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CURRICULUM VITAE DATE: January 22nd 2020 NAME: Mohammed Tawfiq Numan, M.D PRESENT TITLE: Professor, Pediatric Cardiology Director, Pediatric Electrophysiology Director, Dysautonomia Center of Excellence Interim Co-director, Pediatric Cardiology Division Department of Pediatrics- Cardiology University of Texas Health Science Center at Houston-Texas ADDRESS: (office) 6410 Fannin Street Suite# 425 Houston, Texas. 77030 Email: Mohammed.T.Numan@uth.tmc.edu Under- graduate and Graduate Education: Years, Degree Institution Location 1982-1990 MBBS King Faisal University, Dammam- Saudi Arabia POSTGRADUATE TRAINING:

1990-1994: Pediatrics Residency, King Fahad University Hospital, Al-Khobar, Saudi Arabia 1995-1996: Pediatrics Residency, University of Florida, Pensacola, Florida

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1996-1997: Neonatology& Perinatal Medicine Fellowship, State University of New York (SUNY), Buffalo, New York. 1997-2000: Pediatric Cardiology Fellowship, University of Florida, Gainesville, Florida. 1999, October-December: Congenital Heart interventional Catheterization training with Dr. Evan Zahn, Miami Children’s hospital, Miami, Florida. 2000-2001: Pediatric Cardiac Electrophysiology Fellowship, Medical University of South Carolina, Charleston, South Carolina.

Academic and Administrative Appointments:

October 2002- July 2004: Pediatric Residency Program Director Department of Pediatrics Hamad Hospital Doha, Qatar March 2007-March 2009: Assistant Professor of Pediatrics Department of Pediatrics Weill Cornell Medical School-New York/Qatar Doha, Qatar March 2009- August 2015: Associate Professor of Pediatrics Division of Pediatric Cardiology Director, Pediatric Cardiac Electrophysiology Department of Pediatrics University of Texas Medical School at Houston September 2015- current: Professor of Pediatrics Division of Pediatric Cardiology Director, Pediatric Cardiac Electrophysiology Department of Pediatrics University of Texas Health Science Center at Houston September 2015- current date: Chair, The clinical competency committee for pediatric cardiology fellowship program, The University of Texas Health Science Center. February 2019- Current date: Interim Co-director, Pediatric Cardiology Division McGovern Medical School,

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The University of Texas Health Science Center HOSPITAL APPOINTMENTS:

November 2001- March 2009 Senior Consultant of Pediatric Cardiology Department of Cardiology and Cardiac Surgery Hamad Hospital Doha, Qatar. 2001-2009 Director, Cardiac Electrophysiology Department of Cardiology and Cardiac Surgery Hamad Hospital Doha, Qatar 2001-2004 Director of Departmental Quality Assurance Department of Cardiology and Cardiac Surgery Hamad Hospital Doha, Qatar 2004-2009 Director, Pediatric Cardiology Department of Cardiology and Cardiac Surgery Hamad Hospital Doha, Qatar March 2009 till Current Attending Physician, Pediatric Cardiologist Memorial Hermann Hospital Texas Medical Center- Houston March 2009 till current Attending Physician, Pediatric Cardiologist Lyndon Baines Johnson Harris County Hospital Houston, Texas October 2011 till current date Co-Director, Dysautonomia Center Memorial Hermann Hospital Texas Medical Center- Houston November 2011 till 2013

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Attending Physician, Pediatric Cardiologist St Joseph Hospital Houston, Texas August 2018 till current date: Consultant pediatric cardiologist, MD Anderson cancer center Houston, Texas

LICENSURE:

1991 -2005 Jordan Medical Council, 1991

2000-2002 South Carolina Board of Medical Examiners, License# 21945 2007-2014 Texas Medical Board, License# M7481

CERTIFICATION:

October 1997 American Board of Pediatrics. Recertification January 2011 expires 2021 August 2000 American Board of Pediatrics, Sub-Board of Pediatric Cardiology

Recertification September 2012 expires 2022. July 2001 Certificate of completion, Pediatric Cardiac Electrophysiology,

Medical University of South Carolina December 2017 Certified Electrophysiology Specialist for Physician-Pediatrics (CEPS-P). International Board of Heart Rhythm Examiners (IBHRE) Expires 2027. March 2019 AAMC - Association of American Medical Colleges Washington, DC for the 2019 Leadership and Management Foundations for Academic Medicine and Science PROFESSIONAL ORGANIZATIONS Membership:

1991-2005 Jordan Medical Association 1991-2005

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2003-2009 Gulf Heart Association 2003-2009 2005-2018 Heart Rhythm Society (Previously known NASPE) 2011-2018 Cardiac Electrophysiology Society 2012-2017 American Autonomic Society 2013 and 2016 Member of the scientific committee of American Autonomic Society 2019-2022 Elected member of the board of directors at the American Autonomic Society. 2019-2022 Chairman of the pediatric committee at the American Autonomic Society.

HONORS AND AWARDS:

2005 Best Publication of the year 2005 Award Medical Research Center Hamad Medical Corporation Doha, Qatar 2012-2013 Dean’s Teaching Excellence Award The University of Texas Medical School at Houston 2013 Best Abstract of the year 2013 Carrell-Krusen Neuromuscular Symposium Dallas, Texas 2014 Best Abstract of the year 2014

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Carrell-Krusen Neuromuscular Symposium Dallas, Texas 2014 Voted one of the top doctors by Houstonia magazine, August 2014. 2015 Member of the task force designated by the American Autonomic Society to establish consensus statement of “Orthostatic Intolerance diseases” 2015 Houston top Doctors by Houstonia magazine August 2015. 2016 Houston top doctors by Houstonia Magazine August 2016 2018 Houston top Doctors selected by their peers, Houstonia Magazine August 2018 2019 Elected member of the board of the American Autonomic Society 2019 Chairman of the pediatric committee at the American Autonomic Society.

EDITORIAL POSITIONS:

2002 till 2008 Reviewer for: Qatar Medical Journal

2003 till 2005 Reviewer for: Heart Views journal

2005 till current date Reviewer for: Cardiology in the Young Journal

2005 till current date Editorial board, The Journal of Tehran Heart Center 2012 Reviewer for: The Tohoko Journal of Experimental medicine. 2012 till current date: Reviewer for Pediatric Cardiology Journal 2014 Editorial board; Austin Journal of Pediatrics 2016

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Reviewer for Journal of Pediatrics 2016 Reviewer for Indian Heart Journal 2016 Reviewer for the American Journal of Cardiology 2017 Editorial board, Journal of Pediatrics and Pediatric Medicine 2017 Reviewer for Journal of Innovative Optical Health Sciences 2018 Editorial board member of Journal of Clinical Cardiology and Cardiac Therapy 2019 Reviewer for Clinical Neurology and Neurosurgery journal SERVICE ON THE UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON COMMITTEES:

September 2011- September 2016 Member, Faculty Compensation Committee The McGovern Medical School (Medical School) at the University of Texas Health Science Center Compensation Plan (Compensation Plan or Plan) is intended to promote the fair and effective compensation of its faculty and general administrative and professional staff (e.g., staff physicians) in order to maintain and enhance excellence towards the missions of education, research, and patient care of The University of Texas Health Science Center at Houston (UTHealth). The Medical School is committed to providing a competitive compensation package including salary, retirement, other benefits, and rewards for performance. The Plan provides a basis for establishing an annual salary and, if applicable, incentive compensation for Plan Participants. The Plan allows for salary increases in recognition of an individual's increased duties, accomplishments, and notable performance, as well as for salary reductions when duties, accomplishments, or performance fall below expectations. This Plan does not constitute a contract or grant any rights beyond which any person is already entitled. UTHealth and the Medical School reserve the right to modify or cancel this plan at any time with the approval of the President of UTHealth and of the Executive Vice Chancellor for Health Affairs of The University of Texas System (UT System)

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September 2012- August 2018 Member, Faculty Development Leave Committee The Texas legislature’s purpose in establishing the Faculty Development Leave Program is to improve further the higher education available to the youth at the state-supported colleges and universities and to establish this program of faculty development leaves as part of the plan of compensation for the faculty of these colleges and universities. The faculty development leave proposal should be designed to enable the faculty member to engage in study, research, writing, and similar projects for the purpose of adding to the knowledge and skills available to him/herself, to the students, to the institution, and society generally. “A faculty development leave of absence may be granted for study, research, writing, field observations, or other suitable purpose within the school’s mission, if the faculty member is eligible by reason of service, the purpose is one for which a faculty development leave may be granted, and the granting of such leave does not place on faculty development leave a greater number of faculty members than that authorized. It is intended that all faculty members have the right to have their proposals considered by a faculty peer review committee and that the proposals be forwarded through the entire review process

SERVICE ON UTMSH AFFILIATED HOSPITAL COMMITTEES: October 2009 - 2013: Hermann Hospital Committee for Quality Control and Improvement of Pediatric Cardiology and Cardiovascular Program. SPONSORSHIP OF POSTDOCTORAL FELLOWS: 2003-2007 Dr. Mahmoud AlSoufi: Pediatric Cardiology fellow 2009-2011 Dr. Georgios Hartas: Pediatric Cardiology Fellow 2009-2011 Dr. Emmanouil Tsounias: Pediatric cardiology Fellow 2009-2011 Dr. Srilatha Alapati: Pediatric Cardiology Fellow 2009-2012 Dr. Raj Sahu: Pediatric Cardiology Fellow 2009-2013 Dr. Ngozi Agu: Pediatric Cardiology Fellow 2010-2013 Dr. Henry Burkholder: Pediatric Cardiology Fellow 2010-2013 Dr. Tharakanatha Yarrabolu: Pediatric Cardiology Fellow 2011-2014 Dr. Arpan Doshi: Pediatric Cardiology fellow 2012-2015 Dr. Unnati Doshi: Pediatric Cardiology fellow 2012-2015 Dr. Maria C. Yates: Pediatric cardiology fellow 2012-2013 Dr. Claudeen Scott: Pediatric Cardiology fellow 2012-2015 Dr. Ashish Banker: Pediatric Cardiology fellow

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2012-2015 Dr. Yuliya Turiy: Pediatric cardiology fellow 2012-2013 Dr. Nazire Ozcelik: Pediatric Cardiology fellow 2013-2016 Dr. Liz Wang: Pediatric Cardiology fellow 2013-2016 Dr. Ankor Shah: Pediatric Cardiology fellow 2013-2016 Dr. Durga Naidu: Pediatric Cardiology fellow 2014-2017 Dr. Christina Dang: Pediatric Cardiology fellow 2014-2017 Dr. Jyoti Bhatia-Barnes: Pediatric Cardiology fellow 2014-2017 Dr. Andrea Harris: Pediatric Cardiology fellow 2014-2017 Dr. Frank Osei: Pediatric Cardiology fellow 2015-2018 Dr. Jenna Aldinger- Pediatric Cardiology fellow 2015-2018 Dr. Siddharth Dubey Pediatric Cardiology fellow 2015-2018 Dr. Geetha Radhakrishnan Pediatric Cardiology fellow 2016-2017 Dr. Bijoy Thattaliyath: Pediatric Cardiology fellow 2017-2018 Dr. Arpit Agarwal: Pediatric Cardiology fellow 2016 -2019 Dr. Lily Xiong: Pediatric Cardiology fellow 2016 -2019 Dr. Khalisa Syeda: Pediatric Cardiology fellow 2017 -2019 Dr. Dzmitry Matsiukevich: Pediatric Cardiology fellow 2017 Dr. Elisa Rhee: Pediatric Cardiology fellow 2018 Dr. Ahmed Mokhtar Deniwar: Pediatric Cardiology fellow 2018 Dr. Jannika Doge Khatami: Pediatric Cardiology fellow 2018 Dr. Sheba John: Pediatric Cardiology fellow TEACHING RESPONSIBILITIES:

Post Graduate Medical Education: Primary teaching effort is currently directed towards Pediatric Cardiology

fellows in training at the University of Texas/Hermann Children’s hospital. Shared in developing a curriculum in Pediatric cardiology, including informal discussions and didactic lectures (including: Action potential and cellular mechanisms of conduction, Trans Esophageal Electrophysiology studies, Principles of Pediatric EP testing and Tilt table testing) and emphasizing interpretive/analytical as well as manual skills.

Grand rounds to Pediatric faculty and residents at University of Texas/Hermann hospital: 1) Myocarditis and arrhythmia,. 2) Neuro-cardiogenic Syncope and Dysautonomia, 3) Syncope in the young, 4) Emergency Management of Pediatric Arrhythmia

Grand rounds and lectures to Adult Cardiology division at the University of

Texas: 1) Grand round: Arrhythmia in adult congenital heart patients, January

2010 2) Lecture: Anatomy of Conduction system in Congenital Hearts, April

2010

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3) Lecture: Tilt table testing for EP fellows: November 2009 4) Lecture: Junctional Ectopic Tachycardia for EP fellows May 2009 5) Lecture: Emergency treatment of Pediatric arrhythmia for EP fellows

April 2009. Lectures for Neonatology and Pediatric intensive care fellows at the

department of Pediatrics, University of Texas & Health Science center: 1) Fetal and Neonatal Arrhythmia, September 2009. 2) Development of Embryonic Conduction system and its abnormalities

(given in two sessions) July 2010.

Graduate Medical Education for medical students at the University of Texas: Involved in serial lectures given every year to the 3rd and 4th year medical students at the University of Texas. Total of six lectures given in year 2010 and five lectures given in year 2009 for several groups (about 35 students each group). These lectures include Acquired Heart diseases in children, Cyanotic congenital heart diseases and Acyanotic congenital heart diseases.

Major Clinical Responsibilities/Achievements and Interests:

1. Establish of Pediatric Dysautonomia Center at Memorial Hermann Children’s

Hospital/University of Texas: This center was initiated in collaborative work between Pediatric Cardiology, Pediatric Neurology, Pediatric Immunology, Pediatric Gastroenterology and general Pediatrics services. The Center was led by myself and Dr. Ian Butler. Since establishment in October 2011 we evaluated and managed more than 480 patients with the symptoms of Autonomic dysfunction. The evaluation process includes: Head up Tilt table testing with sympathetic/parasympathetic evaluation, brain perfusion using Near-infra red spectrograph, cardiac stroke volume, peripheral systemic resistance, upper and lower systemic muscle perfusion, brain imaging (MRI, CT scan, CSF pressure and neurotransmitters) myelogram for CSF leak and skin biopsy for small fiber-neuropathy. From this collaborative work we are presented twenty abstracts at the American Autonomic Society meeting during the period from October 2012 till November 2016, three abstracts in Carrell-Krusen Neuromuscular Symposium and one abstract at the American College of Cardiology meeting in March 2013 and one abstract to Heart Rhythm Society meeting 2014

2. Establish of Pediatric Electrophysiology unit in the Pediatric Cardiology division at the University of Texas, Houston health Science Center. This unit was formed by me in March 2009. Currently the volume of this unit is about 100 ablations per year with 650 non-invasive EP tests/year.

3. Establish of Electrophysiology services in the State of Qatar. For the first time in this country the EP service was established by me to provide Electrophysiology care for adults and Pediatric patients at the State of Qatar in

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November 2001. I was the director of this unit till March 2009. During these 8 years more than 500 interventional ablation procedures were performed on both adult and pediatric patients.

4. Congenital Heart interventional catheterization: Diagnostic hemodynamics and angiography Device closures of ASD, PDA, Peri membranous and muscular VSD,

Fenestrations and collaterals. Angioplasties and stent placements of pulmonary arteries, Aorta, Vena

cava and renal arteries. Trans septal punctures and atrial Septostomies Balloon aortic and pulmonary valvuloplasties

5. Cardiac Electrophysiology:

Noninvasive diagnostic procedures including Signal averaged ECG, Holter Monitoring, exercise testing, Tilt table test, Event monitors and T wave micro voltage.

Trans Esophageal Electrophysiology testing Implantation and management of Pace makers and ICD Implantation of Bi ventricular Resynchronization devices Performing invasive EP testing. Conducting ablative therapy using RF energy, Cryo ablation and cooled tip

ablation. Autonomic Tilt table testing. Including evaluation of cardiac Stroke volume,

Sympathetic/Parasympathetic tone, Heart rate and heart rate variability, Brain perfusion by Near Infra-Red Spectrography (NIRS) and beat to beat BP during several positions of the patient during the test.

6. Performing and interpretation of Congenital heart Echocardiography including fetal Echo, Intra Cardiac Echo (ICE) and 3- Dimensional Echo

Current Annual Clinical volume: Annual Clinic visits: 1100 visits (twice weekly half day clinic) Annual Invasive Procedures in the Cardiac catheterization Laboratory: 112 procedures. Annual Autonomic evaluations and Tilt table testing: 180 procedures Annual Non-invasive EP evaluation including Exercise test, Holter reporting, Event recorders, ECG’s, Pacemaker and ICD evaluations: 2100 tests Annual Echocardiography and Intracardiac Echo readings: 100 studies. CURRENT GRANT SUPPORT:

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Project title: Physiology of head up tilt in normal children and adolescents Primary investigators: Mohammed Numan and Anand Gourishankar Funding: University of Texas-Medical School Dean’s grant Award Period: October 2012 till present. Amount of Grant: $25000. Project Title: Post-Approval study of Amplatzer Muscular Ventricular Septal defect Occluder device. Primary Investigator at the University of Texas: Mohammed. T. Numan Funding Agency: AGA Medical Corporation. Award Period: April 2010 for 5 years Amount of the grant: $75000 PAST GRANT SUPPORT:

1. Co-investigator: Select Secure Medtronic lead Study for RV optimization, Grant from Medtronic Pacemaker Company. 2005

2. Co-investigator: Optimizing Cardiac Re Synchronization therapy using measured QRS duration. Grant by Guidant Pacemaker Company.

PUBLICATIONS: Published (peer reviewed) Abstracts in Medical Journals:

1) Numan MT, Blaufox A, Knick B, Saul JP. Effect of Respiration on intracardiac electrograms and radio-frequency ablation parameters

Cardiology in the Young, May2001, volume 11, page 54

2) Numan M T; Byrne B; Gelband C; Pachori A; Katovich M; Ganten D; Fenario C; Raizada M. Echocardiographic Evaluation of the TGR(mRen2)27 Transgenic Rat Reveals Severe Ventricular Hypertrophy and Pericardial Effusion. Pediatric research, April 1999- volume 45- Issue 4- p28A

3) Numan M T, Blaufox A, Knick B, Saul J P. Tip Cooling Techniques improve success for intra-atrial reentrant Tachycardia (IART) ablation. Cardiology in the Young, May2001, volume 11, page 72

4) Blaufox A, Numan M T, Knick B and Saul J P. Sino-atrial reentrant tachycardia; an under-recognized clinical entity in infants with congenital heart disease. Cardiology in the Young,May2001,volume 11page 52

5) Numan M T, Blaufox A, Knick B, Saul J P. Cardiac pathophysiology in a transgenic model of hypertension is due to elevated vascular resistance. Cardiology in the Young, May2001, volume 11, page 186

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6) Numan M T, Dilawar M, Elsaeed H, ElSisi A. Trans-Catheter Closure of Multi-Fenestrated Atrial Septal Defects: Comparison Study of HELEX vs. Cribriform Devices Journal of the American College of Cardiology. 2010;55(10s1):A182

7) Numan M T; Maposa D and Kantharia B K Supra Ventricular Tachycardia significantly reduces Stroke volume and causes minimal reduction of Cardiac output: study of Pediatric Patients Heart Rhythm Journal Vol 8, issue 11, 2011:1826-7

8) Numan M T, Lankford J E, Gourishankar A, Butler I J Cardiac Stroke Volume and sympathetic/parasympathetic measurements increase the sensitivity and specificity of HUTT in children and adolescents. Clinical Autonomic Research Journal, Vol 22,No. 5 p235. October 2012

9) Numan M T, Dilawar M, Balaguru D. Use of self-expandable stents in congenital heart disease in children and young adults; medium to long-term follow up Catheterization Cardiovascular Interventions, Vol 79, issue 5, April 2012; S13

10) Butler I J, Lankford J E, Numan M T. Biogenic amine metabolism in juvenile neuro-cardiogenic syncope with dysautonomia Clinical Autonomic Research Journal, Vol 22,No. 5 p236. October 2012

11) Lankford J E, Numan M T, Gourishankar A, Butler I J. Added Clinical value of cerebral blood flow in juveniles and young adults with neuro-cardiogenic syncope and dysautonomia as measured by near-infrared spectroscopy Clinical Autonomic Research Journal, Vol 22,No. 5 p241. October 2012

12) Memon N, Briceno D, Numan M T, Koenig M K, Kantharia B K. Electrophysiologic Manifestations of Mitochondrial Crisis. Heart Rhythm Journal, Vol 9, Issue11, Nov2012:1920-21.

13) Moody S, Belton M, Mancias P, Numan M T, Butler I J, Sheikh K. Small Fiber Neuropathy in Adolescents with Neuro-cardiogenic Syncope and Dysautomia Journal of Clinical Neuromuscular Disease, Vol 14, No. 3, p12. March 2013.

14) Numan M T, Alnajjar R, Butler I J. Cardiac Arrest Secondary to Severe Neuro-cardiogenic Syncope and Dysautonomia in Children and Adolescents during Head Up Tilt Test (HUTT). Journal of the American College of Cardiology,Vol 61,No.10(suppl A),March 2013.

15) Martinez R, Butler I J, Lankford J E, Numan M T. Dysautonomia in young adolescents and their families has a dominant inheritance pattern. Clinical Autonomic Research, Volume 23, Issue 5, p 244, October 2013.

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16) Numan M T, Pacheco S, Oler C, Martinez R and Butler I J. Does histamine have

a role as an immune-mediator in neuro-cardiogenic syncope and dysautonomia in young patients? Clinical Autonomic Research, Volume 23, Issue 5, p 267, October 2013.

17) Burkholder H, Hashmi S, Lankford J E, Butler I J, Numan M T. The correlation between increased variability of cardiovascular measures and premature termination of head up tilt table test in pediatric patients. Clinical Autonomic Research, Volume 23, Issue 5, p 267, October 2013.

18) Numan M T, Butler I J, Martinez R, Knight M, Memon N, Koenig M K. Mitochondrial insufficiency is associated with autonomic nervous system dysfunction as confirmed by physiologic head up tilt table test (HUTT). Clinical Autonomic Research, Volume 23, Issue 5, p 267, October 2013.

19) Memon N, Briceno D, Koenig M K, Kantharia B K and Numan M T. Prevalence and severity of autonomic dysfunction in patients with mitochondrial disorders: assessment by physiologic head up tilt table test. Heart Rhythm journal, Volume 11, Issue 5S, p S388. May 2014.

20) Srinivasan C, Moulik M and Numan M T. Use of Implantable cardioverter-defibrillator and sympathetic denervation for long QT syndrome in children and adolescents: a population-based study. Heart Rhythm journal, Volume 11, Issue 5S, p S407. May 2014.

21) Balaguru D, Rodriguez M, Wagner L, Beasley C, Leon S, Sultzer A, Numan M T. Use of Nanodot in children to measure radiation exposure during cardiac catheterization. Catheterization and Cardiovascular Interventions journal, Volume 83(Supplement 1):S144-S145. May 2014.

22) Martinez R, Butler IJ, Numan MT. The role of physical therapy in dysautonomia: Patient survey. Clinical Autonomic Research, Volume 24, Number 5 p226. October 2014.

23) Gourishankar A, Ali E, Lankford J, Butler IJ, Numan MT. Cerebral blood flow assessment for patients with convulsions during HUTT. Clinical Autonomic Research, Volume 24, Number 5 p221. October 2014.

24) Numan MT, Gourishankar A, Martinez R, Lankford J, Butler IJ. Cerebral blood flow measurement during HUTT: Clinical utility and implications for children and young adults. Clinical Autonomic Research, Volume 24, Number 5 p220. October 2014.

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25) Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Perfusion of Muscle Groups during HUTT in Patients with Dysautonomia. Journal of Clinical Neuromuscular Disease. Volume 16, Number 3. March 2015.

26) Pacheco SE, Butler IJ, Lankford J, Gourishankar A, Numan MT. Immunological abnormalities in young patients with dysautonomia. Autonomic Neuroscience: Basic&clinical journal. Volume 192- p21, November 2015.

27) Lankford J, Numan MT, Adejumo R, Martinez R, Von Allmen G, Koenig MK, Butler IJ. Vagal nerve stimulation in autonomic dysfunction- A case study. Autonomic Neuroscience: Basic&clinical journal. Volume 192- p83, November 2015.

28) Tran YX, Grant L, Numan MT, Butler IJ. Headaches in young adolescents with spontaneous intracranial hypotension and postural intolerance with dysautonomia: I cannot stand my headaches. Autonomic Neuroscience: Basic&clinical journal. Volume 192- p99, November 2015.

29) Gourishankar A, Butler IJ, Lankford J, Numan MT. Epidemiological characteristics of children and adolescents with positive head up tilt table test (HUTT). Autonomic Neuroscience: Basic&clinical journal. Volume 192- p102, November 2015.

30) Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Perfusion of muscle groups during HUTT in patients with dysautonomia. Autonomic Neuroscience: Basic&clinical journal. Volume 192- p118, November 2015.

31) Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Muscle and cerebral perfusion trends during HUTT in Pediatric and adolescent patients with dysautonomia. Autonomic Neuroscience: Basic&clinical journal. Volume 192- p119, November 2015.

32) Mary Kay Koenig, Ian J. Butler, Jeremy E. Lankford, Gretchen K. Von Allmen, Rahmat B. Adejumo, Rebecca E. Martinez, Mohammad T. Numan. Vagal nerve stimulation (VNS) as a novel therapy for autonomic dysfunction. Mitochondrion Journal, Volume 24, Supplement, September 2015, Page S37

33) Martinez R, Lankford J, Numan M, Butler I. Cytokine abnormalities in young patients with autonomic dysfunction. Clinical Autonomic Research journal. Volume 26, N5, p346. October 2016.

34) Alnoor M, Varner H, Butler I, Numan M. Baro-receptor sensitivity (BRS) in children and young adults: comparing normal controls to POTS (Postural

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orthostatic tachycardia syndrome) and Neurocardiogenic syncope patients. Clinical Autonomic Research journal. Volume 27, N5, p318. October 2017.

35) Elfadeel H, Varner H, Lankford J, Butler I, Numan M. Differential perfusion between the cerebral hemispheres depicted by near-infra red spectroscopy during head up tilt table test. Clinical Autonomic Research journal. Volume 27, N5, p324. October 2017

36) E.M. Smith, S.S. Hashmi, A. Gourishankar, M.T. Numan, I.J. Butler, J.E. Lankford. Comparison of cerebral oxygen saturation patterns in adolescents with autonomic dysfunction who experience syncope versus convulsive syncope during head up tilt testing. Clinical Autonomic Research journal, Volume 28, N5, p493. October 2018

37) Numan, MT, H. Varner, J.E. Lankford, I.J. Butler. Prevalence of convulsions in the pediatric population with orthostatic intolerance and neuro-cardiogenic syncope. Clinical Autonomic Research journal, Volume 28, N5, p494. October 2018

38) Numan, MT, Halawa, D, Butler, IJ, Zamil, H Gastrointestinal Symptoms and GI biomarkers in Postural orthostatic tachycardia syndrome and cardiogenic syncope in adolescents and young adults. Clinical Autonomic Research journal, Volume 29, N5, p524. October 2019.

Refereed Original Articles in Medical Journals:

1) Blaufox A, Numan M T, Laohakunakom P, Knick B and Saul J P. Tip Cooling

Techniques Improve Success for Intra-atrial Reentrant Tachycardia (IART) Ablation Pace, April 2001, volume 24 page 688-692

2) Blaufox AD, Numan M T, Knick BJ, Saul JP. Sinoatrial node reentrant tachycardia in infants with congenital heart disease. American Journal of Cardiology. 2001 Nov 1;88(9):1050-4.

3) Pachori AS, Numan MT, Ferrario CM, Diz DM, Raizada MK, Katovich MJ. Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy. Hypertension. 2002 May;39(5):969-75.

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4) Blaufox AD, Numan MT, Laohakunakorn P, Knick B, Paul T, Saul JP. Catheter tip cooling during radiofrequency ablation of intra-atrial reentry: effects on power, temperature, and impedance. J Cardiovasc Electrophysiol. 2002 Aug;13(8):783-7.

5) Al-Hroob A, Eltohami T, Gendi S, El Yemeni Y, Numan M T, Hijazi Z. Transcatheter Closure of Perimembranous and Muscular Ventricular Septal Defects in Children with the Amplatzer Occluder: Experience in Qatar. Heart Views Journal. 2003 June-August: 4(2) 66-72.

6) Salam AM, Azzam SB, Numan M, Haroob A, Musleh AW and Gehani AA. Updates in Pediatrics Basic Life Support: An Evidence-Based Review. Qatar Medical Journal 2003 Volume 12 (1):7-10.

7) Al Suwaidi J, Bener A, Suliman A, Hajar R, Salam AM, Numan M T, Al Binali HA. population based study of Ramadan fasting and acute coronary syndromes. Heart. 2004 Jun;90(6):695-6.

8) Al Suwaidi J, Bener A, Hajar HA, Numan MT. Does hospitalization for congestive heart failure occur more frequently in Ramadan: a population-based study (1991-2001). Int J Cardiol. 2004 Aug;96(2):217-21.

9) Ei-Menyar A, Ai-Hroob A, Numan MT, Gendi SM, Fawzy IM. Unilateral Pulmonary Edema: Unusual Presentation of Acute Rheumatic Fever. Pediat Cardiol journal.2005 Sep-Oct;26(5):700-2

10) El-Menyar A, Bener A, Numan MT, Morcos S, Taha R, Al Suwaidi J. Epidemiology of Idiopathic Cardiomyopathy in Qatar during 1996-2003. Med Princ Pract. 2006 Jan:15(1): 441-4

11) Ahmed B, Sisi A, Khenyab N, Saleh N, Mansoori Z, Gendi S, Said H, Numan M. Fetal Echocardiography Service in Qatar: Establishment, Challenges and Outcome. Qatar Medical Journal 2006 Volume 15 (1): 31-33.

12) El Sisi Amal, Numan M T. Stenting Disconnected LPA in 2 Kg baby with Fallot Tetralogy, pulmonary atresia 4 days post RBT shunt. Heart views, Vol 7, number 2, Jun- Aug 2006, 62-63.

13) El-Menyar A, Gendi S, Numan MT. Noncompaction Cardiomyopathy in the State of Qatar Saudi Med J Volume 28, March 2007: 89-93,

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14) El Sisi A, Dilawar M, Gendi S, Numan M T. Helex Septal Occluder: First Experience of Closure of Atrial Septal defect in Qatar Journal of the Saudi Heart Association. Vol 19, No 1.Jan 2007:36- 40

15) Numan M T, Ali S. Trans-catheter closure of large atrial septal defects in patients with Epstein’s malformation of the tricuspid valve: a report of two cases. Heart Views, 2007 volume 8, issue 3, page 109-111.

16) E.A.Eltohami, H.M.Ahmed, M.T.Numan, S.M.Gendi, A.Al Hroob. Epidemiology of Kawasaki disease in Qatar (An Arabian Gulf country). Qatar Medical Journal, 2007; 16(2):51-53

17) Koraichi N., Louon A. Nidal A.,Numan M. Brugada Syndrome and Anesthesia. Qatar Medical Journal. 2007;Volume 16 (2): 65-67.

18) El-Sisi AM, Gendi S, Dilawar M, Numan M T. Helex Septal Occluder: Feasibility Study of Closure of Atrial Septal Defect Pediatric Cardiology Journal. 2008 Jan;29(1):84-9

19) Dilawar M, Numan M T, El-Sisi A, Gendi SM, Ahmad Z. Percutaneous Closure of Ventricular Septal Defect Associated with Tunnel-Shaped Aneurysm Using the Amplatzer Duct Occluder, Pediatric Cardiology Journal. 2008 Mar; 29(2):366-70

20) Numan M T, El Sisi A, Tofeig M, Gendi S, Tohami T, El-Said HG. Cribriform Amplatzer Device Closure of Fenestrated Atrial Septal Defects: Feasibility and Technical Aspects Pediatric Cardiology Journal. 2008 May;29(3):530-5. Epub 2007 Nov 13

21) El-Sisi A, Khella A, Numan M T, Dilwar M, Bhat A, Soliman A. Linear Growth in Relation to the Circulating Concentration of Insulin-like Growth Factor-I and Free Thyroxine in Infants and Children with Congenital Cyanotic Heart Disease Before vs. After Surgical Intervention J Trop Pediatr. 2009 Oct;55(5):302-6.Epub ahead of print2009 Mar 1

22) Butler IJ, Lankford JE, Hashmi SS and Numan MT. Biogenic amine metabolism in juvenile neurocardiogenic syncope with dysautonomia. Annals of Clinical and translational Neurology, Volume 1, Issue 4, p 251-257. April 2014.

23) Numan MT, Alnajjar R, Lankford JE, Gourishankar A and Butler IJ. Cardiac asystole during head up tilt (HUTT) in children and adolescents: is this benign physiology? Pediatr Cardiol. 2014 Aug 3. [Epub ahead of print]. PMID: 25087055.

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24) Numan MT. Ibn Al Nafis: His Seminal Contributions to Cardiology. Pediatr Cardiol. 2014 Aug 6. [Epub ahead of print]. PMID: 25096906

25) Gautam NK, Rafique M and Numan T. Impact of isoproterenol infusion on BIS and metabolic values in pediatric patients undergoing electrophysiology studies. Journal of Clinical Anesthesia, Volume 26, Issue 7, December 2014. DOI: 10.1016/j.jclinane.2014.05.007

26) Lankford JE, Numan MT, Hashmi S, Gourishankar A, and Butler IJ. Cerebral Blood Flow Patterns in Juveniles and Young Adults with Dysautonomia are assessed with Respect to Symptom Severity and Stroke Volume. Clinical Autonomic Research Journal, 2015 Oct;25(5):277-84

27) Muhammed Riyas K Rahmath, Mohammed Numan and Muhammad Dilawar. Medium to long-term echo follow-up after ventricular septal defect device closure. Asian Cardiovascular & Thoracic Annals, 2016, Vol. 24(5) 422–427

28) Dilawar M, Riyas M, Rahmath K, Al-Hroob A, El-Said H G, El Sisi A, Gendi S, Numan MT. Low Incidence of Rhythm Disturbance Following Percutaneous Closure of Ventricular Septal Defects Using the Amplatzer Device at Immediate-to-Long-Term Follow Up. Journal of Structural Heart Disease, February 2016, Vol. 2(1) 35-41.

29) Posey JE, Martinez R, Lankford JE, Lupski J, Numan MT, Butler IJ. Dominant Transmission Observed in Adolescents and Families with Orthostatic Intolerance. Pediatric Neurology Journal. January 2017; 66:53-58.e5.

30) Numan MT, Kamdar A, Young J, Butler IJ. Autologous Adipose Stem Cell Therapy for Autonomic Nervous System Dysfunction in Two Young Patients. Stem Cells Development journal. March 2017, 5; 26(6):391-393.

31) Duraisamy Balaguru, Matthew Rodriguez1, Stephanie Leon2, Louis K Wagner2, Charles W Beasley2, Andrew Sultzer, Mohammed T Numan. Comparison of skin dose measurement using nanoDot® dosimeter and machine readings of radiation dose during cardiac catheterization in children.

Ann Pediatr Cardiol. 2018 Jan-Apr; 11(1): 12–16.

32) The Pediatric Writing Group of the American Autonomic Society Julian M. Stewart, Jeffrey R. Boris, Gisela Chelimsky, Phillip R. Fischer, John E. Fortunato, Blair P. Grubb, Geoffrey L. Heyer, Imad T. Jarjour, Marvin S. Medow, Mohammed T. Numan, Paolo T. Pianosi, Wolfgang Singer, Sally Tarbell, Thomas C. Chelimsky. Pediatric Disorders of Orthostatic Intolerance. PEDIATRCS, 2017 Dec 8. pii: e20171673. doi: 10.1542/peds.2017-1673. [Epub ahead of print]

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33) Mohammed T Numan, Howaida El-Said, Muhammed Dilawar and Amal El Sisi. The Challenge of Fenestrated Atrial Septal Defects closure; which device to choose? Journal of Cardiovascular Disorders and Medicine. Volume 3(5): 1-4, 2018. doi:10.15761/CDM.1000180

34) Mohammad S. Alnoor, Holly K. Varner, Ian J. Butler, Liang Zhu and Mohammed T. Numan. Baroreceptor activity and sensitivity: normal values in children and young adults using the head up tilt test. Pediatric Research Journal. 2019 May;85(6):841-847. doi: 10.1038/s41390-019-0327-6. Epub 2019 Feb 6.

35) Anand Gourishankar, Mathew D. Belton, S. Shahrukh Hashmi, Ian J. Butler, Jeremy E. Lankford, Mohammed T. Numan. Demographic and clinical features of pediatric patients with orthostatic intolerance and an abnormal head-up tilt table test; A retrospective descriptive study. Pediatrics & Neonatology Journal, 2019 Jul 5. pii: S1875-9572(18)30713-7. doi: 10.1016/j.pedneo.2019.06.012. [Epub ahead of print

Books & Chapters:

1) Atrial Septal Defects. Edited by Dr. Syam Rao. ISBN 978-953-51-0531- Chapter: Atrial Septal Defects/Patent Foramen Ovale and Migraine Headaches. Mohammed. T. Numan, MD

2) Perinatal Cardiology. Edited by Dr. Syam Rao. Chapter 16: Neonatal Rhythm and Dysrhythmias. By Mohammed. T. Numan Perinatal Cardiology: A Multidisciplinary Approach, Ed. Rao, P.S., Vidhyasagar, D. Cardiotext Publishing, Minneapolis, MN. (eISBN 9781 9353 95935)Feb 2015.

Abstracts and Posters Presented at National and International Conferences: 1) Numan M T; Byrne B; Gelband C; Pachori A; Katovich M; Ganten D; Fenario C; Raizada M. Echocardiographic Evaluation of the TGR(mRen2)27 Transgenic Rat Reveals Severe Ventricular Hypertrophy and Pericardial Effusion The American Pediatric Society and The Society for Pediatric Research 68th Annual Scientific sessions. May 1-4,1999. San Francisco, California. 2) Numan M T; Byrne B; Gelband C; Pachori A; Katovich M; Ganten D; Fenario C; Raizada M Cardiac Pathophysiology in a transgenic model of hypetension due to Elevated vascular impedance Southeastern Pediatric Cardiology Society Annual meeting September 21-23, 2000. Charlotte, North Carolina. 3) Blaufox A, Numan M T, Knick B and Saul JP Sino-atrial reentrant tachycardia; an under-recognized clinical entity in infants with congenital heart disease

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3rd World Congress of Pediatric Cardiology and Cardiac surgery. May 27-31, 2001. Toronto, Canada 4) Numan M T, Blaufox A, Knick B, Saul JP Cooled tip catheter improved the outcome of Radio-Frequency ablation of intra-atrial reentrant tachycardia 3rd World Congress of Pediatric Cardiology and Cardiac surgery. May 27-31, 2001. Toronto, Canada 5) Numan M T; Byrne B; Gelband C; Pachori A; Katovich M; Ganten D; Fenario C; Raizada M Echocardiographic Evaluation of the TGR(mRen2)27 Transgenic Rat Reveals Severe Ventricular Hypertrophy and Pericardial Effusion: 3rd World Congress of Pediatric Cardiology and Cardiac surgery. May 27-31, 2001. Toronto, Canada 6) Numan M T, Blaufox A, Knick B, Saul JP Respiration Effect on catheter stability during RF ablation 3rd World Congress of Pediatric Cardiology and Cardiac surgery. May 27-31, 2001. Toronto, Canada. 7) Numan MT, Blaufox A, Knick B, Saul JP Tip Cooling Techniques Improve Success for Intra-atrial Reentrant Tachycardia (lART) Ablation North America Society of Pacing and Electrophysiology 22nd Annual Scientific session May 2-5, 2001. Boston, Massachusetts. 8) Tsanios E, Numan MT, Gupta M and Tsai F Cor Triatriatum sinister with persistent left superior vena cava and dilated coronary sinus: A novel management approach 5th World Congress of Pediatric Cardiology and Cardiac Surgery. June 21st – 25th 2009. Cairns, Australia. 9) Numan M T, Mahmoud S Cryo ablation of congenital Junctional Ectopic Tachycardia with medium term follow up 5th World Congress of Pediatric Cardiology and Cardiac Surgery. June 21st – 25th 2009. Cairns, Australia. 10) Numan M T, Dilawar M, Elsaeed H, ElSisi A Trans-Catheter Closure of Multi-Fenestrated Atrial Septal Defects: Comparison study of Helex vs Cribriform Devices American College of Cardiology 59th Annual summit March 14th- 16th 2010. Atlanta, Georgia. 11) Ho T, Kantharia B, Dougherty A and Numan M T Cryo- ablation In Congenital Junctional Ectopic Tachycardia; Acute Efficacy And Safety Profile, And Long-term Clinical Outcome;

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Heart Rhythm Society 31st Annual scientific sessions May 12th – 15th 2010. Denver, Colorado. 12) Numan M T, Kantharia B Supra Ventricular Tachycardia significantly reduces Stroke volume and causes minimal reduction of Cardiac output: study of Pediatric Patients Cardiac Electrophysiology Society Annual meeting. November 12, 2011. Orlando, Florida. 13) Numan M T, Dilawar M and Balaguru D Use of Self-Expandable stents in Congenital Heart Diseases in children and Adults, Medium to Long-term follow up. Pediatric & Adult interventional cardiac symposium (PICS/AICS 2012) April 15-18, 2012. Chicago, IL. 14) Lankford J E, Numan M T, Gourishankar A, Butler I J Added Clinical Value of Cerebral Blood Flow in Juveniles and Young Adults with Neuro-cardiogenic Syncope and Dysautonomia as Measured by Near-infrared Spectroscopy 23rd INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM. Nassau, Bahamas October 2012. 15) Butler I J, Lankford J E, Numan M T. Biogenic amine metabolism in juvenile Neuro-cardiogenic syncope with dysautonomia. 23rd INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM. Nassau, Bahamas October 2012. 16) Numan M T, Lankford J E, Gourishankar A, Butler I J. Cardiac stroke volume and sympathetic/parasympathetic measurements increase the sensitivity and specificity of HUTT in children and adolescents 23rd INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM. Nassau, Bahamas October 2012. 17) Memon N, Briceno N, Numan M T, Koenig M K, Kantharia B K. Electrophysiologic Manifestations of Mitochondrial Crisis. Cardiac Electrophysiology Society Annual meeting. Los Angeles 3rd November 2012. 18) Burkholder H, Biliciler-Denktas G and Numan M T. The Amazing Right Bundle Branch Block—A Vanishing Act Witnessed in Motion. 6th World Congress of Pediatric Cardiology and Cardiac Surgery. Cape Town, South Africa 17-22 February 2013. 19) Numan M T, Yarrabolu T and Biliciler-Denktas G. Sinus Node dysfunction due to Myocarditis. 6th World Congress of Pediatric Cardiology and Cardiac Surgery. Cape Town, South Africa 17-22 February 2013

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20) Barreto A D, Doan D T, Fulep E, Bui T, Burkholder H, Bulter I J, Numan M T Comparison of Transcranial Doppler Ultrasound with Intracardiac Echocardiography in the Detection of Cardiac Right to Left Shunt in Children and Young Adults International Stroke Conference, Hawaii- January 2013 21) Moody S Belton M , Mancias P, Butler I J, Numan M T, Sheikh K. Small Fiber Neuropathy (SNF) in Adolescents with Neurocardiogenic Syncope and Dysautonomia. 35th Annual Carrell-Krusen Neuromuscular Symposium, Dallas, TX- 2/14/2013 22) Barreto A D, Doan D, Fulep E, Bui T, Burkholder H, Butler I J, Numan M T Correlation of Atrial Septal Defect Size as Measured by Intracardiac Echocardiography and Transcranial Doppler Ultrasound in Children and Young Adults. American Academy of Neurology 65th Annual Meeting, San Diego, CA- 3/16/2013 23) Numan M T, Alnajjar R, Butler I J. Cardiac Arrest Secondary to Severe Neuro-cardiogenic Syncope And Dysautonomia In Children And Adolescents During Head Up Tilt Test (HUTT). American College of Cardiology 2013 Annual meeting, San Francisco 9-13th March. 24) Gautam N K, Rafique M and Numan M T Impact Of Isoproterenol Infusion On BIS Values In Pediatric Patients Undergoing EP Studies. 25th SPA/AAP Pediatric Anesthesiology 2013. Las Vegas March 14-17th 2013. 25) Numan M T, Butler I J, Martinez R, Knight M, Memon N and Koenig M K. Mitochondrial insufficiency is associated with Autonomic nervous system dysfunction as confirmed by physiologic Head up Tilt table test (HUTT). Mitochondrial Medicine annual meeting June 12-15. Newport, California. 26) Lankford JE, Burkholder H, Butler IJ, Hashmi SS and Numan MT. The correlation between increased variability of cardiovascular measures and premature discontinuation of head up tilt table test in pediatric patients. American Autonomic Society/ 24th International Symposium on the Autonomic Nervous System. Kohala Coast, the Big Island, Hawaii, October 23-26, 2013 27) Numan M T, Butler I J, Martinez R and Pacheco S. Does Histamine have a role as immune-modulator in neuro-cardiogenic syncope and dysautonomia in young population? American Autonomic Society/ 24th International Symposium on the Autonomic Nervous System. Kohala Coast, the Big Island, Hawaii, October 23-26, 2013 28) Martinez R, Butler I J, Lankford JE, Numan M T. Dysautonomia in young adolescents and their families has a dominant inheritance pattern. American Autonomic Society/ 24th International Symposium on the Autonomic Nervous System. Kohala Coast, the Big Island, Hawaii, October 23-26, 2013

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29) Srinivasan C, Moulik M and Numan M T. Use of Implantable cardioverter-defibrillator and sympathetic denervation for long QT syndrome in children and adolescents: a population-based study. Heart Rhythm Society 35th Annual meeting, San Francisco May 7-10, 2014. 30) Memon N, Briceno D, Koenig M K, Kantharia B K and Numan M T. Prevalence and severity of autonomic dysfunction in patients with mitochondrial disorders: assessment by physiologic head up tilt table test. Heart Rhythm Society 35th Annual meeting, San Francisco May 7-10, 2014. 31) Balaguru D, Rodriguez M, Wagner L, Beasley C, Leon S, Sultzer A, Numan MT. Use of Nanodot in children to measure radiation exposure during cardiac catheterization. The Society for Cardiovascular Angiography and Interventions 2014 scientific sessions. Las Vegas May 28-31, 2014. 32) Martinez R, Butler IJ, Numan MT. The role of physical therapy in dysautonomia: Patient survey. American Autonomic Society/ 25th International Symposium on the Autonomic Nervous System. Rio Grande, Puerto Rico. November 5-8 2014. 33) Gourishankar A, Ali E, Lankford J, Butler IJ, Numan MT. Cerebral blood flow assessment for patients with convulsions during HUTT American Autonomic Society/ 25th International Symposium on the Autonomic Nervous System. Rio Grande, Puerto Rico. November 5-8 2014. 34) Numan MT, Gourishankar A, Martinez R, Lankford J, Butler IJ. Cerebral blood flow measurement during HUTT: Clinical utility and implications for children and young adults. American Autonomic Society/ 25th International Symposium on the Autonomic Nervous System. Rio Grande, Puerto Rico. November 5-8 2014. 35) Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Perfusion of Muscle Groups during HUTT in Patients with Dysautonomia. 37th Annual Carrell-Krusen Neuromuscular Symposium, Dallas February 19-20th 2015. 36) Pacheco SE, Butler IJ, Lankford J, Gourishankar A, Numan MT. Immunological abnormalities in young patients with dysautonomia 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy. 26th-29th September 2015. 37) Lankford J, Numan MT, Adejumo R, Martinez R, Von Allmen G, Koenig MK, Butler IJ. Vagal nerve stimulation in autonomic dysfunction- A case study

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9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy. 26th-29th September 2015. 38) Tran YX, Grant L, Numan MT, Butler IJ. Headaches in young adolescents with spontaneous intracranial hypotension and postural intolerance with dysautonomia: I cannot stand my headaches. 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy. 26th-29th September 2015. 39) Gourishankar A, Butler IJ, Lankford J, Numan MT. Epidemiological characteristics of children and adolescents with positive head up tilt table test (HUTT). 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy. 26th-29th September 2015. 40) Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Perfusion of muscle groups during HUTT in patients with dysautonomia. 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy. 26th-29th September 2015. 41) Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Muscle and cerebral perfusion trends during HUTT in Pediatric and adolescent patients with dysautonomia. Pabst L, Tran Y, Hashmi S, Butler IJ, Numan MT. Muscle and cerebral perfusion trends during HUTT in Pediatric and adolescent patients with dysautonomia. 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy. 26th-29th September 2015. 42) Martinez R, Lankford, JE, Butler IJ, Numan, MT. Cytokines and auto-immune disorders in patients with dysautonomia. The 27th Annual meeting of the American Autonomic Society November 1st- 4th, 2016, San Diego. 43) Alnoor M, Varner H, Butler I, Numan M. Baro-receptor sensitivity (BRS) in children and young adults: comparing normal controls to POTS (Postural orthostatic tachycardia syndrome) and Neurocardiogenic syncope patients. The 28th International Symposium of the Autonomic Nervous System. Annual meeting of the American Autonomic Society, November 1-4, 2017, Clearwater Beach, Florida.

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44) Elfadeel H, Varner H, Lankford J, Butler I, Numan M. Differential perfusion between the cerebral hemispheres depicted by near-infra red spectroscopy during head up tilt table test. The 28th International Symposium of the Autonomic Nervous System. Annual meeting of the American Autonomic Society, November 1-4, 2017, Clearwater Beach, Florida. 45) Numan, MT, Butler IJ, Barreto A. Comparison of intracardiac echocardiography and trans-cranial Doppler ultrasound in detecting cardiac right to left shunt. The 21st PICS-AICS Symposium, September 5-8, 2018. Las Vegas, Nevada 46) E.M. Smith, S.S. Hashmi, A. Gourishankar, M.T. Numan, I.J. Butler, J.E. Lankford. Comparison of cerebral oxygen saturation patterns in adolescents with autonomic dysfunction who experience syncope versus convulsive syncope during head up tilt testing. 29TH INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM Newport Beach Marriott Newport Beach, California October 24-27, 2018 47) Numan, MT, H. Varner, J.E. Lankford, I.J. Butler. Prevalence of convulsions in the pediatric population with orthostatic intolerance and neuro-cardiogenic syncope. 29TH INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM Newport Beach Marriott Newport Beach, California October 24-27, 2018 48) Numan, MT, Halawa, D, Butler, IJ, Zamil, H. Gastrointestinal Symptoms and GI biomarkers in Postural orthostatic tachycardia syndrome and cardiogenic syncope in adolescents and young adults. 30th International Symposium on Autonomic Nervous system, Clearwater, Florida, November 6-9, 2019. Invited Speaker to give the following lectures: Lectures and presentations in International meetings:

1. Trans Catheter device closure of Membranous Ventricular Septal Defects - a new Method. Lecture in the 11th Conference of the Union of Arab Pediatric Societies, Bahrain, 2-5 December 2003.

2. Intra atrial reentrant tachycardia, A rising problem in young adults. Lecture in

King Faisal specialist hospital Symposium of Electrophysiology in the young, 23-25 March 2004, Saudi Arabia.

3. Self- Expandable Stents in Children. Presentation in Gulf Heart Association 2nd

meeting, 13-15 January 2004, Oman

4. Ablation of life threatening Arrhythmia. Lecture in Gulf Heart Association 2nd meeting 13-15 January 2004, Oman

5. Trans Catheter device closure of Membranous Ventricular Septal Defects.

Lecture in Gulf Heart Association 2nd meeting 13-15 January 2004, Oman

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6. New interventional cardiac catheterizations in children. Lecture given in Tahran

16th International Pediatric Congress 8-13 October 2004, Iran. 7. New Methods to Determine the Cardiac output. Lecture given in Libyan Heart

society day, Bengazi 19th May 2005, Libya.

8. Cryo Ablation of Atrial Fibrillation. Presentation in Cairo Atrial Fib Alliance meeting, October 2004, Egypt.

9. Management of Pediatric Arrhythmia in Emergency room. Lecture given in

Pediatric Emergency Symposium, April 2003, Qatar.

10. Neurological Sequelae of Congenital heart disease. Lecture in Pediatric Neurology Symposium, March 2004, Qatar.

11. “Difficult case” presentation of congenital JET ablation. Presented in 3rd

Charleston EP Symposium, 1-3 May 2005. Charleston, South Carolina.

12. Trans- catheter intervention workshop 15-23 April 2006 in Sudan Heart center, Khartoum, Sudan.

13. “Acute Management of Pediatric Arrhythmia in Emergency room”. Fourth

Annual Pediatric cardiology Symposium for the Primary care Physician. Herman Hospital. University of Texas. Houston Texas. 26th October 2007

14. “Palpitation: what to do next” Fifth Annual Pediatric cardiology Symposium for

the Primary care Physician. Hermann Children’s hospital/University of Texas. October 2009.

15. “Benign Arrhythmias in Infancy and Childhood” Sixth Annual Pediatric

cardiology Symposium for the Primary care Physician. Hermann Children’s hospital/University of Texas. October 29th 2010.

16. “Advanced Management of Arrhythmias in infancy and childhood”. 7th Annual

Pediatric Cardiology Symposium for the primary care physicians. Hermann Children’s Hospital/ University of Texas. October 14th 2011. Houston, Texas.

17. Invited Professor for The University of Jordan, Amman, Jordan

To give two grand rounds about Pediatric Arrhythmia and a workshop for Pediatric residents about “rhythm and Arrhythmia in children” June 25th till July 2nd 2012.

18. Invited speaker for Dysautonomai International annual meeting in Washington DC, July 19th till 20th 2015.

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19. Invited speaker “Chase lecture” at Texas A&M college of Medicine, College Station, Texas. January 2015

20. Invited speaker United Mitochondrial Disease Foundation (UMDF) Central Regional Mitochondrial Medicine Symposium at the Hotel Zaza and Children’s Memorial Hermann Hospital, Houston, TX on February 12, 2016

21. Invited visiting professor to the University of Jordan, Amman Jordan, May 10th till 12th 2016.

22. Invited speaker, 11th Annual Pediatric Cardiology Symposium for primary care providers. Houston, Texas on November 12th 2016.

23. Invited speaker by Texas A&M medical school, College Station, Texas. Sarah Elizabeth Truit Chase Lectureship – Dysautonomia. January 2017.

24. Invited speaker by Virginia Commonwealth University, Department of Pediatrics, Richmond, Virginia. Syncope and Autonomic nervous system dysfunction in the young. Pediatric Grand rounds. December 7th 2017.

25. Invited speaker for Grand rounds in Internal Medicine-Neurology department at The University of Texas Health Science Center at Houston, McGovern Medical School. March 9th 2018. “Dysautonomia in the young”.

26. Speaker, Grand rounds of Pediatrics department. McGovern Medical School at The University of Texas Health Science Center, Houston. October 2nd 2018. “Genetic Channelopathies in the young”.

27. Invited speaker, American Autonomic society 30th annual meeting. Clearwater, Florida. Syncope in the young: what do we know about their physiology so far?. November 10th, 2019.

Organization of Conferences and Workshops:

1. 1st Qatar Fetal Cardiology Symposium. April 2007. Doha, Qatar Chairman of the Symposium and the Head of Scientific Committee.

2. Member of the scientific committee for 1st Gulf Heart Association meetin January 2002. Doha, Qatar

3. Member of the scientific committee for the 3rd Qatar International Pediatric Symposium. April 2005. Doha, Qatar.

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4. Co- Chair Pediatric Electrophysiology session, The 1st Middle East Symposium in Pediatric Cardiology- Surgery, May 2004. Beirut, Lebanon.

5. Co- Chair Pediatric Cardiology session, the 3rd Qatar International Pediatric Symposium. April 2005. Doha, Qatar.

6. Director of Pace maker basics workshop, held June 2005. Sponsored by Guidant Company, Doha, Qatar.

7. Workshop for Helex ASD device closure at HMC, Qatar. The first center in the Middle East to perform such a procedure, 10th and 11th December 2005. Till present time we performed 11 cases with Helex ASD device closure.

8. Chairman of Symposium “Principles of Fetal Echocardiography: Methods and Principles” April 26&27 2007. Doha,Qatar

9. Mentor of “Helex device closure of ASD” workshop in Al Qasmi Hospital. Sharjah UAE June 2007.

10. Mentor of “Helex device closure of ASD” workshop in Chest hospital, Kuwait. February 2007

11. Mentor of Helex device closure of ASD” workshop in National Guard hospital Riyadh, Saudi Arabia. March 2007.

12. Head of Mission of “Trans-catheter Therapy for congenital Heart diseases” in Damascuss ,Syria. August 2007

13. Director of Mission “ Trans-catheter Therapy for congenital Heart diseases” Ibn Rushd Hospital, Casablanca, Morocco. July 2010

14. Director of Mission “ Trans-catheter Therapy for congenital Heart diseases” Sheikh Zayed Hospital, Nouakchott, Mauritania July 2011.

15. Co-Director, “Dysautonomia Symposium”. Memorial Hermann Children’s Hospital, Houston, Texas. April 2015.

16. Co-Director, “Dysautonomia Symposium”, Cooley Conference Center, Houston, Texas. April 30th 2016.

17. Invited speaker for “Autonomic Disorders Workshop for generalists” Milwakee, Wisconsin. May 21st 2016.

18. Co-Director, “Dysautonomia Symposium”, Cooley conference center, Houston, Texas. March 4th 2017.