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Comparison of Echocardiographic Methods to Cardiac Magnetic Resonance Imaging in Survivors of Pediatric Cancer Jeet Mehta 1, Sanket Shah 1,2 Wendy McClellan 2, Joy M. Fulbright 2, Jignesh D. Dalal 1,2, Joshua Q. Knowlton 1,2, Ashley K. Sherman 2, Anitha Parthiban 1,2, Girish Shirali 1,2 1 UMKC School of Medicine, 2 Childrens Mercy Hospital Introduction Pediatric echocardiogram labs report left ventricle [LV] ejection fraction [EF] using either M-mode [MM] or 2D echo [2DE] for cancer patients. In adults, 3D echo [3DE] measurement of LV volume and function is now rapid, more accurate and reproducible than 2DE and MM. Our study aims to show the feasibility and validity of 3DE measurements in pediatric cancer patients in comparison to cardiac MRI as gold standard, and to compare with other methods, including MM and 2DE. Methods The study population consisted of children and young adults being followed up after cancer remission at Childrens Mercy Hospital. Families with children older than 10 years of age who have survived > 2 years after completion of cancer treatment were enrolled to participate in the study. An MRI was performed the same day as clinically- indicated echocardiograms wherein LV function was quantified using MM and 2DE. Additional 3DE images were acquired from the apical window. MM, 2DE and 3DE ventricular volume and function analysis was performed offline using programs such as Xcelera and QLab (Philips) and blinded to MRI measurements. The study is approved by the institutional review board [IRB] of Childrens Mercy Hospital. Results For the 41 subjects studied, age ranged from 10 to 22 years, with a median duration of cancer remission of 10 years. Forty had received anthracyclines [median dose of 175 mg/m 2 of body surface area and 9 subjects receiving dosage of 300 mg/m 2 ], 32 had received alkylating agents, 20 had radiation therapy; 20 were girls and 39 were Caucasians. Satisfactory 3DE images were obtained in 37/41 subjects; MRI was obtained in all 41. LV end-diastolic volume by 3DE had a stronger correlation with MRI (gold standard) [r=0.71, p