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CHU CHEN, MS, PhD, NRCC, DABCC

PERSONAL DATA Address: Chu Chen, MS, PhD, NRCC, DABCC Full Member Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, Mail Stop M5-C800 P.O. Box 19024

Seattle, Washington 98109-1024 Tel: (206) 667–6644 Fax: (206) 667–2537 E–mail: cchen@fhcrc.org Citizenship: USA Gender: Female EDUCATION 2003 Fifth Annual Seattle Epidemiology & Biostatistics Summer Section at University of Washington,

sponsored by Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs, and Department of Epidemiology and Department of Biostatistics, University of Washington.

2000 New England Epidemiology Institute Summer Course, Tufts University. 1990-1992 Senior Fellow, Division of Clinical Chemistry, Department of Laboratory Medicine, University of

Washington, Seattle, Washington. Second Year Specialty Training: Clinical Toxicology. 1987-1990 Postdoctoral Research Associate, Laboratory of Maxine Linial, Ph.D., Member, Program in

Molecular Virology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

1983-1986 Individual National Research Service Award Postdoctoral Fellow, Laboratory of Sen–itiroh

Hakomori, M.D., Ph.D., Member, Program in Biochemical Oncology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington and Professor, Department of Pathobiology, University of Washington.

1982 Ph.D. in Biochemistry, University of Washington, Seattle, Washington.

Dissertation: "Structure and Reactivity of the Small Spherical High Density Lipoproteins in Familial Lecithin: Cholesterol Acyltransferase Deficiency as Compared with the Structure and Reactivity of Artificially Formed Lipoproteins." Dissertation Advisor: John A. Glomset, M.D., PhD., Professor, Department of Biochemistry and Investigator, Howard Hughes Medical Institute, University of Washington.

1971 M.S. in Botany, Specialization: Medical Mycology, Ohio State University, Columbus, Ohio. Thesis:

"The Effect of Chlorination on the Survival of Candida albicans (strains #8314, 8329, 8335, 8282)." Thesis Advisor: John A. Schmidt, Ph.D.

1968 B.S. in Botany, National Taiwan University, Taipei, Taiwan, Republic of China. PROFESSIONAL POSITIONS

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2006-present Affiliate Professor, Department of Epidemiology, School of Public Health and Community Medicine and Department of Otolaryngology/Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington.

2005–present Full Member, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 2002–present Member, Fred Hutchinson Cancer Research Center/ University of Washington Cancer

Consortium, Seattle, Washington 2001-2006 Affiliate Associate Professor, Department of Otolaryngology/Head and Neck Surgery, School of

Medicine, University of Washington, Seattle, Washington. 2000-2006 Affiliate Associate Professor, Department of Epidemiology, School of Public Health and

Community Medicine, University of Washington, Seattle, Washington. 1999-2005 Associate Member, Program in Epidemiology, Division of Public Health Sciences, Fred

Hutchinson Cancer Research Center, Seattle, Washington. 1999 Assistant Member, Program in Epidemiology, Division of Public Health Sciences, Fred

Hutchinson Cancer Research Center, Seattle, Washington. 1997-present Graduate School Faculty, Department of Epidemiology, University of Washington, Seattle,

Washington. 1995-1999 Assistant Member, Program in Cancer Biology, Division of Public Health Sciences, Fred

Hutchinson Cancer Research Center, Seattle, Washington. 1992-1997 Founder and Director of Public Health Sciences Core Laboratory, Program in Cancer Biology,

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

1992, 1996 Clinical Laboratory Inspector, College of American Pathologists. 1992-1993 Clinical Chemist, Providence Hospital, Everett, Washington. 1974-1976 Research Technician II, Division of Ophthalmology, Department of Surgery, Case Western

Reserve University, Cleveland, Ohio. Project: Chemistry of Rhodopsin. 1972-1974 Senior Research Technician, Michigan State University/Atomic Energy

Commission Plant Research Laboratory, East Lansing, Michigan. Project: Physiology of Abscisic Acid and Xanthoxin.

1972 Medical Mycologist/Microbiologist, Clinical Laboratory, W.A. Foote Memorial Hospital, Jackson, Michigan. CURRENT GRANT SUPPORT 1. FFPE Validation of a Survival Gene Signature in HPV-Negative Oral Cavity Cancer NIH/NCI RO1 CA177736-01A 1/1/2015-12/31/2017 Award: $723,600 (Y1) Role on Project: Principal Investigator The goal of this study is to conduct a multicenter study to transport the testing of a prognostic gene

expression signature from using fresh frozen tumors to hospital paraffin-embedded tumor blocks and from using Affymetrix gene expression arrays to the NanoString platform.

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2. Salivary Metabolite Biomarkers for Diagnosing Nodal Metastasis in Oral Cancer

NIH/NCI R21 CA187151 7/01/2015-6/30/2017

Award: $248,717 Role on Project: Principal Investigator

Using advanced metabolomics profiling methods and a well-characterized biorepository, this project will test the hypothesis that a saliva-based metabolite profile can distinguish patients with squamous cell oral cavity cancer who do and do not have lymph node metastases.

3. Integration of a prognostic gene signature and UW OncoPlex test to define the mutational landscape of

head and neck cancer (HNC) with poor survival Oncoscape Specimen Utilization Grant, Solid Tumor Translational Research Program, Fred Hutchinson Cancer Research Center 7/01/2015-6/30/2017 (NCE), Principal Investigator: Eduardo Mendez Award: $100,000

Role on Project: Co-Principal Investigator This project will test 100 samples in our HNC biorepository for our poor prognosis 131 gene signature test and determine the mutational landscape in genes included in the Oncoplex platform of OSCCs with high risk score for the 131 gene signature profile; and validate gene signature-associated mutational profile in a panel of 303 tumors from TCGA.

4. Clinical Coordinating Center for the Clinical Trial and Observation of the Women’s Health Initiative NIH/NHLBI N01-WH-11-11, Principal Investigator: Garnet Anderson 9/1/2011-3/31/2016 Award: $6,435,608 Role on Project: Co-Investigator The major goal of this project is to establish and operate a Clinical Coordinating Center to support the

Women’s Health Initiative Clinical Trial and Observational Study. 5. Integrative Genomics Approach Therapeutic Target Selection in Oral Cancer Metastasis. American Cancer Society FDN RSG 13 0661 01 TBG, Principal Investigator: Eduardo Mendez 1/1/2013-12/31/2016 Award: $150,000 Role on Project: Co-Investigator The purpose of this grant is to identify genes whose expression is associated with abnormal copy

number which are unique to metastatic oral squamous cell carcinoma (OSCC). In addition, this study will determine which of these candidate genes have the highest association with OSCC survival and which have the highest effect on cell survival and tumor biology in in vitro models of OSCC metastasis.

6. Post GWA Studies in Testicular Germ Cell Tumors NIH/NCI R01 CA164947, Principal Investigator: Kate Nathanson 9/1/2012-8/31/2016 Award: $80,120 Role on Project: Co-Investigator The results of this project will provide new information on the contribution of risk alleles to the etiology of

TGCT. Knowledge gained also will serve to heighten our understanding of the underlying biology of TGCT and its related conditions. We expect that ultimately this information may provide for novel advances in determining risk assessment for this early onset cancer.

PREVIOUS GRANT SUPPORT 1. GM3 Sialytransferase and Cell Transformation.

Individual National Research Service Award, F32 CA07491 11/03/1983-11/02/1986

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Award: $59,736 Role on Project: Principal Investigator

2. Glutathione S–Transferase and Anogenital Cancers.

NIH R01 ES06728, 5/1/1994-11/30/1997 Award: $725,988 Role on Project: Principal Investigator

3. Effects of Soy and Wheat Bran Feeding on Serum and Urinary Steroid Hormone Levels in Premenopausal Women: A Pilot Project. Parent Project: Seattle Breast Cancer Research Program, Principal Investigator: David Thomas NIH/NCI R21 CA66186 1/1/1996-12/31/1996 Award: $15,000 Role on Project: Principal Investigator

4. Estrogen Receptor Polymorphisms and Breast Cancer in Young Women: A Pilot Project

Parent Project: Seattle Breast Cancer Research Program, Principal Investigator: David Thomas. NIH/NCI R21 CA66186 1/1/1998-12/31/1998 Award: $15,415 Role on Project: Principal Investigator

5. Prostate Cancer in Chinese Men Laboratory component of a case–control study conducted by Dr. Ann Hsing of the Environmental

Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute. NCI Contract 263–MQ–822580 2/1/1999–8/31/1999 Award: $80,080 Role on Project: Principal Investigator 6. Phytoestrogens, Organochlorines, and Fibroid Risk

NIH/NIEHS 5 R01 ES08305, Principal Investigator: Stephen Schwartz 9/1/1996-8/31/2001 Award: $665,420 Role on Project: Co–Investigator

7. Diet, Cell Proliferation, and Breast Cancer in Shanghai NIH/NCI R01 CA75332, Principal Investigator: David Thomas 7/1/1997-6/30/2002 Award: $363,782 Role on Project: Co–Investigator

8. Oral Cancer: DNA Polymorphisms in Carcinogen Metabolism NIH R01 DE 12609, Principal Investigator: Stephen Schwartz 9/1/1998-6/30/2002 Award: $1,058,643 Role on Project: Co–Investigator 9. 60–Hz Magnetic Fields and Hormone Levels in Women NIH R01 CA80346, Principal Investigator: Scott Davis 9/1/1998–3/31/2002 Award: 1,234,735 Role on Project: Co–Investigator

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10. Endometrial Cancer and CYP1A1, GSTM1 & T1 Polymorphisms

NIH/NCI R03 CA 80636 10/1/1998–8/31/2001 Award: $172,967 Role on Project: Principal Investigator

11. Endogenous Sex Hormones, Genetics, and Prostate Cancer

NIH/NCI R01 CA78812 4/1/1999-3/31/2003 Award: $988,629

Role on Project: Principal Investigator 12. Reproductive/Contraceptive Risk Factors & Endometriosis NIH/NICHD R01 HD–33792–05, Principal Investigator: Victoria Holt 7/1/1999-4/30/2003 Award: $445,874 Role on Project: Co–Investigator. 13. Adiposity Related Biomarkers and Breast Tumor Size

NIH R03 CA91251, Principal Investigator: Kathleen Malone 4/1/2001-3/31/2003 Award: $171,905 Role on Project: Co–Investigator.

14. Breast Cancer and the Birth Control Pill: Case–Control Study of Perimenopausal and Past Oral

Contraceptive Use NIH/NCI N01 HD–2–3166, Principal Investigator: Janet Daling 9/30/1992-9/29/2003 Award: $7,811,162 Supplement: Genetic Susceptibility and Risk of Breast Cancer Principal Investigator: Kathleen Malone 7/1/1998-9/29/2003 Chen Laboratory Component: $99,535 Role on Project: Co–investigator

15. IGF–1 Levels and the Incidence of Prostate Cancer NIH/NCI R01 CA85064, Principal Investigator: Noel S. Weiss 7/14/2000-12/31/2003 Award: $722,389 Role on Project: Co–Investigator 16. Insulin–like Growth Factors and Esophageal Adenocarcinoma

NIH/NCI, R03 CA099897, Principal Investigator: Thomas Vaughan 9/30/2002-9/29/2004 Award: $100,000 Role on Project: Co–Investigator.

17. Molecular Epidemiology of Testicular Carcinoma

NIH/NCI R01 CA85914, Principal Investigator: Stephen Schwartz 6/1/2000-5/31/2005 Award: $944,177,

Role on Project: Co–Investigator. 18. Molecular Epidemiology of Testicular Carcinoma (Supplement)

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NIH/NCI R01 CA85914, Principal Investigator: Stephen Schwartz 6/1/2000-5/31/2005 Award: $735,250, Role on Project: Co–Investigator (concurrent with effort on “Molecular Epidemiology of Testicular Carcinoma” NIH CA85914)

19. Persistent Organic Pollutants and Endometriosis Risk EPA R829438–01–0, Principal Investigator: Victoria Holt 3/25/2002-3/24/2006 Award: $966,841 Role on Project: Co–Investigator.

20. Breast Cancer and Gene Polymorphisms in Chinese Women NIH/NCI R01 CA84141 4/1/2001-3/31/2006 Award: $818,101

Role on Project: Principal Investigator. 21. Persistent Organochlorines and Testicular Cancer Risk

NIH/NCI R01 CA 95790, Principal Investigator: Stephen Schwartz 9/27/2001–8/31/2006 Award: $800,000 Role on Project: Co–Investigator.

22. Glutathione Transferases in Humans: Dietary Influences NIH R01 CA70913, Principal Investigator: Johanna Lampe 1/14/2002-11/30/2006 Award: $1,877,846 Role on Project: Co–Investigator 23. Reproductive and Hormonal Risk Factors for Adenomyosis

NIH/NCI R01 HD40398, Principal Investigator: Victoria Holt 3/1/2002-1/31/2007 Award: $1,984,349

Role on Project: Co–Investigator 24. Night Shift Workers and Hormone Levels in Women NIH R01 CA97090, Principal Investigator: Scott Davis 9/11/2002-8/31/2008 Award: $1,471,412 Role on Project: Co–Investigator 25. Oral Cancer: Molecular Profiles & Clinical Outcomes

NIH/NCI R01CA095419-01A1 6/1/2003-8/31/2009 Award: $2,510,332

Role on Project: Principal Investigator 26. Molecular Epidemiology of Endometrial Cancer

NIH/NCI R01 CA105212 9/21/2004-8/31/2010 Award: $1,251,867

Role on Project: Principal Investigator 27. Environment, Gene and Testicular Cancer Risk

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NIH/NIEHS/NCI R01 104786, Principal Investigator: Tongzhang Zheng (Yale University) 5/11/2006-3/31/2011 Subcontract Award: $188,575

Role on Project: Principal Investigator of FHCRC Subaward

28. Clinical Coordinating Center for the Clinical Trial and Observation of the Women’s Health Initiative NIH/NCI N01-WH-2-2110, Principal Investigator: Ross Prentice 9/30/1992-9/30/2011 Award: $150,185,267

Role on Project: Co-Investigator 29. Molecular Epidemiology of Testicular Carcinoma

NIH/NCI R01 CA85914, Principal Investigator: Stephen Schwartz 6/1/2005-4/30/2012 Award: $2,803,897

Role on Project: Co-Investigator 30. Night Shift Work and Hormone Levels in Men

NIH/NCI R01 CA116400, Principal Investigator: Scott Davis 7/1/2007-5/31/2012 Award: $1,891,120 Role on Project: Co-Investigator

31. Oral Cancer: Molecular Profiles & Clinical Outcomes

NIH/NCI 2R01CA095419-07 9/1/2009-8/31/2012 (NCE) Award: $1,140,546

Role on Project: Principal Investigator 32. Genome-Wide Association Study of Endometrial Cancer

NIH/NCI 1R01CA134958-01A1, Principal Investigator: Immaculata DeVivo 9/30/2009-8/31/2012 (NCE) Award: $3,985,223

Role on Project: Co-Investigator & Principal Investigator of FHCRC Subaward 33. Integration of Genomic and Transcriptomic Changes to Aid in Novel Biomarker and Therapeutic Target

Discovery for Metastatic Oral Squamous Cell Carcinoma Howard Hughes Medical Institute Physician-Scientist Early Career Development Award, Principal

Investigator: Eduardo Mendez 8/1/2008-7/31/2013 Subcontract Award: $19,693 Role on Project: Co-Investigator & Principal Investigator of FHCRC Subaward 34. Molecular Epidemiology of Lung Cancer

NIH/NCI R01 CA111703 8/10/2006-7/31/2013 (2nd NCE) Award: $1,270,391 Role on Project: Principal Investigator

35. FHCRC OralChip Study SAIC-F/NIH 123XS531-STO1 10/23/2012-7/31/2014 Award: $59,000 Role on Project: Principal Investigator

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36. Tumor Infiltrating Lymphocytes and Survival from Oral Squamous Cell Cancer Team Science Translational Research Grant, Solid Tumor Translational Research Program, Fred Hutchinson Cancer Research Center

7/01/2015-6/30/2016 Award: $50,000 Role on Project: Principal Investigator

Patients with HPV-positive oropharyngeal cancer (OPC) have better response to conventional treatments and better survival than do patients with HPV-negative OPC, HPV-positive oral cavity cancer (OCC), or HPV-negative OCC. The specific aim of this pilot study is to evaluate whether there is a difference in the immunoresponse in patients with these four groups of tumors in terms of the tumor-infiltrating lymphocyte (TIL) count and clonality of the T cells, based on our hypothesis that such a difference may be the underlying mechanism that contributes to the difference in survival among these four groups of patients.

37. Telomeres and Lung Cancer Incidence and Prognosis NIH/NCI 5R01 CA151989-01A1, Principal Investigator: Jennifer Doherty 8/8/2011–8/31/2016 Award: $2,499,004 Role on Project: Co-Investigator The goal is to examine whether peripheral blood telomere length is associated with risk and survival from

lung cancer. TEACHING and MENTORING EXPERIENCE Mentoring of Staff Scientist: 2003-2012 Mentoring and sponsoring faculty for Jennifer Doherty, PhD, Senior Staff Scientist, Program in

Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington. Projects: Molecular Epidemiology of Endometrial Cancer; Molecular Epidemiology of Lung Cancer.

2015-present Pawadee Lohavanichbutr, MD. Staff Scientist, Program in Epidemiology, Fred Hutchinson

Cancer Research Center, Seattle, Washington. Project: FFPE Validation of a Survival Gene Signature in HPV-Negative Oral Cavity Cancer.

Mentoring of Postdoctoral Fellows: 1999-2002 Najib Lamharzi, PhD. – Associations of polymorphisms of SRD5A2 and AR genes and prostate

cancer risk.

1999-2000 Xiaoli Wang, PhD. – Promoter regulation of glutathione S–transferase M1 gene. 1998-1999 Wilas Nirunsuksiri, PhD. – Expression of Glutathione S–transferase M1 in HPV16–transfected

human cervical keratinocytes in culture. Mentoring of Physician Scientist, Medical Residents and Medical Students: 2000-present Eduardo Mendez, MD., Associate Professor, University of Washington, Department of

Otolaryngology: Head and Neck Surgery and Assistant Member, FHCRC, Clinical Research Division

- Resident Research (2000-2005) - Named mentor for the following career development awards:

Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Award. Grant No. 049588 (7/01/2006-6/30/2010)

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NIH Roadmap K12 Multidisciplinary Clinical Research Career Development Program. Grant No. K12 HD049100 (9/23/2006-7/31/2011)

Howard Hughes Medical Institute Physician-Scientist Early Career Award. Grant No. 57006501 (8/01/2008-07/31/2013)

Institute of Translational Health Science Small Grants Translational Research Projects Award, University of Washing (7/01/2008-06/30/2009). Project: Integration of genomic and transcriptomic changes in metastatic oral squamous cell carcinoma.

2002-2003 James R. Babington, University of Washington Medical Student Research Training Program

(MSRTP) Project: Genetic variation in matrix metalloproteinase 3 gene and oral squamous cell carcinoma risk: a case control study.

2004-2005 Peter Choi, MD, PhD. Resident, University of Washington, Department of Otolaryngology: Head

and Neck Surgery Project: Oral squamous cell carcinoma: Validation of the expression of consensus markers for its development and metastasis using immunocytochemistry approach

2004-2005 Sirius Yoo, MD. Resident, University of Washington, Department of Otolaryngology: Head and

Neck Surgery Project: MMP9 genotypes and haplotypes in relation to the risk and outcome of oral squamous cell carcinoma of the oral cavity.

2005-2014 Pawadee Lohavanichbutr, MD, MS. Physician, Burlington Family Practice, Burlington, Washington, and Research Associate, FHCRC Projects: Genetic expression profiles of HPV positive and HPV negative oral squamous cell carcinoma; differential expression of microRNA in tissue, saliva and exfoliated oral epithelium between patients with and without oral squamous cell cancer.

2006-2008 Yu Chen, BM, PhD. Amgen Postdoctoral Fellow, FHCRC

Project: Genome–wide loss of heterozygosity and DNA copy number variation and oral squamous cell carcinoma.

2008-2009 Xin Yi, BM, PhD. Postdocotoral Fellow, FHCRC Project: Validation of serum and tissue biomarkers of oral squamous cell carcinoma.

2011 Lori C. Sakoda, PhD. Postdoctoral Fellow, FHCRC Project: Polymorphic variation in nucleotide excision repair in relation to lung cancer susceptibility and prognosis

2015-present Lu Feng, BM, MS. Visiting Physician Scientist, Henan Cancer Hospital/ZhengZhou University, Henan Province, People Republic of China

Mentoring of University of Washington Graduate Students: 1997-present Graduate School Faculty, Department of Epidemiology, University of Washington, Seattle,

Washington and Member of the PhD Dissertation Committees for: Casey Crump, M.D. (1997–1998), Doctoral Dissertation: The GSTT1 gene deletion and risk of acute myelocytic leukemia. PhD conferred, 1998.

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1998-2002 Jennifer Doherty, Doctoral Dissertation: Genetic influences on estrogen biosynthesis, catabolism and response in relation to the incidence of endometrial cancer. PhD conferred, 2002.

2001-2003 Lisa Johnson, Doctoral Dissertation: Obesity related metabolic hormones and breast tumor

proliferation. 2001-2003 Kenneth Fred Adams, Doctoral Dissertation: Serum IGFs: Effects of a soy isoflavone

intervention. 2002-2003 Jacqueline Rose Starr, Doctoral Dissertation: Maternal IGF–1 polymorphisms and the risk of

testicular cancer in sons. 2002-2007 Sid Hossein Siahpush, Doctoral Dissertation: Insulin–like growth factors & esophageal

adenocarcinoma. 2003-2005 Jocelyn Weiss, Doctoral Dissertation: Nucleotide excision repair gene polymorphisms and the

risk of endometrial cancer. 2003-2006 Jennifer Lauren Marino, Doctoral Dissertation: Night shift work and the risk of endometriosis. 2004-2006 Sarah Holt, Doctoral Dissertation: Ovarian cancer risk and polymorphisms involved in estrogen

catabolism. 2005-2008 Inbal Boger–Megiddo, Master Thesis: Association of endogenous hormones and androgen

gene polymorphisms and prostate cancer risk. 2005-2009 Kerryn Reding, Doctoral Dissertation: Genetic variation modifying the effect of hormone therapy

on breast cancer risk. 2007-2011 Lori C. Sakoda, Doctoral Dissertation: Polymorphic variation in nucleotide excision repair in

relation to lung cancer susceptibility and prognosis. 2009-2012 Marni Stott-Miller, Doctoral Dissertation: Glucose metabolism, diabetes and head and neck

cancer risk. 2009 Kaifeng Hung, DDS, Laboratory rotation as a doctoral student in University of Washington,

Department of Oral Biology. Project: Detection of microRNA in saliva and exfoliated cells in oral cancer patients and healthy controls.

2010-2014 Pawadee Lohavanichbutr, MD, Master Thesis: Gene expression in uninvolved oral mucosa of

OSCC patients facilitates identification of markers predictive of OSCC outcomes.

2012 Kazumi Sunny Tsukazawa, Master Thesis: Polymorphisms in microRNA regulation of LIG1 and BAT3 and lung cancer susceptibility.

Mentoring of Undergraduate Students: 2002 Melissa M. Johnson, University of Washington Undergraduate Independent Research,

Epidemiology 499. 2005 Luis N. Enriquez III, University of Washington Undergraduate Independent Research,

Epidemiology 499.

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2008 Rachel Goodman, Trinity College, Summer Internship: OGG1 polymorphisms and lung cancer risk.

2008 Liberto Julianto, University of Washington, Research Volunteer: DNA repair gene olymorphisms

and lung cancer risk. 2008-2009 Kalina Benedict, University of Washington Independent Research, Epidemiology 499. 2010-2011 Akanksha Saxena, University of Washington Independent Research, Epidemiology 499. 2010-2011 Bahrum P. Mehr, University of Washington Program of Initiative for Maximizing Student

Diversity (IMSD), Department of Bioengineering

2012-2013 Joo Park, University of Washington Research Volunteer: microRNA polymorphisms and lung cancer risk.

2014 Claire Russell, Johns Hopkins University Undergraduate Summer Intern: Evaluation of integration of human papillomavirus into the genome of oral squamous cell carcinoma of the oral cavity and oropharynx

Course Teaching: 1995-1998 Participating Lecturer, Course: Methods and Issues in Using Biological Measurements in

Epidemiologic Research. Department of Epidemiology, University of Washington, Seattle, Washington.

1990-1992 Participating Faculty, Course: Lipids, Lipoproteins, and Lipoprotein Metabolism.

Department of Laboratory Medicine, University of Washington, Seattle, Washington. AWARDS & HONORS 1983-1986 Postdoctoral Individual National Research Service Award, NCI, NIH. 1991 Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists. 2005 Honoree, Women of Color Empowered, Northwest Asian Foundation. PROFESSIONAL ACTIVITIES Journal Reviewer: American Journal of Epidemiology Archives of Otolaryngology–Head & Neck Surgery Cancer Cancer Epidemiology, Biomarkers & Prevention Cancer Research Clinical Cancer Research Endocrine-Related Cancer European Journal of Obstetrics and Gynecology and Reproductive Biology Head and Neck Journal of Infectious Disease Journal of Medical Genetics Journal of National Cancer Institute Journal of Oral Pathology & Medicine New England Journal of Medicine Oncogene Oral Oncology Otolaryngology - Head and Neck Surgery

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Co–Chair Biomarkers Affinity Group, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., 2000–2006.

Member Search Committee for Head of Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA., 2000.

Member Biologic Specimen Advisory Group, American Cancer Society. Operations Committee of the American Cancer Society’s National Home Office, 2002–present.

Member International Collaborative Group on Genetic Susceptibility to Environmental Carcinogens, IARC, 2002–present.

Consultant Zuo–Feng Zhang Laboratory, Department of Epidemiology, School of Public Health, University of California, Los Angeles, 2002.

Member International Consortium on Head and Neck Cancer, IARC, 2002–present. Member Staff Scientist Policy Review Group, Public Health Sciences Division, Fred Hutchinson

Cancer Research Center, 2003. Member Promotional Review Committee of Cathy Tangen from Assistant Member to Associate

Member, Public Health Sciences Division, Fred Hutchinson Cancer Research Center 2004.

Member Promotional Review Committee of Cornelia Ulrich from Assistant Member to Associate Member, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2004.

Invited Participant International Endogenous Hormones and Prostate Cancer Collaboration Meeting, July 1–2, 2005, Oxford University, Oxford, United Kingdom.

Invited Participant The 2nd NCI Epidemiology Leadership Conference: Understudied Rare Cancers, September 11–13, 2005, Boston, MA.

Member American Association for Clinical Chemistry Annual Meetings Abstract Review Subcommittee, 2006–2008.

Chair Promotional Review Committee of Christopher Li from Assistant Member to Associate Member, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2006.

External Referee Promotion Review of Dr. Chen–Yang Shen of Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan from Associate Research Fellow to Research Fellow, April, 2007.

Invited Participant “Synergizing Epidemiologic Research on Rare Cancers” meeting, organized by the Clinical and Translational epidemiology Branch, Epidemiology and Genetics Research Program, National Cancer Institute. May 10–11, 2007. Bethesda, Maryland.

Abstract Reviewer 7th International Conference on Head and Neck Cancer. July 19–23, 2008. San Francisco, California

Member Public Health Sciences Division Staff Scientist Policies and Procedures Committee, Fred Hutchinson Cancer Research Center, 2008.

Member Public Health Sciences Division Biospecimen Repository Committee, Fred Hutchinson Cancer Research Center, 2008.

Moderator Proffered Papers Section: Translational: Medical Oncology/Gene therapeutics. The 7th International Conference on Head and Neck Cancer. July 19–23, 2008. San Francisco, California.

Member Editorial Board, Cancer Epidemiology, Biomarkers and Prevention. 2009-present. Member 5-year Review Committee of Johanna W. Lampe, PhD, Full Member, Associate

Division Head, Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2009.

Senior Editor Editorial Board, International Journal of Molecular Epidemiology and Genetics, 2011-present.

Member 5-year Review Committee of Thomas Vaughan, MD, MPH, Full Member, Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2013.

Member Faculty Advisory Committee on Fred Hutchinson Cancer Research Center Genomics Shared Resource, 2013-present.

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Member Promotional Review Committee of Margaret Madeleine from Assistant Member to Associate Member, Public Health Sciences Division, Fred Hutchinson Cancer Research Center 2015.

Mentor AACR-MICR Minority-Serving Institution Faculty - Cancer Center Collaboratives, 2015. Member 5-year Review Committee of Johanna W. Lampe, PhD, Full Member, Associate

Division Head, Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2015.

Member Promotional Review Committee of Margaret Madeleine from Assistant Member to Associate Member, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2015.

International, National, and Local Grant Review Committees: Reviewer National Student Research Forum, 2000. Reviewer Central Lipid Laboratory application for the Cardiovascular Health Study / Multi Ethnic

Study of Atherosclerosis (CHS–MESA) Coordinating Center, Seattle, WA., 2000. Member NIEHS Site Visit Team and Reviewer, NIEHS Center Grant review, University of

Texas/MD Anderson Cancer Center, Smithville, TX, 2000. Reviewer German–Israeli Scientific Cooperation Unit, Division for International Relations and

Information, Ministry of Science Culture & Sport, Israel, 2002. Reviewer Program Project Grant Reviewer, Molecular Cellular Medicine Board, Medical

Research Council, United Kingdom. Review program project grant application on environmental causes of cancer, 2003.

Reviewer NIH/NCI Head and Neck Cancer Specialized Programs of Research Excellence (SPOREs). Review applications in response to PAR 02–126. March 2–3, 2004. Bethesda, Maryland.

Reviewer Singapore National Medical Research Council Grants, 2004. Reviewer NIH/NCI Special Emphasis Panel, ZCA1 SRRB–E (01). Review applications in

response to RFA CA–04–006, “Early Detection Research Network: Biomarkers Developmental Laboratories”. July 7–8, 2004. Bethesda, Maryland.

Reviewer NIH/NCI Special Emphasis Panel, ZCA1 SRRB–E (01). Review applications in response to RFA CA–05–023, “Early Detection Research Network: Biomarkers Developmental Laboratories”. March 23–24, 2005. Bethesda, Maryland.

Reviewer NIH/NIAID Study Section for RFA AI–04–045, entitled, "Center for Medical Countermeasures against Radiation". Review applications to establish Centers for Medical Countermeasures against Radiation (CMCR). The primary goal of the Centers will be to develop new medical products that will protect against, mitigate the effects of, and treat the short– and long–term consequences of radiation exposure due to terrorist attack. June 20–22, 2005. Bethesda, Maryland.

Reviewer NIH/NIDCR Special Emphasis Panel/Scientific Review Group 2006/01 ZDE1 PZ (07). Review R21 (Exploratory/Developmental Research Grant Award) applications in response to Program Announcements PA03–107, PAR05–020 and PA04–134. November 10, 2005.

Reviewer NIH/NIDCR Special Emphasis Panel/Scientific Review Group 2007/01 ZDE1 PZ11. Review R21 (Exploratory/Developmental Research Grant Award) applications in response to Program Announcements PAR06–219 and PAR06–216. November 2, 2006.

Reviewer NIH/NCI GI and Head and Neck Cancer Specialized Programs of Research Excellence (SPOREs), June 11–12, 2007. Bethesda, Maryland.

Member Scientific Review Committee. The 7th International Conference on Head and Neck Cancer. July 19–23, 2008. San Francisco, California.

Reviewer NIH/NIDCR Special Emphasis Panel/Scientific Review Group 2008/10 DSR meeting, June 12–13, 2008. Bethesda, Maryland.

Reviewer Singapore National Medical Research Council Grants. July, 2008.

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Expert French National Evaluation Committee for Cancer Translational Research. February, 2009.

Member NIH/NIDCR Special Emphasis Panel/Scientific Review Group 2009/05 ZRG1 ONC-S (02) M meeting, February 25-26, 2009.

Expert Swiss National Science Foundation. May, 2009 Member NIH/NCI Special Emphasis Panel/Scientific Review Group ZCA1 GRB-P (J1), Review

Discovery and Development PO1 applications in response to PAR09-025, Rockville. MD, October 6-7, 2009.

Reviewer FHCRC Interdisciplinary Training Grant for Predoctoral and Postdoctoral Research in Cancer and HIV/AIDS. October 30, 2009.

Member NIH/NCI Special Emphasis Panel/Scientific Review Group ZRG1 PSE-K(55)R Review application in response to OD-10-005: Recovery Act Limited Competition: NIH

Director’s Opportunity for Research in Five Thematic Areas (RC4). May, 2010. Reviewer Health Research Board, Ireland. Review application for HRB Health Research Awards

2012. Member Scientific Committee. The 28th International Papillomavirus Conference & Clinical and

Public Health Workshops. San Juan, Puerto Rico. Nov 30- Dec 6, 2012. Reviewer College of Basic Medicine, School of Medicine, Jiao Tong University, Shanghai, China.

March, 2013. Reviewer AAAS (American Association for the Advancement of Science) review of proposals on

behalf of Indo-US Science & Technology Forum (IUSSTF). April, 2014. IUSSTF was established in 2000 by the Indian and US governments in order to establish mutually beneficial bilateral collaboration in any field of science, technology, or health.

Member NIH/NIDCR Review Panel ZDE1 VH 09 in response to RFA-DE-16-004 Biological and Physiological Effects of E-cigarette Aerosol Mixtures (R01) and RFA-DE-16-005 Biological and Physiological Effects of E-cigarette Aerosol Mixtures (R21). Bethesda, Maryland. November 16, 2015.

PUBLICATIONS: INVITED REVIEW, BOOK CHAPTER AND SUBMISSION TO HGVbase Chen C. Risk of prostate cancer in relation to polymorphisms of metabolic genes [review]. Epidemiol Rev, 23:30–35, 2001. Cook LS, Doherty JA, Weiss NS, Chen C. Endometrial Cancer: Epidemiology and Molecular Endocrinology. Hormones, Genes, and Cancer (Henderson BE, Ponder B, Ross RK, eds). Oxford University Press, New York, NY. p. 371–397, 2003. Submission to HGVbase based on a publication on CYP2D6: “Chen C, Cook L, Li XY, Hallagan S, Madeleine MM, Daling JR, Weiss NS. CYP2D6 polymorphism and the risks of anal and vulvar cancer. Cancer Epidemiol Biomarkers Prev, 8:317–321, 1999.”, 2002. Chen C, Doherty JA. Genetic influences on the incidence of endometrial cancer. Molecular Epidemiology of Cancers (Sobti RC ed). Kluwer Academic Publishers, Netherlands. Submitted, August, 2002. Cook LS, Weiss NS, Doherty JA, Chen C. Endometrial Cancer, in Cancer Epidemiology and Prevention, 3rd Edition, D Schottenfeld and JF Fraumeni Jr, eds. Oxford, New York, 2006. JOURNAL ARTICLES 1. Erkelens DW, Chen C, Mitchell CD, Glomset JA. Studies of the interaction between apolipoproteins A

and C and triglycerol–rich particles. Biochem Biophys Acta. 1981; 665(2):221–233. PMID: 7284422.

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2. Chen C, Applegate KA, King WC, Glomset JA, Norum KR, Gjone E. A study of the small spherical high density lipoproteins of patients afflicted with familial lecithin:cholesterol acyltransferase deficiency. J Lipid Res.1984; 25(3):269–82. PMID: 6726080. http://www.jlr.org/cgi/reprint/25/3/269,

3. Chen C, Fenderson BA, Andrews WP, Hakomori S–I. Glycolid–glycosyltransferases in human embryonal

carcinoma cells during retinoic acid–induced differentiation. Biochemistry. 1989; 28(5):2229–38. PMID: 2497776.

4. Chen C, Biegalke BJ, Eisenman RN, Linial ML. FH3: a v–myc avian retrovirus with limited transforming

ability. J Virol. 1989; 63(12):5092–100. PMID: 2555545, PMCID: PMC251171. http://jvi.asm.org/cgi/reprint/63/12/5092

5. Chen C, Roby PV, Weiss NS, Wilson JA, Benedetti TJ, Tait JF. Clinical evaluation of the NBD–PC

fluorescence polarization assay for prediction of fetal lung maturity. Obstet Gynecol. 1992; 80(4):688–92. PMID: 1407896.

6. Chen C, Malone KE, Prunty J, Daling JR. Measurement of urinary metabolites using a monoclonal EIA

kit: Assay performance and feasibility for epidemiologic studies. Cancer Epidemiol Biomarkers Prev. 1996; 5(9):727–32. PMID: 8877065. http://cebp.aacrjournals.org/cgi/reprint/5/9/727

7. Chen C, Madeleine MM, Lubinski C, Weiss NS, Tickman EW, Daling JR. Glutathione S–transferase M1

genotypes and the risk of anal cancer: A population–based case–control study. Cancer Epidemiol Biomarkers Prev. 1996; 5(12):985–91. PMID: 8959321. http://cebp.aacrjournals.org/cgi/reprint/5/12/985

8. Bigler J, Chen C, Potter JD. Determination of human NAT2 acetylator genotype by oligonucleotide

ligation assay. BioTechniques. 1997; 22(4):682-4, 686, 688 passim. PMID: 9105620. 9. Potter JD, Bigler J, Fosdick L, Bostick L, Kampman E, Chen C, Louis TA, Grambsch P. Colorectal

adenomatous and hyperplastic polyps: smoking and N–Acetyltransferase 2 polymorphisms. Cancer Epidemiol Biomarkers Prev. 1999; 8(1):69–75. PMID: 9950242. http://cebp.aacrjournals.org/cgi/content/full/8/1/69

10. Chen C, Nirunsuksiri W. Decreased expression of Glutathione S–transferase M1 in HPV 16–transfected

human cervical keratinocytes in culture. Carcinogenesis. 1999; 20(4):699–703. PMID: 10223202. http://carcin.oxfordjournals.org/cgi/content/full/20/4/699

11. Chen C, Cook L, Li XY, Hallagan S, Madeleine MM, Daling JR, Weiss NS. CYP2D6 genotype and the

incidence of anal and vulvar cancer. Cancer Epidemiol Biomarkers Prev. 1999; 8(4 Pt 1):317–21. PMID: 10207635. http://cebp.aacrjournals.org/cgi/content/full/8/4/317

12. Chen C, Madeleine MM, Weiss NS, Daling JR. Glutathione S-transferase M1 genotypes and the risk of

vulvar cancer: a population-based case-control study. Am J Epidemiol. 1999; 150(5):437–42. PMID: 10472942. http://aje.oxfordjournals.org/cgi/reprint/150/5/437

13. Chen C, Madeleine MM, Weiss NS, Daling JR. Glutathione S-transferase M1 genotypes and the risk of

squamous carcinoma of the cervix: a population-based case-control study. Am J Epidemiol. 1999; 150(6):568–72. PMID: 10489995. http://aje.oxfordjournals.org/cgi/reprint/150/6/568

14. Nazar-Stewart V, Vaughan TL, Burt RD, Chen C, Berwick M, Swanson GM. Glutathione S-Transferase

M1 and susceptibility to nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 1999; 8(6):547–51. PMID: 10385146. http://cebp.aacrjournals.org/cgi/content/full/8/6/547

15. Satia JA, Patterson RE, Herrero R, Fan J, Dai Q, King I, Chen C, Kristal AR, Prentice RL, Rossing MA.

Study of diet, biomarkers and cancer risk in the United States, China and Costa Rica. Int J Cancer.

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1999; 82(1):28–32. PMID: 10360816. http://www3.interscience.wiley.com/cgi-bin/fulltext/66500368/PDFSTART

16. Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y,

Potter JD. Colorectal adenomas and the C667T MTHFR polymorphism: Evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev. 1999; 8(8):659–68. PMID: 10744125. http://cebp.aacrjournals.org/cgi/reprint/8/8/659

17. Ulrich CM, Kampman E, Bigler J, Schwartz S, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y,

Potter JD. Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps. Cancer Epidemiol Biomarkers Prev. 2000; 9(4):427–33. PMID: 10794488. http://cebp.aacrjournals.org/cgi/content/full/9/4/427

18. Crump C, Chen C, Appelbaum FR, Kopecky KJ, Schwartz SM, Willman CL, Slovak ML, Weiss NS.

Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia. Cancer Epidemiol Biomarkers Prev. 2000; 9(5):457–60. PMID: 10815689. http://cebp.aacrjournals.org/cgi/content/full/9/5/457

19. Lampe JW, King IB, Li S, Grate MT, Barale KV, Chen C, Feng Z, Potter JD. Brassica vegetables

increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis. 2000; 21(6):1157–62. PMID: 10837004. http://carcin.oxfordjournals.org/cgi/reprint/21/6/1157

20. Lampe JW, Chen C, Li S, Prunty J, Grate MT, Meehan DE, Barale KV, Dightman DA, Feng Z, Potter JD.

Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev. 2000; 9(8):787–9. PMID: 1052095. http://cebp.aacrjournals.org/cgi/reprint/9/8/787

21. White E, Kristal AR, Shikany JM, Wilson AC, Chen C, Mares-Perlman JA, Masaki KH, Caan BJ.

Correlates of serum alpha- and gamma-tocopherol in the Women's Health Initiative. Annals Epidemiol. 2001; 11(2):136–44. PMID: 11164130.

22. Lampe JW, Skor HE, Li S, Wähälä K, Howald WN, Chen C. Wheat bran and soy protein feeding do not

alter urinary excretion of the isoflavan equol in premenopausal women. J Nutr. 2001; 131(3):740–4. PMID: 11238753. http://jn.nutrition.org/cgi/reprint/131/3/740

23. Hsing AW, Chen C, Chokkalingam AP, Gao Y–T, Dightman DA, Nguyen HT, Deng J, Cheng J,

Sesterhenn IA, Mostofi FK, Stanczyk FZ, Reichardt JKV. Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2001; 10(10):1077–8. PMID: 11588134. http://cebp.aacrjournals.org/cgi/reprint/10/10/1077

24. Davis S, Kaune WT, Mirick DK, Chen C, Stevens RG. Residential magnetic fields, light-at-night, and

nocturnal urinary 6-sulphatoxymelatonin concentration in women. Am J Epidemiol. 2001; 154(7):591–600. PMID: 11581092. http://aje.oxfordjournals.org/cgi/reprint/154/7/591

25. Schwartz SM, Doody DR, Fitzgibbons ED, Ricks S, Porter PL, Chen C. Oral squamous cell cancer risk in

relation to alcohol consumption and alcohol dehydrogenase-3 genotypes Cancer Epidemiol Biomarkers Prev. 2001; 10(11):1137–44. PMID: 11700261. http://cebp.aacrjournals.org/cgi/reprint/10/11/1137

26. Chen C, Ricks S, Doody DR, Fitzgibbons ED, Porter PL, Schwartz SM. N-acetyltransferase 2

Polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk. Carcinogenesis. 2001; 22(12):1993–9. PMID: 11751430. http://carcin.oxfordjournals.org/cgi/content/full/22/12/1993

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27. Atkinson C, Skor HE, Fitzgibbons ED, Scholes D, Chen C, Wähälä K, Schwartz SM, Lampe JW. Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake. Cancer Epidemiol Biomarkers Prev. 2002; 11(3):253–60. [Erratum appears in Cancer Epidemiol Biomarkers Prev. 2002; 11(11):1511] PMID: 11895874. http://cebp.aacrjournals.org/cgi/reprint/11/3/253 Correction in: http://cebp.aacrjournals.org/cgi/reprint/11/11/1511

28. Mendez E, Cheng C, Farwell G, Agoff SN, Futran N, Weymuller EA Jr., Maronian N, Zhao LP, Chen C.

Transcriptional expression profiles of oral squamous cell carcinomas. Cancer. 2002; 95(7):1482–94. PMID: 12237917. http://www3.interscience.wiley.com/cgi–bin/fulltext/98516961/PDFSTART

29. Chen C, Lamharzi N, Weiss NS, Etzioni R, Dightman DA, Barnett M, DiTommaso D, Goodman G.

Androgen receptor polymorphisms and the incidence of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2002; 11(10 Pt 1):1033–40. PMID: 12376504. http://cebp.aacrjournals.org/cgi/reprint/11/10/1033

30. Lamharzi N, Johnson MM, Goodman G, Etzioni R, Weiss NS, Dightman DA, Barnett M, DiTommaso D,

Chen C. Polymorphic markers in the 5α–reductase type II gene and the incidence of prostate cancer. Int J Cancer. 2003; 105(4):480–3. PMID: 12712437. http://www3.interscience.wiley.com/cgi-bin/fulltext/104084186/PDFSTART

31. Goodman GE, Schaffer S, Omenn GS, Chen C, King I, CARET Co–Investigators. The association

between lung and prostate cancer risk and serum micronutrients: Results and lessons learned from β-carotene and retinol efficacy trial. Cancer Epidemiol Biomarkers Prev. 2003; 12(6):518–26. PMID: 12814997. http://cebp.aacrjournals.org/cgi/reprint/12/6/518

32. Adams KF, Newton KM, Chen C, Emerson SS, Potter JD, White E, Lampe JW. Soy isoflavones do not

modulate circulating insulin-like growth factor concentrations in an older population in an intervention trial. J Nutr. 2003; 133(5):1316–9. PMID: 12730416. http://jn.nutrition.org/cgi/reprint/133/5/1316

33. Atkinson C, Skor HE, Fitzgibbons ED, Scholes D, Chen C, Wähälä K, Schwartz SM, Lampe JW. Urinary

Equol Excretion in Relation to 2-Hydroxyestrone and 16α-Hydroxyestrone Concentrations: an Observational Study of Young to Middle-Aged Women. J Steroid Biochem Mol Biol. 2003; 86(1):71–7. PMID: 12943746. http://www.sciencedirect.com/science/article/pii/S0960076003002590

34. Chen C, Weiss NS, Stanczyk FZ, Lewis SK, DiTommaso D, Etzioni R, Barnett MJ, Goodman GE.

Endogenous sex hormones and prostate cancer risk: A case-control study nested within the Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev. 2003; 12(12):1410–6. PMID: 14693730. http://cebp.aacrjournals.org/cgi/reprint/12/12/1410

35. Kuo WP, Mendez E, Chen C, Whipple ME, Farwell G, Agoff N, Park PJ. Functional relationships

between gene pairs in oral squamous cell carcinoma. AMIA Annu Symp Proc. 2003:371–375. PMID: 14728197, PMCID: PMC1479982. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1479982&blobtype=pdf

36. Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, Caporaso N, Chen C, Coutelle C, Diehl SR, Hayes RB, Olshan AF, Schwartz SM, Sturgis EM, Wei Q, Zavras AI, Benhamou S. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am J Epidemiol. 2004; 159(1):1–16. PMID: 14693654. http://aje.oxfordjournals.org/cgi/content/reprint/159/1/1

37. Chlebowski RT, Wactawski-Wende J, Ritenbaugh C, Hubbell FA, Ascensao J, Rodabough RJ,

Rosenberg CA, Taylor VM, Harris R, Chen C, Adams-Campbell LL, White E. Estrogen Plus Progestin and Colorectal Cancer in Postmenopausal Women. New Engl J Med. 2004; 350(10):991–1004. PMID: 14999111. http://content.nejm.org/cgi/reprint/350/10/991.pdf

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38. Adams KF, Chen C, Newton KM, Potter JD, Lampe JW. Soy isoflavones do not modulate prostate-specific antigen (PSA) concentrations in older men in a randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2004; 13(4):644–8. PMID: 15066931.http://cebp.aacrjournals.org/cgi/reprint/13/4/644

39. Rosenblatt KA, Daling JR, Chen C, Sherman KJ, Schwartz SM. Marijuana use and risk of oral squamous

cell carcinoma. Cancer Res. 2004; 64(11):4049–54. PMID: 15173020. http://cancerres.aacrjournals.org/cgi/reprint/64/11/4049

40. Whipple ME, Mendez E, Farwell DG, Agoff SN, Chen C. A log likelihood predictor for genomic

classification of oral cancer using principle component analysis for feature selection. Stud Health Technol Inform. 2004; 107(Pt 2):823-6. PMID: 15360927. http://ebooks.iospress.nl/publication/21101

41. Whipple ME, Mendez E, Farwell DG, Agoff SN, Chen C. A genomic predictor of oral squamous cell

carcinoma. Laryngoscope. 2004; 114(8):1346–54.PMID: 15280706. http://onlinelibrary.wiley.com/doi/10.1097/00005537-200408000-00006/abstract;jsessionid=541A0BDA7D0124B78CE4767C9EFEC9BB.f03t03

42. Chen C, Lewis SK, Voigt L, Fitzpatrick A, Plymate SR, Weiss NS. Prostate carcinoma incidence in

relation to prediagnostic circulating levels of insulin–like growth factor I, insulin-like growth factor binding protein 3, and insulin. Cancer. 2005; 103(1):76–84. PMID: 15540247. http://www3.interscience.wiley.com/cgi-bin/fulltext/109792446/PDFSTART

43. Doherty JA, Weiss NS, Freeman RJ, Dightman DA, Thornton PJ, Houck JR, Voigt, LF, Rossing MA,

Schwartz SM, Chen C. Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer. Cancer Epidemiol Biomarkers Prev. 2005; 14(2):357–66. PMID: 15734958. http://cebp.aacrjournals.org/cgi/content/full/14/2/357

44. Johnson MM, Houck J, Chen C. Screening for deleterious nonsynonymous single-nucleotide

polymorphisms in genes involved in steroid hormone metabolism and response. Cancer Epidemiol Biomarkers Prev. 2005; 14(5):1326–9. PMID: 15894696. http://cebp.aacrjournals.org/cgi/reprint/14/5/1326

45. Huang W-Y, Olshan AF, Schwartz SM, Berndt SI, Chen C, Llaca V, Chanock SJ, Fraumeni JF Jr.,

Hayes RB. Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis. Cancer Epidemiol Biomarkers Prev. 2005; 14(7):1747–53. PMID: 16030112. http://cebp.aacrjournals.org/cgi/reprint/14/7/1747

46. Starr JR, Chen C, Doody DR, Hsu L, Ricks S, Weiss NS, Schwartz SM. Risk of testicular germ cell

cancer in relation to variation in maternal and offspring cytochrome P450 genes involved in catechol estrogen metabolism. Cancer Epidemiol Biomarkers Prev. 2005; 14(9):2183–90. PMID: 16172230. http://cebp.aacrjournals.org/cgi/reprint/14/9/2183

47. Choi P and Chen C. Genetic expression profiles and biologic pathway alterations in head and neck

squamous cell carcinoma. Cancer. 2005; 104(6):1113–28. [Erratum in Cancer. 2005; 104(11):2532.] PMID: 16092115. http://www3.interscience.wiley.com/cgi–bin/fulltext/110578760/PDFSTART Correction in: http://www3.interscience.wiley.com/cgi–bin/fulltext/112133983/PDFSTART

48. Nathanson KL, Kanetsky PA, Hawes R, Letrero R, Dudakia D, Vaughn DJ, Johnson L, Robertson K,

Tucker K, Friedlander M, Phillips K-A, Hogg D, Jewett MAS, Lohynska R, Daugaard G, Richard S, Chompret A, Bonaïti-Pellié C, Heidenreich A, Olah E, Geczi L, Bodrogi I, Ormiston WJ, Daly PA, Oosterhuis JW, Gillis AJM,

Leendert HJ, Looijenga LHJ, Guilford P, Fosså SD, Heimdal K, Tjulandin SA,

Liubchenko L, Stoll H, Weber W, Rudd M, Huddart R, Crockford GP, Forman D, Oliver DT, Einhorn L, Weber BL, Kramer J, McMaster M, Greene MH, Pike M, Cortessis V, Chen C, Schwartz SM, Bishop DT, Easton DF, Stratton MR, Rapley EA. The Y deletion gr/gr and susceptibility to testicular germ cell tumor.

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Am J Hum Genet. 2005; 77(6):1034–43. PMID: 16380914, PMCID: PMC1285161. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1285161&blobtype=pdf

49. Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Voigt LF, Chen C. Interindividual variation in nucleotide

excision repair genes and risk of endometrial cancer. Cancer Epidemiol Biomarkers Prev. 2005; 14(11 Pf 1):2524–3. PMID: 16284373. http://cebp.aacrjournals.org/cgi/content/full/14/11/2524

50. Modugno F, Ness RB, Chen C, Weiss NS. Inflammation and endometrial cancer: A hypothesis. Cancer

Epidemiol Biomarkers Prev. 2005; 14(12):2840–7. PMID:16364998. http://cebp.aacrjournals.org/cgi/reprint/14/12/2840

51. Gal TJ, Huang W-Y, Chen C, Hayes RB, Schwartz SM. DNA repair gene polymorphisms and risk of

second primary neoplasms and mortality in oral cancer patients. Laryngoscope. 2005; 115(12):2221–31. PMID: 16369171. http://onlinelibrary.wiley.com/doi/10.1097/01.mlg.0000183736.96004.f7/abstract

52. Chen C, Doherty JA, Lewis SK, Ray RM, Gao DL, Stalsberg H, Feng Z, Thomas DB. Insulin-like growth

factor -I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women. Int J Cancer. 2006; 118(9):2303–9. PMID: 16331609. http://www3.interscience.wiley.com/cgi–bin/fulltext/112167475/PDFSTART

53. Atkinson C, Lampe JW, Scholes D, Chen C, Wähälä K, Schwartz SM. Lignan and isoflavone excretion in

relation to uterine fibroids: a case-control study of young to middle-aged women in the United States. Am J Clin Nutr. 2006; 84(3):587–93. PMID: 16960173. http://www.ajcn.org/cgi/content/full/84/3/587

54. Weiss JM, Saltzman BS, Doherty JA, Voigt LF, Chen C, Beresford SA, Hill DA, Weiss NS. Risk Factors

for the incidence of endometrial cancer according to the aggressiveness of disease. Am J Epidemiol. 2006; 164(1):56–62. PMID: 16675538. http://aje.oxfordjournals.org/cgi/content/full/164/1/56

55. McTiernan A, Wu L, Chen C, Chlebowski R, Mossavar-Rahmani Y, Modugno F, Perri MG, Stanczyk FZ,

Van Horn L, Wang CY, WHI Investigators. Relation of BMI and Physical Activity to Sex Hormones in Postmenopausal Women. Obesity. 2006; 14(9):1662–77. PMID: 17030978. http://www.nature.com/oby/journal/v14/n9/full/oby2006191a.html

56. Davis S, Mirick DK, Chen C, Stanczyk FZ. Effects of 60-Hz magnetic field exposure on nocturnal 6-

sulphatoxymelatonin, estrogens, luteinizing hormone and follicle stimulating hormone in healthy reproductive-age women: Results of a cross-over trial. Ann Epidemiol. 2006; 16(8):622–31. PMID: 16458540. http://www.sciencedirect.com/science/article/pii/S1047279705003820

57. Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Chen C. Nucleotide excision repair genotype and the

incidence of endometrial cancer: Effect of other risk factors on the association. Gynecol Oncol. 2006; 103(3):891–6. PMID: 16806437. http://www.sciencedirect.com/science/article/pii/S0090825806004288

58. Chen YJ, Chen C, Wu DC, Lee CH, Wu CI, Lee JM, Goan YG, Huang SP, Lin CC, Li T-C, Chou YP, Wu MT. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. Int J Cancer. 2006; 119(12):2827–31. PMID: 17036331. http://onlinelibrary.wiley.com/doi/10.1002/ijc.22199/abstract

59. Chen C, Freeman R, Voigt LF, Fitzpatrick A, Plymate SR, Weiss NS. Prostate cancer risk in relation to

selected genetic polymorphisms in insulin-like growth factor-1, insulin-like growth factor binding protein 3, and insulin–like growth factor-1 receptor. Cancer Epidemiol Biomarkers Prev. 2006; 15(12):2461–6. PMID: 17164371. http://cebp.aacrjournals.org/cgi/reprint/15/12/2461

60. Holt SK, Rossing MA, Malone KE, Schwartz SM, Weiss NS, Chen C. Ovarian cancer risk and

polymorphisms involved in estrogen catabolism. Cancer Epidemiol Biomarkers Prev. 2007; 16(3):481–9. PMID: 17372243. http://cebp.aacrjournals.org/cgi/reprint/16/3/481

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61. Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Maso LD, Daudt AW, Fabianova E, Wünsch-Filho V, Franceschi S, Hayes R, Herrero R, Koifman S, Vecchia CL, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf–Neto J, Olshan A, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Zhang Z-F, Berthiller J, Boffetta P. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology consortium. JNCI. 2007; 99(10):777–89. PMID: 17505073. http://jnci.oxfordjournals.org/cgi/reprint/99/10/777

62. Mendez E, Fan W, Choi P, Agoff SN, Whipple M, Farwell DG, Futran ND, Weymuller EA Jr, Zhao LP,

Chen C. Tumor-specific genetic expression profile of metastatic oral squamous cell carcinoma. Head Neck. 2007; 29(9):803–14. PMID: 17573689. http://onlinelibrary.wiley.com/doi/10.1002/hed.20598/abstract

63. Siahpush SH, Vaughan TL, Lampe JW, Freeman R, Lewis SK, Odze RD, Blount PL, Ayub K,

Rabinovitch PS, Reid BJ, Chen C. Longitudinal study of insulin-like growth factor-I, insulin-like growth factor binding protein-3, and their polymorphisms: Risk of neoplastic progression in Barrett's Esophagus. Cancer Epidemiol Biomarkers Prev. 2007; 16(11):2387–95. PMID: 18006928. http://cebp.aacrjournals.org/cgi/reprint/16/11/2387

64. Doherty JA, Cushing-Haugen KL, Saltzman BS, Voigt LF, Hill DA, Beresford SA, Chen C, Weiss NS.

Long-term use of postmenopausal estrogen and progestin hormone therapies and risk of endometrial cancer. Am J Obstet Gynecol. 2007; 197(2):139.e1–7. PMID: 17689625. http://www.sciencedirect.com/science/article/pii/S0002937807000907

65. McTiernan A, Wu L, Barnabei VM, Chen C, Hendrix S, Mudugno F, Rohan T, Stanczyk FZ, Wang CY.

Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women. Breast Cancer Res Treat. 2008; 108(2):217–31. PMID: 18297397. http://rd.springer.com/article/10.1007%2Fs10549-007-9588-6

66. Saltzman BS, Doherty JA, Hill DA, Beresford SA, Voigt LF, Chen C, Weiss NS. Diabetes and endometrial

cancer: An evaluation of the modifying effects of other known risk factors. Am J Epidemiol. 2008; 167(5):607–14. PMID: 18071194. http://aje.oxfordjournals.org/cgi/reprint/167/5/607

67. Sakoda LC, Blackston CR, Xue K, Doherty JA, Ray RM, Lin MG, Stalsberg H, Gao DL, Feng Z, Thomas

DB, Chen C. Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. Breast Cancer Res Treat. 2008; 109(1):143–55. PMID: 17624589, PMCID: PMC2741390. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741390/pdf/nihms90962.pdf

68. Roddam A, Allen N, Appleby P, Key T, Dorgan J, Albanes D, Taylor P, Ferrucci L, Carter HB, Metter EJ,

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Morgenstern H, Chen C, Schwartz SM, Vaughan T, Wunsch-Filho V, Purdue M, Koifman S†, Curado MP, Vilensky M, Gillison M, Fernandez L, Menezes A, Daudt AW, Schantz S, Yu G, D’Souza G, Haddad RI, La Vecchia C, Hashibe M. Mouthwash use and cancer of the head and neck: a pooled analysis of data from the International Head and Neck Cancer Epidemiology Consortium. Eur J Cancer Prev. 2015 Aug 13. [Epub ahead of print]. PMID: 26275006, PMCID: PMC4752930. http://pt.wkhealth.com/pt/re/lwwgateway/landingpage.htm;jsessionid=WsjJSfBZvhNvLBJWtfyzLGxgJG1Y9qGkn8NTjJwRKn2b8rMDy4W6!-396536289!181195628!8091!-1?sid=WKPTLP:landingpage&an=00008469-900000000-99475

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188. Wyss AB, Hashibe M, Lee Y-C, Chuang SC, Muscat J, Chen C, Schwartz SM, Smith E, Zhang Z-F,

Morgenstern H, Sturgis EM, Li G, Kelsey K, McClean M, Winn DM, Schantz S, Yu GP, Gillison M, Zevallos JP, Boffetta P, Olshan AF. Smokeless tobacco use and the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Am J Epidemiol. In press.

189. Travis RC, Appleby PN, Martin RM, Holly JM, Albanes D, Black A, Bueno-de-Mesquita HB, Chan JM,

Chen C, Chirlaque MD, Cook MB, Deschasaux M, Donovan JL, Ferrucci L, Galan P, Giles GG, Giovannucci E, Gunter MJ, Habel LA, Hamdy FC, Helzlsouer KJ, Hercberg S, Hoover RN, Janssen JA, Kaaks R, Kubo T, Le Marchand L, Metter EJ, Mikami K, Morris JK, Neal DE, Neuhouser ML, Ozasa K,

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Palli D, Platz EA, Pollak MN, Price AJ, Roobol MJ, Schaefer C, Schenk JM, Severi G, Stampfer MJ, Stattin P, Tamakoshi A, Tangen CM, Touvier M, Wald NJ, Weiss NS, Zeigler RG, Key TJ and Allen NE; Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. A meta-analysis of individual participant data reveals an association between circulating levels of IGF-1 and prostate cancer risk. Cancer Res. 2016 Apr 15;76(8):2288-300. doi: 10.1158/0008-5472.CAN-15-1551. Epub 2016 Feb 26. PMID: 26921328. http://cancerres.aacrjournals.org/content/76/8/2288.long

190. Chen MM, O'Mara TA, Thompson DJ, Painter JN, The Australian National Endometrial Cancer Study

Group (ANECS), Attia J, Black A, Brinton L, Chanock S, Chen C, Chen C, Cheng THT, Cook LS, Crous-Bou M, Doherty J, Friedenreich CM, Garcia-Closas M, Gaudet MM, Gorman M, Haiman C, Hankison SE, Hartge P, Henderson BE, Hodgson S, Holliday EG, Horn-Ross PL, Hunter DJ, Le Marchand L, Liang X, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, National Study of Endometrial Cancer Genetics Group (NSECG), Olson SH, Orlow I, Pooler L, Prescott J, Rastogi R, Rebbeck TR, Risch H, Sacerdote C, Schumacher F, Setiawan VW, Scott RJ, Sheng X, Shu X-O, VanDen Berg D, Weiss NS, Wentzensen N, Xia L, Xiang Y-B, Yang HP, Yu H, Zhang W, Pharoah PDP, Dunning AM, Tomlinson I, Easton DF, Kraft P, Spurdle AB, De Vivo I. GWAS meta-analysis of 16,852 women identifies new susceptibility locus for endometrial cancer. Human Mol Genet. 2016 Mar 23. pii: ddw092. [Epub ahead of print]. PMID: 27008869. http://www.ncbi.nlm.nih.gov/pubmed/27008869

191. Price AJ, Travis RC, Appleby PN, Albanes D, Gurrea AB, Bjørge T, Bueno-de-Mesquita H.B(as), Chen C, Donovan J, Gislefoss R, Goodman G, Gunter M, Hamdy FC, Johansson M, King IB, Kühn T, Männistö S, Martin RM, Meyer K, Neal DE, Neuhouser ML, Nygård O, Stattin P, Tell GS, Trichopoulos A, Tumino R, Ueland PM, Ulvik A, de Vogel S, Vollset SE, Weinstein SJ, Key TJ and Allen NE; Nutritional Biomarkers and Prostate Cancer Collaborative Group. Circulating folate and vitamin B12 and risk of prostate cancer: an individual participant data pooled analysis of 6875 cases and 8104 controls from six cohort studies. Eur Urology 2016 Apr 6. pii: S0302-2838(16)00379-1. doi: 10.1016/j.eururo.2016.03.029. [Epub ahead of print], PMID: 27061263. http://www.sciencedirect.com/science/article/pii/S0302283816003791

192. Machiela MJ, Zhou W, Karlins E, Sampson JN, Freedman ND, Yang Q, Hicks B, Dagnall C, Hautman C1,

Jacobs KB, Abnet CC, Aldrich MC, Amos C, Amundadottir LT, Berndt SI, Black A, Blot WJ, Bock CH, Bracci PM, Brinton LA, Burdett L, Buring JE, Butler MA, Carreón T, Chang I-S, Chatterjee N, Chen C, Chen C, Chen K, Chung CC, Cook LS, Bou MC, Cullen M, Davis FG, De Vivo I, Ding T, Doherty J, Duell EJ, Epstein CG, Fan J-H, Figueroa J-D, Fraumeni JF Jr., Friedenreich CM, Fuchs CS, Gao Y-T, Gapstur SM, Garcia-Closas M, Gaudet MM, Gaziano JM, Giles GG, Gillanders EM, Giovannucci EL, Goldin L, Goldstein AM, Haiman CA, Hallmans G, Hankinson SE, Harris CC, Henriksson R, Holly EA, Hong Y-C, Hoover RN, Hsiung CA, Hu N, Hu W, Hunter DJ, Hutchinson A, Jenab M, Johansen C, Khaw K-T, Kim HN, Kim YH, Kim YT, Klein R, Koh W-P, Kolonel LN, Kooperberg C, Kraft P, Krogh V, Kurtz RC, LaCroix A, Lan Q, Landgren A, Landi MT, Le Marchand L, Li D, Liang X, Liao LM, Lin D, Liu J, Lissowska J, Lu L, Magliocco AM, Malats N, Matsuo K, McNeill LH, McWilliams RR, Melin BS, Mirabello L, Moore L, Olson SH, Orlow I, Park JY, Patiño-Garcia A, Peplonska B, Peters U, Petersen GM, Pooler L, Prescott J, Prokunina-Olsson L, Purdue M, Qiao Y-L, Rabe KG, Rajaraman P, Real FX, Riboli E, Risch HA, Rodriguez-Santiago B, Ruder AM, Savage SA, Schumacher F, Schwartz AG, Schwartz KL, Seow A, Sesso HD, Setiawan VW, Severi G, Shen H, Sheng X, Shin M-H, Shu X-O, Silverman DT, Spitz MR, Stevens VL, Stolzenberg-Solomon R, Stram D, Tang Z-Z, Taylor PR, Teras LR, Tobias GS, VanDen Berg D, Viswanathan K, Wacholder S, Wang J-C, Wang Z, Wentzensen N, Wheeler W, White E, Wiencke JK, Wolpin BM, Wong MP, Wu C, Wu T, Wu X, Wu Y-L, Wunder JS, Xia L, Yang HP, Yang P-C, Yu K, Zanetti KA, Zeleniuch-Jacquotte A, Zheng W, Zhou B, Ziegler RG, Perez-Jurado LA, Caporaso NE, Rothman N, Tucker M, Dean MC, Yeager M, Chanock SJ. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome. Nature Commun 2016 Jun 13;7:11843. doi: 10.1038/ncomms11843. PMID: 27291797, PMCID: PMC4909985 http://www.nature.com/articles/ncomms11843

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193. Hashim D, Wu H, Sartori S, Brennan P, Curado MP, Vilensky M, Fernandez L, Menezes A, Daudt AW, Wünsch-Filho V, Olshan AF, Zevallos JP, Winn DM, Franceschi S, Herrero R, Castellsague X, Fabianova E, Lissowska J, Mates D, Rudnai P, Shangina O, Szeszenia-Dabrowska N, Zhang Z-F, Morgenstern H, Chen C, Schwarz SM, Vaughan T, Hayes RB, Hofmann J, Gillison M, Schantz S, Yu G-P, D'Souza G, Haddad RI, Lee Y-C A, Hashibe M, La Vecchia C, Boffetta P. Oral hygiene and the role in head and neck cancer: Results from International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Ann Oncol. 2016 Aug;27(8):1619-25. doi: 10.1093/annonc/mdw224. Epub 2016 May 27. PMID: 27234641, PMCID: PMC4959929. http://annonc.oxfordjournals.org/content/27/8/1619.long

194. Biggs ML, Doody DR, Trabert BL, Starr JR, Chen C, Schwartz SM. Consumption of alcohol in

adolescence and adulthood and risk of testicular germ cell tumor. Int J Cancer. 2016 Jul 30. doi: 10.1002/ijc.30368. [Epub ahead of print]. PMID: 27474852.

195. Jung SY, Barrington WE, Lane DS, Chen C, Chlebowski R, Corbie-Smith G, Hou L, Zhang Z-F, Paek MS, Crandall CJ. Bioavailable Insulin-Like Growth Factor-I as Mediator of Racial Disparity in Obesity-Relevant Breast and Colorectal Cancer Risk among Postmenopausal Women. Menopause. In press.

JOURNAL ARTICLES SUBMITTED OR IN PREPARATION 1. Lohavanichbutr P, Sakoda LC, Julianto L, Barnett MJ, Thornquist MD, Weiss NS, Goodman GE, Chen

C. Polymorphic variation in selected drug metabolism genes in relation to lung cancer survival among cigarette smokers. Lung Cancer. Under Revision.

2. Prescott J, Setiawan VW, Wentzensen N, Schumacher F, Yu H, Delahanty R, Chanock S, Chen C,

Cook LS, Friedenreich C, Garcia-Closas M, Haiman CA, Hartge P, Horn-Ross P, Le Marchand L, Lissowska J, Lu L, Magliocco AM, Olson S, Risch HA, Shu X-O, Ursin G, Weiss NS, Yang H, Kraft P, De Vivo I. Body mass index genetic risk scores and endometrial cancer risk. Am J Obstet Gynecol. 2015. Submitted.

3. Brenner DR, Amos CI, Brhane Y, Timofeeva MN, Caporaso N, Wang Y, Christiani DC, Bickeboller H,

Yang P, Albanes D, Gapstur S, McKay J, Boffetta P, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Broderick P, Eisen T, Wu X, Zhang D, Chen W, Spitz MR, Wei Y, Su L, Matsuo K, Matsuda F, Ito H, Risch A, Heinrich J, Rosenberger A, Muley T, Dienemann H, Field JK, Raji O, Chen Y, Gosney J, Liloglou T, McLaughlin J, Orlow I, Zakowski M, Han Y, Li Y, Zong X, Johansson M and EPIC Investigators, Liu G, Tworoger S, Le Marchand L, Henderson BE, Wilkens LR, Dai J, Shen H, Houlston R, Landi MT, Brennan P, Hung RJ. Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis. 2015. Submitted.

4. Langeberg WJ, Doherty JA, Voigt LF, Rossing MA, Saltzman BS, Beresford SA, Hill DA, Chen C, Weiss

NS. Obesity and endometrial cancer: the effect of other risk factors on the relationship. Epidemiol. 2014. Submitted.

5. Kachuri L, Amos CI, McKay JD, LeMarchand L, Goodman G, Chen C, Doherty JA, Christiani DC,

Tworoger S, Field JK, Caporaso NE, Severi G, Liu G, McLaughlin JR, Li Y, Fehringer G, Zong X, Denroche RE, Zuzarte PC, McPherson JD, Brennan P, Hung RJ. Fine-mapping of chromosome 5p15.33 based on a targeted deep sequencing identifies novel lung cancer susceptibility loci. Carcinogenesis, 2015. Submitted.

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6. Carreras-Torres R, Haycock PC, Relton CL, Martin RM, Smith GD, Kraft P, Gao C, Tworoger S, Le Marchand L, Wilkens LR, Park SL, Haiman C, Field JK, Davies M, Marcus M, Liu G, Caporaso NE, Christiani DC, Wei Y, Chen C, Doherty JA, Severi G, Goodman GE, Hung RJ, Amos CI, McKay J, Johansson M, Brennan P. The causal relevance of body mass index in different histological types of lung cancer. A Mendelian randomization study. Am J Epidemiol. 2016. Submitted.

7. McKay JD, Hung R, Han Y, Zong X, Bossé Y, Carreras-Torres R, Xiao X, Li Y, Qian DC, Beesley J,

Chenevix-Trench G, McLaughlin J, Rafnar T, Houlston R, Lamontagne M, Joubert P, Obeidat M, Timens W, Nickle DC, Zhu B, Song L, Artigas MS, Tobin M, Stefansson K, Reginsson GW, Thorgeirsson TE, Hancock DB, Gaddis NC, Lutz SM, Gu F, Baker TB, Marazita ML, Bierut LJ, Johnson EO, Byun J, Kamal A, Zhu D, Ji X, Dragnev KH, Gorlova OY, Tyndale RF, Lindstroem S, Jiang X, Albanes D, Lam S, Tsao M-S, Tardon A, Fernandez-Tardon G, Fernandez-Tardon G, Fernandez-Somoano A, Doherty JA, Barnett M, Chen C, Goodman G, Egil Bojesen S, Caporaso N, Johansson M, Manjer J, Brunnström H, Melander O, Overvad K, Field JK, Marcus MW, Davies MPA, Bickeböller H, Rosenberger A, Brüske I, Manz J, Risch A, Muley T, Christiani D, Rennert G, Arnold S, Wu X, Ye Y, Manjer J, Le Marchand L, Haiman C, Wilkens L, Liu G, Zong X, Brhane Y, Andrew A, Kiemeney LA, van der Heijden HFM, Shen H, Hu Z, Dai J, Haugen A, Zienolddiny S, Skaug V, Bakke P, Johansson M, Caporaso N, Cox A, Taylor F, Woll P, Teare MD, Scelo G, Zaridze D, Mukeria A, Kontic M, Milosavljevic S, Lissowska J, Swiatkowska B, Janout V, Holcatova I, Bolca C, Hong Y-C, Kim JH, SpiroMeta consortium, Yuan J-M, Gao Y-T, Yuan J-M, Koh W-P, Butler L-M, Lazarus P, Schabath MB, Haura EB, Aldrich MC, Bush WS, Brennan P, Landi MT, Amos CI. Characterizing the genetic architecture of lung cancer susceptibility through the Oncoarray. Nature Genetics. 2016. Submitted.

8. Brockton NT, Lohavanichbutr P, Enwere EK, Upton MP, Kornaga EN, Nakoneshny SC, Bose P, Chen C,

Dort JC. Expression of Tumoral Carbonic Anhydrase IX and Ki67 in Relation to Survival in Oral Cavity Squamous Cell Carcinoma Patients. JAMA Oncol. 2016. Submitted.

9. Li N, Hauser R, Bassig BA, Holford T, Zhu Y, Honig S, Chen C, Boyle P, Dai M, Schwartz SM, Morey P, Sayward H, Gomery P, Zheng T. Association between marijuana/hashish use and risk of non-seminoma tumor: a population-based case-control study from Connecticut and Massachusetts. In preparation.

10. Zhou F, Wang Y, Liu H, Ready N, Owzar K, Han Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Chen

C, Goodman G, Bickeböller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Heinrich J, Risch A, Ye Y, Christiani DC, Amos CI, Wei Q, Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team. Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk - a re-analysis of eight GWASs. In preparation for Carcinogenesis.

11. Luo J, Hendryx MS, Margolis K, Rohan T, Chlebowski R, Stefanick M, LeBlanc ES, Thomson C, Chen C,

Coday M, Felix _, Barrington WE, Wactawski-Wende J. Weight change and risk of endometrial cancer. In preparation.

12. Oh H, Behan S, Matthews CE, Falk RT, LeBlanc ES, Wactawski-Wende J, Sampson J, Pfeiffer R,

Brinton LA, Wentzensen N, Anderson GL, Manson JE, Chen C, Zaslavsky O, Xu X, Trabert B. Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Women’s Health Initiative Observational Study. Submitted to Breast Cancer Research.

13. Voltzke KJ, Lee A Y-C, Zhan Z-F, Zevallos JP, Yu GP, Winn DM, Vaughan TL, Sturgis EM, Smith E,

Schwartz SM, Schantz S, Muscat J, Morgenstern H, McClean M, Li G, Lazarus P, Kelsey K, Gillison M, Chen C, Boffetta P, Hashibe M, Olshan AF. Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: Pooled analysis of US studies in the INHANCE Consortium. In preparation.

Chu Chen Page 41 of 56

14. Kabat GC, Wu, W Y-Y, Bea JW, Chen C, Qi L, Stefanick ML, Chlebowski RT, Lane DS, Wactawski-Wende J, Wassertheil-Smoller S, Rohan TE. Obesity phenotypes: prevalence, correlates, and change over time in a cohort of postmenopausal women. In preparation.

15. Cooper-DeHoff RM, Garvan C, Delaney JAC, Winterstein AG, Bavry AA, Howard BV, Chen C, Manson

JE, Phillips LS, Liu S, Song Y, Shorr RI, Limacher MC. Chronic utilization of medications with adverse metabolic effects and risk for incident diabetes in postmenopausal women. J Am College Cardiol. In preparation.

16. Chang S-C, Lee Y-C A, Chuang S-C, Berthiller J, Ferro G, Matsuo K, Wünsch-Filho V, La Vecchia C,

Olshan AF, Zevallos JP, Talamini R, Muscat J, Sturgis EM, Li G, Morgenstern H, Levi F, Dal Maso L, Smith E, Kelsey K, McClean M, Vaughan T, Lazarus P, Ramroth H, Chen C, Schwartz SM, Winn D, Hayes RB, Purdue MP, Boccia S, Cadoni G, Shangina O, Koifman S, Curado MP, Benhamou S, Vilensky M, Szeszenia-Dabrowska N, Herrero R, Castellsague X, Fernandez L, Menezes A, Daudt AW, Mates D, Schantz S, Yu GP, Lissowska J, Brenner H, Fabianova E, Rudnai P, Brennan P, Boffetta P, Zhang Z-F, Hashibe M. Age at start of using tobacco and drinking alcohol on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). In preparation.

17. Adeney KL, Davis S, Mirick DK, Chen C, Williams MA. Birth weight and preterm birth in relation to adult

6-sulphatoxymelatonin excretion and chronotype. Paediatric Perinatal Epidemiol. In preparation.

18. Sakoda LC, Weiss NS, Etzioni R, Barnett M, Goodman GE, Chen C. Relation of AR CAG and GGC repeat length with levels of steroid hormones in men. In preparation.

19. Hung RJ, et al. Identification of a novel lung cancer susceptibility locus comprising the telomerease

reverse transcriptase gene among 6000 lung cancer cases and 9500 controls. In preparation.

20. Houck J, Lohavanichbutr P, Doody D, Mendez ED, Yueh B, Futran N, Schwartz SM, Chen C. Promoter hypermethylation and hypomethylation in cancer-related genes in oral squamous cell carcinoma. In preparation.

21. Winn DM, Lee Y-C A, Schwartz SM, Hashibe M, Boffetta P, on behalf of the INHANCE consortium. The

International Head and Neck Cancer Epidemiology Consortium: Towards a better understanding of behavioral, environmental and genetic risk factors for oral cavity, pharynx and larynx cancer. In preparation.

22. Gray E, … Chen C… et al. External Validation of Eight Lung Cancer Prediction Models: A Study with the

International Lung Cancer Consortium. Thorax. 2016. Submitted.

23. Sanikini H, …..Chen C, Barnett M, Goodman G, Stücker I. Body mass index and lung cancer risk: A nested case-control study. In preparation.

24. Jordan S. et al. Breast feeding and endometrial cancer risk in E2C2 studies. In preparation.

ABSTRACTS 1. Raschke K, Pierce M and Chen C. Plant Research 1973. The Michigan State University/Atomic Energy

Commission Plant Research Laboratory, p.28. 1974. 2. Raschke K, Zeevaart JAD, Pierce M and Chen C. Plant Research 1973. The Michigan State

University/Atomic Energy Commission Plant Research Laboratory, p.28. 1974.

Chu Chen Page 42 of 56

3. Chen C, Erkelens DW, Mitchell CD and Glomset JA. Interactions of apolipoproteins AI, AII and C with triglyceride–rich particles. Fed Proc, 38:309, 1979.

4. Chen C, Roby PV, Benedetti TJ and Tait JF. Amniotic fluid fluorescence polarization and lecithin to

sphingomyelin ratio as predictors for fetal lung maturity. Clin Chem, 37:919, 1991. 5. Chen C and Raisys, V. Detection of cocaine and benzoylecgonine in meconium by enzyme–multiplied

immunoassay technique (EMIT) following solid phase extraction. Clin Chem, 38:1008, 1992. 6. Chen C, Malone KE, Prunty J and Daling JR. Measurement of urinary 2–hydroxy estrone and 16α–

hydroxyestrone by the EstrametTM 2/16 enzyme–linked immunoassay. Clin Chem, 41: S36, 1995. 7. Chen C, Lubinski C, Tickman E, Madeleine M, Weiss NS, Daling JR. Glutathione S–transferase M1

genotypes and the risk of anal, vulvar and vaginal cancers. Proceedings of the American Association for Cancer Research Special Conference on Cancer Susceptibility Genes and Molecular Carcinogenesis, B64, 1996.

8. Vaughan T, Nazar–Stewart V, Chen C, Farrow DC, Burt RD, Swanson GM and Berwick M.

Nasopharyngeal cancer and GSTM1 deletion: Interaction with smoking, alcohol and diet in a population–based study. Proceedings of the American Association for Cancer Research Special Conference on Cancer Susceptibility Genes and Molecular Carcinogenesis, B39, 1996.

9. Chen C, Lee W, Prunty J. Plasma ascorbic acid: Stability and enzymatic spectrophotometric detection

with a Roche Cobas Mira Plus centrifugal analyzer. Clin Chem, 42: S301, 1996. 10. Jenkins M, Bigler J, Kampman E, Chen C, Slattery M, Leppert M, Potter J. Association between colon

cancer and acetylation (NAT1 & NAT2) genotypes in a large population–based study. Am J Epidemiol, 145:S68, 1997.

11. Ulrich C, Bigler J, Chen C, Kampman E, Schwartz S, Fosdick L, Bosdick R, Potter JD. MTHFR

polymorphism and risk of colorectal adenomatous polyps. The American Society for Cancer Research 89th Annual Meeting. Proc Am Assoc Cancer Res, 39: 39, 1998.

12. Potter JD, Bigler J, Fosdick L, Bostick R, Kampman E, Chen C, Louis T, Grambsch P. Adenomatous

polyps, red meat, smoking: the role of NAT2. The American Society for Cancer Research 89th Annual Meeting. Proc Am Assoc Cancer Res, 39: 39, 1998.

13. Chen C and Nirunsuksiri W. Down regulation of glutathione S–transferase M1 in HPV16–transfected

human cervical keratinocytes in culture. The American Association of Cancer Research Special Conference on Gene Regulation and Cancer. October 1998.

14. Schwartz SM, Fitzgibbons ED, Skor H, Scholes D, Chen C, Lampe JW. Phytoestrogens, organochlorine

compounds, and uterine leiomyomata: Preliminary results from an epidemiologic study. NIEHS Grantees’ Meeting on Endocrine Disruptors. October 1998.

15. Lampe JW, Chen C, King IB and Potter JD. Plant–food intake and glutathione S–transferase activity in

humans: Influence of GSTM1 genotype. Proceedings of Second International Conference on Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease. Page OWIII/1. Helsinki, Finland. June 1998.

16. Chen C, Cook LS, Li X–Y, Hallagan S, Madeleine MM, Daling JR and Weiss NS. CYP2D6 polymorphism

and the incidence of anal and vulvar cancer. Invited presentation. Proceedings of the Schilling Research Conference, American Cancer Society. March 1999.

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17. Schwartz S, Fitzgibbons E, Skor H, Scholes D, Chen C, Lampe J. Phytoestrogens, organochlorine compounds, and uterine leiomyomata. The American Society for Cancer Research 90th Annual Meeting. Philadelphia, PA. Proc Am Assoc Cancer Res, 40:149, 1999.

18. Lampe JW, Li S, Prunty J, Grate MT, Skor HE, Barale KV, Chen C, King IB, Feng Z, Potter JD. Serum

GST–α concentrations and GST activities in humans on controlled hashibevegetable diets. The American Society for Cancer Research 90th Annual Meeting. Philadelphia, PA. Proc Am Assoc Cancer Res, 40:213, 1999

19. Potter JD, Bigler J, Fosdick L, Bostick R, Kampman E, Chen C, Louis T, Grambsch P. Adenomatous

polyps, red meat, and smoking: the role of N–acetyl transferases. The American Society for Cancer Research 90th Annual Meeting. Philadelphia, PA. Proc. Am Assoc Cancer Res, 40:212, 1999.

20. Lampe JW, King IB, Hu X, Li S, Barale KV, Grate MT, Chen C, Feng Z, Potter JD. Cruciferous

vegetables increase and umbelliferous vegetables decrease CYP1A2 activity in humans. FASEB J., 13:A919, 1999.

21. Skor H, Schwartz S, Fitzgibbons D, Scholes K, Chen C, Wähälä K, Lampe J. Urinary isoflavone and

lignan excretion among premenopausal women in Seattle, Washington. The Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. 1999.

22. Dunn C, Schwartz S, Dightman D and Chen C. CYP17 and COMT polymorphisms and risk of uterine

leiomyomata. The American Society for Cancer Research 91st Annual Meeting. San Francisco, CA. Proc Am Assoc Cancer Res, 41:361, 2000.

23. Chen C, Ricks S, Fitzgibbons D, Doody D, Porter P, Schwartz S. Glutathione S–transferase M1 and T1

genotypes, cigarette smoking, and the risk of squamous cell cancer of the oral cavity. The American Society for Cancer Research 91st Annual Meeting. San Francisco, CA. Proc Am Assoc Cancer Res, 41:593, 2000.

24. Schwartz S, Doody D, Ricks S, Fitzgibbons D, Porter P, Chen C. ADH3 genotypes, alcohol consumption,

and oral cancer risk. The American Society for Cancer Research 91st Annual Meeting, San Francisco, CA. Proc Am Assoc Cancer Res, 41:557, 2000.

25. Schwartz S, Fitzgibbons D, Scholes K, Chen C, Lampe J. Organochlorine compounds and uterine

leiomyomata. The Society for Epidemiologic Research Annual Meeting. 2000. 26. Mendez E, Farwell G and Chen C. Genomic–scale genetic expression profiles of oral cancers. The

American Association for Cancer Research Special Conference “Oncogenomics: Dissecting Cancer through Genomics Research”. Tucson, AZ. Proc Am Assoc Cancer Res Oncogenomics Conference, p73, 2001.

27. Chen C, Ricks S, Doody D, Fitzgibbons D, Porter PL, Schwartz SM. NAT2 Genotypes, Tobacco and

Alcohol Consumption, and Oral Cancer Risk. The American Society for Cancer Research 92nd Annual Meeting. New Orleans, LA. Proc Am Assoc Cancer Res, 42:38, 2001.

28. Schwartz SM, Doody D, Ricks S, Fitzgibbons D, Porter PL, Chen C. NQO1 Genotypes, Alcohol and

Tobacco Consumption, and Oral Cancer Risk. The American Society for Cancer Research 92nd Annual Meeting. New Orleans, LA. Proc Am Assoc Cancer Res, 42:409, 2001.

29. Doherty J, Weiss NS, Dightman D, Houck J, Chen C. Polymorphisms in CYP1A1, CYP1A2, CYP1B1,

and COMT and Risk of Endometrial Cancer. Poster presented at the American Society for Cancer Research 92nd Annual Meeting. New Orleans, LA. Proc Am Assoc Cancer Res, 42:409, 2001.

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30. Rosenblatt KA, Doody DR, Fitzgibbons ED, Daling JR, Chen C, and Schwartz SM. Marijuana use is not associated with the risk of oral squamous cell cancer. The American Society for Cancer Research 92nd Annual Meeting. New Orleans, LA. Proc Am Assoc Cancer Res, 42:887, 2001.

31. Atkinson C, Skor HE, Fitzgibbons ED, Scholes D, Chen C, Wähälä K, Schwartz SM, Lampe JW. Urinary

equol excretion and 2– and 16α– hydroxyestrone concentrations: an observational study of women aged 25–56 years living in Western Washington State. The 4th International Symposium on “The Role of Soy in Preventing and Treating Chronic Disease”. 2001.

32. Cheng C, Méndez E, Chen C and Zhao LP. Regression–based statistical methods to analyze differentially expressed genes and its application to a study of oral cancer transcriptional profiles. The Second Annual Northwest Microarray Conference. Seattle, Washington. August 15–17, 2001.

33. Chen C, Lamharzi N, Weiss NS, Etzioni R, Dightman DA, Barnett M, DiTommaso D, Goodman G.

Polymorphic markers in the SRD5A2 gene and androgen receptor gene and the risk of prostate cancer. The American Society for Cancer Research 93rd Annual Meeting. San Francisco, CA. 2002. Proc Am Assoc Cancer Res, 43:935, 2002.

34. Boffetta P, Lewis S, Benhamou S, Olshan AF, Coutelle C, Diehl S, Hayes R, Schwartz SM, Chen C,

Zavras A, Wei Q, Brennan PJ. Alcohol dehydrogenase type 3 genotype, alcohol consumption and risk of head and neck cancer: a pooled analysis. The American Society for Cancer Research 93rd Annual Meeting. San Francisco, CA. Proc Am Assoc Cancer Res, 43:853, 2002.

35. Schwartz SM, Ricks S, Doody D, Fitzgibbons ED, Porter PL, Chen C. Oral cancer risk in relation to

NAT1 genotypes, cigarette smoking, and alcohol consumption. Poster presented at the American Society for Cancer Research 93rd Annual Meeting. San Francisco, CA. Proc Am Assoc Cancer Res, 43:853, 2002.

36. Doherty JA, Weiss NS, Houck JR, Thornton PJ, Chen C. Polymorphisms in CYP1A1, CYP1A2, and

CYP1B1, and risk of endometrial cancer. Poster presented at the American Society for Cancer Research 93rd Annual Meeting. San Francisco, CA. Proc Am Assoc Cancer Res, 43:774, 2002.

37. Mendez E, Cheng C, Farwell DG, Agoff SN, Futran ND, Zhao LP, Weymuller EA Jr, Maronian NC, Chen

C. Transcriptional expression profiling of oral squamous cell carcinomas. American Head and Neck Society Annual Meeting. Boca Raton, FL. May 11, 2002.

38. Lewis S, Boffetta P, Brennan PJ, Bell D, Benhamou S, Bouchardy C, Caporaso N, Chen C, Coutelle C,

Diehl S, Hayes R, Olshan AF, Schwartz S, Sturgis E, Wei Q, Zavras A. Alcohol dehydrogenase type 3 genotype, alcohol consumption and riskof head and neck cancer: a pooled analysis. Submitted to "Molecular Epidemiology in Preventative Medicine Achievements and New Challenges" Conference. Krakow, Poland. June 2002.

39. Chen C, Ricks S, Doody DRR, Fitzgibbons ED, Porter PL, Schwartz SM. N–acetyltransferase 2

polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk. Alcohol Res, 7 (3):115, 2002.

40. Adams F, Newton KM, Chen C, Emerson SS, Potter JD, Lampe JW. Soy isoflavones do not modulate

insulin–like growth factors in an older population: a randomized controlled. American Institute for Research on Cancer International Research Conference on Food, Nutrition, and Cancer. Washington, D.C. July11–12, 2002.

41. Chen C, Mendez E, Cheng C, Farwell DG, Ricks S, Agoff SN, Futran ND, Weymuller EA Jr, Maronian

NC, Zhao LP. Transcriptional profiles of oral squamous cell carcinomas of the oral cavity. Oral presentation. The Sixth Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancer. McLean, VA. October 9–13, 2002.

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42. Chen C, Weiss NS, Lewis SK, Stanczyk FZ, Etzioni R, DiTommaso DG, Barnett M, Goodman GE.

Prospective study of endogenous sex hormones and prostate cancer risk. Poster presentation at the 94th American Association for Cancer Research Annual Meeting, Washington D.C. Proc Am Assoc Cancer Res, 44:720, 2003.

43. Adams KF, Chen C, Newton KM, Potter JD, Lampe JW. Modulation of prostate–specific antigen (PSA)

by soy isoflavones: A Pilot study. Poster presentation at the 94th American Association for Cancer Research Annual Meeting, Washington D.C. Proc Am Assoc Cancer Res, 44:780, 2003.

44. Doherty JA, Weiss NS, Freeman RJ, Houck JR, Thornton PJ, Chen C. Polymorphisms in ERα and risk

of endometrial cancer. The 94th American Association for Cancer Research Annual Meeting, Washington D.C. Proc Am Assoc Cancer Res, 44:1080, 2003.

45. Marino JL, Holt VL and Chen C. Polymorphisms of glutathione S–transferase MU–1 (GSTM1) and of

catechol–o–methyltransferase (COMT) and risk of endometriosis. The 59th Annual Meeting of the American Society for Reproductive Medicine (2003), October 11–15, 2003.

46. Atkinson C, Lampe J, Skor H, Fitzgibbons ED, Scholes D, Chen C, Wähälä K, Schwartz S. Urinary

excretion of phytoestrogens and risk of uterine fibroids: a population–based case–control study among women aged 26–63 years living in the United States. Experimental Biology Annual Meeting. 2003.

47. Starr JR, Chen C, Hsu L, Ricks S, Weiss NS, Malone KE, Schwartz SM. Case–parent triad study of

maternal insulin–like growth factor I polymorphisms and testicular cancer risk. AACR Special Conference in Cancer Research: “SNPs, Haplotypes, and Cancer: Applications in Molecular Epidemiology”. Sonesta Beach Resort Key Biscayne, Key Biscayne, FL. September 13–17, 2003.

48. Biggs ML, Chen C, Doody DR, Ricks S, Schwartz SM. No association between microsomal epoxide

hydrolase SNPs or haplotypes and risk of oral squamous cell cancer in a population–based study. AACR Special Conference in Cancer Research: “SNPs, Haplotypes, and Cancer: Applications in Molecular Epidemiology”. Sonesta Beach Resort Key Biscayne, Key Biscayne, FL. September 13–17, 2003.

49. Kuo WP, Mendez E, Chen C, Whipple M, Park PJ. Functional Relationships Between Gene Pairs in Oral

Squamous Cell Carcinoma. American Medical Informatics Association Meeting. Washington D.C. November 2003.

50. Babington JR, Ricks S, Schwartz SM and Chen C. Genetic variation in the matrix metaloproteinase 3

gene and risk of oral squamous cell carcinoma. The University of Washington Medical Student Research Training Program (MSRTP) Summer Symposium. 2003.

51. Chen C, Lewis SK, Voigt L, Fitzpatrick A, Plymate SR, Weiss NS. Prospective study of prostate cancer in

relation to serum levels of insulin–like growth factor–I and insulin–like growth factor binding protein–3. Poster presentation at the 95th American Association for Cancer Research Annual Meeting. Orlando, Florida. Proc Am Assoc Cancer Res, 45:863, 2004.

52. Doherty JA, Lewis SK, Ray R, Gao Dao Li, Stalsberg H, Feng Z, Thomas DB, Chen C. Serum IGF–1

and IGFBP–3 and risk of fibrocystic breast conditions among women in the Chinese breast self–examination trial. Poster presentation at the 95th American Association for Cancer Research Annual Meeting. Orlando, Florida. Proc Am Assoc Cancer Res, 45:863, 2004.

53. Babington JR, Schwartz SM, Ricks SM, Kim H, Doody DR, Chen C. Matrix metalloproteinase–3 gene

variation and risk of oral squamous cell carcinoma. Oral presentation by Babington as the recipient of the AACR AstraZeneca Scholar–in–Training Award at the 95th American Association for Cancer Research Annual Meeting. Orlando, Florida. Proc Am Assoc Cancer Res, 45:917, 2004.

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54. Starr JR, Chen C, Hsu L, Ricks S, Weiss NS, Malone KE, Schwartz SM. IGF polymorphisms and

testicular cancer risk: Results from a population–based case–parent triad and case–control study. The 95th American Association for Cancer Research Annual Meeting. Orlando, Florida. Proc Am Assoc Cancer Res, 45:863, 2004.

55. Biggs ML, Chen C, Ricks S, Doody D, Schwartz SM. Polymorphisms in genes encoding oxidative stress

defense enzymes and risk of testicular germ cell carcinoma. The 95th American Association for Cancer Research Annual Meeting. Orlando, Florida. Proc Am Assoc Cancer Res, 45:255, 2004.

56. Whipple ME, Méndez E, Farwell DG, Agoff SN, and Chen, C. A Genomic Predictor of Oral Squamous

Cell Carcinoma Using Principal Component Analysis. Oral presentation, The American Laryngological, Rhinological and Otological Society Western Section Meeting. Scottsdale, AZ. 2004.

57. Mendez E, Fan WH, Agoff SN, Farwell DG, Zhao LP, Whipple M, Futran N, Weymuller EA, Maronian N,

Chen C. Genetic markers for metastatic oral squamous cell carcinomas to cervical lymph nodes. Oral presentation, “Best of Basic Science Series”, 6th International Conference on Head and Neck Cancer. Washington D.C. August 7–11, 2004.

58. Siahpush SH, Vaughan TL, Sanchez C, Chen C, Lewis SK, Odze RD, Rabinovitch PS, Reid BJ. Insulin–

like growth factors and risk of neoplastic progression to esophageal adenocarcinoma in persons with Barrett’s Esophagus. Presented at the 3rd Annual American Association for Cancer Research International Conference on Frontiers in Cancer Research. Seattle, WA. October16–20, 2004.

59. Huang W–Y, Olshan AF, Schwartz SM, Berndt SI, Chen C, Llaca V, Chanock SJ, Fraumeni JF Jr.,

Hayes RB. DNA repair polymorphisms and risk of head and neck cancer: A pooled analysis. Presented at the 3rd Annual American Association for Cancer Research International Conference on Frontiers in Cancer Research. Seattle, WA, USA. October16–20, 2004.

60. Chen C, Blackston C, Xue K, Doherty JA, Ray R, Gao Dao Li, Stalsberg H, Feng Z, Thomas DB. GSTP1

polymorphisms, nutritional factors, and risk of breast cancer and benign fibrocystic breast conditions among women in a breast self–examination trial in Shanghai, China. Presented at the 96th American Association for Cancer Research Annual Meeting. Anaheim, California. Proc Am Assoc Cancer Res, 46:1368, 2005.

61. Doherty JA, Blackston CR, Ray RM, Stalsberg H, Gao DL, Feng Z, Thomas DB, Chen C. Insulin–like

growth factor–I CA–repeat polymorphism and risk of fibrocystic breast conditions among women in a breast self–examination trial in Shanghai, China. Presented at the 96th American Association for Cancer Research Annual Meeting. Anaheim, California. Proc Am Assoc Cancer Res, 46:762–763, 2005.

62. Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Barlow WE, and Chen C. Polymorphic variation in

nucleotide excision repair genes and risk of endometrial cancer. Presented at the 96th American Association for Cancer Research Annual Meeting. Anaheim, California. 2005. Proc Am Assoc Cancer Res, 46:966–967, 2005.

63. Starr JR, Chen C, Doody DR, Hsu L, Ricks S, Weiss NS, Biggs ML, Schwartz SM. Risk of testicular

germ cell cancer in relation to variation in maternal and offspring cytochrome P450 genes involved in catechol estrogen metabolism. Presented at the 96th American Association for Cancer Research Annual Meeting. Anaheim, California. 2005. Proc Am Assoc Cancer Res, 46:304–305, 2005

64. Schwartz, SM, Biggs ML, Ricks S, Starr JR, Weiss NS, Chen C. Androgen Receptor Polyglutamine

Repeat Polymorphisms and Testicular Germ Cell Cancer Risk. Presented at the 96th American Association for Cancer Research Annual Meeting. Anaheim, California. 2005. Proc Am Assoc Cancer Res, 46:764, 2005.

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65. Hashibe M, Benhamou S, Chen C, Franceschi S, Hayes R, Kelsey K, Lazarus P, Luce D, Muscat J, Olshan A, Peters ES, Purdue M, Schwartz S, Smith E, Stücker I, Sturgis E, Wei Q, Zhang Z–F, Brennan P, Boffetta P. International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Presented at the 96th American Association for Cancer Research Annual Meeting. Anaheim, California. 2005. Proc Am Assoc Cancer Res, 46:959, 2005.

66. Choi P and Chen C. Examination of genetic expression profiles of oral cancer in the context of biological

pathways. 10th International Congress on Oral Cancer. Island of Crete, Greece. April 20–24, 2005. 67. Chen C, Doherty JA, Weiss NS. Polymorphisms in CYP 17, CYP19, and endometrial cancer risk. The

2nd NCI Epidemiology Leadership Workshop: Understudied Rare Cancers. Boston, MA. Sept 11–13, 2005.

68. Doherty JA, Haugen K, Siebold B, Voigt LF, Hill D, Beresford SA, Chen C, Weiss NS. Long–term use of postmenopausal estrogen and progestin hormone therapies and risk of endometrial cancer. The 2nd NCI Epidemiology Leadership Workshop: Understudied Rare Cancers. Boston, MA. Sept 11–13, 2005. 69. Schwartz SM, Biggs ML, Starr JR, Barr DB, Needhan LL, Hus L, Weiss NS, Chen C. Adult testicular

cancer, lifestyle and blood specimen study. The 2nd NCI Epidemiology Leadership Workshop: Understudied Rare Cancers. Boston, MA. Sept 11–13, 2005.

70. Marino JL, Haugen KL, Holt VL, Chen C. Risk of endometriosis, disease presentation, disease location,

and polymorphisms of catechol estrogen metabolism genes. The 9th World Congress on Endometriosis. Maastricht, the Netherlands. September 14–17, 2005,

71. Lohavanichbutr P, Houck J, Fan W, Yueh B, Mendez E, Futran N, Farwell DG, Upton MP, Schwartz SM,

Zhao LP, Chen C. Gene expression profiling indicates dysregulation of distinct cellular pathways in HPV positive and HPV negative oral squamous cell carcinomas. Poster presentation at the 97th American Association for Cancer Research Annual Meeting. Washington, D.C. April 1–5, 2006. Proc Am Assoc Cancer Res, 47:195, 2006.

72. Chen C, Doherty JA, Weiss NS. Polymorphisms in CYP17 and CYP19, body mass index, unopposed

estrogen use, and endometrial cancer risk. The 97th American Association for Cancer Research Annual Meeting. Washington, D.C, April 1–5, 2006. Proc Am Assoc Cancer Res, 47:1269, 2006.

73. Doherty JA, Ray R, Blackston CR, Gao DL, Stalsberg H, Feng Z, Thomas DB, Chen C. CYP1A1, CYP1A2, and CYP1B1, and risk of breast cancer and fibrocystic breast conditions among

women in the Chinese breast self–examination trial. The 97th American Association for Cancer Research Annual Meeting. Washington, D.C. Proc Am Assoc Cancer Res, 47:1266–1267, 2006.

74. Marino JL, Chen C, Davis S, Holt VL. Increased risk of endometriosis among health care

workers and flight attendants. The 2nd North American Congress of Epidemiology, Seattle, Washington. June 21–24, 2006. Am J Epidemiol 163 (Suppl): S1–S258 (231–S), 2006.

75. Holt SK, Rossing MA, Malone KE, Chen C, Schwartz SM, Weiss NS. Ovarian cancer risk and polymorphisms involved in estrogen catabolism. The 2nd North American Congress of

Epidemiology. Seattle, Washington. June 21–24, 2006. Am J Epidemiol 163 (Suppl): S1–S258 (L14), 2006.

76. Choi P, Jordan CD, Enriquez L, Mendez E, Houck J, Yueh B, Farwell G, Chen C. Molecular markers of

oral squamous cell carcinogenesis – from gene chips to tissue microarrays. Podium Presentation S027. American Head and Neck Society Annual Meeting & Research Workshop on the Biology, Prevention & Treatment of Head & Neck Cancer. Chicago, Illinois. August 2006.

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77. Houck J, Lohavanichbutr P, Yueh B, Mendez E, Futran N, Upton M, Schwartz SM, Chen C. Promoter methylation status of tumor suppressor and cell adhesion genes in oral squamous cell carcinomas. Podium Presentation S078. American Head and Neck Society Annual Meeting & Research Workshop on the Biology, Prevention & Treatment of Head & Neck Cancer. Chicago, Illinois. August 2006.

78. Saltzman BS, Doherty JA, Hill DA, Beresford SA, Voigt LF, Chen C, Weiss NS. Diabetes and

Endometrial Cancer: An Evaluation of the Modifying Effects of Other Known Risk Factors. American Association for Cancer Research Frontiers in Cancer Prevention Research Meeting. Boston, MA. November 2006.

79. Marron M, Boffett P, Benhamou S, Castellsague X, Chen C, Curado MP, Maso LD, Daudt AW, Fabianova

E, Wünsch–Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf–Neto J, Olshan AF, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia–Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Berthiller J, Brennan P, Hashibe M. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk: pooled analysis in the INHANCE consortium. The second annual ENCIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility) Network Meeting. Maastricht, The Netherlands. February 25–28, 2007.

80. Chen C, Doherty JA, Loomis MM; Fish S, Ray R, Fan W, Zhao LP, Gao DL, Stalsberg H, Feng Z,

Thomas DB. Genetic variation in CYP19 and risk of breast cancer and fibrocystic breast conditions among women in China. The 98th American Association for Cancer Research Annual Meeting. Los Angeles, CA. April 14–18, 2007. Proc Am Assoc Cancer Res, 48: 619–620, 2007.

81. Doherty JA, Loomis MM, Fan W, Zhao LP, Chen C. CYP19 polymorphisms, haplotypes and endometrial

cancer risk. The 98th American Association for Cancer Research Annual Meeting. Los Angeles, CA. April 14–18, 2007. Proc Am Assoc Cancer Res, 48: 620, 2007.

82. Reding KW, Chen C, Li CI, Carlson CS, Wilkerson J, Farin FM, Daling JR, and Malone KE. Genetic

polymorphisms in the estrogen metabolism pathway as modifiers of the effect of hormone therapy in breast cancer risk. The 98th American Association for Cancer Research Annual Meeting. Los Angeles, CA. April 14–18, 2007. Proc Am Assoc Cancer Res, 48: 623, 2007.

83. Marino JL, Chen C, Davis S, Holt VL. Shift work, hCLOCK T3111C polymorphism, and endometriosis

risk. 40th Society for Epidemiologic Research Annual Meeting. Boston, Massachusetts. June 19–22, 2007.

84. Biggs ML, Eaton DL, Weiss NS, Chen C, Barr DB, Needham LL, Schwartz SM. Serum p,p’–DDE,

androgen receptor polymorphisms, and risk of testicular germ cell carcinoma. The 19th Conference of the International Society for Environmental Epidemiology. Mexico City, Mexico. September 5–9, 2007.

85. Boffetta P, Hashiba M, On Behave of INHANCE Consortium. Alcohol drinking in never–tobacco users

and cigarette smoking in never drinkers: pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The 98th American Association for Cancer Research Annual Meeting. Los Angeles, CA. April 14–18, 2007. Proc Am Assoc Cancer Res, 48: 208, 2007.

86. Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody DR, Yueh B, Futran ND, Upton M, Farwell

DG, Schwartz SM, Zhao LP. Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. The 99th American Association for Cancer Research Annual Meeting. San Diego, CA. April 12–16, 2008. Proc Am Assoc Cancer Res, 49: 407, 2008. Abstract nr 1727.

87. Chen Y, Wang P, Xu C, Houck JR, Lohavanichbutr P, Méndez E, Futran ND, Yueh B, Schwartz SM,

Zhao LP, Chen C. Genome–wide Loss of heterozygosity, copy number variations and oral squamous cell carcinoma. The 99th American Association for Cancer Research Annual Meeting. San Diego, CA. April 12–16, 2008. Proc Am Assoc Cancer Res, 49: 43, 2008. Abstract nr 186.

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88. Lohavanichbutr P*, Houck J, Fan W, Yueh B, Méndez E, Futran N, Doody DR, Upton MP, Farwell DG,

Schwartz SM, Zhao LP, Chen C. Genome–wide gene expression profiles of HPV–positive and HPV–negative oropharyngeal cancer: potential implications for treatment choices. The 99th American Association for Cancer Research Annual Meeting. San Diego, CA. April 12–16, 2008. Proc Am Assoc Cancer Res, 49: 400, 2008. Abstract nr 1697.

*Dr. Lohavanichbutr won the 2008–2010 GSK Clinical Scholar Award for this work. 89. Méndez E, Houck J, Doody D, Lohavanichbutr P, Fan W, Yueh B, Futran ND, Upton MP, Farwell DG,

Zhao LP, Schwartz SM, Chen C. A gene expression profile associated with oral cancer Identifies a high risk group of oral cancer patients with poor survival. The 99th American Association for Cancer Research Annual Meeting. San Diego, CA. April 12–16, 2008. Proc Am Assoc Cancer Res, 49: 407, 2008. Abstract nr 1726.

90. Houck J, Lohavanichbutr P, Doody DR, Futran N, Méndez, Yueh B, Upton M, Schwartz SM, Chen C.

Promoter hypermethylation and hypomethylation and oral squamous cell carcinoma. The 7th International Conference on Head & Neck Cancer. San Francisco, CA. July 19–23, 2008.

91. Méndez E, Houck J, Doody DR, Lohavanichbutr P, Yueh B, Futran ND, Upton MP, Schwartz SM, Zhao

L, Chen C. Gene expression profiling identifies a signature associated with oral cancer–specific survival. 7th International Conference on Head & Neck Cancer. San Francisco, CA. July 19–23, 2008.

92. Heck JE, Berthiller J, Vaccarella S, Winn DM, Smith E, Shangina O, Schwartz SM, Purdue M, Eluf–Neto

J, Menezes A, McClean MD, Matos E, Koifman S, Kelsey KT, Herrero R, Hayes RB, Franceschi S, Wünsch–Filho V, Fernandez L, Daudt AW, Curado MP, Chen C, Castellsagué X, Ferro G, Brennan P, Boffetta P, Hashibe M. Sexual behaviors and the risk of Lyon, France. head and neck cancers. Integrated Molecular Epidemiology IARC–EACR–AACR–ECNIS Symposium. July 3–5, 2008.

93. Xu C, Wang P, Liu Y, Upton MP, Lohavanichbutr P, Houck JR, Fan W, Doody DR, Futran ND, Zhao LP,

Schwartz SM, Chen C, Mendez E. Association of genome-wide DNA copy number aberrations and gene expression in metastatic oral squamous cell carcinoma (OSCC). The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009. Proc Am Assoc Cancer Res, 50: 349, 2009. Abstract nr 1458.

94. Marron M, Boffetta P, Benhamou S, Boccia S, Astellsague X, Chen C, Curado MP, Dal Maso L, Daudt

AW, Eluf–Neto J, Fabianova E, Fernandez L, Franceschi S, Hayes RB, Herrero R, Kelsey K, Koifman S, La Vecchia C, Lazarus P, Levi F, Lissowska J, Mates IN, Matos E, McClean M, Menezes A, Muscat J, Olshan AF, Purdue M, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia–Dabrowska N, Talamini R, Wei Q, Winn DM, Wünsch–Filho V, Zaridze D, Zhang Z–F, Ferro G, Chuang S–C, Brennan P, Møller H, Hashibe M. Alcohol drinking and the age specific risk of head and neck cancer among younger, middle age and older populations. The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009. Proc Am Assoc Cancer Res, 50: 517, 2009. Abstract nr 2132.

95. Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn D, Chen C, Letrero R, Harkonarson H, Rader D,

Godwin A, Reilly M, Schwartz SM, Nathanson KL. Variation at KITLG and SPRY4 predispose to testicular germ cell cancer. The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009. Proc Am Assoc Cancer Res, 50: 738, 2009. Abstract nr 3048.

96. Sakoda LC, Doherty JA, Loomis MM, Goodman R, Barnett M, Neuhouser ML, Thornquist MD, Weiss

NS, Goodman GE, Chen C. OGG1 variation and lung cancer risk among participants in the Beta–Carotene and Retinol Efficacy Trial. The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009. Proc Am Assoc Cancer Res, 50: 949, 2009. Abstract nr 3926.

97. Doherty JA, Sakoda LC, Loomis MM, Barnett M, Thornquist MD, Neuhouser ML, Weiss NS, Goodman

GE, Chen C. Genetic variation in MSH5 and lung cancer risk in the Beta–Carotene and Retinol Efficacy

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Trial. The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009. Proc Am Assoc Cancer Res, 50: 950, 2009. Abstract nr 3927.

98. Brennan P, McKay JD, Truong T, Hashibe M, Heath S, Lathrop M, on behalf of the INHANCE

consortium. Genome-wide study of head and neck cancers. The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009.

99. Landi MT, Chatterjee N, Kai Y, Jacobs K, Bergen A, Goldin L, Goldstein AM, Wang Z, Burdette L,

Albanes D, GENEVA study, Oken M, Thun M, Consonni D, Pesatori A, Amos C, Houlston R, Brennan P, Hung R, Gaborieau V, Spitz M, Wang Y, Krokan H, Vatten L, Benhamou S, Metsapalu A, Field JK, Chen C, Goodman G, Bickeboller H, Risch A, Wichmann HE, Rafnar T, Stefansson K, Lathrop M, Bertazzi PA, Tucker MA, Chanock S, Caporaso N. A comprehensive genome-wide association study of lung cancer. The 100th American Association for Cancer Research Annual Meeting. Denver, CO. April 18–22, 2009.

100. Lohavanichbutr P, Houck J, Doody DR, Fan W, Mendez E, Futran N, Upton M, Schwartz SM, Chen C.

Overexpression of miR-21 in oral squamous cell carcinoma and its correlation with TGF-β signaling. America Head and Neck Society Annual Meeting. JW Marriott Desert Ridge Resort, Phoenix, AZ. May 30-31, 2009.

101. Chlebowski RT, Schwartz A, Wakelee H, Anderson GL, Stefanick ML, Manson JE, Chien JW, Chen C,

Wactawski-Wende J, Gass M, Hubblel A. Kotchen JM, Ockene J, Johnson K, O’Sullivan MJ, for the Women's Health Initiative Investigators. Non-Small Cell Lung Cancer (NSCLC) and Estrogen plus Progestin Use in Postmenopausal Women in the Women’s Health Initiative (WHI) Randomized Clinical Trial. 2009 American Society of Clinical Oncology Annual Meeting. Orlando, Florida. May 29-June 2, 2009.

102. Adeney KL, Davis S, Chen C, Emanuel E, Williams MA. Association of Low Birth Weight and Preterm

Birth with Adult Circadian Function. Society of Perinatal Epidemiology Conference, Anaheim, California. June 22-23, 2009.

103. Lohavanichbutr P, Houck J, Stott-Miller M, Doody DR, Mendez E, Futran N, Upton MP, Schwartz SM,

Chen C. MicroRNA as a potential diagnostic marker for oral squamous cell carcinoma. The 101st American Association for Cancer Research Annual Meeting. Washington D.C. April 17–21, 2010.

104. Xu C, Liu Y, Wang P, Fan W, Rue TC, Upton MP, Houck JR, Lohavanichbutr P, Doody DR, Futran ND,

Zhao LP, Schwartz SM, Chen C, Méndez E. Integrative analysis of DNA copy number and gene expression in metastatic tumor cells from oral squamous cell carcinoma for the identification of genes associated with disease-specific survival. The 101st American Association for Cancer Research Annual Meeting. Washington D.C. April 17–21, 2010.

105. Brenner D, Brennan P, Amos C, Chen C, Goodman G, Wichmann E, Bickeboller H, Risch A, Benhamou S,

Hainault P, Hung RJ. Inflammation and Immune Response Pathway Analysis of Lung Cancer Using Hierarchal Modeling Based on GWAS Data. The 101st American Association for Cancer Research Annual Meeting. Washington D.C. April 17–21, 2010.

106. Sakoda LC, Weiss NS, Etzioni R, Barnett M, Goodman GE, Chen C. Relation of androgen receptor

polymorphisms and prostate cancer risk by level of sex steroid hormones. The 101st American Association for Cancer Research Annual Meeting. Washington D.C. April 17–21, 2010.

107. Doherty JA, Weiss NS, Fish S, Loomis MM, Chen C. Polymorphisms in nucleotide excision repair genes

and endometrial cancer risk. The 101st American Association for Cancer Research Annual Meeting. Washington D.C. April 17–21, 2010.

108. Li Q, Chuang S-C, Neto JE, Menezes A, Matos E, Koifman S, Wünsch-Filho V, Fernandez L, Daudt AW,

Curado MP, Winn DM, Franceschi S, Herrero R, Castellsague X, Zhang Z-F, Lazarus P, Muscat J,

Chu Chen Page 51 of 56

McClean M, Kelsey KT, Hayes RB, Purdue MP, Schwartz SM, Chen C, Benhamou S, Olshan AF, Schantz

S, Ferro G, Brennan P, Boffetta P, Hashibe M. Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium. The 101st American Association for Cancer Research Annual Meeting. Washington DC, April 17–21, 2010.

109. Méndez E, Xu C, Liu Y, Fan W, Upton MP, Houck JR, Lohavanichbutr P, Doody DR, Futran ND, Zhao

LP, Schwartz SM, Wang P, Chen C. DNA copy number-associated differential gene expression between tumor cells from metastatic lymph nodes vs. those from node-negative primary tumors in oral cancer. American Head and Neck Society 2010 Annual Meeting. Las Vegas, NV. April 28-29, 2010.

110. Chlebowski RT, Anderson GL, Manson JE, Schwartz AG, Wakelee H, Gass M, Rodabough RJ,

Johnson KC, Wactawski-Wende J, Kotchen JM, Ockene JK, O’Sullivan MJ, Hubbell FA, Chien JW, Chen C, Stefanick ML, For the Women’s Health Initiative. Estrogen alone and lung cancer in postmenopausal women. Society for Gynecologic Oncology 2010 Annual Meeting on Women's Cancer, San Francisco, California. March 14-17, 2010.

111. Lowe KA, Reding K, Carlson CS, Chen CT, Doody DR, Houck J, Daling J, Chen C, Malone KE. The

Influence of Genetic Variants and African Ancestry on Breast Cancer Risk. 2010 Society of Epidemiology Research Annual Meeting. Seattle, Washington. June 23-26, 2010.

112. Chen D, Truong T, Brennan P, McKay JD, on behalf of the INHANCE consortium. A sex specific

association between a 15q25 variant and upper-aero-digestive tract cancers. The 60th Annual meeting of the American Society for Human Genetics, Washington D.C. November 2-6, 2010.

113. Ciosek SL, Kanetsky PA, Mitra N, Vardhanabhuti S, Vaughn DJ, Li M, Letrero R, D'Andrea K, Doody

DR, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Hakonarson H, Reilly MP, Schwartz SM, Nathanson KL. Variation at 9p24.3 (DMRT1) is associated with susceptibility to testicular germ cell tumor. The 60th Annual meeting of the American Society for Human Genetics, Washington, D.C. November 2-6, 2010.

114. Navarro SL, Schwarz Y, Song X, Wang CY, Chen C, Lampe JW. Cruciferous vegetable feeding and

biomarkers of inflammation: Effects of GST genotype in a controlled feeding trial in humans. 2010 Annual Meeting of the American Institute for Cancer Research: Food, Nutrition, Physical Activity and Cancer. Washington, D.C., October 21-22, 2010

115. Lurie G, Gaudet MM, Spurdle AB, Carney ME, Wilkens LR, Yang HP, Weiss NS, Webb PM, Thompson PJ,

Terada K, Setiawan VW, Rebbeck TR, Prescott J, Orlow I, O’Mara T, Olson SH, Narod SA, Matsuno RK, Lissowska J, Levine DA, Le Marchand L, Kolonel LN, Henderson BE, Garcia-Closas M, Doherty JA, De Vivo I, Chen C, Brinton L, Akbari MR, Australian National Endometrial Cancer Study Group and Goodman

MT on behalf of the Epidemiology of Endometrial Cancer Consortium (E2C2). The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. Society of Gynecological Oncology Annual Meeting. 2011.

116. LaPointe J, Upton MP, Doody DR, Houck J, Lohavanichbutr P, Mendez E, Neal Futran, Chen C.

Histologic features of oral squamous cell carcinoma invasive front correlate with genetic markers of survival and/or metastasis. United States &Canadian Academy of Pathology 100th Annual Meeting. San Antonio, TX. February 26-March 4, 2011.

117. Setiawan VW, Karageorgi S, Deming S, Anderson K, Bernstein L, Brinton L, Cai H, Cerhan JR, Chen C,

Cozen W, Doherty JA, Freudenheim J, Goodman M, Horn-Ross P, Lissowska J, Lurie G, Mack T, Matsuno

R, McCann S, Moysich K, Pike MC, Rebbeck TR, Robien K, Shu XO, Spurdle AB, Strom B, The Australian National Endometrial Cancer Study Group, Ursin G, Xiang YB, Webb M, Weiss NS, Wentzensen N, Yang

HP, De Vivo I. Age at last birth and endometrial cancer risk: pooled analysis in the Epidemiology of Endometrial Cancer Consortium. The 102nd American Association for Cancer Research Annual Meeting. Orlando, FL. April 2-6, 2011.

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118. Sharma A, Mendez E, Yueh B, Lohavanichbutr P, Houck J, Doody DR, Futran ND, Upton MP, Schwartz

SM, Chen C. Quality of life in patients with HPV positive oral cavity and oropharyngeal cancer. American Head and Neck Society 2011 Annual Meeting during the Combined Otolaryngology Society Meetings (COSM), April 27-28, 2011, Chicago, IL

119. Sakoda LC, Loomis MM, Doherty JA, Barnett M, Julianto L, Neuhouser ML, Thornquist MD, Weiss NS,

Goodman GE, Chen C. Germline variation in nucleotide excision repair genes and lung cancer risk in smokers. The 102nd American Association for Cancer Research Annual Meeting. Orlando, FL. April 2-6, 2011.

120. Xu C, Liu Y, Wang P, Fan W, Upton MP, Houck JR, Lohavanichbutr P, Doody DR, Futran ND, Zhao LP,

Schwartz SM, Chen C, Méndez E. Integrative Analysis of DNA Copy Number and Gene Expression Identifies G3BP1 and HIRA as Potential Therapeutic Targets against Metastatic Oral Squamous Cell Carcinoma. The 102nd American Association for Cancer Research Annual Meeting. Orlando, FL. April 2-6, 2011.

121. Stott-Miller M, Houck J, Lohavanichbutr P, Schwartz SM, Upton MP, Chen C. Matrix metalloproteinase-1

(MMP1) is an important marker of Oral Squamous Cell Carcinoma. The 102nd American Association for Cancer Research Annual Meeting. Orlando, FL. April 2-6, 2011.

122. Navarro SL, Schwarz Y, Song X, Wang CY, Chen C, Lampe, JW. Response of biomarkers of

inflammation (IL-8,TNF-α, sTNFRI & II) to cruciferous vegetable feeding in a controlled diet study in humans: Effects of GSTM1 and GSTT1 genotypes. The 102nd American Association for Cancer Research Annual Meeting. Orlando, FL, April 2-6, 2011.

123. Phipps AI, Doherty JA, Voigt LF, Hill DA, Beresford SA, Rossing MA, Chen C, Weiss NS. Long-term

use of continuous combined estrogen-progestin hormone therapy and risk of endometrial cancer. American Society of Preventive Oncology Annual Meeting. Las Vegas, NV. March 2011.

124. Sharma A, Mendez E, Yueh B, Lohavanichbutr P, Houck J, Doody DR, Futran N, Upton MP, Schwartz

SM, Chen C. HPV+ oral cancer patients do not have better QOL trajectory. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting; San Francisco, CA. Sept 11-14, 2011.

125. Serrano NA, Xu C, Liu Y, Wang P, Fan W, Houck J, Lohavanichbutr P, Upton MP, Chen C, Méndez E.

The association of DNA copy number and miRNA expression in OSCC. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting; San Francisco, CA. Sept 11-14, 2011.

126. Reding KW, Carlson CS, Chen CT, Doody DR, Ornelas I, Chen C, Lowe K, Weiss L, Simon M, Strom B,

Malone KE. Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among black and white women. Fourth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Washington, DC. September 18-21, 2011.

127. Stott-Miller M, Chen C, Doody DR, Schwartz SM. A history of allergies is associated with reduced risk of

oral squamous cell carcinoma. The 1033d American Association for Cancer Research Annual Meeting. Chicago, IL. March 31-April 4, 2012.

128. Lohavanichbutr P, Houck J, Doody DR, Wang P, Mendez E, Futran N, Upton MP, Schwartz SM, Chen

C. Gene expression in clinically normal oral mucosa of oral cancer patients identifies markers for prediction of disease progression and OSCC-specific survival. The 1033d American Association for Cancer Research Annual Meeting. Chicago, IL. March 31-April 4, 2012.

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129. Setiawan VW, Yang HP, Pike MC, McCann S, Yu H, Xiang Y-B, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PSA, van de Vijver K, Thompson PJ, The Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Shu X, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch H, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska L, Liang X, Lacey JV Jr, Kreiger N, Kolonel LN, Kirsh VA, Henderson BE, Hankinson SE, Goodman MT, Gaudet M, Garcia-Closas M, Friedenrich C, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL. The Association of Body Mass Index with Risk of Endometrial Cancer Subtypes: Pooled Analysis in E2C2. The 1033d American Association for Cancer Research Annual Meeting. Chicago, IL. March 31-April 4, 2012.

130. Uppaluri R, Winkler AE, Law J, Judd NP, Murillo-Sauca O, Sunwoo JB, Houck JR, Lohavanichbutr P,

Mendez E, Schwartz SM, Chen C, Onken MD. Molecular Analysis of Tumor Aggressiveness in a New Mouse Model of Oral Cancer. The 8th International Conference on Head and Neck Cancer, Toronto, Canada, July 21-25, 2012.

131. Margolis KL, Luo J, Tong E, Giovino GA, Lee C, Chen C, Ockene JK, Qi L, Rossouw J. Smoking

cessation, weight gain, and risk of type 2 diabetes mellitus among post-menopausal women. Oral presentation at the 72nd ADA Scientific Sessions. Philadelphia, PA. June 8-12, 2012.

132. Leoncini E, Arzani D, Lee A Y-C, Boffetta P, Hashibe M, Ricciardi W, Boccia S, on behalf of the

INHANCE investigator team (http://inhance.iarc.fr/). Height and risk of head and neck cancer: an individual patient data analysis within the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The 5th Annual European Public Health Association Conference 2012. Malta. Nov 8-10, 2012,

133. Cooper-DeHoff RM, Garvin C, Delaney JA, Winterstein AG, Bavry A, Howard BV, Chen C, Manson J,

Phillips LS, Liu S, Song Y, Shorr RI, Limacher M, and Women’s Health Initiative Investigators. Chronic utilization of medications with metabolic effects and risk for incident diabetes in postmenopausal women. Circulation. 2012;126:A10050. Presented at the American Heart Association 2012 Scientific Sessions, Los Angeles, CA.

134. Prescott J, Setiawan VW, Wentzensen N, Schumacher F, Yu H, Delahanty R, Chanock S, Chen C,

Cook LS, Friedenreich C, Garcia-Closas M, Haiman CA, Hartge P, Horn-Ross P, Le Marchand L, Lissowska J, Lu L, Magliocco, AM, Olson S, Risch HA, Shu X-O, Ursin G, Weiss NS, Yang H, Kraft P, De Vivo I. Body mass index and type 2 diabetes (T2D) genetic risk scores and type I endometrial cancer risk among women of European ancestry. AACR Special Conference: Post-GWAS Horizons in Molecular Epidemiology: Digging Deeper into the Environment. Westin Diplomat Resort and Spa, Hollywood, FL. November 11-14, 2012,

135. Cote ML, Alhajj T, Ruterbusch JJ, Blot WJ, Chen C, Horn-Ross PL, Rebbeck TR, Setiawan VW,

Signorello LB, Simon MS, Weiss NS, Wentzensen N, Yang HP, Olson SH. Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2). The 104th American Association for Cancer Research Annual Meeting. Washington DC, April 6-10, 2013.

136. Wang A, Kubo J, Luo J, Desai M, Henderson M, Chlebowski R, Tindle H, Chen C, Manson JE, Schwartz AG, Cote ML, Wactawski-Wende J, Gomez SL, Patel MI, Stefanick ML, Wakelee HA. Active and passive smoking in relation to lung cancer incidence in the Women’s Health Initiative prospective cohort study. ASCO Annual Meeting. Chicago, IL. May 31- June 4, 2013.

137. Luo J, Margolis KL, Kuller L, Chlebowski R, Wactawski-Wende J, Beresford S, Chen C, Garcia L, Regier

M. Association Between Diabetes, Diabetes Treatment and Endometrial Cancer. Am Diabetes Assoc Annual Meeting, Chicago, IL. June 21-25, 2013.

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138. Vrieze S. on behalf of the Exome Meta-Analysis of Drinking and Smoking (EMADS) consortium. Results from the Exome Meta-Analysis of Drinking and Smoking (EMADS) consortium. Society for Research on Nicotine and Tobacco Annual Meeting, Seattle, WA. February 5-8, 2014.

139. Doherty JA, Houck J, Barnett MJ, Tapsoba JDD, Julianto L, Thornquist MD, Wang C-Y, Chen C,

Goodman GE. Peripheral blood telomere length measured prior to diagnosis and lung cancer survival. The 106th American Association for Cancer Research Annual Meeting. Philladelphia, PA, April 18-22, 2015.

140. Phipps AI, Bhatti P, Neuhouser ML, Chen C, Crane T, Kroenke C, Ochs-Balcom H, Rissling M, Stefanick

M, Treggiari M, Watson NF. Impact of Typical Sleep Duration and Sleep Quality on Cancer Survival. SLEEP 2015 Conference, the 29th Annual Meeting of the Associated Professional Sleep Societies. Seattle, WA. June 6-10.

141. Liu Z, Liu D, Chou Y-L, Faul J, Gong J, Hsu C, Loukola A, Mangino M, Polderman T, Rhode R, Shao Y,

Stringham H, Turcot V, Zhao W, Vrieze S, on behalf of CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour and the GWAS & Sequencing Consortium of Alcohol and Nicotine Use. Findings from the Initial Phase of the GSCAN Exome Chip Project. American Society of Human Genetics Annual Meeting. OctBaltimore, MD. ober 6-10, 2015.

142. Oh H, Anderson GL, Behan S, Brinton LA, Chen C, LeBlanc ES, Manson JE, Pfeiffer R, Wactawski-

Wende J, Wentzensen N, Zaslavsky O, Trabert B. Anthropometric measures and serum estrogen metabolism in postmenopausal women. Epidemiology Congress of the Americas 2016. Miami, Florida. June 21-24, 2016.

143. Linda K, Smith GD, Liu G, Landi MT, Christiani DC, Caporaso NE, McKay JD, Wu X, Aldrich MC, Rennert G, Teare D, Chen C, Goodman GE, Doherty JA, Field JK, Kiemeney LA, Tardón A, Haugen A, Lam S, Le Marchand L, Schabath MB, Andrew AS, Johansson M, Manjer J, Lazarus P, Arnold S, Fehringer G, Zong X, Brennan P, Bojesen SE, Amos CI, Hung RJ. Telomere length and lung cancer risk: developing new instrumental variables for improving causal inference using Mendelian Randomization. The 107th American Association for Cancer Research Annual Meeting. New Orleans, LA. April 16-20, 2016.

144. Brockton NT, Lohavanichbutr P, Enwere E, Upton MP, Kornaga E, Nakoneshny S, Bose P, Chen C, Dort

JC. Expression of tumoral carbonic anhydrase IX and Ki67 in relation to survival in oral cavity squamous cell carcinoma patients. American Head and Neck Society 9th International Conference on Head and Neck Cancer: Technology transforming head and neck cancer care. Seattle, WA. July 16-20, 2016.

145. Hung RJ, McKay JD, Li Y, Han Y, Zong X, Xiao X, Landi MT, Caporaso NE, Christiani DC, Wu X, Le

Marchand L, Field JK, Bickeböller H, Johansson M, TRICL, ILCCO and LC3 Investigators, Brennan P, Amos CI. Lung cancer OncoArray project identified new lung cancer susceptibility loci. IARC 50th Anniversary Conference. Global Cancer: Occurance, Causes, and Avenues to Prevention. Lyon, France. June 8-10, 2016.

146. Jung SY, Barrington W, Lane D, Chen C, Crandall C. Bioavailable Insulin-Like Growth Factor-I as

Mediator of Racial Disparity in Obesity-Relevant Breast and Colorectal Cancer Risk among Postmenopausal Women. American Society of Preventive Oncology (ASPO) 40th Annual Meeting. Columbus, OH. March 13-15, 2016

INVITED PRESENTATIONS Differential Genetic Expression Profiles of Oral Squamous Cell Carcinoma, Fred Hutchinson Cancer Research Center Chinese Scientists Association. March 2002.

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Genetic, Genomics and Squamous Cell Carcinoma of the Oral Cavity. University of Washington Department of Otolaryngology Head and Neck Surgery Grand Round. October 2001. Gene Expression Profiling of Oral Squamous Cell Carcinoma. Fred Hutchinson Cancer Research Center Genetic Epidemiology and Microarray Technology Affinity Group. August 2001. Genetic and Genomic Predictors of Oral Cancer. Graduate Institute of Occupational Safety & Health, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China. December 2003. Serum Markers, Genetic Polymorphisms, and the Etiology of Prostate and Endometrial Cancers. Kaohsiung Medical University Medical Center. Kaohsiung, Taiwan, Republic of China. December 2003. Selection of TagSNPs in Candidate Genes with LDSelect. Second International Head and Neck Cancer Epidemiology (INHANCE) Consortium Meeting, Seattle, WA. February 11, 2004. Genetic Expression Profiles of Oral Squamous Cell Carcinomas: From Molecular Mechanisms to Clinical Outcomes. Oral Biology 575 & Bioengineering 599B Cross–Disciplinary Dental Science Seminar Series. Department of Oral Biology, School of Dentistry, University of Washington, Seattle, WA. January 9, 2006. Oral Cancer: In Search of Prognostic Markers Through Examination of Gene Expression, HPV Infection and Promoter Methylation. China Medical University, Taichung, Taiwan, Republic of China. November 14, 2006. Oral Cancer: In Search of Prognostic Markers Through Examination of Gene Expression, HPV Infection and Promoter Methylation. National Health Research Institutes, Zhunan, Taiwan, Republic of China. November 14, 2006. Oral Squamous Cell Carcinoma: In Search of Early Detection and Prognostic Markers. National Taiwan University Medical Center, Taipei, Taiwan, Republic of China. November 15, 2006. Oral Squamous Cell Carcinoma: In Search of Early Detection and Prognostic Markers. Academia Sinica, Taipei, Taiwan, Republic of China. November 17, 2006. Genetic Polymorphisms in Steroid Hormone Metabolism and Risk of Breast Cancer and Fibrocystic Breast Conditions in Chinese Women. Shanghai Medical Association, Changninh District, Shanghai, People Republic of China. March 15, 2007. Evolving epidemiologic approaches to the study of genetic susceptibility to endometrial cancer. The 21st Annual Meeting on Therapeutic Options for Menopausal Health. Pasadena, California. July 15–17, 2007. Biomarkers for the Prediction of Clinical Outcomes of Oral Squamous Cell Carcinoma. Department of Epidemology and Biosttistics, School of Public Health, Peking University, People Republic of China. April 20, 2011. Biomarkers for the Prediction of Clinical Outcomes of Oral Squamous Cell Carcinoma. School of Stomatology, Peking University, People Republic of China. April 20, 2011. Discoveries of Biomarkers for the Prediction of Clinical Outcomes of Oral Squamous Cell Carcinoma. Chang-Gung University, Taiwan, Republic of China. June 8, 2011. Can Genomic Signatures Guide the Clinical Management of Oral Cancer? Chang-Gung Memorial Hospital. Taiwan, Republic of China. June 10, 2011. Gene Expression Profiles Predictive of Clinical Outcomes of Oral Cancer. University of Hawaii Cancer Center Distinguished Lecture Seminar Series. December 6, 2012.

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Gene Expression Profiles as Predictors of Oral Cancer Survival. Huntsman Cancer Institute Seminar Series, Huntsman Cancer Institute, University of Utah. April 3, 2013. From Identification of Gene Expression Profiles Predictive of Clinical Outcomes of Oral Cancer to Search for Potential Treatment Targets. Summit of Quality Research and Drug Discovery in Chinese Medicine, Macau University of Science and Technology. April 16-17, 2013. Macau, China. Tissue-based Study of Prognostic Gene Expression Profiles. 10th Annual International Head and Neck Cancer Epidemiology Consortium Meeting. May 8, 2013. NY, NY. Polymorphic variation in drug metabolism gene TDP1 in relation to survival among cigarette smokers with small cell lung cancer. International Lung Cancer Consortium (ILCCO) Meeting. May 9, 2013. Mt. Sinai School of Medicine, NY, NY. Survival gene signature in HPV-negative oral cavity cancer. 12th Annual International Head and Neck Cancer Consortium meeting. May 29, 2015. Mount Sinai New York Eye and Ear Infirmary. NY, NY. Validation results of TDP1 polymorphisms and small cell lung cancer survival among ILCCO participating studies. International Lung Cancer Consortium (ILCCO) Meeting. June 7, 2016. International Agency of Research on Cancer (IARC), Lyon, France. CERTIFICATIONS National Registry of Certified Chemists American Board of Clinical Chemistry PROFESSIONAL ORGANIZATIONS American Association for Clinical Chemistry American Association for Cancer Research American Head and Neck Society Academy of Clinical Laboratory Physicians and Scientists International Head and Neck Cancer Epidemiology Consortium (INHANCE) International Epidemiology of Endometrial Cancer Consortium (E2C2, Member of Steering Committee and

Foundaing Member) International Lung Cancer Consortium (ILCCO, Member of Steering Committee 2016-2019) International Cancer of the Head and Neck, Genetics and Environment Study (InterCHANGE, Member of

Steering Committee) PATENTS SUBMISSIONS International Application NO. PCT/US2009/051743. Gene expression profiling identifies Genes Predictive of Oral Squamous Cell Carcinoma and Its Prognosis. Filing Date: July 24, 2009. U.S. Provisional Application No. 61/484,059. Saliva Test for Oral Squamous Cell Carcinoma using Matrix Metalloproteinases 1 and 3. Filing Date: May 9, 2011.