Conclusion Estimating the burden of fungal disease in Vietnam ResultsBackground Methods The...
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Conclusion Estimating the burden of fungal disease in Vietnam ResultsBackground Methods The prevalence of fungal infections in Vietnam is poorly described,
Conclusion Estimating the burden of fungal disease in Vietnam
ResultsBackground Methods The prevalence of fungal infections in
Vietnam is poorly described, and there is no formal surveillance
Fungal infections are of increasing clinical and economic
importance world wide, with mortality ranging from 15-50% We
estimated the incidence and prevalence of fungal diseases in
Vietnam, using a validated actuarial approach Estimates were based
on current reports from Vietnam, epidemiological studies from the
local region and global data Population data were sourced from the
General Statistics Office of Vietnam and the WHO World Health
Statistics Report HIV/AIDS related data were sourced from UNAIDS
and the Vietnamese Ministry of Health Prevalence of asthma, Chronic
Obstructive Pulmonary Disease (COPD), Tuberculosis (TB), cancer,
transplant and intensive care were derived from local and regional
data sources, and personal communications The actuarial approach
used was previously described by Denning 1 J. Beardsley 1, D.W.
Denning 2, N.V. Chau 3, N.T.B. Yen 4, J.A. Crump 5, J.N. Day 1
1.Oxford University Clinical Research Unit, Vietnam
([email protected]). 2. The National Aspergillosis Centre in
association with the LIFE program www.LIFE-Worldwide.org,
University Hospital of South Manchester and The University of
Manchester, UK. 3. Hospital for Tropical Diseases, HCMC, Vietnam.
4. Pham Ngoc Thach Hospital, HCMC, Vietnam 5. University of Otago,
New Zealand. M 48.8% F 51.2% Gender/Age Structure Total population
90,796,000 Children 22.9% Female >50 17.2% Underlying conditions
associated with fungal disease Pulmonary TB (incidence/yr)
Total130,000 HIV+9300 HIV/AIDS (est. current cases) 256,845
COPD/Asthma (prevalence) COPD 6.7% Asthma 1.04% Stem Cell
Transplant 22.5/ year Renal Transplant 130/ year Critical Care Beds
11,325 nationally This is the first attempt to comprehensively
describe invasive fungal infections in Vietnam and suggests that
the majority of severe disease is due to Aspergillus species,
driven by the high incidence of pulmonary TB The AIDS epidemic
highlights opportunistic infections, such as penicilliosis and
cryptococcosis. Penicilliosis is a problem unique to South and
South East Asia. As the availability of transplants and other
immune-modulating therapies increase, the epidemiology of fungal
infection is likely to change These data should be verified by
further epidemiological approaches but in the absence of formal
surveillance, they provide a useful baseline indication of disease
prevalence to inform future research and resource allocation 1.
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map courtesy of Corinne Thompson, Epidemiologist, OUCRU
Vietnam