the pig. American Journal of Physiology 259:H1190-1196.
19. 1990 Schaefer S, GG Schwartz, JR Gober, AK Wong, SA Camacho, B Massie and MW Weiner.
Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia: 31P NMR studies of porcine myocardium in vivo. Journal of Clinical Investigation 85:706-713.
20. 1990 Schaefer S, JR Gober, GG Schwartz, DB Twieg, MW Weiner and B Massie. In vivo
phosphorus-31 spectroscopic imaging in patients with global myocardial disease. American Journal of Cardiology 65:1154-1161.
21. 1990 Schwartz GG, S Schaefer, DJ Meyerhoff, JR Gober, B Massie and MW Weiner. Dynamic
relation between myocardial contractility and energy metabolism during and following brief coronary occlusion in the pig. Circulation Research 67:490-500.
22. 1991 Schaefer S, RA Lange, DP Gutekunst, RW Parkey, JT Willerson and RM Peshock.
Contrast-enhanced magnetic resonance imaging of hypoperfused myocardium. Investigative Radiology 26:551-556.
23. 1991 Schwartz GG, S Schaefer, SD Trocha, S Steinman, J Gober, J Garcia, BM Massie and MW
Weiner. Metabolic and functional consequences of blunted myocardial reactive hyperemia. American Journal of Physiology 261:H892-H900.
24. 1991 Gober JR, GG Schwartz, S Schaefer, BM Massie, GB Matson, MW Weiner and GS
Karczmar. 31P MRS of myocardial inorganic phosphate using radiofrequency gradient echoes. Magnetic Resonance in Medicine 20:171-183.
25. 1991 Meyerhoff DJ, AA Maudsley, S Schaefer and MW Weiner. Phosphorus-31 magnetic
resonance metabolite imaging in the human body. Magnetic Resonance Imaging 10:245-256.
26. 1992 Schaefer S, GG Schwartz, SK Steinman, DJ Meyerhoff, BM Massie and MW Weiner.
Metabolic response of the human heart to intropic stimulation. In vivo phosphorus-31 studies of normal and cardiomyopathic myocardium. Magnetic Resonance in Medicine 25:260-272.
27. 1992 Schaefer S, GG Schwartz, JA Wisneski, RA Neese, SD Trocha, I Christoph, J Garcia, BM
Massie and MW Weiner. Response of high-energy phophates and lactate release during prolonged regional ischemia in vivo. Circulation 85:342-349.
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28. 1992 Schwartz GG, S Schaefer, SD Trocha, J Garcia, S Steinman, B Massie and MW Weiner.
Effect of supranormal coronary blood flow on energy metabolism and systolic function of the porcine left ventricle. Cardiovascular Research 26(10):1001-1006.
29. 1992 Schaefer S, R van Tyen and D Saloner. Evaluation of myocardial perfusion abnormalities
with gadolinium-enhanced snapshot MR imaging in humans. Radiology 185:795-801. 30. 1993 Schaefer S, LJ Carr, U Kreutzer and T Jue. Myocardial adaptation during acute hibernation:
Mechanisms of phosphocreatine recovery. Cardiovascular Research 27:2044-2051. 31. 1994 Iguidbashian JP, DM Follette, LS Nguyen, HA Berkoff, S Schaefer. Balloon mitral
valvulotomy as a bridge to valve replacement. Journal of Heart Valve Disease 3;155-157 32. 1994 Schaefer S, GG Schwartz, S Steinman, J Garcia, SD Trocha, MW Weiner and BM Massie.
Effects of regional myocardial lidocaine infusion on high energy phosphates. Journal of Molecular and Cellular Research 26:1601-1611.
33. 1995 Massie BM, S Schaefer, J Garcia, MD McKirnan, GG Schwartz, JA Wisneski, MW Weiner,
and FC White. Myocardial high energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy. Circulation 91:1814-1823.
34. 1995 Schaefer S, LJ Carr, E Prussel, and R Ramasamy. Effects of glycogen depletion on
ischemic injury in the isolated rat heart: Insights into preconditioning. American Journal of Physiology 268:H935-H944.
35. 1995 Ramasamy R, H Liu, S Anderson,S Schaefer. Ischemic preconditioning stimulates sodium
and proton transport in the isolated rat heart. Journal of Clinical Investigation 96:1464-1472. 36. 1995 Schaefer S, E Prussel, LJ Carr. Requirement of glycolytic substrate for metabolic recovery
during moderate low flow ischemia. Journal of Molecular and Cellular Research 27: 2167-2176.
37. 1996 Schaefer S, R Valente, L Laslett, JC Longhurst. Cardiac reflex effects of intracoronary
bradykinin in humans. Journal of Investigative Medicine 44(4): 160-167. 38. 1996 Cishek MB, B Yost, S Schaefer. Cardiac aspergillosis presenting as myocardial infarction.
Clinical Cardiology 19:824-827. 39. 1997 Correa S, S Schaefer. Blockade of KATP channels with glibenclamide does not abolish
preconditioning during demand ischemia. American Journal of Cardiology 79:75-78. 40. 1997 Schaefer S, R Ramasamy. Glycogen utilization and ischemic injury in the isolated rat heart.
Cardiovascular Research 35:90-98. 41. 1997 Nguyen TT, EA Amsterdam, S Schaefer: Risk stratification prior to vascular surgery: Does
the location of a dipyridamole thallium scintigram defect provide prognostic information? Cardiology 88:569-575.
42. 1997 Ramasamy R, P Oats, S Schaefer. Aldose reductase inhibition protects diabetic and
nondiabetic rat hearts from ischemia injury. Diabetes 46(2):292-300. 43. 1997 Schaefer S, R Ramasamy. Short term inhibition of the Na-H exchanger limits acidosis and
reduces ischemic injury in the rat heart. Cardiovascular Research 34:329-336.
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44. 1997 Schaefer S, H Hussein, GR Gershony, JC Rutledge, CT Kappagoda. Regression of severe atherosclerotic plaque in patients with mild elevation of LDL cholesterol. Journal of Investigative Medicine 45:536-541.
45. 1998 Ramasamy R, N Trueblood, S Schaefer. Metabolic effects of aldose reductase inhibition
during low-flow ischemia and reperfusion. American Journal of Physiology 275:H195-H203. 46. 1998 Symons JD, S Correa, S Schaefer. Na-H exchange inhibition with cariporide limits
functional impairment caused by repetitive ischemia. Journal of Cardiovascular Pharmacology 32:853-862.
47. 1999 Ramasamy R, H Liu, PJ Oates, S Schaefer. Attenuation of ischemia induced increases in
sodium and calcium by the aldose reductase inhibitor Zopolrestat. Cardiovascular Research 42:130-139.
48. 1999 Lundmark J, N Trueblood, L Wang, R Ramasamy, S Schaefer. Repetitive acidosis protects
the ischemic heart: Implications for mechanisms in preconditioned heart. Journal of Molecular and Cellular Cardiology 31:907-917.
49. 1999 Wang L, R Ramasamy, S Schaefer: Regulation of glycogen utilization in ischemic hearts
after 24 hours of fasting. Cardiovascular Research 42:644-650. 50. 1999 Ramasamy R, S Schaefer: Inhibition of Na+ - H+ exchanger protects diabetic and non-
diabetic hearts from ischemic injury. Insight into altered sucsceptibility of diabetic hearts to ischemic injury. Journal of Molecular and Cellular Cardiology 31:785-797.
51. 1999 Lundmark J, R Ramasamy, PR Vulliet, S Schaefer. Chelerythine increases Na-K-ATPase
activity and limits ischemic injury in isolated rat hearts. American Journal of Physiology 46:H999-H1006.
52. 1999 Schaefer S, LF Wang, A van der Vliet, M Hristova, PR Vulliet, SD Fan. Fasting limits
norepinephrine release with myocardial ischemia and reperfusion. Cardiovascular Drugs and Therapy 13:399-405.
53. 2000 Trueblood N.A., R. Ramasamy, L. Wang, S. Schaefer. Niacin protects the isolated heart
from ischemia/reperfusion injury. American Journal of Physiology 279:H764-H771
54. 2001 Wang L, G Cherednichenko, L Hernandez, J Halow, SA Camacho, V Figuredo, S Schaefer. Preconditioning limits mitochondrial calcium overload during ischemia/reperfusion in rat heart: The role of KATP channels American Journal of Physiology 280:H2321-H2328.
55. 2001 Ramasamy R, H Liu, G Cherednichenko, S Schaefer. Fasting limits the increase in
intracellular calcium during ischemia in isolated rat hearts. Basic Research in Cardiology 96:463-470.
56. 2001 Schaefer S, SD Correa, L Laslett, RJ Valente. Blockade of adenosine receptors with
aminophylline limits ischemic preconditioning in man. American Heart Journal 142:e4. 57. 2001 Ramasamy R, JA Payne, J Whang, SR Bergmann, S Schaefer. Protection of ischemic
myocardium in diabetics by inhibition of the electroneutral Na+-K
+-2Cl
- cotransporter.
American Journal of Physiology 281:H515-H522. 58. 2001 Symons JD, S Schaefer. Na
+/H
+ exchange subtype 1 inhibition reduces endothelial
dysfunction in vessels from stunned myocardium. American Journal of Physiology 281:H1575-H1582
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59. 2002 Reyes, T, S Schaefer. High dose glucocorticoids cause ventricular tachycardia: case report
and review of the literature. Cardiovascular Reviews and Reports 23:689-691.
60. 2002 Korotkov SM, VP Nesterov, S Schaefer. On the effects of diazoxide on isolated mitochondrial from rat myocardium. Biochemistry and Biophysics 387:306-309.
61. 2004 Cherednichenko G, AV Zima, W Feng, S Schaefer, LA Blatter, JE Casida, IN Pessah.
NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ Research 94 (4):478-86.
62. 2004 Arieli Y, L Hernandez, H Gursahani, M Eaton, S Schaefer. Gender modulation of
mitochondrial calcium transport: effect of redox state. J Mol Cell Cardiol 37:507-513.
63. 2004 Gursahani H, S Schaefer. Acidification reduces mitochondrial calcium uptake in rat cardiac
mitochondria. Am J Physiology Heart Circ Physiology 287: H2659-H2665 64. 2005 Liu H, L Wang, S Schaefer. Sevoflurane preconditioning limits intracellular/mitochondrial
Ca2+
in ischemic newborn myocardium. Anesthesia-Analgesia 101:349-355 65. 2005 Eaton M, Hernandez L, S Schaefer. Preconditioning and diazoxide limit mitochondrial
calcium overload in ischemic rat hearts: role of reactive oxygen species. Experimental and Clinical Cardiology 10:96-102
66. 2006 Eaton M, Gursahani H, Arieli Y, Pinkerton K, S Schaefer: Acute tobacco smoke exposure
promotes mitochondrial permeability transition. J Tox Environ Health 15:1497-1510 67.. 2007 Southard J, Baker L, S Schaefer: In Search of the False-Positive ETT: Evidence-Based Use
of Exercise Echocardiography. Clinical Cardiology 31: 35-40 68. 2008 Tamse C, Lu X, Mortel E, Cabrales E, Feng W, S Schaefer: The Peripheral Benzodiazepine
Receptor Modulates Ca2+ Transport through the VDAC in Rat Heart Mitochondria. J Clin Basic Cardiol 11:24-29.
69. 2009 Konia M, Schaefer S, H Liu: Nuclear factor-B inhibition provides additional protection against ischemia reperfusion injury in sevoflurane preconditioning. E J Anesthesiology 26:496-503
70. 2009 Lu X, Liu H, Wang L, Schaefer S: Activation of NF-kB is a critical element in the anti-
apoptotic effect of anesthetic preconditioning. Am J Physiol: Heart Circ 296(5):H1296-304 71. 2009 Lopez J, Yeo KK, Buonocore M, Caputo G, Schaefer S: Absence of CMR delayed contrast
enhancement can predict recovery from methamphetamine cardiomyopathy. J Cardiovascular Magnetic Resonance 11:46-50
72. 2009 Connolly SJ, et al: Dabigatran versus warfarin in patients with atrial fibrillation. N Eng J Med
361(12)-1139-51 [member – Dabigatran Study Group] 73. 2010 Phillips W, Schaefer S: LDL= 5: Virtues and Dangers of Multidrug Therapy of Low-Density
Lipoprotein Cholesterol. Preventive Cardiol 13:69-71 74. 2010 Lu X, Moore PG, Liu H, Schaefer S. Phosphorylation of ARC is a critical element in the anti-
apoptotic effect of anesthetic preconditioning. Anesthesia Analgesia 112:525-531
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75. 2011 Furman A, Meier J, Malmstrom R, Lopez J, Schaefer S: Comparative efficacy of ezetimibe/simvastatin, rosuvastatin, and atorvastatin in uncontrolled hyperlipidemia patients. Am J Manag Care. 2011;17(8):538-544
76. 2011 Broisat A, Ruiz B, Goodman NC, Hanrahan SM, Reutter BW, Brennan KM, Janabi M,
Schaefer S, Watson DD, Beller GA, VanBrocklin HF, Glover DK: Myocardial Uptake of 7´-(Z)-[123I]Iodorotenone During Vasodilator Stress in Dogs with Critical Coronary Stenoses. Circulation: Cardiovascular Imaging 4:685-692
77. 2012 Hutchins IM, Schaefer S: Progressive Left Ventricular Noncompaction and Systolic
Dysfunction J Experimental and Clinical Cardiology 17(2):8-13 78. 2012 Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S: Inhibition of
epoxide hydrolase prevents niacin-induced flushing in mice. J Cardiovasc Pharmacology 60(1):70-75.
79. 2013 Browning AC, Schaefer S: What Lies Beneath – Posterior ST Elevation Myocardial Infarction
With Underlying Right Ventricular Paced Rhythm. J Experimental and Clinical Cardiology. (18)(1):e55-e56
80. 2013 Stripe B, Rechenmacher S, Jurewitz D, Lee C, Schaefer S: The Diagnostic Yield of Cardiac
Catheterization in Low-risk "Troponinemia". JAMA Inter Med 173 (22):2088-2090 81. 2014 Ma L, Lee BH, Clifton H; Schaefer S, Zheng J: Nicotinic Acid Activates the Capsaicin Receptor
TRPV1: Potential Mechanism for Cutaneous Flushing. Arteriosclerosis, Thrombosis Vasc Biology 34(6):1272-80
82. 2014 Tate S, Griem A, Durbin-Johnson B, Watt C, Schaefer S: Marked Elevation of B-Type
Natriuretic Peptide in Patients with Heart Failure and Preserved Ejection Fraction. J Basic Research 28(4): 255-61
83. 2015 Clifton H, Inceoglu AB, Ma L, Zheng J, Schaefer S: TRPV1 channels Mediate Niacin-Induced
Vasodilation. J Cardiovasc Pharmacol 65(2):184-91 84. 2015 Ma L, Lee BH, Clifton H, Schaefer S, Zheng J: Nicotinic Acid Is A Common Gating Regulator of Heat-Sensing TRPV1-4 Ion Channels. Sci Rep 5: 8906
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BOOK CHAPTERS 1. 1989 Schaefer S, BM Massie and MW Weiner. Magnetic resonance spectroscopy of the heart.
In: Cardiology Clinics, Wolfe C (ed), WB Saunders, 7:697-712. 2. 1989 Weiner MW, S Schaefer, D Meyerhoff, B Hubesch, G Karczmar, M Boska, D Tweig and G
Matson. Clinical uses of magnetic resonance spectroscopy. In: Diagnostic Radiology, Marquis AR and CA Gooding (eds), Radiology Research & Education Foundation, UCSF, p. 105-117.
3. 1990 Schaefer S. Evaluation of myocardial metabolism by NMR spectroscopy. In: Comparative
Cardiac Imaging Function, Flow, Anatomy, Quantification, Brundage BH (ed), Aspen Publishers, p. 417-427.
4. 1990 Schaefer S, MW Weiner and BM Massie. Clinical application of cardiac spectroscopy. In:
Cardiac Imaging - Principles and Practice, Marcus ML, H Schelbert, D Skorton and GL Wolf (eds), WB Saunders, p. 967-976.
5. 1990 Weiner MW, A Baker, P Carson, S Schaefer, G Schwartz, M DeGroot, B Massie and RG
Miller. 31P MRS studies of skeletal muscle and heart: Evidence of metabolic regulation by inorganic phosphate. In: Noninvasive Techniques in Biology and Medicine, Freeman SE, E Fukusima and ER Greene (eds), San Francisco Press, p. 111-122.
6. 1992 Camacho SA and S Schaefer. Magnetic resonance spectroscopy of myocardial ischemia.
In: Cardiovascular Magnetic Resonance Spectroscopy, Schaefer S and RS Balaban (eds). Kluwer Academic Publishers, Boston, Ch.7 p.111-125.
7. 1992 Schaefer S. Clinical Applications of Cardiac Spectroscopy. In: Cardiovascular Magnetic
Resonance Spectroscopy, Schaefer S and RS Balaban (eds). Kluwer Academic Publishers, Boston, Ch.14 p.215-224.
8. 1993 Schaefer S. Clinical spectroscopy in ischemic heart disease. In: Cardiovascular
Applications of Magnetic Resonance, Pohost GM (ed). Mount Kisco, NY Futura Publishing.
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INVITED ARTICLES AND PROCEEDINGS
1. 1985 Schaefer S, C Ram: The heart in hypertension: physiolgical and pharmacological
implications. Practical Cardiology, 11:80-99. 2. 1989 Schaefer S. Cardiovascular applications of nuclear magnetic resonance spectroscopy.
American Journal of Cardiology 64:38E-45E.
3. 1989 Schaefer S, GG Schwartz, JR Gover, B Massie and MW Weiner. Magnetic resonance spectroscopy. Investigative Radiology, 24(12):969-972.
4. 1989 Weiner MW, H Heltherington, B Hubesch, G Karczmar, B Massie, A Maudsley, DJ
Meyerhoff, D Sappey-Marinier, S Schaefer, D Twieg, GB Matson. Clinical magnetic resonance spectroscopy of brain, heart, liver, kidney and cancer. A quantitative approach. NMR in Biomedicine, 5:290-297.
5. 1992 Schaefer S, and RS Balaban (editors) : Cardiovascular Magnetic Resonance Spectroscopy, Kluwer Academic Publishers, Boston. 6. 1993 Schaefer S. Diastolic dysfunction and hypertension: Implications for treatment.
Cardiovascular Reviews and Reports, June. 7. 1997 Schaefer S. Stable Angina: How to evaluate, optimal medical therapy, when to
revascularize. Audio-Digest Internal Medicine/Clinical Cardiology Vol. 44 No. 18, Side A. 8. 1999 Schaefer S. Na-H exchange inhibition in limiting ischemic injury. J of Heart Disease 1: 92 9. 1999 Schaefer S. Altered high energy phosphate metabolism in the intact failing heart. Heart
Failure Society, Third Scientific Meeting 10. 2000 Schaefer S. Magnetic resonance spectroscopy in human cardiomyopathies. J of
Cardiovascular Mag Reson 2:151-157. 11. 2002 Schaefer S: Electron Beam Computed Tomography: Views of the Elephant (Guest Editor).
Prev Cardiol 5: 58 12. 2002 Schaefer S. Will helical CT replace electron beam CT in the assessment of coronary
calcium? Prev Cardiol 5:84-86 13. 2003 Hernandez L, Eaton M, Gursahani-Rao H, Arieli Y, Schaefer S: Estrogen effects on
myocardial ischemia/reperfusion injury. In Recent Res Devel Physiol 1, pp.891-912 publ: Research Signpost
14. 2003 Amsterdam EA, Schaefer S: Ischemic Preconditioning in Coronary Artery Disease: A
Therapeutic Golden Fleece? (Editorial) J Am Coll Cardiol 43 (9):1515-1516 15. 2004 Schaefer S. For-profit Health Plans: Letter to the Editor, N Eng J Med 350:1469. 16. 2005 Schaefer S: Coronary artery calcium screening – Use or abuse of CT? Patient Care
(February) 17. 2006 Perls TT, Salzman BE, Schaefer S: Why do men die younger than women and what can be
done about it? Patient Care (June)
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18. 2014 Schaefer S. Commentary: Review: In older patients without CVD, statins reduce MI and stroke but not all-cause mortality ACP Journal Club Vol 160 (6)
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ABSTRACTS 1. 1986 Peshock RM, PV Kulkarni, S Schaefer, R Rokey, J Katz, CR Malloy, RW Parkey and JT
Willerson. A new paramagnetic contrast agent for magnetic resonance imaging of experimental myocardial infarction. Journal of the American College of Cardiology 7(2):196A.
2. 1986 Schaefer S, CR Malloy, J Katz, RW Parkey, LM Buja, RM Peshock and JT Willerson.
Gadolinium-DTPA identifies reperfused myocardium in magnetic resonance imaging. Clinical Research 34(2):342A.
3. 1986 Schaefer S, CR Malloy, J Katz, JT Willerson and RM Peshock. The effect of gadolinium-
DTPA on magnetic resonance imaging of reperfused myocardium. Society of Magnetic Resonance in Medicine, 5th Annual Meeting.
4. 1986 Schaefer S, RM Peshock, PV Kulkarni, CR Malloy, J Katz and JT Willerson. In vivo
magnetic resonance imaging of myocardial perfusion. Society of Magnetic Resonance in Medicine, 5th Annual Meeting.
5. 1986 Malloy CR, S Schaefer, J Katz, RM Peshock, JT Willerson and RW Parkey. Computer-
assisted identification of the left ventricular myocardium: An algorithm for cardiac image analysis. Society of Magnetic Resonance in Medicine, 5th Annual Meeting.
6. 1986 Peshock R, B Barker, J Katz, S Schaefer, W Erdman, J Weinreb, J Willerson and R Parkey.
Optimizing small flip angle imaging for the evaluation of cardiovascular structure and function. Society of Magnetic Resonance in Medicine, 5th Annual Meeting.
7. 1986 Katz J, RM Peshock, P McNamee, S Schaefer, CR Malloy and RW Parkey. Effects of
periodic motion on rephasing of spin echoes. Society of Magnetic Resonance in Medicine, 5th Annual Meeting.
8. 1986 Kulkarni P, S Schaefer, RM Peshock, J Katz and RW Parkey. Phosphonate complexes of
gadolinium: Potential myocardial magnetic resonance imaging contrast agents. Society of Magnetic Resonance in Medicine, 5th Annual Meeting.
9. 1986 Schaefer S, RM Peshock, CR Malloy, J Katz, LM Buja and JT Willerson. Gadolinium-DTPA:
In vivo evaluation of myocardial reperfusion. Circulation 74(4):II-273. 10. 1986 Katz J, RM Peshock, CR Malloy, S Schaefer and RW Parkey. Direct measurement of blood
velocity and wall velocity by phase reconstruction of magnetic resonance images. Circulation 74(4):II-318.
11. 1987 Schaefer S, RM Peshock, PV Kulkarni, CR Malloy, RW Parkey and JT Willerson.
Assessment of myocardial perfusion in vivo using nuclear magnetic resonance imaging. Journal of the American College of Cardiology 9(2):45A.
12. 1987 Schaefer S, RM Peshock, PV Kulkarni, J Katz, CR Malloy, RW Parkey and JT Willerson.
Assessment of myocardial perfusion in vivo using magnetic resonance imaging. Magnetic Resonance Imaging 5 (Suppl 1):133.
13. 1987 Katz J, RM Peshock, P McNamee, S Schaefer, CR Malloy and RW Parkey. Phase
reconstruction of magnetic resonance images in the determination of cardiac wall and blood velocity and the possible effects of acceleration. Magnetic Resonance Imaging 5 (Suppl 1):50.
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14. 1987 Kulkarni PV, S Schaefer, RM Peshock, J Katz and RW Parkey. Phosphonate complexes of
gadolinium. Potentional contrast agents for magnetic resonance imaging of myocardium. Journal of Nuclear Medicine 28:406.
15. 1987 Schaefer S, R Lange, P Kulkarni, D Jansen, JT Willerson and RM Peshock. Nuclear
magnetic resonance imaging of partial coronary occlusion. Clinical Research 35:324A. 16. 1987 Schaefer S, R Lange, PV Kulkarni, J Katz, DE Jansen, RW Parkey, JT Willerson and RM
Peshock. Nuclear magnetic resonance imaging of partial coronary occlusion. Society of Magnetic Resonance in Medicine, 6th Annual Meeting.
17. 1987 Schaefer S, AL Taylor, HR Lee, Niggemann, BD Levine, JJ Popma, JH Mitchell and LD
Hillis. The effect of increasing heart rate on left ventricular performance in patients with normal cardiac function. Circulation 76(4):IV-545.
18. 1988 Schaefer S, J Gober, M Valenza, GS Karczmar, GB Matson, A Camacho, EH Botvinick, B
Massie and MW Weiner. MRI guided phosphorus-31 spectroscopy of the human left ventricle. Journal of the American College of Cardiology 11:226A.
19. 1988 Schaefer S, J Gober, SA Camacho, EH Botvinick, B Massie and MW Weiner. 31P MRS of
normal and diseased human myocardium: location with ISIS and MRSI. Society of Magnetic Resonance in Medicine, 7th Annual Meeting.
20. 1988 Gober J, S Schaefer, SA Camacho, RG Obregon, MA DeGroot, EH Botvinick, MW Weiner
and B Massie. Epicardial and endocardial localized 31P MRS during partial regional ischemia: Evidence for metabolic heterogenity. Society of Magnetic Resonance in Medicine, 7th Annual Meeting.
21. 1989 Schaefer S, J Gober, DB Twieg, GS Schwartz, MW Weiner and B Massie. Spectroscopic
imaging of normal and diseased human myocardium. Magnetic Resonance Imaging 7:65. 22. 1989 Schaefer S, J Gober, SA Camacho, GS Schwartz, B Massie and MW Weiner. Changes in
high-energy phosphates and myocardial contractility during graded regional ischemia: an in vivo 31P MRS study. Magnetic Resonance Imaging 7:66.
23. 1989 Gober JR, GG Schwartz, S Schaefer, BM Massie, GB Matson, MW Weiner and GS
Karczmar. 31P MRS detection of myocardial Pi using motion editing. Magnetic Resonance Imaging 7:187.
24. 1989 Schwartz GG, JR Gober, D Meyerhoff, S Schaefer, B Massie and MW Weiner. Relationship
between myocardial high-energy phosphates, contractile function and coronary blood flow during and following brief coronary occlusion in the pig. Society of Magnetic Resonance in Medicine, 8th Annual Meeting, p. 1004.
25. 1989 Schaefer S, GG Schwartz, JR Gober, DJ Meyerhoff, MW Weiner and B Massie.
Phosphorus-31 spectroscopic imaging of global myocardial disease: Elevation of phosphodiesters in patients with left ventricular dilation. Circulation 80:II-588.
26. 1989 Schaefer S, GG Schwartz, JR Gober, AK Wong, SA Camacho, MW Weiner and B Massie.
Relationship between myocardial metabolites and contractile function during graded regional ischemia: Phosphorus-31 nuclear magnetic resonance of porcine myocardium in vivo. Circulation 80:II-613.
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27. 1990 Schaefer S, GG Schwartz, S Steinman, DJ Meyerhoff, B Massie and MW Weiner. Metabolic
response of the heart to increased work: 31P NMR spectroscopy of normal and cardiomyopathic myocardium in man. Society of Magnetic Resonance in Medicine 9th Annual Meeting, p. 245.
28. 1990 Schaefer S, GG Schwartz, SD Trocha, I Christoph, S Steinman, B Massie and MW Weiner.
Dissociation between high-energy phosphates and pH during prolonged regional myocardial ischemia in vivo. Society of Magnetic Resonance in Medicine 9th Annual Meeting, p. 924.
29. 1990 Gober JR, GB Matson, GG Schwartz, S Schaefer, BM Massie and MW Weiner. An isolation
device for the simultaneous measurement of coronary blood flow and myocardial segment shortening during 31P nuclear magnetic resonance spectroscopy. Society of Magnetic Resonance in Medicine 9th Annual Meeting, p. 546.
30. 1990 Schwartz GG, S Schaefer, SD Trocha, J Garcia, B Massie and MW Weiner. Can
myocardial energetics be augmented by supranormal coronary blood flow? Society of Magnetic Resonance in Medicine 9th Annual Meeting, p. 1242.
31. 1990 van Tyen R, D Saloner, CM Anderson and S Schaefer. Improved temporal resolution of
high-speed imaging of dynamic processes. Society of Magnetic Resonance in Medicine 9th Annual Meeting, p. 1304.
32. 1990 Schaefer S, GG Schwartz, S Steinman, DJ Meyerhoff and BM Massie. Metabolic response
of normal and cardiomyopathic myocardium to increased oxygen demand. Circulation 82:III-684.
33. 1990 Schaefer S, GG Schwartz, SD Trocha, S Steinman, J Garcia, I Christoph, BM Massie and
MW Weiner. Response of high-energy phosphates and pH to prolonged myocardial ischemia. Circulation 82:III-154.
34. 1991 Schaefer S, GG Schwartz, S Steinman, J Garcia, SD Trocha, BM Massie and MW Weiner.
Metabolic effects of reduced regional contractility: Equilibrium of ATP synthesis and consumption. Society of Magnetic Resonance in Medicine 10th Annual Meeting.
35. 1991 Schaefer S, R van Tyen and D Saloner. Dipyridamole MRI: Detection of myocardial
hypoperfusion in man. Circulation 84:II-157. 36. 1991 Schaefer S, GG Schwartz, S Steinman, J Garcia, JA Wisneski and MW Weiner.
Dissociation of phosphate metabolism and lactate release during prolonged ischemia. Circulation 84:II-216.
37. 1992 Schaefer S, LJ Carr, U Kreutzer and T Jue. Metabolic adaptation during acute myocardial
hibernation. Society of Magnetic Resonance in Medicine 11th Annual Scientific Meeting I:847.
38. 1992 Schaefer S, L Carr, U Kreutzer and T Jue. Metabolic adaptation in acute hibernating
myocardium. Circulation 86:I-281. 39. 1993 Schaefer S, LJ Carr, T Jue and E Prussel. Does tissue glycogen content determine infarct
size in the preconditioned heart? Society of Magnetic Resonance in Medicine 12th Annual Meeting, p. 1050.
40. 1993 Schaefer S, L Carr and E Prussel. Limitation of acidosis reduces infarct size: Insights into
preconditioning. Circulation 88:I-488.
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41. 1993 Massie BM, S Schaefer, J Garcia, McKirnan, F White, GG Schwartz, MW Weiner and JA
Wisneski. Swine with moderate LVH do not manifest greater susceptibility to ischemia with increased work. Circulation 88:I-243.
42. 1994 Schaefer S, H Liu, E Prussel and S Anderson. Sodium kinetics in interventions that limit
infarct size: insights into preconditioning. American College of Cardiology 43rd Annual Scientific Session, I-397A.
43. 1994 Dimand RJ, L Carr, S Schaefer and T Jue. Comparison of medium chain fatty acids to
glucose as the sole energy source in perfused newborn hearts. Society of Critical Care Medicine, 23rd Educational and Scientific Symposium, p. 291.
44. 1995 Nguyen T, E Amsterdam and S Schaefer. Risk stratification prior to vascular surgery: Does
the location of dipyridamole thallium scintigraphy abnormality provide prognostic information? Journal of Investigative Medicine 43(3), March.
45. 1995 Ramasamy R and S Schaefer. Ischemic preconditioning stimulates proton transport in the
isolated rat heart. FASEB Journal 9:A303. 46. 1995 Schaefer S and R Ramasamy. Transient inhibition of the Na/H exchanger protects the rat
heart from ischemia. FASEB Journal 9:A303. 47. 1995 Ramasamy R, S Schaefer and P Oates. Improved ischemic tolerance in diabetic hearts
treated with an aldose reductase inhibitor. Diabetes 44 (Suppl 1): 192A, #700. 48. 1995 Schaefer S, R Valente, L Laslett and JC Longhurst. Bradykinin does not mediate anginal
pain during myocardial ischemia. Journal of Investigative Medicine 43:320A. 49. 1995 R. Ramasamy and S Schaefer.
31P-NMR studies on myocardial protection in bumetanide-
treated diabetic hearts. Society of Magnetic Resonance, Book of Abstracts, pg.1633. 50. 1995 Schaefer S, H. Lui and R. Ramasamy. Effect of substrate on intracellular sodium kinetics
with global myocardial ischemia. Society of Magnetic Resonance, Book of Abstracts, pg.1635.
51. 1995 Schaefer S, and R. Ramasamy. Inhibition of the Na
+-H
+ exchanger during pre-conditioning
increases acidosis and impairs functional recovery during subsequent ischemia. Society of Magnetic Resonance, Book of Abstracts, pg.1649.
52. 1996 Nguyen T, H Zhou, S Schaefer and E. Amsterdam. Does cardiac revascularization before
major elective vascular surgery lead to better outcome? Journal of Investigative Medicine 44(3), March.
53. 1995 Correa SD, and S Schaefer. Blockade of KATP channels does not abolish preconditioning
during damand ischemia in man. Journal of the American College of Cardiology 27(Suppl A):369A.
54. 1996 Ramasamy R, H Liu, and S Schaefer. Aldose reductase inhibition limits the rise in
intracellular sodium and calcium and protects diabetic hearts from ischemic injury. Diabetes 45 (Suppl 2):196A .
55. 1996 Schaefer S and R Ramasamy. Fasting protects ischemic myocardium: the role of glycogen.
FASEB Journal 10:A12, 66.
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56. 1996 Ramasamy R and S Schaefer. Bumetanide protects diabetic hearts from ischemic injury. FASEB Journal 10:A203, 1173.
57. 1996 Lundmark J, R Ramasamy, and S Schaefer. Inhibition of protein kinase C during ischemic
preconditioning alters pH regulation in the isolated rat heart. Circulation 94:I-424. 58. 1997 Schaefer S, JC Rutledge, G Gershony, CT Kappagoda. Severity of atherosclerosis predicts
plaque regression with risk factor reduction. Journal of Investigative Medicine 45:113A. 59. 1997 Symons JD, L Martin, and S Schaefer. Na
+/H
+ exchange inhibition (NHEi) attenuates
myocardial dysfunction of short-term hibernation in swine. FASEB Journal, 11:A74. 60. 1997 Schaefer S, R Ramasamy, and JA Lundmark. Inhibition of protein kinase C (PKC)
increases Na,K-ATPase activity and limits sodium accumulation in the ischemic rat heart. FASEB Journal, 11:A431.
61. 1997 Ramasamy R, Schaefer S and N Trueblood. Inhibition of aldose reductase protects
ischemic myocardium. Circulation 96:1-628,3512. 62. 1997 Schaefer S, JA Lundmark, N Trueblood, et al. Repetitive acidosis protects the ischemic rat
heart: A mechanism of ischemic preconditioning? Circulation 96:1-688,3850. 63. 1997 Schaefer S, H Liu, R Ramasamy. Fasting limits intracellular calcium accumulation during
myocardial ischemia. Circulation 96:1-200,1108. 64. 1998 Fan S, Wang L, Vulliet PR, S Schaefer. Fasting limits norepinephrine release on reperfusion
following ischemia: A mechanism of reduced injury? FASEB Journal 12: A77 65. 1998 Trueblood N, S Schaefer, R Ramasamy: Polyol pathway inhibition increases glycolysis in
isolated diabetic rat hearts. FASEB Journal 12: A258 66. 1998 Wang L, S Schaefer. Mechanisms for increased glycogen utilization in fasted hearts. FASEB
Journal 12: A1000. 67. 1999 Trueblood N, S Schaefer. Fasting limits infarct size in the in situ rat heart. FASEB Journal 13:
A761. 68. 1999 Trueblood N, Ramasamy R, Wang L, S Schaefer. Nicotonic acid protects hearts subjected
to low-flow ischemia. FASEB Journal 13: A1065. 69. 1999 Symons J, S Schaefer. Na
+-H
+ exchange (NHE) inhibition preserves endothelial function
of resistance vessels in response to myocardial ischemia. FASEB Journal 13: A1085. 70. 1999 Schaefer S. Na-H exchange inhibition in limiting ischemic injury - Clinical limitations.
Journal of Heart Disease, 1:365. 71. 1999 Cherednichenko G, I Pessah, W Feng, S Schaefer. Oxidation of NADH modulates cardiac
SR calcium release. Circulation 1999, Circulation 100: 1-420. 72. 2000 Wang, L, Cherednichenko G, Halow J, Camacho S, Figueredo, V, Schaefer, S.
Preconditioning Limits Mitochondrial Calcium Overload during Ischemia-Reperfusion. FASEB Journal LB19.
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73. 2003 Eaton M, Hernandez L, Schaefer S: Preconditioning, but not diazoxide, limits mitochondrial calcium overload in ischemic rat hearts via reactive oxygen species. Experimental Biology 17, Part II, A879.
74. 2004 Arieli Y, Schaefer S. Higher Redox State Modulates Lower Ca
2+ Uptake in Cardiac
Mitochondria From Female Rats. Biophysical Society
75. 2004 Gursahani H, Schaefer S. Acidification Limits Mitochondrial Calcium Uptake in Rat Cardiac Mitochondria. AHA Scientific Sessions
76. 2006 Southard JT, Baker L, Schaefer S. In Search of the False Negative ETT – Evidence-Based
Use of the ESE. AHA Scientific Sessions 77. 2007 Boutchko R, Sitek A, Reutter BW, Gullberg GT, Budinger TF, Schaefer S, Barnett CA.
Calculation of Left Ventricular Ejection Fraction of Abnormal Hearts in SPECT, M14-288, IEEE MIC 2006 Proceedings.
78. 2010 Inceoglu AB, Hammock BH, Schaefer S. Inhibitors of soluble epoxide hydrolase limit niacin-
induced flushing. AHA Scientific Session
