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Core 3.1 - Dartmouth ActivitiesCore 3.1 - Dartmouth Activities
Andrew J. Saykin, Psy.D., ABPP-CN
John D. West, M.S.
Robert M. Roth, Ph.D.
Brain Imaging Laboratory
Dartmouth Medical School / DHMC
NA-MICNational Alliance for Medical Image Computing
http://na-mic.org
Overview
National Alliance for Medical Image Computing http://na-mic.org
Volumetric ROI studies Diffusion tensor imaging
ROI analyses Tractography
Functional magnetic resonance imaging Planned applications Related work Current Collaborations
National Alliance for Medical Image Computing http://na-mic.org
ROI Volumetric Studies
Manual Tracing and 3D Modeling of ROIs using Slicer
ROIs: Hippocampus Amygdala Entorhinal cortex Caudate nucleus Putamen Nucleus accumbens Thalamus Fornix Mammillary bodies
National Alliance for Medical Image Computing http://na-mic.org
ROI Volumetric Studies
Illustration of 2D Traces and 3D Models of ROIs
National Alliance for Medical Image Computing http://na-mic.org
Diffusion Tensor Imaging
FA in Uncinate Fasciculus ROI in Schizophrenia using Slicer
Based on Kubicki et al., 2002
National Alliance for Medical Image Computing http://na-mic.org
Diffusion Tensor Imaging
Healthy Control
Patient with Schizophrenia
C1 - rostrum and genuC2 - anterior truncusC3 - middle truncusC4 - posterior truncusC5 - isthmus and splenium
[Wang et al. 2005]
Integration of Corpus Callosum Subregion ROIs with Tractography
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI
Cognitive Task Development and Validation: Probing Frontal-Temporal Circuitry
Primary Tasks:
Working memory Episodic memory Semantic memory
Secondary Tasks (other Circuitry)
Self-reflection Reward Planning
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI
Prospective Data Collection on 1.5T Magnet: Interim Analysis of Patients with
Schizophrenia and Controls
Controls Patients p (n=8) (n=13)
Age (yrs.) 30.8 (7.1) 36.4 (10.3) NSEduc (yrs.)* 16.9 (2.4) 14.6 (1.9) .05Sex (M,F) 3, 5 9, 3 NSWRAT Reading 111.5 (4.7) 105.0 (10.5) NSCVLT-II Total 1-5 58.4 (6.4) 38.6 (10.4) .001
* matched for parental SES
National Alliance for Medical Image Computing http://na-mic.org
Functional MRIn-Back Working Memory Task
Performance on the In-Scanner Working Memory (3-back) Task
0-back 1-back 2-back 3-back
% C
orre
ct (
adju
sted
for
gue
ssin
g)
40
50
60
70
80
90
100
ControlsPts with Schizophrenia
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI – Behavioral Performance
Interim analysis
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI
FMRI Activation During 3-Back in Schizophrenia
ControlsN = 8
PatientsN = 12
Simple Effects
p = .01Interim analysis
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI
FMRI Activation During 3-Back in Schizophrenia
Controls > Patients
p = .01
Patients > Controls
Interim analysis
National Alliance for Medical Image Computing http://na-mic.org
Functional MRIVerbal Encoding/Retrieval Episodic Memory Task
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI – Behavioral PerformanceVerbal Encoding/Retrieval Episodic Memory Task
Performance on the In-Scanner Recognition Memory Task
New Words WM Old Words LD Old Words
% C
orr
ect
(ad
just
ed
for
gues
sin
g)
60
70
80
90
100
ControlsPts with Schizophrenia
Interim analysis
Reaction Time for Performance on the Recognition Memory Task
New Words WM Old Words LD Old Words
Re
actio
n T
ime
0.8
0.9
1.0
1.1
1.2
1.3
1.4
ControlsPts with Schizophrenia
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI – Behavioral PerformanceVerbal Encoding/Retrieval Episodic Memory Task
Interim analysis
National Alliance for Medical Image Computing http://na-mic.org
Functional MRI
FMRI Activation During Continuous Auditory-Verbal Memory (new > old word contrast) in Patients with Schizophrenia
PatientsN = 7 p = .01Interim analysis
Verbal Encoding/Retrieval Episodic Memory Task
National Alliance for Medical Image Computing http://na-mic.org
Collaborations and Progress
Shape Analysis with UNC Group: Martin Styner, Guido Gerig Hippocampal Shape - Dartmouth Data: SPHARM
Overall Mean Left Mean Right Mean
http://www.na-mic.org/Wiki/index.php/Progress_Report:Shape_Analysis
Skeleton-based subdivision
National Alliance for Medical Image Computing http://na-mic.org
Collaborations and Progress
fMRI in Slicer – fMRIEngine - Wendy Plesniak and Haiying Liu Met Dec. 14th, 2005 to discuss progress and future
improvements to be made Have supplied motor data from two controls to test results
from module and compare with results from SPM2 fMRI tasks – Brigham group
Porting of our tasks to BWH Meeting with Marek Kubicki on Dec. 20th, 2005 to
demonstrate our tasks and how we utilize them Training session at BWH
Tara McHugh visited to get in depth training in Slicer for
tracing structures – Dec. 1st, 2005
National Alliance for Medical Image Computing http://na-mic.org
Collaborations and Progress
Working with Steve Pieper to test 64-bit Linux version of Slicer Worked with Steve Pieper, Gordon Kindlmann, Xiaodong Tao,
and Josh Snyder to convert Dartmouth DTI data to nrrd format and
solve lingering orientation issues DTI Path of Interest – MGH – David Tuch and Josh Snyder
Dartmouth request for tools to help relate DTI fiber tract
pathways to connections in fMRI identified circuits Collaboration to implement DTI Path of Interest Program at
Dartmouth site Successful initial results on NAMIC01 healthy control by both
Josh Snyder at MGH and John West at Dartmouth Plans: integrate functional ROIs derived from fMRI tasks
National Alliance for Medical Image Computing http://na-mic.org
DTI Path of Interest – Initial Results
Collaboration with David Tuch & Josh Snyder (MGH)
Description – program finds the optimal path between two or
more ROIs using probability statistics
Implementation C-code, Matlab and FSL scripts to generate optimal path Slicer for visualization and tracing of input ROIs Full implementation in Slicer as module is a future project
Initial results from NAMIC01 healthy control
National Alliance for Medical Image Computing http://na-mic.org
DTI Path of Interest – Initial Results
Hippocampal ROI to Ventral Prefrontal ROIUncinate Fasciculus
National Alliance for Medical Image Computing http://na-mic.org
DTI Path of Interest – Initial Results
Receptive Speech Area ROI to Expressive Speech Area ROIArcuate Fasciculus
National Alliance for Medical Image Computing http://na-mic.org
DTI Path of Interest – Initial Results
Hippo ROI to Expressive Speech Area ROIUsing Receptive Speech Area ROI as Guide
Arcuate Fasciculus
National Alliance for Medical Image Computing http://na-mic.org
Planned Applications & Developments
Integration of fMRI and DTI data, including tractography (see tool “wish list”)
Effective and functional connectivity during cognitive tasks (see tool “wish list”)
Examine structural (ROI, DTI) and functional (fMRI) correlates of symptoms and cognition
Expand use of methods to other populations bipolar disorder, OCD, MCI/AD, MS, TBI, epilepsy, other disorders
National Alliance for Medical Image Computing http://na-mic.org
Neuroimaging Research Center 3T Magnet
National Alliance for Medical Image Computing http://na-mic.org
Neuroimaging Research Center 3T Magnet
National Alliance for Medical Image Computing http://na-mic.org
Brain Imaging Laboratory: People
FACULTY PIs (Psychiatry): • Laura A. Flashman, Ph.D.• Alan I. Green, M.D. • Thomas W. McAllister, M.D. • Brenna C. McDonald, Psy.D. • Robert M. Roth, Ph.D. • Andrew J. Saykin, Psy.D.• Heather A. Wishart, Ph.D.
POST-DOCTORAL FELLOWS:• Howard Cleavinger, Ph.D. (Epilepsy)• Ellen Crouse, Ph.D. (MCI, chemotherapy)• Nancy Koven, Ph.D. (Schizophrenia)• Nadia Paré Ph.D. (MCI, ADNI)• Jo Cara Pendergrass, Ph.D. (Schizophrenia)
KEY TECHNICAL COLLABORATORS: • Konstantinos Arfanakis, Ph.D. (DTI; IIT)• Fillia Makedon , Ph.D. (Computer Science)• James C. Ford, Ph.D. (Computer Science)• Li Shen, Ph.D. (CS, UMASS-Dartmouth)• Jason Moore, Ph.D. (Comp Genetics)
BIL COORDINATOR • Heather Pixley, B.A.
IMAGE ANALYSTS & SYSTEMS ADMIN:• John MacDonald, M.A. • Tara McHugh, M.A. • Paul Wang, B.A. • John West, M.S.
STUDY COORDINATORS: • Mary Hynes, RN (TBI)• Ariel Rosen, B.A. (MS)
NEUROSCIENCE TECHNICIANS:• Carrie Kruck, B.A. (chemotherapy)• Margaret Nordstrom, B.A. (MCI)
RESEARCH MRI TECHNOLOGISTS:• Jorge A. Forero• Alice E. Davison
National Alliance for Medical Image Computing http://na-mic.org
Dartmouth Brain Imaging Laboratory
December, 2005