1999 terpenes

terpenesU 0200

17 - 183Novel Cytokine Release Inhibitors. Part 3. Truncated Analogues ofTripterine. — Various truncated analogues of tripterine such as (XII),(XIII) and (XIV) are synthesized using the tricyclic and the tetracyclic interme-diates (IX) and (VIII), resp., as the key substrates. It is clearly demonstratedthat the small synthetic compounds have good cytokine release inhibitoryeffects, although less potent than tripterine. Moreover, it is established that theprimary pharmacophore resides on the A/B rings. — (HE, WEI; HUANG,FU-CHIH; GAVAI, ASHVIN; CHAN, WAN K.; AMATO, GEORGE; YU,KIN-TAK; ZILBERSTEIN, ASHER; Bioorg. Med. Chem. Lett. 8 (1998) 24,3659-3664; Dep. Med. Chem., Rhone-Poulenc Rorer Cent. Res., Collegeville,PA 19426, USA; EN)

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