Core 3.1 - Dartmouth Activities

Core 3.1 - Dartmouth ActivitiesCore 3.1 - Dartmouth Activities

Andrew J. Saykin, Psy.D., ABPP-CN

John D. West, M.S.

Robert M. Roth, Ph.D.

Brain Imaging Laboratory

Dartmouth Medical School / DHMC

NA-MICNational Alliance for Medical Image Computing

http://na-mic.org

Overview

National Alliance for Medical Image Computing http://na-mic.org

Volumetric ROI studies Diffusion tensor imaging

ROI analyses Tractography

Functional magnetic resonance imaging Planned applications Related work Current Collaborations


ROI Volumetric Studies

Manual Tracing and 3D Modeling of ROIs using Slicer

ROIs: Hippocampus Amygdala Entorhinal cortex Caudate nucleus Putamen Nucleus accumbens Thalamus Fornix Mammillary bodies


ROI Volumetric Studies

Illustration of 2D Traces and 3D Models of ROIs


Diffusion Tensor Imaging

FA in Uncinate Fasciculus ROI in Schizophrenia using Slicer

Based on Kubicki et al., 2002


Diffusion Tensor Imaging

Healthy Control

Patient with Schizophrenia

C1 - rostrum and genuC2 - anterior truncusC3 - middle truncusC4 - posterior truncusC5 - isthmus and splenium

[Wang et al. 2005]

Integration of Corpus Callosum Subregion ROIs with Tractography


Functional MRI

Cognitive Task Development and Validation: Probing Frontal-Temporal Circuitry

Primary Tasks:

Working memory Episodic memory Semantic memory

Secondary Tasks (other Circuitry)

Self-reflection Reward Planning


Functional MRI

Prospective Data Collection on 1.5T Magnet: Interim Analysis of Patients with

Schizophrenia and Controls

Controls Patients p (n=8) (n=13)

Age (yrs.) 30.8 (7.1) 36.4 (10.3) NSEduc (yrs.)* 16.9 (2.4) 14.6 (1.9) .05Sex (M,F) 3, 5 9, 3 NSWRAT Reading 111.5 (4.7) 105.0 (10.5) NSCVLT-II Total 1-5 58.4 (6.4) 38.6 (10.4) .001

* matched for parental SES


Functional MRIn-Back Working Memory Task

Performance on the In-Scanner Working Memory (3-back) Task

0-back 1-back 2-back 3-back

% C

orre

ct (

adju

sted

for

gue

ssin

g)

40

50

60

70

80

90

100

ControlsPts with Schizophrenia


Functional MRI – Behavioral Performance

Interim analysis


Functional MRI

FMRI Activation During 3-Back in Schizophrenia

ControlsN = 8

PatientsN = 12

Simple Effects

p = .01Interim analysis


Functional MRI

FMRI Activation During 3-Back in Schizophrenia

Controls > Patients

p = .01

Patients > Controls

Interim analysis


Functional MRIVerbal Encoding/Retrieval Episodic Memory Task


Functional MRI – Behavioral PerformanceVerbal Encoding/Retrieval Episodic Memory Task

Performance on the In-Scanner Recognition Memory Task

New Words WM Old Words LD Old Words

% C

orr

ect

(ad

just

ed

for

gues

sin

g)

60

70

80

90

100


Interim analysis

Reaction Time for Performance on the Recognition Memory Task

New Words WM Old Words LD Old Words

Re

actio

n T

ime

0.8

0.9

1.0

1.1

1.2

1.3

1.4



Functional MRI – Behavioral PerformanceVerbal Encoding/Retrieval Episodic Memory Task

Interim analysis


Functional MRI

FMRI Activation During Continuous Auditory-Verbal Memory (new > old word contrast) in Patients with Schizophrenia

PatientsN = 7 p = .01Interim analysis

Verbal Encoding/Retrieval Episodic Memory Task


Collaborations and Progress

Shape Analysis with UNC Group: Martin Styner, Guido Gerig Hippocampal Shape - Dartmouth Data: SPHARM

Overall Mean Left Mean Right Mean

http://www.na-mic.org/Wiki/index.php/Progress_Report:Shape_Analysis

Skeleton-based subdivision



fMRI in Slicer – fMRIEngine - Wendy Plesniak and Haiying Liu Met Dec. 14th, 2005 to discuss progress and future

improvements to be made Have supplied motor data from two controls to test results

from module and compare with results from SPM2 fMRI tasks – Brigham group

Porting of our tasks to BWH Meeting with Marek Kubicki on Dec. 20th, 2005 to

demonstrate our tasks and how we utilize them Training session at BWH

Tara McHugh visited to get in depth training in Slicer for

tracing structures – Dec. 1st, 2005



Working with Steve Pieper to test 64-bit Linux version of Slicer Worked with Steve Pieper, Gordon Kindlmann, Xiaodong Tao,

and Josh Snyder to convert Dartmouth DTI data to nrrd format and

solve lingering orientation issues DTI Path of Interest – MGH – David Tuch and Josh Snyder

Dartmouth request for tools to help relate DTI fiber tract

pathways to connections in fMRI identified circuits Collaboration to implement DTI Path of Interest Program at

Dartmouth site Successful initial results on NAMIC01 healthy control by both

Josh Snyder at MGH and John West at Dartmouth Plans: integrate functional ROIs derived from fMRI tasks


DTI Path of Interest – Initial Results

Collaboration with David Tuch & Josh Snyder (MGH)

Description – program finds the optimal path between two or

more ROIs using probability statistics

Implementation C-code, Matlab and FSL scripts to generate optimal path Slicer for visualization and tracing of input ROIs Full implementation in Slicer as module is a future project

Initial results from NAMIC01 healthy control



Hippocampal ROI to Ventral Prefrontal ROIUncinate Fasciculus



Receptive Speech Area ROI to Expressive Speech Area ROIArcuate Fasciculus



Hippo ROI to Expressive Speech Area ROIUsing Receptive Speech Area ROI as Guide

Arcuate Fasciculus


Planned Applications & Developments

Integration of fMRI and DTI data, including tractography (see tool “wish list”)

Effective and functional connectivity during cognitive tasks (see tool “wish list”)

Examine structural (ROI, DTI) and functional (fMRI) correlates of symptoms and cognition

Expand use of methods to other populations bipolar disorder, OCD, MCI/AD, MS, TBI, epilepsy, other disorders


Neuroimaging Research Center 3T Magnet


Neuroimaging Research Center 3T Magnet


Brain Imaging Laboratory: People

FACULTY PIs (Psychiatry): • Laura A. Flashman, Ph.D.• Alan I. Green, M.D. • Thomas W. McAllister, M.D. • Brenna C. McDonald, Psy.D. • Robert M. Roth, Ph.D. • Andrew J. Saykin, Psy.D.• Heather A. Wishart, Ph.D.

POST-DOCTORAL FELLOWS:• Howard Cleavinger, Ph.D. (Epilepsy)• Ellen Crouse, Ph.D. (MCI, chemotherapy)• Nancy Koven, Ph.D. (Schizophrenia)• Nadia Paré Ph.D. (MCI, ADNI)• Jo Cara Pendergrass, Ph.D. (Schizophrenia)

KEY TECHNICAL COLLABORATORS: • Konstantinos Arfanakis, Ph.D. (DTI; IIT)• Fillia Makedon , Ph.D. (Computer Science)• James C. Ford, Ph.D. (Computer Science)• Li Shen, Ph.D. (CS, UMASS-Dartmouth)• Jason Moore, Ph.D. (Comp Genetics)

BIL COORDINATOR • Heather Pixley, B.A.

IMAGE ANALYSTS & SYSTEMS ADMIN:• John MacDonald, M.A. • Tara McHugh, M.A. • Paul Wang, B.A. • John West, M.S.

STUDY COORDINATORS: • Mary Hynes, RN (TBI)• Ariel Rosen, B.A. (MS)

NEUROSCIENCE TECHNICIANS:• Carrie Kruck, B.A. (chemotherapy)• Margaret Nordstrom, B.A. (MCI)

RESEARCH MRI TECHNOLOGISTS:• Jorge A. Forero• Alice E. Davison


Dartmouth Brain Imaging Laboratory

December, 2005

Documents

Core 3.1 - Dartmouth Activities