2001 antibiotics

antibioticsU 1200

22 - 165Polyether Antibiotic CP44,161. — The crystal structure of titlecompound (I) monohydrate is elucidated by X-ray analysis and the relativeconfiguration is determined based on the absolute stereochemistry of relatedcompound salinomycin. The polyether molecule adopts a cyclic conformation,stabilized by a centrally located water molecule through hydrogen-bondinginteractions. Further investigations will find out if the water molecule canbe replaced by a metal ion, so that polyether (I) can act as ionophore. —(ALLEN, PAUL; BRIMBLE, MARGARET A.; TURNER, PETER; ActaCrystallogr., Sect. C: Cryst. Struct. Commun. 57 (2001) 1, 95-96; Sch. Chem.,Univ. Sydney, Camperdown, N. S. W. 2006, Australia; EN)

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