Commonly Used EPA Registered Canine Topical Flea and Tick Control Products

External parasites pose a threat to your patients year round, so clients deserve your very best advice when developing a strategy for controlling infestations. This chart represents the most commonly used EPA-regulated canine topical flea & tick control products as of April 1, 2016. All products are applied monthly unless otherwise indicated. Please refer to individual product labels and package information for more details on target parasites, contraindications, and safety information. Products listed here are not for use on cats.

*Refer to product label for specific tick, mosquito, fly, and mite species affected.† Indicates that the product repels the selected parasite.

The trademarks and trade names listed above are the property of their respective owners. This poster is an independent publication and has not been authorized, sponsored, or otherwise approved by any of the companies who own the products listed.

Jorge Guerrero,DiplEVPC (ret),DVM, MSc, PhD,is an internation-ally recognizedveterinary para-sitologist, with aunique blend ofexperience in the animal health in-dustry and academia. He has beenAdjunct Professor of Parasitologyat the University of Pennsylvaniasince 1983. Dr. Guerrero is PastPresident of the North AmericanVeterinary Conference (NAVC) anda recipient of the DistinguishedVeterinary Parasitologists Awardfor 2005, granted by the AmericanAssociation of Veterinary Parasitolo-gists. Dr. Guerrero has authoredor co-authored more than 170refereed original research articlesand book chapters, and in 2010 heco-authored a book on helminthparasite infections of dogs and cats.

Activyl® Merck 773-94 X X - - - - - - 8 weeks 19.53% Indoxacarb

Activyl® Tick Plus Merck 773-95 X X X - - - - - 8 weeks 13.01% Indoxacarb + 42.5% Permethrin

Adams™ Spot-On® Farnam 2724-811270 X X X - - X - - 6 months 30% Etofenprox 5% PBO 3.6% (S)-Methoprene

Advantage® II Bayer 11556-125 (127,128,130) X X - - - - X - 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen

Advecta™ II CapInnoVet 2596-180-91384 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen

Adventure™ Plus Promika 91300-2 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen

Barricade™ Spot On® Farnam 88052-8-89459 X - X - - - X - 8 weeks 9.7% Fipronil

Bio Spot® Spot On® Farnam 2724-497-270 X X X - - X - - 6 months 45% Permethrin 3% (S)-Methoprene

Bio Spot® Defense™ Farnam 2724-796-270 X X X - - X - - 6 months 30% Etofenprox 5% PBO 3.6% (S)-Methoprene

Certifect® Merial 65331-7 X X X X X - X - 8 weeks 9.8% Fipronil + 22.1% Amitraz 8.8% (S)-Methoprene

Defense Care™ Bayer 1156-135 X - X - - X X X 7 weeks 8.8% Imidacloprid + 44% Permethrin

Effitix® Virbac 2382-187 X - X X - X X X 12 week 6.01% Fipronil + 44.8% Permethrin

Flea 5X Plus™ 1800 PetMeds 2517-134-88832 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

Fortress™ Spot On® Farnam 88052-8-89459 X - X - - - X - 8 weeks 9.7% Fipronil

Frontline® Gold Merial 2596-178-65331 X X X X 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene + 0.25% Pyriproxyfen

Frontline® TriTak® Merial 2517-142-65331 X X X X - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin 8.8% (S)-Methoprene

Frontline® Plus Merial 65331-5 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

Happy Jack® DuraSpot™ Happy Jack Inc. 67505-3-2781 X X X X X X 12 weeks 45% Permethrin 5.0% Pyriproxyfen

Hartz® UltraGuard® Hartz 2596-167 X - X - X X - - 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264

Hartz® UltraGuard Plus® Hartz 2596-168 X X X - X X - - 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 0.5% Pyriproxyfen

Hartz® UltraGuard Pro® Hartz 2596-169 X X X - X X - - 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 0.5% Pyriproxyfen + 0.25% (S)-Methoprene

Hartz First Defense® Hartz 2596-163 X - X - - - X - 8 weeks 9.7% Fipronil

K9 Advantix® Bayer 11556-132 (133,134,135) X - X - - X X X 7 weeks 8.8% Imidacloprid + 44% Permethrin

K9 Advantix® II Bayer 11556-141 (142,143,144) X X X - - X X X 7 weeks 8.8% Imidacloprid + 44% Permethrin 0.44% Pyriproxyfen

Liberty® 50 Plus IGR Spot-On Star Horse Products 75844-8-81021 X X X X - X X - 12 weeks 50% Permethrin 1.2% Pyriproxyfen

Para / Defense™ CapInnoVet 2596-180-91384 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen

ParaStar® Novartis 70585-12 X - X - - - X - 8 weeks 9.7% Fipronil

ParaStar® Plus Novartis 70585-13 X - X X - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin

PetAction™ Plus TruRX, LLC 91019-1 X X X X - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

Pet Armor® Perrigo 86230-2-85495 X - X - - - X - 8 weeks 9.7% Fipronil

Pet Armor® Advanced 2 Perrigo 2517-176 X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen

Pet Armor® Plus Perrigo 2517-134 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

PetLock™ Plus TruRX, LLC 88052-13-89609 X X X X X - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

Pet Lock™ II CapInnoVet 2596-180-91384 X X X 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen

Sentry® FiproGuard® Perrigo 2517-136 X - X - - - X - 8 weeks 9.7% Fipronil

Sentry® FiproGuard® Max Perrigo 2517-140 X - X - - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin

Sentry® FiproGuard® Plus Perrigo 2517-134 X X X - - - X - 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

Sentry® Pro Squeeze-On Perrigo 2517-87 X X X - - X - - 12 weeks 45% Permethrin 1.9% Pyriproxyfen

Sentry® Pro XFT Large Dog Perrigo 2517-130 X X X - - X - - 12 weeks 30% Cyphenothrin 2% Pyriproxyfen

Sentry Pro® XFT Small/Medium Dog Perrigo 2517-129 X X X - - X - - 12 weeks 20% Cyphenothrin 2% Pyriproxyfen

Sentry Pro® Toy Dog Perrigo 2517-133 X X X - - X - - 12 weeks 55% Etofenprox 2.2% Pyriproxyfen

Sergeant's® Pronyl OTC™ Perrigo 2517-136 X - X - - - X - 8 weeks 9.7% Fipronil

Sergeant's® Pronyl OTC™ Max Perrigo 2517-140 X - X - - - X - 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin

Sergeant's® Squeeze-On Perrigo 2517-126 X X X - - X - - 12 weeks 45% Permethrin 1.2% (S)-Methoprene

ShieldTec™ Plus Promika 91300-1 X X X X X X 12 weeks 45% Permethrin 5.0% Pyriproxyfen

SpectraSure® Plus IGR Durvet 53883-351-89400 X - X - - - X - 12 weeks 9.8% Fipronil 8.8% (S)-Methoprene

TripleGuard™ PetBalance 67505-3-88966 X T X XT - - X X - 12 weeks 45% Permethrin 5% Pyriproxyfen

Vectra® Ceva 83399-10 X X - - - - - - 8 weeks 22% Dinotefuran 3% Pyriproxyfen

Vectra 3D® Ceva 83399-6 X X X - - X X X 7 weeks 4.95% Dinotefuran + 36.08% Permethrin 0.44% Pyriproxyfen

Vet Guard® Plus Pet IQ 67505-3-88966l X X X - - X X - 12 weeks 45% Permethrin 5% Pyriproxyfen

Zodiac® Spot On® Farnam 2724-497 X X X - - X - - 6 months 45% Permethrin 3% (S)-Methoprene

ZoGuard™ Plus Promika 53883-351-91300 X X X X 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene

Updated: April, 2016.Information presented is believed to be accurate, but not guaranteed.

Canine P

roducts

Man

ufactu

rer

EPA Reg

Number

Earli

est A

ge for U

se

Killing In

gredien

ts

Syner

gist In

gredien

ts

Insect

Growth

Regulat

ors (IG

Rs)

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Control

Pre-a

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Kills A

dult Fle

as

Kills Pr

e-adult

Fleas

(Eggs/L

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Kills Ti

cks*

Controls

Mite

s*

Kills Ti

ck N

ymphs &

Larv

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Kills/R

epels

Mosq

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*

Kills Li

ce

Kills Fl

ies*

Active Ingredients

† †