Generic Name Trade Name Designated Indication Marketing Approved Indication Designated Date Market Exculsivity Date

Vaccinia Immune Globulin (Human) Intravenous CNJ-016 Treatment of complications of vaccinia vaccination

treatment and/or modification of the following conditions, which are complications resulting from smallpox vaccination: Eczema vaccinatum 18.06.2004 01.05.9999

Antihemophilic factor (recombinant) ReFacto

For the control and prevention of hemorrhagic episodes and for surgical prophylaxis in patients with hemophilia A (congenital factor VIII deficiency or classic hemophilia). 08.02.1996 01.01.9999

Potassium Iodide Oral Solution ThyroShield

For use as a thyroid blocking agent in pediatric patients exposed to radiactive iodine

For use as a thyroid blocking agent in pediatric patients exposed to radiactive iodine 17.11.2004 01.01.9999

Pulmonary surfactant replacement, porcine Curosurf

For the treatment and prevention of respiratory distress syndrome in premature infants.

Treatment (rescue) of respiratory distress syndrome in premature infants. 02.08.1993 01.01.9999

Somatropin (rDNA origin) Saizen

Treatment of idiopathic or organic growth hormone deficiency in children with growth failure.

Long term treatment of children with growth failure due to inadequate secretion of endogenous growth hormone. 06.03.1987 01.01.9999

Somatropin (rDNA origin) Nutropin Depot

Long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.

Long-term treatment of growth failure due to a lack of adequate endogenous growth hormone secetion for once- or twice-a-month administration. 28.10.1999 01.01.9999

Somatropin (rDNA origin) injection Norditropin

Treatment of growth failure in children due to inadequate growth hormone secretion.

have growth failure due to inadequate secretion of endogenous growth 10.07.1987 01.01.9999

Surface active extract of saline lavage of bovine lungs Infasurf

Treatment and prevention of respiratory failure due to pulmonary surfactant deficiency in preterm infants.

Treatment and prevention of respiratory failure due to pulmonary surfactant deficiency in preterm infants. 07.06.1985 01.01.9999

Trypan blue MembraneBlue

Selectively staining epiretinal membranes during ophthalmic surgical victrectomy procedures

For use as an aid in ophthalmic surgery by staining the epiretinal membranes during ophthalmic surgical vitrectomy procedures, 02.08.2006 20.02.2009

Recombinant human antithrombin ATryn

Treatment of congenital antithrombin deficiency to prevent the occurrence of serious, potentially life-threatening venous thromboembolisms which may develop as a result of surgical or obstetrical procedures

Prevention of peri-operative and peri-partum thromboembolic events, in hereditary antithrombin deficient patients. 07.12.2007 06.02.2009

human fibrinogen concentrate, pasteurized RiaSTAP Treatment of fibrinogen deficient patients

Treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency (afibrinogenemia and hypofibrinogenemia 13.03.2008 16.01.2009

Fludarabine phosphate oral tablets Treatment of B-cell chronic lymphocytic leukemia

Treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) whose disease has not responded to or has progressed during or after 18.12.2007 18.12.2008

plerixafor Mozobil

For use to improve the yield of progentor cells in the apheresis product for subsequest stem cell transplantation following myelosuppressive or myeloablative chemotherapy

To enhance mobilization of hematopoietic stem cells to the peripheral blood for collection and subsequent autologous 10.07.2003 15.12.2008

eltrombopag Promacta Treatment of idiopathic thrombocytopenia purpura

Treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura 05.05.2008 20.11.2008

Cumulative List of all Products that have received Orphan Designation: Total active designations: 2002 Effecive: 5/5/2009

rufinamide Banzel Treatment of Lennox-Gastaut Syndrome.

Adjunctive therapy of seizures associated with Lennox-Gastaut syndrome. 08.10.2004 14.11.2008

C1 esterase inhibitor (human) Cinryze Treatment of angioedema

Routine prophylaxis against angioedema attacks in patients with Hereditary Angioedema (HAE) 16.07.2004 10.10.2008

Iobenguane I 123 AdreView For the diagnosis of pheochromocytomas

To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other diagnostic tests 01.12.2006 19.09.2008

Iobenguane I 123 Adreview For the diagnosis of neuroblastomas

To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other diagnostic tests 01.12.2006 19.09.2008

Immune Globulin (Human) Gamunex

Treatment of chronic inflammatory demyelinating polyneuropathy

Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) to improve neuromuscular disability and impairment and for maintenance therapy to prevent relapse 27.07.2004 12.09.2008

romiplstim Nplate Treatment of immune thrombocytopenic purpura

Treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient 27.03.2003 22.08.2008

Tetrabenazine Xenazine Treatment of Huntington's diseaseTreatment of chorea associated with Huntington's disease 11.12.1997 15.08.2008

Sorafenib Nexavar Treatment of hepatocellular carcinomaTreatment of unresectable hepatocellular carcinoma 20.04.2006 24.03.2008

Bendamustine hydrochloride Treanda Treatment of chronic lymphocytic leukemiaTreatment of patients with chronic lymphocytic leukemia 17.08.2007 20.03.2008

LevoleucovorinFor use in conjunction with high-dose methotrexate in the treatment of osteosarcoma.

Levoleucovorin rescue is indicated after high-dose methotrexate therapy in osteosarcoma. Levoleucovorin is also indicated to diminish the toxicity 01.08.1991 07.03.2008

Rilonacept Arcalyst Treatment of CIAS1-Associated Periodic SyndromesTreatment of Cryopyrin-Assisted Periodic Syndromes (CAPS) 20.12.2004 27.02.2008

Adalimumab Humira Treatment of juvenile rheumatoid arthritisTreatment of Juvenile Idiopathic Arthritis 21.03.2005 21.02.2008

Thyrotropin alfa Thyrogen

Treatment of well-differentiated papillary, follicular or combined papillary/follicular carcinomas of the thyroid

For use as an adjunctive treatment for radioiodine ablation of thyroid tissue remnants in patients who have undergone thyroidectomy for well- 03.08.2001 14.12.2007

sapropterin Kuvan Treatment of hyperphenylalaninemia

Indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) 29.01.2004 13.12.2007

Nilotinib Tasigna Treatment of chronic myelogenous leukemia

For the use for chronic phase (CP) and accelerated phase (AP) Philadelphia chromosome positive chronic myelogenous leukemia (CML) 27.04.2006 29.10.2007

Raloxifene Evista

Reduction of the risk of breast cancer in postmenopausal women

Reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and reduction in risk of invasive breast cancer in 14.07.2005 13.09.2007

dexrazoxane Totect

Treatment of anthracycline extravasation during chemotherapy

Treatment of extravasation resulting from IV anthracycline chemotherapy 25.03.2004 06.09.2007

Lanreotide Somatuline Depot Treatment for acromegly

Long-term treatment of acromegalic patients who have had an inadequate response to or cannot be treated with surgery and/or radiotherapy 11.09.2000 30.08.2007

ambrisentan Letairis Treatment of pulmonary arterial hypertension

Treatment of pulmonary arterial hypertension (WHO group I) in patients with WHO class II or III symptoms to improve exercise 16.07.2004 15.06.2007

Somatropin Norditropin

Treatment of short stature in patients with Noonan syndrome

Treatment of short stature in patients with Noonan syndrome 09.08.2006 31.05.2007

Temsirolimus Torisel Treatment of renal cell carcinomaTreatment of advanced renal cell carcinoma 16.12.2004 30.05.2007

Doxorubicin HCL liposome injection Doxil Treatment of multiple myeloma

For use in combination with bortezomib for the treatment of patients with multiple myeloma who have not previously received 29.12.2004 17.05.2007

Histrelin Supprelin LA Treatment of central precocious pubertyTreatment of central precocious puberty 18.11.2005 03.05.2007

hepatitis B immune globulin (human) HepaGam

Prevention of hepatitis B recurrence following orthotopic liver transplant

Prevention of hepatitis B recurrence following liver transplantation in HBsAG-positive liver transplant patients 24.03.2008 06.04.2007

Protein C concentrate Ceprotin

For replacement therapy in congenital protein C deficiency for the prevention and treatment of thrombosis, pulmonary emboli, and purpura fulminans.

Prevention and treatment of venous thrombosis and purpura fulminans 23.06.1992 30.03.2007

eculizumab Soliris Treatment of paroxysmal nocturnal hemoglobinuriaTreatment of paroxysmal nocturnal hemoglobinuria to reduce hemolysis 20.08.2003 16.03.2007

Antihemophilic factor (human) Alphanate Treatment of von Willebrand's disease

For surgical and/or invasive procedures in patients with von Willebrand Disease (VWD) in whom desmopressin is either ineffective or 05.01.1996 31.01.2007

Balsalazide disodium Colazal Treatment of pediatric patients with ulcerative colitis

Treatment of mildly to moderately active ulcerative colitis in patients 5 years of age and older. Safety and Effectiveness of Colazal beyond 8 12.08.2005 20.12.2006

Hydroxocobalamin Cyanokit Treatment of acute cyanide poisoningTreatment on known or suspected cyanide poisoning 25.11.2003 15.12.2006

Imatinib mesylate Gleevec

Treatment of systemic mastocytosis without the D816V c-kit mutation

Treatment of adult patients with aggressive mastocytosis (ASM) without the D816V c-Kit mutation or with c-Kit mutational status unknown 09.09.2005 19.10.2006

Imatinib mesylate Gleevec

Treatment of myeloproliferative disorders/myelodysplastic syndromes associated with platelet-derived growth factor gene re-arrangements

Treatment of adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with PDGFR (platelet-derived growth factor 05.10.2005 19.10.2006

Imatinib mesylate Gleevec

Treatment of idiopathic hypereosinophilic syndrome including acute and chronic eosinophilic leukemia

Treatment of adult patients with hypereosinophic syndrome (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1-PDGFRα 25.08.2005 19.10.2006

imatinib mesylate Gleevec

Treatment of Philadelphia-positive acute lymphoblastic leukemia

Treatment of adult patients with relapsed or refractory Philadelphia chromosome positive acute 11.10.2005 19.10.2006

imatinib mesylate Gleevec Treatment of dermatofibrosarcoma protuberans

Treatment of adult patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans (DFSP) 19.12.2005 19.10.2006

Coagulation factor VIIa (recombinant) NovoSeven

Prevention of bleeding episodes in patients with acquired inhibitors to Factor VIII or Factor IX

Prevention of bleeding in surgical interventions or invasive procedures in patients with acquired hemophilia 21.07.2004 13.10.2006

Coagulation Factor VIIa (Recombinant) NovoSeven

Treatment of bleeding episodes in patients with acquired inhibitors to Factor VIII or Factor IX

Treatment of bleeding episodes in surgical interventions or invasive procedures in patients with acquired hemophilia 16.07.2004 13.10.2006

vorinostat Zolinza Treatment of T-cell non-Hodgkin's lymphoma

Treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistant or 16.03.2004 06.10.2006

biocarbonate infusate Normocarb HF

Use in the management of patients undergoing continuous renal replacement therapy with hemofiltration

Use as a replacement solution in Continuous Renal Replacement Therapy (CRRT) to replace water and to correct electrolytes and acid-base 09.08.2005 26.07.2006

idursulfase Elaprase

Long term enzyme replacement therapy for patients with mucopolysaccharidosis II (Hunter Syndrome)

Indicated for patients with Hunter syndrome (mucopolysaccharidosis II, MPS II). Idursulfase has been shown to improve walking capacity in these 28.11.2001 24.07.2006

lenalidomide Revlimid Treatment for multiple myeloma

For use in combination with dexamethasone for the treatment of multiple myeloma patients who have received at least one prior therapy. 20.09.2001 29.06.2006

Dasatinib Sprycel

Treatment of Philadelphia-positive acute lymphoblastic leukemia

Treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior 18.11.2005 28.06.2006

Dasatinib Sprycel Treatment of chronic myelogenous leukemia

Treatment of adults with chronic myeloid leukemia with resistance or intolerance to prior therapy including imatinib 28.11.2005 28.06.2006

Thalidomide Thalomid Treatment of multiple myelomaTreatment of patients with newly diagnosed multiple myeloma 14.10.1998 25.05.2006

Infliximab REMICADE

Treatment of pediatric (0 to 16 years of age) Crohn's Disease

For reducing signs and symptoms and inducing and maintaining clinical remission in pediatric patients with moderately to severely active Crohn's 12.11.2003 19.05.2006

Decitabine Dacogen Treatment of myelodysplastic syndromes.

for treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary 08.03.1999 02.05.2006

Recombinant human acid alpha-glucosidase Myozyme Treatment of glycogen storage disease type II.

For use in patients with Pompe disease (GAA deficiency). Alglucosidase alfa has been shown to improve ventilator-free survival in 19.08.1997 28.04.2006

Ibuprofen lysine NeoProfen Treatment of patent ductus arteriosus.

For closure of a clinically significant patent ductus arteriosus in premature infants weighing between 500 and 1500 g, who are no more than 32 29.10.1996 13.04.2006

Tacrolimus Prograf

Prophylaxis of organ rejection in patients receiving heart transplants.

Prophylaxis of organ rejection in patients receiving allogenic heart transplants. 06.06.2005 29.03.2006

Cetuximab Erbitux

Treatment of squamous cell cancer of the head and neck in patients who express epidermal growth factor receptor.

For use in combination with radiation therapy, for the treatment of locally or regionally advanced squamous cell carcinoma of the head and neck 03.07.2000 01.03.2006

lenalidomide Revlimid Treatment of myelodysplastic syndromes

Treatment of patients with transfusion dependant anemia due to low or intermediate-1 risk myelodysplastic syndromes associated with a deletion 29.01.2004 27.12.2005

Sorafenib Nexavar Treatment of renal cell carcinoma.Treatment of patients with advanced renal cell carcinoma 08.10.2004 20.12.2005

mecasermin rinfabate iPLEX

Treatment of growth hormone insensitivity syndrome (GHIS)

Treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone (GH) gene deletion who 17.05.2002 12.12.2005

oxybate Xyrem Treatment of narcolepsyTreatment of excessive daytime sleepiness in patients with narcolepsy 07.11.1994 18.11.2005

Deferasirox Exjade

Treatment of chronic iron overload in patients with transfusion-dependent anemias

Treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age or older 21.11.2002 02.11.2005

nelarabine Arranon

Treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma

Treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose 10.08.2004 28.10.2005

Mecasermin Increlex Treatment of growth hormone insensitivity syndrome.

Long-term treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with 12.12.1995 30.08.2005

Coagulation factor VIIa (recombinant) NovoSeven

Prevention of bleeding episodes in patients with hemophilia A or B, with or without inhibitors

Prevention of bleeding in surgical interventions or invasive procedures in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX 18.06.2004 12.08.2005

quinine Sulfate Treatment of malaria Treatment of uncomplicated Plasmodium falciparum malaria 03.06.2004 12.08.2005

meloxicam Mobic Treatment of juvenile rheumatoid arthritis

For relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis in patients 2 years of age or older 22.11.2002 11.08.2005

Coagulation factor VIIa (recombinant) NovoSeven

Prevention of bleeding episodes in patients with congenital Factor VII deficiency

Prevention of bleeding in surgical interventions or invasive procedures in patients with congenital F VII deficiency 10.09.2004 11.07.2005

Coagulation factor VIIa (recombinant) NovoSeven

Treatment of bleeding episodes in patients with congenital factor VII deficiency

Treatment of bleeding episodes in patients with Factor VII Deficiency 10.09.2004 11.07.2005

N-acetylgalactosamine-4-sulfatase, recombinant human Naglazyme

Treatment of mucopolysaccharidosis Type VI (Maroteaux-Lamy syndrome).

For patients with mucopolysaccharidosis VI. Galsulfase has been shown to improve walking and stair-climbing 17.02.1999 31.05.2005

Fluocinolone Retisert

Treatment uveitis involving the posterior segment of the eye.

Treatment of chronic non-infectious uveitis affecting the posterior segment of the eye 31.07.2000 08.04.2005

Bortezomib Velcade Treatment of multiple myeloma

Treatment of multiple myeloma patients who have received at least one prior therapy 15.01.2003 25.03.2005

temozolomide Temodar Treatment of malignant glioma

Treatment of adult patients with newly diagnosed glioblastoma multiforme concomitatly with radiotherapy and 05.10.1998 15.03.2005

Vaccinia Immune Globulin (Human) Intravenous

Treatment of severe complications from the smallpox vaccine

Treatment and modification of aberrant infections induced by vaccinia virus that include its accidental implantation in eyes 18.06.2004 18.02.2005

benzoate/phenylacetate Ammonul

Treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle.

Adjunctive therapy in the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the 22.11.1993 17.02.2005

Iloprost inhalation solution Ventavis Treatment of pulmonary arterial hypertension

Treatment of pulmonary arterial hypertension (WHO Group I) in patients with NYHA Class III or IV symptoms 17.08.2004 29.12.2004

clofarabine Clolar Treatment of acute lymphoblastic leukemia

Treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at 07.02.2002 28.12.2004

Recombinant human luteinizing hormone Luveris

stimulating hormone for the treatment of women with chronic anovulation due to hypogonadotropic

concomitantly administered with Gonal-f (follitropin alfa for injection), is 07.10.1994 08.10.2004

multi-vitiam infusion without vitamin K M.V.I.-12

complicationsin people receiving home parenteral nutrition and warfarin-type anticoagulant therapy

Prevention of vitamin deficiency and thrombormbolic complications in people receiving home parenteral nutrition who also receive warfarin- 08.03.2004 09.09.2004

Diethylenetriaminepentaacetic acid (DTPA)

Treatment of patients with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination.

Treatment of internal contamination with plutonium, americium or curium 28.04.2004 11.08.2004

Glutamine NutreStore

For use with human growth hormone in the treatment of short bowel syndrome (nutrient malabsorption from the gastrointestinal tract resulting from an inadequate absorptive surface).

Treatment of short bowel syndrome in patients receiving specialized nutritional support when used in conjunction with a rercombinant 06.03.1995 10.06.2004

azacitidine Vidaza Treatament of myelodysplastic syndromes

Treatment of patients with the following myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed 03.12.2001 19.05.2004

tinidazole Tindamax Treatment of giardiasis

Treatment of giardiasis caused by G. duodenalis (also termed G. lamblia) in both adults and pediatric patients older than three years of age 18.04.2002 17.05.2004

Tinidazole Tindamax Treatment of amebiasis

Treatment of intestinal amebiasis and amebic liver abcess caused by E. histolytica in both adults and pediatric patients older than three years of age. 20.08.2003 17.05.2004

Apomorphine HCl Apokyn

Treatment of the on-off fluctuations associated with late-stage Parkinson's disease.

For the acute, intermittent treatment of hypomobility, "off" episodes ("end-of-dose-wearing-off" and unpredictable :on/off" episodes) associated with 22.04.1993 20.04.2004

cinacalcet Sensipar

Treatment of hypercalcemia in patients with parathyroid carcinoma

Treatment of hypercalcemia in patients with parathyroid carcinoma 12.05.2003 08.03.2004

pemetrexed disodium Alimta Treatment of malignant pleural mesothelioma

Treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative 28.08.2001 04.02.2004

acetylcysteine Acetadote

For the intravenous treatment of moderate to severe acetaminophen overdose

For the use of Acetadote(registered TM) Injection, administered intravenously within 8 to 10 hours after ingestion of a potentially heptotoxic quantity of acetaminophen, 19.10.2001 23.01.2004

Somatropin (r-DNA) Zorbtive

For use alone or in combination with glutamine in the treatment of short bowel syndrome.

Treatment of short bowel syndrome in patients receiving specialized nutritional support 06.03.1995 01.12.2003

Botulism immune globulin BabyBIG Treatment of infant botulism.

Indicated for treatment of infant botulism caused by type A or type B Clostridium botulinum.

31.01.1989 23.10.2003

iron(III)-hexacyanoferrate(II) Radiogardase

Treatment of patients with known or suspected internal contamination with radioactive or non-radioactive cesium or thallium

Treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase 01.05.2003 02.10.2003

porfimer Photofrin

For the ablation of High-Grade Dysplasia in Barrett's Esophagus in patients who are not considered to be candidates for esophagectomy

For the ablation of high-grade dysplasia in Barrett's esophagus patients who do not undergo esophagectomy 19.10.2001 01.08.2003

miglustat Zavesca Treatment of Gaucher disease.

Treatment of mild to moderate Type I Gaucher disease in adults for whom enzyme replacement therapy is not a therapeutic option (e.g., due to 29.05.1998 31.07.2003

ribavirin REBETOL Treatment of chronic hepatitis C in pediatric patients

Treatment of chronic hepatitis C among previously untreated pediatric patients at least three years of age or 04.04.2003 29.07.2003

Tositumomab and iodine I 131 tositumomab Bexxar Treatment of non-Hodgkin's B-cell lymphoma.

Treatment of patients with CD20 positive, follicular, non-Hodgkin's lymphoma, with and without transformation, whose disease is 16.05.1994 27.06.2003

bortezomib Velcade Treatment of multiple myeloma

Treatment of multiple myeloma patients who have received at least two prior therapies and have demonstrated disease progression on 15.01.2003 13.05.2003

laronidase Aldurazyme Treatment of patients with mucopolysaccharidosis-I.

Treatment for patients with Hurler and Hurler-Scheie forms of Mucopolysaccharidosis I (MPS I) and for patients with the Scheie form who 24.09.1997 30.04.2003

Ceramide trihexosidase/alpha-galactosidase A Fabrazyme Treatment of Fabry's disease.

For use in patients with Fabry disease to reduce globotriaosylceramide (GL-3) deposition in capillary endothelium of the kidney and certain other cell 19.01.1988 24.04.2003

Pegvisomant Somavert Treatment of acromegaly.

Treatment of acromegaly in patients who have had an inadequate response to surgery and/or radiation therapy and/or other medical 24.06.1997 25.03.2003

polifeprosan 20 with carmustine Gliadel Treatment of malignant glioma

Expanding the indication to include patients with malignant glioma undergoing primary surgical resection. 13.12.1989 25.02.2003

Icodextrin 7.5% with Electrolytes Peritoneal Dialysis Solution Extraneal (with 7.5% Ic

Treatment of those patients having end stage renal disease and requiring peritoneal dialysis treatment.

For use as a single daily exchange for the long (8-16 hour) dwell during continuous ambulatory peritoneal dialysis (CAPD) or automated 18.07.1997 20.12.2002

nitazoxanide Alinia Treatment of intestinal giardiasis

Treatment of diarrhea caused by Cryptosporidium parvum and Giardia lamblia 14.02.2002 22.11.2002

Nitazoxanide Alinia Treatment of cryptosporidiosis.

Treatment of diarrhea caused by Cryptosporidium parvum and Giardia lamblia 12.12.1996 22.11.2002

Synthetic porcine secretin For use in the evaluation of exocrine pancreas function.

For use in secretin stimulation testing for: Stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater 18.06.1999 01.11.2002

Buprenorphine hydrochloride Subutex Treatment of opiate addiction in opiate users.Treatment of opioid dependence in patients 16 years of age or older 15.06.1994 08.10.2002

Buprenorphine in combination with naloxone Suboxone Treatment of opiate addiction in opiate users.

Treatment of opioid dependence in patients 16 years of age or older 27.10.1994 08.10.2002

oxybate Xyrem Treatment of narcolepsy.Treatment of cataplexy associated with narcolepsy. 07.11.1994 17.07.2002

rasburicase Elitek

Treatment of malignancy-associated or chemotherapy-induced hyperuricemia.

Initial management of plasma uric acid levels in pediatric patients with leukemia,lymphoma, and solid tumor malignancies who are receiving anti- 11.10.2000 12.07.2002

treprostinil Remodulin Treatment of pulmonary arterial hypertension.Treatment of pulmonary arterial hypertension. 04.06.1997 21.05.2002

Synthetic porcine secretin

For use in conjunction with diagnostic procedures for pancreatic disorders to increase pancreatic fluid secretion.

Use in secretin stimulation testing for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine 07.03.2000 04.04.2002

Synthetic porcine secretinFor use in the diagnosis of gastrinoma associated with Zollinger-Ellison syndrome.

Use in secretin stimulation testing for stimulation of gastrin secretion to aid in the diagnosis of gastrinoma 18.06.1999 04.04.2002

ibritumomab tiuxetan Zevalin Treatment of B-cell non-Hodgkin's lymphoma.

Treatment of patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin?s lymphoma, including patients with 06.09.1994 19.02.2002

imatinib mesylate Gleevec Treatment of gastrointestinal stromal tumors

Treatment of patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST) 01.11.2001 01.02.2002

Nitisinone Orfadin Treatment of tyrosinemia type 1.

Adjunctive therapy to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 16.05.1995 18.01.2002

Bosentan Tracleer Treatment of pulmonary arterial hypertension.Treatment of pulmonary arterial hypertension. 06.10.2000 20.11.2001

Topiramate Topamax Treatment of Lennox-Gastaut syndrome.years and older with siezures associated with Lennox-Gastaut 25.11.1992 28.08.2001

Zoledronate Zometa, Zabel Treatment of tumor induced hypercalcemia. Treatment of hypercalcemia of malignancy. 18.08.2000 20.08.2001

somatropin [rDNA] Genotropin

Treatment of growth failure in children who were born small for gestational age.

For long-term treatment of growth failure in children born small for gestational age who fail to manifest catch-up growth by two years of age. 27.12.2000 25.07.2001

Imatinib Gleevec Treatment of chronic myelogenous leukemia

Treatment of patients with chronic myeloidleukemia (CML) in blast crisis, accelerated phase, or in chronic 31.01.2001 10.05.2001

alemtuzumab Campath Treatment of chronic lymphocytic leukemia.

The treatment of patients with B-cell chronic lymphocytic leukemia who have been treated with alkylating agents and who have failed 20.10.1997 07.05.2001

Botulinum toxin type A Botox Treatment of cervical dystonia.

Treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia. 20.08.1986 21.12.2000

Botulinum toxin type B Myobloc Treatment of cervical dystonia.

Treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia. 16.01.1992 08.12.2000

Fomepizole Antizole Treatment of methanol or ethylene glycol poisoning.

Use for suspected or confirmed methanol poisoning, either alone or in combination with hemodialysis 22.12.1988 08.12.2000

Mitoxantrone Novantrone Treatment of secondary-progressive multiple sclerosis.

Reducing neurologic disability and/or the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or 13.08.1999 13.10.2000

Mitoxantrone Novantrone Treatment of progressive-relapsing multiple sclerosis.

Reducing neurologic disability and/or the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or 13.08.1999 13.10.2000

Antivenin, crotalidae polyvalent immune Fab (ovine) CroFab

Treatment of envenomations inflicted by North American crotalid snakes.

Carol Clark-Evans direct line (615) 963-4510 12.01.1994 02.10.2000

Arsenic trioxide Trisenox Treatment of acute promyelocytic leukemia.

For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, 03.03.1998 25.09.2000

Somatropin [rDNA] Genotropin

Treatment of short stature in patients with Prader-Willi syndrome.

Long-term treatment of pediatric patients who have growth failure due to Prader-Willi syndrome (PWS). 06.07.1999 20.06.2000

Follitropin alfa, recombinant Gonal-F

For the initiation and re-initiation of spermatogenesis in adult males with reproductive failure due to hypothalamic or pituitary dysfunction, hypogonadotropic hypogonadism. AMENDED indication 6/27/00: For the

For the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due 21.12.1998 24.05.2000

Gemtuzumab zogamicin Mylotarg Treatment of CD33-positive acute myeloid leukemia.

Treatment of patients with CD33 positive acute myeloid leukemia in first relapse who are 60 years of age or older and who are not considered 24.11.1999 17.05.2000

Epoprostenol Flolan

Treatment of secondary pulmonary hypertension due to intrinsic precapillary pulmonary vascular disease.

For the long-term intravenous treatment of pulmonary hypertension associated with the scleroderma spectrum of disease in New York 22.03.1999 14.04.2000

Interferon gamma-1b Actimmune

Delaying time to disease progression in patients with severe, malignant osteopetrosis.

Delaying time to disease progression in patients with severe, malignant osteopetrosis. 30.09.1996 10.02.2000

Bexarotene Targretin Treatment of cutaneous T-cell lymphoma.

Treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior 18.06.1999 29.12.1999

Nitric oxide INOmax

Treatment of persistent pulmonary hypertension in the newborn.

In conjunction with ventilatory support and other appropriate agents, in the treatment of term and near-term (>34 weeks) neonates with hypoxic 22.06.1993 23.12.1999

Levocarnitine Carnitor

Treatment of manifestations of carnitine deficiency in patients with end stage renal disease who require dialysis.

Prevention and treatment of carnitine deficiency in patients with end stage renal disease who are undergoing dialysis. 06.09.1988 15.12.1999

Exemestane Aromasin

Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy. 19.09.1991 21.10.1999

Caffeine Cafcit Treatment of apnea of prematurity.

Short term treatment of apnea of prematurity in infants between 28 and less than 33 weeks gestational age. 20.09.1988 21.09.1999

Epirubicin Ellence Treatment of breast cancer.

Component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer. 14.09.1999 15.09.1999

Temozolomide Temodar Treatment of recurrent malignant glioma.

Treatment of adult patients with refractory anaplastic astrocytoma, i.e., patients at first relapse who have experienced disease progression on a 05.10.1998 11.08.1999

Doxorubicin liposome Doxil Treatment of ovarian cancer.

Treatment of metastatic carcinoma of the ovary in patients with disease that is refractory to both paclitaxel- and platinium-based chemotherapy 04.11.1998 28.06.1999

Amifostine Ethyol

Reduction of the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Reduction of the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck 12.05.1998 24.06.1999

etanercept Enbrel

Reduction in signs and symptoms of moderately to severely active polyarticular-course juvenile rheumatoid arthritis in patients who have had an inadequate response to one or more disease-modifying anti-

Reduction in signs and symptoms of moderately to severely active polyarticular-course juvenile rheumatoid arthritis in patients who 27.10.1998 27.05.1999

Antihemophilic factor/von Willebrand factor complex (human), dried, pasteurized Humate-P

Treatment of patients with von Willebrand's disease

(1) In adult patients for treatment and prevention of bleeding in hemophilia A (classic hemophilia) and (2) in adult and pediatric patients for treatment of 16.10.1992 01.04.1999

Cytarabine liposomal DepoCyt Treatment of neoplastic meningitis.Intrathecal treatment of lymphomatous meningitis. 02.06.1993 01.04.1999

Coagulation factor VIIa (recombinant) NovoSeven

Treatment of bleeding episodes in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX.

Treatment of bleeding episodes in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX. 06.06.1988 25.03.1999

Lidocaine patch 5% Lidoderm Patch

For relief of allodynia (painful hypersensitivity), and chronic pain in postherpetic neuralgia. 24.10.1995 19.03.1999

denileukin diftitox Ontak Treatment of patients with cutaneous T-cell lymphoma

Treatment of patients with persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the 21.08.1996 05.02.1999

Busulfan Busulfex

As preparative therapy in the treatment of malignancies with bone marrow transplantation.

For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell 28.07.1994 04.02.1999

Alitretinoin Panretin Treatment of AIDS-related Kaposi's sarcoma.

Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. 24.03.1998 02.02.1999

Atovaquone Mepron

Prevention of Pneumocystis carinii pneumonia (PCP) in high-risk, HIV-infected patients defined by a history of one or more episodes of PCP and/or a peripheral CD4+ (T4 helper/inducer) lymphocyte count less than or equal

Prevention of PCP in patients who are intolerant to trimethoprim-sulfamethoxazole. 14.08.1991 05.01.1999

Modafinil Provigil

Treatment of excessive daytime sleepiness in narcolepsy.

Improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy. 15.03.1993 24.12.1998

Cytomegalovirus immune globulin (human) CytoGam

Prevention or attenuation of primary cytomegalovirus disease in immunosuppressed recipients of organ transplants.

#1) Attenuation of primary CMV disease associated with kidney transplant recipients who are seronegative for CMV and who receive a kidney from a CMV seropositve donor; #2) Prophylaxis of CMV disease associated transplantation of kidney (all other), lung, 03.08.1987 04.12.1998

Thyrotropin alpha Thyrogen As an adjunct in the diagnosis of thyroid cancer.

As an adjunctive diagnostic tool for serum thyroglobulin (Tg) testing with or without radioiodine imaging in the follow-up of patients with thyroid 24.02.1992 30.11.1998

Octreotide Sandostatin LAR

Treatment of severe diarrhea and flushing associated with malignant carcinoid tumors.

Supression of severe diarrhea and flushing associated with malignant carcinoid syndrome. 24.08.1998 25.11.1998

Octreotide Sandostatin LAR Treatment of acromegaly.Reduction of growth hormone and IGF-1 (somatomedin C) in acromegaly. 24.08.1998 25.11.1998

Octreotide Sandostatin LAR

Treatment of diarrhea associated with vasoactive intestinal peptide tumors (VIPoma).

Treatment of profuse watery diarrhea associated with VIPoma. 24.08.1998 25.11.1998

Valrubicin Valstar Treatment of carcinoma in situ of the urinary bladder.

For intravesical therapy of BCG-refractory carcinoma in situ of the urinary bladder in patients for whom 23.05.1994 25.09.1998

Infliximab Remicade

Treatment of moderately to severely active Crohn's disease for the reduction of the signs and symptoms, in patients who have an inadequate response to conventional therapy; and treatment of patients with

Treatment of moderately to severely active Crohn's disease for the reduction of the signs and symptoms, in patients who have an inadequate 14.11.1995 24.08.1998

Lamotrigine Lamictal Treatment of Lennox-Gastaut syndrome.

Adjunctive treatment of Lennox-Gastaut syndrome in pediatric and adult patients. 23.08.1995 24.08.1998

Thalidomide Thalomid Treatment of erythema nodosum leprosum.

Acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and as maintenance therapy for 26.07.1995 16.07.1998

Rifapentine Priftin Treatment of pulmonary tuberculosis. 09.06.1995 22.06.1998

Mafenide acetate solution Sulfamylon solution

For use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds. 18.07.1990 05.06.1998

Basiliximab Simulect

Prophylaxis of solid organ rejection.

Prophylaxis of acute organ rejection in patients receiving renal transplantation when used as part of an immunosuppressive regimen that 12.12.1997 12.05.1998

Sacrosidase Sucraid Treatment of congenital sucrase-isomaltase deficiency.

Oral replacement therapy of the genetically determined sucrase deficiency, which is part of congenital sucrease-isomaltase deficiency. 10.12.1993 09.04.1998

Filgrastim Neupogen

Reduction in the duration of neutropenia, fever, antibiotic use, and hospitalization, following induction and consolidation treatment for acute myeloid leukemia.

Reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of adults with 07.11.1996 02.04.1998

Lepirudin Refluden

Treatment of heparin-associated thrombocytopenia type II.

For anticoagulation in patients with heparin-induced thrombocytopenia and associated thromboembolic disease in order to prevent further 13.02.1997 06.03.1998

Hydroxyurea Droxia

Treatment of patients with sickle cell anemia as shown by the presence of hemoglobin S.

To reduce the frequency of painful crises and to reduce the need for blood transfusions in adult patients with sickle cell anemia with recurrent 01.10.1990 25.02.1998

Pilocarpine HCl Salagen

Treatment of xerostomia and keratoconjunctivitis sicca in Sjogren's syndrome patients.

Treatment of dry mouth in patients with Sjogren's syndrome. 28.02.1992 11.02.1998

Aldesleukin Proleukin Treatment of metastatic melanoma.Treatment of adults with metastatic melanoma. 10.09.1996 09.01.1998

Sterile talc powder Sclerosol Intrapleural ATreatment of malignant pleural effusion.

Prevention of recurrence of malignant pleural effusions in symptomatic patients. 18.09.1995 24.12.1997

Tobramycin for inhalation TOBI

Treatment of bronchopulmonary infections of Pseudomonas aeruginosa in cystic fibrosis patients.

Management of cystic fibrosis patients with P.aeruginosa. 13.10.1994 22.12.1997

Somatropin for injection Nutropin

As replacement therapy for growth hormone deficiency in adults after epiphyseal closure. 18.11.1996 15.12.1997

Daclizumab Zenapax Prevention of acute renal allograft rejection.

Prophylaxis of acute organ rejection in patients receiving renal transplants, to be used as a part of an immunosuppressive regimen that 05.03.1993 10.12.1997

Ursodiol URSO Treatment of patients with primary biliary cirrhosis. 20.06.1991 10.12.1997

Fomepizole Antizole Treatment of methanol or ethylene glycol poisoning.

As an antidote to ethylene glycol (antifreeze) poisoning, or for use in suspected ethylene glycol ingestion. 22.12.1988 04.12.1997

rituximab Rituxan Treatment of non-Hodgkin's B-cell lymphoma. 13.06.1994 26.11.1997

Oprelvekin Neumega

Prevention of severe chemotherapy-induced thrombocytopenia. 17.12.1996 25.11.1997

Somatropin Genotropin Treatment of adults with growth hormone deficiency. 06.09.1994 31.10.1997

Sermorelin acetate Geref

Treatment of idiopathic or organic growth hormone deficiency in children with growth failure. 14.09.1988 26.09.1997

Liposomal amphotericin B AmBisome Treatment of visceral leishmaniasis. Treatment of visceral leishmaniasis. 06.12.1996 11.08.1997

Liposomal amphotericin B AmBisome Treatment of cryptococcal meningitis.Treatment of disseminated cryptococcosis including meningitis. 10.12.1996 11.08.1997

Paclitaxel Taxol Treatment of AIDS-related Kaposi's sarcoma.For the second line treatment of AIDS-related Kaposi's sarcoma. 25.03.1997 04.08.1997

Diazepam viscous solution for rectal administration

For the management of selected, refractory, patients with epilepsy, on stable regimens of antiepileptic drugs (AEDs), who require intermittent use of diazepam to control bouts of increased seizure activity. 25.02.1992 29.07.1997

Toremifene Fareston

Hormonal therapy of metastatic carcinoma of the breast.

Treatment of metastatic breast cancer in postmenopausal women with estrogen positive or receptor unknown 19.09.1991 29.05.1997

Anagrelide Agrylin Treatment of essential thrombocythemia.

Treatment of patients with essential thrombocythemia to reduce the elevated platelet count and the risk of thrombosis and to ameliorate 27.01.1988 14.03.1997

Coagulation Factor IX (recombinant) BeneFix Treatment of hemophilia B.

For the control and prevention of hemorrhagic episodes in patients with hemophilia B (congenital factor IX deficiency and Christmas disease), 03.10.1994 11.02.1997

Zinc acetate Galzin Treatment of Wilson's disease.

For maintenance treatment of patients with Wilson's disease who have been initially treated with a chelating agent. 06.11.1985 28.01.1997

Somatropin Humatrope

Treatment of short stature associated with Turner syndrome.

Treatment of short stature associated with Turner syndrome in patients whose epiphyses are not closed. 08.05.1990 30.12.1996

Somatropin for injection Nutropin

Treatment of short stature associated with Turner's syndrome.

Treatment of growth failure associated with Turner syndrome. 23.03.1989 30.12.1996

Glatiramer acetate Copaxone Treatment of multiple sclerosis.relapses in patients with relapsing-remitting multiple sclerosis. 09.11.1987 20.12.1996

Mitoxantrone Novantrone Treatment of hormone refractory prostate cancer.

In combination with corticosteroids as initial chemotherapy for the treatment of patients with pain related to 21.08.1996 13.11.1996

Betaine Cystadane Treatment of homocystinuria.

Treatment of homocystinuria to decrease elevated homocysteine blood levels. 16.05.1994 25.10.1996

Amphotericin B lipid complex Abelcet Treatment of invasive fungal infections.

Treatment of invasive fungal infections in patients who are refractory to or intolerant of 05.12.1991 18.10.1996

Clonidine Duraclon

For continous epidural administration as adjunctive therapy with intraspinal opiates for the treatment of pain in cancer patients tolerant to, or unresponsive to,

In combination with opiates for the treatment of severe pain in cancer patients that is not adequately relieved 24.01.1989 02.10.1996

Buffered intrathecal electrolyte/dextrose injection Elliotts B Solution

For use as a diluent in the intrathecal administration of methotrexate and cytarabine for the prevention or treatment meningeal leukemia and lymphocytic lymphoma.

For the intrathecal administration of methotrexate and cytarabine for the prevention or treatment of meningeal leukemia and lymphocytic lymphoma. 24.08.1994 27.09.1996

Pentosan polysulfate sodium Elmiron Treatment of interstitial cystitis.Relief of bladder pain or discomfort associated with interstitial cystitis. 07.08.1985 26.09.1996

polifeprosan 20 with carmustine Gliadel Treatment of malignant glioma.

As an adjunct to surgery to prolong survival in patients with recurrent glioblastoma multiforme for whom surgical resection is indicated 13.12.1989 23.09.1996

Midodrine HCl Amatine

Treatment of patients with symptomatic orthostatic hypotension.

Treatment of symptomatic orthostatic hypotension. 05.12.1996 06.09.1996

Somatropin for injection Serostim Treatment of AIDS-associated catabolism/weight loss.Treatment of AIDS wasting or cachexia. 15.11.1991 23.08.1996

Fosphenytoin Cerebyx

For the acute treatment of patients with status epilepticus of the grand mal type.

For the control of generalized convulsive status epilepticus. 04.06.1991 05.08.1996

Albendazole Albenza

Treatment of neurocysticercosis due to Taenia solium as: 1) chemotherapy of parenchymal, subarachnoidal and racemose (cysts in spinal fluid) neurocysticercosis in symptomatic cases and 2) prophylaxis of epilepsy

Treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium. 18.01.1996 11.06.1996

Albendazole Albenza

Treatment of hydatid disease (cystic echinococcosis due to E. granulosus larvae or alveolar echinococcosis due to E. multilocularis larvae).

Treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus. 17.01.1996 11.06.1996

Corticorelin ovine triflutate Acthrel

For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.

To differentiate between pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome. 24.11.1989 23.05.1996

Ofloxacin Ocuflox Ophthalmic SoTreatment of bacterial corneal ulcers. Treatment of bacterial corneal ulcers. 18.04.1991 22.05.1996

Allopurinol sodium Aloprim for Injection

Management of patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels and who cannot tolerate oral therapy.

Management of patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes 16.10.1992 17.05.1996

Interferon beta-1a Avonex Treatment of multiple sclerosis.

Treatment of relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical 16.12.1991 17.05.1996

sodium phenylbutyrate Buphenyl

Treatment of urea cycle disorders: carbamylphosphate synthetase deficiency, ornithine transcarbamylase deficiency, and arginiosuccinic acid synthetase deficiency.

Adjunctive therapy in the chronic managment of patients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase, 22.11.1993 30.04.1996

Daunorubicin citrate liposome injection DaunoXome

Treatment of patients with advanced HIV-associated Kaposi's sarcoma.

First line cytotoxic therapy for advanced, HIV related Kaposi's sarcoma. 14.05.1993 08.04.1996

Ganciclovir intravitreal implant Vitrasert Implant Treatment of cytomegalovirus retinitis.

Treatment of CMV retinitis in patients with acquired immunodeficiency syndrome. 07.06.1995 04.03.1996

Bleomycin sulfate Blenoxane Treatment of malignant pleural effusion.Treatment of malignant pleural effusion. 17.09.1993 20.02.1996

Respiratory syncytial virus immune globulin (Human) Respigam

Prophylaxis of respiratory syncytial virus lower respiratory tract infections in infants and young children at high risk of RSV disease.

For the prevention of serious lower respiratory tract infections caused by RSV in children less than 24 months of age with bronchopulmonary 27.09.1990 18.01.1996

Filgrastim Neupogen

For use in the mobilization of peripheral blood progenitor cells for collection in patients who will receive myeloablative or myelosuppressive chemotherapy.

For use in the mobilization of hematopoietic progenitor cells into the peripheral blood collection by leukapheresis. 17.07.1995 28.12.1995

Porfimer sodium Photofrin

For the photodynamic therapy of patients with primary or recurrent obstructing (either partially or completely) esophageal carcinoma.

Photodynamic therapy with PHOTOFRIN for the palliation of patients with completely obstructing esophageal cancer, or of patients with 06.06.1989 27.12.1995

Riluzole Rilutek Treatment of amyotrophic lateral sclerosis.

Treatment of patients with amyotrophic lateral sclerosis. Riluzole extends survival and/or time to tracheostomy. 16.03.1993 12.12.1995

Amifostine Ethyol

For use as a chemoprotective agent for cisplatin in the treatment of advanced ovarian carcinoma.

To reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. 30.05.1990 08.12.1995

Tretinoin Vesanoid Treatment of acute promyelocytic leukemia.

Induction of remission in patients with acute promyelocytic leukemia who are refractory to or unable to tolerate anthracycline based cytotoxic 24.10.1990 22.11.1995

Interferon alfa-2a Roferon A Treatment of chronic myelogenous leukemia.Treatment of chronic myelogenous leukemia. 06.06.1989 19.10.1995

Epoprostenol Flolan Treatment of primary pulmonary hypertension.

Long-term intravenous treatment of primary pulmonary hypertension in NYHA Class III and Class IV patients. 25.09.1985 20.09.1995

Sargramostim Leukine

To reduce neutropenia and leukopenia and decrease the incidence of death due to infection in patients with acute myelogenous leukemia.

Following induction chemotherapy in older adult patients with acute myelogenous leukemia to shorten time to neutrophil recovery and to 06.03.1995 15.09.1995

Amiodarone HCl Cordarone

For the acute treatment and prophylaxis of life-threatening ventricular tachycardia or ventricular fibrillation.

For initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular 16.03.1994 03.08.1995

Dexrazoxane Zinecard

For the prevention of cardiomyopathy associated with doxorubicin administration.

Cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative dose of 17.12.1991 26.05.1995

Rho (D) immune globulin intravenous (human) WinRho SD Treatment of immune thrombocytopenic purpura.

Treatment of adults and children with chronic and acute immune thrombocytopenic purpura. 09.11.1993 24.03.1995

Filgrastim Neupogen

Treatment of patients with severe chronic neutropenia (absolute neutrophil count less than 500/mm3).

Treatment of patients with severe chronic neutropenia. 07.11.1990 19.12.1994

Cysteamine Cystagon Treatment of nephropathic cystinosis.Treatment of nephropathic cystinosis in adults and children. 25.01.1991 15.08.1994

Sulfadiazine

For use in combination with pyrimethamine for the treatment of Toxoplasma gondiiencephalitis in patients with and without AIDS.

Toxoplasmosis, as adjunctive with pyrimethamine 14.03.1994 29.07.1994

Aminosalicylic acid Paser Granules Treatment of tuberculosis infections Treatment of tuberculosis 19.02.1992 30.06.1994

Filgrastim Neupogen

Treatment of neutropenia associated with bone marrow transplants.

Reduce the duration of neutropenia and neutropenia sequelae in patients with non-myeloid malignancies undergoing ablative chemotherapy 01.10.1990 15.06.1994

Rifampin, isoniazid, pyrazinamide Rifater For the short-course treatment of tuberculosis.Short-course treatment of tuberculosis. 12.09.1985 31.05.1994

Imiglucerase Cerezyme

Replacement therapy in patients with types I, II, and III Gaucher's disease.

Enzyme replacement therapy in patients with type I Gaucher's disease. 05.11.1991 23.05.1994

Pilocarpine Salagen

Treatment of xerostomia induced by radiation therapy for head and neck cancer.

Treatment of symptoms of xerostomia from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck. 24.09.1990 22.03.1994

Desmopressin acetateTreatment of mild hemophilia A and von Willebrand's disease.

Treatment of patients with hemophilia A or von Willebrand's disease (type I) whose factor VIII coagulant activity level is greater than 5%. 22.01.1991 07.03.1994

Pegaspargase Oncaspar Treatment of acute lymphocytic leukemia.treatment of patients with acute lymphoblastic leukemia who are 20.10.1989 01.02.1994

Dornase alfa Pulmozyme

To reduce mucous viscosity and enable the clearance of airway secretions in patients with cystic fibrosis.

In conjunction with standard therapies in the management of cystic fibrosis patients to reduce the frequency of respiratory infections requiring 16.01.1991 30.12.1993

Aprotinin Trasylol

For prophylactic use to reduce perioperative blood loss and the homologous blood transfusion requirement in patients undergoing cardiopulmonary bypass surgery in the course of repeat coronary artery bypass graft 17.11.1993 29.12.1993

Immune globulin intravenous, human Gamimune N

Infection prophylaxis in pediatric patients affected with the human immunodeficiency virus.

For prophylaxis of children with clinical or immunologic evidence of human immunodeficiency virus to decrease the frequency of serious and minor 18.02.1993 27.12.1993

Trimetrexate glucuronate Neutrexin

Treatment of Pneumocystis carinii pneumonia in AIDS patients.

Concurrent leucovorin administration as an alternative therapy for the treatment of moderate to severe PCP in immunocompromised patients who 15.05.1986 17.12.1993

Somatropin for injection Nutropin

Treatment of growth retardation associated with chronic renal failure.

Treatment of children with growth failure associated with chronic renal insufficency. 04.08.1989 17.11.1993

Lodoxamide tromethamine Alomide Ophthalmic SoTreatment of vernal keratoconjunctivitis.

Treatment of ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis. 16.10.1991 23.09.1993

Megestrol acetate Megace

Treatment of patients with anorexia, cachexia, or significant weight loss (=/>10% of baseline body weight) and confirmed diagnosis of AIDS.

Treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with a diagnosis of 13.04.1988 10.09.1993

Felbamate Felbatol Treatment of Lennox-Gastaut syndrome.

As adjunctive therapy in the treatment of partial and generalized seizures associated with the Lennox-Gastaut 24.01.1989 29.07.1993

Interferon beta-1b Betaseron Treatment of multiple sclerosis.

In ambulatory patients with relapsing-remitting multiple sclerosis to reduce the frequency of clinical exacerbations. 17.11.1988 23.07.1993

Levomethadyl acetate hydrochloride Orlaam

Treatment of heroin addicts suitable for maintenance on opiate agonists.

For the management of opiate dependence. 24.01.1985 09.07.1993

Leuprolide acetate Lupron Injection Treatment of central precocious puberty.Treatment of children with central precocious puberty. 25.07.1988 16.04.1993

Cladribine Leustatin Injection Treatment of hairy cell leukemia. 15.11.1990 26.02.1993

Antihemophilic factor (recombinant) Kogenate

Prophylaxis and treatment of bleeding in individuals with hemophilia A or for prophylaxis when surgery is required in individuals with hemophilia A.

Treatment and prophylaxis of bleeding in patients with hemophilia A (not von Willebrand's disease) 25.09.1989 25.02.1993

Satumomab pendetide Oncoscint CR/OV Detection of ovarian carcinoma.location of extraphepatic malignant disease in patients with known 25.09.1989 29.12.1992

Rifabutin Mycobutin

Prevention of disseminated Mycobacterium avium complex disease in patients with advanced HIV infection.

Prevention of disseminated Mycobacterium avium complex disease in patients with advanced HIV 18.12.1989 23.12.1992

Dronabinol Marinol

For the stimulation of appetite and prevention of weight loss in patients with a confirmed diagnosis of AIDS.

Treatment of anorexia associated with weight loss in patients with AIDS. 15.01.1991 22.12.1992

Levocarnitine Carnitor

Treatment of primary and secondary carnitine deficiency of genetic origin.

Treatment of primary systemic carnitine deficiency. (approved 12/27/85) Treatment of secondary carnitine deficiency. (approved 12/16/92) 26.07.1984 16.12.1992

Atovaquone Mepron

Treatment of AIDS associated Pneumocystis Carinii Pneumonia.

For the acute oral treatment of mild to moderate Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim- 10.09.1990 25.11.1992

Melphalan Alkeran For Injection

Treatment of patients with multiple myeloma for whom oral therapy is inappropriate.

For the palliative treatment of patients with multiple myeloma for whom oral melphalan is not appropriate. 24.02.1992 18.11.1992

Sotalol HCl Betapace

Treatment of life-threatening ventricular tachyarrhythmias. 23.09.1988 30.10.1992

Coagulation factor IX Mononine

Replacement treatment and prophylaxis of the hemorrhagic complications of hemophilia B.

Prevention and control of bleeding in factor IX deficiency, also known as hemophilia B or Christmas disease. 27.06.1989 20.08.1992

Halofantrine Halfan

Treatment of mild to moderate acute malaria caused by susceptible strains of P. falciparum and P. vivax.

Treatment of adults who can tolerate oral medication and who have mild to moderate malaria caused by Plasmodium falciparum or 04.11.1991 24.07.1992

Teniposide Vumon for injection

Treatment of refractory childhood acute lymphocytic leukemia.

Induction therapy in patients with refractory childhood acute lymphoblastic leukemia when used in combination with other approved 01.11.1984 14.07.1992

Baclofen Lioresal Intrathecal

Treatment of intractable spasticity caused by spinal cord injury, multiple sclerosis, and other spinal diseases (including spinal ischemia, spinal tumor, transverse myelitis, cervical spondylosis, and degenerative

Management of severe spasticity of spinal cord origin in patients who are unresponsive to oral baclofen therapy or experience intolerable CNS side 10.11.1987 25.06.1992

Zalcitabine Hivid Treatment of AIDS.

Combination therapy with zidovudine is indicated for the treatment of adult patients with advanced HIV infection (CD4 count < 300) who have 28.06.1988 19.06.1992

Aldesleukin Proleukin Treatment of metastatic renal cell carcinoma.Treatment of adults (>18 years old) with metastatic renal cell carcinoma. 14.09.1988 05.05.1992

Nafarelin acetate Synarel Nasal SolutionTreatment of central precocious puberty.

Treatment of central precocious puberty (gonadotropin-dependent precocious puberty) in children of both sexes. 20.07.1988 26.02.1992

Liothyronine sodium injection Triostat Treatment of myxedema coma/precoma.Treatment of myxedema coma/precoma. 30.07.1990 31.12.1991

Antithrombin III (human) Thrombate III

For replacement therapy in congenital deficiency of AT-III for prevention and treatment of thrombosis and pulmonary emboli. 26.11.1984 30.12.1991

Histrelin acetate Supprelin Injection Treatment of central precocious puberty.Treatment of central precocious puberty. 10.08.1988 24.12.1991

Leucovorin Leucovorin calcium

For use in combination with 5-fluorouracil for the treatment of metastatic colorectal cancer.

For use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with 08.12.1986 12.12.1991

Pentostatin for injection Nipent Treatment of hairy cell leukemia.

Single agent treatment for adult patients with alpha-interferon-refractory hairy cell leukemia. 10.09.1987 11.10.1991

Morphine sulfate concentrate (preservative free) Infumorph

For use in microinfusion devices for intraspinal administration in the treatment of intractable chronic pain.

For intrathecal or epidural infusion in the treatment of tractable chronic pain. It was developed for use in continuous microinfusion devices and may require dilution before use as 12.07.1990 19.07.1991

Beractant Survanta intratracheal sPrevention of neonatal respiratory distress syndrome.

Prevention of RDS (hyaline membrane disease) in premature infants less than 1250 grams birthweight or with evidence of surfactant deficiency. 05.02.1986 01.07.1991

Beractant Survanta intratracheal sTreatment of neonatal respiratory distress syndrome.

Treatment of ("rescue") of premature infants with RDS confirmed by x-ray and requiring mechanical ventilation. 05.02.1986 01.07.1991

Fludarabine phosphate Fludara

Treatment of chronic lymphocytic leukemia (CLL), including refractory CLL. 18.04.1989 18.04.1991

Alglucerase injection Ceredase

For replacement therapy in patients with Gaucher's disease type I.

Long-term enzyme replacement therapy for children, adolescents and adult patients with a confirmed diagnosis of Type I Gaucher disease 11.03.1985 05.04.1991

Sargramostim Leukine

Treatment of neutropenia associated with bone marrow transplant, for the treatment of graft failure and delay of engraftment, and for the promotion of early engraftment. 03.05.1990 05.03.1991

Gallium nitrate injection Ganite Treatment of hypercalcemia of malignancy. 05.12.1988 17.01.1991

Coagulation Factor IX (human) AlphaNine

For use as replacement therapy in patients with hemophilia B for the prevention and control of bleeding episodes, and during surgery to correct defective hemostasis. 05.07.1990 31.12.1990

Epoetin alfa Epogen

Treatment of anemia associated with HIV infection or HIV treatment.

Treatment of AZT-induced anemia in HIV infected patients. 01.07.1991 31.12.1990

Altretamine Hexalen Treatment of advanced adenocarcinoma of the ovary.

Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or 09.02.1984 26.12.1990

Interferon gamma 1-b Actimmune Treatment of chronic granulomatous disease. 30.09.1988 20.12.1990

Calcium acetate Phos-Lo

Treatment of hyperphosphatemia in end stage renal failure. 22.12.1988 10.12.1990

Eflornithine HCl Ornidyl

Treatment of Trypanosoma brucei gambiense infection (sleeping sickness). 23.04.1986 28.11.1990

Citric acid, glucono-delta-lactone and magnesium carbonate Renacidin Irrigation

Treatment of renal and bladder calculi of the apatite or struvite variety. 28.08.1989 02.10.1990

Idarubicin HCl for injection Idamycin

Treatment of acute myelogenous leukemia, also referred to as acute nonlymphocytic leukemia. 25.07.1988 27.09.1990

Colfosceril palmitate, cetyl alcohol, tyloxapol Exosurf Neonatal for In

Treatment of established hyaline membrane disease at all gestational ages. 20.10.1989 02.08.1990

Colfosceril palmitate, cetyl alcohol, tyloxapol Exosurf Neonatal for In

as respiratory distress syndrome, in infants born at 32 weeks gestation or less. 20.10.1989 02.08.1990

Iobenguane Sulfate I 131For use as a diagnostic adjunct in patients with pheochromocytoma.

Adjunctive diagnostic agent in the localization of primary or metastatic pheochromocytomas. 14.11.1984 21.03.1990

Pegademase bovine Adagen

For enzyme replacement therapy for ADA deficiency in patients with severe combined immunodeficiency. 29.05.1984 21.03.1990

Botulinum toxin type A Botox

Treatment of strabismus associated with dystonia in adults (patients 12 years of age and above). 22.03.1984 29.12.1989

Botulinum toxin type A Botox

Treatment of blepharospasm associated with dystonia in adults (patients 12 years of age and above). 22.03.1984 29.12.1989

Cromolyn sodium Gastrocrom Treatment of mastocytosis. 08.03.1984 22.12.1989

Antithrombin III (human) ATnativ

For the treatment of patients with hereditary antithrombin III deficiency in connection with surgical or obstetrical procedures or when they suffer from thromboembolism. 08.02.1985 13.12.1989

Gonadorelin acetate Lutrepulse

For induction of ovulation in women with hypothalamic amenorrhea due to a deficiency or absence in the quantity or pulse pattern of endogenous GnRH secretion. 22.04.1987 10.10.1989

Ganciclovir sodium Cytovene

Treatment of cytomegalovirus retinitis in immunocompromised patients with AIDS. 31.10.1985 23.06.1989

Pentamidine isethionate Nebupent

Prevention of Pneumocystis carinii pneumonia in patients at high risk of developing this disease. 12.01.1988 15.06.1989

Selegiline HCl Eldepryl

As an adjuvant to levodopa and carbidopa treatment of idiopathic Parkinson's disease (paralysis agitans), postencephalitic Parkinsonism, and symptomatic Parkinsonism. 07.11.1984 05.06.1989

Epoetin alfa Epogen

Treatment of anemia associated with end stage renal disease. 10.04.1986 01.06.1989

Rifampin Rifadin I.V.

For antituberculosis treatment where use of the oral form of the drug is not feasible. 09.12.1985 25.05.1989

Mefloquine HCl Lariam

Prophylaxis of Plasmodium falciparum malaria which is resistant to other available drugs. 13.04.1988 02.05.1989

Mefloquine HCl Lariam

Treatment of acute malaria due to Plasmodium falciparum and Plasmodium vivax. 13.04.1988 02.05.1989

Ifosfamide Ifex Treatment of testicular cancer.

In combination with certain other approved antineoplastic agents, for third line chemotherapy in the treatment of germ cell testicular 20.01.1987 30.12.1988

Mesna Mesnex

For use as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis. 14.11.1985 30.12.1988

Ethanolamine oleate Ethamolin

Treatment of patients with esophageal varices that have recently bled, to prevent rebleeding. 22.03.1984 22.12.1988

Succimer Chemet capsules Treatment of lead poisoning in children. 09.05.1984 22.12.1988

Metronidazole (topical) Metrogel Treatment of acne rosacea. 22.10.1987 22.11.1988

Interferon alfa-2a (recombinant) Roferon-A Treatment of AIDS related Kaposi's sarcoma. 14.12.1987 21.11.1988

Interferon alfa-2b (recombinant) Intron A Treatment of AIDS-related Kaposi's sarcoma.Treatment of selected patients with AIDS-related Kaposi's sarcoma. 24.06.1987 21.11.1988

Leucovorin Leucovorin calcium

For rescue use after high dose methotrexate therapy in the treatment of osteosarcoma. 17.08.1988 31.08.1988

Tiopronin Thiola

Prevention of cystine nephrolithiasis in patients with homozygous cystinuria. 17.01.1986 11.08.1988

Methotrexate sodium Methotrexate Treatment of osteogenic sarcoma.

For the use of high dose methotrexate with leucovorin rescue in patients with non-metastatic osteosarcoma who have undergone surgical resection or 21.10.1985 07.04.1988

Benzoate and phenylacetate Ucephan

For adjunctive therapy in the prevention and treatment of hyperammonemia in patients with urea cycle enzymopathy due to carbamylphosphate synthetase, ornithine, transcarbamylase, or argininosuccinate 21.01.1986 23.12.1987

Mitoxantrone HCl Novantrone

Treatment of acute myelogenous leukemia, also referred to as acute nonlymphocytic leukemia. 13.07.1987 23.12.1987

Teriparatide Parathar

Diagnostic agent to assist in establishing the diagnosis in patients presenting with clinical and laboratory evidence of hypocalcemia due to either 09.01.1987 23.12.1987

Alpha1-proteinase inhibitor (human) Prolastin

For replacement therapy in the alpha-1-proteinase inhibitor congenital deficiency state.

For chronic replacement therapy of individuals having congenital deficiency of alpha1- proteinase inhibitor with clinically demonstrable 07.12.1984 02.12.1987

Pentastarch Pentaspan

As an adjunct in leukapheresis to improve the harvesting and increase the yield of leukocytes by centrifugal means. 28.08.1985 19.05.1987

Etidronate disodium Didronel

Treatment of hypercalcemia of malignancy inadequately managed by dietary modification and/or oral hydration. 21.03.1986 21.04.1987

Zidovudine Retrovir Treatment of AIDS. 17.07.1985 19.03.1987

Zidovudine Retrovir Treatment of AIDS related complex. 17.07.1985 19.03.1987

Somatropin for injection Humatrope

For the long-term treatment of children who have growth failure due to inadequate secretion of normal endogenous growth hormone. 12.06.1986 08.03.1987

Tranexamic acid Cyklokapron

Treatment of patients with congenital coagulopathies who are undergoing surgical procedures (e.g. dental extractions). 29.10.1985 30.12.1986

Clofazimine Lamprene

Treatment of lepromatous leprosy, including dapsone-resistant lepromatous leprosy and lepromatous leprosy complicated by erythema nodosum leprosum. 11.06.1984 15.12.1986

Calcitonin-human for injection Cibacalcin

Treatment of symptomatic Paget's disease (osteitis deformans). 20.01.1987 31.10.1986

Urofollitropin Metrodin

For induction of ovulation in patients with polycystic ovarian disease who have an elevated LH/FSH ratio and who have failed to respond to adequate clomiphene citrate therapy. 25.11.1987 18.09.1986

Digoxin immune FAB (Ovine) Digibind

Treatment of potentially life threatening digitalis intoxication in patients who are refractory to management by conventional therapy. 01.11.1984 22.04.1986

Levocarnitine Carnitor Treatment of genetic carnitine deficiency. 28.02.1984 10.04.1986

Trientine HCl Syprine

Treatment of patients with Wilson's disease who are intolerant, or inadequately responsive to penicillamine. 24.12.1984 08.11.1985

Monooctanoin Moctanin

For dissolution of cholesterol gallstones retained in the common bile duct. 30.05.1984 31.10.1985

Somatrem for injection Protropin

For long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion. 09.12.1985 17.10.1985

Somatropin Nutropin

For use in the long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion. 06.03.1987 17.10.1985

Potassium citrate Urocit-K

For avoidance of the complication of calcium stone formation in patients with uric lithiasis. 01.11.1984 30.08.1985

Potassium citrate Urocit-K

Prevention of calcium renal stones in patients with hypocitraturia. 01.11.1984 30.08.1985

Potassium citrate Urocit-K Prevention of uric acid nephrolithiasis. 01.11.1984 30.08.1985

Naltrexone HCl Trexan

For blockade of the pharmacological effects of exogenously administered opioids as an adjunct to the maintenance of the opioid-free state in detoxified formerly opioid-dependent individuals. 11.03.1985 30.11.1984

Pentamidine isethionate Pentam 300 Treatment of Pneumocystis carinii pneumonia. 28.02.1984 16.10.1984

Cromolyn sodium 4% ophthalmic solution Opticrom 4% ophthalmiTreatment of vernal keratoconjunctivitis. 24.07.1985 03.10.1984

Chenodiol Chenix

For patients with radiolucent stones in well opacifying gallbladders, in whom elective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. 21.09.1984 28.07.1983

Hemin Panhematin

Amelioration of recurrent attacks of acute intermittent porphyria (AIP) temporarily related to the menstrual cycle in susceptible women and similar symptoms which occur in other patients with AIP, porphyria 16.03.1984 20.07.1983

(+/-)-7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-

Prevention of serious adverse events associated with vascular leak syndrome caused by Interleukin-2 therapy 31.03.2003

(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-cromen-7-ol

Treatment of Stage IIB through Stage IV malignant melanoma 01.02.2008

(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-cromen-7-ol Treatment of pancreatic cancer 10.01.2008(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-cromen-7-ol Treatment of cholangiocarcinoma 10.01.2008(1R,2R)-Octanoic acid [2-(2',3'-dihydrobenzo[1,4]dioxin-6'-yl)-2-hydroxy-l-pyrrolidin-1-ylmethyl- Treatment of Gaucher disease 17.09.2008(1R,2S) 6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-(1-naphthyl)-beta-phenyl-3-quinolineethanol Treatment of pulmonary tuberculosis (active disease) 10.01.2005(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride

Treatment of chronic lymphocytic leukemia and related leukemias to include prolymphocytic leukemia, adult T-cell leukemia, and hairy cell leukemia 10.08.2004

(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride Treatment of acute lymphoblastic leukemia 13.08.2004(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol- Treatment of T-cell non-Hodgkin's lymphoma 29.01.2004(2Z)-2-cyano-3-3hydroxy-N-[4-(trifluoromethly)phenyl]-2-hepten-6- FK778

Prevention of acute rejection following kidney, heart, and liver tranplantation 10.01.2005

(3S)-3-(4-trifluoromethoxybenzyloxy)-6-nitro-2H-3,4-dihydroimidazo[2,1- Treatment of tuberculosis. 05.07.2007

(3S)-3-[(2S)-2-({N-[2-tert-butyl)phenyl]carbamoyl}carbonylamino) propanoylamino]-4-oxo-5-

Treatment of patients undergoing solid organ transplantation. 19.08.2003

(4S)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1-H-pyrano[3?,4?:6,7]-indolizino-[1,2-b]-Gimatecan Treatment malignant glioma 29.11.2002

(6R,S)5,10-methylene-tetrahydrofolic acid CoFactor

For use in combination with 5-fluorouracil for the treatment of patients with pancreatic cancer 13.08.2004

(9-[N-(3-morpholinopropyl)-sulfonyl]-5,6-dihydro-5-oxo-11-H-

Prevention of post-operative complications of aortic anuerysm surgical repair 08.12.2004

(R)-2-methyl-6-nitro-2-{4-[4-(4-trifluoromethoxyphenoxy)piperidin-1-yl]phenoxymethyl}-2,3- Treatment of pulmonary tuberculosis. 12.07.2007(R)-4-(3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(4-{4-[2-(4-chlorophenyl)-5,5- Treatment of small cell lung cancer 19.12.2007(R)-4-(3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(4-{4-[2-(4-chlorophenyl)-5,5- Treatment of multiple myeloma 05.05.2008(R)-4-(3-morpholin-4-yl-l-phenylsulfanylmenthyl-propylamino)-N-(4-{4-[2-(4-chlorophenyl)-5,5- Treatment of chronic lymphocytic leukemia 19.12.2007

(R)-N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide

Treatment of circadian rhythm sleep disorders in blind people with no light perception 03.10.2001

(R)-N-[2-(6-Chloro-methoxy-1H-indol-3yl)propyl]acetamide

Treatment of neuroleptic-induced tardive dyskinesia in schizophrenia patients 03.07.2003

(s)-3'-(HO)-DADFT-PETreatment of chronic iron overload in patients with transfusion-dependent anemias 04.02.2009

(UDU-stereoisomer of c-UJUun UNU-terminal UkUnhibitor) Treatment of acute sensorineural hearing loss 28.03.2006

(Z-8-methyl-N-vanillyl-6-nonnamide) ; Civamide Treatment of postherpetic neuralgia. 17.02.2009[131I]-N-(2-(diethylamino) ethyl-4-(4 flurobenzamido)-5-(iodo)-2-methoxybenzamide

Treatment of metastatic melanoma, stages IIB, IIC, III and IV 17.09.2008

[5,10,15,20-tetrakis(1,3-diethylimidazolium-2-yl)porphyrinato] Treatment of Amyotrophic Lateral Sclerosis 04.11.2003

[Lu-177]-DOTA-Tyr3-OctreotateTreatment of gastro-entero-pancreatic neuroendocrine tumors 12.01.2009

[Nle4, D-Phe7]-a-melanocyte stimulating hormone Treatment of erythropoietic porphyrias 17.07.2008

1,5-(Butylimino)-1,5 dideoxy,D-glucitol Treatment of Fabry's disease. 12.05.199811-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.12,6.18,12}hepta

For treatment of myeloproliferative disorders (MPD) with the JAK2 V617F mutation. 13.03.2008

111Indium pentetreotide SomatoTher

Treatment of somatostatin receptor positive neuroendocrine tumors. 10.06.1999

166Ho-DOTMP Treatment of multiple myeloma. 10.02.1999

17 a-Hydroxyprogesterone caproate Gestiva Prevention of preterm birth in singleton pregnancies 25.01.200717-allylamino-17-demethoxygeldanamycin (17-AGG) For the treatment of chronic myelogenous leukemia. 03.09.2004

1-Deoxygalactonojirimycin Treatment of Fabry Disease 25.02.2004

1-dexynojirimycin hydrochloride Treatment of Pompe disease 18.06.2007

2 dimethylbutyrate Treatment of beta thalassemia 18.06.20082-(2-phenylvinyl)-4-[4-methylpiperazin-l-yl)]-6-(5-methyl-2H-pyrazol-3-yl-amino)-pyrimidine Treatment of multiple myeloma. 22.12.20082-(2-phenylvinyl)-4-[4-methylpiperazin-l-yl)]-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidine Treatment of ovarian carcinoma 18.03.20092-(3,5-dichloro-phenyl)-benzoxazole-6-carboxylic acid Treatment of familial amyloid polyneuropathy 23.05.2006

2-(3-diethylaminopropyl)-8,8-dipropyl-2-azaspiro [4,5] decan dimaleate Atiprimod

Treatment of mulitple myeloma and associated bone resorption 02.12.2003

2-(3-Diethylaminopropyl)-8,8-dipropyl-2-azaspiro[4,5] decane dimaleate Atiprimod Treatment of carcinoid tumors 18.09.2006

2',3',5'-tri-o-acetyluridine Treatment of mitochondrial disease 13.01.20032,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6R)-; (6R)-4,5,6,7-tetrahydro-N6- Treatment of amyothrophic lateral sclerosis (ALS). 11.10.20072-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)methylsulfinyl] -1H- PreVonco (tm) Treatment of hepatocellular carcinoma. 27.08.2008

2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimadazole-4-carboxamide

Treatment of malignant melanoma stages IIb through IV. 18.12.2007

2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimadazole-4-carboxamide

Treatment glioblastoma multiforme when used in combination with DNA-damaging agents 09.05.2008

2-0-Butyryl-1-0-octyl-myo-inositol 3,4,5,6-tetrakisphosphate Treatment of cystic fibrosis 15.08.2003

2-0-desulfated heparin Aeropin Treatment of cystic fibrosis. 17.09.1993

20-mer complementary to Akt mRNA Treatment of stomach cancer 10.12.2004

20-mer oligonucleotide complementary to Akt mRNA Treatment of pancreatic cancer 08.12.2004

20-mer oligonucleotide complementary to Akt mRNA Treatment of glioblastoma 08.12.200420-mer oligonucleotide complementary to Akt mRNA Treatment of renal cell carcinoma 01.12.2004

20-mer oligonucleotide complementary to Akt mRNA Treatment of ovarian cancer 01.12.2004

2'-3'-dideoxyadenosine Treatment of aquired immunodeficiency syndrome. 21.07.1987

24,25 dihydroxycholecalciferol Treatment of uremic osteodystrophy. 27.02.1987

2-chloroethyl-3-sarcosinamide-1-nitrosourea Treatment for malignant gliomas 03.08.2001

2-chloroethyl-3-sarcosinamide-1-nitrosourea Sarmustine Treatment for malignant glioma 15.11.2001

2'-deoxycytidineAs a host-protective agent in the treatment of acute myelogenous leukemia. 09.09.1996

2-iminobiotin Treatment of perinatal asphyxia. 24.02.2009

2-methoxyestradiol PulmoLAR Treatment of pulmonary arterial hypertension 11.04.2005

2-methoxyestradiol Panzem NCD Treatment of ovarian cancer 04.04.2005

2-methoxyestradiol Panzem Treatment of multiforme glioblastoma 16.06.2006

2-methoxyestradiol Panzem Treatment of multiple myeloma 10.07.2001

2'-O-methyl-phosphorothiolate oliogribonucleotide Treatment of Duchenne muscular dystrophy 18.11.2005

3-(3,5-Dimethyl-1H-2ylmethylene)-1,3-dihydro-indol-2-one Treatment of von Hippel-Lindau disease. 23.03.2000

3-(3,5-dimethyl-1H-2ylmethylene)-1,3-dihydro-indol-2-one Treatment of Kaposi's sarcoma. 11.09.1998

3,4-diaminopyridine Treatment of Lambert-Eaton myasthenic syndrome. 18.12.1990

3,5,3'-triiodothyroacetate

Treatment of well-differentiated papillary, follicular or combined papillary/follicular carcinomas of the thyroid gland. 20.09.2000

3-[5-(2-fluoro-plhenyl)-[1,2,4]oxadiazole-3-yl]benzoic acid

Treatment of Muscular Dystrophy resulting from premature stop mutations in the dystrohin gene 10.01.2005

3-[5-(2-fluoro-plhenyl)-[1,2,4]oxadiazole-3-yl]benzoic acid

For use in the treatment of cystic fibrosis resulting fron a nonsense (premature stopcodon) mutation in the cystic bibrosis transmembrane conductance regulatory 01.09.2004

3-[5-(2-fluoro-plhenyl)-[1,2,4]oxadiazole-3-yl]benzoic acid Treatment of spinal muscular atrophy. 10.03.2008

3'-azido-2',3'dideoxyuridine AZDU Treatment of acquired immunodeficiency syndrome. 20.11.1989

3-fluoro-5-[5-(2-menthyl-thiazol-4-ylethylnyl)-pyridin-2-yl]-benzonitrile dihydrochloride

Treatment of behavioral abnormalities associated with fragile X syndrome. 28.07.2008

4-(2-fluorophenyl)-6-methyl-2-(1-piperzinyl)

Treatment of Chronic Functional Vomiting to include functional vomiting and cyclic vomiting syndrome. 11.10.2006

4-(3-Methanesulfonyl-phenyl)-1-propylpiperidine HCl Treatment of Huntington disease. 12.12.20054, 5 dibromorhodamine methyl ester Theralux PhotodynamicTreatment of follicular lymphoma 30.10.2008

4, 5 dibromorhodamine methyl ester Theralux PhotodynamicTreatment of diffuse large B-cell lymphoma 30.10.2008

4,5 dibromorhodamine methyl ester Theralux Photodynamic

For immune reconstitution and prevention of graft versus host disease following allogeneic hematopoietic stem cell transplantation. 23.10.2007

4,5-dibromorhodamine 123 Theralux Irradiation DeTreatment of chronic myelogenous leukemia 10.04.20034,6,8-trihydroxy-10-(3,7,11-trimethyldodeca-2,6,10-trienyl)- Treatment of malignanat glioma 27.04.20094-[[[4-(4-Chlorophenoxy)phenyl]sulfonyl]-

Prophylaxis of organ rejection in patients receiving allogeneic liver transplants 18.06.2008

4-[1]benzofuro[3,2-d]pyrimidin-4-yl-N-(1,3-benzodioxol-5-ylmethyl)piperazine-1-

Treatment, in combination with radiotherapy and temozolomide chemotherapy, of patients with glioblastoma multiforme. 30.07.2008

40SD02

Treatment of chronic iron overload resulting from conventional transfusional treatment of beta-thalassemia major and sickle cell anemia. 21.12.1998

4-Amino-1-[5-O-[(2R, 4S)-2-oxido-4-(4-pyridinyl)-1, 3, 2-dioxaphosphorinan-2-yl]-b-D- Treatment of hepatocellular carcinoma. 22.08.2007

4-AminopyridineTreatment chronic functional motor and sensory deficits from Guillain-Barre syndrome 14.12.2005

4-aminosalicylic acid Paser Granules

Treatment of acute flares in pediatric patients with ileo-cecal Crohn's disease 26.04.2006

4-aminosalicylic acid Pamisyl (P-D), Rezipas

Treatment of mild to moderate ulcerative colitis in patients intolerant to sulfasalazine. 13.12.1989

4-cholest-en-3-one, oxime Treatment of amyotrophic lateral sclerosis 01.12.20054-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2- Treatment of acute myeloid leukemia 20.07.20064-trifluoromethyl-N-(3.3a.4.4a.5,5a,6,6a-octahydro-1,3-dioxo- Treatment of smallpox. 27.12.20064-trifluoromethyl-N-(3.3a.4.4a.5,5a,6,6a-octahydro-1,3-dioxo- post exposure prophylaxis against smallpox 18.12.2006

5(S)-(2'-hydroxy ethoxy)-20(S)-Camptothecin Treatment of osteosarcoma (bone cancer) 15.06.20075,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-a-L-lyxo- Treatment of malignant gliomas 11.10.20065,5',5"-[Phosphinothioylidyne-tris(imino-2,1-ethanediyl)]tris[5-methylchelidoninium]trihydroide Treatment of pancreatic cancer 20.08.2003

5,6-dihydro-5-azacytidine Treatment of malignant mesothelioma. 11.05.1992

5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one Prevention of acute radiation syndrome 18.06.2007

5-[(E)-2-(4-hydroxyphenyl)-ethenyl] benzene-1,3 diol Resveratrol Treatment of MELAS syndrome 13.03.2008

506U78 Treatment of chronic lymphocytic leukemia. 02.09.1999

5a8, monoclonal antibody to CD4For use in post-exposure prophylaxis for occupational exposure to human immunodeficiency virus. 20.12.1993

5-aza-2'-deoxycytidine Treatment of acute leukemia. 03.08.1987

5-Azacitidine Vidaza Treatment of acute myeloid leukemia 18.06.2008

5-hydroxymethyl-2-furfuraldehyde Treatment of sickle cell disease 26.05.20065-iodo-2-pytimidinone-2'-deoxyribose Treatment of malginant glioma 26.05.2006

5-methyl-1-phenyl-2-(1H)-pyridone(CAS 53179-13-8) Pirfenidone Treatment of idiopathic pulmonary fibrosis 05.03.2004

5'-O-(trans-9''-octadecenoyl)-1-B-D-arabinofuranosyl cytosine Treatment of acute myeloid leukemia. 18.06.2008

6 alpha-ethylchenodeoxycholic acid Treatment of primary biliary cirrhosis 09.04.20086,8-bis-benzylsulfanyl-octanoic acid Treatment of pancreatic cancer 06.02.20066-alpha-ethylchenodeoxycholic acid Treatment of primary sclerosing cholangitis 09.04.2008

6-hydroxymethylacylfulveneTreatment of histologically confirmed advanced or metastatic pancreatic cancer. 06.04.1999

8-methoxsalen Uvadex

For use in conjunction with the UVAR photopheresis to treat diffuse systemic sclerosis. 22.06.1993

8-methoxsalen Uvadex

For the prevention of acute rejection of cardiac allografts. 12.05.1994

90Y-hPAMA4 PAN-Cide Treatment of pancreatic cancer 29.01.2004

9-cis-retinoic acidPrevention of retinal detachment due to proliferative vitreoretinopathy. 02.01.1997

9-nitro-20-(S)-camptothecin Treatment of pancreatic cancer. 16.09.1996

9-nitro-20-(S)-camptothecin Camvirex Treatment of pediatric HIV infection/AIDSTreatment of pediatric HIV-infection/AIDS patients 15.05.2001

a-(3-aminophthalimido) glutaramide Actimid Treatment of multiple myeloma 15.01.2003

A10 & AS2-1 Antineoplaston Treatment for patients with brain stem glioma 03.09.2004

AAV2-hRPE65v2Treatment of Leber congenital amaurosis due to RPE65 mutations. 24.06.2008

Abetimus Treatment of lupus nephritis. 28.07.2000

ACA125 Treatment of epithelial ovarian cancer 25.11.2003

Acetylcysteine Mucomyst/Mucomyst 1

Intravenous treatment of patients presenting with moderate to severe acetaminophen overdose. 13.08.1987

Acid sphingomyelinaseTreatment of acid sphingomyelinase deficiency (Niemann-Pick disease). 03.08.2000

Adalimumab Humira Treatment of pediatric Crohn's disease. 19.10.2006Adeno-associated vector expressing the human lipoprotein lipase protein Treatment of lipoprotein lipase deficiency 21.05.2007Adeno-associated viral vector containing the gene for human coagulation factor IX Coagulin-B

Intramuscular treatment of patients with moderate to severe hemophilia 13.06.2001

Adeno-associated viral vector containing the gene for human coagulation factor IX Coagulin-B

Intrahepatic treatment of patients with moderate to severe hemophilia 13.06.2001

Adeno-associated viral vector expressing human acid alpha glucosidase gene Treatment of Pompe disease 20.03.2007

adeno-associated viral vector expressing human retinoschisin-1 gene Treatment of X-linked juvenile retinoschisis (XLRS). 21.05.2007Adeno-associated viral vector serotype 5 containing human ABCA4 gene Treatment of Stargardt's disease. 30.09.2008

Adeno-associated viral-based vector cystic fibrosis gene therapy Treatment of cystic fibrosis. 15.02.1995

AdenosineFor use in conjunction with BCNU in the treatment of brain tumors. 01.08.1989

Adenoviral vector expressing Herpes simplex virus thymidine kinase gene Treatment of malignant brain tumors 17.06.2005Adenovirus-based vector Factor VIII complementary DNA to somatic cells MiniAdFVIII Treatment of hemophilia A. 15.12.1999adenovirus-mediated herpes simplex virus-thymidine kinase gene

Use with gancyclovir in the treatment of malignant glioma 31.07.2001

Aerosolized pooled immune globulin

Treatment of respiratory syncytial virus lower respiratory tract disease. 03.01.1989

a-Galactosidase A Plant-Produced HumanTreatment of Fabry's disease 21.01.2003

Aglycosyl anti-CD3 monoclonal antibody Treatment of new-onset type I diabetes mellitus 06.02.2006

AI-RSA Treatment of autoimmune uveitis. 08.10.1992

Albuterol Prevention of paralysis due to spinal cord injury 12.03.2002

ALD-101

To improve patient outcomes by decreasing time to platlet and neutrophil engraftment in patients with inherited metabolic diseases (IMD) undergoing 23.10.2008

Aldesleukin Proleukin

Treatment of primary immunodeficiency disease associated with T-cell defects. 22.03.1989

Aldesleukin Proleukin Treatment of acute myelogenous leukemia. 31.07.1998

Aldesleukin Proleukin For the treatment non-Hodgkin's lymphoma. 24.11.1998

Alefacept Amevive

For use as prophylaxis of rejection in patients receiving allogenic solid organ transplants. 19.12.2007

alendronate Fosamax

Treatment of osteogenesis imperfecta in pediatric patients 4 years of age and older 31.03.2003

Alendronate disodium Fosamax

Treatment of the bone manifestations of Gaucher disease 13.02.2001

Alfentanil Management of postherpetic neuralgia 08.07.2005

Alfentanil Treatment of painful HIV-associated neuropathy 09.08.2005

Alglucerase injection Ceredase

Replacement therapy in patients with Type II and III Gaucher's disease. 21.07.1995

alicaforsen Treatment of pouchitis. 24.06.2008

Alitretinoin Panretin Treatment of acute promyelocytic leukemia 10.04.1992

allantoin Alwextin

Treatment of skin blistering and erosions associated with inherited epidermolysis bullosa 21.11.2002

Allogeneic human aortic endothelial cells cultured in a porcine gelatin matrix Vascugel (r)

Prevention of arteriovenous fistula or arteriovenous graft failure in patients with end satge renal disease receiving hemodialysis or preparing for hemodialysis 03.04.2009

Allogeneic human retinal pigment epithelial cells on gelatin microcarriers Spheramine

Treatment of Hoehn and Yahr stage 3 and 4 Parkinson's disease. 18.07.1997

allogeneic mesenchymal precursor cells derived from ex vivo healthy donors harvested

Treatment of insufficient hematopoietic stem cell production in patients with hematologic malignancies who have failed treatment with conventional chemotherapy. 12.09.2008

Allogeneic peripheral blood mononuclear cells sensitized against patient alloantigens by CYTOIMPLANT Treatment of pancreatic cancer 13.06.1997Allogeneic retinal epithelial cells transfected with plasmid vector expressing ciliary neurotrophic Treatment of retinitis pigmentosa 01.09.2004Allogeneic T-cells cultured with anti-CD3 and IL-2; transduced with retroviral vector (SFCMM-3),

Immunotherapy for acceleration of T-cell reconstitution in patients undergoing allogeneic hematopoietic stem cell transplantation

28.01.2005

Allopurinol riboside Treatment of cutaneous and visceral leishmaniasis. 04.12.1985

Allopurinol riboside Treatment of Chagas' disease. 04.12.1985

Allopurinol sodiumEx-vivo preservation of cadaveric kidneys for transplantation 09.11.1987

Alpha-1-acid glycoprotein Treatment of cocaine overdose 05.03.2004

Alpha-1-acid glycoprotein Treatment of tricyclic antidepressant poisoning 17.03.2004

Alpha-1-antitrypsin (recombinant DNA Origin)

As supplementation therapy for alpha-1-antitrypsin deficiency in the ZZ phenotype population. 01.01.1984

Alpha1-antitrypsin(human) Treatment of bronchiectasis 03.04.2008

Alpha1-Proteinase Inhibitor (Human)

Inhalation therapy for the the treatment of congential deficiency of alpha1-proteinase inhibitor. 22.12.2004

Alpha1-Proteinase Inhibitor (Human) ARC-API Treatment of cystic fibrosis 01.09.2004

alpha1-proteinase inhibitor (human) Treatment of cystic fibrosis 20.02.2009

Alpha1-proteinase inhibitor (human)

For slowing the progression of emphysema in alpha1-antitrypsin deficient patients. 24.11.1999

Alpha-galactosidase A Fabrase Treatment of Fabry's disease. 20.07.1990

Alpha-galactosidase A CC-galactosidase

Treatment of alpha-galactosidase A deficiency (Fabry's disease). 17.06.1991

Alpha-galactosidase A Replagal

Long-term enzyme replacement therapy for the treatment of Fabry disease. 22.06.1998

Alpha-melanocyte stimulating hormone

Prevention and treatment of intrinsic acute renal failure due to ischemia. 19.08.1997

Alpha-tocopherol quinoneTreatment of inherited mitochondrial respiratory chain diseases 28.03.2006

Alprostadil

Treatment of severe peripheral arterial occlusive disease (critical limb ischemia) in patients where other procedures, grafts or angioplasty, are not indicated. 20.10.1993

alteplase Activase

Treatment of intraventricular hemmorage associated with intracerebral hemmorrhage 27.01.2003

AlvocidibTeatment of B-cell chronic lymphocytic leukemia (B-CLL) or prolymphocytic leukemia arising from CLL. 13.04.2007

ALX-0081 nanobody, directed towards the human A1 domain of von Willebrand factor Treatment of thrombotic thrombocytopenic purpura 14.04.2009

AMG 531Treatment of thrombocytopenia associated with myelodysplasia syndrome 31.10.2007

Amifostine Ethyol Treatment of myelodysplastic syndromes. 04.10.1999

Amifostine Ethyol

For use as a chemoprotective agent for cisplatin in the treatment of metastatic melanoma. 30.05.1990

Amifostine Ethyol

cyclophosphamide in the treatment of advanced ovarian carcinoma. 30.05.1990

Amifostine Ethyol

For the reduction of the incidence and severity of toxicities associated with cisplatin administration. 24.11.1998

Amikacin SLIT Amikacin

Treatment of bronchopulmonary Pseudomonas aeruginosa infections in cystic fibrosis patients 09.03.2006

Amiloride HCl solution for inhalation Treatment of cystic fibrosis. 18.07.1990

Aminocaproic acid Caprogel

For the topical treatment of traumatic hyphema of the eye. 06.01.1995

Aminolevulinic acid hydrochloride Levulan Treatment of esophageal dysplasia 20.03.2007

Aminosalicylate sodium Treatment of Crohn's disease. 06.04.1993

Aminosidine Paromomycin Treatment of visceral leishmaniasis 29.03.2005

Aminosidine Paromomycin Treatment of visceral leishmaniasis (kala-azar). 09.09.1994

Aminosidine Gabbromicina Treatment of tuberculosis. 14.05.1993

Aminosidine Gabbromicina Treatment of Mycobacterium avium complex. 15.11.1993

Amiodarone Amio-Aqueous Treatment of incessant ventricular tachycardia. 17.08.1993

ammonium tetrathiomolybdate Treatment of idiopathic pulmonary fibrosis 05.05.2008

Ammonium tetrathiomolybdate Coprexa Treatment of Wilson's disease. 31.01.1994

Amonafide L-malate Xanafide Treatment of acute myeloid leukemia 20.12.2006

Amphotericin B inhalation powder

Prevention of pulmonary fungal infections in patients at risk for aspergillosis due to immunosuppressive therapy including those receiving organ or stem cell transplants, or teated with chemotherapy or radiation for 15.12.2005

Amphotericin B lipid complex Abelcet Treatment of invasive protothecosis. 21.08.1996

Amphotericin B lipid complex Abelcet Treatment of invasive sporotrichosis. 23.09.1996

Amphotericin B lipid complex Abelcet Treatment of invasive coccidioidomycosis. 06.05.1996

Amphotericin B lipid complex Abelcet Treatment of invasive zygomycosis. 06.05.1996

Amphotericin B lipid complex Abelcet Treatment of invasive candidiasis. 27.06.1996

amrubicin Treatment of small cell lung cancer 10.03.2008

Amsacrine Amsidyl Treatment of acute adult leukemia. 07.12.1984

Amyl nitrite, sodium nitrite, sodium thiosulfate Cyanide Antidote Kit Treatment of cyanide poisoning 18.12.2006

Anagrelide Agrylin

Treatment of thrombocytosis in chronic myelogenous leukemia. 14.07.1986

Anagrelide Agrylin Treatment of polycythemia vera. 11.06.1985

Ananain, comosain Vianain For the enzymatic debridement of severe burns. 21.01.1992

Anaritide acetate Auriculin Treatment of patients with acute renal failure. 27.08.1992

Anaritide acetate Auriculin

Improvement of early renal allograft function following renal transplantation. 10.04.1992

Anatibant

Treatment of patients having experienced a severe traumatic brain injury (Glasgow Coma Scale 3 to 8) in order to decrease early mortality and improve long-term functional and neurological outcome 15.04.2005

Ancrod Viprinex

To establish and maintain anticoagulation in heparin-intolerant patients undergoing cardiopulmonary bypass.

20.10.1989

Angiotensin 1-7 MARstem Treatment of myelodysplastic syndrome 03.08.2001

Angiotensin 1-7Treatment of neutropenia associated with autologous bone marrow transplantation. 16.02.2000

anthrax immune globulin (human)Treatment of toxemia associated with inhalational anthrax. 29.07.2008

anti human Nogo-A human monoclonal antibody Treatment of acute spinal cord injury 20.10.2008Anti pan T lymphocyte monoclonal antibody Anti-t Lymphocyte Imm

For ex-vivo treatment to eliminate mature T cells from potential bone marrow grafts. 29.01.1986

Anti pan T lymphocyte monoclonal antibody Anti-t Lymphocyte Imm

For in-vivo treatment of bone marrow recipients to prevent graft rejection and graft versus host disease. 29.01.1986

antiangiogenic components extracted from marine cartilage Neovastat (AE-941) Treatment of renal cell carcinoma 16.10.2002anti-CD23 IgG1, kappa monoclonal antibody Treatment of chronic lymphocytic leukemia 12.02.2003

anti-CD30 Fc engineered humanized monoclonal antibody Treatment of Hodgkin lymphoma 02.12.2008

Anti-CD40 mAb Treatment of chronic lymphocytic leukemia 06.10.2005

Anti-CD45 monoclonal antibodiesPrevention of acute graft rejection of human organ transplants. 10.09.1990

Anti-CEA Sheep-human chimeric monoclonal antibody labeled w/iodine-131 (KAb201) Treatment of pancreatic cancer 21.05.2003

Anti-cytomegalovirus monoclonal antibodies

Prevention of human cytomegalovirus infection in bone marrow and organ transplant patients. 02.05.1990

Anti-cytomegalovirus monoclonal antibodies

Treatment of human cytomegalovirus infection in bone marrow and organ transplant patients. 02.05.1990

Anti-cytomegalovirus monoclonal antibodies

Prevention of human cytomegalovirus infection in patients diagnosed with AIDS. 03.05.1990

Anti-cytomegalovirus monoclonal antibodies

Treatment of human cytomegalovirus infection in patients diagnosed with AIDS. 03.05.1990

Anti-cytotoxic T lymphocyte antigen 4 monoclonal antibody Treatment of stage IIb to stage IV metastatic melanoma 18.09.2006

AntiepilepsirineTreatment of drug resistant generalized tonic-clonic epilepsy in children and adults. 23.03.1989

Antihemophilic factor (recombinant) formulated with sucrose reconstituted with Kogenate(r) FS Treatment of hemophilia A 29.04.2009

anti-interferon-gamma Fab from goats

For the treatment of immunologic corneal allograft rejection 18.11.2003

Antimelanoma Antibody XMMME-001-DTPA 111 Indium Antimelanoma Antibody

Diagnostic use in imaging systemic and nodal melanoma metastasis. 14.11.1984

Antimelanoma Antibody XMMME-001-RTA Antimelanoma Antibody

Treatment of stage III melanoma not amenable to surgical resection. 14.11.1984

antineoplaston A10, antineoplaston AS2-1 Treatment of gliomas 30.10.2008

Antipyrine TestFor use as an index of hepatic drug-metabolizing capacity. 21.02.1985

Antisense 20-mer oligonucleotide complementary to R2 component Treatment of acute myeloid leukemia 15.04.2005antisense 20-mer phosphorothioate oligonucleotide [complementary to the coding GTI-2040 Treatment for renal cell carcinoma 12.03.2003

Antisense inhibitor of apoB-100 Treatment of homozygous familial hypercholesterolemia 23.05.2006

Antisense oligonucleotide directed against connexin43 Nexagon Treatment of persistent corneal epithelial defects 27.04.2009

Anti-T cell receptor murine monoclonal antibody

Prophylaxis of acute rejection of solid organ transplantation 03.04.2009

Anti-tap-72 immunotoxin Xomazyme-791 Treatment of metastatic colorectal adenocarcinoma. 06.03.1987

Anti-tenascin 81C6 monoclonal antibody labeled w/ I 131 Neuradiab Treatment of primary malignant brain tumors 04.10.2005

Antithrombin III (human) concentrate IV Kybernin P

For prophylaxis and treatment of thromboembolic episodes in patients with genetic AT-III deficiency. 02.07.1985

Antithrombin III human Antithrombin III human

Preventing or arresting episodes of thrombosis in patients with congenital AT-III deficiency and/or to prevent the occurrence of thrombosis in patients with 02.01.1986

Anti-thymocyte Globulin (Rabbitt) Thymoglobulin Treatment of myelodysplastic syndrome (MDS) 06.09.2000

Anti-thymocyte serum Nashville Rabbit Anti-th

Treatment of allograft rejection, including solid organ (kidney, liver, heart, lung, and pancreas) and bone marrow transplantation. 02.06.1993

anti-T-lymphocyte immune globulin, rabbit

Prophylaxis of acute allograft rejection in adult recipients in solid organ transplantation. 12.09.2008

Antivenin crotaline (pit-viper) equine immune F(ab)2) Antivipmyn Treatment of envenomation by Crotaline snakes 29.01.2004

Antivenom (crotalidae) purified (avian)

Treatment of envenomation by poisonous snakes belonging to the Crotalidae family. 12.02.1991

Anti-von Willebrand Aptamer Treatment of thrombotic thrombocytopenic purpura 09.04.2008

AP1903Treatment of acute graft-versus-host disease in patients undergoing bone marrow transplantation. 24.11.1999

APL 400-020 V-Beta DNA vaccine Treatment of cutaneous T cell lymphoma. 08.03.1995

ApomorphineFor use as rescue treatment for early morning motor dysfunction in late-stage Parkinson's disease. 20.10.1997

ApomorphineTreatment of the on-off fluctuations associated with late-stage Parkinson's disease. 17.07.1995

Apomorphine hydrochloride

For the treatment of patients in a vegetative state or minimally conscious state for up to 12 months following a severe traumatic brain injury (traumatic or 23.05.2006

AQ-13 (4-aminoquinoline analog) Treatment of malaria 12.09.2008

Arcitumomab 99m Tc-labeled CEA-S

Diagnosis and localization of primary, residual, recurrent and metastatic medullary thyroid carcinoma. 10.05.1996

Arenegyr Treatment of malignant plueral mesothelioma 22.08.2008

Arginine butyrate Treatment of sickle cell disease and beta thalassemia. 25.05.1994

Arginine butyrateTreatment of beta-hemoglobinopathies and beta-thalassemia. 07.04.1992

arimoclomol Treatment of amyotrophic lateral sclerosis 29.03.2005

Aripiprazole Abilify Treatment of Tourette's syndrome 25.01.2006

arsenic Trisenox

Treatment of acute myelocytic leukemia subtypes M0, M1, M2, M4, M5, M6 and M7 02.11.2001

Arsenic trioxide Trisenox Treatment of malignant glioma 04.03.2005

arsenic trioxide Trisenox Treatment of chronic myeloid leukemia 18.10.2001

Arsenic trioxide Trisenox Treatment of multiple myeloma. 28.04.2000

arsenic trioxide Trisenox Treatment of liver cancer 13.06.2003

Arsenic trioxide Trisenox Treatment of chronic lymphocytic leukemia 13.05.2003

arsenic trioxide Trisenox Treatment of myelodysplastic syndrome. 17.07.2000

artemether/lumefantrine Coartem

For the treatment of infections due to Plasmodium falciparum or mixed infections including P. falciparum. 31.08.2007

Artesunate Treatment of malaria. 19.07.1999

Artesunate Immediate treatment of malaria 28.03.2006

arylsulfatase A (rhARSA) Treatment of metachromatic leukodystrophy. 27.02.2008

As-101 Treatment of acquired immunodeficiency syndrome. 09.11.1987

Ascorbic acid Ascor L 500 Treatment of scurvy 31.08.2007

Atomoxetine hydrochloride STRATTERA Treatment of Tourette's Syndrome 26.08.2003

Atovaquone Mepron

Primary prophylaxis of HIV-infected persons at high risk for developing Toxoplasma gondii encephalitis. 16.03.1993

Atovaquone Mepron

Treatment and suppression of Toxoplasma gondii encephalitis. 16.03.1993

Attenuated autologous cancer cells and granulocyte macrophage colony stimulating factor in

Treatment of primary central nervous system malignancies 27.04.2007

autologous antigen presenting cells pulsed with autologous tumor Mylovenge Treatment of multiple myeloma 18.04.2002Autologous cultured endothelial cells on a donor human corneal disk

Treatment of Fuch's dystrophy, pseudophakic bullous keratopathy, and bullous keratopathy 01.06.2007

Autologous dendritic cells pulsed with autologous antigens from primay malignant brain tumor cells DCVax-Brain Treatment of primary brain malignant cancer 29.11.2002Autologous DNP-conjugated tumor vaccine M-Vax

For adjuvant therapy in melanoma patients with surgically resectable lymph node metastasis (Stage III and limited Stage IV disease). 23.02.1999

Autologous incubated macrophageTherapy to improve the motor and sensory neurological outcome in acute cases of spinal cord injury 03.09.2004

autologous lymphocytes depleted ex vivo of immunoreactive T cells Theralux photodynamicTreatment of chronic graft versus host disease 03.04.2008

autologous olfactory neural progenitors RhinoCytes Treatment of amyotrophic lateral sclerosis 31.12.2008

Autologous olfactory neural progenitors RhinoCytes

Treatment of spinal cord injury patients with ASIA Impairment grades A, B, or C 01.02.2008

Autologous or allogeneic limbal epithelial stem cells expanded ex vivo on human amniotic

Treatment of ocular surface diseases that are characterized by total limbal stem cell deficiency 14.07.2005

autologous tumor-derived gp96 heat shock protein-peptide complex Oncophage Treatment of renal cell carcinoma 10.05.2002autologous tumor-derived gp96 heat shock protein-peptide complex Oncophage Treatment of metastatic melanoma 11.07.2002

Autolymphocyte therapy Treatment of renal cell carcinoma. 12.07.1994

aviptadil Treatment of pulmonary arterial hypertension 22.02.2005

axitinib Treatment of pancreatic cancer 31.05.2007

Azathioprine Imuran

Treatment of oral manifestations of graft-versus-host disease. 14.09.1999

aztreonamInhalation therapy for control of gram-negative bacteria in the respiratory tract of patients with cystic fibrosis 12.03.2002

Bacillus Calmette-Guerin vaccine Treatment of stage IIb through IV metastatic melanoma 09.08.2006

Bacitracin Altracin

Treatment of antibiotic-associated pseudomembranous enterocolitis caused by toxins A and B elaborated by Clostridium difficile. 13.03.1984

BaclofenTreatment of intractable spasticity due to multiple sclerosis or spinal cord injury. 16.12.1991

Baclofen Lioresal Intrathecal Treatment of spasticity associated with cerebral palsy. 26.09.1994

baclofen Treatment of dystonia 02.12.2003

Bardoxolone Treatment of pancreatic cancer 06.08.2008

beclomethasone Treatment of pediatriac patients with ulcerative colitis 04.03.2009

beclomethasone 17,21-dipropionate Bec Prevention of gastrointestinal graft-versus-host disease 28.08.2001

beclomethasone 17,21-diproprionate Treatment of pediatric patients with Crohn disease. 18.12.2007

Beclomethasone dipropionateFor oral administration in the treatment of intestinal graft-versus-host disease. 27.03.1998

belataceptProphylaxis of organ rejection in renal allograft recipients 20.02.2008

Benzophenone-3, octylmethoxycinnamate, avobenzone, titanium dioxide, zinc Total Block VL SPF 75

For the prevention of visible light induced skin photosensitivity as a result of porfimer sodium photodynamic therapy 13.08.2001

Benzydamine hydrochloride Tantum

Prophylactic treatment of oral mucositis resulting from radiation therapy for head and neck cancer. 18.05.1998

Benzylpenicillin, benzylpenicilloic, benzylpenilloic acid Pre-Pen/MDM

Assessing the risk of administrating penicillin when it is the preferred drug of choice in adult patients who have previously received penicillin and have a history of 29.09.1987

Beractant Survanta Intratracheal S

failure caused by meconium aspiration syndrome, persistent pulmonary hypertension of the newborn, or 20.12.1993

Beraprost

Treatment of pulmonary arterial hypertension associated with any New York Heart Association classification (Class I, II, III, or IV). 29.04.1999

Beta alethine Betathine Treatment of metastatic melanoma. 24.03.1997

Beta alethine Betathine Treatment of multiple myeloma. 24.03.1997

Betahistine dihydrochlorideTreatment of obesity associated with Prader Willi syndrome 08.11.2007

Bethanidine sulfatePrevention of recurrence of primary ventricular fibrillation. 24.11.1989

Bethanidine sulfate Treatment of primary ventricular fibrillation. 20.09.1988

Betulinic acid Topical treatment of metastatic melanoma 09.08.2007

Bevacizamub Avastin Treatment of malignant glioma 26.05.2006

Bevacizumab Avastin Therapeutic treatment of patients with ovarian cancer 09.02.2006

Bevacizumab Avastin Treatment of pancreatic cancer 20.10.2004

Bevacizumab Avastin Treatment of renal cell carcinoma 06.11.2003

bifidobacterium infantis 35624 Treatment of pediatric ulcerative colitis 24.03.2008

bifidobacterium longum infantis 35624 Treatment of pediatric Crohn's disease 16.01.2003

Bindarit Treatment of lupus nephritis. 03.02.1998Bioartificial liver system utilizing xenogenic hepatocytes in a hollow fiber bioreactor cartridge (BAL)

Treatment of patients with acute liver failure presenting with encephalopathy deteriorating beyond Parson's grade 2 11.02.2002

Bio-engineered oral mucosal tissue

phenotype to substitute for the normal corneal epithelium that is lost in patients due to total limbal stem cell deficiency

27.04.2006

Bis(4-fluorophenyl)phenylacetamide Treatment of sickle cell disease. 02.03.2000

Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19 Treatment of prolymphocytic leukemia 16.05.2008Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19 Treatment for hairy cell leukemia. 16.05.2008Bispecific molecule with two linked murine single-chain Fv regions Treatment of chronic lymphocytic leukemia 16.05.2008Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19 Treatment of acute lymphocytic leukemia 16.05.2008Bispecific molecule with two linked murine single-chain Fv regions directed against CD3 & CD19

Treatment of indolent B-cell lymphoma, excluding CLL and NHL with CNS involvement 06.02.2006

bivalirudin Angiomax

For use as an anticoagulant in patients with or at risk of heparin-induced thrombocytopenia/heparin-induced thrombocytopenia thrombosis syndrome 02.11.2005

Bleomycin Blenoxane Treatment of pancreatic cancer. 09.02.1999

BMY-45622 Treatment of ovarian cancer. 15.10.1990

bosentan Tracleer Treatment of idiopathic pulmonary fibrosis 30.09.2008

bosutinib Treatment of chronic myelogenous leukemia.

Botulinum toxin type A Dysport

Treatment of dynamic muscle contractures in pediatric cerebral palsy patients. 20.10.1999

Botulinum toxin type A Dysport Treatment of spasmodic torticollis (cervical dystonia). 12.08.1998

Botulinum toxin type A Dysport Treatment of essential blepharospasm. 23.03.1989

Botulinum toxin type A Botox

Treatment of dynamic muscle contracture in pediatric cerebral palsy patients. 06.12.1991

Botulinum toxin type ATreatment of synkinetic closure of the eyelid associated with VII cranial nerve aberrant regeneration. 15.09.1992

Botulinum toxin type F Treatment of spasmodic torticollis (cervical dystonia). 24.10.1991

Botulinum toxin type F Treatment of essential blepharospasm. 05.12.1991

Bovine colostrum Treatment of AIDS-related diarrhea. 19.11.1990Bovine immunoglobulin concentrate, Cryptosporidium parvum Sporidin-G

Treatment and symptomatic relief of Cryptosporidium parvum infection of the gastrointestinal tract in immunocompromised patients. 01.03.1994

Bovine whey protein concentrate Immuno-C

Treatment of cryptosporidiosis caused by the presence of Cryptosporidium parvum in the gastrointestinal tract of patients who are immunodeficient/immunocompromised or 30.09.1993

Branched chain amino acids Treatment of amyotrophic lateral sclerosis. 23.12.1988

Brimonidine Alphagan Treatment of anterior ischemic optic neuropathy. 07.02.2000

Brivaracetam Treatment of symtomatic myoclonus 05.10.2005

Brivudin Adjunct treatment of pancreatic cancer 15.11.2007

Bromhexine Bisolvon

Treatment of mild to moderate keratoconjunctivitis sicca in patients with Sjogren's syndrome. 15.05.1989

Broxuridine Broxine/Neomark

Radiation sensitizer in the treatment of primary brain tumors. 18.09.1995

bryostatin-1For use in combination with paclitaxel in the treatment of esophageal cancer 03.12.2001

Buffered Ursodeoxycholic Acid Ursocarb Treatment of pruritus in patients with Alagille Syndrome 03.09.2004

bupivacaine Transdur

Relief of persistent pain asociated with postherpetic neuralgia 18.06.2008

Busulfan Spartaject

For use as preparative therapy for malignancies treated with bone marrow transplantation. 21.04.1994

Busulfan Spartajet-Busulfan Intrathecal therapy for neoplastic meningitis 05.03.2001

busulfan Partaject

Preparative therapy for pediatric patients undergoing bone marrow transplantation 25.11.2002

Busulfan Spartaject Treatment of primary brain malignancies. 07.07.1997

Buthionine sulfoxamineFor use in children as a modulator of chemotherapy for the treatment of pediatric patients with neuroblastoma 05.10.2005

Buthionine sulfoxamine

Use as a modulator of chemotherapy for the treatment of pediatric patients with primary malignant brain tumors 05.10.2005

Butyrylcholinesterase Treatment of post-surgical apnea. 30.09.1992

ButyrylcholinesteraseFor the reduction and clearance of toxic blood levels of cocaine encountered during a drug overdose. 25.03.1992

BW 12C Treatment of sickle cell disease. 23.10.1987

C1 esterase inhibitor (human)Treatment and prevention of angioedema caused by C1-esterase inhibitor deficiency. 21.08.1996

C1-esterase-inhibitor, human, pasteurized Berinert P

Prevention and/or treatment of acute attacks of hereditary angioedema. 16.10.1992

C1-inhibitor C1-inhibitor (human) va

Prevention of acute attacks of angioedema, including short-term prophylaxis for patients requiring dental or other surgical procedures. 30.08.1990

C1-inhibitor C1-inhibitor (human) vaTreatment of acute attacks of angioedema. 30.08.1990

cAC10-vcMMAE (4) Treatment of Hodgkin's lymphoma. 30.01.2007

Calcitonin salmon nasal spray Miacalcin Nasal Spray

Treatment of symptomatic Paget's disease (osteitis deformans). 29.10.1990

Calcium acetateTreatment of hyperphosphatemia in end stage renal disease. 27.06.1989

Calcium carbonate R & D calcium carbona

Treatment of hyperphosphatemia in patients with end stage renal disease. 06.06.1990

Calcium gluconate Calgonate

For use as a wash for hydrofluoric acid spills on human skin. 20.11.1997

Calcium gluconate gel H-F Gel

For use in the emergency topical treatment of hydrogen fluoride (hydrofluoric acid) burns. 21.05.1991

Calcium gluconate gel 2.5%Emergency topical treatment of hydrogen fluoride (hydrofluoric acid) burns. 10.09.1990

Calfactant Infasurf Acute respiratory distress syndrome (ARDS) 05.09.2000

canakinumab Treatment of systemic onset juvenile idiopathic arthritis 30.09.2008

Capsaicin Treatment of postherpetic neuralgia. 03.08.2005

Capsaicin

Treatment of intermetatarsal neuroma (Morton's Neuroma) that does not respond to conservative treatment and requires either neurectomy or neurolysis 29.09.2006

capsaicin Treatment of erythromelalgia 23.10.2002

Capsaicin Treatment of painful HIV-associated neuropathy 02.05.2003

Carbamylglutamic acid Treatment of N-acetylglutamate synthetase deficiency. 20.01.1998

carbon monoxide Covox

For use in the reduction of the incidence and severity of delayed graft function in patients undergoing solid organ transplanation. 24.06.2008

Carbovir

Treatment of persons with AIDS and in patients with symptomatic HIV infection and a CD4 count less than 200/mm3. 13.12.1989

cardiotrophin-1To protect the liver from ischemia-reperfusion injury inherent to the procedure of transplantation. 24.06.2008

carfilzomib Treatment of multiple myeloma 18.01.2008

Carmustine Treatment of intracranial malignancies. 03.07.2000

Cascara sagrada fluid extractTreatment of oral drug overdosage to speed lower bowel evacuation. 21.03.1989

Catumaxomab Removab Treatment of ovarian cancer 09.06.2006

CD4 human truncated 369 AA polypeptide Soluble T4 Treatment of acquired immunodeficiency syndrome. 21.11.1989

CD5-T lymphocyte immunotoxin Xomazyme-H65

Treatment of graft versus host disease and/or rejection in patients who have received bone marrow transplants. 27.08.1987

CDP571 Treatment of Crohn's disease. 11.12.1997

CDX-110Treatment of EGFRvIII-expressing glioblastoma multiforme 19.11.2007

Ceftriaxone sodium Rocephin Treatment of amyotrophic lateral sclerosis 28.03.2006Cells produced using the AastromReplicelle System and SC-I Therapy Kit

For use in patients receiving high dose chemotherapy who are unable to generate an acceptable dose of peripheral blood stem cells and who have a sufficient bone marrow aspirate without morphological evidence 10.07.2002

cenersen Aezea Treatment of stage IIB through IV melanoma 18.06.2008

cenersen Treatment of acute myeloid leukemia 08.05.2006

cenersen Aezea Treatment of chronic lymphocytic leukemia 27.02.2008

Centruroides immune F(ab)2 Alacramyn

Treatment of scorpion envenomations requiring medical attention. 12.06.2000

cethromycinProphylactic treatment of patients exposed to inhalation anthrax. 28.02.2007

Cetiedil citrate injection Treatment of sickle cell disease crisis. 22.12.1988

cetuximab Erbitux Treatment of pancreatic cancer 15.06.2007

Chenodeoxycholic acid Chenofalk Treatment of cerebrotendinous xanthomatosis 29.01.2004

chenodeoxycholic acid Treatment of cerebrotendinous xanthomatosis 12.02.2007

Chimeric (human-murine) G250 IgG monoclonal antibody Treatment of renal cell carcinoma. 24.07.2000

chimeric (murine-human) IgG1 mAb against IL-6 Treatment of multiple myeloma 11.10.2005Chimeric (murine-human) IgG1k monoclonal antibody against interleukin-6 Treatment of Castleman's disease 26.05.2006

Chimeric monoclonal antibodies For treatment of shiga-toxin producing bacterial infection. 04.10.2005

Chimeric monoclonal antibody to mesothelin Treatment of pancreatic cancer 31.10.2006

Chimeric M-T412 (human-murine) IgG monoclonal anti-CD4 Treatment of multiple sclerosis. 05.06.1991chimeric murine/human IgG1 monoclonal antibody to human interleukin-3 receptor alpha chain Treatment of acute myeloid leukemia 03.04.2009

Chimeric, humanized monoclonal antibody to staphylococcus

Prophylaxis of Staphylococcus epidermidis sepsis in low birth weight (1500 grams or less) infants. 03.08.2000

Chlorhexidine gluconate mouthrinse Peridex

For use in the amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy. 18.08.1986

chlorotoxin Treatment of stage IIb, IIc, III & IV melanoma 02.12.2008

Chlorotoxin Treatment of malignant glioma 18.12.2007

cholest-4-en-3-one, oxime Treatment of spinal muscular atrophy. 17.02.2009cholic acid (3 alpha, 7 alpha, 12 alpha trihydroxy 5-beta cholanolic Falkochol

Treatment of inborn errors of cholesterol and bile acid synthesis and metabolism 18.07.2003

Choline chloride IntraChol

Prevention and/or treatment of choline deficiency in patients on long-term parenteral nutrition 20.07.2006

Choline chloride Intrachol

Treatment of choline deficiency, specifically the choline deficiency, hepatic steatosis, and cholestasis, associated with long-term parenteral nutrition. 10.02.1994

Chondrocyte-alginate gel suspension

For use in correcting vesicoureteral reflux in the pediatric population. 01.12.1997

Chondroitinase Treatment of patients undergoing vitrectomy. 09.02.1995

cicletanine hydrochloride Treatment for pulmonary arterial hypertension. 24.06.2008

cilengitide Treatment of malignant glioma 27.05.2005

Ciliary neurotrophic factor Treatment of amyotrophic lateral sclerosis. 30.01.1992Ciliary neurotrophic factor, recombinant human

Treatment of motor neuron disease (including amyotrophic lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy, and primary lateral 08.05.1992

Ciliary neurotrophic factor, recombinant human Treatment of spinal muscular atrophies. 02.04.1992

Cisplatin in liposomal formulation SLIT Cisplatin for inhalaTreatment of osteogenic sarcoma metastatic to the lung 20.03.2007

Cisplatin/epinephrine IntraDose Treatment of metastatic malignant melanoma. 07.09.2000

Cisplatin/epinephrine IntraDose

Treatment of squamous cell carcinoma of the head and neck. 03.04.2000

Civamide Zucapsaicin

Treatment of postherpetic neuralgia of the trigeminal nerve 09.12.2002

Cladribine Leustatin Treatment of acute myeloid leukemia. 20.07.1990

Cladribine Leustatin Injection Treatment of chronic lymphocytic leukemia. 31.12.1990

Cladribine Mylinax

Treatment of the chronic progressive form of multiple sclerosis. 19.04.1994

Cladribine Leustatin Injection Treatment of non-Hodgkin's lymphoma. 19.04.1993

Clazosentan Erajet

Treatment of cerebral vasospasm following subarachnoid hemorrhage 16.02.2006

Clindamycin Cleocin

Prevention of Pneumocystis carinii pneumonia in AIDS patients. 28.10.1988

Clindamycin Cleocin

Treatment of Pneumocystis carinii pneumonia associated with AIDS patients. 28.10.1988

Clindamycin hydrochloride Treatment of sarcoidosis 09.08.2006

clobazam Treatment of Lennox-Gastaut Syndrome. 18.12.2007

clofarabine Clofarex Treatment of acute myelogenous leukemia 14.03.2002

Clonazepam Klonopin Treatment of hyperekplexia (startle disease). 04.08.1994

Clonazepam Intranasal Spray Treatment of recurrent acute repetitive seizures 19.12.2007

Clostridial collagenaseTreatment of advanced (involutional or residual stage) Dupuytren's disease. 23.05.1996

Clotrimazole Topical treatment of children and adults with pouchitis 14.06.2005

Clotrimazole Treatment of Huntington's disease 13.03.2006

Clotrimazole Treatment of sickle cell disease. 24.04.1995

c-myb antisense oligodeoxynucleotide Treatment of chronic myelogenous leukemia 22.02.2005

Coagulation factor VIIa (recombinant) NovoSeven

Prevention of bleeding episodes in Glanzmann's thrombasthenia 18.06.2004

Coagulation factor VIIa (Recombinant) NovoSeven

Treatment of bleeding episodes in Glanzmann's thrombasthenia 18.06.2004

Coagulation Factor VIIa (Recombinant) NovoSeven

Treatment of bleeding in patients experiencing intracranial hemorrhage. 03.10.2006

cobiprostone Treatment of cystic fibrosis 14.11.2002

coccidioidin SD Skin Test Antigen For the diagnosis of Coccidioidomycosis. 19.12.2007

Coenzyme Q10 Treatment of Huntington's disease 05.03.2001

Colchicine Treatment of familial Mediterranean fever 25.09.2007

Colchicine Treatment of Behcet's Syndrome 25.09.2007

ColchicineFor arresting the progression of neurologic disability caused by chronic progressive multiple sclerosis. 09.12.1985

Collagenase (lyophilized) for injection Plaquase Treatment of Peyronie's disease. 12.03.1996

Combretastatin A4 phosphate Treatment of ovarian cancer 08.05.2006

Combretastatin A4 Phosphate

Treatment of anaplastic thyroid cancer, medullary thyroid cancer, and stage IV papillary or follicular thyroid cancer 23.07.2003

conjugate of human transferrin and a mutant diphtheria toxin (CRM 107) TransMID

Treatment of malignant tumors of the central nervous system 03.12.2001

conjugated bile acids COBARTin

Treatment of steatorrhea in patients with short bowel syndrome 18.07.2003

Contulakin-GIntrathecal treatment of neuropathic pain associated with spinal cord injury 07.07.2005

Cordycepin Treatment of TdT-positive acute lymphocytic leukemia 05.07.2007

Corticotropin-releasing factor, human Xerecept Treatment of peritumoral brain edema. 06.04.1998

Coumarin Onkolox Treatment of renal cell carcinoma. 22.12.1994

Coxsackievirus A21 Cavatak

Treatment of stage II (T4), stage III, and stage IV melanoma 15.12.2005

Creatine Creapure Treatment of Huntington's disease 11.10.2005

creatine Creapure Treatment of amyotrophic lateral sclerosis 12.02.2002

Cry5BTreatment of soil transmitted helminth infection strongyloidiasis 05.09.2008

Cryptosporidium hyperimmune bovine colostrum IgG concentrate

Treatment of diarrhea in AIDS patients caused by infection with Cryptosporidium parvum. 30.12.1991

cultured, partially T-Cell depleted, allogenic thymic tissue for transplantation

As a therapy for primary immune deficiency resulting from athymia associated with complete DiGeorge Syndrome 15.08.2003

CY-1503 Cylexin

Treatment of neonates and infants undergoing cardiopulmonary bypass during surgical repair of congenital heart lesions. 18.07.1997

CY-1503 Cylexin

Treatment of post-ischemic pulmonary reperfusion edema following surgical treatment for chronic thromboembolic pulmonary hypertension. 22.12.1993

CY-1899Treatment of chronic active hepatitis B infection in HLA-A2 positive patients. 16.03.1994

Cyclo {{(E,Z)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)nona-6,8-dienoyl}-L-

Treatment and chronic control of non-infectious posterior, intermediate and pan-uveitis 20.12.2006

Cyclosporin A Mitogard

Treatment of amyotrophic lateral sclerosis and its variants 29.10.2004

cyclosporine Prophylaxis of graft-versus-host disease 17.02.2009

cyclosporine Treatment of graft-versus-host disease 17.02.2009

CyclosporineProphylaxis of organ rejection in patients receiving allogeneic lung transplant Kristin Miller, CSO, HFD-590. 25.11.2003

Cyclosporine Pluminiq

Treatment of acute rejection in patients requiring allogenic lung transplants 25.11.2003

Cyclosporine 2% ophthalmic ointment

Treatment of patients at high risk of graft rejection following penetrating keratoplasty. 01.08.1991

Cyclosporine 2% ophthalmic ointment

For use in corneal melting syndromes of known or presumed immunologic etiopathogenesis, including Mooren's ulcer. 01.08.1991

Cyclosporine A Treatment of vernal keratoconjunctivitis 04.05.2007

cyclosporine A Prevention of corneal graft rejection 30.09.2008

cyclosporine A NOVA22007 Treatment of herpes simplex virus stromal keratitis 09.04.2008

Cyclosporine A implantFor the prevention of acute rejection in cornea transplant patients 08.01.2007

Cyclosporine in combination with omega-3 polyunsaturated fatty acids Prevention of solid organ graft rejection. 06.12.2000

Cyclosporine ophthalmic Optimmune

Treatment of severe keratoconjunctivitis sicca associated with Sjogren's syndrome. 09.11.1988

Cyproterone acetate Androcur Treatment of severe hirsutism. 26.10.1984

Cys-His-Ala-Val-Cys

For use in conjunction with melphalen for the treatment of malignant melanoma, AJCC stages IIB, IIC, III and IV 14.02.2008

cysteamineTreatment of neuronal ceroid lipofuscinoses (Batten disease) 06.08.2008

cysteamine Treatment of Huntington's disease 09.05.2008

Cysteamine Treatment of nephropathic cystinosis. 01.05.1986

Cysteamine hydrochlorideTreatment of corneal cystine crystal accumulation in cystinosis patients. 19.08.1997

Cystic fibrosis gene therapy Treatment of cystic fibrosis. 30.06.1992

Cystic fibrosis Tr gene therapy (recombinant adenovirus) AdGVCFTR.10 Treatment of cystic fibrosis. 09.03.1995

Cystic fibrosis transmembrane conductance regulator

For cystic fibrosis transmembrane conductance regulator protein replacement therapy in cystic fibrosis patients. 14.01.1992

Cystic fibrosis transmembrane conductance regulator gene Treatment of cystic fibrosis. 08.01.1993

cytarabine liposome DepoCyt Treatment of gliomas 30.01.2007

Cytarabine:daunorubicin liposome injection Treatment of acute myeloid leukemia 22.08.2008Cytomegalovirus DNA Vaccine w/Copolymer/Benzalkonium Chloride

For use in prevention of clinically significant CMV viremia, CMV disease and associated complications in at-risk hematopoietic cell transplant and solid organ transplant populations 23.09.2006

Cytomegalovirus DNA vaccine with plasmids expressing pp65 and gB genes

Prevention of clinically significant cytomegalovirus (CMV) viremia, CMV disease and asociated complications in at-risk hematopoietic cell transplant and solid transplant populations 03.06.2005

Cytomegalovirus immune globulin intravenous (human)

For use in conjunction with ganciclovir sodium for the treatment of cytomegalovirus pneumonia in bone marrow transplant patients. 28.01.1991

Dantrolene sodium Dantrium Treatment of the neuroleptic malignant syndrome. 14.12.1987

Dapsone

Prophylaxis of toxoplasmosis in severely immunocompromised patients with CD4 counts below 100. 07.11.1994

Dapsone USP Dapsone

For the combination treatment of Pneumocystis carinii pneumonia in conjunction with trimethoprim. 08.01.1992

Dapsone USP Dapsone Prophylaxis for Pneumocystis carinii pneumonia. 24.12.1991

Daunorubicin liposomal Treatment of acute myeloid leukemia 05.09.2008

DEAE-rebeccamycin Treatment of bile duct tumors 01.03.2004

debrase Debridase

Debridement of acute, deep dermal burns in hospitalized patients 20.08.2003

Decitabine Dacogen Treatment of acute myeloid leukemia 04.08.2006

decitabine Treatment of sickle cell anemia 09.09.2002

Decitabine Treatment of chronic myelogenous leukemia. 08.03.1999

deferiprone Treatment of Friedreich's ataxia. 31.07.2008

deferiprone Ferriprox

Treatment of iron overload in patients with hematologic disorders requiring chronic transfusion therapy 12.12.2001

deferoxamine-starch conjugate Treatment of acute iron poisoning. 28.01.2005

defibrotide For the prevention of hepatic veno-occlusive disease. 08.01.2007

Defibrotide For the treatment of hepatic veno-occlusive disease 21.05.2003

Defibrotide Treatment of thrombotic thrombocytopenic purpura. 05.07.1985

Dehydroepiandrosterone

Treatment of systemic lupus erythematosus (SLE) and the reduction in the use of steroids in steroid-dependent SLE patients. 13.07.1994

Dehydroepiandrosterone (DHEA) Fidelin

Replacement therapy in individuals with adrenal insufficiency 19.08.2003

Dehydroepiandrosterone sulfate sodium Treatment of serious burns requiring hospitalization. 29.01.1997

Dehydroepiandrosterone sulfate sodium

To accelerate the re-epithelialization of donor sites in those hospitalized burn patients who must undergo autologous skin grafting. 28.01.1997

Deslorelin Somagard 05.11.1987

Desmoglein 3 synthetic peptide (PI-0824) Treatment of pemphigus vulgaris 26.10.2004

Dexamethasone Posurdex

For use in posterior segment drug delivery system in the treatment of idiopathic intermediate uveitis. 11.09.1998

dexamethasone phosphate Treatment of corneal graft rejection. 02.12.2008

dexanabinol

For the attenuation or amelioration of the long-term neurological sequelae associated with moderate and severe traumatic brain injury 11.08.2004

dextran 1 Treatment of cystic fibrosis 21.03.2003

Dextran 70 Dehydrex

Treatment of recurrent corneal erosion unresponsive to conventional therapy. 05.03.1990

Dextran and deferoxamine Bio-Rescue Treatment of acute iron poisoning. 08.03.1991

Dextran sulfate (inhaled, aerosolized) Uendex For use as an adjunct to the treatment of cystic fibrosis. 05.10.1990

Dextran sulfate sodium Treatment of aquired immunodeficiency syndrome. 19.11.1987

DHA-paclitaxel Taxoprexin Treatment of pancreatic cancer 25.09.2001

DHA-paclitaxel Taxoprexin

Treatment of adenocarcinoma of the stomach or lower esophagus 01.05.2003

DHA-paclitaxel Taxoprexin Treatment of metastatic malignant melanoma 10.10.2002

Dianeal peritoneal dialysis solution with 1.1% amino acids Nutrineal (Peritoneal Di

For use as a nutritional supplement for the treatment of malnourishment in patients undergoing continuous ambulatory peritoneal dialysis. 11.06.1992

DiaziquoneTreatment of primary brain malignancies (grade III and IV astrocytomas). 10.11.1983

Dideoxyinosine Treatment of acquired immunodeficiency syndrome. 22.06.1988

Diethyldithiocarbamate Imuthiol Treatment of AIDS. 03.04.1986diethylenetriaminepentaacetate (DPTA)

internal contamination with plutonium, americium or curium to increase the rates of elimination. 14.04.2004

Diethylnorspermine (DENSPM) Treatment for hepatocellular carcinoma 25.05.2004

diferuloylmethane Treatment of cystic fibrosis 13.06.2003

difluprednate Durezol

Treatment of endogenous and traumatic anterior uveitis and panuveitis. 30.09.2008

Digitoxin Treatment of cystic fibrosis 27.05.2005

digitoxin Treatment of soft tissue sarcomas 18.10.2001

digitoxin Treatment of ovarian cancer 02.11.2001

Digoxin immune fab(ovine) Digidote

Treatment of life-threatening acute cardiac glycoside intoxication manifested by conduction disorders, ectopic ventricular activity and (in some cases) hyperkalemia. 11.03.1985

dihydroartemisinin and piperaquine Eurartesim

Treatment of uncomplicated malaria caused by "Plasmodium falciparum," Plasmodium vivax," Plasmodium malariae," or "Plasmodium ovale." 08.01.2007

Dihydrotestosterone Androgel -DHT

Treatment of weight loss in AIDS patients with HIV-associated wasting. 05.02.1996

dimethyl sulfoxideFor use in combination with antimicrobial drugs for the treatment of drug resistant tuberculosis 09.05.2008

Dimethyl sulfoxide

Treatment of increased intracranial pressure in patients with severe, closed-head injury, also known as traumatic brain coma, for whom no other effective treatment is available. 22.11.1994

Dimethyl sulfoxide Treatment of cutaneous manifestations of scleroderma. 06.06.1986

DimethylsulfoxideTreatment of palmar-plantar erythrodysethesia syndrome. 06.04.1998

DimethylsulfoxideTopical treatment for the prevention of soft tissue injury following extravastion of cytotoxic drugs. 15.04.1997

Dipalmitoylphosphatidylcholine /phosphatidylglycerol ALEC

Prevention and treatment of neonatal respiratory distress syndrome. 28.07.1988

diphenylcyclopenoneTreatment of chronic severe forms of alopecia areata (Alopecia Totalis [AT]/Alopecia Universalis [AU]) 13.06.2003

Disaccharide tripeptide glycerol dipalmitoyl Immther

Treatment of pulmonary and hepatic metastases in patients with colorectal adenocarcinoma. 01.03.1990

Disodium clodronate Treatment of hypercalcemia of malignancy. 16.06.1993

Disodium clodronate tetrahydrate Bonefos

Treatment of increased bone resorption due to malignancy. 05.03.1990

Disodium silibinin dihemisuccinate Legalon

Treatment of hepatic intoxication by Amanita phalloides (mushroom poisoning). 10.07.1986

D-mannitol and L-proline Prodarsan(r) Treatment of Cockayne syndrome 20.04.2009

DMP 777Therapeutic management of patients with lung disease attributable to cystic fibrosis. 04.06.1996

DNA plasmid vector expressing human IL-12 gene Treatment of ovarian cancer. 04.04.2005DNA-lipid complex (DMRIE/DOPE)/plasmid vector (VCL-1102, Vical) expressing Leuvectin Treatment of renal cell carcinoma. 28.04.2000

DNP-Modified autologous tumor vaccine O-Vax Adjuvant therapy for the treatment of ovarian cancer 21.09.2000

docosahexanoic acid-paclitaxel Taxoprexin Treatment of hormone-refractory prostate cancer. 05.03.2001

Doripenem

Treatment of bronchopulmonary infection in patients with cystic fibrosis who are colonized with Pseudomonas aeruginosa or Burkholderia cepacia. 16.07.2004

Dovitinib Treatment of multiple myeloma 03.10.2006Doxorubicin HCl with pluronic L-61 and pluronic F-127 Treatment of esophageal carcinoma 07.10.2005

doxorubicin PIHCA nanoparticles Doxorubicin TransdrugTreatment of hepatocellular carcinoma 14.03.2005doxorubicin with pluronics F-127 and L-61 Treatment of gastric cancer 20.02.2008

D-peptide of the sequence AKRHHGYKRKFH - NH2 PulmaDex Treatment of cystic fibrosis 23.10.2002

D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-Nh2 (disulfide bridge: 2-6) acetate Treatment of melanoma, stages IIb through IV 19.03.2009

droxidopa

Treatment of neurogenic symptomatic orthostatic hypotension in patients with primary autonomic failure, dopamine-beta-hydroxylase deficiency, and nondiabetic autonomic neuropathy. 17.01.2007

Duramycin Treatment of cystic fibrosis. 11.12.1997

DynamineTreatment of hereditary motor and sensory neuropathy type I (Charcot-Marie-Tooth disease). 16.10.1991

Dynamine Treatment of Lambert Eaton myasthenic syndrome. 05.02.1990

ecallantide Kalbitor Treatment of angioedema 04.02.2003

eculizumab Soliris(r) Treatment of atypical hemolytic uremic syndrome 29.04.2009

eculizumabTreatment of idiopathic membranous glomerular nephropathy 05.03.2001

Eculizumab Treatment of dermatomyositis 21.09.2000

Edotreotide OctreoTher

Treatment of somatostatin receptor-positive neuroendocrine gastroenteropancreatic tumors 28.07.2005

efaproxiral

Adjunct to whole brain radiation therapy for the treatment of brain metastases in patients with breast cancer 28.07.2004

Eflornithine Treatment of anaplastic glioma 29.09.2006

Eflornithine HCl Ornidyl

Treatment of Pneumocystis carinii pneumonia in AIDS patients. 18.04.1986

Elcatonin Intrathecal treatment of intractable pain. 25.09.1995

Enadoline hydrochloride Treatment of severe head injury. 28.01.1997

Encapsulated porcine islet preparation BetaRx

Treatment of type I diabetic patients who are already on immunosuppression. 05.07.1995

eniluracil Treatment of hepatocellular carcinoma 15.12.2005

EnisoprostFor use in organ transplant patients to diminish the nephrotoxicity induced by cyclosporine. 20.10.1989

EnisoprostFor use with cyclosporine in organ transplant recipients to reduce acute transplant rejection. 20.10.1989

Enteric-coated cysteamine Treatment of cystinosis 24.10.2006

enzastaurin Treatment of diffuse large B-cell lymphoma 04.03.2009

Enzastaurin Treatment of glioblastoma multiforme 19.09.2005

Epidermal growth factor (human)

For acceleration of corneal epithelial regeneration and the healing of stromal tissue in the condition of non-healing corneal defects. 05.10.1987

Epidermal growth factor (human)For promotion of cutaneous wound healing in extreme burn treatment protocols. 06.03.1985

Epoetin alfa Treatment of myelodysplastic syndrome. 20.12.1993

Epoetin alpha Procrit

Treatment of anemia associated with end stage renal disease. 27.08.1987

Epoetin alpha Procrit Treatment of anemia of prematurity in preterm infants. 21.07.1988

Epoetin alpha Procrit

Treatment of HIV associated anemia related to HIV infection or HIV treatment. 07.03.1989

Epoetin beta Marogen

Treatment of anemia associated with end stage renal disease. 22.10.1987

Epoprostenol Flolan

Replacement of heparin in patients requiring hemodialysis and who are at increased risk of hemorrhage. 29.03.1984

Epoprostenol Cycloprostin

Replacement of heparin in patients requiring hemodialysis and who are at increased risk of hemorrhage. 29.10.1984

epratuzumab Treatment of acute lymphoblastic leukemia 30.09.2008

epratuzumab LymphoCIDE Treatment of non-Hodgkin's lymphoma. 13.07.1998

Eprodisate Fibrillex Treatment of secondary amyloidosis 06.04.1999

Epstein Barr Virus specific cytotoxic T lymphocytes

Prevention and treatment of EBV-post transplant lymphoproliferative disease after hematopoietic stem cell transplant or solid organ transplant. 27.12.2006

Erlotinib Hydrochloride Tarceva Treatment of malignant gliomas 18.07.2003

Erwinia L-asparaginase Erwinase Treatment of acute lymphocytic leukemia. 30.07.1986

Erwinia L-asparaginase

For use as an alternative to E. coli asparaginase in those situations where repeat courses of asparaginase therapy for acute lymphoblastic leukemia are required or where allergic reactions force the discontinuance of 25.01.1985

Erythropoietin (human, recombinant)

Treatment of anemia associated with end stage renal disease. 19.11.1987

Erythropoietin (recombinant human)

Treatment of anemia associated with end stage renal disease. 19.08.1987

Estradiol Gel EstroGel (r)

Estrogen replacement therapy in females with Turner syndrome 31.10.2006

Etanercept Enbrel Treatment of Wegener's granulomatosis. 06.04.1999

Ethanol gel Treatment of congenital lymphatic malformations 13.03.2006

Ethanol gel Treatment of congenital venous malformations 29.03.2006

Ethinyl Estradiol, USP Treatment of Turner's syndrome. 22.06.1988

EthiofosUse as a chemoprotective agent for cisplatin and cyclophosphamide in the treatment of ovarian cancer. 01.08.1989

Ethyl eicosapentaenoate Treatment of Huntington's disease. 06.04.2000

Etidronate disodium Didronel IV infusion

Prevention of degenerative metabolic bone disease occurring in patients who require long term (6 months or greater) total parenteral nutrition. 02.05.1991

Etidronate disodium Didronel IV Infusion

Treatment of degenerative metabolic bone disease occurring in patients who require long term (6 months or greater) total parenteral nutrition. 02.05.1991

Etiocholanedione Treatment of Prader-Willi syndrome. 07.05.1996

Etiocholanedione Treatment of aplastic anemia. 03.11.1995

everolimusTreatment of gastroenteropancreatic neuroendocrine tumors 14.02.2008

Ex vivo cultured adult human mesenchymal stem cells Prochymal Treatment of acute graft versus host disease 14.12.2005

Exisulind

For the suppression and control of colonic adenomatous polyps in the inherited disease adenomatous polyposis coli. 14.02.1994

Factor XIII [A2] homodimer, recombinant DNA origin Treatment of congenital FXIII deficiency 21.05.2003

Factor XIII [A2} homodimer, recombinant DNA origin

For the prophylaxis of bleeding associated with congential FXIII deficiency 06.11.2003

factor XIII concentrate (human), pasteurized Fibrogammin P Treatment of congenital factor XIII deficiency. 16.01.1985

Factor XIII, recombinant Treatment of congenital factor XIII deficiency. 22.04.1993

Fampridine Neurelan Relief of symptoms of multiple sclerosis. 02.06.1987

Fampridine Neurelan Treatment of chronic, incomplete spinal cord injury. 02.06.1997

Fenobam hydrochloride Treatment of fragile X syndrome 20.11.2006

fenretinide Treatment of Ewing's sarcoma family of tumors. 01.02.2007

Fenretinide Treatment of neuroblastoma 05.10.2005ferric hexacyanoferrate (II) "Prussian Blue"

contamination with radioactive or non-radioactive cesium or thallium 26.06.2003

FIAU Adjunctive treatment of chronic active hepatitis B. 24.07.1992

Fibrinogen (human)For the control of bleeding and prophylactic treatment of patients deficient in fibrinogen. 23.08.1995

Fibronectin (human plasma derived)

Treatment of non-healing corneal ulcers or epithelial defects which have been unresponsive to conventional therapy and the underlying cause has been eliminated. 05.09.1988

Fibronectin (plasma derived)

Treatment of non-healing corneal ulcers or epithelial defects which are unresponsive to conventional therapy and for which any infectious cause of the defect has been eliminated. 05.12.1988

Filgrastim Neupogen Treatment of myelodysplastic syndrome. 30.08.1990

Filgrastim Neupogen

Treatment of patients with AIDS who, in addition, are afflicted with cytomegalovirus retinitis and are being treated with ganciclovir. 03.09.1991

Floxuridine, FUDR Intraperitoneal treatment of gastric cancer. 22.12.2004

Fludarabine phosphate Fludara

Treatment and management of patients with non-Hodgkins lymphoma. 18.04.1989

Flumecinol Zixoryn

Treatment of hyperbilirubinemia in newborn infants unresponsive to phototherapy. 15.01.1985

Flunarizine Sibelium Treatment of alternating hemiplegia. 06.01.1986

Fluorouracil Adrucil

For use in combination with leucovorin for therapy of metastatic adenocarcinoma of the colon and rectum. 06.02.1989

Fluorouracil

For use in combination with interferon alpha-2a, recombinant, for the treatment of esophageal carcinoma. 27.10.1989

Fluorouracil

For use in combination with interferon alpha-2a, recombinant, for the treatment of advanced colorectal carcinoma. 18.04.1990

Fluorouracil Treatment of glioblastoma multiforme. 29.06.2000

Fluoxetine Prozac Treatment of autism. 30.04.1999

Fluoxetine Prozac

Treatment of body dysmorphic disorder in children and adolescents 14.04.2004

fosfomycin/tobramycinTreatment of pulmonary infections associated with cystic fibrosis. 28.11.2008

Fructose-1,6-diphosphate Cordox

Treatment of painful vaso-occlusive episodes associated with sickle cell disease. 29.05.1998

Full Phosphorothioate Antisense Oligonucleotide against EWS-Fli-1 nanoparticles Treatment of Ewing's sarcoma 22.09.2008

Fully Human Anti-MCP-1/CCL2 Monoclonal Antibody Treatment of idiopathic pulmonary fibrosis. 08.11.2007Fusion protein consisting of human immunoglobim G1 constant region Fc region fused to

Treatment of X-linked hypohidrotic ectodermal dysplasia 11.01.2006

G17DT Immunogen Treatment of gastric cancer 18.07.2002

G17DT Immunogen Treatment of adenocarcinoma of the pancreas 10.07.2002

Gabapentin Neurontin Treatment of amyotrophic lateral sclerosis. 05.07.1995

Gamma hydroxybutyrate

Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations and automatic behavior. 03.12.1987

Gamma-hydroxybutyric acid

Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations, and automatic behavior. 22.01.1985

Gammalinolenic acid Treatment of juvenile rheumatoid arthritis. 27.07.1994

Ganaxolone Treatment of infantile spasms. 25.05.1994

Ganciclovir Virgan

Treatment of acute herpetic keratitis (dendritic and geographic ulcers) 22.03.2007

GancyclovirTreatment of severe human cytomegalovirus infections in specific immunosuppressed patient populations. 07.06.1985

Gangliosides as sodium salts Cronassial Treatment of retinitis pigmentosa. 17.11.1988

Gavilimomab Acute graft-versus-host disease (aGVHD) 20.11.2000

gene encoding chimeric CD40 ligand Treatment of chronic lymphocytic leukemia 04.02.2009Gene plasmid hVEGF165 driven by human cytomegalovirus, and [2,3-bis(oleoyl)propyl]trimethyl Trinam

Prevention of complications due to neointimal hyperplasia disease in certain vascular anastomoses. 24.10.2000

genetically engineered herpes simplex virus (G207) Tretament of malignant glioma 29.04.2002

Geneticin Treatment of amoebiasis. 06.06.2005

Gentamicin impregnated PMMA beads on surgical wire Septopal

Treatment of chronic osteomyelitis of post-traumatic, postoperative, or hematogenous origin. 31.01.1991

Gentamicin liposome injection Maitec

Treatment of disseminated Mycobacterium avium-intracellulare infection. 10.07.1990

glatiramer acetate Copaxone Treatment of amyothrophic lateral sclerosis (ALS). 14.11.2007

Glatiramer acetate for injection Copaxone Treatment of primary-progressive multiple sclerosis 05.06.2001

glucarpidase Voraxaze Treatment of patients at risk of methotrexate toxicity 19.08.2003

glufosfamide For treatment of pancreatic cancer. 18.09.2006

Glycafilin

Prevention of delayed graft function after solid organ transplantation

22.08.2008

Glyceol

To decrease intracranial hypertension and/or alleviate cerebral edema in patients who may benefit from osmotherapy. 22.02.1990

Glyceryl tri (4-phenylbutyrate) Treatment of spinal muscular atrophy 24.05.2005

glyceryl tri (4-phenylbutyrate)Maintenance treatment of patients with deficiencies in enzymes of the urea cycle 27.04.2009

Glyceryl trioleate and glyceryl trierucate Treatment of adrenoleukodystrophy. 14.02.1995

Glycopyrrolate Treatment of pathologic (chronic moderate to severe) drooling in pediatric patients 09.06.2006

GMI-1070Treatment of vaso-occlusive crisis in patients with sickle cell disease. 17.02.2009

GNE Lipoplex Treatment of hereditary inclusion body myopathy-2 13.11.2008

Golimumab Treatment of chronic sarcoidosis 02.11.2004

Gossypol Treatment of cancer of the adrenal cortex. 22.10.1990

Gp100 adenoviral gene therapy Treatment of metastatic melanoma. 25.03.1997

granulocyte macrophage colony stimuling factor Treatment of cystic fibrosis 27.08.2008

Granulocyte macrophage-colony stimulating factor Leucomax

Treatment of severe thermal injuries in patients with greater than 40% full or partial thickness burns. 06.06.1989

Granulocyte macrophage-colony stimulating factor Leucomax

Treatment of chronic lymphocytic leukemia to increase granulocyte count. 04.05.1990

Granulocyte macrophage-colony stimulating factor Leucomax Treatment of myelodysplastic syndrome. 07.08.1989

Granulocyte macrophage-colony stimulating factor Leucomax

Treatment of neutropenia associated with bone marrow transplants. 12.12.1989

Granulocyte macrophage-colony stimulating factor Leucomax Treatment of neutropenia due to hairy cell leukemia. 03.05.1990

Group B streptococcus immune globulin

Treatment of neonates for disseminated group B streptococcal infection. 08.05.1990

Growth hormone releasing factor

For the long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion. 07.08.1989

Guanethidine monosulfate Ismelin

Treatment of moderate to severe reflex sympathetic dystrophy and causalgia. 06.01.1986

Guanfacine Tenex Treatment of fragile X syndrome. 05.08.1999

Gusperimus Spanidin Treatment of acute renal graft rejection episodes. 27.06.1996

Halofuginone Stenorol Treatment of systemic sclerosis. 07.02.2000

heat killed Mycobacterium w immunomodulator CADI Mw Active tuberculosis 03.09.2004

heat killed mycobacterium w immunomodulator CADI Mw

Adjuvant to multi-drug therapy in the management of multibacillary leprosy 21.11.2002

Heme arginate Normosang Treatment of symptomatic stage of acute porphyria. 10.03.1988

Heme arginate Normosang Treatment of myelodysplastic syndromes. 01.03.1994

Hemin and zinc mesoporphyrin Hemex Treatment of acute porphyric syndromes. 20.12.1993

Hemoximer (pyridoxalated hemoglobin polyoxyethylene) Treatment of cardiogenic shock 18.12.2007

Heparin Treatment of cystic fibrosis 03.11.2005

Heparin sodium Treatment of cystic fibrosis 29.06.2006

Heparin-binding epidermal growth factor-like growth factor

Prevention and treatment of necrotizing enterocolitis (NEC) in preterm infants with birth weight less than 1,500 grams 18.09.2006

Hepatitis B immune globulin intravenous (human) Nabi-HB

Prophylaxis against hepatitis B virus reinfection in liver transplant patients. 08.03.1995

Hepatitis C virus immune globulin (human) Civacir(tm)

Prophylaxis of hepatitis C infection in liver transplant recipients. 14.11.2002

HepeX-BFor the prevention of hepatitis B virus (HBV) reinfection in patients who have received a liver transplantation 15.07.2003

Herpes simplex virus gene Treatment of primary and metastatic brain tumors. 16.10.1992

Histamine Maxamine

For use as an adjunct to cytokine therapy in the treatment of malignant melanoma. 01.02.2000

Histamine Ceplene

Adjunct to cytokine therapy in the treatment of acute myeloid leukemia. 15.12.1999

HistrelinTreatment of acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. 03.05.1991

HIV neutralizing antibodies Immupath Treatment of acquired immunodeficiency syndrome. 24.03.1992

HLA-B7/Beta2M DNA Lipid (DMRIE/DOPE) Complex Allovectin-7

Treatment of invasive and metastatic melanoma (Stages II, III, and IV). 30.09.1999

homoharringtonine Treatment for chronic myelogenous leukemia 08.02.2002

HPA-23 Treatment of acquired immunodeficiency syndrome. 17.07.1985

HPV-16 cancer therapeutic trojan peptide vaccine

Treatment of HPV-16 expressing head and neck squamous cell carcinoma. 12.01.2009

Hsp E7 Treatment of recurrent respiratory papillomatosis (RRP) 19.03.2001

Hu1D10, humanized monoclonal antibody Remitogen

For use in the treatment of 1D10+ B cell non-Hodgkin's lymphoma 28.11.2001

Human acid precursor alpha-glucosidase, recombinant Treatment of glycogen storage disease type II. 10.09.1996Human alpha 2,6 sialyltransferase adenoviral gene therapy

Treatment of patients with invasive (malignant) brain and central nervous system tumors lacking alpha 2,6 sialyltransferase. 04.04.2005

Human anti-CD30 monoclonal antibody Treatment of Hodgkin's disease 27.09.2004

human anti-CD4 monoclonal antibody HuMax-CD4 Treatment of mycosis fungoides 13.08.2004

human anti-cellular adhesion molecule-1 monoclonal antibody Treatment of multiple myeloma 29.07.2008

Human anti-integrin receptor av monoclonal antibody Treatment of patients with angiosarcoma 05.05.2005human anti-integrin receptor avb3/avb5 monoclonal antibody

Treatment of patients with high-risk stage II, stage III, and stage IV malignant melanoma 01.12.2004

human anti-transforming growth factor beta 1 monoclonal antibody Treatment of systemic sclerosis 11.01.2002

human anti-transforming growth factor-B1,2,3 Treatment of idiopathic pulmonary fibrosis 09.07.2004Human autologous bone-forming cell derived from bone marrow stem cells Treatment of osteonecrosis 24.03.2008

human coagulation factor XI Hemoleven Treatment of severe congential Factor XI deficiency. 08.11.2007

Human cytomegalovirus immunoglobulin

Prevention of congenital cytomegalovirus (CMV) infection following primary CMV infection in pregnant women 20.12.2006

Human factor X Treatment of hereditary factor X deficiency 08.11.2007

human gammaglobulin

Treatment of gastrointestinal disturbances (to include constipation, diarrhea, and abdominal pain) associated with regression-onset autism in pediatric patients. 16.09.2002

human gammaglobulin Treatment of idiopathic inflammatory myopathies 14.11.2003

human gammaglobulin Treatment for juvenile rheumatoid arthritis 25.05.2001

Human IgM monoclonal antibody (C-58) To CMV Centovir

Prophylaxis of cytomegalovirus infections in bone marrow transplant patients. 07.08.1989

Human IgM monoclonal antibody (C-58) To CMV Centovir

Treatment of cytomegalovirus infections in allogenic bone marrow transplant patients. 07.08.1989

Human immune globulin Xepol Treatment of post-polio syndrome 29.03.2006

Human immunodeficiency virus immune globulin Treatment of AIDS. 21.11.1989

Human immunodeficiency virus immune globulin

Treatment of HIV-infected pregnant women and infants of HIV-infected mothers. 25.03.1992

Human immunodeficiency virus immune globulin Hivig Treatment of HIV-infected pediatric patients. 04.01.1995Human immunoglobin anti-CD30 monoclonal antibody Treatment of CD30+ T-cell lymphoma 10.01.2006Human immunoglobulin (IgG1k)antiCTLA-4 monoclonal antibody

Treatment of high risk Stage II, Stage III, and Stage IV melanoma 03.06.2004

human leukocyte-derived cytokine mixture

Neoadjuvant therapy in patients with squamous cell carcinoma of the head and neck 07.07.2005

Human monoclonal antibody against platelet-derived growth factor D

To slow the progression of IgA nephropathy and delay kidney failure in patients affected by the disease. 02.11.2004

Human monoclonal antibody directed against serotype 011 Pseudomonas aeruginosa Aerumab 11

Treatment of hospital acquired pneumonia caused by serotype 011 positive Pseudomonas aeruginosa 18.09.2006

Human monoclonal antibody of the Ig1/k-isotype against human interleukin-1 beta Treatment of cryopyrin-associated periodic syndromes 18.12.2007

Human monoclonal antibody targeting CC-chemokine ligand 2 Treatment of pancreatic cancer 24.10.2006Human plasma coagulation Factor VIII and human plasma von Willebrand Factor Wilate

Treatment of von Willebrand disease except for surgical and/or invasive procedures in patients with von Willebrand disease in whom desmopressin is either ineffective or contraindicated 18.04.2007

Human prothrombin complex concentrate Octaplex

Reversal of anticoagulation therapy in patients needing treatment of serious or life threatening bleeding and/or needing urgent surgery or invasive procedures 01.02.2008

human recombinant fusion protein Treatment of hypophosphatasia 12.09.2008Human telomerase reverse transcriptase peptide vaccine Treatment of pancreatic cancer 20.07.2006

Human T-lymphotropic virus type III Gp160 antigens Vaxsyn HIV-1 Treatment of AIDS. 20.11.1989

Human umbilical tissue-derived cells Treatment of retinitis pigmentosa 13.03.2006

Humanized anti-CD2 monoclonal antibody Treatment of graft-versus-host disease. 13.11.1998

Humanized anti-CD3 monoclonal antibody Treatment of recent-onset Type I diabetes 29.09.2006humanized anti-human CD16 monoclonal antibody Treatment of adult idiopathic thrombocytopenic purpura 21.03.2005

Humanized anti-human CD2 MAb MEDI-507

For the induction of donor-specific immunologic unresponsiveness resulting in prophylaxis of organ rejection without the need for chronic 17.09.1998

Humanized anti-tac Zenapax

Prevention of acute graft-vs-host disease following bone marrow transplantation. 05.03.1993

humanized IgG2 antibodyTreatment of vaso-occlusive crisis in patients with sickle cell disease. 22.07.2008

Humanized MAb (IDEC-131) to CD40L Treatment of systemic lupus erythematosus. 09.02.1999

humanized monoclonal antibody against Shiga-like toxin II

To prevent the development of or to decrease the incidence and severity of hemolytic uremic syndrome and associated sequelae of Shiga-like toxin-producing E. coli. 12.09.2001

Humanized monoclonal antibody to the high affinity folate alpha receptor Treatment of ovarian cancer 16.06.2006humanized monocloncal antibody against human integrin alphaVbeta6

Treatment of fibrosis-associated chronic allograft nephropathy in kidney transplant patients. 18.06.2008

hyaluronic acidTreatment of emphysema in patients due to alpha-1 antitrypsin deficiency 19.03.2002

Hydralazine

Treatment of severe intrapartum hypertension (diastolic blood pressure greater than or equal to 110 or systolic blood pressure greater than or equal to 160) associated 09.04.2004

hydrocortisone modified release tabs DuoCort Treatment of adrenal insufficiency 18.06.2008

Hydroxocobalamin Treatment of acute cyanide poisoning 22.09.2000

Hydroxycobalamin/sodium thiosulfate Treatment of severe acute cyanide poisoning. 04.10.1985

hydroxyurea Treatment of pediatric patients with sickle cell anemia. 15.04.2005

Hypericin Treatment of glioblastoma multiforme. 03.08.2000

Hypericin Treatment of cutaneous T-cell lymphoma. 07.02.2000

I(131)-TM-601 (chlorotoxin) Treatment of malignant glioma 14.02.2002

Iboctadekin Treatment of renal cell carcinoma 03.06.2005

Ibuprofen i.v. solution Salprofen Prevention of patent ductus arteriosus. 29.10.1996

icatibant Treatment of burn patients hospitalized with burn-induced edema 05.05.2004

icatibant Treatment of angioedema 25.11.2003

Idarubicin Idamycin Treatment of chronic myelogenous leukemia. 02.12.1992

Idarubicin Idamycin Treatment of myelodysplastic syndromes. 01.12.1992

Idarubicin HCl for injection Idamycin

Treatment of acute lymphoblastic leukemia in pediatric patients. 12.02.1991

idebenone Treatment of Leber's hereditary optic neuropathy. 31.10.2006

idebenone Treatment of Duchenne muscular dystrophy 16.02.2007

Idebenone Treatment of Friedreich's ataxia 25.03.2004

Idoxuridine Treatment of nonparenchymatous sarcomas. 08.04.1996

IDUA-HIRMAb fusion protein AGT-181 Treatment of mucopolysaccharidosis Type 1 (MPS) 10.01.2008

Ifosfamide Ifex Treatment of bone sarcomas 07.08.1985

Ifosfamide Ifex Treatment of soft tissue sarcomas. 07.08.1985

IL13-PE38QQR Treatment of malignant glioma 02.11.2001

IL-4 Pseudomonas Toxin Fusion Protein (IL-4(38-37)-PE38KDEL) Treatment of astrocytic glioma. 06.04.2000

Iloprost solution for infusionTreatment of Raynaud's phenomenon secondary to systemic sclerosis. 21.09.1989

Iloprost solution for infusion Treatment of heparin-associated thrombocytopenia. 14.05.1990

Imciromab pentetate Myoscint

Detecting early necrosis as an indication of rejection of orthotopic cardiac transplants. 25.01.1989

imexon Amplimexon Treatment of ovarian cancer. 12.08.2005

Imexon Treatment of multiple myeloma. 08.11.1996

Imexon Treatment of pancreatic adenocarcinoma 01.11.2003

Imexon Treatment of metastatic malignant melanoma 03.08.2001Immortalized human liver cells found in the extracorporeal liver assist device ELAD

Treatment of fulminant hepatic failure (acute liver failure) 16.07.2004

Immune Globulin (Human) containing high titers of West Nile virus antibodies Omr-IgG-am (tm) 5% (Treatment of the West Nile virus infection 17.03.2004

Immune Globulin Intravenous (human) Carimune NF Treatment for Guillain Barre Syndrome 04.05.2004Immune globulin intravenous (human) Gammagard Liquid Treatment of multifocal motor neuropathy 20.07.2006

Immune globulin intravenous (human) Immune Globulin IntravTreatment of patients with acute myocarditis. 22.11.1993

Immune globulin intravenous (human) Iveegam, Immuno Treatment of polymyositis/dermatomyositis. 13.10.1992

Immune globulin intravenous (human) Iveegam, Immuno Treatment of juvenile rheumatoid arthritis. 16.12.1992

Immune Globulin Subcutaneous (Human) Vivaglobin P (proposed

Treatment of patients with primary immune deficiency (PID) that are intolerant to immune globulin intravenous (IGIV) due to severe adverse events or poor venous access 22.09.2004

Implitapide Treatment of homozygous familial hypercholesterolemia 13.08.2004

ImplitapideTreatment of patients with Fredrickson type I or V hyperlipoproteinemia 19.08.2004

Imported fire ant venom, allergenic extract

For skin testing of victims of fire ant stings to confirm fire ant sensitivity and if positive, for use as immunotherapy for the prevention of IgE-mediated anaphylactic reactions. 12.05.1992

Inalimarev and falimarev Treatment of adenocarcinoma of the pancreas 10.01.2006

Indium In 111 murine monoclonal antibody FAB to myosin Myoscint To aid in the diagnosis of myocarditis. 07.08.1989

Indium In-111 altumomab pentetate Hybri-ceaker

Detection of suspected and previously unidentified tumor foci of recurrent colorectal carcinoma. 06.02.1990

Indium-111 pentetreotide NeuroendoMedix Treatment of neuroendocrine tumors 16.06.2006

infliximab Remicade Treatment of juvenile rheumatoid arthritis 23.10.2002

infliximab Remicade Treatment of giant cell arteritis 06.05.2003

Infliximab REMICADE

Treatment of pediatric (0 to 16 years of age) ulcerative colitis 12.11.2003

Infliximab Remicade Treatment of chronic sarcoidosis 21.05.2003

INGN 201 ADVEXIN Treatment of head and neck cancer 27.01.2003

INH-A00021 Veronate

Reduction (prevention) of nosocomial bacteremia caused by staphylococci in very low birth weight infants. 13.06.2001

inolimomab Leukotac Treatment of graft versus host disease 23.10.2002

Inosine pranobex Isoprinosine Treatment of subacute sclerosing panencephalitis. 20.09.1988

Interferon alfa-2a (recombinant) Roferon-A Treatment of renal cell carcinoma. 18.04.1988

Interferon alfa-2a (recombinant) Roferon-A

For the treatment of metastatic malignant melanoma in combination with Teceleukin. 11.05.1990

Interferon alfa-2a (recombinant) Roferon-A

For the concomitant administration with Teceleukin for the treatment of metastatic renal cell carcinoma. 02.05.1990

Interferon alfa-2a (recombinant) Roferon-A

For the concomitant administration with fluorouracil for the treatment of advanced colorectal cancer. 14.05.1990

Interferon alfa-2a (recombinant) Roferon-A

For use in combination with fluorouracil for the treatment of esophageal carcinoma. 27.10.1989

Interferon alfa-2b (recombinant) Intron A Treatment of acute hepatitis B. 17.11.1988

Interferon alfa-2b (recombinant) Intron A Treatment of primary malignant brain tumors. 13.05.1988

Interferon alfa-2b (recombinant) Intron A Treatment of carcinoma in situ of the urinary bladder. 10.08.1988

Interferon alfa-2b (recombinant) Intron A Treatment of invasive carcinoma of the cervix. 18.04.1988

Interferon alfa-2b (recombinant) Intron A Treatment of ovarian carcinoma. 03.08.1987

Interferon alfa-2b (recombinant) Intron A Treatment of chronic myelogenous leukemia. 22.06.1987

Interferon alfa-2b (recombinant) Intron A Treatment of metastatic renal cell carcinoma. 22.06.1987

Interferon alfa-2b (recombinant) Intron A Treatment of laryngeal (respiratory) papillomatosis. 17.08.1988

Interferon alfa-2b (recombinant) Intron A Treatment of chronic delta hepatitis. 04.05.1990

Interferon alfa-nl Wellferon

Treatment of human papillomavirus in patients with severe resistant/recurrent respiratory (laryngeal) papillomatosis. 16.10.1987

Interferon alfa-nl Wellferon Treatment of AIDS related Kaposi's sarcoma. 25.08.1986

Interferon beta (recombinant) R-IFN-beta

For the systemic treatment of metastatic renal cell carcinoma. 12.02.1991

Interferon beta (recombinant) r-HuIFN-beta

For the intralesional and/or systemic treatment of AIDS-related Kaposi's sarcoma. 09.05.1991

Interferon beta (recombinant) r-HuIFN-beta

For the systemic treatment of cutaneous T-cell lymphoma. 18.04.1991

Interferon beta, recombinant human Betaseron Treatment of acquired immunodeficiency syndrome. 15.11.1988

Interferon beta-1a Rebif

Treatment of patients with secondary progressive multiple sclerosis. 11.03.1996

interferon Beta-1a Avonex Treatment of juvenile rheumatoid arthritis. 14.10.1998

Interferon beta-1a (recombinant human) Treatment of acute non-A, non-B hepatitis. 24.07.1992

Interferon beta-1a (recombinant) r-HuIFN-beta

For the systemic treatment of cutaneous malignant melanoma. 03.04.1991

Interferon beta-1a (recombinant) Rebif

Treatment of symptomatic patients with AIDS including all patients with CD4 T-cell counts less than 200 cells per mm3. 02.12.1992

Interferon gamma Treatment of idiopathic pulmonary fibrosis 11.10.2007

interferon gamma-1b Actimmune Treatment of idiopathic pulmonary fibrosis 12.09.2002

Interferon gamma-1b Actimmune Treatment of renal cell carcinoma. 04.12.1995

Interferon-alfa-1b Treatment of multiple myeloma 17.04.2001Interleukin-1 alpha, human recombinant For hematopoietic potentiation in aplastic anemia. 17.06.1991

Interleukin-1 alpha, human recombinant

For the promotion of early engraftment in bone marrow transplantation. 17.06.1991

Interleukin-1 receptor antagonist, human recombinant Antril Treatment of juvenile rheumatoid arthritis. 23.09.1991

Interleukin-1 receptor antagonist, human recombinant Antril

Prevention and treatment of graft versus host disease in transplant recipients. 16.10.1992

Interleukin-1 TrapTreatment of Still's disease including juvenile rheumatoid arthritis and adult-onset Still's disease 04.04.2005

Interleukin-2 Teceleukin

In combination with interferon alfa-2a for the treatment of metastatic malignant melanoma. 11.05.1990

Interleukin-2 Teleleukin Treatment of metastatic malignant melanoma. 06.02.1990

Interleukin-2 Teceleukin Treatment of metastatic renal cell carcinoma. 05.02.1990

Interleukin-2 Teceleukin

In combination with interferon alfa-2a for the treatment of metastatic renal cell carcinoma. 03.05.1990

Interleukin-3 human (recombinant)Promotion of erythropoiesis in Diamond-Blackfan anemia (congenital pure red cell aplasia). 20.05.1991

Interleukin-3, human, recombinant

For sequential administration with sargramostim to accelerate neutrophil and platelet recovery in patients undergoing autologous bone marrow transplantation for 30.09.1993

Intraoral fluoride releasing system IFRS

Prevention of dental caries due to radiation-induced xerostomia in patients with head and neck cancer 31.07.2001

Intravenous immune globulin VitiGam Treatment of Stage IIB to IV malignant melanoma 26.07.2007

Intravenous immune globulin (human) 10% Octagam Treatment of stiff-person syndrome 31.07.2008

iobenguane I 131 Treatment of neuroendocrine tumors 05.07.2007

Iobenguane I 131 Azedra Ultratrace Treatment of neuroendocrine tumors 18.01.2006

Iobenguane Sulfate I-123 OmaClear

For scintigraphic detection, localization and staging of neuroblastoma. 17.10.2005

iobenguane sulfate I-123 OmaClear

For the detection, localization, and staging of pheochromocytomas. 21.10.2005

Iodine 131 6B-iodomethyl-19-norcholesterol For use in adrenal cortical imaging. 01.08.1984

Iodine I 123 murine monoclonal antibody to alpha-fetoprotein

Detection of alpha-fetoprotein producing germ cell tumors. 30.09.1988

Iodine I 123 murine monoclonal antibody to alpha-fetoprotein

Detection of hepatocellular carcinoma and hepatoblastoma. 30.09.1988

Iodine I 123 murine monoclonal antibody to hCG

Detection of hCG producing tumors such as germ cell and trophoblastic cell tumors. 07.11.1988

Iodine I 131 bis(indium-diethylenetriaminepentaacetic acid)tyrosyllysine/hMN-14 x m734 Pentacea Treatment of small-cell lung cancer. 22.02.2000

Iodine I 131 Lym-1 Monoclonal Antibody Treatment of B-cell lymphoma. 02.11.1987

Iodine I 131 murine monoclonal antibody IgG2a to B cell Immurait, Ll-2-I-131 Treatment of B-cell leukemia and B-cell lymphoma. 18.09.1989

Iodine I 131 murine monoclonal antibody to alpha-fetoprotein

Treatment of alpha-fetoprotein producing germ cell tumors. 30.09.1988

Iodine I 131 murine monoclonal antibody to alpha-fetoprotein

Treatment of hepatocellular carcinoma and hepatoblastoma. 30.09.1988

Iodine I 131 murine monoclonal antibody to hCG

Treatment of hCG producing tumors such as germ cell and trophoblastic cell tumors. 07.11.1988

Iodine I-131 radiolabeled chimeric MAb tumor necrosis treatment 131IchTNT-1

Treatment of glioblastoma multiforme and anaplastic astrocytoma. 12.02.1999

irofulven Treatment of renal cell carcinoma. 27.07.1999

irofulven Treatment of ovarian cancer. 06.07.1999

Isobutyramide Treatment of sickle cell disease and beta thalassemia. 25.05.1994

Isobutyramide Isobutyramide oral solu

Treatment of beta-hemoglobinopathies and beta-thalassemia syndromes. 18.12.1992

isofagomine tartrate Treatment of Gaucher disease 10.01.2006

Itraconazole suspension Topical treatment of fungal otitis externa (otomycosis) 30.10.2008

IV Sotalol So-Aqueous

For ventricular tachycardia, ventricular fibrillation, or the maintenance of sinus rhythm in patients converted from atrial fibrillation or atrial flutter when oral administration is not possible. 25.07.2008

JAK tyrosine kinase inhibitor Treatment of myelofibrosis 05.09.2008

Japanese encephalitis vaccine (live, attenuated) Prevention of Japanese encephalitis. 19.05.1999

Ketoconazole Nizoral

For use with cyclosporine A to diminish the nephrotoxicity induced by cyclosporine in organ transplantation. 27.03.1991

kit for the preparation of technetium Tc99m sulfur colloid

For localization of sentinel lymph nodes in patients with melanoma. 17.03.2009

L-2-oxothiazolidine-4-carboxylic acid Procysteine Treatment of adult respiratory distress syndrome. 14.06.1994

L-2-oxothiazolidine-4-carboxylic acid Procysteine Treatment of amyotrophic lateral sclerosis. 30.07.1996

L-5-hydroxytryptophan Treatment of tetrahydrobiopterin deficiency. 20.01.1999

Lactic acid Aphthaid

Treatment of severe aphthous stomatitis in severely, terminally immunocompromised patients. 29.06.1999

lactic acid bacteria (Lactobacilli, Bifidobacteria, and Steptococci) Treatment of active chronic pouchitis 15.01.2002lactic acid bacteria (Lactobacilli, Bifidobacteria, and Streptococcus species)

Prevention of disease relapse in patients with chronic pouchitis 15.01.2002

Lactobin Lactobin

Treatment of AIDS-associated diarrhea unresponsive to initial antidiarrheal therapy. 12.09.1990

L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal

Treatment of Duchenne and Becker muscular dystrophy 18.01.2006

laromustine Onrigin Treatment of acute myelogenous leukemia 21.10.2004

Latrodectus immune F(ab)2 Aracmyn Treatment of black widow spider envenomations 18.06.2001

L-baclofen Treatment of trigeminal neuralgia. 13.07.1990

L-Baclofen Neuralgon

Treatment of intractable spasticity in children with cerebral palsy. 30.01.1992

L-baclofen Neuralgon

Treatment of intractable spasticity associated with spinal cord injury or multiple sclerosis. 17.12.1991

L-Baclofen Treatment of trigeminal neuralgia. 06.01.1998

L-cycloserine Treatment of Gaucher's disease. 01.08.1989

L-cysteineFor the prevention and lessening of photosensitivity in erythropoietic protoporphyria. 16.05.1994

LeflunomidePrevention of acute and chronic rejection in patients who have received solid organ transplants. 18.10.1996

lenalidomide Revlimid(r) Treatment of mantle cell lymphoma 27.04.2009

lenalidomide Revlimid Treatment of chronic lymphocytic leukemia. 17.01.2007

Lentiviral vector encoded with a human beta-globin gene plasmid Thalagen

Treatment of beta-thalassemia major and beta-thalassemia intermedia 11.01.2006

Lestaurtinib Treatment of acute myeloid leukemia 24.03.2006

Leucovorin calcium Wellcovorin

For use in combination with 5-fluorouracil for the treatment of metastatic colorectal cancer. 23.06.1988

leukocyte interlukin Multikine

Neoadjuvant therapy in patients with squamous cell carcinoma of the head and neck 04.05.2007

LeupeptinFor use as an adjunct to microsurgical peripheral nerve repair. 18.09.1990

Levocabastine HCl ophthalmic suspension 0.05% Treatment of vernal keratoconjunctivitis. 29.02.1988

Levocarnitine Carnitor

Treatment of manifestations of carnitine deficiency in patients with end stage renal disease who require dialysis. 24.11.1986

Levocarnitine Carnitor

For the treatment of secondary carnitine deficiency in valproic acid toxicity. 15.11.1989

Levocarnitine Carnitor

For the prevention of secondary carnitine deficiency in valproic acid toxicity. 15.11.1989

Levocarnitine Carnitor

Treatment of zidovudine-induced mitochondrial myopathy. 07.04.1997

Levocarnitine Carnitor Treatment of pediatric cardiomyopathy. 22.11.1993

Levodopa and carbidopa Duodopa Treatment of late stage Parkinson's disease. 18.01.2000

LevofloxacinPseudomonas aeruginosa and other bacteria in patients with cystic fibrosis patients 27.02.2008

L-glutamine Treatment of sickle cell disease 01.08.2001

L-glutamyl-L-tryptophan Treatment of AIDS-related Kaposi's sarcoma. 20.10.1999

liarozole The treatment of congenital ichthyosis 18.06.2004

Lintuzumab Treatment of myelodysplastic syndrome 20.03.2007

lintuzumab Treatment of acute myeloid leukemia. 30.01.2007

lintuzumab Zamyl Treatment of acute myelogenous leukemia 09.09.2002

Lipid/DNA human cystic fibrosis gene Treatment of cystic fibrosis. 08.04.1996

Liposomal amphotericin B AmBisome Treatment of histoplasmosis. 10.12.1996

Liposomal annamycin Treatment of acute myeloid leukemia 17.06.2005

Liposomal annamycin Treatment of acute lymphoblastic leukemia 17.06.2005

Liposomal ciprofloxacin Management of bronchiectasis 27.12.2006Liposomal ciprofloxacin for inhalation Management of cystic fibrosis 19.04.2006

Liposomal cisplatin LipOva-Pt Treatment of ovarian cancer 23.05.2006

Liposomal cyclosporin A Cyclospire

For aerosolized administration in the prevention and treatment of lung allograft rejection and pulmonary rejection events associated with bone marrow transplantation. 30.04.1998

liposomal cyclosporine for inhalation Prevention of bronchiolitis obliterans. 24.06.2008

Liposomal doxorubicin hydrochloride Sarcodoxome Treatment of soft tissue sarcomas 27.12.2006

liposomal gadodiamide Treatment of glioma. 12.11.2008

Liposomal N-Acetylglucosminyl-N-Acetylmuramly-L-Ala-D-isoGln-L-Ala -gylcerolidpalmitoyl ImmTher Treatment of osteosarcoma. 10.06.1998Liposomal N-Acetylglucosminyl-N-Acetylmuramly-L-Ala-D-isoGln-L-Ala -gylcerolidpalmitoyl ImmTher Treatment of Ewing's sarcoma. 10.06.1998

Liposomal nystatin Nyotran Treatment of invasive fungal infections. 13.06.2000liposomal p-ethoxy growth receptor bound protein-2 antisense product Treatment of chronic myelogenous leukemia 05.12.2003

Liposomal prostaglandin E1 injection Treatment of acute respiratory distress syndrome. 25.04.1996

liposomal topotecan hydrochloride Treatment of gliomas 30.10.2008Liposomal-cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane-Pt (II) Aroplatin Treatment of malignant mesothelioma. 01.09.1999

Liposome encapsulated recombinant interleukin-2 Treatment of brain and CNS tumors. 25.11.1991

Liposome encapsulated recombinant interleukin-2 Treatment of cancers of the kidney and renal pelvis 20.06.1994

LisofyllineTreatment of patients undergoing induction therapy for acute myeloid leukemia. 10.06.1999

L-leucovorin Isovorin

For use in combination chemotherapy with the approved agent 5-fluorouracil in the palliative treatment of metastatic adenocarcinoma of the colon and rectum. 18.12.1990

Loxoribine Treatment of common variable immunodeficiency. 24.02.1992

L-threonineTreatment of spasticity associated with familial spastic paraparesis. 24.07.1992

L-threonine Threostat Treatment of amyotrophic lateral sclerosis. 06.02.1989

L-threonyl-L-prolyl-L-prolyl-L-threonine

Treatment of neuropathic pain associated with spinal cord injury 26.04.2005

L-tyrosine-L-serine-L-leucine CMS-024 Treatment of hepatocellular carcinoma. 10.09.2004

Lucinactant Surfaxin

Prevention of bronchopulmonary dysplasia in premature infants 23.05.2006

Lucinactant Surfaxin

Treatment of bronchopulmonary dysplasia in premature infants. 21.10.2005

Lucinactant Surfaxin

Treatment of meconium aspiration syndrome in newborn infants 30.07.1996

Lucinactant Surfaxin

Treatment of acute respiratory distress syndrome in adults. 17.07.1995

Lucinactant Surfaxin

Treatment of respiratory distress syndrome in premature infants. 18.10.1995

Lysine acetylsalicylate injectableTreatment of pain and fever secondary to sickle cell disease crisis. 01.08.1989

lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase

Treatment of mucopolysaccharidosis Type IVA (Morquio Syndrome) 10.09.2008

lyso-thermosensitive lipsomal doxorubicin ThermoDox (r) For treatment of hepatocellular carcinoma. 17.03.2009

macitentan Treatment of idiopathic pulmonary fibrosis. 14.04.2009

Mafosfamide Treatment of neoplastic meningitis 21.01.2003

MAGE-A3 cancer therapeutic Trojan peptide vaccine

Treatment of MAGE-A3 expressing head and neck squamous cell carcinoma 24.11.2008

Mammalian target of rapamcyin (mTOR) inhibitor Treatment of soft tissue sarcoma 12.08.2005

Manganese superoxide dismutase mimetic

Prevention of radiation- or chemotherapy-induced oral mucositis in cancer patients 27.02.2008

Mannitol Bronchitol

For use to facilitate clearance of mucus in patients with bronchiectasis and in patients with cystic fibrosis at risk for bronchiectasis 11.02.2005

mannopentaose phosphate sulfateTreatment of high-risk Stage II, Stage III, and Stage IV melanoma 27.04.2004

maribavirPrevention of cytomegalovirus viremia and disease in the populations at risk. 01.02.2007

Marijuana Treatment of HIV-associated wasting syndrome. 25.05.1999

Matrix metalloproteinase inhibitor Galardin Treatment of corneal ulcers. 05.12.1991

MaxAdFVIII Treatment of Hemophilia A 03.03.2003

Mazindol Sanorex Treatment of Duchenne muscular dystrophy. 08.12.1986

Mecamylamine Inversine Treatment of Tourette's syndrome. 14.10.1998

mecasermin Iplex Treatment of myotonic dystrophy 03.12.2007

Mecasermin Myotrophin Treatment of amyotrophic lateral sclerosis. 05.08.1991

meclorethamine or nitrogen mustard Treatment of mycosis fungoides. 12.08.2004

MEDI-522 Vitaxin

For the treatment of of stage IIb, stage IIc, stage III and stage IV melanoma 14.04.2004

Medroxyprogesterone acetate Hematrol Treatment of immune thrombocytopenic purpura. 22.02.2001

Mefloquine HCl Mephaquin Prevention of chloroquine-resistant Falciparum malaria. 22.07.1987

Mefloquine HCl Mephaquin Treatment of chloroquine-resistant Falciparummalaria. 22.07.1987

Melanoma autologous dendritic cell vaccine

Treatment of stage IIIb through IV metastatic melanoma 06.09.2006

Melanoma cell vaccine Canvaxin Treatment of invasive melanoma. 13.10.1994

Melanoma peptide vaccineTreatment of HLA-A2+ patients with stage IIB, IIC, III, and IV malignant melanoma 29.03.2005

Melanoma vaccine Melacine Treatment of stage III - IV melanoma. 20.12.1989

Melatonin Circadin

Treatment of non-24-hour sleep-wake disorder in blind individuals without light perception 09.07.2004

MelatoninTreatment of circadian rhythm sleep disorders in blind people with no light perception. 15.11.1993

melphalan High dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation 24.11.2008

Melphalan Alkeran for Injection

For use in hyperthermic regional limb perfusion to treat metastatic melanoma of the extremity. 03.03.1992

melphalan hydrochloride Treatment of patients with ocular (uveal) melanoma. 12.11.2008

melphalan hydrochloride Treatment of patients with cutaneous melanoma. 12.11.2008

mepivacaine Treatment of postherpetic neuralgia 08.01.2007

Mepivacaine Treatment of painful HIV-associated neuropathy 18.10.2006

mepolizumabFor first-line treatment in patients with hypereosinophilic syndrome 28.05.2004

Meropenem Merrem IV

Management of acute pulmonary exacerbations, in cystic fibrosis patients, due to respiratory tract infection with susceptible organisms. 27.04.2000

mesalamine; 5-aminosalicylic acid Lialda

Treatment of active, mild to moderate ulcerative colitis in children 5 to 17 years 27.02.2008

Mesna

Inhibition of the urotoxic effects induced by oxazaphosphorine compounds such as cyclophosphamide. 16.12.1987

Methionine/L-methionine Treatment of AIDS myelopathy. 21.08.1996

methotrexate Rheumatrex Treatment of juvenile rheumatoid arthritis. 23.08.1993

Methotrexate with laurocapram Methotrexate/azone Topical treatment of mycosis fungoides. 15.10.1990

Methoxsalen Uvadex

For use in conjunction with the UVAR photopheresis system to treat graft versus host disease. 14.10.1998

metreleptinTreatment of metabolic disorders secondary to lipodystrophy 22.08.2001

metreleptinTreatment of leptin deficiency secondary to generalizedlipodystrophy and partial familial lipodystrophy 22.08.2001

metronidazole Treatment of pouchitis 17.09.2008

Metronidazole Metrogel Treatment of perioral dermatitis. 24.10.1991

Metronidazole (topical) Flagyl

Treatment of grade III and IV, anaerobically infected, decubitus ulcers. 24.11.1987

Metronidazole 10% ointment Topical treatment of active perianal Crohn's disease 08.11.2007

metyrosine Demser

Treatment of velocardiofacial syndrome associated psychosis. 25.07.2008

mibefradil Treatment of pancreatic cancer. 16.10.2008

Mibefradil Treatment of ovarian cancer 15.06.2007

Microbubble contrast agent Filmix Neurosonograph

Intraoperative aid in the identification and localization of intracranial tumors. 16.11.1990

Microvesiculated modified glycosylated tissue factor

Treatment of cutaneous bleeding episodes in patients with von Willebrand disease. 11.10.2007

Microvesiculated modified glycosylated tissue factor

Treatment of non-life threatening, mild to severe bleeding episodes due to cutaneous injuries or dental procedures in hemophiliac patients 25.01.2007

Midazolam HCl

Treatment of bouts of increased seizure activity in selected refractory patients with epilepsy who are on stable regimens of anti-epileptic drugs and who require intermittent use of midazolam 08.05.2006

mifamuritide Junovan Treatment of osteosarcoma 05.06.2001

MifepristoneTreatment of Cushing's syndrome secondary to ectopic ACTH secretion 07.02.2005

mifepristone Corlux

Treatment of the clinical manifestations of endogenous Cushing's symdrome. 05.07.2007

miglustat Zavesca (r)

Treatment of the neurological manifestations of Niemann-Pick disease,type C. 12.11.2008

milatuzumab Treatment of chronic lymphocytic leukemia. 24.06.2008

milatuzumab Treatment of multiple myeloma 10.03.2008

miltefosine Miltex(r) / Impavido(r)

Topical treatment of cutaneous lymphoma encompassing cutaneous manifestations of T-cell lymphoma and B-cell lymphoma 18.03.2009

miltefosine Impavido Treatment of leishmaniasis. 10.10.2006

Minocycline HCl Minocin Intravenous Treatment of chronic malignant pleural effusion. 19.06.1992

Minocycline hydrochloride Treatment of sarcoidosis 28.03.2006

misoprostol GyMiso

Treatment of intrauterine fetal death not accompanied by complete expulsion of the products of conception in the second and third trimesters of pregnancy. 10.01.2005

Mitoguazone apep

including AIDS-related diffuse non-Hodgkin's lymphoma. 18.03.1994

MitolactolTreatment of invasive carcinoma of the uterine cervix

23.01.1989

MitolactolAs adjuvant therapy in the treatment of primary brain tumors. 12.07.1995

mitomycin-C Trabomycin

Treatment of refractory glaucoma as an adjunct to ab externo glaucoma surgery. 08.01.2008

Mitomycin-CTreatment of refractory glaucoma as an adjunct to ab externo glaucoma surgery. 20.08.1993

MN14 monoclonal antibody to carcinoembryonic antigen Cea-Cide Treatment of small cell lung cancer 18.09.1998

MN14 monoclonal antibody to carcinoembryonic antigen Cea-Cide Treatment of pancreatic cancer. 24.11.1998

Molgramostim Leucomax

Treatment of AIDS patients with neutropenia due to the disease, AZTor ganciclovir. 24.01.1989

Molgramostim Leucomax Treatment of aplastic anemia. 25.09.1989

monarsen Treatment of Myasthenia Gravis 14.11.2003Monoclonal Ab(murine) anti-idiotype melanoma-associated antigen Melimmune Treatment of invasive cutaneous melanoma. 19.09.1994

Monoclonal antibodies (murine or human) to B-cell lymphoma Treatment of B-cell lymphoma. 06.05.1986

Monoclonal antibody 17-1a Panorex Treatment of pancreatic cancer. 04.04.1988

monoclonal antibody 3F8 Treatment of neuroblastoma 16.09.2008Monoclonal antibody for immunization against lupus nephritis Treatment of lupus nephritis. 07.01.1993

Monoclonal antibody to cytomegalovirus (human)

Treatment of cytomegalovirus retinitis in patients with AIDS. 15.11.1991

Monoclonal antibody to cytomegalovirus (human)

Prophylaxis of cytomegalovirus disease in patients undergoing solid organ transplantation. 13.09.1991

Monoclonal antibody to hepatitis B virus (human)

Prophylaxis of hepatitis B reinfection in patients undergoing liver transplantation secondary to end-stage chronic hepatitis B infection. 17.06.1991

Monoclonal antibody-B43.13 Ovarex MAb-B43.13 Treatment of epithelial ovarian cancer. 25.11.1996

Monoclonal antiendotoxin antibody XMMEn-0e5

Treatment of patients with gram-negative sepsis which has progressed to shock. 04.11.1985

Monolaurin Glylorin Treatment of congenital primary ichthyosis. 29.04.1993

motexafin gadolinium Xcytrin

For use in conjunction with whole brain radiation for the treatment of brain metastases arising from solid tumors 27.01.2003

MTC-DOX for Injection Treatment of hepatocellular carcinoma 03.01.2001Mucoid exopolysaccharide Pseudomonas hyperimmune globulin MEP IGIV

Treatment of pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis. 09.01.1991

Mucoid exopolysaccharide Pseudomonas hyperimmune MEP IGIV

Pseudomonas aeruginosa in patients with cystic fibrosis. 07.11.1990

Multi-ligand somatostatin analogue

Treatment of patients with functional gastroenteropancreatic (GEP) neuroendocrine tumors (specifically, carcinoid, insulinoma, gastrinoma, somastatinoma, GRFoma, VIPoma and glucagonoma. 27.07.2004

Multi-vitamin infusion (neonatal formula)

For establishment and maintenance of total parenteral nutrition in very low birth weight infants. 12.12.1989

Murine MAb (Lym-1) and Iodine 131-I radiolabeled murine MAb (Lym-1) to human B-cell Oncolym Treatment of B-cell non-Hodgkin's lymphoma. 27.11.1998Murine MAb to polymorphic epithelial mucin, human milk fat globule 1 Theragyn Adjuvant treatment of ovarian cancer. 22.03.1999

Mx-dnG1 Rexin-G(R) Treatment for soft tissue sarcoma. 24.06.2008

Mx-dnG1 Rexin-G Treatment of osteosarcoma. 24.06.2008

Mx-dnG1 or Rexin-G retroviral vector REXIN-G Treatment of pancreatic cancer 15.08.2003

Mycobacterium avium sensitin RS-10

For use in the diagnosis of invasive Mycobacterium avium disease in immunocompetent individuals. 11.10.1995

Mycophenolate mofetil CellCept Treatment of pemphigus vulgaris 26.05.2006

Myelin Treatment of multiple sclerosis. 27.06.1991

myo-inositolPrevention of retinopathy of prematurity in preterm infants at risk for developing retinopathy of prematurity 07.04.2005

myristoylated recombinant SCR1-3 of human complement reseptor type I APT070

Prevention of delayed graft function in solid organ transplant 21.05.2003

N-((methyl-diazacyclohexyl-methylbenzamide)-asaphenyl- Treatment of malignant gastrointestinal stromal tumors. 20.04.2005N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'biphenyl]-2-yl]carbonyl]amino]-1- Treatment of homozygous familial hypercholesterolemia 23.10.2007N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3- Treatment of gastrointestinal stromal tumors 13.01.2005N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4- Treatment of patients with cystic fibrosis. 20.12.2006N-(2-amino-phenyl)-4-[(4-pyridin-3-yl-pyrimidin-2-ylamino)-methyl] Treatment of Hodgkin's lymphoma 08.08.2007N-(2-amino-phenyl)-4-[(4-pyridin-3-yl-pyrimidin-2-ylamino)-methyl] Treatment of acute myeloid leukemia 01.02.2008N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-(morpholin-4-yl)ethoxy) imidazo[2,1-b][1,3]benzothiazol-2- Treatment of acute myeloid leukemia 18.03.2009

N-(methyl-diazacyclohexyl-methylbenzamide)-azaphenyl-aminothiopyrrole) mesylate Treatment of multiple myeloma. 17.10.2005N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide Treatment of neuroblastoma 30.09.2004N-[3-(4',5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3S)-3-(dimethylamino)pyrrolidin-1-

Treatment of Philadelphia chromosome-positive chronic myelogenous leukemia. 27.12.2006

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl) urea Treatment of acute myelogenous leukemia 23.10.2007N-[4-(3-amino1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl)urea Treatment of hepatocellular carcinoma 23.05.2007N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide Treatment of stages IIB-IV melanoma 13.08.2004N-[4-(4-amino-2-ethyl-lH-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide Treatment of cutaneous T-cell lymphoma 24.03.2006N-[4-bromo-2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]-N'-[3,5-bis(trifluoromethyl)phenyl]urea Treatment of sickle cell disease 13.05.2002

N2'-Deacetyl-N2'-[4-methyl-4-(oxobuthyldithio)-1-oxopentyl]-maytansine-chimerized anti- Treatment of multiple myeloma 27.02.2008

nabumetone For treatment of pediatric juvenile rheumatoid arthritis. 05.05.2008

N-acetylcysteinate Lysine Nacystelyn Dry PowderFor the management of cystic fibrosis 27.12.2000

N-acetylcysteine Treatment of acute liver failure 09.09.2002

N-acetyl-glucosamine thiazoline Treatment of adult Tay-Sachs disease 06.02.2006

N-acetylprocainamide Napa

To lower the defibrillation energy requirement sufficiently to allow automatic implantable cardioverter defibrillator therapy in those patients who could otherwise not use the device. 23.03.1990

N-acetyl-procainamidePrevention of life-threatening ventricular arrhythmias in patients with documented procainamide-induced lupus. 10.12.1996

N-acetyl-sarcosyl-glycyl-L-valyl-D-alloisoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl_L- Treatment of soft tissue sarcoma 09.12.2003

N-adamantanyl-N'-Geranyl-ethylenediamine Treatment of tuberculosis. 16.10.2007

natural human lymphoblastoid interferon-alpha Treatment of polycythemia vera 18.11.2002

Natural human lymphoblastoid interferon-alpha Treatment of Behcet's disease. 18.01.2000

Natural human lymphoblastoid interferon-alpha

Treatment of papillomavirus warts in the oral cavity of HIV positive patients. 10.08.2000

NDROGE Treatment of postanoxic intention myoclonus. 01.11.1984

Nebacumab Centoxin

Treatment of patients with gram-negative bacteremia which has progressed to endotoxin shock. 01.10.1986

Neurotrophin-1Treatment of motor neuron disease/amyotrophic lateral sclerosis. 13.09.1994

NG-29 Somatrel

Diagnostic measure of the capacity of the pituitary gland to release growth hormone. 08.08.1989

Nifedipine Treatment of interstitial cystitis. 13.06.1991

Nikkomycin Z Treatment of coccidioidomycosis 14.02.2006

nilotinib Tasigna Treatment of gastrointestinal stromal tumors. 20.03.2007

Nimotuzumab Treatment of glioma 17.11.2004

niprisan Hemoxin Treatment of sickle cell disease 15.08.2003

nitazoxanide Cryptaz Treatment for intestinal amebiasis 23.10.2001

Nitisinone Orfadin Treatment of alkaptonuria 19.10.2001

nitric oxide INOmax (r)

Use in combination with a drug delivery device for acute treatment of sickle cell vaso-occlusive crisis (pain crises) 05.09.2008

Nitric oxide Diagnosis of sarcoidosis 16.02.2005

Nitric oxide INOmax

To reduce the risk of chronic lung disease in premature neonates 27.09.2004

Nitric oxideTreatment of acute respiratory distress syndrome in adults. 10.07.1995

NitroprussideTreatment and prevention of cerebral vasospasm following subarachnoid hemorrhage. 21.02.2001

N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide)

Treatment of metastatic melanoma in combination with paclitaxel 18.12.2007

N-Methyl-2-[3-[((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]benzamide Axitinib

Treatment of follicular, medullary and anaplastic thyroid carcinoma and metastatic or locally advanced papillary thyroid cancer. 04.05.2007

Novel Acting Thrombolytic (NAT) Treatment of peripheral arterial occlusion (PAO) 26.01.2001

Nucleic acid aptamer binding to tumor cell nucleolin Treatment of pancreatic cancer 17.08.2004Nucleic acid aptamer binding to tumor cell nucleon Treatment of renal cell carcinoma 28.07.2005

NZ-1002Enzyme replacement therapy in patients with all subtypes of Mucopolysaccharidosis I.

patients with all subtypes of Mucopolysaccharidosis I. 11.04.2001

Obatoclax mesylate Treatment of chronic lymphocytic leukemia 08.10.2004

Obatoclax mesylate Treatment of myelodysplastic syndrome 06.11.2006

Obatoclax mesylate Treatment of myelofibrosis 01.12.2006

oblimersen Genasense Treatment of acute myelocytic leukemia 28.08.2001

oblimersen Genasense Treatment of multiple myeloma 28.08.2001

oblimersen Genasense Treatment of chronic lymphocytic leukemia 28.08.2001

oblimersen Genasense

Treatment of advanced malignant melanoma (Stages II,III, IV). 31.07.2000

ofatumumab Treatment of chronic lymphocytic leukemia 10.03.2009

oglufanide disodium Treatment of ovarian cancer 24.09.2001

OM 401 Drepanol Prophylactic treatment of sickle cell disease. 24.10.1991

omacetaine mepesuccinate Treatment of myelodysplastic syndromes 12.01.2009

Omacetaxine mepesuccinate Treatment of chronic myelogenous leukemia 10.03.2006Omega-3 (n-3) polyunsaturated fatty acid with all double bonds in the cis configuration Prevention of organ graft rejection. 22.11.1995

Omega-3 (n-3) polyunsaturated fatty acids Omacor Treatment of IgA nephropathy. 04.05.2000

Omegaven emulsion Omegaven

Treatment of parenteral nutrition-associated liver disease 27.02.2008

omigapil Treatment of congenital muscular dystrophy. 24.06.2008

oncophage Treatment of glioma 14.04.2009

Oncorad Ov103 Treatment of ovarian cancer. 24.04.1990

oral unfractionated heparin Treatment of sickle cell disease 29.01.2004

Orgotein for injection

Treatment of familial amyotrophic lateral sclerosis associated with a mutation of the gene (on chromosome 21q) for copper, zinc superoxide dismutase. 22.12.1994

Oxaliplatin Treatment of ovarian cancer. 06.10.1992

Oxalobacter formigenes Treatment of primary hyperoxaluria 29.03.2006

Oxandrolone Oxandrin

Treatment of short stature associated with Turner's syndrome. 05.07.1990

Oxandrolone Treatment of constitutional delay of growth and puberty. 05.10.1990

Oxandrolone Oxandrin

Treatment of patients with Duchenne's muscular dystrophy and Becker's muscular dystrophy. 22.04.1997

Oxandrolone Oxandrin

Adjunctive therapy for AIDS patients suffering from HIV-wasting syndrome. 06.09.1991

Oxandrolone Hepandrin

Treatment of moderate/severe acute alcoholic hepatitis in the presence of moderate protein calorie malnutrition. 18.03.1994

Oxymorphone Numorphan H.P.

For relief of severe intractable pain in narcotic-tolerant patients. 19.03.1985

OxypurinolTreatment of hyperuricemia in patients intolerant to allopurinol. 09.11.1998

p1-(uridine 5'-)-p4-(2'-deoxycytidine 5'-) tetraphosphate, tetrasodium salt For the treatment of cystic fibrosis 07.03.2001

P1, P4-Di(uridine 5'-tetraphosphate), tetrasodium salt Treatment of cystic fibrosis. 27.10.1998

paclitaxel Treatment of pancreatic cancer 01.05.2009

Paclitaxel Paxene Treatment of AIDS-related Kaposi's sarcoma. 15.04.1997

paclitaxel aqueous gel OncoGel (tm) Treatment of brain cancer. 23.12.2008

paclitaxel aqueous gel OncoGel(tm) Treatment of esophageal cancer 01.02.2008

paclitaxel, micellar Paclical Treatment of ovarian cancer

Pafuramidine maleateTreatment of human African trypanosomiasis (sleeping sickness) 31.08.2007

Pafuramidine maleate Treatment of malaria 14.05.2007

pafuramidine maleate Treatment of pneumocystis jiroveci pneumonia 17.11.2006

Palifosfamide Treatment of soft tissue sarcomas 05.05.2008

Panobinostat Faridak Treatment of cutaneous T-cell lymphoma 26.09.2007

Papain, trypsin, and chymotrypsin Wobe-Mugos Treatment of multiple myeloma. 21.12.1998

parathyroid hormone Treatment of hypoparathyroidism. 31.08.2007paromomycin sulfate/gentamicin sulfate

Treatment of non-complicated Old World cutaneous leishmaniasis 18.01.2008

Parvovirus B19 (recombinant VP1 and VP2; S.frugiperda cells) vaccine MEDI-491

Prevention of transient aplastic crisis in patients with sickle cell anemia. 07.05.1999

Patul-end

Treatment of patulous eustachian tube.

18.02.1997

Patupilone Treatment of ovarian cancer. 04.10.2005

PEG-glucocerebrosidase Lysodase

For use as chronic enzyme replacement therapy in patients with Gaucher's disease who are deficient in glucocerebrosidase. 09.12.1992

Peginterferon alfa-2a PEGASYS Treatment of chronic myelogenous leukemia. 30.09.1999

Peginterferon alfa-2a PEGASYS Treatment of renal cell carcinoma. 13.07.1998

peginterferon alfa-2b PegIntron

Treatment of malignant melanoma stages IIb through IV. 09.04.2008

PEG-interleukin-2Treatment of primary immunodeficiencies associated with T-cell defects. 01.02.1990

Pegylated arginine deiminase Melanocid Treatment of invasive malignant melanoma. 12.04.1999

Pegylated arginine deiminase Hepacid Treatment of hepatocellular carcinoma. 26.03.1999Pegylated recombinant human megakaryocyte growth and development factor MEGAGEN

For reducing the period of thrombocytopenia in patients undergoing hematopoietic stem cell transplantation. 20.10.1997

Peldesine Treatment of cutaneous T-cell lymphoma. 05.10.1993

Pentamidine isethionate Treatment of Pneumocystis carinii pneumonia. 29.10.1984Pentamidine isethionate (inhalation) Pneumopent

Prevention of Pneumocystis carinii pneumonia in patients at high risk of developing this disease. 05.10.1987

pentetate trisodium diethylenetriaminepenta

Treatment of patients with known or suspected internal contamination with plutonium, americium, or curium. 12.04.2004

pentosan polysulfate sodium Treatment of sickle cell disease. 21.11.2008

Pentostatin Nipent

Treatment of patients with chronic lymphocytic leukemia. 29.01.1991

Pentostatin Nipent Treatment of peripheral T-cell lymphomas. 24.11.1999

Pentostatin Nipent Treatment of cutaneous T-cell lymphoma. 27.03.1998

Peptide 144 TGF beta-1 inhibitor Treatment of systemic sclerosis 27.04.2006

Peptide 144 TGF beta-1-inhibitor Treatment of localized scleroderma 26.04.2006

Peptidomimetic analog of hexarelin Diagnosis of growth hormone deficiency 14.05.2007

Perflubron LiquiVent

Treatment of acute respiratory distress disease (ARDS) in adults 26.04.2001

Perfosfamide Pergamid

For use in the ex-vivo treatment of autologous bone marrow and subsequent reinfusion in patients with acute myelogenous leukemia, also referred to as acute nonlymphocytic leukemia. 04.12.1989

Pergolide Permax Treatment of Tourette's syndrome. 20.11.1997

Phenylacetate

For use as an adjunct to surgery, radiation therapy and chemotherapy for the treatment of patients with primary or recurrent malignant glioma. 06.03.1998

Phenylalanine ammonia-lyase Phenylase Treatment of hyperphenylalaninemia. 08.03.1995

Phenylbutyrate Treatment of acute promyelocytic leukemia. 19.01.2000

phenylephrineTreatment of ileal pouch anal anastomosis related fecal incontinence 14.02.2002

Phosphocysteamine Treatment of cystinosis. 12.09.1988

phosphorothioate antisense olignucleotide against EWS-Fli-1 Treatment of Ewing's sarcoma 22.09.2008

phosphorothioate oligonucleotide Treatment of amyotrophic lateral sclerosis 09.11.2007

Picoplatin Treatment of small cell lung cancer 02.11.2005

Piracetam Nootropil Treatment of myoclonus. 02.10.1987

Piritrexim isethionate

Treatment of infections caused by Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium-intracellulare. 13.06.1988

Plasmid DNA vector expressing cystic fibrosis transmembrane gene Treatment of cystic fibrosis 29.03.2005

plasmin (human) Treatment of acute peripheral arterial occlusion (aPAO) 30.03.2009

Plevitrexed Plevitrexed Treatment of ovarian cancer 14.05.2007

Plevitrexed Plevitrexed Treatment of gastric (stomach) cancer 29.05.2007

Plitidepsin Aplidin Treatment of acute lymphoblastic leukemia 18.06.2004

Plitidepsin Aplidin Treatment of multiple myeloma 30.09.2004

Poloxamer 188

Treatment of vasospasm in subarachnoid hemorrhage patients following surgical repair of a ruptured cerebral aneurysm. 05.08.1997

Poloxamer 188 Flocor Treatment of sickle cell crisis. 27.06.1989

Poloxamer 188 Florcor Treatment of severe burns requiring hospitalization. 22.02.1990

Poloxamer 331 Protox Initial therapy of toxoplasmosis in patients with AIDS. 21.03.1991

Poly I: poly C12U Ampligen Treatment of renal cell carcinoma. 20.05.1991

Poly I: poly C12U Ampligen

Treatment of invasive metastatic melanoma (stage IIb, III, IV). 09.12.1993

Poly I: poly C12U Ampligen Treatment of chronic fatigue syndrome. 09.12.1993

Poly I: poly C12U Ampligen Treatment of AIDS. 19.07.1988

Polyethylene glycol (PEG)-uricase

To control the clinical consequences of hyperuricemia in patients with severe gout in whom conventional therapy is contraindicated or has been ineffective. 21.02.2001

Polyethylene glycol-modified uricase

Treatment of hyperuricemia in patients with gout refractory to conventional therapy or in whom conventional therapy is contraindicated 06.06.2005

Polyethylene glycol-modified uricase Zurase

Prophylaxis of hyperuricemia in cancer patients prone to develop tumor lysis syndrome during chemotherapy. 14.09.1999

Polyethylene glycol-modified uricase Zurase

Treatment of tumor lysis syndrome in cancer patients undergoing chemotherapy. 21.12.1998

Poly-ICLC Hiltonol Treatment of primary brain tumors. 17.03.1997

polyinosinic-polycytidilic acid Poly-ICLC

Treatment of flavivirus infections including those due to West Nile, Japanese encephalitis, dengue, St. Louis encephalitis, yellow fever, Murray valley, and Banzai viruses 03.03.2003

polyinosinic-polycytidilic acid Poly-ICLC As an adjuvant to smallpox vaccination 02.08.2002

polyinosinic-polycytidilic acid (Poly-ICLC) Hiltonol Treatment for orthopox virus infections 19.11.2002

Polymeric oxygen Treatment of sickle cell anemia. 25.03.1992

polyphenon E Treatment of chronic lymphocytic leukemia 17.07.2008

Polyvalent, shed-antigen melanoma vaccine Treatment of stage IIb to stage IV melanoma 09.06.2006Porcine fetal neural dopaminergic cells and/or precursors aseptically NeuroCell-PD

Treatment of Hoehn and Yahr stage 4 and 5 Parkinson's disease. 17.12.1996

Porcine fetal neural dopaminergic cells and/or precursors aseptically NeuroCell-PD

Treatment of Hoehn and Yahr stage 4 and 5 Parkinson's disease. 17.12.1996

Porcine fetal neural gabaergic cells and/or precursors aseptically prepared and coated with anti- NeuroCell-HD Treatment of Huntington's disease. 10.12.1996Porcine fetal neural gabaergic cells and/or precursors aseptically prepared for intracerebral NeuroCell-HD Treatment of Huntington's disease. 10.12.1996Porcine Sertoli cells aseptically prepared for intracerebral co-implantation with fetal neural N-Graft

Treatment of Hoehn and Yahr stage four and five Parkinson's disease. 24.06.1997

Porfimer sodium Photofrin Treatment of cholangiocarcinoma 18.11.2004

Porfimer sodium Photofrin

For the photodynamic therapy of patients with transitional cell carcinoma in situ of the urinary bladder. 15.11.1989

Porfiromycin Promycin Treatment of cervical cancer. 13.03.1997

Porfiromycin Promycin Treatment of head and neck cancer. 19.09.1995

Posaconazole Posoril Treatment of zygomycosis 16.07.2004

Potassium citrate and citric acidFor the dissolution and control of uric acid and cysteine calculi in the urinary tract. 14.02.1986

potassium sodium aluminosilicate For treatment of poisoning by or exposure to cesium. 08.01.2007

PR1 VaccineTreatment of myelodysplastic syndromes requiring therapy 03.09.2004

PR1 Vaccine Treatment of acute myelogenous leukemia 03.09.2004

PR1 Vaccine Treatment of chronic myelogenous leukemia. 03.09.2004

Pr-122 (redox-phenytoin)For the emergency rescue treatment of status epilepticus, grand mal type. 05.07.1990

PR-225 (redox-acyclovir)Treatment of herpes simplex encephalitis in individuals afflicted with AIDS. 29.05.1990

PR-239 (redox penicillin G) Treatment of AIDS associated neurosyphilis. 23.05.1990

Pr-320 (molecusol-carbamazepine)

For the emergency rescue treatment of status epilepticus, grand mal type. 20.07.1990

pralatrexate Treatment of diffuse large B-cell lymphoma 20.10.2008

pralatrexate Treatment of follicular lymphoma 20.10.2008

pralatrexate Treatment of T-cell lymphoma 20.07.2006

pramipexole Mirapex Treatment of Tourette's syndrome in pediatric patients 31.01.2008

Pramiracetam Sulfate

For the management of cognitive dysfunction and enhancement of antidepressant activity associated with electroconvulsive therapy. 04.11.1991

Praziquantel Treatment of neurocysticercosis. 18.04.1988

Prednimustine Sterecyt Treatment of malignant non-Hodgkin's lymphomas. 17.06.1985

Primaquine phosphate

For use in combination with clindamycin hydrochloride in the treatment of Pneumocystis carinii pneumonia associated with AIDS. 23.07.1993

Procarbazine HCl Matulane Treatment of malignant glioma 08.08.2006

Progesterone

Establishment and maintenance of pregnancy in women undergoing in vitro fertilization or embryo transfer procedures. 22.12.1994

Propamidine isethionate 0.1% ophthalmic solution Brolene Treatment of acanthamoeba keratitis. 10.03.1988

propanolol Treatment of proliferating infantile hemangiomas requiring systemic therapy 05.09.2008

Prostaglandin E1 enol ester (AS-013) Circulase

Treatment of Fontaine Stage IV chronic critical limb ischemia. 12.06.1998

Prostaglandin E1 in lipid emulsion Lipo-PGE1

Treatment of ischemic ulceration of the lower limbs due to peripheral arterial disease. 10.09.1996

Protaxel Treatment of ovarian cancer 21.05.2003

Protein C concentrate Protein C Concentrate

For use in the prevention and treatment of purpura fulminans in meningococcemia. 22.04.1993

Protein C concentrate Protein C Concentrate

For replacement therapy in patients with congenital or acquired protein C deficiency for the prevention and treatment of warfarin-induced skin necrosis during oral anticoagulation. 19.06.1992

ProtirelinPrevention of infant respiratory distress syndrome associated with prematurity. 24.08.1993

Protirelin injection Treatment of amyothrophic lateral sclerosis. 10.01.1985

Pulmonary surfactant replacementPrevention and treatment of infant respiratory distress syndrome. 05.12.1988

purified bovine type collagen Treatment of idiopathic pulmonary fibrosis 27.04.2009

Purified extract of Pseudomonas aeruginosa ImmuDyn

Treatment of immune thrombocytopenia purpura where it is required to increase platelet counts. 22.09.1997

Purified type II collagen Colloral Treatment of juvenile rheumatoid arthritis. 09.02.1995

Pyruvate Treatment of interstitial lung disease. 21.02.2001

Quinacrine hydrochlorideFor prevention of recurrence of pneumothorax in patients at high risk of recurrence. 17.10.1984

quinine sulfate Treatment of malaria excluding Plasmodium faliparum 02.12.2008

R-(-)-gossypol Treatment of chronic lymphocytic leukemia. 24.10.2006R-4-amino-3-(4-chlorophenyl)butanoic acid

Treatment of the behavorial abnormalities associated with fragile X syndrome. 28.11.2008

rAAV2-CB-hRPE65 Treatment of type II Leber's Congential Amaurosis 11.02.2005

Rabbit anti-human thymocyte globulin (rATG) Thymoglobulin

Induction treatment to prevent rejection and to minimize maintenance immunosupression in pediatric liver transplant recipients 26.09.2006

ranprinase Onconase Treatment of malignant mesothelioma 25.01.2007

Rapamycin Treatment of tuberous sclerosis complex 20.03.2007

Rapamycin (mTOR) inhibitor Treatment of bone sarcoma 09.08.2005

raxibacumab Abthrax Treatment of anthrax 12.11.2003

recombinant adeno-associated virus alpha 1-antitrypsin vector rAAV-AAT Treatment of alpha1-antitrypsin deficiency 27.01.2003

Recombinant anti-CD22 immunotoxin

Treatment of CD22-positive chronic lymphocytic leukemia 15.11.2007

Recombinant anti-CD22 immunotoxin Treatment of hairy cell leukemia 15.11.2007

Recombinant anti-CD40 monoclonal antibody Treatment of chronic lymphocytic leukemia 12.08.2005

Recombinant anti-CD-40 monoclonal antibody Treatment of multiple myeloma 25.01.2006Recombinant bactericidal/permeability-increasing protein Neuprex Treatment of severe meningococcal disease. 22.06.1998

recombinant chimeric monoclonal antibody to anthrax Anthim Treatment of exposure to B. anthracis spores 09.06.2006Recombinant coagulation factor VIIa Novoseven Treatment of diffuse alveolar hemorrhage 26.04.2006

Recombinant deriative of C3 transferase Cethrin Treatment of acute spinal cord injury 18.11.2005Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs

Treatment of thrombotic thrombocytopenic purpura including its congential, acquired idiopathic, and secondary forms. 29.07.2008

Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs

Prevention of thrombotic thrombocytopenic purpura including its congential, acquired idiopathic and secondary forms. 29.07.2008

Recombinant Epstein-Barr virus gp350 glycoprotein vaccine

Prevention of post-transplantation lymphoproliferative disorders in pediatric recipients of solid-organ transplantation 18.08.2005

Recombinant fully human monoclonal antibody to anthrax protective antigen Valortim Treatment of anthrax infection 16.02.2006recombinant fusion protein with a truncated form of the cytotoxic protein Pseudomonas exotoxin Proxinium

Treatment of Ep-CAM-positive squamous cell carcinoma of the head and neck

28.01.2005Recombinant glycine2-human glucagon-like peptide-2 Treatment of short bowel syndrome. 29.06.2000Recombinant human alpha 1-antitrypsin Prevention of bronchopulmonary dysplasia 28.04.2005

recombinant human alpha 1-antitrypsin (rAAT) Treatment of cystic fibrosis 20.11.2001recombinant human alpha-1 antitrypsin Treatment of cystic fibrosis. 06.03.1998

recombinant human alpha-1 antitrypsin (rAAT)

To delay progression of chronic obstructive pulmonary disease resulting from AAT deficiency-mediated emphysema and bronchiectasis 28.08.2001

Recombinant Human Alpha-Fetoprotein (rhAFP) Treatment of myasthenia gravis 22.02.2001

Recombinant human alpha-mannosidase Treatment of alpha-mannosidosis 02.02.2006Recombinant human anti-GDF-8 (growth and differentiation factor-8) antibody

Treatment of Duchenne and Becker muscular dystrophies 16.02.2005

Recombinant human antithrombin III

Treatment of antithrombin III dependent heparin resistance requiring anticoagulation. 06.04.2000

recombinant human arylsulphatase A Treatment of metachromatic leukodystrophy (MLD). 11.04.2008

Recombinant human C1 inhibitor Treatment of capillary leakage syndrome 09.06.2006

Recombinant human C1 inhibitorPrevention and/or treatment of delayed graft function after solid organ transplantation 09.06.2006

Recombinant human C1-esterase inhibitor

Treatment of (acute attacks of) angioedema caused by hereditary or acquired C1-esterase inhibitor deficiency. 23.02.1999

Recombinant human C1-esterase inhibitor

Prophylactic treatment of angioedema caused by hereditary or acquired C1-esterase inhibitor deficiency. 23.02.1999

Recombinant human CD4 immunoglobulin G Treatment of AIDS resulting from infection with HIV-1. 30.08.1990

Recombinant human Clara Cell 10kDa protein

Prevention of neonatal bronchopulmonary dysplasia in premature neonates with respiratory distress syndrome. 13.07.1998

recombinant human coagulation factor IX fusion protein

For the control and prevention of hemorrhagic episodes in patients with hemophilia B (congential factor IX deficiency or Christmas disease). 30.10.2008

Recombinant human endostatin protein Treatment of neuroendocrine tumors 13.08.2001

recombinant human endostatin protein Treatment of metastatic melanoma 21.02.2002

Recombinant human fibrinogen Treatment of bleeding in patients deficient in fibrinogen 04.10.2007

recombinant human fibroblast growth factor-20 Treatment of radiation induced oral mucositis 29.01.2004

Recombinant human gelsolinTreatment of acute and chronic respiratory symptoms of bronchiectasis. 06.03.1995

Recombinant human gelsolinTreatment of the respiratory symptoms of cystic fibrosis. 12.01.1994

Recombinant human granulocyte colony stimulating factor Prevention of implantation failure 24.07.2006

Recombinant human highly phosphorylated acid alpha-glucosidase TBD

For enzyme replacement therapy in patients with all subtypes of glycogen storage disease type II (GSDII, Pompe Disease) 20.09.2000

recombinant human histone H1.3; recombinant human N-bis-met-histone H1.3 Oncohist (r) Treatment of acute myeloid leukemia 20.10.2008

Recombinant human insulin-like growth factor 1 IGF-1 Treatment of growth hormone receptor deficiency. 07.06.1995

Recombinant human insulin-like growth factor 1 IGF-1

Treatment of antibody-mediated growth hormone resistance in patients with isolated growth hormone deficiency Ia. 07.06.1995

Recombinant human insulin-like growth factor-I PV802

Treatment of short-bowel syndrome as a result of resection of the small bowel or as a result of congenital dysfunction of the intestines. 16.02.2000

Recombinant human insulin-like growth factor-I Treatment of post-poliomyelitis syndrome. 13.10.1995Recombinant human insulin-like growth factor-I/insulin-like growth factor binding protein-3 Treatment of major burns that require hospitalization. 15.06.1999

Recombinant human interleukin-12 Treatment of renal cell carcinoma. 20.10.1997

Recombinant Human Interleukin-21 (rIL-21)

Treatment of stage II (T4), III or IV malignant melanoma. 04.10.2005

Recombinant human keratinocyte growth factor

Reducing the incidence and severity of radiation-induced xerostomia. 20.12.1999

Recombinant human lysosomal acid lipase or cholesteryl ester hydrolase Cholestrase

Treatment of lipase deficiencies, including Wolman Disease and cholesteryl ester storage disease 14.07.2005

Recombinant human microplasmin Treatment of peripheral arterial occlusion 23.01.2006

recombinant human minibody against complement component MUBODINA

Treatment of primary membranoproliferative glomerulonephritis 04.02.2009

recombinant human minibody against complement component C5 fused with RGD-motif

Prevention of ischemmia/reperfusion injury associated with solid organ transplantation. 04.02.2009

recombinant human monoclonal antibody to hsp90 Mycograb Treatment of invasive candidiasis 16.09.2002Recombinant human nerve growth factor Treatment of HIV-associated sensory neuropathy. 16.04.1999recombinant human neutrophil inhibitor (hNE) Treatment of cystic fibrosis 09.12.2003

Recombinant human platelet derived growth factor BB Treatment of osteonecrosis of the jaws 01.02.2007

recombinant human porphobilinogen deaminase Porphozyme Treatment of acute intermittent porphyria attacks 09.09.2002recombinant human porphobilinogen deaminase, erythropoetic form

Treatment of acute intermittent porphyria preventing attacks 11.07.2002

recombinant human proinsulin Treatment of retinitis pigmentosa 10.12.2008

Recombinant human relaxin Treatment of progressive systemic sclerosis. 03.11.1995

recombinant human rod-derived cone viability factor Treatment of retinitis pigmentosa 07.01.2008Recombinant human thrombopoietin

For use in accelerating platelet recovery in patients undergoing hematopoietic stem cell transplantation. 29.09.1997

recombinant human type I pancreatic elastase

Prevention of arteriovenous fistula maturation and arteriovenous graft failure in patients with end stage renal disease who are receiving hemodialysis or preparing for hemodialysis 03.04.2009

recombinant human type VII collagen

Treatment of hereditary dystrophic epidermolysis bullosa (DEB) 18.06.2008

Recombinant humanized MAb 5c8 Prevention of rejection of solid organ transplants. 22.03.1999

Recombinant humanized MAb 5c8Prevention of rejection of pancreatic islet cell transplants. 22.03.1999

Recombinant humanized MAb 5c8Prevention and treatment of Factor VIII/Factor IX inhibitors in patients with hemophilia A or B. 14.10.1998

Recombinant humanized monclonal antibody 5c8 Treatment of immune thrombocytopenic purpura. 03.02.1998

Recombinant humanized monoclonal antibody 5c8 Treatment of systemic lupus erythematosus. 18.02.1998

Recombinant methionyl brain-derived neurotrophic factor Treatment of amyotrophic lateral sclerosis. 28.11.1994

recombinant ovine interferon tau Tauferon Treatment of pediatric multiple sclerosis 25.01.2005Recombinant Porcine Factor VIII, B-domain Deleted

patients with inhibitor antibodies to human coagulation factor VIII 16.03.2004

Recombinant P-Selectin glycoprotein ligand

Prevention of delayed graft function in renal transplant patients 29.03.2006

Recombinant P-selectin glycoprotein ligand-

Prevention of ischemia reperfusion injury in all solid organ transplants 26.07.2007

Recombinant retroviral vector - glucocerebrosidase

For use as enzyme replacement therapy for patients with types I, II, or III Gaucher disease. 15.11.1993

Recombinant secretory leucocyte protease inhibitor Treatment of cystic fibrosis. 29.03.1991

Recombinant secretory leucocyte protease inhibitor Treatment of congenital alpha-1 antitrypsin deficiency. 29.03.1991

Recombinant soluble human CD4 Receptin Treatment of acquired immunodeficiency syndrome. 20.11.1989

Recombinant soluble human CD4 (rCD4) Treatment of AIDS in patients infected with HIV virus. 23.03.1989

Recombinant T-cell receptor ligand

Treatment of multiple sclerosis patients who are both HLA-DR2 positive and autoreactive to myelin oligodendrocyte glycoprotein residues 35-55 02.05.2003

Recombinant truncated SPINT2 protease inhibitor Treatment of cystic fibrosis 24.06.2005

Recombinant urate oxidase Prophylaxis of chemotherapy-induced hyperuricemia. 11.10.2000

Reduced L-glutathione Cachexon Treatment of AIDS-associated cachexia. 14.02.1994

Remacemide Ecovia Treatment of Huntington's disease. 06.03.2000

ReparixinPrevention of delayed graft function in solid organ transplant 27.01.2003

repository corticotropin or adrenocorticotropic hormone H.P. Acthar Gel Treatment of infantile spasms 21.05.2003

resiniferatoxin Treatment of intractable pain at end-stage disease 13.05.2003

reslizumab Treatment of children with eosinophilic esophagitis 19.12.2007

Respiratory Syncytial Virus Immune Globulin (human) Hypermune RSV

Treatment of respiratory syncytial virus lower respiratory tract infections in hospitalized infants and young children. 27.09.1990

retaspimycin Treatment for gastrointestinal stromal tumor 31.08.2007

retaspimycin hydrochloride Treatment of melanoma stages IIb through IV. 24.06.2008

R-etodolac Treatment of chronic lymphocytic leukemia 09.12.2002

retroviral gamma-c cDNA containing vector

Treatment of X linked severe combined immune deficiency disease 29.04.2002

Retroviral vector, R-GC and GC gene 1750 Treatment of Gaucher disease. 06.05.1997

Reviparin sodium Clivarine

Treatment of deep vein thrombosis which may lead to pulmonary embolism in pediatric patients 18.06.2001

Reviparin sodium Clivarine

Long-term treatment of acute deep vein trombosis with or without pulmonary embolism in pregnant patients 18.06.2001

RGG0853, E1A lipid complex Treatment of ovarian cancer. 15.09.1995

rhIGF-I/rhIGFBP-3 SomatoKine

Treatment of extreme insulin resistance syndromes (type A, Rabson-Mendenhall syndrome, Leprechaunism, Type B syndrome) 09.12.2003

rh-microplasmin Adjunct to surgery in cases of pediatric vitrectomy 16.03.2004

Ribavirin Virazole Treatment of hemorrhagic fever with renal syndrome. 12.04.1991

Ricin (blocked) conjugated murine mca (anti-b4)

For the ex-vivo purging of leukemic cells from the bone marrow of non-T cell acute lymphocytic leukemia patients who are in complete remission. 24.01.1991

Ricin (blocked) conjugated murine MCA (anti-B4) Treatment of B-cell leukemia and B-cell lymphoma. 17.11.1988

Ricin (blocked) conjugated murine MCA (anti-my9)

Treatment of myeloid leukemia, including AML, and blast crisis of CML. 03.08.1989

Ricin (blocked) conjugated murine MCA (anti-my9)

For use in the ex-vivo treatment of autologous bone marrow and subsequent reinfusion in patients with acute myelogenous leukemia. 01.02.1990

Ricin (blocked) conjugated murine MCA (n901) Treatment of small cell lung cancer 25.01.1991

Ricin (blocked) conjugated murine monoclonal antibody (CD6)

Treatment of cutaneous T-cell lymphomas, acute T-cell leukemia-lymphoma, and related mature T-cell malignancies. 06.09.1994

RifabutinTreatment of disseminated Mycobacterium avium complex disease. 18.12.1989

Rifalazil Treatment of pulmonary tuberculosis. 13.04.1999

Rifapentine Priftin

Prophylactic treatment of Mycobacterium avium complex in patients with AIDS and a CD4+ count less than or equal to 75/mm3. 12.03.1996

Rifapentine Priftin

Treatment of Mycobacterium avium complex in patients with AIDS. 09.06.1995

Rifaximin Normix Treatment of hepatic encephalopathy 10.02.1998

RII retinamide Treatment of myelodysplastic syndromes. 06.05.1993

Riluzole Rilutek Treatment of Huntington's disease. 15.10.1996

risedronate sodium Actonel Treatment of patients with osteogenesis imperfecta. 18.12.2006

rituximab Rituxan

Treatment of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (Wegener's Granulomatosis, Microscopic Polyangiitis, and Churg-Strauss Syndrome) 14.02.2006

rituximab Rituxan Treatment of immune thrombocytopenic purpura 12.03.2002

rituximab Rituxan Treatment of chronic lymphocytic leukemia 29.01.2004RNA, ((2',3'-dideoxy-2',3'-imino-2',3'-seco)[dimethylamino)phosphinylid Treatment of Duchenne Muscular Dystrophy. 23.10.2007

rofecoxib Vioxx Treatment of juvenile rheumatoid arthritis 16.03.2004

romidepsin Treatment of non-Hodgkin T-cell lymphomas 30.09.2004

Roquinimex Linomide

To prolong time to relapse in leukemia patients who have undergone autologous bone marrow transplantation. 01.07.1993

Rose Bengal Disodium Treatment of metastatic melanoma 20.12.2006

rSP-C lung surfactant Venticute Treatment of adult respiratory distress syndrome. 03.04.2000

rSP-C surfactant Venticute

For use in patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygen impairment 18.09.2006

rubitecan

Treatment of pediatric patients infected with human immunodeficiency virus and acquired immunodeficiency syndrome 17.07.2002

S(-)-3-[3-amino-phthalimido]-glutaramide Treatment of multiple myeloma 14.03.2002

S-adenosylmethionine Treatment of AIDS-myelopathy. 30.04.1998

salirasib Treatment of panreatic cancer. 18.12.2006

sarsasapogenin Treatment of amyotrophic lateral sclerosis (ALS) 18.06.2004

SB-408075 For pancreatic cancer 07.12.2000

SC-1 monoclonal antibodyTreatment of patients with CD55 (sc-1) positive gastric tumors 12.11.2003

SCH 58500 Treatment of primary ovarian cancer. 12.04.1999

SDF-1 (108) Lysine Dlmer Treatment of osteogenic sarcoma 07.07.2005

Secalciferol Osteo-D Treatment of familial hypophosphatemic rickets. 26.07.1993Secretory leukocyte protease inhibitor Treatment of bronchopulmonary dysplasia. 30.06.1992

Seneca Valley virus Treatment of neuroendocrine tumors Treatment of neuroendocrine tumors 22.08.2008

Sermorelin acetate Geref

ovulation in women with anovulatory or oligo-ovulatory infertility who fail to ovulate in response to adequate 13.02.1990

Sermorelin acetate Geref Treatment of AIDS-associated catabolism/weight loss. 05.12.1991Serratia marcescens extract (polyribosomes) Imuvert Treatment of primary brain malignancies. 07.09.1988

SGN-30 (anti-CD30 antibody) Treatment of CD30 positive T-cell lymphomas 18.02.2004

SGN-30 (anti-CD30 mAb) Treatment of Hodgkin's disease 18.07.2003

SGN-35 (cAC10-vcMMAE(4)) Treatment of anaplastic large cell lymphoma 23.10.2008

SGN-40 (anti-CD40 antibody) Treatment of multiple myeloma. 13.08.2004

Short chain fatty acid enema Colomed Treatment of chronic radiation proctitis. 19.08.1997

Short chain fatty acid solution Colomed

Treatment of the active phase of ulcerative colitis with involvement restricted to the left side of the colon. 29.05.1990

Silver sulfadiazine and cerium nitrate Flammacerium Prevention of mortality in severely burned patients. 17.11.1999

siplizumab Treatment of T-cell lymphomas 15.07.2003

Sitaxsentan Sodium

For the treatment of pulmonary arterial hypertension in the absence of chronic obstructive pulmonary disease or congestive heart failure. 02.11.2004

SK&F 110679

For the long term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion. 23.05.1990

sodium 2, 2 dimethylbutyrate Treatment of sickle cell disease. 25.07.2008sodium 4-{ [9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido [5,4-d] [2] benzazepin-2-yl]-2- Treatment of ovarian cancer 03.04.2009

Sodium aluminosilicate Treatment of chronic hepatic encephalopathy 04.03.2005

Sodium ascorbate and menadione sodium bisulfite Apatone

Treatment of metastatic or locally advanced inoperable transitional cell carcinoma of the urothelium (stage III and IV bladder cancer) 31.07.2007

Sodium dichloroacetateTreatment of homozygous familial hypercholesterolemia. 11.06.1990

Sodium dichloroacetate Treatment of congenital lactic acidosis. 11.06.1990

Sodium dichloroacetate Treatment of congenital lactic acidosis. 31.12.1997

Sodium dichloroacetateTreatment of lactic acidosis in patients with severe malaria. 10.11.1994

sodium dichloroacetateUse as an antidote in the management of systemic monochloroacetic acid poisoning 03.07.2003

Sodium dichloroacetate Ceresine Treatment of severe head injury. 14.06.1999Sodium Monomercaptoundecahydro-closo-dodecaborate Borocell

For use in boron neutron capture therapy (BNCT) in the treatment of glioblastoma multiforme. 15.04.1992

Sodium monomercaptoundecahydro-closo-dodecaborate

For use in conjunction with a thermal or epithermal neutron beam in boron nuclear capture therapy of glioblastoma multiforme. 18.12.1984

Sodium nitrite Treatment of vaso-occlusive crisis associated with sickle cell disease 02.04.2007

Sodium nitrite Treatment of cyanide poisoning 18.04.2007

Sodium nitritePrevention of vasospasm associated with subarachnoid hemorrhage 17.01.2007

sodium nitrite Treatment of pulmonary arterial hypertension 08.07.2008

Sodium nitrite and sodium thiosulfate Cyanide Antidote Kit Treatment of known or suspected cyanide poisoning 09.04.2008

Sodium nitrite/sodium thiosulfate Cyanide Antidote PackaTreatment of cyanide poisoning 23.03.2007

Sodium phenylacetate/sodium benzoate 10%/10% Injection Ammonul Treatment of grade III and IV hepatic encephalopathy 03.06.2005

Sodium phenylbutyrate Treatment of spinal muscular atrophy 20.03.2007

Sodium phenylbutyrate Buphenyl Treatment of spinal muscular atrophy 25.01.2007

Sodium phenylbutyrate

For use as an adjuct to surgery, radiation therapy and chemotherapy for the treatment of patients with primary or recurrent malignant glioma. 24.04.1998

sodium phenylbutyrate

Treatment for sickling disorders, which include S-S hemoglobinopathy, S-C hemoglobinopathy, and S-thalassemia hemoglobinopathy. 02.07.1992

Sodium pyruvate Treatment of cystic fibrosis 31.03.2003

Sodium stibogluconate Treatment of cutaneous leishmaniasis 16.06.2006

Sodium thiosulfatePrevention of platinum-induced ototoxicity in pediatric patients 17.03.2004

Sodium thiosulfate and sodium nitrite Treatment of cyanide poisoning 18.12.2006

Sodium thiosulfate, sodium nitrite, amyl nitrite Cyanide Antidote PackaTreatment of cyanide poisoning 16.06.2006

Solasonine and solamargine Coramsine Treatment of renal cell carcinoma 02.11.2005

Solasonine and solamargine Coramsine

Treaatment of high risk stage II, stage III and stage IV melanoma 06.02.2006

Soluble complement receptor type 1

Prevention of post-cardiopulmonary bypass syndrome in children undergoing cardiopulmonary bypass. 06.03.2000

Soluble recombinant human complement receptor type 1

Prevention or reduction of adult respiratory distress syndrome. 21.11.1994

Solvent/detergent treated non-blood group specific human coagulation active plasma UNIPLAS Treatment of thrombotic thrombocytopenic purpura 12.12.2005

Somatostatin Zecnil

Adjunct to the non-operative management of secreting cutaneous fistulas of the stomach, duodenum, small intestine (jejunum and ileum), or pancreas. 20.06.1988

Somatostatin Treatment of bleeding esophageal varices. 22.12.1994

Somatrem for injection Protropin

Treatment of short stature associated with Turner's syndrome. 09.12.1985

Somatropin Humatrope

Treatment of short stature in pediatric patients with short stature homeobox-containing gene (SHOX) deficiency 15.12.2005

Somatropin Norditropin

Treatment of short stature associated with Turner's syndrome. 05.11.1987

Somatropin Norditropin

Adjunct for the induction of ovulation in women with infertility due to hypogonadotropic hypogonadism or bilateral tubal occlusion or unexplained infertility, who 01.09.1987

Somatropin Biotropin Treatment of cachexia associated with AIDS. 12.02.1993

Somatropin Serostim

Treatment of patients with HIV-associated adipose redistribution syndrome 16.03.2004

Somatropin (rDNA) Saizen

For the enhancement of nitrogen retention in hospitalized patients suffering from severe burns. 03.05.1989

Somatropin (r-DNA) for injection Serostim

Treatment of children with AIDS-associated failure-to-thrive including AIDS-associated wasting. 26.03.1996

Sorafenib Nexavar Treatment of stage IIB through stage IV melanoma 29.09.2006

Sorivudine BRAVAVIR

Treatment of herpes zoster (shingles) in immunocompromised patients. 09.11.1995

Sotalol HCl Betapace

Prevention of life threatening ventricular tachyarrhythmias. 23.09.1988

spherical carbon adsorbent Treatment of chronic pouchitis 19.12.2007

Spiramycin Rovamycine

For symptomatic relief and parasitic cure of chronic cryptosporidiosis in patients with immunodeficiency. 17.10.1984

squalamine lactateTreatment of ovarian cancer refractory or resistant to standard chemotherapy Treatment of ovarian cancer 11.05.2001

SS1(dsFv)-PE38 Treatment of epithelial ovarian cancer 11.02.2002

SS1(dsFv)-PE38 Treatment of malignant mesothelioma 11.02.2002

ST1-RTA immunotoxin (SR 44163)

Treatment of patients with B-chronic lymphocytic leukemia. 12.08.1987

ST1-RTA immunotoxin (SR 44163)

Prevention of acute graft versus host disease in allogenic bone marrow transplantation. 12.08.1987

Staphylococcus aureus Immune Globulin (Human) Altastaph

Prophylaxis against Staphylococcus aureus infections in low birth weight neonates 29.01.2004

Stem and progenitor cells derived from ex vivo expanded allogeneic umbilical cord blood StemEx

For use as hematopoietic support in patients with relasped or refractory hematologic malignancies who are receiving high-dose therapy 04.03.2005

Sterile talc Steritalc Treatment of malignant pleural effusion. 08.12.1997

Sterile talc Steritalc Treatment of pneumothorax. 08.12.1997

stiripentol diacomit(r) Treatment of Dravet syndrome 30.10.2008

SU101 Treatment of ovarian cancer. 12.03.1996

SU101 Treatment of malignant glioma. 25.05.1995

Succimer Chemet Treatment of mercury intoxication. 22.03.1991

Succimer Chemet

Prevention of cystine kidney stone formation in patients with homozygous cystinuria who are prone to stone development. 05.11.1990

SucralfateTreatment of oral mucositis and stomatitis following radiation therapy for head and neck cancer. 15.07.1993

Sucralfate suspensionTreatment of oral complications of chemotherapy in bone marrow transplant patients. 12.03.1990

Sucralfate suspensionTreatment of oral ulcerations and dysphagia in patients with epidermolysis bullosa. 04.03.1991

sulfamidase For treatment of Sanfilippo Syndrome. 22.05.2008

Sulfapyridine Treatment of dermatitis herpetiformis. 10.09.1990

Superoxide dismutase (human)

For protection of donor organ tissue from damage or injury mediated by oxygen-derived free radicals that are generated during the necessary periods of ischemia (hypoxia, anoxia), and especially reperfusion, 06.03.1985

Superoxide dismutase (recombinant human) Oxsodrol Prevention of reperfusion injury to donor organ tissue. 17.05.1988

Suramin Metaret Treatment of hormone-refractory prostate cancer. 06.05.1997

Surfactant (human) (amniotic fluid derived) Human Surf

Prevention and treatment of neonatal respiratory distress syndrome. 25.03.1987

Synsorb Pk Treatment of verocytotoxogenic E. coli infections. 17.07.1995

Synthetic Human Parathyroid Hormone 1-34 Treatment of hypoparathyroidism 26.01.2001

Synthetic human secretin

For use in conjunction with diagnostic procedures (excluding ERCP) for pancreatic disorders to increase pancreatic fluid secretion 18.09.2006

Synthetic human secretinFor use in the diagnosis of gastrinoma associated with Zollinger-Ellison syndrome. 16.06.1999

Synthetic human secretin

For use in conjunction with diagnostic procedures for pancreatic disorders to increase pancreatic fluid secretion. 07.03.2000

Synthetic human secretinFor use in obtaining desquamated pancreatic cells for cytopathologic examination in pancreatic carcinoma. 16.06.1999

Synthetic human secretinFor use in the evaluation of exocrine pancreas function.

16.06.1999

Synthetic porcine secretinFor use in obtaining desquamated pancreatic cells for cytopathologic examination in pancreatic carcinoma. 18.06.1999

T4 endonuclease V, liposome encapsulated

To prevent cutaneous neoplasms and other skin abnormalities in xeroderma pigmentosum. 27.06.1989

Tacrolimus Prograf Prophylaxis of graft-versus-host-disease. 06.04.1998

Tadalafil Cialis Treatment of pulmonary arterial hypertension 18.12.2006

TAK-603 Treatment of Crohn's disease. 13.05.1998

Talactoferrin alfa Treatment of non-small cell lung cancer 08.08.2007

talactoferrin alfa Treatment of renal cell carcinoma 29.09.2006

talactoferrin alfa For the treatment of graft versus host disease 20.08.2003

talactoferrin alfa For the prevention of graft-versus-host disease 20.08.2003

talampanel Treatment of glioma 17.02.2009

talampanel Treatment of amyotrophic lateral sclerosis 24.03.2008

Tamibarotene Treatment of acute promyelocytic leukemia (APL). 11.10.2007

Tanespimycin Treatment of multiple myeloma 09.09.2004T-cell depleted stem cell enriched cellular product from peripheal blood stem cells Treatment of chronic granulomatous disease 01.11.2001

TD-K6a.513a.12 ReveKer Treatment of pachyonychia congenita 15.06.2006Technetium Tc 99m pterotetramide For the identification of ovarian carcinomas. 16.02.2000

Technetium Tc99m anti-melanoma murine monoclonal antibody Oncotrac Melanoma Im

For use in detecting, by imaging, metastases of malignant melanoma. 02.06.1987

Technetium Tc99m murine monoclonal antibody (IgG2a) to B cell LymphoScan

Diagnostic imaging in the evaluation of the extent of disease in patients with histologically confirmed diagnosis of non-Hodgkin's B-cell lymphoma, acute B-cell lymphoblastic leukemia (in children and adults), and 07.04.1992

Technetium Tc99m murine monoclonal antibody to hCG Immuraid, hCG-Tc-99m

Detection of hCG producing tumors such as germ cell and trophoblastic cell tumors. 07.08.1989

Technetium Tc99m murine monoclonal antibody to human AFP-Scan

Detection of alpha-fetoprotein producing germ cell tumors. 01.08.1989

Technetium Tc99m murine monoclonal antibody to human alpha-fetoprotein Immuraid, AFP-Scan

Detection of hepatocellular carcinoma and hepatoblastoma. 01.08.1989

Technetium Tc99m rh-Annexin V Apomate

Diagnosis or assessment of rejection status in heart, heart-lung, single lung, or bilateral lung transplants. 03.11.2000

Tegafur/gimeracil/oteracil Treatment of gastric cancer 20.07.2006

temocillin sodium Negaban

Treatment of pulmonary infections caused by Burkholderia cepacia 21.04.2004

Temoporfin Foscan

Palliative treatment of recurrent, refractory or second primary squamous cell carcinomas of the head and neck in patients considered to be incurable with surgery or radiotherapy. 28.10.1999

Temozolomide Temodal Treatment of newly diagnosed high grade glioma 18.10.2004

Temozolomide Temodal Treatment of advanced metastatic melanoma. 14.10.1998

tenofovir disoproxil fumarate Viread(r) Treatment of pediatric HIV infection. 17.03.2009

terguride Treatment of pulmonary arterial hypertension 01.05.2008

Teriparatide Parathar Treatment of idiopathic osteoporosis. 28.10.1999

Terlipressin Glypressin Treatment of bleeding esophageal varices. 06.03.1986

Terlipressin (INN) Treatment of Hepatorenal Syndrome

Fast Track granted by CDER. A rolling NDA submission is planned by the sponsor. 29.10.2004

tesetaxelTreatment of stages IIB, IIC, III, and stage IV melanoma 21.11.2008

tesetaxel Treatment of gastric cancer 22.12.2008

Testosterone TheraDerm Testosteron

For use as physiologic testosterone replacement in androgen deficient HIV+ patients with an associated weight loss. 22.09.1997

Testosterone propionate ointment 2% Treatment of vulvar dystrophies. 31.07.1991

Testosterone sublingualTreatment of constitutional delay of growth and puberty in boys. 16.01.1991

Tetrabenazine Treatment of moderate/severe tardive dyskinesia. 12.05.1998

Tetraiodothyroacetic acidSuppression of thyroid stimulating hormone in patients with well-differentiated cancer of the thyroid gland. 01.05.2000

TezacitabineTreatment of adenocarcinoma of the esophagus and stomach 27.01.2003

TGF(beta)2-specific phosphorothioate antisense oligodeoxynucleotide Oncomun Treatment of malignant glioma 05.06.2002

TGp1PTH1-34 Treatment of solitary (unicameral) bone cysts. 01.02.2007

Thalidomide Thalomid Treatment of myelodysplastic syndrome 27.09.2004

ThalidomideTreatment and prevention of recurrent aphthous ulcers in severely, terminally immunocompromised patients. 15.05.1995

Thalidomide Synovir Treatment of HIV-associated wasting syndrome. 11.03.1996

Thalidomide Thalomid Treatment of Crohn's disease. 06.04.1999

ThalidomidePrevention of graft versus host disease in patients receiving bone marrow transplantation. 19.09.1988

ThalidomideTreatment of graft versus host disease in patients receiving bone marrow transplantation. 19.09.1988

ThalidomideTreatment and maintenance of reactional lepromatous leprosy. 15.11.1988

Thalidomide

Treatment of the clinical manifestations of mycobacterial infection caused by Mycobacterium tuberculosis and non-tuberculous mycobacteria. 12.01.1993

Thalidomide Prevention of graft versus host disease. 05.03.1990

Thalidomide Treatment of graft versus host disease. 05.03.1990

Thalidomide Treatment of primary brain malignancies. 27.02.1998

ThalidomideTreatment of severe recurrent aphthous stomatitis in severely, terminally immunocompromised patients. 01.05.1995

Thalidomide Treatment of Kaposi's sarcoma. 29.07.1998

Thiotepa Tepadina

Conditioning treatment prior to hematopoietic stem cell transplantation 02.04.2007

Thymalfasin Zadaxin

Treatment of stage IIb through Stage IV malignant melanoma 13.03.2006

Thymalfasin Zadaxin Treatment of chronic active hepatitis B. 03.05.1991

Thymalfasin Zadaxin Treatment of DiGeorge anomaly with immune defects. 08.01.1998

Thymalfasin Zadaxin Treatment of hepatocellular carcinoma. 06.03.2000

Thymosin beta 4 Treatment of epidermolysis bullosa 28.05.2004

Thymoxamine HCl

Reversal of phenylephrine-induced mydriasis in patients who have narrow anterior angles and are at risk of developing an acute attack of angle-closure glaucoma following mydriasis. 16.11.1987

Tiapride Treatment of Tourette's syndrome. 21.04.1998

Tiazofurin (2-Beta-D-ribofuranosyl-4-thiazolecarboxamide) Chronic myelogenous leukemia (CML) 27.12.2000

Tilarginine acetate Treatment of cardiogenic shock 11.04.2005

tin ethyl etiopurpurinPrevention of access graft disease in hemodialysis patients 04.11.2003

Tiotropium bromide Spiriva

To improve pulmonary function in conjunction with standard therapy in the management of patients with cystic fibrosis 08.01.2008

Tipifarnib Zarnestra Treatment of acute myeloid leukemia 06.07.2004

tirapazamine Treatment of head and neck cancer 23.10.2002

Tiratricol Triacana

For use in combination with levo-thyroxine to suppress thyroid stimulating hormone in patients with well-differentiated thyroid cancer who are intolerant to adequate doses of levo-thyroxine alone. 13.08.1991

Tissue repair cells obtained from autologous bone marrow expanded ex vivo with a cell Treatment of osteonecrosis 13.03.2006Tissue repair cells obtained from autologous bone marrow expanded ex vivo with a cell Treatment of dilated cardiomyopathy 25.01.2007

Titanium dioxide and bisoctrizole

For the secondary prevention (prevention of lesional induction) of disorders with UV-A and visible light-induced photosensitivity, specifically Actinic prurigo, Hydroa vacciniforme, Solar urticara (SU), Chronic 25.05.2005

Tizanidine HCl Zanaflex

Treatment of spasticity associated with multiple sclerosis and spinal cord injury.

For the acute and intermittent management of increased muscle tone associated with spasticity. 31.01.1994

Tobramycin Tobi

Treatment of bronchiectasis patients infected with Pseudomonas aeruginosa. 18.06.1999

tobramycin liposomal for inhalation Fluidosomes

Treatment of chronic pulmonary infection due to P. aeruginosa in cystic fibrosis patients 14.04.2009

Tocophersolan oral solution (vitamin E-tpgs)

Treatment of vitamin E deficiency resulting from malabsorption due to prolonged cholestatic hepatobiliary disease. 15.04.1988

toralizumab Treatment of immune thrombocytopenic purpura 14.03.2002

Toremifene Treatment of desmoid tumors. 17.08.1993

Tosedostat Treatment of acute myeloid leukemia 10.12.2008

trabectedin Yondelis Treatment of soft tissue sarcoma. 30.09.2004

trabectedin Yondelis Treatment of patients with ovarian cancer 29.03.2005

Tramadol hydrochloride Management of postherpetic neuralgia 26.04.2005

Tramadol hydrochloride Treatment of painful HIV-associated neuropathy 28.01.2005

Tranexamic acid Cyklokapron

Treatment of patients undergoing prostatectomy where there is hemorrhage or risk of hemorrhage as a result of increased fibrinolysis or fibrinogenolysis. 23.07.1987

Tranexamic acid Cyklokapron Treatment of hereditary angioneurotic edema. 09.09.1985

Tranilast Rizaben For the treatment of maligant glioma 02.12.2003

Transforming growth factor-beta 2 Treatment of full thickness macular holes. 18.12.1992

Transgenic human alpha 1 antitrypsin

Treatment of emphysema secondary to alpha 1 antitrypsin deficiency. 19.05.1999

Trastuzumab Herceptin

Treatment of patients with pancreatic cancer that overexpress p185HER2. 14.12.1999

Treosulfan Ovastat Treatment of ovarian cancer. 16.05.1994

Tretinoin ATRA-IV Treatment of acute and chronic leukemia. 14.01.1993

Tretinoin ATRA-IV Treatment of T-cell non-Hodgkin's lymphoma 11.04.2003

Tretinoinsurface epithelia (conjunctiva and/or cornea) with mucous deficiency and keratinization. 15.04.1985

tri-antennary glycotripeptide derivative of 5-fluorodeoxyuridine Treatment for hepatocellular carcinoma 23.11.2001

triciribine Treatment of multiple myeloma 01.02.2008

Triheptanoin Triheptanoin-SASOL Sp

Treatment of glycogen storage disorder II (Pompe disease) 01.02.2008

Triheptanoin Triheptanoim-SASOl SpTreatment of fatty acid disorders 26.05.2006

Trimetrexate Neutrexin Treatment of metastatic osteogenic sarcoma. 10.08.2000

Trimetrexate glucuronateTreatment of patients with advanced non-small cell carcinoma of the lung. 13.01.1988

Trimetrexate glucuronate Treatment of pancreatic adenocarcinoma. 25.07.1985

Trimetrexate glucuronate Treatment of metastatic colorectal adenocarcinoma. 25.07.1985

Trimetrexate glucuronateTreatment of metastatic carcinoma of the head and neck (i.e. buccal cavity, pharynx, and larynx). 25.07.1985

Triptorelin pamoate Decapeptyl Injection

For use in the palliative treatment of advanced ovarian carcinoma of epithelial origin. 10.08.1990

Trisaccharides A and B Biosynject

Treatment of moderate to severe clinical forms of hemolytic disease of the newborn arising from placental transfer of antibodies against blood group substances A and B. 12.04.1987

Trisaccharides A and B Biosynject

Prevention of ABO medical hemolytic reactions arising from ABO-incompatible bone marrow transplantation. 15.04.1988

Trisaccharides A and B

Treatment of moderate to very severe clinical forms of transfusion reactions arising from ABO incompatible transfusions of blood, blood products, and blood derivatives. 03.08.1987

Trisaccharides A and B Biosynject

For use in ABO-incompatible solid organ transplantation, including kidney, heart, liver and pancreas. 20.04.1987

Trisodium citrate concentration Hemocitrate For use in leukapheresis procedures. 15.06.1995

Trisodium zinc Diethylenetriaminepentaacetate

Treatment of patients with known or suspected internal contamination with plutonium, americium, or curium to increase the rate of elimination. 27.02.2004

Troxacitabine Troxatyl Treatment of acute myeloid leukemia 04.04.2005

Tumor necrosis factor-binding protein 1

Treatment of symptomatic patients with AIDS including all patients with CD4 counts less than 200 cells per mm3. 06.01.1993

Tumor necrosis factor-binding protein II

Treatment of symptomatic patients with the AIDS including all patients with CD4 T-cell counts less than 200 cells per mm3. 06.01.1993

Tyloxapol Supervent Treatment of cystic fibrosis. 08.03.1995

Type 1 native bovine skin collagen Treatment of diffuse systemic sclerosis 01.02.2008

tyrosine kinase inhibitor Treatment of mastocytosis 14.09.2005

Ubiquinol Ubi-Q-Nol, Li-Q-Nol Treatment of Huntington's Disease 12.04.2004

Ubiquinol, coenzyme Q10, ubiquinone UBI-Q-NOL Treatment of pediatric congestive heart failure 12.04.2004

Ubiquinone Ubi-Q-Gel Treatment of mitochondrial cytopathies. 14.12.1999

Unconjugated Chimeric (human-murine) G250 IgG monoclonal antibody Treatment of renal cell carcinoma. 22.03.2001

Urea for intravitreal injection Neurosolve Treatment of retinitis pigmentosa 14.12.2005

Uridine 5'-triphosphateTo facilitate the removal of lung secretions in the treatment of patients with primary ciliary dyskinesia. 26.06.1996

Uridine 5'-triphosphate Treatment of cystic fibrosis. 04.12.1995

Urofollitropin Fertinex

For the initiation and re-initiation of spermatogenesis in adult males with reproductive failure due to hypothalamic or pituitary dysfunction, hypogonadotropic hypogonadism. 05.12.1997

Urogastrone

For acceleration of corneal epithelial regeneration and healing of stromal incisions from corneal transplant surgery. 01.11.1984

ursodiol Ursofalk Suspension Treatment of cystic fibrosis liver disease 23.10.2007

Ursodiol Actigall

Management of the clinical signs and symptoms associated with primary biliary cirrhosis. 19.02.1991

Valine, isoleucine and leucine VIL Treatment of hyperphenylalaninemia 05.01.1996

valine-valine-ganciclovirTreatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HSV1 and HSV2. 21.05.2007

Valproate Treatment of fragile X syndrome 05.05.2008

Valproic acid, sodium PEAC Treatment of familial adenomatous polyposis 24.06.2005

Vandetanib Zactima

Treatment of patients with follicular thyroid carcinoma, medullary thyroid carcinoma, anaplastic thyroid carcinoma, and locally advanced and metastatic papillary thyroid carcinoma 21.10.2005

Vapreotide Sanvar Treatment of symptomatic carcinoid tumors 06.04.2004

vapreotide Sanvar

Treatment of esophageal variceal hemorrhage patients with portal hypertension. 10.01.2000

vapreotide Octastatin Treatment of gastrointestinal and pancreatic fistulas. 10.01.2000

vapreotide Octastatin

Prevention of early postoperative complications following pancreatic resection. 06.03.2000

vapreotide Sanvar Treatment of acromegaly 04.11.2003

varespladib sodiumPrevention of acute chest syndrome in at-risk patients with sickle cell disease 19.11.2007

Varicella Zoster Immune Globulin (Human) VariZIG

Passive immunization for the treatment of exposed, susceptible individuals who are at risk of complications from varicella 07.11.2006

vascular endothelial growth factor 165b

Treatment of advanced melanoma stages IIb through IV. 24.06.2008

Vasoactive intestinal peptide Treatment of Acute Respiratory Distress Syndrome. 09.03.2001

Vasoactive intestinal polypeptide Treatment of acute esophageal food impaction. 23.06.1993

veltuzumab Treatment of chronic lymphocytic leukemia 28.08.2008

Vibriolysin Vibrilase

Debridement of severe, deep dermal burns in hospitalized patients 16.06.2006

vigabatrin Sabril Treatment of infantile spasms. 12.06.2000

Viloxazine HCl Catatrol Treatment of narcolepsy. 11.06.1984

Viloxazine HCl Catatrol Treatment of cataplexy. 11.06.1984

vincristine sulfate liposome injection Marqibo Treatment of acute lymphoblastic leukemia. 08.01.2007

vincristine sulfate liposomes Marqibo (r) Treatment of metastatic uveal melanoma. 24.06.2008

Virulizin Virulizin Treatment of pancreatic cancer. 01.02.2001

viscous budesonide Treatment for pediatric eosinophilic esophagitis. 20.12.2006

vistonuridine An antidote in the treatment of 5-fluorouracil poisoning. 01.05.2009

vorinostat Treatment of multiple myeloma 12.06.2003

vorinostat Treatment of mesothelioma 17.03.2004

Vx-001

Treatment of telomerase reverse transcriptase (TERT) positive non-small cell lung cancer in HLA-A*0201 positive patients 20.02.2009

Xenogeneic hepatocytes HepatAssist Liver AssisTreatment of severe liver failure. 27.11.1998

Yttrium (90Y) antiferritin polyclonal antibodies Ferritarg P Treatment of Hodgkin's disease. 18.09.2006Yttrium-90 radiolabeled humanized monoclonal anti-carcinoembroyonic antigen IgG Cea-Cide Treatment of ovarian carcinoma. 03.08.1999

Zalcitabine Treatment of AIDS. 09.12.1986

Zosuquidar trihydrochloride Treatment of acute myeloid leukemia 15.12.2005

Sponsor Address

Cangene Corporation104 Chancellor Matheson Road

Winnipeg, ManitobaR3T 5Y3 CANADA

Wyeth Pharmaceuticals, Inc. P. O. Box 8299Philadelphia PA 19101-8299

Fleming & Company, Pharmaceuticals 1733 Gilsinn Lane Fenton MO 63026

Dey Laboratories2751 Napa Valley Corporate Drive Napa CA 94558

EMD Serono, Inc. One Technology Place Rockland MA 02370

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200Princeton NJ 08540

ONY, Inc. 1576 Sweet Home Road Amherst NY 14228

Dutch Ophthalmic Research Center Int'l BV Scheijdelveweg 2

P.O. Box 43 3214ZG Zuidland NETHERLANDS

GTC Biotherapeutics, Inc. 175 Crossing Blvd Framingham MA 01702

CSL Behring, LLC 1020 First Avenue P.O. Box 61501

King of Prussia PA 19406

Antisoma 300 Technology Square Cambridge MA 02139

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

GlaxoSmithKline1250 South Collegeville Road UP 4110

Collegeville PA 19426

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield NJ 07660

ViroPharma Incorporated 730 Stockton Drive Exton PA 19341

GE Healthcare, Inc. 101 Carnegie Center Princeton NJ 08540

GE Healthcare, Inc. 101 Carnegie Center Princeton NJ 08540

Talecris 8368 US 70 West Clayton NC 27520

Amgen, Inc. One Amgen Center DriveThousand Oaks CA 91320-1799

Prestwick Pharmaceuticals, Inc 1825 K Street NW Suite 1475Washington DC 20006

Bayer Pharmaceuticals Corporation 400 Morgan Lane West Haven CT 06516

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Spectrum Pharmaceuticals, Inc. 157 Technology Drive Irvine CA 92618

Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road Tarrytown NY 10591

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064-6157

Genzyme Corporation One Kendall SquareCambridge MA 02139-1562

Biomarin Pharmaceutical Inc. 371 Bel Marin Blvd. Novato CA 94949

Novartis Pharmaceutical Corporation One Health Plaza

East Hanover NJ 07936-1080

Eli Lilly and Company Lilly Corporate Center Drop Code 1853Indianapolis IN 46285

Topo Target A/S Fruebjergvej 3, 2100 Copenhagen DENMARK

IPSEN, Inc. 27 Maple Street Milford MA 01757

Gilead Colorado 7575 West 103rd Avenue Suite 102

Westminister CO 80021-5426

Novo Nordisk Inc. 100 College Road West Princeton NJ 08540

Wyeth Pharmaceuticals, Inc. P. O. Box 8299Phildelphia PA 19101-8299

Johnson & Johnson Pharmaceutical Research & Dev.

920 US Highway 202, P. O. Box 300 Raritan NJ 08869

Indevus Pharmaceuticals (Formerly Valera Pharma.) 33 Hayden Avenue Lexington MA 02421

Cangene Corporation 155 Innovation Drive CANADA

Baxter Healthcare Corporation One Baxter WayWest Lake Village CA 91362

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Grifols Biologicals Inc. 5555 Valley BoulevardLos Angeles CA 90032-3548

Salix Pharmaceuticals, Inc.1700 Perimeter Park Drive Morrisville NC 27560

Merck Sante, s.a.a. 37 rue Saint Romain 69008 Lyon FRANCE

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Merck & Co., Inc.P. O. Box 2000, RY 32-605 Rahway NJ 07065-0900

Dialysis Solutions, Inc. 14 Emmett Place Whitby, Ontario L1R 2B4 CANADA

Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Bristol-Myers Squibb Company 5 Research Parkway Wallingford CT 06492

Bristol-Myers Squibb Company 5 Research Parkway Wallingford CT 06492

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Eisai Medical Research, Inc. 6611 Tributary Street Suite 200Baltimore MD 21224

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Farmacon-IL, LLC 1720 Post Road East Suite 213Westport CT 06880-5643

Astellas Pharma US, Inc. Three Parkway North Deerfield IL 60015-2548

ImClone Systems Incorporated 33 ImClone Drive Branchburg NJ 08876

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Bayer Pharmaceutical Corporation 400 Morgan Lane West Haven CT 06516

Insmed, Inc.8720 Stony Point Parkway Suite 200

Richmond VA 23235

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

GlaxoSmithKline One Franklin Plaza Phildelphia PA 19101

Tercica, Inc.2000 Sierra Point Parkway Suite 400

Brisbane CA 94005

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

AR Holding Company, Inc. 1100 Orthodox Street Philadelphia PA 19124

Boehringer Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road P. O. Box 368

Ridgefield CT 06877-0368

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

BioMarin Pharmaceutical, Inc. 105 Digital Drive Novato CA 94949-5608

Bausch & Lomb Pharmaceuticals, Inc.

8500 Hidden River Parkway Tampa FL 33637

Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Canbridge MA 02139

Schering-Plough Reasearch Institute 2000 Galloping Hill Rd. Kenilworth NJ 07033

DynPort Vaccine Company LLC64 Thomas Johnson Drive Frederick MD 21702

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

CoTherix, Inc. 5000 Shoreline CourtSouth San Francisco CA 94080

Genzyme Corporation 4545 Horizon Hill Blvd.San Antonio TX 78229-2263

EMD Serono, Inc. One Technology Place Rockland MA 02370

Mayne Pharma (USA) Inc. Mack-Cali Centre II Second FloorParamus NJ 07652

Hameln Pharmaceuticals gmbh Langes Feld 13 Hameln GERMANY

Nutritional Restart Pharmaceutical, L.P.

4364 South Alston Avenue Durham NC 27713

Celgene Corporation 9900 W. 109th Street Suite 300

Overland Park KS 66210

Presutti Laboratories, Inc. 1607 N. Douglas Ave. Arlington Heights IL 60004

Presutti Laboratories, Inc. 1607 N. Douglas Avenue Arlington Heights IL 60004

Ipsen Limited 190 Bath Road Slough, Berkshire SL1 3XE UNITED KINGDOM

Amgen, Inc. One Amgen Center Drive

Thousand Oaks CA 91320-1799

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Cumberland Pharmaceuticals, Inc. 209 10th Street South Suite 332

Nashville TN 37203

EMD Serono, Inc. One Technology Place Roackland MA 02370

California Department of Health Services 2151 Berkeley Way Berkeley CA 94704-1011

Heyl Chemisch-Pharmzeutische Fabrik GMBH & Co, KG Goerzallee 253

D-14167 Berlin, Federal Republic of Germany GERMANY

Axcan Scandipharm Inc. 22 Inverness Parkway Suite 310Birmingham AL 35242

Actelion Pharmaceuticals Ltd Gewerbestrasse 16 CH - 4123 Allschwi SWITZERLAND

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

GlaxoSmithKline 2301 Renaissance Blv. P.O. Box 61540

King of Prussia PA 19406-2772

Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Cambridge MA 02139

BioMarin Pharmaceutical, Inc.371 Bel Marin Keys Boulevard, Suite 210 Novato CA 94949-5608

Genzyme Corporation One Kendall SquareCambridge MA 02139-1562

Sensus Corporation Suite 430, 98 San Jacinto BoulevardAustin TX 78701

Guilford Pharmaceuticals, Inc. 6611 Tributary Street Baltimore MD 21224

Baxter Healthcare Corporation Renal Division 1620 Waukegan RoadMcGaw Park IL 60085

Romark Laboratories, L.C.6200 Courtney Campbell Causeway Suite 880

Tampa FL 33607

Romark Laboratories, L.C.6200 Courtney Campbell Causeway Suite 880

Tampa FL 33607

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

Reckitt Benckiser Pharmaceuticals, Inc. 1901 Huguenot Road Richmond VA 23235

Reckitt Benckiser Pharmaceuticals, Inc. 1901 Huguenot Road Richmond VA 23235

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern PA 19355

United Therapeutics Corp. 68 T.W. Alexander Dr. P.O. Box 14186

Research Triangle Park NC 27709

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

Cell Therapeutics, Inc. 501 Elliott Ave. W. Suite 400Seattle WA 98119

Novartis Pharmaceuticals Corp. One Health PlazaEast Hanover NJ 07936-1080

Swedish Orphan AB Drottninggatan 98 SE-111 60 Stockholm SWEDEN

Actelion Life Sciences Ltd. 1840 Gateway Dr. 2nd FloorSan Mateo CA 94404

Johnson & Johnson Pharmaceutical R & D, LLC Route 202, P.O. Box 300 Raritan NJ 08869-0602

Novartis Pharmaceuticals Corp. 59 Route 10East Hanover NJ 07936-1080

Pharmacia and Upjohn Company 7000 Portage Road Kalamazoo MI 49001

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

Genzyme Corporation 4545 Horizon Hill Blvd.San Antonio TX 78229-2263

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92623-9534

Solstice Neurosciences, Inc. 40 General Warren Blvd Suite 160Malvern PA 19355

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Serono, Inc. One Technoloogy Place Rockland MA 02370

Serono, Inc. One Technology Place Rockland MA 02370

Protherics, Inc.1207 17th Ave. S., Suite 103 Nashville TN 37212

Cephalon 41 Moores Road PO Box 4011Frazer PA 19355

Pharmacia & Upjohn 7000 Portage Rd. 0633-298-113

Kalamazoo MI 49001-0199

EMD Serono, Inc. One Technology Place Rockland MA 02370

Wyeth-Ayerst Laboratories PO Box 8299Philadelphia PA 19101-8299

GlaxoSmithKline Five Moore Dr. PO Box 13398

Research Triangle Park NC 27709-3398

InterMune , Inc. 1710 Gilbreth Road, Suite 301

Burlingame CA 94010-1317

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

INO Therapeutics, Inc. 54 Old Highway 22 Clinton NJ 08809

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Pharmacia & Upjohn 7000 Portage Road Mail Stop: 0636-298-113

Kalamazoo MI 49001-0199

O.P.R. Development, L.P. 1501 Wakarusa Drive Lawrence KS 66047

Pharmacia & Upjohn Company 0634-298-113 7000 Portage Rd.

Kalamazoo MI 49001-0199

Schering-Plough Research Institute 2000 Galloping Hill Rd. Kenilworth NJ 07033

Alza Corporation 1550 Plymouth St. PO Box 7210

Mountain View CA 94039-7210

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400Conshohocken PA 19428

Immunex Corporation 51 University St. Seattle WA 98101-2936

Aventis Behring L.L.C. 1020 First Avenue PO Box 61501

King Of Prussia PA 19406-0901

Pacira Pharmaceuticals, Inc.10450 Science Center Drive San Diego CA 92121

Novo Nordisk, Inc. 100 Overlook Center Suite 200Princeton NJ 08540-7810

Teikoku Pharma USA, Inc. 745-D Camden Ave. Campbell CA 95008-4146

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

Otsuka Pharmaceutical Company Tokyo JAPAN

Eisai Medical Research, Inc 55 Challenger Road Ridgefield Park NJ 07660

Glaxo Wellcome Research and Development 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709

Cephalon, Inc. 145 Brandywine Parkway West Chester PA 19380

Massachussetts Public Health Biologic Laboratories 305 South Street Boston MA 02130-3597

Genzyme Corporation One Kendall Square Cambridge MA 02139

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

Anthra Pharmaceuticals, Inc.103 Carnegie Center, Suite 102 Princeton NJ 08540

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Glaxo Wellcome Research and Development 5 Moore Drive P.O. Box 13398

Research Triangle Park NC 27709

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Hoechst Marion Roussel P.O. Box 9627 Mail Station: H3-M2516

Kansas City MO 64134-0627

Mylan Laboratories, Inc. 781 Chestnut Ridge Road P.O. Box 4310

Morgantown WV 26504-4310

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

QOL Medical, LLC 12419 198th Drive, NE Woodinville WA 98072

Amgen, Inc. One Amgen Center Dr.Thousand Oaks CA 91320-1799

Hoechst Marion Roussel Frankfurt am Main P.O. Box 1140 Marburg GERMANY

Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton NJ 08543

MGI Pharma, Inc.5775 West Old Shakopee Rd. Suite 100

Bloomington MN 55437-3107

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Bryan Corporation 4 Plympton Street Woburn MA 01801

Novartis Pharmaceuticals Corp Drug Regulatory Affairs One Health Plaza

East Hanover NJ 07936-1080

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Axcan Pharma Inc. 597 Laurier BlvdMount St. Hilaire Quebec H7L 4S3

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Genentech, Inc. 1 DNA Way, MS 242South San Francisco CA 94080-4990

Genetics Institute, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Pharmacia & Upjohn 7000 Portage RoadKalamazoo MI 49001-0199

EMD Serono, Inc. One Technology Place Rockland MA 02370

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Bristol-Myers Squibb Pharmaceutical Research Institute 5 Research Parkway P.O. Box 5100

Wallingford CT 06492-7660

Valeant Pharmaceuticals 3300 Hyland Avenue Costa Mesa CA 92626

Orion Corporation P.O. Box 65 02101 ESPOO FINLAND

Roberts Pharmaceutical Corp. Meridian Center III 6 Industrial Way WestEatontown NJ 07724

Genetics Institute, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Lemmon Company 1510 Delp Drive Kulpsville PA 19443

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Teva Pharmaceuticals USA 1510 Delp Drive Kulpsville PA 19443

Serono One Technology Place Rockland MA 02370

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Liposome Company, Inc. One Research Way Princeton NJ 08540

Roxane Laboratories, Inc. PO Box 16532 Columbus OH 43216-6532

QOL Medical, LLC 12419 198th Drive, NE Woodinville WA 98072

Alza Corporation 950 Page Mill Rd. PO Box 10950Palo Alto CA 94303-0802

Guilford Pharmaceuticals, Inc. 6611 Tributary Street Baltimore MD 21224

Schier Ridgewood F.K.A. (Roberts Pharmaceutical Corp.) Meridian Center III 6 Industrial Way West

Eatontown NJ 07724

EMD Serono, Inc. One Technology Place Rockland MA 02370

Warner-Lambert Company 2800 Plymouth Road Ann Arbor MI 48106

SmithKline Beecham Pharmaceuticals One Franklin Plaza P.O. Box 7929

Philadelphia PA 19101

SmithKline Beecham Pharmaceuticals One Franklin Plaza P.O. Box 7929

Philadelphia PA 19101

Ferring Laboratories, Inc.400 Rella Boulevard, Suite 201 Suffern NY 10901

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92713

Catalytica Pharmaceuticals, Inc PO Box 1887 Greenville NC 27835-1887

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

NeXstar Pharmaceuticals, Inc. 650 Cliffside Drive San Dimas CA 91773

Bausch & Lomb Surgical, Chiron Vision Products 9342 Jeronimo Road Irvine CA 92718-1903

Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton NJ 08543

MedImmune & Massachussetts Public Health Biologics Labs.

35 West Watkins Mill Road Gaithersburg MD 20878

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

QLT Phototherapeutics, Inc. Lederle Laboratories401 North Middletown Road

Pearl River NY 10965

Rhone-Poulenc Rorer Pharmaceuticals, Inc.

500 Arcola Road, P.O. Box 1200 Collegeville PA 19426

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400

West Conshohocken PA 19428

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Immunex Corporation 51 University Street Seattle WA 98101

Wyeth-Ayerst Laboratories P.O. Box 8299 Philadelphia PA 19101

Pharmacia & Upjohn 7000 Portage RoadKalamazoo MI 49001-0199

Rh Pharmaceuticals, Inc.104 Chancellor Matheson Road Winnipeg, Manitoba CANADA

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Mylan Laboratories, Inc. 781 Chestnut Ridge Road P.O. Box 4310Morgantown WV 26504

Eon Labs Manufacturing, Inc.227-15 North Conduit Avenue Laurelton NY 11413

Jacobus Pharmaceutical Company 37 Cleveland Lane P.O. Box 5290

Princeton NJ 08540

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

Genzyme Corporation One Kendall SquareCambridge MA 02139-1562

MGI Pharma, Inc.5775 West Old Shakopee Rd. Suite 100

Bloomington MN 55437-3107

Aventis Behring L.L.C. 1020 First Avenue PO Box 61501

King of Prussia PA 19406-0901

Enzon, Inc. 20 Kingsbridge Road Piscataway NJ 08854

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Bayer Corporation Pharmaceutical Division 400 Morgan LaneWest Haven CT 06516

Bayer CorporationPharmaceutical Division, Biological Products 400 Morgan Lane

New Haven CT 06516

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400

West Conshohocken PA 19428

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Alcon Laboratories, Inc. 6201 South Freeway Fort Worth TX 76134 Bristol-Myers Squibb Pharmaceutical Research Institute

2400 West Lloyd Expressway Evansville IN 47721

Wallace Laboratories 301B College Road East Princeton NJ 08540

Chiron Corp. & Berlex Laboratories 4560 Horton Street Emeryville CA 94608

Biodevelopment Corporation8180 Greensboro Drive, Suite 1000 McLean VA 22102

Tap Pharmaceuticals, Inc. 2355 Waukegan Road Deerfield IL 60015

R. W. Johnson Pharmaceutical Research Institute Route 202, P.O. Box 300 Raritan NJ 08869

Bayer Corporation 1884 Miles Avenue Elkhart IN 46515

Cytogen Corporation 600 College Road East Princeton NJ 08540

Adria Laboratories, Inc. P.O. Box 16529 Columbus OH 43216

Unimed Pharmaceuticals, Inc. 901 Sawyer Rd. Marietta GA 30062

Sigma-Tau Pharmaceuticals, Inc.

9841 Washingtonian Blvd. Suite 500

Gaithersburg MD 20878

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Armour Pharmaceutical Company

500 Arcola Road, P.O. Box 1200 Collegeville PA 19426

SmithKline Beecham Pharmaceuticals One Franklin Plaza P.O. Box 7929

Philadelphia PA 19101

Bristol-Myers Squibb Pharmaceutical Research Institute 5 Research Parkway P.O. Box 5100

Wallingford CT 06492

Medtronic, Inc. 800 53rd Avenue N.E. Minneapolis MN 55432

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Syntex (USA), Inc. 3401 Hillview Avenue Palo Alto CA 94303

SmithKline Beecham Pharmaceuticals One Franklin Plaza P.O. Box 7929

Philadelphia PA 19101

Bayer CorporationPharmaceutical Division, Biological Products 400 Morgan Lane

New Haven CT 06516

Roberts Pharmaceutical Corp. Meridian Center III 6 Industrial Way WestEatontown NJ 07724

Immunex Corporation 51 University Street Seattle WA 98101

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

Elkins-Sinn, Inc. 2 Esterbrook Lane Cherry Hill NJ 08003

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

Berlex Laboratories, Inc.15049 San Pablo Avenue, P.O. Box 4099 Richmond CA 94804

Genzyme Corporation One Kendall SquareCambridge MA 02139-1562

Immunex Corporation 51 University Street Seattle WA 98101

Solopak Pharmaceutical Co. 1845 Tonne Road Elk Grove Village IL 60007

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400Conshohocken PA 19428

InterMune, Inc. 3280 Bayshore Blvd Brisbane CA 94005

Fresenius Medical Care North America 920 Winter Street Waltham MA 02451

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

United-Guardian, Inc. P.O. Box 2500 Smithtown NY 11787

Adria Laboratories, Inc. P.O. Box 16529 Columbus OH 43216

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

University of Michigan UH B1 H410/00281500 E. Medical Center Drive

Ann Arbor MI 48109-0028

Enzon, Inc. 20 Kingsbridge Road Piscataway NJ 08854

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92713

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92713

Fisons Corporation 755 Jefferson Rd P.O. Box 1710Rochester NY 14603

Pharmacia & Upjohn AB Lindhagensgatan 133 SE-112 87 SWEDEN

Ferring Laboratories, Inc.400 Rella Boulevard, Suite 201 Suffern NY 10901

Syntex (USA), Inc. 3401 Hillview Avenue Palo Alto CA 94304

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Somerset Pharmaceuticals, Inc.777 South Harbor Island Boulevard Tampa FL 33602

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Bristol-Myers Squibb Pharmaceutical Research Institute

5 Research Parkway, P.O. Box 5100 Wallingford CT 06492

Degussa Corporation 65 Challenger Road Ridgefield Park NJ 07660

Block Drug Company, Inc. 257 Cornelison Avenue Jersey City NJ 07302

Bock Pharmacal Company P.O. Box 419056Saint Louis MO 63141-9056

Galderma Laboratories, Inc. P.O. Box 331329 Fort Worth TX 76163

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Immunex Corporation 51 University Street Seattle WA 98101

Pak, Charles Y.C. M.D.

The University of Texas Health Scienc Center at Da

5323 Harry Hines Boulevard

Dallas TX 75235

Lederle LaboratoriesDivision of American Cyanamid Company 401 N. Middletown Road

Pearl River NY 10965

Immunex

Immunex 2525 McGaw Avenue P.O. Box 19791Irvine CA 92623

Lederle LaboratoriesDivision of American Cyanamid Company 401 N. Middletown Road

Pearl River NY 10965

Rhone-Poulenc Rorer Pharmaceuticals, Inc. 500 Arcola Road Collegeville PA 19426

Bayer CorporationPharmaceutical Division, Biological Products 400 Morgan Lane

New Haven CT 06516

Du Pont PharmaceuticalsE.I. Du Pont De Nemours & Co. Wilmington DE 19898

MGI Pharma, Inc.5775 West Old Shakoppe Rd. Suite 100

Bloomington MN 55437-3107

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Novartis Pharmaceutical Corporation 59 Route 10 East Hanover NJ 07936

Novartis Pharmaceutical Corporation 59 Route 10 East Hanover NJ 07936

EMD Serono, Inc. One Technology Place Rockland MA 02370

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Merck Sharp & Dohme Research

Division Of Merck And Company West Point PA 19486

Ethitek Pharmaceuticals, Inc.7855 Gross Point Road, Unit L Skokie IL 60077

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

University of Texas Health Science Center at Dallas 5323 Harry Hines Blvd Dallas TX 75235

University of Texas Health Science Center at Dallas 5323 Harry Hines Blvd Dallas TX 75235

University of Texas Health Science Center at Dallas

5323 Harry Hines Boulevard Dallas TX 75235

DuPont PharmaceuticalsE.I. Du Pont De Nemours & Co. Wilmington DE 19880

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Fisons Corporation 755 Jefferson Rd. P.O. Box 1710Rochester NY 14603

Solvay 901 Sawyer Road Marietta GA 30062

Abbott Laboratories Diagnostics Division Abbott Park IL 60064

Intarcia Therapeutics, Inc. 24650 Industrial Blvd Hayward CA 94545

Marshall Edwards, Inc. 140 Wicks Road AUSTRALIA

Marshal Edwards, Inc. 140 Wicks Road AUSTRALIA

Marshall Edwards, Inc. 140 Wicks Road AUSTRALIA

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Tibotec, Inc. 1020 Stony Hill Road Yardley PA 19067

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

Fujisawa Healthcare, Inc. Three Parkway North Deerfield IL 60015-2548

Global Alliance for TB Drug Development 80 Broad Street New York NY 10004

Pfizer Global Research and Development 50 Pequot Avenue New London CT 06320

Sigma-Tau Research, Inc. 9841 Washingtonian Blvd Suite 502Gaithersburg MD 20878

Adventrx Pharmaceuticals, Inc. 6725 Mesa Ridge Road Suite 100San Diego CA 92121

Inotek Pharmaceuticals Corporation 100 Cummings Center Beverly MA 01915

Otsuka Pharmaceutical Company, Ltd 2440 Research Blvd Rockville MD 20850

Abbott Laboratories 200 Abbott Park Road AP34/RA72

Abbott Park IL 60064-6188

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064

Abbott Laboratories 200 Abbaott Park Road AP34/RA72

Abbott Park IL 60064-6188

Phase 2 Discovery, Inc.3130 Highland Avenue, Third Floor Cincinnati OH 45219-2374

Phase 2 Discovery, Inc. 3130 Highland Ave. Third FloorCincinnati OH 45219

Ferrokin BioSciences, Inc. 2729 Debbie Court San Carlos CA 94070

Auris Medical, Inc. 211 East Ontario Street Chicago IL 60611

Winston Laboratories, Inc. 100 Fairway Drive Vernon Hills IL 60061

Molecular Insight Pharmaceuticals, Inc. 160 Second Street Cambridge MA 02142

Aeolus Pharmaceuticals, Inc.PO Box 14287; 79 T.W. Alexander Dr. 4401 Research

Research Triangle Park NC 27709

BioSynthema, Inc. 4041 Forest Park Avenue St. Louis MO 63108

Clinuvel Inc. 353 Sacramento Street San Francisco CA 94111

Oxford GlycoSciences 10, The Quadrant Abington Science ParkUnited Kingdom UNITED KINGDOM

S*BIO Pte., Ltd. 1 Science Park Road Singapore Science Park II SINGAPORE

Louisiana State University Medical Center Foundation 1600 Canal St. 10th Floor

New Orleans LA 70112

NeoRx Corporation 410 W. Harrison Street Seattle WA 98119-4007

Hologic, Inc. 1240 Elko Drive Sunnyvale CA 94089

Bristol-Myers Squibb Company Research & Development 5 Research Parkway

Wallingford CT 06492-7660

Amicus Therapeutics, Inc. 6 Cedar Brook Drive Cranbury NJ 08512

Amicus Therapeutics, Inc 6 Cedar Brook Drive Cranbury NJ 08512

HemaQuest Pharmaceuticals, Inc. 101 Federal Street Boston MA 02110

EntreMed, Inc.9640 Medical Center Drive Rockville MD 20850

EntreMed, Inc.Research Triangle Park Center Suite 400

Durham NC 27703

FoldRx Pharmaceuticals, Inc. 300 Technology Square Cambridge MA 02139

Callisto Pharmaceuticals, Inc. 2 Executive Drive Suite 450Somerset NJ 08873

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Repligen Corporation 41 Seyon Street Building 1, Suite 100Waltham MA 02453

Knopp Neurosciences, Inc. 2100 Wharton Street Pittsburgh PA 15203

BioQuant, Inc. 6330 Nancy Ridge Drive San Diego CA 92121

Abbott Laboratories

Global Pharmaceutical Research and Development 200 Abbott Park Road

Abbott Park IL 60064-6157

Abbott Laboratories

Global Pharmaceutical Research and Development Abbott Park IL 60064

Inologic, Inc. 101 Elliott Ave., West Seattle WA 98119

Kennedy & Hoidal, M.D.'sUniversity of Utah Health Sciences Center

50 North Medical Drive, Room 4R240

Salt Lake City UT 84132

Rexahn Corporation 9620 Medical center Drive Rockville MD 20850

Rexahn Corporation9620 Medical Center Drive Rockville MD 20850

Rexahn Corporation 9620 Medical center Drive Rockville MD 20850

Rexahn Corporation9620 Medical Center Drive Rockville MD 20850

Rexahn Corporation9620 Medical Center Drive Rockville MD 20850

National Cancer Institute, DctNIH, Exec. Plaza N., Room 7-18 Bethesda MD 20892

Lemmon Company 1510 Delp Drive Kulpsville PA 19443

Lawrence Panasci, MDProfessor of Medicine, McGill University 3755 Cote Ste Catherine

Montreal, Quebec H3T 1E2 CANADA

Pangene Corporation 5500 Stewart Avenue Fremont CA 94538

Grant, Steven M.D.Massey Cancer Center, VCU P.O. Box 980230

Richmond VA 23298-0230

Neurophyxia B.V. Onderwijsboulevard 219 NETHERLANDS

PR Pharmaceuticals, Inc. 1716 Heath Parkway Fort Collins CO 80524

EntreMed, Inc.9640 Medical Center Drive Rockville MD 20850

EntreMed, Inc.9640 Medical Center Drive Rockville MD 20850

EntreMed, Inc.9640 Medical Center Drive Rockville MD 20850

Prosena B.V. Einsteinweg 55 NETHERLANDS

Sugen, Inc. 230 East Grand Ave.South San Francisco CA 94080

Sugen, Inc. 230 East Grand Ave.South San Francisco CA 94080-4811

Jacobus Pharmaceutical Company 37 Cleveland Avenue P.O. Box 5290

Princeton NJ 08540

Elliot Danforth, Jr., M.D. University of Vermont 84 Beartown RoadUnderhill VT 05489

PTC Therapeutics, Inc. 100 Corporate Court South Plainfield NJ 07080

PTC Therapeutics 100 Corporate Court South Plainfield NJ 07080

PTC Therapeutics, Inc. 100 Corporate Court South Plainfield NJ 07080

Berlex Laboratories, Inc. 1401 Harbor Bay Parkway Alameda CA 94501

Seaside Therapeutics 840 Memorial Drive Cambridge MA 02139

Dynogen Pharmaceuticals, Inc. 52 Second Avenue Waltham MA 02451

NeuroSearch Sweden AB Scerige Pederstrupvej 93 SWEDEN

Kiadis Pharma Canada, Inc. 2525 Marie Curie Canada H4S 2E1 CANADA

Kiadis Pharma Canada, Inc. 2525 Marie Curie CANADA

Kiadis Pharma Canada, Inc. 2525 Marie Curie Canada H4S 2E1 CANADA

Kiadis Pharma Canada, Inc. 2525 Marie-CurieSaint-Laurent (Quebec) H4S 2E1 CANADA

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming CANADA

Conatus Pharmaceuticals, Inc. 4365 Executive Drive San Diego CA 92121

SuperGen, Inc. 4140 Dublin Blvd Dublin CA 94568

Biomedical Frontiers, Inc. 1095 10th Ave., S.E. Minneapolis MN 55414

Metabasis Therapeutics, Incorporated

11119 North Torrey Pines Road LaJolla CA 92037

Acorda Therapeutics, Inc. 15 Skyline Drive Hawthorne NY 10532

Jacobus Pharmaceutical Co., Inc. 37 Cleveland Lane Princeton NJ 08540

Beeken, Warren M.D. University Of Vermont Given C-317Burlington VT 05405

Trophos SAParc scientifique de Lumigny, Case 931 1322 Marseille cedex FRANCE

Johnson & Johnson Pharmaceutical Research & Dev, 920 U S Highway 202 P.O. Box 300

Raritan NJ 08869

SIGA Technologies, Inc. 4575 SW Research Way Suite 230Corvallis OR 97333

SIGA Technologies, Inc. 4575 SW Research Way Suite 230Corvallis OR 97333

ClinTec International Ltd./Caledonia Pharma Ltd. Guerickestrasse 25 80805 Munich, GERMANY

Reata Pharmaceuticals, Inc.1950 N. Stemmons Freeway Dallas TX 75207-3199

Now Pharm AG 241, route d'Arlon L-1150 LUXEMBOURG

ILEX Oncology, Inc. 4545 Horizon Hill Blvd.San Antonio TX 78229-2263

Humanetics, Inc. 10400 Viking Drive Eden Prairie MN 55344

Sirtris Pharmaceuticals, Inc. 200 Technology Square Cambridge MA 02139

GlaxoSmithKline Five Moore Dr. P.O. Box 13398

Research Triangle Park NC 27709-

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

Celgene Corporation 9900 W. 109th Street Suite 300

Overland Park KS 66210

Xechem International, Inc.New Brunswick Technoloogy Center Building 1, Suite 310

New Brunswick NJ 08901-3279

Hana Biosciences, Inc. 7000 Shoreline Court Suite 370

South San Francisco CA 94080

InterMune, Inc. 3280 Bayshore Blvd Brisbane CA 94005

Clavis Pharma ASA Parkveien 53 B NORWAY

Intercept Pharmaceuticals, Inc. 18 Desbrosses Street New York NY 10013

Cornerstone Pharmaceuticals, Inc. 25 Health Science Drive Stony Brook NY 11790

Intercept Pharmaceuticals, Inc. 18 Desbrosses Street New York NY 10013

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

Therakos, Inc.Oaklands Corporate Center 437 Creamery Way

Exton PA 19341

Therakos, Inc.Oaklands Corporate Center 437 Creamery Way

Exton PA 19341

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92623-9534

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

NovoMed Pharmaceuticals, Inc. P.O. Box 900Germantown MD 20875-0900

Celgene Corporation 7 Powder Horn DriveWarren NJ 07059

Burzynski Research Institute, Inc. 9432 Old Katy Road Houston TX 77055

Center for Cellular & Molecular Therapeutics

The Children's Hospital of Philadelphia Philadelphia PA 19104

La Jolla Pharmaceutical Co. 6455 Nancy Ridge Dr. San Diego CA 92121

Menarini Ricerche S.p.A. Via Tito Speri 10 Pomezia Roma ITALY

Bristol-Myers Squibb Company P.O. Box 4500 Princeton NJ 08543-4500

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064-6188

Amsterdam Molecular Therapeutics BV P. O. Box 22506 NETHERLANDS

Avigen, Inc. 1301 Harbor Bay Parkway Alameda CA 94502

Avigen, Inc. 1301 Harbor Bay Parkway Alameda CA 94502

Applied Genetic Technologies Corporation 11801 Research Drive Alachua FL 32615

Applied Genetic Technologies Corporation 11801 Research Drive Alachua FL 32615

Fondazione TelethonVia Guglielmo Saliceto, 5/a ITALY

Targeted Genetics Corporation1100 Olive Way, Suite 100 Seattle WA 98101

Medco Research, Inc. 8455 Beverly Boulevard Suite 308Los Angeles CA 90048

Advantagene, Inc. 160 Paulson Road Waban MA 02468

GenStar Therapeutics Corporation 10835 Altman Row Suite 150

San Diego CA 92121

Ark Therapeutics Ltd 6 Warren Mews London W1T6AR London UNITED KINGDOM

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Alpha Gal, LLC

a Kentucky Bioprocessing (KBP) subsidiary 3700 Airpark Drive

Owensboro KY 42301

TolerRX, Inc. 300 Technology Square Cambridge MA 02139

AutoImmune, Inc. 128 Spring Street Lexington MA 02173

MotoGen, Inc. 3 Pine View Road Mount Kisco NY 10549

Aldagen, Inc. 2810 Meridian Parkway Durham NC 27713

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Chiron Corporation 4560 Horton St. Emeryville CA 94608-2916

Chiron Corporation 4560 Horton St. Emeryville CA 94608-2916

Astellas Pharma US, Inc. Three Parkway North Deerfield IL 60015-2548

Merck & Co., Inc. 126 East Lincoln Ave. Rahway NJ 07065-0900

Richard J. Wenstrup, M.D.Division of Human Genetics

Children's Hospital Research Foundation

Cincinnati OH 45229-3039

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Genzyme Corporation One Kendall SquareCambridge MA 02139-1562

Atlantic Healthcare Limited Maple House Halsted, Essex CO9 4BB UNITED KINGDOM

Ligand Pharmaceuticals, Inc. 10275 Science Center Dr. San Diego CA 92121-1117

Alwyn Company, Inc. 2301 Highway 60 East Lake Crystal MN 56055

Pervasis Therapeutics, Inc. One Kendall Square First FloorCambridge MA 02139

Bayer Healthcare Pharmaceuticals, Inc. Post Office Box 1000

50 Division Street, Suite 503

Montville NJ 07045-1000

Angioblast Systems, Inc. 275 Madison Avenue New York NY 10016

Applied Immunotherapeutics, LLC

14132 E. Firestone Boulevard

Santa Fe Springs CA 90670

Neurotech USA, Inc. 6 Blackstone Valley Place Lincoln RI 02865

MolMed S.p.A. Via Olgettina 58 Milan 20132 ITALY

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Research Triangle Park NC 27709

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Research Triangle Park NC 27709

Burroughs Wellcome Company 3030 Cornwallis RoadResearch Triangle Pk NC 27709

Bio Products LaboratoryDagger Lane, Elstree, Hertfordshire WD6 3BX UNITED KINGDOM

Bio Products Laboratory Dagger Lane Elstree, Hertfordshire UNITED KINGDOM

Chiron Corporation 4560 Horton Street Emeryville CA 94608-2916

Kamada, Ltd. 7 Sapir Street Ness Ziona ISRAEL

Kamada Ltd. Kiryat Weizmann ISRAEL

Kamada Ltd. Kiryat Weizmann ISRAEL

CSL Behring LLC 1020 First Avenue King of Prussia PA 19406

CSL Behring L.L.C. 1020 First Ave. PO Box 61501

King of Prussia PA 19406-0901

Desnick, Robert J. M.D.The Mount Sinai School Of Medicine

Fifth Avenue at 100th Street, Box 1203

New York NY 10029

David Calhoun, Ph.D. Department of ChemistryConvent Avenue & 138th Street

New York NY 10031

Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

National Institute of Diabetes, and Digestive and Kidney Diseases

National Institutes of Health, 31 Center Drive MSC Building 31, Room 9N-222

Bethesda MD 20892-2560

Penwest Pharmaceuticals Company 39 Old Ridgebury Road Suite 11

Danbury CT 06810

Schwarz Pharma, Inc. P.O. Box 2038 Milwaukee WI 53201

Daniel F. Hanley, MD Johns Hopkins University600 N. Wolfe St., Jefferson 1-109

Baltimore MD 21287

Sanofi-Aventis US, Inc. 55 Corporate Drive Bridgewater NJ 08807

Ablynx NV Technologiepark 4 B-9052 Zwijnaarde BELGIUM

Amgen Inc. One Amgen Center DriveThousand Oaks CA 91320-1799

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune LLC One MedImmune Way Gaithersburg MD 20878

Medimmune, LLC One MedImmune Way Gaithersburg MD 20878

Medimmune LLC One MedImmune Way Gaithersburg MD 20878

Transave, Inc. 11 Deer Park DriveMonmouth Junction NJ 08852-1923

Glaxo Wellcome Research and Development 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709

Eastern Virginia Medical SchoolDepartment of Ophthalomology

880 Kempsville Road, Suite 2500

Norfolk VA 23502-3990

DUSA Pharmaceuticals, Inc. 25 Upton Drive Wilmington MA 01887

Syncom Pharmaceuticals, Inc. 66 Hanover Road Florham Park NJ 07932

The Institute for One World Health 580 California Street San Francisco CA 94104

Kanyok, Thomas P. Pharm.D.University of Illinois at Chicago College of Pharm

833 South Wood Street (m/c886) Rm. 176

Chicago IL 60612

Kanyok, Thomas P. Pharm.D.University Of Illinois At Chicago College of Pharm

833 South Wood Street (m/c886) Rm. 176

Chicago IL 60612

Kanyok, Thomas P. Pharm.D.University of Illinois at Chicago College of Pharm

833 South Wood Street (m/c886) Rm. 176

Chicago IL 60612

Academic Pharmaceuticals, Inc.21 N. Skokie Valley Highway Suite G3

Lake Bluff IL 60044

Pipex Pharmaceuticals, Inc. 3930 Varsity Drive Ann Arbor MI 48108

Pipex Pharmaceuticals, Inc. 3930 Varsity Drive Ann Arbor MI 48108

Xanthus Pharmaceuticals, Inc. 300 Technology Square Cambridge MA 02139

Novartis Pharmaceuticals Corporation 150 Industrial Road San Carlos CA 94070

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

Celgene Corporation 9900 W. 109th Street Suite 300

Overland Park KS 66210

Warner-Lambert Company

Parke-Davis Pharmaceutical Research Division 2800 Plymouth Road

Ann Arbor MI 48106

Akorn, Inc. 2500 Millbrook Drive Buffalo Grove IL 60089

Roberts Pharmaceutical Corp. Meridian Center II 4 Industrial Way WestEatontown NJ 07724-2274

Roberts Pharmaceutical Corp. Meridian Center II 4 Industrial Way WestEatontown NJ 07724-2274

Genzyme Corporation One Kendall Square Cambridge MA 02139

Scios, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Scios, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Xytis, Inc.400 South El Camino Real Suite 1200

San Mateo CA 94402-1703

Knoll Pharmaceutical Company3000 Continental Dr., North Mt. Olive NJ 07828

Maret Pharmaceutical Corporation

4041 MacArthur Boulevard, Suite 375 Newport Beach CA 92660

Maret Pharmaceuticals 4041 MacArthur Blvd. Suite 375

Newport Beach CA 92660

Cangene Corporation 155 Innovation Drive R3T 5Y3 CANADA

Novartis Pharmaceuticals Corporation One Health Plaza East Hanover NJ 07936

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

AEterna Zentaris, Inc. Dr. Claude HaritonChief Medical Officer, VP, Cli

Quebec G1P 4P5, Canada CANADA

Biogen IDEC, Inc. 5200 Research PlaceSan Diego CA 92122

Xencor, Inc. 111 W. Lemon Avenue Monrovia CA 91016

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Baxter Healthcare Corporation 1620 Waukegan Road Mcgaw Park IL 60085

Xenova Biomedix Limited CELTIC PHARMA 957 Buckingham Avenue Berkshire SL1 4NL UNITED KINGDOM

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Pfizer Global Research & Development 50 Pequot Avenue New London CT 06320

Children's Hospital 700 Children's Drive Columbus OH 43205

Bayer HealthCare LLC 555 Whiteplains Road Tarrytown NY 10591-5124

Advanced Biotherapy, Inc.6355 Topanga Canyon Blvd. Suite 510

Woodland Hills CA 91367

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Burzynski Research Institute, Inc. 9432 Old Katy Road Houston TX 77055

Upsher-Smith Laboratories, Inc 4905 23rd Avenue North Minneapolis MN 55447

Lorus Therapeutics, Inc. 2 Meridan Road M9W 4Z7 CANADA

Lorus Therapeutics, Inc 2 Meridan Road M9W427 CANADA

Genzyme Corporation Drug & Biomaterial R&D 153 Second AvenueWaltham MA 02451

CoDa Therapeutics, Inc.10505 Sorrento Valley Road San Diego CA 92121

Tolera Therapeutics, Inc. 4717 Campus Drive #800 Kalamazoo MI 49008

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Bradmer Pharmaceuticals, Inc.9900 Corporate Campus Drive Suite 3000

Louisville KY 40223

CSL Behring 1020 First Ave. PO Box 61501

King of Prussia PA 19406-0901

American National Red Cross9312 Old Georgetown Road Bethesda MD 20814

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Applied Medical Research 1600 Hayes Street Nashville TN 37203

Fresenius Biotech North America 920 Winter Street Waltham MA 02451

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd Franklin TN 37067

Ophidian Pharmaceuticals, Inc.5445 East Cheryl Parkway Madison WI 53711

Archemix Corporation 300 Third Street Cambridge MA 02142

Ariad Pharmaceuticals, Inc. 26 Landsdowne St.Cambridge MA 02139-4234

Wyeth-Lederle Vaccines and Pediatrics 211 Bailey Rd.

West Henrietta NY 14586-9728

Scherer DDS Frankland Road Swindon SN5 8RU Wiltshire UNITED KINGDOM

Pentech Pharmaceuticals, Inc. 1110 Lake Cook Rd. Suite 257Buffalo Grove IL 60089

NeuroHealing Pharmaceuticals, Inc. 50 Undine Road Newton MA 02135

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

MolMed S.p.A. Via Olgettina 58 Milan ITALY

Vertex Pharmaceuticals Inc. 130 Waverly StreetCambridge MA 02139-4242

Perrine, Susan P., M.D. Boston University Cancer Research CenterBoston MA 02118

CytRx Corporation 3030 Bunker Hill Street Suite 105San Diego CA 92109

Floyd R. Sallee, M.D., Ph.D.University of Cincinnati School of Medicine/

P. O. Box 670669 231 Albert Sabin Way

Cincinnati OH 45267-0559

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon Inc 41 Moores Road P. O. Box 4011Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road P.O. Box 4011Frazer PA 19355

Novartis Pharmaceuticals Bldg 405/4051 One Health Plaza

East Hanover NJ 07936-1080

World Health Organization

Special Programme for Research and Training in Tro Via Appia , Geneva 27 SWITZERLAND

US Army Medical Materiel Development Activity

Office of the Surgeon General 622 Neiman Street

Ft. Detrick MD 21702-9240

Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

NPDC-AS101, Inc. 783 Jersey Avenue New Brunswick NJ 08901

McGuff Pharmaceuticals Inc. 2921 W. McArthur Blvd. Santa Ana CA 92704-6929

Eli Lilly & Company Lilly Corporate Center Indianapolis IN 46285

GlaxoSmithKline, Inc. 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709

GlaxoSmithKline, Inc. 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709-

TVAX Biomedical, LLC 8060 Reeder Street Lenexa KS 66214-1554

Dendreon Corporation 3005 First Avenue Seattle WA 98121

Cellular Bioengineering, Inc. 1946 Young Street Honolulu HI 96826

Northwest Biotherapeutics, Inc. 22322 20th Avenue SE Suite 150Bothell WA 98021

Avax Technologies, Inc.9200 Indian Creek Parkway Building 9, Suite 200

Overland Park KS 66210

Proneuron Biotechnologies, Inc. 2029 Century Park East Sixth FloorLos Angeles CA 90067

Kiadis Pharma Canada, Inc. 2525 Marie CurieMontreal (Quebec) H4S 2E1 CANADA

RhinoCyte, Inc. 201 E. Jefferson Street Louisville KY 40202-1246

RhinoCyte, Inc. 201 E. Jefferson Street Louisville KY 40202-1246

TissueTech, Inc. 7000 SW 97th Avenue Miami FL 33173

Antigenics, Inc. 3 Forbes Rd. Lexington MA 02421

Antigenics, Inc. 3 Forbes Rd. l MA 02421

Cytogen Corporation 600 College Road East CN 5308Princeton NJ 08540-5308

Biogen Idec MA, Inc. 14 Cambridge Center Cambridge MA 02142

Pfizer, Inc.10646 Science Center Drive San Diego CA 92121

Oral Solutions, Inc.787 Seventh Ave., 48th Floor New York NY 10019

Gilead Sciences (formerly Corus Pharma) 2025 First Ave. Suite 800

Seattle WA 98121

OncoVac Corporation P. O. Box 970Pacific Palisades CA 90272

A. L. Laboratories, Inc. One Executive Drive P.O. Box 1399Fort Lee NJ 07024

Infusaid, Inc. 1400 Providence Highway Norwood MA 02062

Medtronic, Inc. 800 53rd Avenue N.E. P.O. 1250

Minneapolis MN 55440-9087

Medtronic Neurological710 Medtronic Parkway NE

Minneapolis MN 55432-5604

Reata Pharmaceuticals, Inc. 2801 Gateway Drive Irving TX 75063

Eurand Pharmaceuticals, Inc. 790 Township Line Road Yardley PA 19067

DOR BioPharma, Inc. 29 Emmons Drive Suite C-10Princeton NJ 08540

DOR BioPharma, Inc. 29 Emmons Drive Suite C-10Princeton NJ 08540

DOR BioPharma, Inc. 29 Emmons Drive Suite C-10Princeton NJ 08540

Bristol-Myers Squibb Company P. O. Box 4000 Princeton NJ 08543-4000

Fallien Cosmeceuticals Ltd. 677 W. Dekalb Pike King of Prussia PA 19406

Angelini Pharmaceuticals, Inc. 70 Grand Avenue River Edge NJ 07661

AllerQuest LLC 836 Farmington Avenue Suite 207

West Hanford CT 06119-1551

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

LungRx, Inc. 1104 Spring Street Silver Spring MD 20910

Dovetail Technologies, Inc.Bldg. 337, Paint Branch Drive College Park MD 20742

Dovetail Technologies, Inc.Bldg. 337, Paint Branch Drive College Park MD 20742

Floyd R. Sallee, M.D., Ph.D.University of Cincinnati School of Medicine ML 0559

Cincinnati OH 45267-0559

Medco Research, Inc. 8455 Beverly Blvd. Suite 308Los Angeles CA 90048

Medco Research, Inc. 8455 Beverly Blvd. Suite 308Los Angeles CA 90048

Advanced Life Sciences, Inc. (ALS) 1440 Davey Road Woodridge IL 60517

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Genentech, Inc. 1 DNA Way, MS #242 South San Francisco CA 94080-4990

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Alimentary Health LimitedCork Airport Business Park, Building 2800 Cork IRELAND

Alimentary Health Limited Guardwell, Kinsale County Cork IRELAND

Angelini Pharmaceuticals, Inc. 70 Grand Avenue Suite 109River Edge NJ 07661

Excorp Medical, Inc. Suite 235 7200 Hudson Blvd.Oakdale MN 55128

TissueTech, Inc. 7000 SW 97th Avenue Miami FL 33173

ICAgen Inc. Ion Channel Advances PO Box 14487Durham NC 27709

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

The Medicines Company 8 Sylvan Way Parsippany NJ 07054

Genetronics, Inc.11199 Sorrento Valley Rd. San Diego CA 92121-1334

Bristol-Myers Squibb 5 Research Parkway Wallingford CT 06492

Actelion Pharmaceuticals Ltd Gewerbestrasse 16 CH-4123 SWITZERLAND

Wyeth Pharmaceuticals, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Ipsen Limited 1 Bath Rd., Maidenhead Berkshire SL6 4UH UNITED KINGDOM

Ipsen Biopharm Limited 1 Bath Road MaidenheadBerkshire, SL6 4UH UNITED KINGDOM

Porton International, Inc.1155 15th Street, N.W., #315 Washington DC 20005

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92623-9534

Botulinum Toxin Research Associates, Inc.

1261 Furnace Brook Parkway Quincy MA 02169

Ipsen Limited 27 Maple Street Milford MA 01757-3650

Ipsen Limited (name changed from Porton International Inc) 27 Maple Street Milford MA 01757-3650

Hastings, Donald DVM1030 North Parkview Drive Bismarck ND 58501

GalaGen, Inc.4001 Lexington Avenue North Arden Hills MN 55126

Biomune Systems, Inc.540 Arapeen Drive, Suite 202 Salt Lake City UT 84108

Mount Sinai Medical CenterOne Gustave L. Levy Place New York NY 10029

Allergan, Inc. 2525 Dupont Dr. P.O. Box 19534Irvine CA 92623-9534

UCB Pharma, Inc. 1950 Lake Park Drive Smyra GA 30080

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd. San Mateo CA 94404

Boehringer Ingelheim Pharmaceuticals, Inc.

900 Ridgebury Road, Box 368 Ridgefield CT 06877-0368

NeoPharm, Inc.225 East Deerpath, Suite 250 Lake Forest IL 60045

GPC Biotech, Inc. 610 Lincoln Street Waltham MA 02451

Digestive Care, Inc. 1120 Win Drive Bethlehem PA 18017

Alpha Pharmaceuticals, LLCOne New England Avenue Piscataway NJ 08854

Sparta Pharmaceuticals, Inc. 111 Rock Road Horsham PA 19044-2310

SuperGen, Inc. 4140 Dublin Boulevard Dublin CA 94568

SuperGen, Inc. 4140 Dublin Blvd Suite 200Dublin CA 94568

SuperGen, Inc.Two Annabel Lane, Suite 220 San Ramon CA 94583

USC-CHLA Institute for Pediatric Clinical Research

Childrens Hospital of Los Angeles MS 55 Los Angeles CA 90027

USC-CHLA Institute for Pediatric Clinical Research

Childrens Hospital of Los Angeles 4650 Sunset Blvd, MS 55

Los Angeles CA 90027

Shire Laboratories Inc. 1550 East Gude Drive Rockville MD 20850

Shire Laboratories Inc. 1550 East Gude Drive Rockville MD 20850

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700Triangle Pk NC 27709

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

CSL Behring L.L.C. 1020 First Ave. PO Box 61501

King of Prussia PA 19406-0901

Baxter Healthcare Corp. One Baxter WayWestlake Village CA 91362

Baxter Healthcare Corp.Hyland Division (Baxter Hyland) 550 North Brand Blvd.

Glendale CA 91203

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Sandoz Pharmaceuticals Corp. 59 Route 10 East Hanover NJ 07936

Pharmedic Company28101 Ballard Road, Suite F Lake Forest IL 60045

R & D Laboratories, Inc. 4204 Glencoe Avenue Marina Del Rey CA 90292

Calgonate Corp. 3310 South Ocean Blvd Unit 132

Highland Beach FL 33487

Calgonate Corporation 3310 South Ocean Blvd Unit 132

Highland Beach FL 33487

Paddock Laboratories, Inc.3940 Quebec Avenue North Minneapolis MN 55427

Pneuma Pharmaceuticals, Inc. 1576 Sweet Home Road Suite 114Amherst NY 14228

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Anesiva, Inc. 650 Gateway BlvdSouth San Francisco CA 94080

NeurogesX, Inc. 981F Industrial Road San Carlos CA 94070

NeurogesX, Inc. San Carlos Business Park 981F Industrial Road

San Carols CA 94070-4117

Orphan Europe Immeuble "Le Guillaumet" Cedex 70 FRANCE

INO Therapeutics 6 Route 173 Clinton NJ 08809

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Digna Biotech, S.L.Avenids Carlos III de Noble Pamplona (Navarra) SPAIN

Proteolix, Inc. 333 Allerton AvenueSouth San Francisco CA 94080

Direct Therapeutics, Inc. 460 Seaport Court Suite 220Redwood CA 94063

Intramed Corporation 102 Tremont Way Augusta GA 30907

Fresenius Biotech North America, Inc. 99 Hayden Avenue Lexington MA 02420-9192

SmithKline BeechamRoute 23 & Woodmont Ave., P.O. Box 1510 King Of Prussia PA 19406

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Celltech Chiroscience Limited 216 Bath Road Slough SL1 4EN UNITED KINGDOM

Pfizer Global Research & Development MS 6025-B4179 50 Pequot Avenue

New London CT 06320

Mass General Hospital Merit E. Cudkowicz, MD, MSc

Building 149 13th Street, Room 2274

Charlestown MA 02129

Aastrom Biosciences Incorporated P.O. Box 376 Ann Arbor MI 48106

Eleos, Inc. 3033 Campus Drive Plymouth MN 55441

Eleos, Inc. 7824 Jackson Street Omaha NE 68114

Eleos, Inc.One Valmont Plaza - Corporate Headquarters Omaha NE 68154

Istituto Bioclon S.A. de C.V.Calzada de Tlalpan No. 4687 Tlalpan MEXICO

Advanced LIfe Sciences, Inc. 1440 Davey Road Woodridge IL 60517

Baker Cummins Pharmaceuticals, Inc.

ImClone Systems Incorporated 33 ImClone Drive Branchburg NJ 08876

Dr. Falk Pharma GmbH Leinenweberstrasse 5 9041 Freiburg, GERMANY GERMANY

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Wilex Biotechnology GmbH Grillparzerstrasse 10B 81675 Munich GERMANY

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Thallion Pharmaceuticals, Inc. 7150 Alexander-FlemingMontreal, Quebec, H4S 2C8 CANADA

Morphotek, Inc. 210 Welsh Pool Road Exton PA 19341

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

CSl Limited 45 Poplar Road AUSTRALIA

Biosynexus, Inc. 9298 Gaither Road Rockville MD 20877

Procter & Gamble CompanySharon Wood Technical Center

11370 Reed Hartman Highway

Cincinnati OH 45241

TransMolecular, Inc. 840 Memorial Drive Cambridge MA 02139

TransMolecular, Inc. 840 Memorial Drive Cambridge MA 02139

Trophos SAParc scientifique de Luminy 13288 Marseille cedex FRANCE

Cincinnati Children's Hospital Medical Center 3333 Burnet Ave. MLC 5006

Cincinnati OH 45229-3039

Alan L. Buchman, M.D., M.S.P.H.

Feinberg School of Medicine, Dept. of Gastroentero

676 N. St. Clair St., Suite 1400

Chicago IL 60611

Bioniche Pharma USA LLC 272 E. Deerpath Road Suite 304Lake Forest IL 60045

Curis, Inc. 61 Moulton Street Cambridge MA 02138

Bausch & Lomb Pharmaceuticals, Inc. 8500 Hidden River Pkwy. Tampa FL 33637

Gilead Sciences, Inc. 77575 W. 103rd Avenue Suite 102Westminster CO 80021

EMD Serono, Inc. One Technology Place Rockland MA 02370

Regeneron Pharmaceuticals Inc777 Old Saw Mill River Road Tarrytown NY 10591

Syntex-Synergen Neuroscience 3200 Walnut Street Boulder CO 80301

Syntex-Synergen Neuroscience 3200 Walnut Street Boulder CO 80301

Transave, Inc. 11 Deer Park DriveMonmouth Junction NJ 08852-1923

Matrix Pharmaceutical, Inc. 34700 Campus Drive Fremont CA 94555-3612

Matrix Pharmaceutical, Inc. 34700 Campus Drive Fremont CA 94555-3612

Winston Laboratories, Inc.100 Fairway Drive, Suite 134 Vernon Hills IL 60061

Ortho Biotech Oncology Research & Development

Johnson & Johnson Pharmaceutical Research & Dev., 920 US Highway 202

Raritan NJ 08869

Ortho Biotech Oncology Research & Development

Unit of J & J Pharmaceutical Research & Developmen P. O. Box 300

Raritan NJ 08869

Johnson & Johnson Pharmaceutical R & D, LLC 920 Route 202 PO Box 300

Raritan NJ 08869-0602

Ortho Biotech Oncology Research & Development

Unit of J & J Pharmaceutical Research & Dev., LLC

920 Route 202 South, P.O. Box 300

Raritan NJ 08869-0602

Actelion Pharmaceuticals Ltd. Gewerbestrasse 16 SWITZERLAND

Pfizer Inc. 235 East 42nd Street 150-3-46New York NY 10017

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Kalamazoo MI 49001-0199

Autoimmunity Research Foundation 3423 Hill Canyon Avenue Thousand Oaks CA 91360

Lundbeck, Inc. Four Parkway North Deerfield IL 60015

Genzyme Corp (Ilex Products, Inc.) 4545 Horizon Hill Blvd.

San Antonio TX 78229-2263

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Jazz Pharmaceuticals, Inc. 3180 Porter Drive Palo Alto CA 94304

Auxilium Pharmaceuticals, Inc.40 Valley Stream Parkway Malvern PA 19335

Effective Pharmaceuticals, Inc. 150 Broadway Suite 1800New York NY 10038

EnVivo Pharmaceuticals, Inc. 480 Arsenal Street Watertown MA 02472

Brugnara, Carlo M.D. The Children's Hospital300 Longwood Avenue, Bader 760

Boston MA 02115

Genta, Inc. Two Connell DriveBerkeley Heights NJ 07922

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Sucampo Pharma Americas, Inc. 4520 East-West Highway Third Floor

Bethesda MD 20814

Allermed Labortories, Inc. 7203 Convoy Court San Diego CA 92111

Integrative Therapeutics, Inc. 825 Challenger Drive Green Bay WI 54311

AR Scientific, Inc. 1100 Orthodox Street Philadelphia PA 19124

AR Scientific, Inc. 1100 Orthodox Street Philadelphia PA 19124

Pharmacontrol Corporation661 Palisade Ave., P.O. Box 931 Englewood Cliffs NJ 07632

Auxilium Pharmaceuticals, Inc.40 Valley Stream Parkway Malvern PA 19355

OXiGENE, Inc. 230 Third Avenue Waltham MA 02451

OXiGENE, Inc 321 Arsenal Street Watertown MA 02472

Xenova Biomedix Limited 957 Budkingham Avenue Slough UNITED KINGDOM

Jarrow Formulas, Inc. 1824 S. Robertson Blvd.Los Angeles CA 90035-4317

Cognetix, Inc. 421 Wakara Way Salt Lake City UT 84108

OncoVista, Inc. 14785 Omicron Drive San Antonio TX 78245

Neurobiological Technologies, Inc. 1387 Marina Way South Richmond CA 94804

Drossapharm LTD 4002 Basel SWITZERLAND

Viralytics Limited P. O. Box 1045 Pymble Business Centre AUSTRALIA

Avicena Group, Inc. 228 Hamilton Avenue Palo Alto CA 94301

Avicena Group, Inc. 580 California St. Suite 1600

San Francisco CA 94104

University of California, San Diego

Aroian Laboratory, Div. of Biological Sciences Department 0322

LaJolla CA 92093-0322

ImmuCell Corporation 56 Evergreen Drive Portland ME 04103

Duke University Medical CenterDivision of Pediatric Allergy & Immunology Erwin Road

Durham NC 27710

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Lux Biosciences, Inc.Hoarborside Financial Center Plaza 10, 14th Floor

Jersey City NJ 07302

Maas Biolab,LLCTecnology Ventures Corporation Technopolis 1155 University Blvd., SE

Albuquerque NM 87106

Sigmoid Pharma Limited Dublin City University IRELAND

Sigmoid Pharma Limited Dublin City University IRELAND

APT Pharmaceuticals, Inc. 700 Airport Blvd. Suite 350Burlingame CA 94010

APT Pharmaceuticals, Inc. 700 Airport Blvd. Suite 350Burlingame CA 94010

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92623-9534

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534Irvine CA 92623-9534

NOVAGALI Pharma SA Batiment Genavenir IV F-91058-Evry cedex FRANCE

Novagali Pharma S.A. 1 rue Pierre Fontaine 91058 Evry cedex FRANCE

Novagali Pharma S.A. 1 rue Pierre Fontaine 91058 Evry cedex FRANCE

Lux Biosciences, Inc.Harborside Financial Center Plaza 10, 14th Floor

Jersey City NJ 07302

RTP Pharma Corporation200 Westpark Corporate Center 4364 South Alston Avenue

Durham NC 27713-2280

University Of GeorgiaCollege Of Veterinary Medicine

Department of Small Animal Medicine

Athens GA 30602

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Adherex Technologies, Inc. 4620 Creekstone Drive Durham NC 27703

Bennu Pharmaceuticals, Inc. (dual EMEA) 9 Commercial Blvd. Novato CA 94949

Bennu Pharmaceuticals 9 Commerical Blvd Novato CA 94949

Thoene, Jess G., M.D.University of Michigan Medical School 300 NIB, 1192 SE

Ann Arbor MI 48109-0408

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Genzyme Corporation One Mountain Rd. P.O. Box 9322

Framingham MA 01701-9322

GenVec, Inc. 12111 Parklawn Drive Rockville MD 20852

Genzyme Corporation One Mountain Road P.O. Box 9322

Framingham MA 01701-9322

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

Bruce Frankel, MDMedical University of South Carolina

96 Jonathan Lucas Street, Suite 428 CSB

Charleston SC 29425

Celator Pharmaceuticals, Inc. 303 B College Road East Princeton NJ 08540

Vical Inc.10390 Pacific Center Court San Diego CA 92121

Vical Incorporated10390 Pacific Center Court San Diego CA 92121

Bayer CorporationPharmaceutical Division, Biological Products 400 Morgan Lane

New Haven CT 06516

Norwich Eaton Pharmaceuticals P.O. Box 191 Norwich NY 13815

Jacobus Pharmaceutical Company, Inc. 37 Cleveland Lane P.O. Box 5290

Princeton NJ 08540

Jacobus Pharmaceutical Company 37 Cleveland Lane P.O. Box 5290

Princeton NJ 08540

Jacobus Pharmaceutical Company 37 Cleveland Lane P.O. Box 5290

Princeton NJ 08540

Diatos USA, LLC 15310 Amberly Drive Tampa FL 33647

Helsinn Healthcare SAVia Pian Scairolo, 6912 Pazzallo Lugano SWITZERLAND

MediWound, Ltd. 3, Azrieli Center Tel-Aviv 67023 ISRAEL

Eisai Medical Research, Inc. 6611 Tributary Street Baltimore MD 21224-6515

Eisai Medical Research, Inc. 6611 Tributary Street Baltimore MD 21224-6515

Eisai Medical Research, Inc. 6611 Tributary Street Suite 200Baltimore MD 21224-6515

ApoPharma, Inc. 200 Barmac Drive CANADA

ApoPharma, Inc. A Division of Apotex Research Inc. Toronto, Canada M9L 1T9 CANADA

Biomedical Frontiers, Inc. 1095 10th Avenue, SE Minneapolis MN 55414

Gentium SpA Piazza XX Settembre, 2 ITALY

Gentium SpA Piazza XX Settembre, 2 22079 Villa Guardia (CO) ITALY

Crinos International Via Belvedere 1 Villa Guardia, Italy 22079

Genelabs Technologies, Inc. 505 Penobscot Drive Redwood City CA 94063

Paladin Labs, Inc.6111 Royalmount Avenue, Suite 102 Montreal

Quebec H4P 2T4 CANADA

Pharmadigm, Inc. 2401 Foothill DriveSalt Lake City UT 84109-1405

Pharmadigm, Inc. 2401 Foothill DriveSalt Lake City UT 84109-1405

Roberts Pharmaceutical Corp. Meridian Center II Four Industrial Way WestEatontown NJ 07724-2274

Peptimmune, Inc. 64 Sidney StreetCambridge MA 02139-4170

Allergan 2525 Dupont Drive P. O. Box 19534Irvine CA 92623-9534

EyeGate Phardmaceuticals, Inc. 100 Beaver Street Waltham MA 02453

Pharmos Corporation 99 Wood Avenue Suite 311Iselin NJ 08830

BCY LifeSciences Inc. 160 Eglinton Ave. East Suite 600

Toronto, Ontario M4P 3B CANADA

Holles Laboratories, Inc. 30 Forest Notch Cohasset MA 02025

Biomedical Frontiers, Inc. 1095 10th Avenue S.E. Minneapolis MN 55414

Kennedy & Hoidal, M.D.'sUniversity Of Utah Medical Center

50 North Medical Drive, Room 4R240

Salt Lake City UT 84132

Ueno Fine Chemicals Industry, Ltd.

2-31 Koraibashi, Higashi-ku Osaka 541 JAPAN

Luitpold Pharmaceuticals, Inc..Clinical Research & Development 800 Adams Avenue

Valley Forge PA 19403

Luitpold Pharmaceuticals, Inc. 800 Adams Avenue 1st FloorValley Forge PA 19403

Luitpold Pharmaceuticals, Inc..Clinical Research and Development 800 Adams Avenue

Valley Forge PA 19403

Baxter Healthcare Corporation 1620 Waukegan Road McGaw Park IL 60085

Warner-Lambert Company2800 Plymouth Rd., P.O. Box 1047 Ann Arbor MI 48106

Bristol-Myers Squibb2400 West Lloyd Expressway Evansville IN 47721

Connaught Laboratories Route 611, P.O. Box 187 Swiftwater PA 18370

CIS-US 10 DeAngelo Drive Bedford MA 01730

Genzyme Corporation 153 Second Avenue Waltham MA 02451

Allertein Therapeutics, LLC 640 Sasco Hill Road Fairfield CT 06824

Sirion Therapeutics, Inc.9314 E. Broadway Avenue Tampa FL 33619

Bette S. Pollard, LLC 11008 Lamplighter Lane Potomac MD 20854

PrimeCyte, Inc. 130 Fifth Ave., N. Seattle WA 98109-4933

PrimeCyte, Inc. 130 Fifth Ave., N. Seattle WA 98109-4933

Boehringer Mannheim Corp. 1301 Piccard Drive Rockville MD 20850

Sigma-Tau Research, Inc. 9841 Washingtonian Blvd Suite 502Gaithersburg MD 20878

Besins Internaitonal, US Inc. 610 Herndon Parkway Suite 750Herndon VA 20170

Abela Pharmaceuticals, Inc. 21581 Midcrest Drive Lake Forest CA 92630

Abela Pharmaceuticals, Inc. 21581 Midcrest Drive Lake Forest CA 92630

Research Industries Corp.

Cancer Technologies, Inc. 7301 East 22nd Street Suite 10ETucson AZ 85710

Cancer Technologies, Inc. 7301 East 22nd Street Suite 10ETucson AZ 85710

Forum Products, Inc. 33 Flying Point Road Southampton NY 11968

Lloyd E. King, Jr. 1900 Patterson Street Suite 104Nashville TN 37203

ImmunoTherapeutics, Inc. 3505 Riverview Circle Moorhead MN 56560

Discovery Experimental & Development, Inc. 29949 S.R. 54 West Wesley Chapel FL 33543

Anthra Pharmaceuticals, Inc.103 Carnegie Center, Suite 102 Princeton NJ 08540

Pharmaquest Corporation 4470 Redwood Highway San Rafael CA 94903

DNage B.V. Darwinweg 24 NETHERLANDS

DuPont Pharmaceuticals Company Chestnut Run, Maple Run Centre Rd.

Wilmington DE 19805

Expression Genetics, Inc. 2215 Mock Road Huntsville AL 35801

Vical Incorporated 9373 Towne Center Dr. Suite 100

San Diego CA 92121-3088

AVAX Technologies, Inc.9200 Indian Creek Parkway Building 9, Suite 200

Overland Park KS 66210

Luitpold Pharmaceuticals, Inc. 800 Adams Avenue 1st FloorValley Forge PA 19403

Johnson & Johnson Pharmaceutical Research & Dev. 920 US Highway 202 P. O. Box 300

Raritan NJ 08869

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Supratek Pharma Inc. 215Bouchard Blvd DorvalQuebec H9S 1A9 CANADA

BioAlliance Pharma59, Bd Gal Martial Valin - 75015 Paris FRANCE

Supratek Pharma, Inc. 215 Bouchard Blvd Dorval, Quebec H9S 1A9 CANADA

Demegen, Inc. 100 Technology Drive Suite 440 BPittsburgh PA 15219

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming H4S 2C8 Montreal CANADA

Chelsea Therapeutics, Inc.13950 Ballantyne Corporate Place Charlotte NC 28277

Lantibio, Inc. 100 Europa Drive Suite 421Chapel Hill NC 27517

Mayo Foundation200 First Street Southwest Rochester MN 55905

Mayo Foundation200 First Street Southwest Rochester MN 55905

Dyax Corp 300 Technology Square Cambridge MA 02139

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Novartis Pharmaceuticals Corp.59 Route 10/Bldg 122/N142 One Health Plaza

East Hanover NJ 07936-1080

Allos Therapeutics, Inc. 11080 CirclePoint Road Suite 200Westminster CO 80020

VBL Pharmaceuticals, Inc. 216 Robin Way Menlo Park CA 94025

Marion Merrell Dow, Inc. P.O. Box 9627 Kansas City MO 64134

Innapharma, Inc. 10 Mountainview RoadUpper Saddle River NJ 07458

Warner-Lambert Company

Parke-Davis Pharmaceutical Research Division 2800 Plymouth Road

Ann Arbor MI 48105

VivoRx 2825 Santa Monica Blvd. 2nd Floor

Santa Monica CA 90404-2429

Adherex Technologies, Inc. 4620 Creekstone Drive Research Triangle Park Durham NC 27703

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

Raptor Therapeutics, Inc. 9 Commercial Boulevard Suite 200Novato CA 94949-6118

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Chiron Vision 500 Iolab Drive Claremont CA 91711

Ethicon, Inc. P.O. Box 151 Somerville NJ 08876

Johnson & Johnson Pharmaceutical Research & Dev., 920 U.S. Highway Route 202, P.O. Box 300

Raritan NJ 08869-0602

R. W. Johnson Pharmaceutical Research Institute Route 202 South P.O. Box 300

Raritan NJ 08869

Ortho Biotech Oncology Research & Development

Pharmaceutical R & D, LLC 920 US Highway 202

Raritan NJ 08869-0602

R. W. Johnson Pharmaceutical Research Institute Route 202, P.O. Box 300 Raritan NJ 08869

Chugai-USA, Inc. 3780 Hawthorn Court Waukegan IL 60087

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Upjohn Company 301 Henrietta Street Kalamazoo MI 49001

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Neurochem, Inc.7220 Frederick Banting, Suite 100 Saint-Laurent

Quebec H4S 2A1 CANADA

Center for Cell and Gene Therapy Feigin Center Suite 1120

Houston TX 77030-2399

Genentech, Inc 1 DNA WaySouth San Francisco CA 94080-4990

EUSA Pharma (US), Inc. 1980 South Easton Road Suite 250Doylestown PA 18901

Lyphomed, Inc.

Organon Teknika Corporation

McDonnell Douglas CorpP.O. Box 516, 107/2 MS10 St. Louis MO 63166

Ascend Therapeutics, Inc. 607 Herndon Parkway Suite 110Herndon VA 21070

Immunex Corporation 51 University Street Seattle WA 98101-2936

OrfagenParc Technologique du Canal

31521 Ramonville Saint Agne Cedex FRANCE

OrfagenParc Technologique du Canal

31521 Ramonville Saint Agne Cedex FRANCE

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

U.S. Bioscience 100 Front StreetWest Conshohocken PA 19428

Laxdale Ltd.Kings Park House, Laurelhill Business Park

Polmaise Road, Stirling FK7 9JQ UNITED KINGDOM

MGI Pharma, Inc.6300 West Old Shakoppe Rd. Suite 110

Bloomington MN 55438-2318

MGI Pharma, Inc.6300 West Old Shakoppe Rd. Suite 110

Bloomington MN 55438-2318

SuperGen, Inc.Two Annabel Lane, Suite 220 San Ramon CA 94583

SuperGen, Inc.Two Annabel Lane, Suite 220 Suite 10

San Ramon CA 94583

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Osiris Therpeutics, Inc. 2001 Aliceanna Street Baltimore MD 21231-3043

OSI Pharmaceuticals, Inc. 58 South Service Road Suite 110Melville NY 11747

Novo Nordisk Pharmaceuticals, INc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

CSL Behring L.L.C. 1020 First Ave. PO Box 61501

King of Prussia PA 19406-0901

Zymogenetics, Inc. 4225 Roosevelt Way Seattle WA 98105

Acorda Therapeutics 15 Skyline Dr. Hawthorne NY 10532

Acorda Therapeutics, Inc. 15 Skyline Dr. Hawthorne NY 10532

Neuropharm, Ltd. Fetcham Park HouseLeatherhead, Surrey KT22 9HD UNITED KINGDOM

Cancer Research UK 61 Lincoln's Inn Fields London WC2A 3PX UNITED KINGDOM

USC-CHLA Institute for Pediatric Clinical Research

Childrens Hospital Los Angeles 4650 Sunset Blve, MS 55

Los Angeles CA 90027

Degussa AG Weissfrauenstr.9 D-60287 Frankfurt GERMANY

Oclassen Pharmaceuticals, Inc. 100 Pelican Way San Rafael CA 94901

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Melville Biologics, Inc. 310 East 67th Street New York NY 10021

Chiron Vision 9342 Jeronimo Road Irvine CA 92718

Amgen, Inc. 1840 Dehavilland Drive Thousand Oaks CA 91320

Amgen, Inc. One Amgen Center Dr.Thousand Oaks CA 91320-1799

Franco Muggia, M.D. 160 East 34th Street New York NY 10016

Berlex Laboratories, Inc. 15049 San Pablo Avenue P.O. Box 4099Richmond CA 94804-0099

Farmacon, Inc. Post House, Suite 213 1720 Post Road EastWestport CT 06880-5643

Janssen Research Foundation P.O. Box 200Titusville NJ 08560

Lederle LaboratoriesDivision of American Cyanamid Company 401 N. Middletown Road

Pearl River NY 10965

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Ethypharm SA194 Bureaux de la Colline - Batiment D 92213 Saint-Cloud Cedex

Neuropharm, Ltd. Felcham Park House Lower Road, Leatherhead UNITED KINGDOM

Hollander, Eric MDThe Mount Sinai School of Medicine One Gustave L. Levy Place

New York NY 10029-6574

Gilead Sciences, Ince. 2025 First Avenue Seattle WA 98121

Questcor Pharmaceuticals, Inc. 3260 Whipple Road Union City CA 94587-1217

The Cure Our Children Foundation 1730 Michael Lane

Pacific Palisades CA 90272-2037

Centocor, Inc.200 Great Vallley Parkway Malvern PA 19355-1307

Topo Target A/S Symbion Science Park Fruebjergvej 3 DENMARK

Receptor BioLogix, Inc. 1140 Veterans Blvd. Suite A

South San Francisco CA 94080

Receptor BioLogix, Inc. 1140 Veterans Blvd. Suite A

South San Francisco CA 94080

Warner-Lambert Company

Parke-Davis Pharmaceutical Research Division 2800 Plymouth Road

Ann Arbor MI 48105

Biocraft Laboratories, Inc. 18-01 River Road Fair Lawn NJ 07410

Sigma Chemical Company

Zurier, Robert B. M.D.

University of Massachusetts Medical Center 55 Lake Avenue

Worcester MA 01655

Marinus Pharmaceuticals, Inc. 21 Business Park Drive Branford CT 06405

Sirion Therapeutics, Inc.9314 East Broadway Avenue Tampa FL 33619

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Research Triangle Park NC 27709

Fidia Pharmaceutical Corp.1401 Eye Street, N.W. Suite 900 Washington DC 20005

Amgen One Amgen Center Drive Mail Stop 17-2-A

Thousand Oaks CA 91320-1799

Memgen, LLC 7557 Rambler Road Dallas TX 75231

Ark Therapeutics Ltd. 1 Fitzroy Mews London UNITED KINGDOM

MediGene, Inc.10650 Scripps Ranch Blvd. Suite 230

San Diego CA 92131

ProcesScience, Inc (PSI) 117 Woodberry Lane Fayetteville NY 13066

Lipha Pharmaceuticals, Inc. 9 West 57th Street Suite 3825New York NY 10019-2701

Liposome Company, Inc. One Research Way Princeton NJ 08540

Teva Neurosciences, Inc. P. O. Box 1005 Horsham PA 19044-8005

TEVA Pharmaceuticals, USA 1090 Horsham Road North Wales PA 19454

Protherics, Inc.5214 Maryland Way, Suite 405 Brentwood TN 37027

Threshold Pharmaceuticals, Inc. 1300 Seaport Blvd. Redwood City CA 94063

ProtAffin Biotechnologie AGImpulszentrum Graz - West A-8020 Graz AUSTRIA

Chugai Pharmaceutical Co., Ltd.

Ucyclyd Pharma, Inc

Subsidiary of Medicis Pharmaceutical Corporation 8125 N. Hayden Rd.

Scottsdale AZ 85258

Hyperion Therapeutics, Inc. 601 Gateway Blvd. Suite 200

South San Francisco CA 94080

Moser, Hugo W. M.D. Johns Hopkins UniversityKennedy Krieger Institute, 707 North Broadway

Baltimore MD 21205

Sciele Pharma, Inc. Five Concourse Parkway Suite 1800Atlanta GA 30328

GlycoMimetics, Inc. 101 Orchard Ridge Drive Gaithersburg MD 20878

Gradalis, Inc. 2545 Golden Bear Drive Carrollton TX 75006

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Reidenberg, Marcus M. M.D.The New York Hospital - Cornell Medical Center

525 East 68th Street, Box 70

New York NY 10021

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

DrugRecure Aps Scion DTU Boge alle 5, 1,tv DENMARK

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

Valeant Pharmaceuticals International One Enterprise Way Aliso Viejo CA 92656

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

Watson Laboratories, Inc. 311 Bonnie Circle PO Box 1900Corona CA 91718-1900

Bristol-Myers Squibb Pharmaceutical Research Institute 5 Research Parkway P.O. Box 5100

Wallingford CT 06492-7660

Collgard Biopharmaceuticals Ltd.

Textile House, 2 Koifman St. Tel-Aviv 68012 ISRAEL

Cadila Pharmaceuticals Limited, Inc. 9801 Washingtonian Blvd Suite 220

Gaithersburg MD 20878

CPL, Inc.16020 Swingley Ridge Road Suite 145

Chesterfield MO 63017

Orphan Europe Immeuble Le Guillaumet 92046 Paris La Defense FRANCE

Orphan Europe Immeuble Le Guillaumet70 avenue du General de Gaulle,

92056 Paris La Defense FRANCE

Bonkovsky, Herbert L. M.D.

University Of Massachusetts Medical Center 55 Lake Avenue North

Worcester MA 01655

Apex Bioscience, Inc. 109 Conner Drive `Chapel Hill NC 27514

Vectura Group, Inc. 1 Prospect West Wiltshire SN14 6FH UNITED KINGDOM

Ockham Biotech Limited Manor Farm 98 Swanwick Lane UNITED KINGDOM

Trillium Therapeutics, Inc. 96 Skyway Avenue M9W 4Y4 CANADA

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd., NW Boca Raton FL 33487

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd, NW Boca Raton FL 33487

Cubist Pharmaceuticals 65 Hayden Avnue Lexington MA 02421

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

EpiCept Corporation777 Old Saw Mill River Road Tarrytown NY 10591

EpiCept Corporation777 Old Saw Mill River Road Tarrytown NY 10591

Anderson, Karl E., M.D.

University of Texas Medical Branch at Galveston

Route J-09, 700 The Strand

Galveston TX 77550

Hemacare Corporation 4954 Van Nuys Boulevard Sherman Oaks CA 91403

Vical Incorporated9373 Towne Centre Dr., Suite 100 San Diego CA 92121

American BioScience, Inc. 2730 Wilshire Blvd. #110 Santa Monica CA 90403

Rhone-Poulenc Rorer Pharm. 500 Arcola Road Collegeville PA 19426

Gliknik, Inc. 801 W. Baltimore Street Baltimore MD 21201

StressGen Biotechnologies, Inc. is now Nventa

Nventa Biopharmaceuticals Corporation 6055 Lusk Boulevard

San Diego CA 19426-2655

PDL BioPharma, Inc. 34801 Campus Drive Fremont CA 94555

Pharming/Genzyme LLC c/o Genzyme Corporation 1 Mountain Rd.

Framingham MA 01701-9322

Falk Center for Molecular Therapeutics 1801 Maple Avenue Suite 4300

Evanston IL 60201

Medarex, Inc. 519 Route 173 West Bloomsbury NJ 08804

Genmab A/S Tolbodgade 33 DK-1253 Copenhagen K DENMARK

BioInvent International AB Solvegatan 41 SWEDEN

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Genzyme Corporation One Kendall Square Cambridge MA 02139

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Bone Therapeutics S.A. 8, rue Adrienne Bolland BELGIUM

Laboratoire francais du Fractionnement et des Biot 3 Avenue des Tropiques 91985 Courtaboeuf Cedex FRANCE

Biotest Diagnostics Corporation 66 Ford Road Denville NJ 07834

Bio Products Laboratory Dagger Lane Hertfordshire, WD6 3BX UNITED KINGDOM

Protein Therapeutics, Inc. 70 Calle Encanto Tucson AZ 85716

Protein Therapeutics, Inc. 70 Calle Encanto Tucson AZ 85716

Protein Therapeutics, Inc. 70 Calle Encanto Tuscon AZ 85716

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

Pharmalink AB P. O. Box 625 SWEDEN

NABI5800 Park of Commerce Blvd., NW Boca Raton FL 33487

NABI5800 Park of Commerce Blvd., N.W. Boca Raton FL 33487

NABI5800 Park of Commerce Blvd., NW Boca Raton FL 33487

Medarex, Inc. 519 Route 173 West Bloomsbury NJ 08804

Bristol-Myers Squibb Pharmaceutical Research Insti 5 Research Parkway

Signature 91 Bldg/3SIG-3012

Wallingford CT 06492

IRX Therapeutics, Inc. 140 West 57th Street New York City NY 10019

CuraGen Corporation 322 East Main Street Branford CT 06405

Kenta Biotech Limited Rehhagstrsase SWITZERLAND

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Centocor, Inc. 200 Great Valley PArkway Malvern PA 19355-1307

Octapharma USA, Inc. 121 River Street 12th FloorHoboken NJ 07030

Octapharma USA, Inc. 121 River Street 12th FloorHoboken NJ 07030

Enobia Pharma, Inc. 2901 Rachel Street East Montreal, QC H1W 4A4 CANADA

GemVax A/S Drammensveien 100 0273 Oslo NORWAY

MicroGeneSys, Inc. 1000 Research Parkway Meriden CT 06450

Centocor, Inc 200 Great Valley Parkway Malvern PA 19355-1307

MedImmune, Inc. 35 West Watkins Mill Rd. Gaithersburg MD 20878

MacroGenics, Inc. 1500 East Gude Drive Rockville MD 20850

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Biotransplant, Inc. Building 75, 3rd. Ave. Charlestown Navy YardCharlestown MA 02129

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Selexys Pharmaceuticals Corp. 800 Research Parkway Suite 338Oklahoma OK 73104

Biogen IdecInc. 3030 Callan Rd. San Diego CA 92121

Teijin America, Inc. 600 Alexander Park Suite 304Princeton NJ 08540

Morphotek, Inc. 210 Welsh Pool Road Exton PA 19341

Stromedix, Inc. One Canal Park Cambridge MA 02141

CoTherix 5000 Shoreline Court Suite 101

South San Francisco CA 94080

Barbeau Pharma, Inc. 790 W. Frontage Road Suite 125Northfield IL 60093

DuoCort ABKullagatan 8-10, S-252 20 Helsingborg SWEDEN

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Hall, Alan H., M.D. Mile 5.0 Pass Creek Road PO Box 24Elk Mountain WY 82324

UPM Pharmaceuticals, Inc. 6200 Seaforth Street Baltimore MD 21224

Nexell Therapeutics2751 Centerville Rd., Suite 210 Wilmington DE 19808

Nexell Therapeutics, Inc.2751 Centerville Rd., Suite 210 Wilmington DE 19808

TransMolecular, Inc. 840 Memorial Drive Second FloorCambridge MA 02139

GlaxoSmithKline PO Box 13398 Five Moore Drive

Research Triangle Park NC 27709-3398

Farmacon-IL, LLC 1720 Post Road East Suite 213Westport CT 06880-5643

Jerini AG Invalidenstr, 130 10115 Berlin GERMANY

Jerini AG A subsidiary of Shire PLC Invalidenstr. 130 GERMANY

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Kalamazoo MI 49001-0199

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Kalamazoo MI 49001-0199

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Kalamazoo MI 49001-0199

Santhera Pharmaceuticals Limited Hammerstrasse 47 SWITZERLAND

Santhera Pharaceuticals Limited Hammerstrasse 47 SWITZERLAND

Santhera Pharmaceuticals LLC Hammerstrasse 25 CH-4410 Liestal SWITZERLAND

NeoPharm, Inc.225 East Deerpath, Suite 250 Lake Forest IL 60045

ArmaGen Technologies, Inc. 914 Colorado Ave. Santa Monica CA 90401

Bristol-Myers Squibb Company P.O. Box 4000 Mail Stop D12-02Princeton NJ 08543-4000

Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton NJ 08543

NeoPharm, Inc. 150 Field Drive Suite 195Lake Forest IL 60045

Protox Therapeutics, Inc. 1210-885 West GeorgiaVancouver, British Columbia San Diego CANADA

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

AmpliMed Corporation 4380 N. Campbell Ave. Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

Vital Therapies, Inc. 15222 Avenue of Science Suite CSan Diego CA 92128

OMRIX Biopharmaceuticals, Ltd.

Plasma Fractionation Institute Ramat Gan 52621 ISRAEL

ZLB Bioplasma AG Wankdorfstrasse 10 CH-3000 Bern 22 SWITZERLAND

Baxter Healthcare Corporation, Baxter BioscienceWestlake Village CA 91362

Immuno Clinical Research Corp. 750 Lexington Avenue New York NY 10022

Immuno Clinical Research Corp. 155 East 56th Street New York NY 10022

Immuno Clinical Research Corp.750 Lexington Avenue, 19th Floor New York NY 10022

CSL Behring 1020 First Avenue P.O. Box 61501

King of Prussia PA 19406-0901

Medical Research Laboratories International 2 Tesseneer Drive

Highland Heights KY 41076

Medical Research Laboratories International 2 Tesseneer Drive

Highland Heights KY 41076

ALK Laboratories, Inc. Research Center 27 Village LaneWallingford CT 06492

Therion Biologics Corporation 76 Rogers Street Cambridge MA 02142

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

Hybritech, Inc. 11095 Torreyanna Road San Diego CA 92196

RadioIsotope Therapy of America (RITA) Foundation 9701 Richmond Avenue Houston TX 77042

Centocor, Inc. 200 Great Valley ParkwayMalvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355-1307

Introgen Therapeutics, Inc. 2250 Holcombe BlvdHouston TX 77030

Inhibitex, Inc. 8995 Westside Parkway Suite 150Alpharetta GA 30004

EUSA Pharma 650 College Road East Suite 3100Princeton NJ 08540

Newport Pharmaceuticals897 West Sixteenth Street Newport Beach CA 92663

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07119

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Glaxo Wellcome Inc. 5 Moore DriveResearch Triangle Park NC 27709

Burroughs Wellcome Company 3030 Cornwallis RoadResearch Triangle Pk NC 27709

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Berlex Laboratories, Inc.15049 San Pablo Avenue, P.O. Box 4099 Richmond CA 94804

EMD Serono, Inc. One Technology Place Rockland MA 02370

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

EMD Serono, Inc. One Technology Place Rockland MA 02370

Foundation for Fatal Rare Diseases Herrengasse 21 Furstentum Liechtenstein GERMANY

InterMune, Inc. 3280 Bayshore Boulevard Brisbane CA 94005

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Ernest C.Borden

Center for Cancer Drud Discovery and Development 9500 Euclid Avenue

Clevland OH 44195

Immunex Corporation 51 University Street Seattle WA 98101

Immunex Corporation 51 University Street Seattle WA 98101

Amgen, Inc. One Amgen Center DriveThousand Oaks CA 91320-1799

Amgen, Inc. One Amgen Center DriveThousand Oaks CA 91320-1799

Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road Tarrytown NY 10591

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Immunex Corporation 51 University Street Seattle WA 98101

Sandoz Pharmaceuticals Corp. 59 Route 10 East Hanover NJ 07936

Digestive Care, Inc. 1120 Win Drive Bethlehem PA 18017

GammaCan Ltd. 39 Jerusalem Street ISRAEL

Octapharma USA, Inc. 121 River Street Hoboken NJ 07030

DraxImageDiv. of Draxis Specialty Pharmaceuticals, Inc. Kirkland, Quebec H9H 4J4 CANADA

Molecular Insight Pharmaceuticals 160 Second street Cambridge MA 02142

Brogan Pharmaceuticals, LLC 312 Lacebark Street Schererville IN 46375

Brogan Pharmaceuticals, Inc. 9800 Connecticut Drivec/o Purdue Technology Center

Crown Point IN 46307

David E. Kuhl, M.D.

University of Michigan Medical Center/1500 E. Med.

B1G412 /0028 University Hospital

Ann Arbor MI 48109-0028

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

IBC Pharmaceuticals, L.L.C. 300 American Rd. Morris Plains NJ 07950

Lederle Laboratories DivisionAmerican Cyanamide Company 401 N. Middletown Road

Pearl River NY 10965

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Peregrine Pharmaceuticals, Inc. 14282 Franklin Ave. Tustin CA 92780-7017

Eisai Medical Research, Inc. 55 Challengaer Road Ridgefield Park NJ 07660

Eisai Medical Research, Inc. 55 Challenger Road Rodgefield Park NJ 07660

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Perrine, Susan P., M.D. Boston University Cancer Research CenterBoston MA 02118

Amicus Therapeutics, Inc. 6 Cedar Brook Drive Cranbury NJ 08512

Fairfield Clinical Trials, LLC 200 Steep Hill Road Weston CT 06883

Academic Pharmaceuticals 21 N. Skokie Hwy Lake Bluff IL 60044

Incyte Corporation Experimental Station Bldg E400/6430Wilmington DE 19880

Glovax Co., Ltd.Room 307, Koryo Academytel, 437-3

Ahyun-Dong, Mapo-Gu, Seoul 121-010

Pharmedic Company 28101 Ballard Road Lake Forest IL 60045

Pharmalucence, Inc. 10 DeAngelo Drive Bedford MA 01730

Transcend Therapeutics, Inc.640 Memorial Drive, 3rd Floor West Cambridge MA 02139

Transcend Therapeutics, Inc.640 Memorial Drive, 3rd Floor West Cambridge MA 02139

Watson Laboratories, Inc. 311 Bonnie Circle P.O. Box 1900Corona CA 91718-1900

Frontier Pharmaceutical, Inc. SUNY Farmingdale Conklin HallFarmingdale NY 11735

VSL Pharmaceuticals, Inc. 800 S. Frederick Avenue Gaithersburg MD 20877

VSL Pharmaceuticals, Inc. 800 S. Frederick Ave. Gaithersburg MD 20877

Roxane Laboratories, Inc. P.O. Box 16532 Columbus OH 43216-6532

CepTor Corporation 200 International Circle Hunt Valley MD 21030

Vion Pharmaceuticals, Inc. Four Science Park New Haven CT 06511

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd. Franklin TN 37067

Fromm, Gerhard M.D.University Of Pittsburgh School of Medicine Pittsburgh PA 15261

Osmotica Kft.

Osmotica Kft.

Osmotica Kft.

Lev, Meir M.D.

The City College, City University Of NY Medical Sc

Convent Avenue at 138 Street

New York NY 10031

Brigham and Women's Hospital Channing Laboratory Dept. of MedicineBoston MA 02115

Williams, MD, James W.

Rush-Presbyterian-St. Luke's Medical Ctr., Dept. o

1653 West Congress Parkway

Chicago IL 60612-3833

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Errant Gene Therapeutics, LLC218 North Jefferson Street Suite 300

Chicago IL 60661

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Glaxo Wellcome Research and Development 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709

CEL-SCI Corporation 8229 Boone Blvd. Suite 802Vienna VA 22182

Neuromuscular Adjuncts, Inc. S.U.N.Y. at Stony Brook H.S.C. T18-020

Stony Brook NY 11794-8181

Iolab Pharmaceuticals 500 Iolab Drive Claremont CA 94608

Sigma-Tau Pharmaceuticals, Inc.

9841 Washingtonian Blvd. Suite 500

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite500

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc.

9841 Washingtonian Blvd. Suite 500

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Solvay Pharmaceuticals, Inc. 901 Sawyer Road Marietta GA 30062

Mpex Pharmaceuticals, Inc.11535 Sorrento Valley Road San Diego CA 92121

Emmaus Medical, Inc. 3870 Del Amo Blvd Unit 507Torrance CA 90503-7701

Implicit Bioscience Pty Ltd P. O. Box 2072. Toowong Business Center AUSTRALIA

Barrier Therapeutics, Inc 600 College Road East Princeton NJ 08540

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Protein Design Labs, Inc. 34801 Campus Drive Fremont CA 94555

Genzyme Corporation Metrowest Place P.O. Box 9322

Framingham MA 01701-9322

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Aradigm Corporation 3929 Point Eden Way Hayward CA 94545

Aradigm Corporation 3929 Point Eden Way Hayward CA 94545

Transave, Inc. 11 Deer Park DriveMonmouth Junction NJ 08852-1923

Vernon Knight, M.D.

Baylor College of Medicine, Dept. of Molecular Phy One Baylor Plaza

Houston TX 77030

PARI Pharma GmbH Moosstrasse 3 GERMANY

GP-Pharm SAPol. Ind. Els Vinyets els Fogars n 2, Quinti de Mediona Barcelona SPAIN

MedGenesis Therapeutix, Inc. 730-730 View Street Victoria, BC V8W 3Y7 CANADA

Endorex Corp. 900 North Shore Drive Lake Bluff IL 60044

Endorex Corp. 900 North Shore Drive Lake Bluff IL 60044

The University of Texas M.D. Anderson Cancer Center Unit 038

Houston TX 77030

Bio-Path, Inc.3293 Harrison Blvd., Suite 230 Ogden UT 84403

Liposome Company, Inc. One Research Way Princeton NJ 08540

MedGenesis Therapeutix, Inc. 730-730-View Street Victoria, BC, V8W 3Y7 CANADA

Antigenics Incorporated 3 Forbes Road Lexington MA 02421

Oncothyreon Canada, Inc. 2011-94 St., NW Suite 200 CANADA

Oncothyreon Canada, Inc. 2011 - 94th Street NW 200 Edmonston, AB CANADA

Cell Therapeutics, Inc.201 Elliot Avenue West201 Suite 400

Seattle WA 98119

Spectrum Pharmaceuticals, Inc. 157 Technology Drive Irvine CA 92618

R. W. Johnson Pharmaceutical Research Institute Route 202, P.O. Box 300 Raritan NJ 08869

Interneuron Pharmaceuticals, Inc.

99 Hayden Ave., Suite 200 Lexington MA 02421-7966

Tyson And Associates 12832 Chadron Avenue Hawthorne CA 90250

Nyxis Neurotherapies, Inc. 1801 Maple Avenue Suite 4300Evanston IL 60201

CMS Peptides Patent Holding Company Limited

Unit 2106, 21st Floor, Island Place Tower 510 King's Rd North Point HONG KONG

Discovery Laboratories, Inc 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

Vivendy Therapeutics LTD Peter Merian -Strasse 45 SWITZERLAND

Celsion Corpora tion10220-L Old Columbia Road Columbia MD 21046

Actelion Pharmaceuticals Ltd. Gewerbestrasse 16 SWITZERLAND

Baxter Healthcare Corporation Route 120 & Wilson RoadRound Lake IL 60073-0490

Gliknik, Inc. 801 W. Baltimore Street Baltimore MD 21201

ARIAD Pharmaceuticals, Inc 26 Landsdowne StreetCambridge MA 02139-4234

ActivBiotics, Inc. 110 Hartwell Avenue Lexington MA 02421

Pharmaxis Ltd. 10 Rodborough Rd. NSW 2086 AUSTRALIA

Progen Industries Limited P. O. Box 28 Richlands 4077 AUSTRALIA

ViroPharma Inc. 730 Stockton Drive Exton PA 19341

Multidisciplinary Association for Psychedelic Studies, Inc. 3 Francis St. Belmont MA 02478

Glycomed, Inc 860 Atlantic Avenue Alameda CA 94501

GenStar Therapeutics Corporation 10865 Altman Row Suite 200

San Diego CA 92121-1113

Collipp, Platon J. M.D. 176 Memorial Drive Jesup GA 31545

Targacept, Inc. 200 East First St. Suite 300

Winston-Salem NC 27101-4165

Insmed, Inc.8720 Stony Point Parkway Richmond VA 23235

Cephalon, Inc. 41 Moores Road P. O. Box 4011Frazer PA 19355

Yaupon Therapeutics, Inc. 259 Radnor Chester Road Radnor PA 19087

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

ZaBeCor Pharmaceutical Company, LLC 821 Westview Street Philadelphia PA 19119

Mepha AG 4143 Dornach POSTFASH 137 SWITZERLAND

Mepha AG 4143 Dornach POSTFASH 137 SWITZERLAND

Hoag Memorial Hospital Presbyterian

Hoag Cancer Center Cell Biology Laboratory Building 41

Newport Beach CA 92658

CancerVax Corporation 2110 Rutherford Road Carlsbad CA 92008

Bristol-Myers Squibb Research Inst 5 Research Parkway P. O. Box 5100

Wallingford CT 06492

Ribi ImmunoChem Research, Inc. 533 Old Corvallis Road Hamilton MT 59840

Neurim Pharmaceuticals, Ltd. 8 Hanechoshet St. Tel-Aviv ISRAEL

Sack, Robert, M.D.Oregon Health Sciences University

3181 S.W. Sam Jackson Park Road

Portland OR 97201

CyDex Pharmaceuticals, Inc. 10513 W. 84th Terrace Lenexa KS 66214

Glaxo Wellcome Research and Development 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709

Delcath Systems, Inc. Rockefeller Center New York NY 10020

Delcath Systems, Inc. Rockefeller Center 23rd FloorNew York NY 10020

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Cinergen 146 Medinah Drive Blue Bell PA 19422-3212

GlaxoSmithKline Pharmaceuticals P.O. Box 7929 Philadelphia PA 19101

AstraZeneca Pharmaceuticals 1800 Concord Pike PO Box 15437

Wilmington DE 19850-5437

Shire 725 Chesterbrook Blvd. Wayne PA 19087-5637

Asta Medica , Inc. 890 East St.Tewksbury MA 01876-1496

Genopia USA, Inc. 90 Gold Street, 6N New York NY 10038

Wyeth-Ayerst Laboratories P.O. Box 8299Philadelphia PA 19101-8299

Echo Therapeutics, Ltd. 10 Forge Parkway Franklin MA 02038

Therakos, Inc. 437 Creamery Way Exton PA 19431

Amylin Pharmaceuticals, Inc. 9360 Towne Centre Drive San Diego CA 92121

Amylin Pharmaceuticals, Inc. 9360 Towne Center Drive San Diego CA 92121

Formac Pharmaceuticals, NV Gaston Geenslaan 1 BELGIUM

Galderma Laboratories, Inc. P.O. Box 331329 Fort Worth TX 76163

Searle 4901 Searle Parkway Skokie IL 60077

S.L.A. Pharma (UK) Ltd Elite House Leavesden Watford WD25 7SA UNITED KINGDOM

Aton Pharma, Inc. 3150 Brunswick Place Lawrenceville NJ 08648

Tau Therapeutics, LLC 2988 Cove Trace Charlottesville VA 22911

Tau Therapeutics, LLC 2988 Cove Trace Charlottesville VA 22911

Cav-Con, Inc. 55 Knollwood Road Farmington CT 06032

Thrombotargets Corp. 2530 Meridian Parkway Durham NC 27713

Thrombotargets Corp. 2530 Meridian Parkway Suite 3023Durham NC 27713

Schwarz Biosciences, Inc.8010 Arco Corporate Drive Raleigh NC 27617

Immuno-Designed Molecules 9 Parker Irvine CA 92618-1605

HRA Pharma 15 , rue Beranger 75003 Paris FRANCE

Corcept Therapeutics, Inc. 149 Commonwealth Drive Menlo Park CA 94025

Actelion Pharmaceuticals Ltd Innovation Centre CH-4123, Allschwil SWITZERLAND

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

ExperGen Drug Development GmbH

Hernalser Haupstrasse 24/16 AUSTRIA

Paladin Labs (USA), Inc. 160 Greentree Drive Suite 101Dover DE 19904

Lederle Laboratories DivisionDivision of American Cyanamid Company 401 N. Middletown Road

Pearl River NY 10965

Autoimmunity Research Foundation

Autoimmunity Research, Inc. Thousand Oaks CA 91360

Gynuity Health Projects, LLC 15 East 26th Street New York NY 10010

ILEX Oncology, Inc. 4545 Horizon Hill Blvd.San Antonio TX 78229-2263

Biopharmaceutics, Inc. 990 Station Road Bellport NY 11713

Biopharmaceutics, Inc. 990 Station Road Bellport NY 11713

Mobius Therapeutics, Inc. 743 Spirit 40 Park Drive Chesterfield MO 63005

IOP Inc.3100 Airway Avenue, Suite 106 Costa Mesa CA 92626

Immunomedics, Inc. 300 American Rd. Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Ester Neurosciences Ltd.Ackerstein Towers, Bldg B, 10th Floor 11 HaManoflm St. ISRAEL

IDEC Pharmaceuticals Corporation 3030 Callan Road San Diego CA 92121

IDEC Pharmaceuticals Corporation 11011 Torreyana Road San Diego CA 92121

Centocor, Inc. 244 Great Valley Parkway Malvern PA 19355

United Therapeutics Corporation PO Box 14186 One Park Drive

Research Triangle Park NC 27709

VivoRx Autoimmune, Inc.2825 Santa Monica Blvd., Suite 200 Santa Monica CA 90404

Protein Design Labs, Inc. 2375 Garcia Avenue Mountain View CA 94043

Protein Design Labs, Inc. 2375 Garcia Avenue Mountain View CA 94043

Protein Design Labs, Inc. 34801 Campus Dr. Fremont CA 94555

ViRexx Medical Corporation 8223 Roper Road Edmonton CANADA

Pfizer, Inc. 235 East 42nd Street New York NY 10017

Glaxo Wellcome Inc. 5 Moore Drive PO Box 13398

Research Triangle Park NC 27709

Pharmacyclics, Inc. 999 East Arques Avenue Sunnyvale CA 94085-4521

FeRx Incorporated4330 La Jolla Village Drive Suite #250

San Diego CA 92122

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Astra Pharmaceuticals, L.P. 725 Chesterbrook Blvd. Wayne PA 19087-5677

Peregrine Pharmaceuticals, Inc. 14272 Franklin Ave. Suite 100Tustin CA 92780

Antisoma plc West Africa House Hanger Lane EalingLondon W5 3QR UNITED KINGDOM

Epeius Biotechnologies Corporation 475 Huntington Drive San Marino CA 91108

Epeius Biotechnologies Corporation 475 Huntington Drive San Marino CA 91108

Epeius Biotechnologies Corporation

345 Pioneer Drive, 1803W Glendale CA 91203

Statens Seruminstitut 5 Artillerivej DK-2300 Copenhagen S SWEDEN

Hoffman-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

AutoImmune, Inc. 128 Spring Street Lexington MA 02173

Abbott Nutrition Abbott Laboratories 625 Cleveland Ave.Columbus OH 43215-1724

Orexo AB Box 303 Virdings alle 32 A SWEDEN

AB Science 3, avenue George V FRANCE

Aegerion Pharmaceuticals, Inc. Center Pointe IV Suite 304Bridgewater NJ 08807

Amgen, Inc. One Amgen Center DriveThousand Oaks CA 91320-1799

Vertex Pharmaceuticals, Inc. 130 Waverly St.Cambridge MA 02139-4242

MethylGene 7220 Frederick Banting St. Laurant CANADA

MethylGene 7220 Frederick Banting Quebec H4S 2A1 CANADA

Ambit Biosciences Corporation4215 Sorrento Valley Boulevard San Diego CA 92121

AB Science 3, avenue George V FRANCE

Abbott LaboratoriesPharmaceuticals Products Division D-491, AP30-1E

Abbott Park IL 60064-6157

CytRx Corporation 3030 Bunker Hill Street Suite 101San Diego CA 92109

Abbott LaboratoriesGlobal Pharmaceuticals Research & Development 200 Abbott Park Road

Abbott Park IL 60064-6157

Abbott LaboratoriesGlobal Pharmaceuticals Research & Development 200 Abbott Park Road

Abbott Park IL 60064-6157

Coley Pharmaceuticals Group, Inc. 93 Worcester Street Suite 101

Wellesley MA 02481

Pfizer, Inc. 50 Pequot Avenue 6025-A3106New London CT 06320

NeuroSearch A/S 93 Pederstrupvej DK-2750 Ballerup DENMARK

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd., NW Boca Raton FL 33487

Cook Pharma 109 Graylyn Drive Chapel Hill NC 27516

Galephar Pharmaceutical Research, Inc.

Road 198, No. 100 km. 14.7 Juncos Industrial Park

Juncos 00777-3873 PUERTO RICO

William M. Lee, MD, FACP

University of Texas Southwestern Medical Center at 5323 Harry Hines Blvd

Dallas TX 75390-9151

ExSAR Corporation 11 Deer Park DriveMonmouth Junction NJ 08852

Medco Research, Inc. 8455 Beverly Blvd. Suite 308Los Angeles CA 90048

NAPA of the Bahamas3560 Pennsylvania Avenue, Suite 7 Dubuque IA 52002

Abbott LaboratoriesPharmaceutical Products Division 200 Abbott Park Road

Abbott Park IL 60064

Sequella, Inc.9610 Medical Center Drive Rockville MD 20850

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

WATSON Laboratories, Inc. 33 Ralph Avenue P.O. Box 30Copiaque NY 11726-0030

Centocor, Inc. 200 Great Valley Parkway Malvern PA 19355

Ericsson, Arthur Dale, M.D.6560 Fannin, Scurlock Tower, Suite 720 Houston TX 77303

Ferring Laboratories, Inc.400 Rella Boulevard, Suite 201 Suffern NY 10901

Fleischmann, Jonathan M.D.MetroHealth Medical Center 3395 Scranton Road

Cleveland OH 44109

Valley Fever Center for Excellence (1-111 INF) University of Arizona Tucson AZ 85723

Novartis Pharmaeuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

YM Biosciences Inc. 5045 Orbitor DriveMississauga, Ontario L4W 4Y4 CANADA

Xechem International, Inc. 379 Thornall Street Edison NJ 08837

Romark Laboratories, L.C.6200 Courtney Campbell Causeway Suite 880

Tampa FL 33607

Swedish Orphan AB Kungsgatan 37, 7th Floor SE-111 56 SWEDEN

INO Therapeutics 6 Route 173 Clinton NJ 08809

SensorMedics Corporation22705 Savi Ranch Parkway

Yorba Linda CA 92887-4645

INO Therapeutics 6 Route 173 Clinton NJ 08809

INO Therapeutics, Inc. 54 Old Highway 22 Clinton NJ 08809

Thomas, MD, Jeffrey Evan

Thomas Jefferson University and Wills Neurosensory

834 Walnut Street, Suite 650

Philadelphia PA 19107-5102

Synta Pharmaceuticals Corporation 45 Hartwell Ave. Lexington MA 02421

Pfizer, Inc. La Jolla Laboratories10646 Science Center Drive

San Diego CA 92121

Nuvelo, Inc. Inc. 201 Industrial Road Suite 310San Carlos CA 94070-

Antisoma Research Ltd. Hanger Lane Ealing UNITED KINGDOM

Antisoma Research Ltd. Hanger Lane Ealing, London UNITED KINGDOM

Novazyme Pharmaceuticals, Inc. 800 Research Parkway Suite 200

City OK 73104

Gemin X, Inc. 5 Great Valley Parkway Malvern PA 19355

Gemin X, Inc. 5 Great Valley Parkway Malvern PA 19355

Gemin X Pharmaceuticals US, Inc. 400 Chesterfield Pkwy. Suite 100

Malvern PA 19355

Genta Inc. Two Connell DriveBerkeley Heights NJ 07922

Genta, Inc. Two Connell DriveBerkeley Heights NJ 07922

Genta, Inc, Two Connell DriveBerkeley Heights NJ 07922

Genta, Inc. Two Connell DriveBerkeley Heights NJ 07922

GlaxoSmithKline One Franklin Plaza Phildelphia PA 19101

Implicit Bioscience Pty Ltd P. O. Box 2072 Toowong Business Center AUSTRALIA

Omex International, Inc. 6001 Savoy, Suite 110 Houston TX 77036

ChemGenex Pharmaceuticals, Inc. 3715 Haven Avenue Menlo Park CA 94025

ChemGenex Pharmaceuticals, Inc. 3715 Haven Avenue Menlo Park CA 94025

Research Triangle Pharmaceuticals

4364 South Alston Avenue Durham NC 27713

Pronova Biocare, AS PO Box 420 1327 Lysaker NORWAY

Fresenius Kabi Deutschland GmbH Daimlerstrasse 16 GERMANY

Santhera Pharmaceuticals Limited Hammerstrasse 47 SWITZERLAND

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Cytogen Corporation 600 College Road East Princeton NJ 08540

TRF Technologies, Inc.863 Mitten Road, Suite 101 Burlingame CA 94010

Oxis International, Inc.6040 N. Cutter Circle, Suite 317 Portland OR 97217-3935

Debio Pharm S.A. Rue des Terreaux 17 CH-1000 SWITZERLAND

OxThera, Inc. 13709 Progress Blvd. #17 Alachua FL 32615

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

Savient Pharmaceuticals, Inc.One Tower Center Boulevard, 12th floor East Brunswick NJ 08816

Bio-Technology General Corp.One Tower Center Boulevard, 12 th floor East Brunswick NJ 08816

Bio-Technology General Corp. 70 Wood Avenue South Iselin NJ 08830

DuPont Merck Pharmaceutical Company P.O. Box 80027 Wilmington DE 19880

Cardiome Pharma Corp. 3650 Westbrook Mall Vancouver, B.C. CANADA

Inspire Pharmaceuticals, Inc. 4222 Emperor Blvd. Suite 470Durham NC 27703

Inspire Pharmaceuticals, Inc.4222 Emperor Blvd., Suite 470 Durham NC 27703

MediGene AG Lochhamer Str. 11 GERMANY

Baker Norton Pharmaceuticals, Inc. 4400 Biscayne Boulevard Miami FL 33137

Protherics, Inc. 5214 Maryland Way Suite 405Brentwood TN 37027

Protherics, Inc. 5214 Maryland Way Brentwood TN 37027

Oasmia Pharmaceutical AB Vallongatan Uppsala SWEDEN

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immtech Pharmaceuticsl, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Suite 150Vernon Hills IL 60061

Ziopharm Oncology, Inc.One First Avenue, Parris Building 34 Boston MA 02129

Novartis Pharmaceuticals Corporation One Health Plaza

East Hanover NJ 07936-1080

Marlyn Nutraceuticals, Inc. 14851 N. Scottsdale Rd. Scottsdale AZ 85254

NPS Pharmaceuticals, Inc. 300 Interpace Parkway Parsippany NJ 07054

Office of the Surgeon General Department of the Army 1430 Veteran's DriveFt. Detrick MD 21702

MedImmune, Inc. 35 West Watkins Mill Rd. Gaithersburg MD 20878

Ear Foundation2420 Castillo Street, Suite 100 Santa Barbara CA 93105

Novartis Pharmaceutical Corporation One Health Plaza

East Hanover NJ 07936-1080

National Institute of Mental Health, NIH 49 Convent Dr. MSC4405 Bldg. 49, Room B1EE16

Bethesda MD 20892-4405

Hoffman-La Roche Inc. 340 Kingsland St. Nutley NJ 07110-1199

Hoffman-La Roche Inc. 340 Kingsland St. Nutley NJ 07110-1199

Schering-Plough Corporation 2000 Galloping Hill Road Kenilworth NJ 07933-0530

Chiron Corporation 4560 Horton Street Emeryville CA 94608

Polaris Pharmaceuticals, Inc. A Polaris Group Company Suite 106San Diego CA 92121

Polaris Pharmaceuticals, Inc. A Polaris Group Company 6370 Nancy Ridge DriveSan Diego CA 92121

Amgen, Inc. One Amgen Center Dr.Thousand Oaks CA 91320-1789

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

Aventis Behring L.L.C. 1020 First Avenue PO Box 61501

King of Prussia PA 19406-0901

Fisons Corporation755 Jefferson Rd., P.O. Box 1710 Rochester NY 14603

Heyl Chemisch-Pharmazeutische Fabrik GMBH & Co. KG Goerzallee 253

Fedderal of Republic of Germany GERMANY

TRF Pharma, Inc. 863 Mitten Road Burlingame CA 94010

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

Digna Biotech, S.L.Avenida Carlos III el Noble Pamplona (Navarra) SPAIN

Digna Biotech, S.L.Avenida Carlos III el Noble, 36, 1 Dcha. 31003 SPAIN

Ardana Bioscience Ltd. 38 Melville Street Scotland UNITED KINGDOM

Alliance Pharmaceutical Corp. 3040 Science Park Road San Diego CA 92191

Scios Nova, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Sallee, Floyd R. M.D., Ph.D.Cincinnati Children's Hospital Medical Center 3333 Burnet Ave.

Cincinnati OH 45229-3039

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Biomarin Pharmaceutical 105 Digital Drive Novato CA 94949

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

S.L.A. PharmaUnit 3, Hill Farm Industrial Estate Leavesden, Watford UNITED KINGDOM

Medea Research LaboratoriesPort Jefferson Business Center

200 Wilson Street, Building D-6

Port Jefferson NY 11776

The Cure Our Children Foundation 1730 Michael Lane

Pacific Palisades CA 90272-2037

Isis Pharmaceuticals, Inc. 1896 Rutherford Road Carlsbad CA 92008

Poniard Pharmaceuticals 300 Elliott Avenue West Seattle WA 98119

UCB Pharma, Inc. 1950 Lake Park Drive Smyrna GA 30080

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Research Triangle Park NC 27709

Copernicus Therapeutics, Inc. 11000 Cedar Avenue Cleveland OH 44106

Talecris Biotherapeutics, Inc. 8368 US 70 West Clayton NC 27520

BTG International, Ltd 10 Fleet Place London EC4M 7SB UNITED KINGDOM

BTG International Ltd 10 Fleet Place London EC4M 7SB UNITED KINGDOM

PharmaMar USA, Inc University Park at M.I.T. The Richards Building 64

Cambridge MA 02139-4170

PharmaMar USA, Inc. University Park at M.I.T. The Rishards Building

Cambridge MA 02139-4170

CytRx Corporation 154 Technology Parkway Norcross GA 30092

SynthRx Corporation 4606 Willow Bellaire TX 77401

CytRx Corporation 154 Technology Parkway Norcross GA 30092

CytRx Corporation 154 Technology Parkway Norcross GA 30092

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK BoulevardPhiladelphia PA 19103

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK BoulevardPhiladelphia PA 19103

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK BoulevardPhiladelphia PA 19103

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK BoulevardPhiladelphia PA 19103

Savient Pharmaceuticals, Inc.One Tower Center Boulevard, 14th floor East Brunswick NJ 08816

EnzymeRx, LLC 17 Arcadian Avenue Suite 104Paramus NJ 07652

EnzymeRx, LLC 17 Arcadian Avenue Suite 104Paramus NJ 07652

EnzymeRx, LLC 17 Arcadian Avenue Suite 104Paramus NJ 07652

Oncovir3202 Cleveland Avenue N.W. Washington DC 20008

Oncovir 3203 Cleveland Ave., NWWashington DC 20008-3450

Oncovir 3203 Cleveland Ave., NWWashington DC 20008-3450

Oncovir 3203 Cleveland Ave., NWWashington DC 20008-3450

Capmed USA P.O. Box 14 Bryn Mawr PA 19010

Polyphenon E International, Inc. 655 Third Avenue New York NY 10017

Polynoma LLC11622 El Camino Real #100 San Diego CA 92130

Diacrin/Genzyme LLC One Kendall SquareCambridge MA 02139-1562

Diacrin/Genzyme LLC One Kendall SquareCambridge MA 02139-1562

Diacrin/Genzyme LLC One Kendall SquareCambridge MA 02129-1562

Diacrin/Genzyme LLC One Kendall SquareCambridge MA 02139-1562

Titan Pharmaceuticals, Inc. Post Office Plaza50 Division Street, Suite 503

Somerville NJ 08876

Axcan Scandipharm Inc. 22 Inverness Parkway Birmingham AL 35242

QLT Phototherapeutics, Inc. Lederle Laboratories401 North Middletown Road

Pearl River NY 10965

Boehringer Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road PO Box 368

Ridgefield CT 06877

Boehringer Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road PO Box 368

Ridgefield CT 06877

Schering-Plough Corporation 2000 Galloping Hill Road Kenilwortoh NJ 07033

Willen Drug Company

Framework Therapeutics, LLC 1564 33rd Street, NW Washington DC 20007

The Vaccine Company P. O. Box 93921 Carmel CA 93921

The Vaccine Company P. O. Box 93921 Carmel CA 93921

The Vaccine Company P. O. Box 93921 Carmel CA 93921

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Allos Therapeutics, Inc. 11080 CirclePoint Road Westminster CO 80020

Allos Therapeutics, Inc.11080 Circle Point Road, Suite 200 Westminister CO 80020

Allos Therapeutics, Inc. 11080 CirclePoint Road Suite 200Westminster CO 80020

Boehringer-Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road Ridgefield CT 06877

Cambridge Neuroscience, Inc.1 Kendall Square, Bldg. 700 Cambridge MA 02139

EM Pharmaceuticals, Inc.

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216-6529

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016

Sigma-Tau Pharmaceuticals, Inc. 9841 Washingtonian Blvd Suite 500

Gaithersburg MD 20878

Watson Laboratories, Inc. 311 Bonnie Circle Corona CA 91720

Bausch & Lomb Pharmaceuticals Division8500 Hidden River Parkway

Tampa FL 33637

Pierre Fabre Dermatologie Les-Cauquillous FRANCE

LTT Baio-Pharma Co., LtdResearch & Development Division

2-5-1 Atago, Minato-ku, Tokyo JAPAN

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Biophysica, Inc. 2159 Avenida de la Playa Suite BLa Jolla CA 92037

Immuno Clinical Research Corp.750 Lexington Avenue, 19th Floor New York NY 10022

Immuno Clinical Research Corp.750 Lexington Avenue, 19th Floor New York NY 10022

UCB Pharma, Inc. 1950 Lake Park Drive Smyrna GA 30080

Abbott Laboratories 200 Abbott Park Road Abbott Park IL

Scios Nova, Inc. 2450 Bayshore Parkway Mountain View CA 94043

ImmuneWorks, Inc. 351 West 10th Street Indianapolis IN 46202

Able Laboratories, Inc. 200 Highland Avenue Suite 30Needham MA 02494

AutoImmune, Inc. 128 Spring Street Lexington MA 02421

Cellular Sciences, Inc 84 park Avenue P.O. Box 968Flemington NJ 08822

Lyphomed, Inc.

Zydus Pharmaceuticals, Inc. 210 Carnegie Center Princeton NJ 08540

Ascenta Therapeutics, Inc. 101 Lindenwood Drive Suite 405Malvern PA 19355

Seaside Therapeutics, Inc. 840 Memorial Drive Cambridge MA 02139

Applied Genetic Technologies Corp. 11801 Research Drive Suite D

Alachua FL 32615

Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh PA 15213

Alfacell Corporation 225 Belleville Ave. Bloomfield NJ 07003

OncoImmune, Inc. 4532 Benderton Court Columbus OH 43220

ARIAD Pharmaceuticals, Incx. 26 Landsdowne StreetCambridge MA 02139-4234

Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville MD 20850

Applied Genetic Technologies Corp. 12085 Research Drive Suite 110

Alachua FL 32615

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

Novartis Pharmaceutical Corporation Oncology Business Unit One Health Plaza

East Hanover NJ 07986

Novartis Pharmaceutical Corporation Oncology Business Unit One Health Plaza

East Hanover NJ 07936

Xoma (US) LLC 2910 Seventh Street Berkeley CA 94710

Elusys Therapeutics, Inc. 25 Riverside Drive P.O. Box 102Pine Brook NJ 07058

PharmaOrigin ApS Scion DTU Boge alle 5, 1.tv DENMARK

Alseres Pharmaceuticals, Inc. 85 Main Street Hopkinton MA 01748

Baxter Healthcare Corporation Baxter BioscienceWestlake Village CA 91362

Baxter Healthcare Corporation Baxter BioscienceWestlake Village CA 91362

Henogen S.A.Rue des Professeurs Jenner et Brachet, 12 B-6041-Gosselies BELGIUM

PharmAthene, Inc. One Park Place Suite 450Annapolis MD 21401

Viventia Biotech, Inc. 10 Four Seasons Place Toronto ON M9B 6H7 CANADA

NPS Allelix Corp. 6850 Goreway Dr. Ontario L4V 1V7 CANADA

Arriva Pharmaceuticals, Inc. 1010 Atlantic Avenue Alameda CA 94501

Arriva Pharmaceuticals, Inc. 2020 Challenger Drive Alameda CA 94501

PPL Therapeutics (Scotland) Limited Roslin, Edinburgh EH259PP Scotland UNITED KINGDOM

Arriva Pharmaceuticals, Inc. 1010 Atlantic Avenue Alameda CA 94501

Merrimack Pharmaceuticals, Inc. 101 Binney Street Cambridge MA 02142

Zymenex A/S Roskildevej 12 C DENMARK

Wyeth Pharmaceuticals, Inc. P. O. Box 8299Philadelphia PA 19101-8299

AT III LLC c/o Genzyme Corporation15 Pleasant St. Connector, P.O. Box 9322

Framingham MA 01701

Shire Human Genetic Therapies 700 Main Street Cambridge MA 02139

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

Pharming N.V. Cipalstreet 3 B-2440 Geel BELGIUM

Pharming N.V. Cipalstreet 3 B-2440 Geel BELGIUM

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

CC10 Sweden AB Kornhamnstorg 53 Box 2077 SWEDEN

Syntonix PharmaceuticalsA Subsidiary of Biogen Idec Waltham MA 02451

EntreMed, Inc.9640 Medical Center Drive Rockville MD 20850

EntreMed, Inc.9640 Medical Center Drive Rockville MD 20850

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

CuraGen Corporation 322 East Main Street Branford CT 06405

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02124

Nora Therapeutics, Inc. 2400 Boston Street Baltimore MD 21224

Novazyme Pharmaceuticals, Inc. 800 Research Parkway Suite 200

Oklahoma City OK 73104

SymbioTec GmbH Sciene Park Saar 1 Saarbruecken GERMANY

Pharmacia & Upjohn 7000 Portage RoadKalamazoo MI 49001-0199

Pharmacia & Upjohn 7000 Portage RoadKalamazoo MI 49001-0199

GroPep Pty Ltd. Gate 11, Victoria Dr. Adelaide SA 5000 AUSTRALIA

Cephalon, Inc. 41 Moores Road P. O. Box 4011Frazer PA 19355

Insmed, Inc.8720 Stony Point Parkway Suite 200

Glen Allen VA 23235-

Genetics Institute, Inc. 87 CambridgePark Drive Cambridge MA 02140

Zymo Genetics, Inc1201 Eastlake Avenue East Seattle WA 98102

Amgen Inc. One Amgen Center Dr.Thousand Oaks CA 91320-1799

Lysosomal Acid Lipase, LLCSubsidiary of Kentucky BioProcessing, LLC 3700 Airpark Drive

Owensboro KY 42301

ThromboGenics LtdUnit 14, Bridgecourt Office Park Dublin IRELAND

Adienne S.r.1. 24128 Bergamo 64/B Boseta Street ITALY

Adienne S.r.1.24128 Bergamo, 64/B Broseta Street ITALY

Novartis Pharmaceuticals Corp. One Health PlazaEast Hanover NJ 07936-1080 UNITED KINGDOM

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080

Dyax Corporation 300 Technology Square Cambridge MA 02139

Luitpold Pharmaceuticals, Inc. P. O. Box 9001 One Luitpold DriveShirley NY 11967

Zymenex A/S Roskildevej 12C 3400 Hillerod DENMARK

ZymenexA/S Roskildevej 12C 3400 Hillerod DENMARK

ProRetina Therapeutics, S.L.Centro de Empresas de Pozuelo 28224 Pozuelo de Alarcon SPAIN

Connetics Corporation3400 West Bayshore Road Palo Alto CA 94303

Fovea Pharmaceuticals12 Rue Jean Antoine de Baif Paris FRANCE

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Proteon Therapeutics, Inc. 200 West Street Waltham MA 02451

David T. Woodley, MD and Mei Chen, MD

USC Department of Dermatology, Cancer Research Lab 1303 North Mission Road

Los Angeles CA 90033

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Amgen, Inc. One Amgen Center Dr.Thousand Oaks CA 91320-1799

PEPGEN Corporation 1301 Harbor Bay Parkway Alameda CA 94502

Ipsen Limited 190 Bath Road Berkshire S11 3XE UNITED KINGDOM

Y's Therapeutics, Inc. 1111 Bayhill Drive Suite 405

San Bruno CA 94066-3002

Y's Therapeutics, Inc. 866 Malcolm Road Burlingame CA 94010

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

Amgen, Inc. 3200 Walnut Street Boulder CO 80301

Amgen Inc. 3200 Walnut Street Boulder CO 80301

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Artielle ImmunoTherapeutics, Inc.

9020 SW Washington Square Road Suite 450

Tigard, OR 97223-4332

Aerovance, Inc. 2929 Seventh Street Berkeley CA 94710

Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern PA 19355

Telluride Pharmaceutical Corporation 146 Flanders Drive Hillsborough NJ 08876

AstraZeneca LP 725 Chesterbrook Blvd. Wayne PA 19087-5677

Dompe s.p.a. Via Campo di Pile 67100 - L'Aquila ITALY

Questcor Pharmaceuticals, Inc. 3260 Whipple Road Union City CA 94587-1217

NIH/NIDCRBldg 10/Rm 2N236 - DASS/CC 10 Convent Drive

Bethesda MD 20892

Ception Therapeutics, Inc. 101 Lindenwood Drive Suite 400, Valleybrook IIIMalvern PA 19335

MedImmune, Inc.35 West Watkins Mill Road Gaithersburg MD 20878

Infinity Pharmaceuticals, Inc. 780 Memorial Drive Cambridge MA 02139

AstraZeneca Pharmaceuticals LP P. O. Box 8355 1800 Concord Pike

DE 19803-8355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

AVAX technologies, Inc.9200 Indian Creek Parkway Building 9, Suite 200

Overland Park KS 66210

Genzyme Corporation One Mountain Road P.O. Box 9322

Framingham MA 01701-9322

Abbott Abbott Laboratories, Dept. 389, Bldg. J-45 200 Abbott Park Rd.

Abbott Park IL 60064-6135

AbbottAbbott Laboratories, Dept. 389, Bldg. J-45 200 Abbott Park Rd.

Abbott Park IL 60064-6133

Targeted Genetics Corporation1100 Olive Way, Suite 100 Seattle WA 98101

Insmed Inc. 4851 Lake Brooke Drive Glen Allen VA 23060

ThromboGenics Inc. Unit 14 Walkinstown Avenue Dublin 12 IRELAND

Valeant Pharmaceuticals International 3300 Hyland Avenue Costa Mesa CA 92626

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

Pfizer, Inc. 235 East 42nd Street New York NY 10017

PathoGenesis Corporation 201 Elliott Avenue West Suite 150Seattle WA 98119

Hoechst Marion Roussel, Inc. P.O. Box 9627 Mail Station: H3-M2516

Kansas City MO 64134-0627

Hoechst Marion Roussel , Inc. P.O. Box 9627 Mail Station: H3-M2516

Kansas City MO 64134-0627

Salix Pharmaceuticals, Inc.1700 Perimeter Park Drive Morrisville NC 27560

Sparta Pharmaceuticals, Inc. 111 Rock Road Horsham PA 19044-2310

Rhone-Poulenc Rorer Pharmaceuticals, Inc. 500 Arcola Road PO Box 5096

Collegeville PA 19426-0800

Proctor and Gamble Pharmaceuticals

8700 Mason-Montgomery Road Mason OH 08807

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Genentech, Inc. 1DNA Way MS 241A

South San Francisco CA 94080

AVI BioPharma, Inc. One SW Columbia Street Portland OR 97258

MERCK & Co., Inc. 126 East Lincoln Ave. Rahway NJ 07065

Gloucester Pharmaceuticals, Inc. One Broadway Cambridge MA 02142

Pharmacia & Upjohn 7000 Portage RoadKalamazoo MI 49001-0199

Provectus Pharmaceuticals, Inc. 7327 Oak Ridge Highway Knoxville TN 37931

Byk Gulden Pharmaceuticals Byk-Gulden StraBe 2 78467 Konstanz GERMANY

Altana Pharma 220 Park avenue Florham Park NJ 07932

SuperGen, Inc. 4140 Dublin Blvd. Suite 200Dublin CA 94568

EntreMed Incorporated 9640 Medical Center Dr. Rockville MD 20850

Genopia USA, Inc. 90 Gold Street, 6N New York NY 10038

Concordia Pharmaceuticals, Inc.1550 Sawgrass Corporate Parkway Sunrise FL 33323

Phytopharm plc Corpus Christi House

Godmanchester, Cambridgeshire PE29 2HY UNITED KINGDOM

SmithKline Beecham Pharmaceuticals 1250 S. Collegeville Road

Collegeville PA 19426-0989

Debiovision Inc.666 Sherbrooke Street West, Suite 1400 Montreal, Quebec

Schering Corporation 2000 Galloping Hill Rd. Kenilworth NJ 07033

Chemokine Therapeutics Corporation

190 Agronomy Road (UBC) Suite 405

Vancouver, BC V6T 1Z3 CANADA

Teva Pharmaceuticals USA 650 Cathill Rd. Sellersville PA 18960

Synergen, Inc. 1885 33rd Street Boulder CO 80301

Neotropix, Inc. 351 Phoenixville Pike Malvern PA 19355

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Cell Technology, Inc. 1668 Valtec Lane Boulder CO 80306

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Seattle Genetics, Inc21823 30th Drive, Southeast Bothell WA 98021

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Seattle Genetics, Inc.21823 30th Drive Southeast Bothell WA 98021

Richard I. Breuer, M.D.1000 Central Street, Suite 615 Evanston IL 60201

Richard I. Breuer1000 Central Street, Suite 615 Evanston IL 60201

Synthes (USA) 1690 Russell Road PO Box 1766Paoli PA 19301

MedImmune, LLC One MedImmune Way Gaithersburg 20878

Pfizer Global Research and Development

50 Pequot Avenue 6025-B4137 New London CT 06320

SmithKline Beecham Pharmaceuticals One Franklin Plaza Philadelphia PA 19101

HemaQuest Pharmaceuticals, Inc. 101 Federal Street Boston MA 02110

Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Cambridge MA 02139

Framework Therapeutics, LLc 1564 33rd Street, NW Washington DC 20007

IC-MedTech Corporation 9902 Indian Creek Lane El Cajon CA 92021

Stacpoole, Peter W. M.D., Ph.D. University of Florida P.O. Box 100277Gainesville FL 32610

Stacpoole, Peter W. M.D., Ph.D. University of Florida P.O. Box 100277Gainesville FL 32610

Questcor Pharmaceuticals, Inc. 3260 Whipple Rd. Union City CA 94587-1217

Stacpoole, Peter W. M.D., Ph.D. University Of Florida P.O. Box 100277Gainesville FL 32610

EBD Group 2032 Corte del Nogal Suite 120Carlsbad CA 92011

Questcor Pharmaceuticals, Inc. 3260 Whipple Rd. Union City CA 94587-0700

Neutron Technology Corp.& Neutron R&D Partner

877 Main Street, Suite 402 Boise ID 83702

Theragenics Corporation

Hope Pharmaceuticals, Inc8260 E. Gelding Drive #104 Scottsdale AZ 85260

Hope Pharmaceuticals 8260 East Gelding Drive Scottsdale AZ 85260

Hope Pharmaceuticals 8260 E. Gelding Drive Scottsdale AZ 85260

Aires Pharmaceuticals, Inc. 4690 Executive Drive Suite 150San Diego CA 92121

Hope Pharmaceuticals 8260 E. Gelding Drive Scottsdale AZ 85260

Keystone Pharmaceuticals, Inc. 26072 Merit Circle Laguna Hills CA 92653

Ucyclyd Pharma, Inc. 8125 North Hayden Road Scottsdaale AZ 85258

Tikvah Therapeutics, Inc. 75 5th Street, NW. Atlanta GA 30308

Ucyclyd Pharma, Inc. 8125 N. Hayden Road Scottsdale AZ 85258

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

Cellular Sciences, Inc. 84 Park Avenue P. O. Box 968Flemington NJ 08822

VioQuest Pharmaceuticals, Inc. 180 Mt. Airy Road Suite 102

Basking Ridge NJ 07920

Adherex Technologies, Inc. 4620 Creekstone Drive Suite 200Durham NC 27703

Akorn, Inc. 2500 Millbrook Drive Buffalo Grove IL 60089

Keystone Pharmaceuticals, Inc. 26072 Merit Circle Laguna Hills CA 92653

Solbec Pharmaceuticals Limited P. O. Box 2142 WA 6018 AUSTRALIA

Solbec Pharmaceuticals Limited P. O. Box 2142Osbourne Park, Western Australia 6017 AUSTRALIA

Avant Immunotherapeutics, Inc. 119 Fourth Ave. Needham MA 02494-2725

T Cell Sciences, Inc. 119 Fourth AvenueNeedham Heights MA 02194

Octapharma USA, Inc. 121 River Street 12th FloorHoboken NJ 07030

Ferring Laboratories, Inc.400 Rella Boulevard, Suite 201 Suffern NY 10901

UCB, Inc. 1950 Lake Park Drive Smyrna GA 30080

Genentech, Inc.460 Point San Bruno Boulevard

South San Francisco CA 94080

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200Princeton NJ 08540

Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200Princeton NJ 08540

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Bayer Pharmaceuticals Corp. 400 Morgan Lane New Haven CT 06516

Bristol-Myers Squibb 5 Research Parkway P.O. Box 5100Wallingford CT 06492

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Ocera Therapeutics, Inc. 12651 High Bluff Drive San Diego CA 92130

Rhone-Poulenc Rorer Pharmaceuticals 500 Arcola Road Collegeville PA 19426

Genaera Corporation 5110 Campus DrivePlymouth Meeting PA 19462

National Institutes of Health

Cancer Therapy Evaluation Program/DCTD/NCI Suite 7111

Rockville MD 20852

National Institutes of HealthCancer Therapy Evaluation Program NCI/DCTD

Rockville MD 20852

Sanofi Winthrop, Inc. 9 Great Valley Parkway Malvern PA 19355

Sanofi Winthrop, Inc. 9 Great Valley Parkway Malvern PA 19355

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd, NW Boca Raton FL 33487

Gamida Cell Ltd 5, Nahum Hafzadi St. Jerusalem 95484 ISRAEL

Novatech SAAvenue du Vent des Dames - Z.l. les Paluds 13685 Aubagne FRANCE

Novatech SAAvenue du Vent des Dames - Z.l. les Paluds 13685 Aubagne FRANCE

Biocodex 7, avenue Gallieni 94250 Gentilly FRANCE

Sugen, Inc. 230 East Grand Ave.South San Francisco CA 94080-4811

Sugen, Inc. 230 East Grand Ave.South San Francisco CA 94080-4811

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016-1389

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016-1389

Fuisz Technologies, Ltd. 14555 Avion at Lakeside Chantilly VA 20151

Darby Pharmaceuticals, Inc. 100 Banks AvenueRockville Centre NY 11570

Darby Pharmaceuticals, Inc. 100 Banks AvenueRockville Centre NY 11570

Shire Human Genetic Therapies, Inc. 700 Main Street Cambridge MA 02139

Jacobus Pharmaceutical Company 37 Cleveland Lane P.O. Box 5290

Princeton NJ 08540

Pharmacia-Chiron Partnership 4560 Horton Street Emeryville CA 94608

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

Warner-Lambert Company

Parke-Davis Pharmaceutical Research Division 2800 Plymouth Road

Ann Arbor MI 48105-2430

Merritt, T. Allen M.D. 2516 Stockton Boulevard Sacramento CA 95817

Synsorb Biotech Inc.201, 1204 Kensington Road, N.W. Calgary, Alberta CANADA

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd Nashville TN 37217

Repligen Corporation 41 Seyon Street Waltham MA 02453

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

ChiRhoClin, Inc. 1550 Gallaudet Ave.Silver Spring MD 20905-4176

ChiRhoClin, Inc. 15500 Gallaudet Ave.Silver Spring MD 20905-4176

AGI Dermatics 205 Buffalo Avenue Freeport NY 11520

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Tap Holdings Inc. 2355 Waukegan Road Deerfield IL 60015

Agennix, Inc. 8 Greenway Plaza Houston TX 77046

Agennix, Inc. 8 Greenway Plaza Suite 910Houston TX 77046

Agennix, Inc. Greenway Plaza Suite 910Houston TX 77046

Agennix, Inc. 8 Greenway Plaza Suite 910Houston TX 77046

TEVA Neuroscience, Inc. 425 Privet Road Horsham PA 19044-8005

TEVA Neuroscience P. O. Box 1005 Horsham PA 19044-8005

CytRx Corporation 3030 Bunker Hill Road Suite 101San Diego CA 92109

Bristol-Myers Squibbresearch and Development 5 Research Parkway

Wallingford CT 06492-7660

Nexell Therapeutics Inc. 9 Parker Irvine CA 92618-1605

TransDerm, Inc. 2161 Delaware Aenue Santa Cruz CA 95060

Endocyte, Inc. 1205 Kent Ave. West Lafayette IN 47906

NeoRx Corporation 410 West Harrison Seattle WA 98119-4007

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Theseus Imaging Corporation 124 Mount Auburn Street Suite 200 NorthCambridge MA 02138

Taiho Pharma USA, Inc. 210 Carnegie Center Princeton NJ 08540

Belpharma N.V.67 Winston Churchill Avenue Brussels BELGIUM

Biolitec Pharma Ireland Ltd. United Drug House Dublin IRELAND

Schering-Plough Research Institute 2000 Galloping Hill Road Kenilworth NJ 07033

Schering-Plough Research Institute 2000 Galloping Hill Rd. Kenilworth NJ 07033

Gilead Sciences, Inc. 333 Lakeside Drive Foster city CA 94404

ErgoNex Pharma GmbH Ruetistr. 20 CH-9050 Appenzell SWITZERLAND

Biomeasure, Inc. 27 Maple St. Milford MA 01757-3650

Ferring Laboratories, Inc.400 Rella Boulevard, Suite 201 Suffern NY 10901

Orphan Therapeutics, LLC 3 Werner WayRound Valley Executive Center

Lebanon NJ 08833

Genta, Inc. 200 Connell Drive Berkley Heights NJ 07922

Genta Inc. 200 Connell DriveBerkeley Heights NJ 07922

Watson Laboratories Research Park 417 Wakara WaySalt Lake City UT 84108

Star Pharmaceuticals, Inc. 1990 N.W. 44th Street Pompano Beach FL 33064

Bio-Technology General Corp. 70 Wood Avenue South Iselin NJ 08830

Prestwick Pharmaceuticals, Inc. 1825 K Street, NW Suite 1475Washington DC 20006

Danforth, Jr., MD, Elliot University of Vermont 84 Beartown Rd.Underhill VT 05489

Sanofi-Aventis Pharma 9 Great valley Parkway Malvern PA 19355-1304

Antisense Pharma GmbH Josef-Engert-Str. 9 93053 Regensberg GERMANY

Kuros Biosurgery AG Technoiparkstrasse 1 Zurich SWITZERLAND

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Andrulis Research Corporation11800 Baltimore Avenue, Suite 113 Beltsville MD 20705

Celgene Corporation P.O. Box 4914 7 Powder Horn DriveWarren NJ 07059

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Celgene Corporation P.O. Box 4914 7 Powder Horn DriveWarren NJ 07059

Andrulis Research Corporation11800 Baltimore Avenue, Suite 113 Beltsville MD 20705

Andrulis Research Corporation11800 Baltimore Avenue, Suite 113 Beltsville MD 20705

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Celgene Corporation P.O. Box 4914 7 Powder Horn SriveWarren NJ 07059

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Adienne S.r.l.24128 Bergamo, 64/B Broseta Street Bergamo ITALY

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd San Mateo CA 94404

SciClone Pharmaceuticals, Inc. 950 Tower Lane Suite 900

Foster City CA 94404-2125

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd.San Mateo CA 94404-1593

SciClone Pharmaceuticals, Inc.901 Mariner's Blvd., Suite 205

San Mateo CA 94404-1593

RegeneRx Biopharmaceuticals, Inc. 3 Bethesda Metro Center Suite 700

Bethesda MD 20814

Iolab Pharmaceuticals 500 Iolab Drive Claremont CA 91711

Sanofi-Synthelabo, Inc. 9 Great Valley Parkway PO Box 3026Malvern PA 19355

Valeant Research & Development 3300 Hyland Avenue Costa Mesa CA 92626

Arginox Pharmceuticals, Inc. 120 Constitution Drive Menlo Park CA 94025

Miravant Medical Technologies 336 Bollay Drive Goleta CA 93117

Boehringer Ingelheim Pharmaceuticals, Inc. P. O. Box 368 900 Ridgebury Road

Ridgefield CT 06877

Pharmaceutical Research & Dev. 920 U.S. Highway 202 Raritan NJ 08869

Sanofi-Aventis US, Inc. 11 Great Valley Parkway P. O. Box 3026Malvern PA 19355

Laphal Laboratoires48 Bis, Rue des Belles-Feuilles 75116 Paris FRANCE

Aastrom Biosciences, Inc. Domino's Farms24 Frank Lloyd Wright Drive

Ann Arbor MI 48105

Aastrom Biosciences, Inc. Domino's Farms, Lobby L Ann Arbor MI 48105

OrfagenParc Technologique Du Canal-4

31521 Ramonville Saint Agne FRANCE

Athena Neurosciences, Inc. 800 Gateway BoulevardSouth San Francisco CA 94080

Novartis Pharmaceuticals Corp. Drug Regulatory Affairs One Health Plaza

East Hanover NJ 07936-1080

Axentis Pharma AG 138 Limmatquai CH-8001 Zurich SWITZERLAND

Sterling Winthrop 9 Great Valley Parkway Malvern PA 19355

Biogen IDEC Inc. 3030 Callan Road San Diego CA 92121

Orion Corporation P.O. Box 65 02101 Espoo FINLAND

Chroma Therapeutics Ltd. 93 Milton Park Oxfordshire OX14 4RY UNITED KINGDOM

Johnson & Johnson Pharmaceutical Research & Dev. 920 US Highway 202 P. O. Box 300

Raritan NJ 08869

Ortho Biotech Oncology Research & Development 920 U S Highway 202 Raritan NJ 08869

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Angiogen Pharmaceuticals, Pty. Ltd.

Level 31, ABN AMRO Tower

88 Phillip Street Sydney, N.S.W. 2000 AUSTRALIA

Celtrix Pharmaceuticals, Inc. 3055 Patrick Henry Drive Santa Clara CA 95054

PPL Therapeutics (Scotland) Limited Roslin, Edinburgh EH259PP Scotland UNITED KINGDOM

Genentech, Inc. 1 DNA WaySouth San Francisco CA 94080-4990

Medac GmbH Fehlandtstrasse 3 D-20354 Hamburg GERMANY

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Hannan Ophthalmic Marketing Services, Inc 34 Sherrill Rd. Marshfield MA 02050

Cell Works Inc. 6200 Seaforth Street Baltimore MD 21224-6506

VioQuest Pharmaceuticals, Inc. 180 Mt. Airy Road Basking Ridge NJ 07920

Baylor Research Institute 3330 Live Oak Blvd Dallas TX 75204

Baylor Research InstituteInstitute of Metabolic Disease 3812 Elm Street

Dallas TX 75226

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Debio R.A. Inc.7929 Westpark Drive, Suite 400 Mclean VA 22102

Chembiomed, Ltd. P.O. Box 8050, Station F Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Hemotec Medical Products, Inc. Box 19255 Johnston RI 02919

CustomCare Pharmacy 5710 Hoover Blvd Tampa FL 33634

Structural GenomiX, Inc. (SGX) 10505 Roselle Street San Diego CA 92121

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Kennedy & Hoidal, M.D.'sUniversity of Utah Health Sciences Center

50 North Medical Drive, Room 4R240

Salt Lake City UT 84132-0001

arGentis Pharmaceuticals, LLC 20 South Dudley Street Memphis TN 38139

AB Science 3, avenue GeorgeV 75008 Paris FRANCE

Gel-Tec, Division of Tishcon Corp 30 New York Avenue P. O. Box 331

Westbury NY 11590

Gel-Tec, Division of TISHCON Corporation 30 New York Avenue P.O. Box 331

Westbury NY 11590

Gel-Tec, Division of Tishcon Corp. 30 New York Ave. PO Box 331

Westbury NY 11590

Wilex Biotechnology GmbH Grillparzerstrasse 10B 81675 Munich GERMANY

Vitreo Retinal Techologies, Inc 2 Venture Plaza Irvine CA 92618

Inspire Pharmaceuticals, Inc.4222 Emperor Boulevard, Suite 470 Durham NC 27703

Inspire Pharmaceuticals, Inc.4222 Emperor Boulevard, Suite 470 Durham NC 27703

EMD Serono, Inc. One Technology Place Rockland MA 02370

Chiron Vision 500 Iolab Drive Claremont CA 91711

Asklepion Pharmaceuticals, LLC 5200 Maryland Way Brentwood TN 37027

Novartis Pharmaceuticals Corporation 59 Route 10

East Hanover NJ 07936-1080

Leas Research Products 78 Fallon Drive North Haven CT 06473

Verenta Pharmaceuticals, Inc. 10901 Granada Lane Suite 101Leawood KS 66211

Neuropharm Ltd, Fetcham Park House Surrey KT22 9HD UNITED KINGDOM

Topo Target Germany AG Paul-Ehrlich Str. 42-44 D-60596 Frankfurt am Main GERMANY

AstraZeneca Pharmaceutical LP 1800 Concord PikeWilmington DE 19830-8355

H3 Pharma, Inc.666 Sherbrooke Street West Suite 1400 Montreal, Quebec, CANADA

Debiovision, Inc.666 Sherbrooke Street West Suite 1400

Montreal, Quebec H3A 1E7 CANADA

Debiopharm S.A. 17 rue des Terreaux CH-1000 Lausanne 9 SWITZERLAND

Debiopharm S.A. 17 rue des Terreaux CH-1000 Lausanne 9 SWITZERLAND

H3 Pharma, Inc.666 Sherbrooke Street West, Suite 1400 Montreal, Quebec

Anthera Pharmaceuticals, Inc. 25801 Industrial Blvd. Suite BHayward CA 94545

Cangene Corporation 155 Innovation Drive R3T 5Y3 CANADA

PhiloGene, Inc. 174 Summit Avenue Summit NJ 07901

mondoBIOTECH Europark Austrasse 79

Research Triangle Pharmaceuticals

200 Westpark Corporate Center 4364 South Alston Avenue

Durham NC 27713-2280

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

BioMarin Pharmaceutical Inc. 105 Digital Drive Novato CA 94949

Ovation Pharmaceuticals, Inc. Four Parkway North Deerfield IL 60015

Stuart Pharmaceuticals Division of ICI Americas Wilmington DE 19897

Stuart Pharmaceuticals Division of ICI Americas Wilmington DE 19897

Hana Biosciences, Inc. 7000 Shoreline CourtSouth San Francisco CA 94080

Hana Biosciences, Inc 7000 Shoreline Court Suite 370

South San Francisco CA 94080

ZOR Pharmaceuticals, LLC100-A Eastwood Center Drive Suite 118

Wilmington NC 28403

Meritage Pharma, Inc. 12481 High Bluff Drive Suite 160San Diego CA 92130

Wellstat Therapeutics Corp. 930 Clopper Road Gaithersburg MD 20878

Merck Research Laboratories Merck & Co., Inc. P. O. Box 2000, RY 32-605Rahway NJ 07065-0900

Merck & Co., Inc.P. O. Box 2000, RY 32-605 Rahway NJ 07065-0900

VAXON-Biotech 3-5 impasse Reille FRANCE

Circe Biomedical, Inc. 99 Hayden Ave. Lexington MA 02421-7995

MAT Biopharma 4 rue Pierre Fontaine FRANCE

Immunomedics, Inc. 300 American Rd. Morris Plains NJ 07950

National Cancer Institute, DCTNIH, Executive Plaza North, Room 7-18 Bethesda MD 20892

Kanisa Pharmaceuticals, Inc. 12264 El Camino Real San Diego CA 02130